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5 results on '"Cao, Dehan"'

1. Reversible Amine-to-Imine Chemistry at a Covalent Organic Framework for Sustainable Uranium Redox Separation

Author

Wu, Yutian, primary, Li, Pengju, additional, Chen, Long, additional, Li, Ao, additional, Li, Chunyang, additional, Chen, Junchang, additional, Zhai, Fuwan, additional, Xu, Dongyang, additional, Song, Yiting, additional, Cao, Dehan, additional, Sun, Jiazhe, additional, Hu, Ke, additional, Wang, Shuao, additional, and Sheridan, Matthew V., additional

Published
2024
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2. Efficient removal of uranium from the kidneys by a picolinate-based pentadentate chelator.

Author

Cao, Dehan, Chen, Bin, Xu, Yigong, Li, Zongyi, Sun, Tingfeng, Hong, Sheng, Zhu, Tianen, Chen, Lei, Li, Ximeng, Wang, Longxiang, Liu, Jiakai, Jin, Yaqi, Wang, Shuao, and Diwu, Juan

Subjects
*KIDNEYS, *URANIUM, *GEOMETRY, *LIGAND binding (Biochemistry)
Abstract

In conjunction with theoretical calculations, the in vitro and in vivo uranyl binding capabilities of a bidentate picolinate (Pic) ligand and its pentadentate derivative (H2dpa) are investigated. The planar N3O2-donor configuration of H2dpa matches the typical pentagonal-bipyramid coordination geometry of uranyl, demonstrating a remarkable removal preference for uranyl in the kidneys. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Self‐Aggregated Nanoscale Metal–Organic Framework for Targeted Pulmonary Decorporation of Uranium

Author

Chen, Lei, primary, Wang, Xiaomei, additional, Chen, Mengping, additional, Sun, Qiwen, additional, Chen, Yemeng, additional, Zhang, Xiaojie, additional, Hong, Rui, additional, Xu, Yigong, additional, Guan, Jingwen, additional, Hong, Sheng, additional, Cao, Dehan, additional, Sun, Tingfeng, additional, Li, Ximeng, additional, Chen, Lanhua, additional, and Diwu, Juan, additional

Published
2023
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5. In VivoUranium Decorporation by a Tailor-Made Hexadentate Ligand

Author

Chen, Bin, Hong, Sheng, Dai, Xing, Li, Ximeng, Huang, Qi, Sun, Tingfeng, Cao, Dehan, Zhang, Hailong, Chai, Zhifang, Diwu, Juan, and Wang, Shuao

Abstract

The sequestration of uranium, particularly from the deposited bones, has been an incomplete task in chelation therapy for actinide decorporation. Part of the reason is that all previous decorporation ligands are not delicately designed to meet the coordination requirement of uranyl cations. Herein, guided by DFT calculation, we elaborately design a hexadentate ligand (TAM-2LI-MAM2), whose preorganized planar oxo-donor configuration perfectly matches the typical coordination geometry of the uranyl cation. This leads to an ultrahigh binding affinity to uranyl supported by an in vitrodesorption experiment of uranyl phosphate. Administration of this ligand by prompt intraperitoneal injection demonstrates its uranyl removal efficiencies from the kidneys and bones are up to 95.4% and 81.2%, respectively, which notably exceeds all the tested chelating agents as well as the clinical drug ZnNa3-DTPA, setting a new record in uranyl decorporation efficacy.

Published
2022
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