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5. Pulmonary Congestion During Exercise Stress Echocardiography in Ischemic and Heart Failure Patients

Author

Merli, Elisa, Ciampi, Quirino, Scali, Maria Chiara, Zagatina, Angela, Merlo, Pablo Martin, Arbucci, Rosina, Daros, Clarissa Borguezan, de Castro e Silva Pretto, José Luis, Amor, Miguel, Salamè, Michael F., Mosto, Hugo, Morrone, Doralisa, D’Andrea, Antonello, Reisenhofer, Barbara, Rodriguez-Zanella, Hugo, Wierzbowska-Drabik, Karina, Kasprzak, Jaroslaw D., Agoston, Gergely, Varga, Albert, Lowenstein, Jorge, Dodi, Claudio, Cortigiani, Lauro, Simova, Iana, Samardjieva, Martina, Citro, Rodolfo, Celutkiene, Jelena, Re, Federica, Monte, Ines, Gligorova, Suzana, Antonini-Canterin, Francesco, Pepi, Mauro, Carpeggiani, Clara, Pellikka, Patricia A., and Picano, Eugenio

Published
2022
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6. Functional, Anatomical, and Prognostic Correlates of Coronary Flow Velocity Reserve During Stress Echocardiography

Author

Ciampi, Quirino, Zagatina, Angela, Cortigiani, Lauro, Gaibazzi, Nicola, Borguezan Daros, Clarissa, Zhuravskaya, Nadezhda, Wierzbowska-Drabik, Karina, Kasprzak, Jaroslaw D., de Castro e Silva Pretto, José Luis, D'Andrea, Antonello, Djordjevic-Dikic, Ana, Monte, Ines, Simova, Iana, Boshchenko, Alla, Citro, Rodolfo, Amor, Miguel, Merlo, Pablo Martin, Dodi, Claudio, Rigo, Fausto, Gligorova, Suzana, Dekleva, Milica, Severino, Sergio, Lattanzi, Fabio, Scali, Maria Chiara, Vrublevsky, Alexander, Torres, Marco A.R., Salustri, Alessandro, Rodrìguez-Zanella, Hugo, Costantino, Fabio Marco, Varga, Albert, Bossone, Eduardo, Colonna, Paolo, De Nes, Michele, Paterni, Marco, Carpeggiani, Clara, Lowenstein, Jorge, Gregori, Dario, and Picano, Eugenio

Published
2019
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9. Quality control of regional wall motion analysis in stress Echo 2020

Author

Ciampi, Quirino, Picano, Eugenio, Paterni, Marco, Daros, Clarissa Borguezan, Simova, Iana, de Castro e Silva Pretto, José Luis, Scali, Maria Chiara, Gaibazzi, Nicola, Severino, Sergio, Djordjevic-Dikic, Ana, Kasprzak, Jaroslaw D., Zagatina, Angela, Varga, Albert, Lowenstein, Jorge, Merlo, Pablo Martin, Amor, Miguel, Celutkiene, Jelena, Perez, Julio E., Di Salvo, Giovanni, Galderisi, Maurizio, Mori, Fabio, Costantino, Marco Fabio, Massa, Laura, Dekleva, Milica, Chaves, Daniel Quesada, Trambaiolo, Paolo, Citro, Rodolfo, Colonna, Paolo, Rigo, Fausto, Torres, Marco A.R., Monte, Ines, Stankovic, Ivan, Neskovic, Aleksander, Cortigiani, Lauro, Re, Federica, Dodi, Claudio, D'Andrea, Antonello, Villari, Bruno, Arystan, Ayana, De Nes, Michele, and Carpeggiani, Clara

Published
2017
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10. B-lines with Lung Ultrasound: The Optimal Scan Technique at Rest and During Stress

Author

Picano, Eugenio, Ciampi, Quirino, Citro, Rodolfo, D'Andrea, Antonello, Scali, Maria Chiara, Cortigiani, Lauro, Olivotto, Iacopo, Mori, Fabio, Galderisi, Maurizio, Costantino, Marco Fabio, Pratali, Lorenza, di Salvo, Giovanni, Bossone, Eduardo, Ferrara, Francesco, Kasprszak, Jaroslaw D., Rigo, Fausto, Gaibazzi, Nicola, Limongelli, Giuseppe, Pacileo, Giuseppe, Severino, Sergio, Pinamonti, Bruno, Massa, Laura, Torres, Marco A.R., Miglioranza, Marcelo H., Daros, Clarissa Borguezan, Luis de Castro e Silva Pretto, José, Djordjevic-Dikic, Ana, Dekleva, Milica, Varga, Albert, Agoston, Gergely, Palinkas, Attila, Zagatina, Angela, Simova, Iana, Amor, Miguel, Lowenstein, Jorge, Merlo, Pablo, Celutkiene, Jelena, Perez, Julio E., Trambaiolo, Paolo, Gregori, Dario, Colonna, Paolo, Andreassi, Maria Grazia, De Nes, Michele, Arystan, Ayana, Paterni, Marco, Carpeggiani, Clara, Zhuravskaya, Nadezhda, and Marzilli, Mario

Published
2017
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15. A New Integrated Clinical-Biohumoral Model to Predict Functionally Significant Coronary Artery Disease in Patients With Chronic Chest Pain

Author

Caselli, Chiara, Rovai, Daniele, Lorenzoni, Valentina, Carpeggiani, Clara, Teresinska, Anna, Aguade, Santiago, Todiere, Giancarlo, Gimelli, Alessia, Schroeder, Stephen, Casolo, Giancarlo, Poddighe, Rosa, Pugliese, Francesca, Le Guludec, Dominique, Valente, Serafina, Sambuceti, Gianmario, Perrone-Filardi, Pasquale, Del Ry, Silvia, Marinelli, Martina, Nekolla, Stephan, Pietila, Mikko, Lombardi, Massimo, Sicari, Rosa, Scholte, Arthur, Zamorano, José, Kaufmann, Philipp A., Underwood, S. Richard, Knuuti, Juhani, Giannessi, Daniela, and Neglia, Danilo

Published
2015
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22. Impact of Selection Bias on Estimation of Subsequent Event Risk

Author

Hu, Yi-Juan, Schmidt, Amand F., Dudbridge, Frank, Holmes, Michael V., Brophy, James M., Tragante, Vinicius, Li, Ziyi, Liao, Peizhou, Quyyumi, Arshed A., McCubrey, Raymond O., Horne, Benjamin D., Hingorani, Aroon D., Asselbergs, Folkert W., Patel, Riyaz S., Long, Qi, Åkerblom, Axel, Algra, Ale, Allayee, Hooman, Almgren, Peter, Anderson, Jeffrey L., Andreassi, Maria G., Anselmi, Chiara V., Ardissino, Diego, Arsenault, Benoit J., Ballantyne, Christie M., Baranova, Ekaterina V., Behloui, Hassan, Bergmeijer, Thomas O., Bezzina, Connie R., Bjornsson, Eythor, Body, Simon C., Boeckx, Bram, Boersma, Eric (H.), Boerwinkle, Eric, Bogaty, Peter, Braund, Peter S., Breitling, Lutz P., Brenner, Hermann, Briguori, Carlo, Brugts, Jasper J., Burkhardt, Ralph, Cameron, Vicky A., Carlquist, John F., Carpeggiani, Clara, Carruthers, Kathryn F., Casu, Gavino, Condorelli, Gianluigi, Cresci, Sharon, Danchin, Nicolas, de Faire, Ulf, Deanfield, John, Delgado, Graciela, Deloukas, Panos, Direk, Kenan, Doughty, Robert N., Drexel, Heinz, Duarte, Nubia E., Dubé, Marie-Pierre, Dufresne, Line, Engert, James C., Eriksson, Niclas, Fitzpatrick, Natalie, Foco, Luisa, Ford, Ian, Fox, Keith A.A., Gigante, Bruna, Gijsberts, Crystel M., Girelli, Domenico, Gong, Yan, Gudbjartsson, Daniel F., Hagström, Emil, Hartiala, Jaana, Hazen, Stanley L., Held, Claes, Helgadottir, Anna, Hemingway, Harry, Heydarpour, Mahyar, Hoefer, Imo E., Hovingh, Kees, Hubacek, Jaroslav A., James, Stefan, Johnson, Julie A., Wouter Jukema, J., Kaczor, Marcin P., Kaminski, Karol A., Kettner, Jiri, Kiliszek, Marek, Kleber, Marcus, Klungel, Olaf H., Kofink, Daniel, Kohonen, Mika, Kotti, Salma, Kuukasjärvi, Pekka, Lagerqvist, Bo, Lambrechts, Diether, Lang, Chim C., Laurikka, Jari O., Leander, Karin, Lee, Vei-Vei, Lehtimäki, Terho, Leiherer, Andreas, Lenzini, Petra A., Levin, Daniel, Lindholm, Daniel, Lokki, Marja-Liisa, Lotufo, Paulo A., Lyytikäinen, Leo-Pekka, Khan Mahmoodi, B., Maitland-van der Zee, Anke H., Martinelli, Nicola, März, Winfried, Marziliano, Nicola, McPherson, Ruth, Melander, Olle, Mons, Ute, Muehlschlegel, Jochen D., Muhlestein, Joseph B., Nelson, Cristopher P., Newton Cheh, Chris, Olivieri, Oliviero, Opolski, Grzegorz, Palmer, Colin N., Pare, Guillaume, Pasterkamp, Gerard, Pepine, Carl J., Pepinski, Witold, Pereira, Alexandre C., Pilbrow, Anna P., Pilote, Louise, Pitha, Jan, Ploski, Rafal, Mark Richards, A., Saely, Christoph H., Samani, Nilesh J., Samman-Tahhan, Ayman, Sanak, Marek, Sandesara, Pratik B., Sattar, Naveed, Scholz, Markus, Siegbahn, Agneta, Simon, Tabassome, Sinisalo, Juha, Gustav Smith, J., Spertus, John A., Stefansson, Kari, Stewart, Alexandre F.R., Stott, David J., Szczeklik, Wojciech, Szpakowicz, Anna, Tanck, Michael W.T., Tang, Wilson H., Tardif, Jean-Claude, ten Berg, Jur M., Teren, Andrej, Thanassoulis, George, Thiery, Joachim, Thorgeirsson, Gudmundur, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Timmis, Adam, Trompet, Stella, van de Werf, Frans, van der Graaf, Yolanda, van der Haarst, Pim, van der Laan, Sander W., Vilmundarson, Ragnar O., Virani, Salim S., Visseren, Frank L.J., Vlachopoulou, Efthymia, Wallentin, Lars, Waltenberger, Johannes, Wauters, Els, and Wilde, Arthur A.M.

Published
2017
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28. Prognostic value of stress echocardiography assessed by the ABCDE protocol

Author

Ciampi, Quirino, primary, Zagatina, Angela, additional, Cortigiani, Lauro, additional, Wierzbowska-Drabik, Karina, additional, Kasprzak, Jaroslaw D, additional, Haberka, Maciej, additional, Djordjevic-Dikic, Ana, additional, Beleslin, Branko, additional, Boshchenko, Alla, additional, Ryabova, Tamara, additional, Gaibazzi, Nicola, additional, Rigo, Fausto, additional, Dodi, Claudio, additional, Simova, Iana, additional, Samardjieva, Martina, additional, Barbieri, Andrea, additional, Morrone, Doralisa, additional, Lorenzoni, Valentina, additional, Prota, Costantina, additional, Villari, Bruno, additional, Antonini-Canterin, Francesco, additional, Pepi, Mauro, additional, Carpeggiani, Clara, additional, Pellikka, Patricia A, additional, and Picano, Eugenio, additional

Published
2021
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29. Prognostic value of reduced heart rate reserve during exercise in hypertrophic cardiomyopathy

Author

Ciampi, Quirino, Olivotto, Iacopo, Peteiro, Jesus, D’Alfonso, Maria, Mori, Fabio, Tassetti, Luigi, Milazzo, Alessandra, Monserrat, Lorenzo, Fernandez, Xusto, Pálinkás, Attila, Pálinkás, Eszter, Sepp, Róbert, Re, Federica, Cortigiani, Lauro, Tesic, Milorad, Djordjevic-Dikic, Ana, Beleslin, Branko, Losi, Mariangela, Canciello, Grazia, Betocchi, Sandro, Lopes, Luis, Cruz, Ines, Cotrim, Carlos, Torres, Marco, Bellagamba, Clarissa, Heyning, Caroline Van De, Varga, Albert, Ágoston, Gergely, Villari, Bruno, Lorenzoni, Valentina, Carpeggiani, Clara, Picano, Eugenio, (SIECVI), the Stress Echo 2020 Study Group on behalf of the Italian Society of Echocardiography and Cardiovascular Imaging, Stress Echo 2020 Study Group, and Italian Society of Echocardiography and Cardiovascular Imaging (SIECVI)

Subjects
medicine.medical_specialty, Autonomic dysfunction, Hypertrophic cardiomyopathy, Stress echocardiography, lcsh:Medicine, Ventricular outflow tract obstruction, 030204 cardiovascular system & hematology, Article, 03 medical and health sciences, 0302 clinical medicine, Interquartile range, Internal medicine, Heart rate, medicine, 030212 general & internal medicine, Treadmill, business.industry, lcsh:R, Hazard ratio, General Medicine, Odds ratio, medicine.disease, Quartile, Cardiology, Human medicine, medicine.symptom, business
Abstract

Background: Sympathetic dysfunction can be evaluated by heart rate reserve (HRR) with exercise test. Objectives: To determine the value of HRR in predicting outcome of patients with hypertrophic cardiomyopathy (HCM). Methods: We enrolled 917 HCM patients (age = 49 ± 15 years, 516 men) assessed with exercise stress echocardiography (ESE) in 11 centres. ESE modality was semi-supine bicycle in 51 patients (6%), upright bicycle in 476 (52%), and treadmill in 390 (42%). During ESE, we assessed left ventricular outflow tract obstruction (LVOTO), stress-induced new regional wall motion abnormalities (RWMA), and HRR (peak/rest heart rate, HR). By selection, all patients completed the follow-up. Mortality was the predetermined outcome measure Results: During ESE, RWMA occurred in 22 patients (2.4%) and LVOTO (≥50 mmHg) in 281 (30.4%). HRR was 1.90 ± 0.40 (lowest quartile ≤ 1.61, highest quartile &gt, 2.13). Higher resting heart rate (odds ratio 1.027, 95% CI: 1.018–1.036, p &lt, 0.001), older age (odds ratio 1.021, 95% CI: 1.009–1.033, p &lt, 0.001), lower exercise tolerance (mets, odds ratio 0.761, 95% CI: 0.708–0.817, p &lt, 0.001) and resting LVOTO (odds ratio 1.504, 95% CI: 1.043–2.170, p = 0.029) predicted a reduced HRR. During a median follow-up of 89 months (interquartile range: 36–145 months), 90 all-cause deaths occurred. At multivariable analysis, lowest quartile HRR (Hazard ratio 2.354, 95% CI 1.116–4.968 p = 0.025) and RWMA (Hazard ratio 3.279, 95% CI 1.441–7.461 p = 0.004) independently predicted death, in addition to age (Hazard ratio 1.064, 95% CI 1.043–1.085 p &lt, 0.001) and maximal wall thickness (Hazard ratio 1.081, 95% CI 1.037–1.128, p &lt, 0.001). Conclusions: A blunted HRR during ESE predicts survival independently of RWMA in HCM patients.

Published
2021

30. Stress Echo 2030: The Novel ABCDE-(FGLPR) Protocol to Define the Future of Imaging

Author

Picano, Eugenio, Ciampi, Quirino, Cortigiani, Lauro, Arruda-Olson, Adelaide M., Borguezan-Daros, Clarissa, Silva Pretto, José Luis de Castro, Cocchia, Rosangela, Bossone, Eduardo, Merli, Elisa, Kane, Garvan C., Varga, Albert, Agoston, Gergely, Scali, Maria Chiara, Morrone, Doralisa, Simova, Iana, Samardjieva, Martina, Boschenko, Alla, Ryabova, Tamara, Vrublevsky, Alexander, Palinkas, Attila, Palinkas, Eszter D., Sepp, Robert, Torres, Marco A.R., Villarraga, Hector R., Kovacevic Preradovic, Tamara, Citro, Rodolfo, Amor, Miguel, Mosto, Hugo, Salamè, Michael, Leeson, Paul, Mangia, Cristina, Gaibazzi, Nicola, Tuttolomondo, Domenico, Prota, Constantina, Peteiro-Vázquez, Jesús, Van de Heyning, Caroline M., D'Andrea, Antonello, Rigo, Fausto, Nikolic, Aleksandra, Ostojic, Miodrag, Lowenstein, Jorge, Arbucci, Rosina, Lowenstein Haber, Diego M., Merlo, Pablo M., Wierzbowska-Drabik, Karina, Kasprzak, Jaroslaw D., Haberka, Maciej, Camarozano, Ana Cristina, Ratanasit, Nithima, Mori, Fabio, D'Alfonso, Maria Grazia, Tassetti, Luigi, Milazzo, Alessandra, Olivotto, Iacopo, Marchi, Alberto, Rodríguez-Zanella, Hugo, Zagatina, Angela, Padang, Ratnasari, Dekleva, Milica, Djordievic-Dikic, Ana, Boskovic, Nikola, Tesic, Milorad, Giga, Vojislav, Belesin, Branko, Di Salvo, Giovanni, Lorenzoni, Valentina, Cameli, Matteo, Mandoli, Giulia Elena, Bombardini, Tonino, Caso, Pio, Celutkiene, Jelena, Barbieri, Andrea, Benfari, Giovanni, Bartolacelli, Ylenia, Malagoli, Alessandro, Bursi, Francesca, Mantovani, Francesca, Villari, Bruno, Russo, Antonello, De Nes, Michelle, Carpeggiani, Clara, Monte, Ines, Re, Federica, Cotrim, Carlos, Bilardo, Giuseppe, Saad, Ariel K., Karuzas, Arnas, Matuliauskas, Dovydas, Colonna, Paolo, Antonini-Canterin, Francesco, Pepi, Mauro, Pellikka, Patricia A., Picano, Eugenio, Ciampi, Quirino, Cortigiani, Lauro, Arruda-Olson, Adelaide M., Borguezan-Daros, Clarissa, Silva Pretto, José Luis de Castro, Cocchia, Rosangela, Bossone, Eduardo, Merli, Elisa, Kane, Garvan C., Varga, Albert, Agoston, Gergely, Scali, Maria Chiara, Morrone, Doralisa, Simova, Iana, Samardjieva, Martina, Boschenko, Alla, Ryabova, Tamara, Vrublevsky, Alexander, Palinkas, Attila, Palinkas, Eszter D., Sepp, Robert, Torres, Marco A.R., Villarraga, Hector R., Kovacevic Preradovic, Tamara, Citro, Rodolfo, Amor, Miguel, Mosto, Hugo, Salamè, Michael, Leeson, Paul, Mangia, Cristina, Gaibazzi, Nicola, Tuttolomondo, Domenico, Prota, Constantina, Peteiro-Vázquez, Jesús, Van de Heyning, Caroline M., D'Andrea, Antonello, Rigo, Fausto, Nikolic, Aleksandra, Ostojic, Miodrag, Lowenstein, Jorge, Arbucci, Rosina, Lowenstein Haber, Diego M., Merlo, Pablo M., Wierzbowska-Drabik, Karina, Kasprzak, Jaroslaw D., Haberka, Maciej, Camarozano, Ana Cristina, Ratanasit, Nithima, Mori, Fabio, D'Alfonso, Maria Grazia, Tassetti, Luigi, Milazzo, Alessandra, Olivotto, Iacopo, Marchi, Alberto, Rodríguez-Zanella, Hugo, Zagatina, Angela, Padang, Ratnasari, Dekleva, Milica, Djordievic-Dikic, Ana, Boskovic, Nikola, Tesic, Milorad, Giga, Vojislav, Belesin, Branko, Di Salvo, Giovanni, Lorenzoni, Valentina, Cameli, Matteo, Mandoli, Giulia Elena, Bombardini, Tonino, Caso, Pio, Celutkiene, Jelena, Barbieri, Andrea, Benfari, Giovanni, Bartolacelli, Ylenia, Malagoli, Alessandro, Bursi, Francesca, Mantovani, Francesca, Villari, Bruno, Russo, Antonello, De Nes, Michelle, Carpeggiani, Clara, Monte, Ines, Re, Federica, Cotrim, Carlos, Bilardo, Giuseppe, Saad, Ariel K., Karuzas, Arnas, Matuliauskas, Dovydas, Colonna, Paolo, Antonini-Canterin, Francesco, Pepi, Mauro, and Pellikka, Patricia A.

Abstract

[Abstract] With stress echo (SE) 2020 study, a new standard of practice in stress imaging was developed and disseminated: the ABCDE protocol for functional testing within and beyond CAD. ABCDE protocol was the fruit of SE 2020, and is the seed of SE 2030, which is articulated in 12 projects: 1-SE in coronary artery disease (SECAD); 2-SE in diastolic heart failure (SEDIA); 3-SE in hypertrophic cardiomyopathy (SEHCA); 4-SE post-chest radiotherapy and chemotherapy (SERA); 5-Artificial intelligence SE evaluation (AI-SEE); 6-Environmental stress echocardiography and air pollution (ESTER); 7-SE in repaired Tetralogy of Fallot (SETOF); 8-SE in post-COVID-19 (SECOV); 9: Recovery by stress echo of conventionally unfit donor good hearts (RESURGE); 10-SE for mitral ischemic regurgitation (SEMIR); 11-SE in valvular heart disease (SEVA); 12-SE for coronary vasospasm (SESPASM). The study aims to recruit in the next 5 years (2021-2025) ≥10,000 patients followed for ≥5 years (up to 2030) from ≥20 quality-controlled laboratories from ≥10 countries. In this COVID-19 era of sustainable health care delivery, SE2030 will provide the evidence to finally recommend SE as the optimal and versatile imaging modality for functional testing anywhere, any time, and in any patient.

Published
2021

34. Stress echo in Italy

Author

Ciampi, Quirino, Citro, Rodolfo, Severino, Sergio, Labanti, Graziana, Cortigiani, Lauro, Sicari, Rosa, Gaibazzi, Nicola, Galderisi, Maurizio, Bossone, Eduardo, Colonna, Paolo, Picano, Eugenio, D'Andrea, Antonello, Scali, Maria Chiara, Olivotto, Iacopo, Mori, Fabio, Costantino, Marco Fabio, Pratali, Lorenza, Di Salvo, Giovanni, Ferrara, Francesco, Gargani, Luna, Rigo, Fausto, Limongelli, Giuseppe, Pacileo, Giuseppe, Andreassi, Maria Grazia, Pinamonti, Bruno, Massa, Laura, Torres, Marco A. R., Miglioranza, Marcelo H., Daros, Clarissa Borguezan, De Castro E Silva Pretto, José Luis, Beleslin, Branko, Djordjevic-DIkic, Ana, Varga, Albert, Palinkas, Attila, Agoston, Gergely, Gregori, Dario, Trambaiolo, Paolo, Arystan, Ayana, Paterni, Marco, Carpeggiani, Clara, Ciampi, Quirino, Citro, Rodolfo, Severino, Sergio, Labanti, Graziana, Cortigiani, Lauro, Sicari, Rosa, Gaibazzi, Nicola, Galderisi, Maurizio, Bossone, Eduardo, Colonna, Paolo, Picano, Eugenio, D'Andrea, Antonello, Scali, Maria Chiara, Olivotto, Iacopo, Mori, Fabio, Costantino, Marco Fabio, Pratali, Lorenza, Di Salvo, Giovanni, Ferrara, Francesco, Gargani, Luna, Rigo, Fausto, Limongelli, Giuseppe, Pacileo, Giuseppe, Andreassi, Maria Grazia, Pinamonti, Bruno, Massa, Laura, Torres, Marco A. R., Miglioranza, Marcelo H., Daros, Clarissa Borguezan, De Castro E Silva Pretto, José Lui, Beleslin, Branko, Djordjevic-DIkic, Ana, Varga, Albert, Palinkas, Attila, Agoston, Gergely, Gregori, Dario, Trambaiolo, Paolo, Arystan, Ayana, Paterni, Marco, and Carpeggiani, Clara

Subjects
medicine.medical_specialty, business.industry, Myocardial Ischemia, MEDLINE, General Medicine, 030204 cardiovascular system & hematology, Stress, Echocardiography, Stress, Humans, Italy, Practice Guidelines as Topic, Societies, Medical, Cardiology and Cardiovascular Medicine, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, Echocardiography, Stress Echo, Medical, Medicine, 030212 general & internal medicine, State (computer science), Societies, business
Published
2017
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36. Lung Ultrasound and Pulmonary Congestion During Stress Echocardiography

Author

Scali, Maria Chiara, primary, Zagatina, Angela, additional, Ciampi, Quirino, additional, Cortigiani, Lauro, additional, D'Andrea, Antonello, additional, Daros, Clarissa Borguezan, additional, Zhuravskaya, Nadezhda, additional, Kasprzak, Jaroslaw D., additional, Wierzbowska-Drabik, Karina, additional, Luis de Castro e Silva Pretto, José, additional, Djordjevic-Dikic, Ana, additional, Beleslin, Branko, additional, Petrovic, Marija, additional, Boskovic, Nikola, additional, Tesic, Milorad, additional, Monte, Ines, additional, Simova, Iana, additional, Vladova, Martina, additional, Boshchenko, Alla, additional, Vrublevsky, Alexander, additional, Citro, Rodolfo, additional, Amor, Miguel, additional, Vargas Mieles, Paul E., additional, Arbucci, Rosina, additional, Merlo, Pablo Martin, additional, Lowenstein Haber, Diego M., additional, Dodi, Claudio, additional, Rigo, Fausto, additional, Gligorova, Suzana, additional, Dekleva, Milica, additional, Severino, Sergio, additional, Lattanzi, Fabio, additional, Morrone, Doralisa, additional, Galderisi, Maurizio, additional, Torres, Marco A.R., additional, Salustri, Alessandro, additional, Rodrìguez-Zanella, Hugo, additional, Costantino, Fabio Marco, additional, Varga, Albert, additional, Agoston, Gergely, additional, Bossone, Eduardo, additional, Ferrara, Francesco, additional, Gaibazzi, Nicola, additional, Celutkiene, Jelena, additional, Haberka, Maciej, additional, Mori, Fabio, additional, D'Alfonso, Maria Grazia, additional, Reisenhofer, Barbara, additional, Camarozano, Ana Cristina, additional, Miglioranza, Marcelo Haertel, additional, Szymczyk, Ewa, additional, Wejner-Mik, Paulina, additional, Wdowiak-Okrojek, Katarzyna, additional, Preradovic-Kovacevic, Tamara, additional, Bombardini, Tonino, additional, Ostojic, Miodrag, additional, Nikolic, Aleksandra, additional, Re, Federica, additional, Barbieri, Andrea, additional, Di Salvo, Giovanni, additional, Merli, Elisa, additional, Colonna, Paolo, additional, Lorenzoni, Valentina, additional, De Nes, Michele, additional, Paterni, Marco, additional, Carpeggiani, Clara, additional, Lowenstein, Jorge, additional, and Picano, Eugenio, additional

Published
2020
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37. Additional prognostic value of heart rate reserve over left ventricular contractile reserve and coronary flow velocity reserve in diabetic patients with negative vasodilator stress echocardiography by regional wall motion criteria.

Author

Cortigiani, Lauro, Ciampi, Quirino, Carpeggiani, Clara, Lisi, Cristiano, Bovenzi, Francesco, and Picano, Eugenio

Subjects
LEFT heart ventricle, PHYSIOLOGICAL stress, ECHOCARDIOGRAPHY, CONFIDENCE intervals, DIABETES, CORONARY circulation, DIPYRIDAMOLE, HEART rate monitoring, VASODILATORS, DESCRIPTIVE statistics, LONGITUDINAL method, PROPORTIONAL hazards models
Abstract

Aims  In diabetic patients, a blunted left ventricular contractile reserve (LVCR) and/or a reduced coronary flow velocity reserve (CFVR) identify patients at higher risk in spite of stress echocardiography (SE) negative for ischaemia. Cardiac autonomic dysfunction contributes to risk profile independently of inducible ischaemia and can be assessed with heart rate reserve (HRR). We sought to assess the added prognostic value of HRR to LVCR and CFVR in diabetic patients with non-ischaemic SE. Methods and results  Six-hundred and thirty-six diabetic patients (age 68 ± 9 years, 396 men, ejection fraction 58 ± 10%) with sinus rhythm on resting electrocardiogram underwent dipyridamole SE in a two-centre prospective study with assessment of wall motion, force-based LVCR (stress/rest ratio, normal value > 1.1), CFVR of the left anterior descending coronary artery (stress/rest ratio, normal value >2.0), and HRR (stress/rest ratio, normal value >1.22). All-cause death was the only considered endpoint. During a median follow-up of 39 months, 94 (15%) patients died. Independent predictors of death were abnormal CFVR [hazard ratio (HR) 1.59, 95% confidence interval (CI) 1.0–2.52, P  = 0.05], reduced LVCR (HR 1.76, 95% CI 1.15–2.69, P  = 0.009), and blunted HRR (HR 1.92, 95% CI 1.24–2.96, P  = 0.003). Eight-year death rate was 9% for patients with triple negativity (n  = 252; 40%), 18% for those with single positivity (n  = 216; 34%), 36% with double positivity (n  = 124; 19%), and 64% for triple positivity (n  = 44; 7%) (P  < 0.0001). Conclusion  Diabetic patients with dipyridamole SE negative for ischaemia still may have a significant risk in presence of an abnormal LVCR and/or CFVR and/or HRR, which assess the underlying myocardial, microvascular, and cardiac autonomic dysfunction. Clinical trials Gov Identifier NCT 030.49995. [ABSTRACT FROM AUTHOR]

Published
2022
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38. Subsequent Event Risk in Individuals With Established Coronary Heart Disease Design and Rationale of the GENIUS-CHD Consortium

Author

Patel, Riyaz, Tragante, Vinicius, Schmidt, Amand F., McCubrey, Raymond O., Holmes, Michael V., Howe, Laurence J., Direk, Kenan, Åkerblom, Axel, Leander, Karin, Virani, Salim S., Kaminski, Karol A., Muehlschlegel, Jochen D., Allayee, Hooman, Almgren, Peter, Alver, Maris, Baranova, Ekaterina V., Behlouli, Hassan, Boeckx, Bram, Braund, Peter S., Breitling, Lutz P., Delgado, Graciela, Duarte, Nubia E., Dubé, Marie-Pierre, Dufresne, Line, Eriksson, Niclas, Foco, Luisa, Scholz, Markus, Gijsberts, Crystel M., Glinge, Charlotte, Gong, Yan, Hartiala, Jaana, Heydarpour, Mahyar, Hubacek, Jaroslav A., Kleber, Marcus, Kofink, Daniel, Kotti, Salma, Kuukasjärvi, Pekka, Lee, Vei-Vei, Leiherer, Andreas, Lenzini, Petra A., Levin, Daniel, Lyytikäinen, Leo-Pekka, Martinelli, Nicola, Mons, Ute, Nelson, Christopher P., Nikus, Kjell, Pilbrow, Anna P., Ploski, Rafal, Sun, Yan V., Tanck, Michael W.T., Tang, W H Wilson, Trompet, Stella, van der Laan, Sander W., Van Setten, Jessica, Vilmundarson, Ragnar O., Viviani Anselmi, Chiara, Vlachopoulou, Efthymia, Al Ali, Lawien, Boerwinkle, Eric, Briguori, Carlo, Carlquist, John F., Carruthers, Kathryn F., Casu, Gavino, Deanfield, John, Deloukas, Panos, Dudbridge, Frank, Engström, Thomas, Fitzpatrick, Natalie, Fox, Kim, Gigante, Bruna, James, Stefan, Lokki, Marja-Liisa, Lotufo, Paulo A., Marziliano, Nicola, Mordi, Ify R., Muhlestein, Joseph B., Newton-Cheh, Christopher, Pitha, Jan, Saely, Christoph H., Samman-Tahhan, Ayman, Sandesara, Pratik B., Teren, Andrej, Timmis, Adam, Van de Werf, Frans, Wauters, Els, Wilde, Arthur A.M., Ford, Ian, Stott, David J., Algra, Ale, Andreassi, Maria G., Ardissino, Diego, Arsenault, Benoit J., Ballantyne, Christie M., Bergmeijer, Thomas O., Bezzina, Connie R., Body, Simon C., Boersma, Eric H., Bogaty, Peter, Bots, Michiel, Brenner, Hermann, Brugts, Jasper J., Burkhardt, Ralph, Carpeggiani, Clara, Condorelli, Gianluigi, Cooper-DeHoff, Rhonda M., Cresci, Sharon, Danchin, Nicolas, de Faire, Ulf, Doughty, Robert N., Drexel, Heinz, Engert, James C., Fox, Keith A.A., Girelli, Domenico, Grobbee, Diederick E., Hagström, Emil, Hazen, Stanley L., Held, Claes, Hemingway, Harry, Hoefer, Imo E., Hovingh, G. Kees, Jabbari, Reza, Johnson, Julie A., Jukema, J. Wouter, Kaczor, Marcin P., Kähönen, Mika, Kettner, Jiri, Kiliszek, Marek, Klungel, Olaf H., Lagerqvist, Bo, Lambrechts, Diether, Laurikka, Jari O., Lehtimäki, Terho, Lindholm, Daniel, Mahmoodi, B.K., Maitland-van der Zee, Anke H., McPherson, Ruth, Melander, Olle, Metspalu, Andres, Niemcunowicz-Janica, Anna, Olivieri, Oliviero, Opolski, Grzegorz, Palmer, Colin N., Pasterkamp, Gerard, Pepine, Carl J., Pereira, Alexandre C., Pilote, Louise, Quyyumi, Arshed A., Richards, A. Mark, Sanak, Marek, Siegbahn, Agneta, Simon, Tabassome, Sinisalo, Juha, Smith, J. Gustav, Spertus, John A., Stender, Steen, Stewart, Alexandre F.R., Szczeklik, Wojciech, Szpakowicz, Anna, Tardif, Jean-Claude, Ten Berg, Jurriën M., Tfelt-Hansen, Jacob, Thanassoulis, George, Thiery, Joachim, Torp-Pedersen, Christian, van der Graaf, Yolanda, Visseren, Frank L.J., Waltenberger, Johannes, Weeke, Peter E., Van der Harst, Pim, Lang, Chim C., Sattar, Naveed, Cameron, Vicky A., Anderson, Jeffrey L., Brophy, James M., Paré, Guillaume, Horne, Benjamin D., März, Winfried, Wallentin, Lars, Samani, Nilesh J., Hingorani, Aroon D., Asselbergs, Folkert W., and Cardiovascular Centre (CVC)

Subjects
Adult, Male, Cardiac & Cardiovascular Systems, CARDIOVASCULAR MORTALITY, Coronary Disease, BIOBANK, Article, Sex Factors, Risk Factors, Journal Article, Humans, ARTERY-DISEASE, Cardiac and Cardiovascular Systems, genetics, Aged, Proportional Hazards Models, Genetics & Heredity, Kardiologi, Science & Technology, Smoking, Age Factors, Middle Aged, BODY-MASS INDEX, myocardial infarction, MYOCARDIAL-INFARCTION, PUBLIC-HEALTH, Cardiovascular System & Cardiology, Female, prognosis, Life Sciences & Biomedicine, coronary artery disease, secondary prevention
Abstract

BACKGROUND: The Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD. METHODS: The consortium currently includes 57 studies from 18 countries, recruiting 185 614 participants with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events. RESULTS: Enrollment into the individual studies took place between 1985 to present day with a duration of follow-up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%-100%), mostly male (44%-91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (hazard ratio, 1.15; 95% CI, 1.14-1.16) per 5-year increase, male sex (hazard ratio, 1.17; 95% CI, 1.13-1.21) and smoking (hazard ratio, 1.43; 95% CI, 1.35-1.51) with risk of subsequent CHD death or myocardial infarction and differing associations with other individual and composite cardiovascular endpoints. CONCLUSIONS: GENIUS-CHD is a global collaboration seeking to elucidate genetic and nongenetic determinants of subsequent event risk in individuals with established CHD, to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators. ispartof: CIRCULATION-GENOMIC AND PRECISION MEDICINE vol:12 issue:4 ispartof: location:United States status: published

Published
2019
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39. Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events A GENIUS-CHD Study of Individual Participant Data

Author

Patel, Riyaz S., Schmidt, Amand F., Tragante, Vinicius, McCubrey, Raymond O., Holmes, Michael, V, Howe, Laurence J., Direk, Kenan, Åkerblom, Axel, Leander, Karin, Virani, Salim S., Kaminski, Karol A., Muehlschlegel, Jochen D., Dube, Marie-Pierre, Allayee, Hooman, Almgren, Peter, Alver, Maris, Baranova, Ekaterina, V, Behlouli, Hassan, Boeckx, Bram, Braund, Peter S., Breitling, Lutz P., Delgado, Graciela, Duarte, Nubia E., Dufresne, Line, Eriksson, Niclas, Foco, Luisa, Gijsberts, Crystel M., Gong, Yan, Hartiala, Jaana, Heydarpour, Mahyar, Hubacek, Jaroslav A., Kleber, Marcus, Kofink, Daniel, Kuukasjarvi, Pekka, Lee, Vei-Vei, Leiherer, Andreas, Lenzini, Petra A., Levin, Daniel, Lyytikainen, Leo-Pekka, Martinelli, Nicola, Mons, Ute, Nelson, Christopher P., Nikus, Kjell, Pilbrow, Anna P., Ploski, Rafal, Sun, Yan, V, Tanck, Michael W. T., Tang, W. H. Wilson, Trompet, Stella, van der Laan, Sander W., van Setten, Jessica, Vilmundarson, Ragnar O., Anselmi, Chiara Viviani, Vlachopoulou, Efthymia, Boerwinkle, Eric, Briguori, Carlo, Carlquist, John F., Carruthers, Kathryn F., Casu, Gavino, Deanfield, John, Deloukas, Panos, Dudbridge, Frank, Fitzpatrick, Natalie, Gigante, Bruna, James, Stefan, Lokki, Marja-Liisa, Lotufo, Paulo A., Marziliano, Nicola, Mordi, Ify R., Muhlestein, Joseph B., Cheh, Chris Newton, Pitha, Jan, Saely, Christoph H., Samman-Tahhan, Ayman, Sandesara, Pratik B., Teren, Andrej, Timmis, Adam, Van de Werf, Frans, Wauters, Els, Wilde, Arthur A. M., Ford, Ian, Stott, David J., Algra, Ale, Andreassi, Maria G., Ardissino, Diego, Arsenault, Benoit J., Ballantyne, Christie M., Bergmeijer, Thomas O., Bezzina, Connie R., Body, Simon C., Bogaty, Peter, de Borst, Gert J., Brenner, Hermann, Burkhardt, Ralph, Carpeggiani, Clara, Condorelli, Gianluigi, Cooper-DeHoff, Rhonda M., Cresci, Sharon, de Faire, Ulf, Doughty, Robert N., Drexel, Heinz, Engert, James C., Fox, Keith A. A., Girelli, Domenico, Hagström, Emil, Hazen, Stanley L., Held, Claes, Hemingway, Harry, Hoefer, Imo E., Hovingh, G. Kees, Johnson, Julie A., De Jong, Pim A., Jukema, J. Wouter, Kaczor, Marcin P., Kahonen, Mika, Kettner, Jiri, Kiliszek, Marek, Klungel, Olaf H., Lagerqvist, Bo, Lambrechts, Diether, Laurikka, Jari O., Lehtimaki, Terho, Lindholm, Daniel, Mahmoodi, Bakhtawar K., Maitland-van der Zee, Anke H., McPherson, Ruth, Melander, Olle, Metspalu, Andres, Pepinski, Witold, Olivieri, Oliviero, Opolski, Grzegorz, Palmer, Colin N., Pasterkamp, Gerard, Pepine, Carl J., Pereira, Alexandre C., Note, Louise, Quyyumi, Arshed A., Richards, A. Mark, Sanak, Marek, Scholz, Markus, Siegbahn, Agneta, Sinisalo, Juha, Smith, J. Gustav, Spertus, John A., Stewart, Alexandre F. R., Szczeklik, Wojciech, Szpakowicz, Anna, ten Berg, Jurrien M., Thanassoulis, George, Thieiy, Joachim, van der Graaf, Yolanda, Visseren, Frank L. J., Waltenberger, Johannes, Van der Harst, Pim, Tardif, Jean-Claude, Sattar, Naveed, Lang, Chim C., Pare, Guillaume, Brophy, James M., Anderson, Jeffrey L., Maerz, Winfried, Wallentin, Lars, Cameron, Vicky A., Horne, Benjamin D., Samani, Nilesh J., Hingorani, Aroon D., and Asselbergs, Folkert W.

Subjects
Genetics & Heredity, RISK, Kardiologi, Science & Technology, Cardiac & Cardiovascular Systems, VARIANTS, RECURRENT MYOCARDIAL-INFARCTION, myocardial infarction, risk factor, BIAS, Cardiovascular System & Cardiology, LOCUS, Cardiac and Cardiovascular Systems, cardiovascular diseases, chromosome, genetic, variation, Medical Genetics, Life Sciences & Biomedicine, secondary prevention, Medicinsk genetik
Abstract

BACKGROUND: Genetic variation at chromosome 9p21 is a recognized risk factor for coronary heart disease (CHD). However, its effect on disease progression and subsequent events is unclear, raising questions about its value for stratification of residual risk. METHODS: A variant at chromosome 9p21 (rs1333049) was tested for association with subsequent events during follow-up in 103 357 Europeans with established CHD at baseline from the GENIUS-CHD (Genetics of Subsequent Coronary Heart Disease) Consortium (73.1% male, mean age 62.9 years). The primary outcome, subsequent CHD death or myocardial infarction (CHD death/myocardial infarction), occurred in 13 040 of the 93 115 participants with available outcome data. Effect estimates were compared with case/control risk obtained from the CARDIoGRAMplusC4D consortium (Coronary Artery Disease Genome-wide Replication and Meta-analysis [CARDIoGRAM] plus The Coronary Artery Disease [C4D] Genetics) including 47 222 CHD cases and 122 264 controls free of CHD. RESULTS: Meta-analyses revealed no significant association between chromosome 9p21 and the primary outcome of CHD death/myocardial infarction among those with established CHD at baseline (GENIUS-CHD odds ratio, 1.02; 95% CI, 0.99-1.05). This contrasted with a strong association in CARDIoGRAMPlusC4D odds ratio 1.20; 95% CI, 1.18-1.22; P for interaction

Published
2019

40. Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events

Author

Patel, Riyaz S, Schmidt, Amand F, Tragante, Vinicius, McCubrey, Raymond O, Holmes, Michael V, Howe, Laurence J, Direk, Kenan, Åkerblom, Axel, Leander, Karin, Virani, Salim S, Kaminski, Karol A, Muehlschlegel, Jochen D, Dubé, Marie-Pierre, Allayee, Hooman, Almgren, Peter, Alver, Maris, Baranova, Ekaterina V, Behlouli, Hassan, Boeckx, Bram, Braund, Peter S, Breitling, Lutz P, Delgado, Graciela, Duarte, Nubia E, Dufresne, Line, Eriksson, Niclas, Foco, Luisa, Gijsberts, Crystel M, Gong, Yan, Hartiala, Jaana, Heydarpour, Mahyar, Hubacek, Jaroslav A, Kleber, Marcus, Kofink, Daniel, Kuukasjärvi, Pekka, Lee, Vei-Vei, Leiherer, Andreas, Lenzini, Petra A, Levin, Daniel, Lyytikäinen, Leo-Pekka, Martinelli, Nicola, Mons, Ute, Nelson, Christopher P, Nikus, Kjell, Pilbrow, Anna P, Ploski, Rafal, Sun, Yan V, Tanck, Michael WT, Tang, WH Wilson, Trompet, Stella, van der Laan, Sander W, van Setten, Jessica, Vilmundarson, Ragnar O, Viviani Anselmi, Chiara, Vlachopoulou, Efthymia, Boerwinkle, Eric, Briguori, Carlo, Carlquist, John F, Carruthers, Kathryn F, Casu, Gavino, Deanfield, John, Deloukas, Panos, Dudbridge, Frank, Fitzpatrick, Natalie, Gigante, Bruna, James, Stefan, Lokki, Marja-Liisa, Lotufo, Paulo A, Marziliano, Nicola, Mordi, Ify R, Muhlestein, Joseph B, Newton Cheh, Chris, Pitha, Jan, Saely, Christoph H, Samman-Tahhan, Ayman, Sandesara, Pratik B, Teren, Andrej, Timmis, Adam, Van de Werf, Frans, Wauters, Els, Wilde, Arthur AM, Ford, Ian, Stott, David J, Algra, Ale, Andreassi, Maria G, Ardissino, Diego, Arsenault, Benoit J, Ballantyne, Christie M, Bergmeijer, Thomas O, Bezzina, Connie R, Body, Simon C, Bogaty, Peter, de Borst, Gert J, Brenner, Hermann, Burkhardt, Ralph, Carpeggiani, Clara, Condorelli, Gianluigi, Cooper-DeHoff, Rhonda M, Cresci, Sharon, de Faire, Ulf, Doughty, Robert N, Drexel, Heinz, Engert, James C, Fox, Keith AA, Girelli, Domenico, Hagström, Emil, Hazen, Stanley L, Held, Claes, Hemingway, Harry, Hoefer, Imo E, Hovingh, G Kees, Johnson, Julie A, de Jong, Pim A, Jukema, J Wouter, Kaczor, Marcin P, Kähönen, Mika, Kettner, Jiri, Kiliszek, Marek, Klungel, Olaf H, Lagerqvist, Bo, Lambrechts, Diether, Laurikka, Jari O, Lehtimäki, Terho, Lindholm, Daniel, Mahmoodi, Bakhtawar K, Maitland-van der Zee, Anke H, McPherson, Ruth, Melander, Olle, Metspalu, Andres, Pepinski, Witold, Olivieri, Oliviero, Opolski, Grzegorz, Palmer, Colin N, Pasterkamp, Gerard, Pepine, Carl J, Pereira, Alexandre C, Pilote, Louise, Quyyumi, Arshed A, Richards, A Mark, Sanak, Marek, Scholz, Markus, Siegbahn, Agneta, Sinisalo, Juha, Smith, J Gustav, Spertus, John A, Stewart, Alexandre FR, Szczeklik, Wojciech, Szpakowicz, Anna, Ten Berg, Jurriën M, Thanassoulis, George, Thiery, Joachim, van der Graaf, Yolanda, Visseren, Frank LJ, Waltenberger, Johannes, CARDIoGRAMPlusC4D Consortium, Van der Harst, Pim, Tardif, Jean-Claude, Sattar, Naveed, Lang, Chim C, Pare, Guillaume, Brophy, James M, Anderson, Jeffrey L, März, Winfried, Wallentin, Lars, Cameron, Vicky A, Horne, Benjamin D, Samani, Nilesh J, Hingorani, Aroon D, and Asselbergs, Folkert W

Subjects
cardiovascular diseases
Abstract

BACKGROUND: Genetic variation at chromosome 9p21 is a recognized risk factor for coronary heart disease (CHD). However, its effect on disease progression and subsequent events is unclear, raising questions about its value for stratification of residual risk. METHODS: A variant at chromosome 9p21 (rs1333049) was tested for association with subsequent events during follow-up in 103?357 Europeans with established CHD at baseline from the GENIUS-CHD (Genetics of Subsequent Coronary Heart Disease) Consortium (73.1% male, mean age 62.9 years). The primary outcome, subsequent CHD death or myocardial infarction (CHD death/myocardial infarction), occurred in 13?040 of the 93?115 participants with available outcome data. Effect estimates were compared with case/control risk obtained from the CARDIoGRAMplusC4D consortium (Coronary Artery Disease Genome-wide Replication and Meta-analysis [CARDIoGRAM] plus The Coronary Artery Disease [C4D] Genetics) including 47?222 CHD cases and 122?264 controls free of CHD. RESULTS: Meta-analyses revealed no significant association between chromosome 9p21 and the primary outcome of CHD death/myocardial infarction among those with established CHD at baseline (GENIUS-CHD odds ratio, 1.02; 95% CI, 0.99-1.05). This contrasted with a strong association in CARDIoGRAMPlusC4D odds ratio 1.20; 95% CI, 1.18-1.22; P for interaction

Published
2019

41. Hierarchical structure of personality in patients with acute myocardial infarction

Author

Bonaguidi, Franco, Michelassi, Claudio, Trivella, M. Giovanna, Carpeggiani, Clara, and L'Abbate, Antonio

Subjects
Personality -- Health aspects, Cardiac patients -- Psychological aspects, Heart attack -- Psychological aspects, Sixteen personality factor questionnaire -- Analysis, Psychology and mental health
Abstract

The personalities in coronary heart disease have often been investigated using the Sixteen Personality Factor Questionnaire (16 PF) of Cattell. The aims of this study were to verify the third-order factor structure of 16 PF and to assess the third-order factors in a group of patients with acute myocardial infarction as compared with a group of normal subjects. The primary 16 factor scores of the over-all population of infarcted patients and normal subjects were factored and the results rotated obliquely (dquart solution) to produce nine second-order factors. In a second step the nine second-order factors extracted were processed again by factor analysis and the third-order structure was achieved. The five third-order factors obtained were named Inhibition ([Alpha]), Internal Feeling ([Beta]), Maladaptation ([Gamma]), Self-concern and Control ([Delta]), plus an Unidentified Factor ([Epsilon]). The patients with acute myocardial infarction were significantly different from normal subjects in scores on [Alpha], [Beta], [Gamma], and [Delta]. The profile analysis of these four third-order psychological variables differentiated the two groups. In conclusion, the patients with acute myocardial infarction are characterized by difficulties in communication, emotional expression, and adaptation to stress and by a tendency to strong self-control and poor attention to their internal feelings.

Published
1997

43. Cattell's 16 PF and PSY inventory: relationship between personality traits and behavioral responses in patients with acute myocardial infarction

Author

Bonaguidi, Franco, Michelassi, Claudio, Trivella, M. Giovanna, Carpeggiani, Clara, Pruneti, Carlo A., Cesana, Giancarlo, and L'Abbate, Antonio

Subjects
Cardiac patients -- Psychological aspects, Personality tests -- Validity, Compulsive personality disorder -- Testing, Hostility (Psychology) -- Testing, Stress (Psychology) -- Testing, Anger -- Testing, Psychology and mental health
Abstract

The aim of this study was to investigate the relationships between personality and behavioral responses in patients with acute myocardial infarction. In a first step, a new instrument (PSY Inventory) for assessment of six behavioral characteristics (Sense of Responsibility, Energy and Competitiveness, Obsessive Behavior, Anger and Hostility, Stress-related Disturbances, Time Urgency) was developed by using factor analysis on intercorrelations of responses from 524 subjects of the general population. Internal consistency reliability for each of the PSY subscales was estimated by Cronbach alpha coefficients. In a second step, the PSY Inventory was administered with the Cattell 16 PF Questionnaire to 838 patients affected by acute myocardial infarction. Significant correlations although relatively low in magnitude for PSY Inventory subscales and certain scales of the Cattell 16 PF were found. With factor analysis on 22 variables (including the six PSY Inventory subscales and the 16 scales of the Cattell 16 PF), five second-order factors were identified, namely, Extra-version, Neurotic Anxiety, Superego Strength, Pathemia, and Neurotic Hostility. While a Pathemia Factor (characterized by sensitivity, imagination, and self-sufficiency) was factorially independent of scales of the PSY Inventory, Extraversion, Neurotic Anxiety, Superego Strength, and Neurotic Hostility Factors were composed of the PSY Inventory scales and Cattell 16 PF scales combined. These relationships would reflect the concordance of internal constructs for behavioral measures of the PSY Inventory and those of personality traits of the 16 PF Questionnaire in patients with acute myocardial infarction.

Published
1996

45. Subsequent Event Risk in Individuals With Established Coronary Heart Disease : Design and Rationale of the GENIUS-CHD Consortium

Author

Patel, Riyaz S., Tragante, Vinicius, Schmidt, Amand F., McCubrey, Raymond O., Holmes, Michael, V, Howe, Laurence J., Direk, Kenan, Åkerblom, Axel, Leander, Karin, Virani, Salim S., Kaminski, Karol A., Muehlschlegel, Jochen D., Allayee, Hooman, Almgren, Peter, Alver, Maris, Baranova, Ekaterina, V, Behloui, Hassan, Boeckx, Bram, Braund, Peter S., Breitling, Lutz P., Delgado, Gradela, Duarte, Nubia E., Dube, Marie-Pierre, Dufresne, Line, Eriksson, Niclas, Foco, Luisa, Scholz, Markus, Gijsberts, Crystel M., Glinge, Charlotte, Gong, Yan, Hartiala, Jaana, Heydarpour, Mahyar, Hubacek, Jaroslav A., Kleber, Marcus, Kofink, Daniel, Kotti, Salma, Kuukasjarvi, Pekka, Lee, Vei-Vei, Leiherer, Andreas, Lenzini, Petra A., Levin, Daniel, Lyytikainen, Leo-Pekka, Martinelli, Nicola, Mons, Ute, Nelson, Christopher P., Nikus, Kjell, Pilbrow, Anna P., Ploski, Rafal, Sun, Yan, V, Tanck, Michael W. T., Tang, W. H. Wilson, Trompet, Stella, van der Laan, Sander W., Van Setten, Jessica, Vilmundarson, Ragnar O., Anselmi, Chiara Viviani, Vlachopoulou, Efthymia, Al Ali, Lawien, Boerwinkle, Eric, Briguori, Carlo, Carlquist, John F., Carruthers, Kathryn F., Casu, Gavino, Deanfield, John, Deloukas, Panos, Dudbridge, Frank, Engstrom, Thomas, Fitzpatrick, Natalie, Fox, Kim, Gigante, Bruna, James, Stefan, Lokki, Marja-Liisa, Lotufo, Paulo A., Marziliano, Nicola, Mordi, Ify R., Muhlestein, Joseph B., Newton-Cheh, Christopher, Pitha, Jan, Saely, Christoph H., Samman-Tahhan, Ayman, Sandesara, Pratik B., Teren, Andrej, Timmis, Adam, Van de Werf, Frans, Wauters, Els, Wilde, Arthur A. M., Ford, Ian, Stott, David J., Algra, Ale, Andreassi, Maria G., Ardissino, Diego, Arsenault, Benoit J., Ballantyne, Christie M., Bergmeijer, Thomas O., Bezzina, Connie R., Body, Simon C., Boersma, Eric H., Bogaty, Peter, Bots, Michiel L., Brenner, Hermann, Brugts, Jasper J., Burkhardt, Ralph, Carpeggiani, Clara, Condorelli, Gianluigi, Cooper-DeHoff, Rhonda M., Cresci, Sharon, Danchin, Nicolas, de Faire, Ulf, Doughty, Robert N., Drexel, Heinz, Engert, James C., Fox, Keith A. A., Girelli, Domenico, Grobbee, Diederick E., Hagström, Emil, Hazen, Stanley L., Held, Claes, Hemingway, Harry, Hoefer, Imo E., Hovingh, G. Kees, Jabbari, Reza, Johnson, Julie A., Jukema, J. Wouter, Kaczor, Marcin P., Kahonen, Mika, Kettner, Jiri, Kiliszek, Marek, Klungel, Olaf H., Lagerqvist, Bo, Lambrechts, Diether, Laurikka, Jari O., Lehtimaki, Terho, Lindholm, Daniel, Mahmoodi, B. K., Maitland-van der Zee, Anke H., McPherson, Ruth, Melander, Olle, Metspalu, Andres, Niemcunowicz-Janica, Anna, Olivieri, Oliviero, Opolski, Grzegorz, Palmer, Colin N., Pasterkamp, Gerard, Pepine, Carl J., Pereira, Alexandre C., Pilote, Louise, Quyyumi, Arshed A., Richards, A. Mark, Sanak, Marek, Siegbahn, Agneta, Simon, Tabassome, Sinisalo, Juha, Smith, J. Gustav, Spertus, John A., Stender, Steen, Stewart, Alexandre F. R., Szczeklik, Wojciech, Szpakowicz, Anna, Tardif, Jean-Claude, ten Berg, Jurrien M., Tfelt-Hansen, Jacob, Thanassoulis, George, Thiery, Joachim, Torp-Pedersen, Christian, van der Graaf, Yolanda, Visseren, Frank L. J., Waltenberger, Johannes, Weeke, Peter E., Van der Harst, Pim, Lang, Chim C., Sattar, Naveed, Cameron, Vicky A., Anderson, Jeffrey L., Brophy, James M., Pare, Guillaume, Horne, Benjamin D., Marz, Winfried, Wallentin, Lars, Samani, Nilesh J., Hingorani, Aroon D., Asselbergs, Folkert W., Patel, Riyaz S., Tragante, Vinicius, Schmidt, Amand F., McCubrey, Raymond O., Holmes, Michael, V, Howe, Laurence J., Direk, Kenan, Åkerblom, Axel, Leander, Karin, Virani, Salim S., Kaminski, Karol A., Muehlschlegel, Jochen D., Allayee, Hooman, Almgren, Peter, Alver, Maris, Baranova, Ekaterina, V, Behloui, Hassan, Boeckx, Bram, Braund, Peter S., Breitling, Lutz P., Delgado, Gradela, Duarte, Nubia E., Dube, Marie-Pierre, Dufresne, Line, Eriksson, Niclas, Foco, Luisa, Scholz, Markus, Gijsberts, Crystel M., Glinge, Charlotte, Gong, Yan, Hartiala, Jaana, Heydarpour, Mahyar, Hubacek, Jaroslav A., Kleber, Marcus, Kofink, Daniel, Kotti, Salma, Kuukasjarvi, Pekka, Lee, Vei-Vei, Leiherer, Andreas, Lenzini, Petra A., Levin, Daniel, Lyytikainen, Leo-Pekka, Martinelli, Nicola, Mons, Ute, Nelson, Christopher P., Nikus, Kjell, Pilbrow, Anna P., Ploski, Rafal, Sun, Yan, V, Tanck, Michael W. T., Tang, W. H. Wilson, Trompet, Stella, van der Laan, Sander W., Van Setten, Jessica, Vilmundarson, Ragnar O., Anselmi, Chiara Viviani, Vlachopoulou, Efthymia, Al Ali, Lawien, Boerwinkle, Eric, Briguori, Carlo, Carlquist, John F., Carruthers, Kathryn F., Casu, Gavino, Deanfield, John, Deloukas, Panos, Dudbridge, Frank, Engstrom, Thomas, Fitzpatrick, Natalie, Fox, Kim, Gigante, Bruna, James, Stefan, Lokki, Marja-Liisa, Lotufo, Paulo A., Marziliano, Nicola, Mordi, Ify R., Muhlestein, Joseph B., Newton-Cheh, Christopher, Pitha, Jan, Saely, Christoph H., Samman-Tahhan, Ayman, Sandesara, Pratik B., Teren, Andrej, Timmis, Adam, Van de Werf, Frans, Wauters, Els, Wilde, Arthur A. M., Ford, Ian, Stott, David J., Algra, Ale, Andreassi, Maria G., Ardissino, Diego, Arsenault, Benoit J., Ballantyne, Christie M., Bergmeijer, Thomas O., Bezzina, Connie R., Body, Simon C., Boersma, Eric H., Bogaty, Peter, Bots, Michiel L., Brenner, Hermann, Brugts, Jasper J., Burkhardt, Ralph, Carpeggiani, Clara, Condorelli, Gianluigi, Cooper-DeHoff, Rhonda M., Cresci, Sharon, Danchin, Nicolas, de Faire, Ulf, Doughty, Robert N., Drexel, Heinz, Engert, James C., Fox, Keith A. A., Girelli, Domenico, Grobbee, Diederick E., Hagström, Emil, Hazen, Stanley L., Held, Claes, Hemingway, Harry, Hoefer, Imo E., Hovingh, G. Kees, Jabbari, Reza, Johnson, Julie A., Jukema, J. Wouter, Kaczor, Marcin P., Kahonen, Mika, Kettner, Jiri, Kiliszek, Marek, Klungel, Olaf H., Lagerqvist, Bo, Lambrechts, Diether, Laurikka, Jari O., Lehtimaki, Terho, Lindholm, Daniel, Mahmoodi, B. K., Maitland-van der Zee, Anke H., McPherson, Ruth, Melander, Olle, Metspalu, Andres, Niemcunowicz-Janica, Anna, Olivieri, Oliviero, Opolski, Grzegorz, Palmer, Colin N., Pasterkamp, Gerard, Pepine, Carl J., Pereira, Alexandre C., Pilote, Louise, Quyyumi, Arshed A., Richards, A. Mark, Sanak, Marek, Siegbahn, Agneta, Simon, Tabassome, Sinisalo, Juha, Smith, J. Gustav, Spertus, John A., Stender, Steen, Stewart, Alexandre F. R., Szczeklik, Wojciech, Szpakowicz, Anna, Tardif, Jean-Claude, ten Berg, Jurrien M., Tfelt-Hansen, Jacob, Thanassoulis, George, Thiery, Joachim, Torp-Pedersen, Christian, van der Graaf, Yolanda, Visseren, Frank L. J., Waltenberger, Johannes, Weeke, Peter E., Van der Harst, Pim, Lang, Chim C., Sattar, Naveed, Cameron, Vicky A., Anderson, Jeffrey L., Brophy, James M., Pare, Guillaume, Horne, Benjamin D., Marz, Winfried, Wallentin, Lars, Samani, Nilesh J., Hingorani, Aroon D., and Asselbergs, Folkert W.

Abstract

BACKGROUND: The Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD. METHODS: The consortium currently includes 57 studies from 18 countries, recruiting 185 614 participants with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events. RESULTS: Enrollment into the individual studies took place between 1985 to present day with a duration of follow-up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%-100%), mostly male (44%-91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (hazard ratio, 1.15; 95% CI, 1.14-1.16) per 5-year increase, male sex (hazard ratio, 1.17; 95% CI, 1.13-1.21) and smoking (hazard ratio, 1.43; 95% CI, 1.35-1.51) with risk of subsequent CHD death or myocardial infarction and differing associations with other individual and composite cardiovascular endpoints. CONCLUSIONS: GENIUS-CHD is a global collaboration seeking to elucidate genetic and nongenetic determinants of subsequent event risk in individuals with established CHD, to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators.

Published
2019
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46. Software integral de eco estrés para protocolo ABDCE de última generación

Author

Paterni, Marco, Carpeggiani, Clara, Ciampi, Quirino, Citro, Rodolfo, Antonini Canterin, Francesco, Colonna, Paolo, Picano, Eugenio, Paterni, Marco, Carpeggiani, Clara, Ciampi, Quirino, Citro, Rodolfo, Antonini Canterin, Francesco, Colonna, Paolo, and Picano, Eugenio

Abstract

Background: Several specialized softwares are commercially available for the elective storage of stress echo (SE) data. State-of-theart SE is based upon novel parameters in addition to regional wall motion. Objective: To develop a novel software for SE data storage and reporting. Methods: We developed the prototype of a SE Comprehensive Software (SECS) with a minimum data set eventually allowing standardized collection of data. The software runs with medium-low performance computers as well as with the most popular operating systems (Windows, MAC OS and Linux). The export functions towards widely accepted formats allow easy data sharing. The software is able to generate a customized report which can be expanded in PDF and comma-separated values formats. Results: The program prototype data entry requires < 2 min per study. The main pages focus on the 5 steps of ABCDE-SE: step A (regional wall motion); step B (B-lines with 4-site simplified scan); step C (contractile reserve with force derived from systolic blood pressure and end-systolic volume); step D (Doppler-based coronary flow velocity reserve in left anterior descending coronary artery); step E (EKG-based chronotropic reserve measured as peak/rest heart rate). The final page graphically summarizes the ABCDE information in a risk prediction model (cardiac death rate per year, from low risk < 1% to high risk > 3 %). Conclusion: SECS may provide a suitable infrastructure for an advanced clinical and research application, with simple graphic format and convenient reporting option. It may represent a trade-off between exhaustive information required by scientific standards and smooth workflow priority of busy, high volume, clinically-driven activities. Large scale validation and adaptation from users’ feedback is necessary prior to dissemination on demand., Introducción: Existen diversos softwares especializados en el mercado para el almacenamiento electivo de datos de eco estrés (EE). El EE de última generación incorpora nuevos parámetros además de la motilidad parietal. Objetivo: Desarrollar un nuevo software para el almacenamiento de datos e informe de EE. Métodos: Desarrollamos el prototipo de Software Integral de EE (SIEE) con un conjunto mínimo de datos que permite la eventual recolección estandarizada de datos. El software corre en computadoras con capacidad de trabajo mediana-baja y con los sistemas operativos más usados (Windows, MAC OS y Linux). Las funciones de exportación hacia formatos altamente aceptados permiten compartir los datos fácilmente. El software es capaz de generar un informe personalizado que se puede expandir en PDF y en formatos de valores separados por comas. Resultados: El ingreso de datos en el programa prototipo requiere menos de 2 minutos por estudio. Las páginas principales se concentran en las 5 fases ABCDE del EE: fase A (motilidad parietal regional); fase B (líneas B con escaneo simplificado de 4 sitios); fase C (reserva contráctil con fuerza derivada de la presión arterial sistólica y volumen de fin de sístole; fase D (Doppler de reserva coronaria de la arteria descendente anterior); y fase E (reserva cronotrópica derivada del electrocardiograma medida como la razón de frecuencia cardíaca pico/reposo). La última página resume la información ABCDE en un modelo de predicción de riesgo (tasa de muerte cardiovascular anual, abarcando desde riesgo bajo <1% hasta riego alto >3%. Conclusión: El SIEE puede proporcionar una infraestructura adecuada para una aplicación clínica y de investigación avanzada, con un formato gráfico simple y opción de informe satisfactoria. Puede representar una solución intermedia entre la información exhaustiva requerida por los estándares científicos y la prioridad de un flujo de trabajo fluido de actividades relacionadas a la clínica con gran volumen de pacie

Published
2019

47. Subsequent Event Risk in Individuals with Established Coronary Heart Disease: Design and Rationale of the GENIUS-CHD Consortium

Author

Onderzoek Precision medicine, Circulatory Health, UMC Utrecht, Aios en Stafsecr. Cardiologie, Experimentele Afd. Cardiologie 1, Apotheek Klinische Farmacie Kinderen, CDL Onderzoek Pasterkamp, Cardiovasculaire Epi Team 6, ZL Cerebrovasculaire Ziekten Medisch, Brain, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 5, Cardiovasculaire Epi Team 9, CDL Arcadia, Global Health, JC onderzoeksprogramma Methodologie, dLAB Afdelingen, Device, Interne Geneeskunde Vasculaire, Team Medisch, Patel, Riyaz S., Tragante, Vinicius, Schmidt, Amand F., McCubrey, Raymond O., Holmes, Michael V., Howe, Laurence J., Direk, Kenan, Åkerblom, Axel, Leander, Karin, Virani, Salim S., Kaminski, Karol A., Muehlschlegel, Jochen D., Allayee, Hooman, Almgren, Peter, Alver, Maris, Baranova, Ekaterina V., Behloui, Hassan, Boeckx, Bram, Braund, Peter S., Breitling, Lutz P., Delgado, Graciela, Duarte, Nubia E., Dubé, Marie Pierre, Dufresne, Line, Eriksson, Niclas, Foco, Luisa, Scholz, Markus, Gijsberts, Crystel M., Glinge, Charlotte, Gong, Yan, Hartiala, Jaana, Heydarpour, Mahyar, Hubacek, Jaroslav A., Kleber, Marcus, Kofink, Daniel, Kotti, Salma, Kuukasjärvi, Pekka, Lee, Vei Vei, Leiherer, Andreas, Lenzini, Petra A., Levin, Daniel, Lyytikäinen, Leo Pekka, Martinelli, Nicola, Mons, Ute, Nelson, Christopher P., Nikus, Kjell, Pilbrow, Anna P., Ploski, Rafal, Sun, Yan V., Tanck, Michael W.T., Tang, W. H.Wilson, Trompet, Stella, van der Laan, Sander W., Van Setten, Jessica, Vilmundarson, Ragnar O., Viviani Anselmi, Chiara, Vlachopoulou, Efthymia, Al Ali, Lawien, Boerwinkle, Eric, Briguori, Carlo, Carlquist, John F., Carruthers, Kathryn F., Casu, Gavino, Deanfield, John, Deloukas, Panos, Dudbridge, Frank, Engstrøm, Thomas, Fitzpatrick, Natalie, Fox, Kim, Gigante, Bruna, James, Stefan, Lokki, Marja Liisa, Lotufo, Paulo A., Marziliano, Nicola, Mordi, Ify R., Muhlestein, Joseph B., Newton-Cheh, Christopher, Pitha, Jan, Saely, Christoph H., Samman-Tahhan, Ayman, Sandesara, Pratik B., Teren, Andrej, Timmis, Adam, Van de Werf, Frans, Wauters, Els, Wilde, Arthur A.M., Ford, Ian, Stott, David J., Algra, Ale, Andreassi, Maria G., Ardissino, Diego, Arsenault, Benoit J., Ballantyne, Christie M., Bergmeijer, Thomas O., Bezzina, Connie R., Body, Simon C., Boersma, Eric H., Bogaty, Peter, Bots, Michiel L., Brenner, Hermann, Brugts, Jasper J., Burkhardt, Ralph, Carpeggiani, Clara, Condorelli, Gianluigi, Cooper-DeHoff, Rhonda M., Cresci, Sharon, Danchin, Nicolas, de Faire, Ulf, Doughty, Robert N., Drexel, Heinz, Engert, James C., Fox, Keith A.A., Girelli, Domenico, Grobbee, Diederick E., Hagström, Emil, Hazen, Stanley L., Held, Claes, Hemingway, Harry, Hoefer, Imo E., Hovingh, G. Kees, Jabbari, Reza, Johnson, Julie A., Jukema, J. Wouter, Kaczor, Marcin P., Kähönen, Mika, Kettner, Jiri, Kiliszek, Marek, Klungel, Olaf H., Lagerqvist, Bo, Lambrechts, Diether, Laurikka, Jari O., Lehtimäki, Terho, Lindholm, Daniel, Mahmoodi, B. K., Maitland-van der Zee, Anke H., McPherson, Ruth, Melander, Olle, Metspalu, Andres, Niemcunowicz-Janica, Anna, Olivieri, Oliviero, Opolski, Grzegorz, Palmer, Colin N., Pasterkamp, Gerard, Pepine, Carl J., Pereira, Alexandre C., Pilote, Louise, Quyyumi, Arshed A., Richards, A. Mark, Sanak, Marek, Siegbahn, Agneta, Simon, Tabassome, Sinisalo, Juha, Smith, J. Gustav, Spertus, John A., Stender, Steen, Stewart, Alexandre F.R., Szczeklik, Wojciech, Szpakowicz, Anna, Tardif, Jean Claude, Ten Berg, Jurriën M., Tfelt-Hansen, Jacob, Thanassoulis, George, Thiery, Joachim, Torp-Pedersen, Christian, van der Graaf, Yolanda, Visseren, Frank L.J., Waltenberger, Johannes, Weeke, Peter E., Van der Harst, Pim, Lang, Chim C., Sattar, Naveed, Cameron, Vicky A., Anderson, Jeffrey L., Brophy, James M., Pare, Guillaume, Horne, Benjamin D., März, Winfried, Wallentin, Lars, Samani, Nilesh J., Hingorani, Aroon D., Asselbergs, Folkert W., Onderzoek Precision medicine, Circulatory Health, UMC Utrecht, Aios en Stafsecr. Cardiologie, Experimentele Afd. Cardiologie 1, Apotheek Klinische Farmacie Kinderen, CDL Onderzoek Pasterkamp, Cardiovasculaire Epi Team 6, ZL Cerebrovasculaire Ziekten Medisch, Brain, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 5, Cardiovasculaire Epi Team 9, CDL Arcadia, Global Health, JC onderzoeksprogramma Methodologie, dLAB Afdelingen, Device, Interne Geneeskunde Vasculaire, Team Medisch, Patel, Riyaz S., Tragante, Vinicius, Schmidt, Amand F., McCubrey, Raymond O., Holmes, Michael V., Howe, Laurence J., Direk, Kenan, Åkerblom, Axel, Leander, Karin, Virani, Salim S., Kaminski, Karol A., Muehlschlegel, Jochen D., Allayee, Hooman, Almgren, Peter, Alver, Maris, Baranova, Ekaterina V., Behloui, Hassan, Boeckx, Bram, Braund, Peter S., Breitling, Lutz P., Delgado, Graciela, Duarte, Nubia E., Dubé, Marie Pierre, Dufresne, Line, Eriksson, Niclas, Foco, Luisa, Scholz, Markus, Gijsberts, Crystel M., Glinge, Charlotte, Gong, Yan, Hartiala, Jaana, Heydarpour, Mahyar, Hubacek, Jaroslav A., Kleber, Marcus, Kofink, Daniel, Kotti, Salma, Kuukasjärvi, Pekka, Lee, Vei Vei, Leiherer, Andreas, Lenzini, Petra A., Levin, Daniel, Lyytikäinen, Leo Pekka, Martinelli, Nicola, Mons, Ute, Nelson, Christopher P., Nikus, Kjell, Pilbrow, Anna P., Ploski, Rafal, Sun, Yan V., Tanck, Michael W.T., Tang, W. H.Wilson, Trompet, Stella, van der Laan, Sander W., Van Setten, Jessica, Vilmundarson, Ragnar O., Viviani Anselmi, Chiara, Vlachopoulou, Efthymia, Al Ali, Lawien, Boerwinkle, Eric, Briguori, Carlo, Carlquist, John F., Carruthers, Kathryn F., Casu, Gavino, Deanfield, John, Deloukas, Panos, Dudbridge, Frank, Engstrøm, Thomas, Fitzpatrick, Natalie, Fox, Kim, Gigante, Bruna, James, Stefan, Lokki, Marja Liisa, Lotufo, Paulo A., Marziliano, Nicola, Mordi, Ify R., Muhlestein, Joseph B., Newton-Cheh, Christopher, Pitha, Jan, Saely, Christoph H., Samman-Tahhan, Ayman, Sandesara, Pratik B., Teren, Andrej, Timmis, Adam, Van de Werf, Frans, Wauters, Els, Wilde, Arthur A.M., Ford, Ian, Stott, David J., Algra, Ale, Andreassi, Maria G., Ardissino, Diego, Arsenault, Benoit J., Ballantyne, Christie M., Bergmeijer, Thomas O., Bezzina, Connie R., Body, Simon C., Boersma, Eric H., Bogaty, Peter, Bots, Michiel L., Brenner, Hermann, Brugts, Jasper J., Burkhardt, Ralph, Carpeggiani, Clara, Condorelli, Gianluigi, Cooper-DeHoff, Rhonda M., Cresci, Sharon, Danchin, Nicolas, de Faire, Ulf, Doughty, Robert N., Drexel, Heinz, Engert, James C., Fox, Keith A.A., Girelli, Domenico, Grobbee, Diederick E., Hagström, Emil, Hazen, Stanley L., Held, Claes, Hemingway, Harry, Hoefer, Imo E., Hovingh, G. Kees, Jabbari, Reza, Johnson, Julie A., Jukema, J. Wouter, Kaczor, Marcin P., Kähönen, Mika, Kettner, Jiri, Kiliszek, Marek, Klungel, Olaf H., Lagerqvist, Bo, Lambrechts, Diether, Laurikka, Jari O., Lehtimäki, Terho, Lindholm, Daniel, Mahmoodi, B. K., Maitland-van der Zee, Anke H., McPherson, Ruth, Melander, Olle, Metspalu, Andres, Niemcunowicz-Janica, Anna, Olivieri, Oliviero, Opolski, Grzegorz, Palmer, Colin N., Pasterkamp, Gerard, Pepine, Carl J., Pereira, Alexandre C., Pilote, Louise, Quyyumi, Arshed A., Richards, A. Mark, Sanak, Marek, Siegbahn, Agneta, Simon, Tabassome, Sinisalo, Juha, Smith, J. Gustav, Spertus, John A., Stender, Steen, Stewart, Alexandre F.R., Szczeklik, Wojciech, Szpakowicz, Anna, Tardif, Jean Claude, Ten Berg, Jurriën M., Tfelt-Hansen, Jacob, Thanassoulis, George, Thiery, Joachim, Torp-Pedersen, Christian, van der Graaf, Yolanda, Visseren, Frank L.J., Waltenberger, Johannes, Weeke, Peter E., Van der Harst, Pim, Lang, Chim C., Sattar, Naveed, Cameron, Vicky A., Anderson, Jeffrey L., Brophy, James M., Pare, Guillaume, Horne, Benjamin D., März, Winfried, Wallentin, Lars, Samani, Nilesh J., Hingorani, Aroon D., and Asselbergs, Folkert W.

Published
2019

48. Subsequent Event Risk in Individuals with Established Coronary Heart Disease:Design and Rationale of the GENIUS-CHD Consortium

Author

Patel, Riyaz, Tragante, Vinicius, Schmidt, Amand F, McCubrey, Raymond O, Holmes, Michael V, Howe, Laurence J, Direk, Kenan, Åkerblom, Axel, Leander, Karin, Virani, Salim S, Kaminski, Karol A, Muehlschlegel, Jochen D, Allayee, Hooman, Almgren, Peter, Alver, Maris, Baranova, Ekaterina V, Behlouli, Hassan, Boeckx, Bram, Braund, Peter S, Breitling, Lutz P, Delgado, Graciela, Duarte, Nubia E, Dubé, Marie-Pierre, Dufresne, Line, Eriksson, Niclas, Foco, Luisa, Scholz, Markus, Gijsberts, Crystel M, Glinge, Charlotte, Gong, Yan, Hartiala, Jaana, Heydarpour, Mahyar, Hubacek, Jaroslav A, Kleber, Marcus, Kofink, Daniel, Kotti, Salma, Kuukasjärvi, Pekka, Lee, Vei-Vei, Leiherer, Andreas, Lenzini, Petra A, Levin, Daniel, Lyytikäinen, Leo-Pekka, Martinelli, Nicola, Mons, Ute, Nelson, Christopher P, Nikus, Kjell, Pilbrow, Anna P, Ploski, Rafal, Sun, Yan V, Tanck, Michael W T, Tang, W H Wilson, Trompet, Stella, van der Laan, Sander W, Van Setten, Jessica, Vilmundarson, Ragnar O, Viviani Anselmi, Chiara, Vlachopoulou, Efthymia, Al Ali, Lawien, Boerwinkle, Eric, Briguori, Carlo, Carlquist, John F, Carruthers, Kathryn F, Casu, Gavino, Deanfield, John, Deloukas, Panos, Dudbridge, Frank, Engström, Thomas, Fitzpatrick, Natalie, Fox, Kim, Gigante, Bruna, James, Stefan, Lokki, Marja-Liisa, Lotufo, Paulo A, Marziliano, Nicola, Mordi, Ify R, Muhlestein, Joseph B, Newton-Cheh, Christopher, Pitha, Jan, Saely, Christoph H, Samman-Tahhan, Ayman, Sandesara, Pratik B, Teren, Andrej, Timmis, Adam, Van de Werf, Frans, Wauters, Els, Wilde, Arthur A M, Ford, Ian, Stott, David J, Algra, Ale, Andreassi, Maria G, Ardissino, Diego, Arsenault, Benoit J, Ballantyne, Christie M, Bergmeijer, Thomas O, Bezzina, Connie R, Body, Simon C, Boersma, Eric H, Bogaty, Peter, Bots, Michiel, Brenner, Hermann, Brugts, Jasper J, Burkhardt, Ralph, Carpeggiani, Clara, Condorelli, Gianluigi, Cooper-DeHoff, Rhonda M, Cresci, Sharon, Danchin, Nicolas, de Faire, Ulf, Doughty, Robert N, Drexel, Heinz, Engert, James C, Fox, Keith A A, Girelli, Domenico, Grobbee, Diederick E, Hagström, Emil, Hazen, Stanley L, Held, Claes, Hemingway, Harry, Hoefer, Imo E, Hovingh, G Kees, Jabbari, Reza, Johnson, Julie A, Jukema, J Wouter, Kaczor, Marcin P, Kähönen, Mika, Kettner, Jiri, Kiliszek, Marek, Klungel, Olaf H, Lagerqvist, Bo, Lambrechts, Diether, Laurikka, Jari O, Lehtimäki, Terho, Lindholm, Daniel, Mahmoodi, B K, Maitland-van der Zee, Anke H, McPherson, Ruth, Melander, Olle, Metspalu, Andres, Niemcunowicz-Janica, Anna, Olivieri, Oliviero, Opolski, Grzegorz, Palmer, Colin N, Pasterkamp, Gerard, Pepine, Carl J, Pereira, Alexandre C, Pilote, Louise, Quyyumi, Arshed A, Richards, A Mark, Sanak, Marek, Siegbahn, Agneta, Simon, Tabassome, Sinisalo, Juha, Smith, J Gustav, Spertus, John A, Stender, Steen, Stewart, Alexandre F R, Szczeklik, Wojciech, Szpakowicz, Anna, Tardif, Jean-Claude, Ten Berg, Jurriën M, Tfelt-Hansen, Jacob, Thanassoulis, George, Thiery, Joachim, Torp-Pedersen, Christian, van der Graaf, Yolanda, Visseren, Frank L J, Waltenberger, Johannes, Weeke, Peter E, Van der Harst, Pim, Lang, Chim C, Sattar, Naveed, Cameron, Vicky A, Anderson, Jeffrey L, Brophy, James M, Paré, Guillaume, Horne, Benjamin D, März, Winfried, Wallentin, Lars, Samani, Nilesh J, Hingorani, Aroon D, Asselbergs, Folkert W, Patel, Riyaz, Tragante, Vinicius, Schmidt, Amand F, McCubrey, Raymond O, Holmes, Michael V, Howe, Laurence J, Direk, Kenan, Åkerblom, Axel, Leander, Karin, Virani, Salim S, Kaminski, Karol A, Muehlschlegel, Jochen D, Allayee, Hooman, Almgren, Peter, Alver, Maris, Baranova, Ekaterina V, Behlouli, Hassan, Boeckx, Bram, Braund, Peter S, Breitling, Lutz P, Delgado, Graciela, Duarte, Nubia E, Dubé, Marie-Pierre, Dufresne, Line, Eriksson, Niclas, Foco, Luisa, Scholz, Markus, Gijsberts, Crystel M, Glinge, Charlotte, Gong, Yan, Hartiala, Jaana, Heydarpour, Mahyar, Hubacek, Jaroslav A, Kleber, Marcus, Kofink, Daniel, Kotti, Salma, Kuukasjärvi, Pekka, Lee, Vei-Vei, Leiherer, Andreas, Lenzini, Petra A, Levin, Daniel, Lyytikäinen, Leo-Pekka, Martinelli, Nicola, Mons, Ute, Nelson, Christopher P, Nikus, Kjell, Pilbrow, Anna P, Ploski, Rafal, Sun, Yan V, Tanck, Michael W T, Tang, W H Wilson, Trompet, Stella, van der Laan, Sander W, Van Setten, Jessica, Vilmundarson, Ragnar O, Viviani Anselmi, Chiara, Vlachopoulou, Efthymia, Al Ali, Lawien, Boerwinkle, Eric, Briguori, Carlo, Carlquist, John F, Carruthers, Kathryn F, Casu, Gavino, Deanfield, John, Deloukas, Panos, Dudbridge, Frank, Engström, Thomas, Fitzpatrick, Natalie, Fox, Kim, Gigante, Bruna, James, Stefan, Lokki, Marja-Liisa, Lotufo, Paulo A, Marziliano, Nicola, Mordi, Ify R, Muhlestein, Joseph B, Newton-Cheh, Christopher, Pitha, Jan, Saely, Christoph H, Samman-Tahhan, Ayman, Sandesara, Pratik B, Teren, Andrej, Timmis, Adam, Van de Werf, Frans, Wauters, Els, Wilde, Arthur A M, Ford, Ian, Stott, David J, Algra, Ale, Andreassi, Maria G, Ardissino, Diego, Arsenault, Benoit J, Ballantyne, Christie M, Bergmeijer, Thomas O, Bezzina, Connie R, Body, Simon C, Boersma, Eric H, Bogaty, Peter, Bots, Michiel, Brenner, Hermann, Brugts, Jasper J, Burkhardt, Ralph, Carpeggiani, Clara, Condorelli, Gianluigi, Cooper-DeHoff, Rhonda M, Cresci, Sharon, Danchin, Nicolas, de Faire, Ulf, Doughty, Robert N, Drexel, Heinz, Engert, James C, Fox, Keith A A, Girelli, Domenico, Grobbee, Diederick E, Hagström, Emil, Hazen, Stanley L, Held, Claes, Hemingway, Harry, Hoefer, Imo E, Hovingh, G Kees, Jabbari, Reza, Johnson, Julie A, Jukema, J Wouter, Kaczor, Marcin P, Kähönen, Mika, Kettner, Jiri, Kiliszek, Marek, Klungel, Olaf H, Lagerqvist, Bo, Lambrechts, Diether, Laurikka, Jari O, Lehtimäki, Terho, Lindholm, Daniel, Mahmoodi, B K, Maitland-van der Zee, Anke H, McPherson, Ruth, Melander, Olle, Metspalu, Andres, Niemcunowicz-Janica, Anna, Olivieri, Oliviero, Opolski, Grzegorz, Palmer, Colin N, Pasterkamp, Gerard, Pepine, Carl J, Pereira, Alexandre C, Pilote, Louise, Quyyumi, Arshed A, Richards, A Mark, Sanak, Marek, Siegbahn, Agneta, Simon, Tabassome, Sinisalo, Juha, Smith, J Gustav, Spertus, John A, Stender, Steen, Stewart, Alexandre F R, Szczeklik, Wojciech, Szpakowicz, Anna, Tardif, Jean-Claude, Ten Berg, Jurriën M, Tfelt-Hansen, Jacob, Thanassoulis, George, Thiery, Joachim, Torp-Pedersen, Christian, van der Graaf, Yolanda, Visseren, Frank L J, Waltenberger, Johannes, Weeke, Peter E, Van der Harst, Pim, Lang, Chim C, Sattar, Naveed, Cameron, Vicky A, Anderson, Jeffrey L, Brophy, James M, Paré, Guillaume, Horne, Benjamin D, März, Winfried, Wallentin, Lars, Samani, Nilesh J, Hingorani, Aroon D, and Asselbergs, Folkert W

Abstract

BACKGROUND: The "GENetIcs of sUbSequent Coronary Heart Disease" (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD.METHODS: The consortium currently includes 57 studies from 18 countries, recruiting 185,614 participants with either acute coronary syndrome, stable CHD or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events.RESULTS: Enrollment into the individual studies took place between 1985 to present day with duration of follow up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%-100%), mostly male (44%-91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (HR 1.15 95% CI 1.14-1.16) per 5-year increase, male sex (HR 1.17, 95% CI 1.13-1.21) and smoking (HR 1.43, 95% CI 1.35-1.51) with risk of subsequent CHD death or myocardial infarction, and differing associations with other individual and composite cardiovascular endpoints.CONCLUSIONS: GENIUS-CHD is a global collaboration seeking to elucidate genetic and non-genetic determinants of subsequent event risk in individuals with established CHD, in order to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators.

Published
2019

50. The second-order factor structure of Cattell's 16 PF in patients with coronary heart disease

Author

Bonaguidi, Franco, Trivella, M. Giovanna, Michelassi, Claudio, Carpeggiani, Clara, and L'Abbate, Antonio

Subjects
Sixteen personality factor questionnaire -- Evaluation, Cardiac patients -- Psychological aspects, Psychology and mental health
Abstract

The second-order factor structure of the 16 Personality Factor Questionnaire (16 PF) was validated on a sample of 940 patients hospitalized for coronary heart disease. The purpose of this investigation was the evaluation of second-order factor structure, already confirmed for normal subjects, of a selected pathological population. With factor analyses, oblique promax rotation, five second-order factors were identified, namely, Anxiety, Extraversion, Pathemia, Control, and an unidentified factor. These results were compared with those of Cattell's and Krug's studies. As a high congruence coefficient was shown, a good replication of Cattell's originally published second-order factors was achieved.

Published
1994

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