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La presente investigación tuvo como objetivo general determinar la influencia de las empresas de alto desempeño en la tipología de los negocios de restauración comercial en ate-vitarte, 2021; de enfoque cuantitativo, diseño no experimental, de nivel explicativo; con una población de 104 gerentes de restaurantes del distrito de Ate, siendo la muestra 82. Se hizo uso de dimensiones como grupos de interés, procesos, recursos, organización, tipo familiar, tipo monoproducto y neorestauración. Respecto al dato de las variables se adaptó la escala de Liker que consta de 14 indicadores y 20 items respectivamente. El resultado que se obtuvo fue que las empresas de alto rendimiento tienen influencia significativa en la tipología de los negocios de restauración comercial donde el 19% de los gerentes manifestaron. Las empresas de alto rendimiento son de nivel alto, asimismo un 40,5% con un nivel medio y finalmente un 40,5% con un nivel bajo mientras que la tipología de los negocios de restauración comercial es de nivel alto, asimismo un 40,5% con un nivel medio y finalmente un 40,5% con un nivel bajo, el análisis estadístico permitió corroborar que las empresas de alto rendimiento tienen una incidencia probabilística y estadísticamente significativa (p-valor

La presente investigación tiene como objetivo conocer las perspectivas de los estudiantes de nivel superior sobre la modalidad virtual en el proceso enseñanza-aprendizaje, que llevaron a cabo por la pandemia. El trabajo se desarrolló bajo el enfoque cualitativo, utilizando como técnica la entrevista, donde arrojó que los alumnos no contaban con un servicio de internet de calidad, por lo que afectó su aprendizaje, también estudiantes que no terminaron el semestre por falta de dinero para comprar equipo tecnológico. Se concluye que los estudiantes no estaban lo suficientemente preparados para aprender de esta manera, y gracias a esta modalidad educativa fue que desarrollaron competencias tecnológicas, y a pesar de todas las circunstancias que pasaron, se adaptaron a este cambio.

El presente estudio tuvo como objetivo determinar la correlación entre las variables aprendizaje cooperativo y sus dimensiones, y las habilidades geométricas en estudiantes del nivel primaria educativas, UGEL Nº 01-Villa María del Triunfo, UGEL Nº 01 – 2018. La investigación es de tipo básica, presenta un diseño no experimental, correlacional y transversal, y de enfoque cuantitativo. La metodología fue hipotético deductiva, la población estuvo constituida por 210 estudiantes del tercer grado del nivel primaria, a los cuales se les aplicó como instrumento, para medir el aprendizaje cooperativo, un cuestionario, y para medir las habilidades geométricas, una prueba validada por juicio de experto, sobre una muestra de 106 estudiantes. Para determinar la confiabilidad se tomó una prueba piloto a 20 estudiantes, obteniéndose un coeficiente de confiabilidad de Alfa Cronbach de 0.78 y 0.94, y para la contrastación de las hipótesis se utilizó la prueba no paramétrica Rho de Spearman. Los resultados obtenidos muestran que existe una relación positiva y estadísticamente significativa (rs = 0.875; p =0.001 < 0.05) entre las variables aprendizaje cooperativo y las habilidades geométricas en los estudiantes de primaria de la Institución Educativa UGEL Nº 01 Villa maría del Triunfo, lo que confirma la hipótesis planteada.

The COVID-19 pandemic has caused a profound change in health organizations at both the primary and hospital care levels. This cross-sectional study aims to investigate the impact of the COVID-19 pandemic in the annual rate of new cancer diagnosis in two university-affiliated hospitals. This study includes all the patients with a pathological diagnosis of cancer attended in two hospitals in Málaga (Spain) during the first year of pandemic. This study population was compared with the patients diagnosed during the previous year 2019. To analyze whether the possible differences in the annual rate of diagnoses were due to the pandemic or to other causes, the patients diagnosed during 2018 and 2017 were also compared. There were 2340 new cancer diagnosis compared to 2825 patients in 2019 which represented a decrease of −17.2% (p = 0.0001). Differences in the number of cancer patients diagnosed between 2018 and 2019 (2840 new cases, 0.5% increase) or 2017 and 2019 (2909 new cases, 3% increase) were not statistically significant. The highest number of patients lost from diagnosis in 2020 was in breast cancer (−26.1%), colorectal neoplasms (−16.9%), and head and neck tumors (−19.8%). The study of incidence rates throughout the first year of the COVID-19 pandemic shows that the diagnosis of new cancer patients has been significantly impaired. Health systems must take the necessary measures to restore pre-pandemic diagnostic procedures and to recover lost patients who have not been diagnosed.

15 Background: Accurate genotyping is mandatory for the management of mCRC pts. Tissue-based testing is still the SoC; however, is not available for all pts. and may be exhausted by serial testing, resulting in incomplete genotyping. We aimed to establish the validity of comprehensive non-invasive ctDNA testing in 1L mCRC pts for whom SoC tissue genotyping was available. Methods: 1L mCRC pts were tested with a comprehensive ctDNA test (Guardant360), a RAS ctDNA test (OncoBeam), and SoC tissue testing at the time of diagnosis. The primary endpoint was NCCN guideline biomarker discovery rate ( KRAS, NRAS, and BRAF mutations, ERBB2 amplification, and microsatellite instability). Results: In 91 evaluable pts, the biomarker discovery rate was 54.9% (50/91) for SoC tissue testing, 59.3% (54/91) for comprehensive ctDNA testing ( p= 0.0318 for non-inferiority vs. SoC), and 42.9% (39/91) for RAS ctDNA testing (inferiority not rejected vs. SoC). Both comprehensive and RAS ctDNA testing showed high positive agreement (85%, 44/52, and 86%, 31/36) and negative agreement (96%, 268/279, and 93%, 93/100) relative to SoC tissue testing at the gene level. Expanding genotyping beyond KRAS codon 12/13 mutations increased biomarker discovery rate by 56% for tissue testing (50/91 vs. 32/91, McNemar’s p< 0.0001) and by 64% for comprehensive ctDNA (54/91 vs. 33/91, McNemar’s p< 0.0001). Turnaround time was significantly shorter for comprehensive ctDNA testing vs. SoC tissue testing (mean 11.7 days vs. 23.0 days, paired T-test p= 0.0002). On retrospective analysis, 92% of biomarker-positive pts would have been identified at 2 weeks using the comprehensive ctDNA test for initial genotyping with reflex to tissue for biomarker-negative pts, whereas initial use of SoC tissue testing would have identified only 85% of positive pts at 4 weeks (Fisher’s exact p< 0.0001). Conclusions: As previously reported for lung cancer, comprehensive ctDNA testing in 1L mCRC identifies at least as many biomarker-positive pts as SoC tissue genotyping with high concordance to tissue and in half the turnaround time.

Background. 5-HT3-receptor antagonists are one of the mainstays of antiemetic treatment, and they are administered either i.v. or orally. Nevertheless, sometimes neither administration route is feasible, such as in patients unable to admit oral intake managed in an outpatient setting. Our objective was to evaluate the bioavailability of s.c. granisetron. Patients and Methods. Patients receiving platinum-based chemotherapy were randomized to receive 3 mg of granisetron either s.c. or i.v. in a crossover manner during two cycles. Blood and urine samples were collected after each cycle. Pharmacokinetic parameters observed with each administration route were compared by analysis of variance. Results. From May to November 2005, 31 patients were included and 25 were evaluable. Subcutaneous granisetron resulted in a 27% higher area under the concentration–time curve for 0–12 hours (AUC0–12h) and higher levels at 12 hours, with similar values for AUC0–24h. The maximum concentration was lower with the s.c. than with the i.v. route and was observed 30 minutes following s.c. administration. Conclusion. Granisetron administered s.c. achieves complete bioavailability. This is the first study that shows that s.c. granisetron might be a valid alternative to i.v. delivery. Further trials to confirm clinical equivalence are warranted. This new route of administration might be especially relevant for outpatient management of emesis in cancer patients.