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1. OBEDIS Core Variables Project: European Expert Guidelines on a Minimal Core Set of Variables to Include in Randomized, Controlled Clinical Trials of Obesity Interventions

Author: António L. Palmeira, Thorkild I. A. Sørensen, Martin Neovius, Martine Laville, Mikael Rydén, Andrea Natali, Maud Alligier, Romain Barrès, Kristina Campbell, David Jacobi, I. Sadaf Farooqi, Jean-Michel Oppert, Helen M. Roche, André Scheen, Karine Clément, Ellen E. Blaak, Yves Boirie, Gijs H. Goossens, Jason C.G. Halford, Luc Tappy, Nathalie Farpour-Lambert, Hannele Yki-Järvinen, Uberto Pagotto, Chantal Simon, Jörg Hager, Jildau Bouwman, Paul Brunault, Gema Frühbeck, Dominique Langin, Olivier Ziegler, Chantal Julia, Hans Hauner, Centre de Recherche en Nutrition Humaine Rhône-Alpes (CRNH-RA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), University of Copenhagen = Københavns Universitet (KU), Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR), Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), Maastricht University Medical Centre (MUMC), Maastricht University [Maastricht], CHU Clermont-Ferrand, Netherlands Organization for Applied Scientific Research (TNO), TNO Science and Industry, Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Tours (UT), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), KC Microbiome Communications Group, Nutrition et obésités: approches systémiques (nutriomics) (UMR-S 1269 INSERM - Sorbonne Université), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), NIHR Biomedical Research Centre [London], Guy's and St Thomas' NHS Foundation Trust-King‘s College London, University of Cambridge [UK] (CAM), Université de Genève (UNIGE), Geneva University Hospitals and Geneva University, Clínica Universidad de Navarra [Pamplona], Nestlé Institute of Health Sciences SA [Lausanne, Switzerland], University of Liverpool, Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Klinikums rechts der Isar, Centre National de la Recherche Scientifique (CNRS), Université de Nantes (UN), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Sorbonne Paris Nord-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Pisa - Università di Pisa, Karolinska Institutet [Stockholm], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Alma Mater Studiorum University of Bologna (UNIBO), Université de Lisbonne, University College Dublin [Dublin] (UCD), Centre Hospitalier Universitaire de Liège (CHU-Liège), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Université de Lausanne (UNIL), Minerva Foundation Institute for Medical Research, University of Helsinki, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Joint Programming Initiative Heathy Diet for Healthy Life, Alligier M., Barres R., Blaak E.E., Boirie Y., Bouwman J., Brunault P., Campbell K., Clement K., Farooqi I.S., Farpour-Lambert N.J., Fruhbeck G., Goossens G.H., Hager J., Halford J.C.G., Hauner H., Jacobi D., Julia C., Langin D., Natali A., Neovius M., Oppert J.M., Pagotto U., Palmeira A.L., Roche H., Ryden M., Scheen A.J., Simon C., Sorensen T.I.A., Tappy L., Yki-Jarvinen H., Ziegler O., Laville M., FCRIN/FORCE Network, Centre de Recherche en Nutrition Humaine Rhône-Alpes, Novo Nordisk, Department of Human Biology, Maastricht University Medical Center (MUMC), Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Nutrition clinique, Centre Hospitalier Universitaire Gabriel Montpied, TNO,Netherlands Organisation for Applied Scientific Research, UMR U 1253, Université de Tours, Nutrition et obésité : approches systémiques, Sorbonne Université, Wellcome-MRC Institute of Metabolic Science and NIHR Biomedical Research Centre, University of Cambridge, Service of Therapeutic Education for Chronic Diseases, Department of Community Health, Primary Care and Emergency, Geneva University Hospitals, Department of Endocrinology and Nutrition, Navarra Public Health Institute, Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición - Biomedical Research Center in Red-Physiopathology of Obesity and Nutrition (CIBEROBN), University of Navarra, University of Cape Town, Metabolic Phenotyping, Nestlé Institute of Health Sciences, Psychological Sciences, University of Liverpool (University of Liverpool), Institut für Ernährungsmedizin des Klinikums Rechts der Isar, Technical University of Munich (TUM), Institut du Thorax, Centre Hospitalier Universitaire de Nantes, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC), Université Toulouse III - Paul Sabatier, Centre Hospitalier Universitaire de Toulouse, Department of Clinical and Experimental Medicine, Università degli studi di Napoli Federico II, Department of Medicine (Solna), Nutrition, Institut de Cardiométabolisme et Nutrition (ICAN), CHU Pitié-Salpêtrière [APHP], Department of Medical and Surgical Sciences, Universita degli Studi di Padova, CIPER, PANO-SR, Faculty of Human Kinetics, University of Lisbon, UCD Institute of Food and Health, University College Dublin (UCD), Department of Medicine, The University of Sydney, Diabètes, Nutrition et maladies métaboliques, Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Physiologie, Université de Picardie Jules Verne (UPJV), Helsinki University Central Hospital, Endocrinologie, Diabetes et Nutrition, Hôpital Brabois, Maastricht University [Maastricht]-Maastricht University [Maastricht], Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, ProdInra, Archive Ouverte, Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), University of Copenhagen = Københavns Universitet (UCPH), University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH), Nutrition et obésités: approches systémiques (UMR-S 1269) (Nutriomics), Université de Genève = University of Geneva (UNIGE), Unité de recherche de l'institut du thorax (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Lausanne = University of Lausanne (UNIL), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, HUS Internal Medicine and Rehabilitation, Humane Biologie, and RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health
Subjects: 0301 basic medicine, Research design, Gerontology, Health (social science), Psychological intervention, Choice Behavior, 0302 clinical medicine, QUALITY-OF-LIFE, OBSTRUCTIVE SLEEP-APNEA, Medicine, Medical History Taking, lcsh:RC620-627, Interventions, METABOLIC SYNDROME, Randomized Controlled Trials as Topic, ddc:616, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Precision medicine, Prognosis, C-REACTIVE PROTEIN, 3. Good health, Europe, lcsh:Nutritional diseases. Deficiency diseases, CARDIOVASCULAR-DISEASE, Research Design, Variable, lcsh:Nutrition. Foods and food supply, Human, Prognosi, education, WEIGHT-LOSS, lcsh:TX341-641, Intervention, 030209 endocrinology & metabolism, GASTRIC BYPASS-SURGERY, Guidelines, Patient care, 03 medical and health sciences, Variables, Physiology (medical), Humans, CORONARY-HEART-DISEASE, Obesity, Expert Testimony, Core set, 030109 nutrition & dietetics, business.industry, Stratification, medicine.disease, Diet, BODY-MASS INDEX, Clinical trial, PHYSICAL-ACTIVITY, Biological Variation, Population, 3121 General medicine, internal medicine and other clinical medicine, Metabolic syndrome, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Heterogeneity of interindividual and intraindividual responses to interventions is often observed in randomized, controlled trials for obesity. To address the global epidemic of obesity and move toward more personalized treatment regimens, the global research community must come together to identify factors that may drive these heterogeneous responses to interventions. This project, called OBEDIS (OBEsity Diverse Interventions Sharing - focusing on dietary and other interventions), provides a set of European guidelines for a minimal set of variables to include in future clinical trials on obesity, regardless of the specific endpoints. Broad adoption of these guidelines will enable researchers to harmonize and merge data from multiple intervention studies, allowing stratification of patients according to precise phenotyping criteria which are measured using standardized methods. In this way, studies across Europe may be pooled for better prediction of individuals' responses to an intervention for obesity - ultimately leading to better patient care and improved obesity outcomes. © 2020 The Author(s) Published by S. Karger AG, Basel.
Published: 2020

2. Risk assessment of using off‐label morphine sulfate in a population‐based retrospective cohort of opioid‐dependent patients

Author: Nicolas Authier, Denis Ardid, Jessica Delorme, Hélène Peyrière, Georges Brousse, Célian Bertin, Chouki Chenaf, Marie Riquelme, Alain Eschalier, Neuro-Dol (Neuro-Dol), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques er émergentes (TransVIHMI), Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Université Montpellier 1 (UM1), Faculté de Médecine - Clermont-Ferrand, Université d'Auvergne - Clermont-Ferrand I (UdA), Pharmacologie fondamentale et clinique de la douleur, Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Pôle de biologie médicale et d'anatomie pathologique, CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Neuro-Dol - Clermont Auvergne (Neuro-Dol), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA), Unité Mixte de Recherches sur les Herbivores - UMR 1213 (UMRH), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Recherche Agronomique (INRA), Recherches Translationnelles sur le VIH et les maladies infectieuses (TransVIHMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche pour le Développement (IRD)-Université Montpellier 1 (UM1)-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Universtié Yaoundé 1 [Cameroun]-Université de Montpellier (UM), Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire Gabriel Montpied, Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes (TransVIHMI), and Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)
Subjects: Male, medicine.medical_specialty, [SDV]Life Sciences [q-bio], Risk Assessment, 030226 pharmacology & pharmacy, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Opiate Substitution Treatment, medicine, Humans, Pharmacology (medical), 030212 general & internal medicine, ComputingMilieux_MISCELLANEOUS, Retrospective Studies, Pharmacology, Morphine, business.industry, Incidence (epidemiology), Retrospective cohort study, Opioid use disorder, Off-Label Use, Original Articles, Opioid-Related Disorders, medicine.disease, Confidence interval, Buprenorphine, 3. Good health, Analgesics, Opioid, Opioid, Cohort, business, Delivery of Health Care, Methadone, medicine.drug
Abstract: AIMS: Several addictovigilance studies have described the off‐label use of morphine sulfate (MS) for nonchronic pain in opioid use disorder (OUD) patients as an alternative to conventional opioid substitution treatments (OSTs). This study primarily sought to compare the incidence of unintentional opioid‐related overdose in the year following the prescription initiation in off‐label MS users, compared to OST‐maintained patients. METHODS: Sequential cohorts of OUD patients who were regularly dispensed MS, buprenorphine, or methadone, between 1 April 2012 and 31 December 2014, were retrospectively identified using the French nationwide healthcare data system. The incidence of overdoses, deaths, doctor shopping, and complications of a viral, bacterial or thrombotic nature, was compared using the Cox regression method. RESULTS: Overall, 1075, 20 834 and 9778 OUD patients without chronic‐pain were included in the MS, buprenorphine, and methadone cohorts, respectively. Overdose incidence was 3.8 (P
Published: 2019

3. Depression Severity as a Risk Factor of Sarcopenic Obesity in Morbidly Obese Patients

Author: Céline Lambert, Clément Lahaye, C. Palmier-Forestier, M. Pouget, V. Venant, N. Farigon, Bruno Pereira, E. Gentes, Carla Domingues-Faria, J. Debarges, Yves Boirie, M. Miolanne, Nutrition clinique, Centre Hospitalier Universitaire Gabriel Montpied, Biostatistiques, Danone Research, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Unité de Nutrition Humaine (UNH), and Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])
Subjects: Adult, Male, medicine.medical_specialty, Physical disability, muscle, 030309 nutrition & dietetics, Population, Medicine (miscellaneous), macromolecular substances, sarcopenia, 03 medical and health sciences, Grip strength, 0302 clinical medicine, Risk Factors, Internal medicine, mental disorders, Prevalence, Humans, Medicine, Sarcopenic obesity, Muscle Strength, Obesity, 030212 general & internal medicine, Risk factor, education, Depression (differential diagnoses), 0303 health sciences, education.field_of_study, Nutrition and Dietetics, business.industry, musculoskeletal, neural, and ocular physiology, [SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology, medicine.disease, mobility, Obesity, Morbid, 3. Good health, nervous system, Sarcopenia, depression, Female, Geriatrics and Gerontology, business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract: Etiopathogenic factors of physical disability in obesity are numerous, underestimated and not sought in the non-geriatric population. Amongst these factors, depression may favor the development of sarcopenic obesity by reducing strength and physical performance even in the absence of overt muscle loss. Objectives and participants: To study the link between depression status and muscle functional disorders (dynapenia) in a population of adult subjects with severe and morbid obesity.Patients were assessed for body composition, grip strength, the Short Physical Performances Battery test (SPPB), for depression according to the Beck II score as well as for metabolic parameters through biological tests.In 373 obese subjects (mean age 44 ± 13y and BMI 43 ± 6 kg/m²), the prevalence of depression was 53% with 18% having mild depression, 18% moderate depression and 16% severe depression. Depression was significantly related to dynapenia: 62% of dynapenic (D) patients suffered from depression compared to 50% of non-dynapenic (ND) patients (p = 0.036). The Beck questionnaire score for D patients was 20 ± 13 and 15 ± 10 for ND patients (p = 0.001). The depression intensity was significantly correlated with dynapenia with D patients having a higher severe depression degree than ND patients (30% versus 11%; p0.0001). Fat-free to fat mass ratio was also significantly correlated with dynapenia (p = 0.01). In multivariate analysis, the presence of depression was twice as likely to be associated with dynapenia.Depression is associated with a reduction of muscle function in severe obesity in relation to its severity and to changes in fat to fat-free mass, suggesting that screening and prevention of sarcopenic obesity should be considered in adult obese patients with depression.
Published: 2019

4. Level of obesity is directly associated with the clinical and functional consequences of knee osteoarthritis

Author: Benjamin Raud, Chloé Gay, Candy Guiguet-Auclair, Armand Bonnin, Laurent Gerbaud, Bruno Pereira, Martine Duclos, Yves Boirie, Emmanuel Coudeyre, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Université Clermont Auvergne (UCA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Clermont Auvergne (UCA), Médecine physique et de réadaptation, Centre Hospitalier Universitaire de Clermont-Ferrand, Santé publique, Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Pascal, Centre National de la Recherche Scientifique (CNRS), SIGMA Clermont, Délégation Recherche Clinique et Innovation, Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Nutrition clinique, Centre Hospitalier Universitaire Gabriel Montpied, Unité de Nutrition Humaine (UNH), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), CHU Clermont-Ferrand, Institut Pascal (IP), SIGMA Clermont (SIGMA Clermont)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Innovatherm cluster Clermont-Ferrand Communaute Region Auvergne-Rhone-Alpes, and ProdInra, Archive Ouverte
Subjects: Male, medicine.medical_specialty, WOMAC, Epidemiology, Cross-sectional study, Visual analogue scale, lcsh:Medicine, Osteoarthritis, Overweight, Article, Body Mass Index, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Risk Factors, Surveys and Questionnaires, Internal medicine, Humans, Medicine, Obesity, lcsh:Science, Exercise, Aged, 030203 arthritis & rheumatology, 2. Zero hunger, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Multidisciplinary, business.industry, lcsh:R, Middle Aged, Osteoarthritis, Knee, medicine.disease, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, Cross-Sectional Studies, Cartilage, Disease Progression, Quality of Life, lcsh:Q, Female, France, medicine.symptom, business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Body mass index, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, 030217 neurology & neurosurgery
Abstract: Obesity is one of the most important risk factors of knee osteoarthritis (KOA), but its impact on clinical and functional consequences is less clear. The main objective of this cross-sectional study was to describe the relation between body mass index (BMI) and clinical expression of KOA. Participants with BMI ≥ 25 kg/m2 and KOA completed anonymous self-administered questionnaires. They were classified according to BMI in three groups: overweight (BMI 25–30 kg/m2), stage I obesity (BMI 30–35 kg/m2) and stage II/III obesity (BMI ≥ 35 kg/m2). The groups were compared in terms of pain, physical disability, level of physical activity (PA) and fears and beliefs concerning KOA. Among the 391 individuals included, 57.0% were overweight, 28.4% had stage I obesity and 14.6% had stage II/III obesity. Mean pain score on a 10-point visual analog scale was 4.3 (SD 2.4), 5.0 (SD 2.6) and 5.2 (SD 2.3) with overweight, stage I and stage II/III obesity, respectively (p = 0.0367). The mean WOMAC function score (out of 100) was 36.2 (SD 20.1), 39.5 (SD 21.4) and 45.6 (SD 18.4), respectively (p = 0.0409). The Knee Osteoarthritis Fears and Beliefs Questionnaire total score (KOFBEQ), daily activity score and physician score significantly differed among BMI groups (p = 0.0204, p = 0.0389 and p = 0.0413, respectively), and the PA level significantly differed (p = 0.0219). We found a dose–response relation between BMI and the clinical consequences of KOA. Strategies to treat KOA should differ by obesity severity. High PA level was associated with low BMI and contributes to preventing the clinical consequences of KOA.
Published: 2020

5. Appetite control and exercise: Does the timing of exercise play a role?

Author: Alicia Fillon, Yves Boirie, David Thivel, Marie-Eve Mathieu, Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), École de kinésiologie et des sciences de l'activité physique [Université de Montréal], Department of Medicine, Université de Montréal, Université de Montréal (UdeM), Nutrition clinique, CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Unité de Nutrition Humaine (UNH), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), EA 3533, Laboratoire des Adaptations Métaboliques à l’Exercice en conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne (UCA), École de kinésiologie et des sciences de l’activité physique, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), and Centre Hospitalier Universitaire Gabriel Montpied
Subjects: medicine.medical_specialty, Evening, media_common.quotation_subject, Energy balance, Appetite, Experimental and Cognitive Psychology, Physical exercise, Overweight, Affect (psychology), 03 medical and health sciences, Behavioral Neuroscience, 0302 clinical medicine, Physical medicine and rehabilitation, medicine, Food and Nutrition, 0501 psychology and cognitive sciences, 050102 behavioral science & comparative psychology, Timing, Meals, Exercise, Morning, media_common, Appetite control, business.industry, Appetite Regulation, 05 social sciences, medicine.disease, Obesity, Alimentation et Nutrition, medicine.symptom, business, Energy Intake, Energy Metabolism, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, 030217 neurology & neurosurgery
Abstract: Epub ahead of print; The prevention and management of chronic diseases, particularly overweight and obesity, relies on multidisciplinary strategies mainly combining dietary approaches with physical activity. Recently, the timing of exercise (time of the day as well as delay/position relative to a meal) has been suggested as an important parameter to consider when prescribing physical activity. Some studies have for instance shown the interest of the timing of exercise on the glycemia, sleep and body composition regulation. However, the impact of exercise-timing on appetite control and energy intake remains unclear. This is why, the present paper questions whether physical exercise, depending on its timing during the day and related to a meal, can affect energy intake, appetite sensations and food reward. Although evidences remain actually limited, exercising during the morning; and particularly close to lunch, might have a better impact on overall energy balance through reduced subsequent energy intake, without leading to compensatory intakes at the following meals. Importantly, dealing with the timing of exercise to optimize energy balance (and affect energy intake and appetite) does not only require to consider its time during the day (morning vs. afternoon or evening), but also and maybe mainly its order/position (pre vs. post) and delay regarding meals. While the actual literature remains limited in this area, the present paper tends to highlight the importance of considering the timing of exercise to optimize our impact on the overall energy balance, and to encourage the elaboration of further studies to better understand and determine the potential effect of this timing of exercise, in order to find the best combination between the different exercise characteristics, intensity, duration, modality, to empower these effects.
Published: 2020

6. Sleep-disordered breathing in adolescents with obesity: When does it start to affect cardiometabolic health?

Author: Sergio Tufik, Julie Masurier, Bruno Pereira, David Thivel, Marco Túlio de Mello, Yves Boirie, Ana Raimunda Dâmaso, Gustavo Antonio Moreira, Marcia Pradella-Hallinan, Laurie Isacco, Martine Duclos, Alicia Fillon, Maud Miguet, Johanna Roche, Aurore Guyon, Patricia Franco, Fabienne Mougin, Flávia Campos Corgosinho, Valérie Gillet, Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Faculdade de Nutrição, Universidade Federal de Goiás, Escola Paulista de Medicina, Universidade Federal de São Paulo, Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Hôpital Femme Mère Enfant, Hospices Civils de Lyon (HCL), Université de Lyon, Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS), Université Jean Monnet (Saint-Etienne), Departameno de Psicobiologia, Universidade Federal de Minas Gerais, Centre Médical Santé Sommeil ELLIPSE, Biostatistiques (DRCI), CHU Clermont-Ferrand, Médecine du sport et explorations fonctionnelles, CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Unité de Nutrition Humaine (UNH), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Nutrition clinique, Centre de SSR Nutrition-Obésité UGECAM, Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Jean Monnet - Saint-Étienne (UJM), UE3533, Laboratoire des Adaptations Métaboliques à l’Exercice en conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne (UCA), Centre de recherche en Neurosciences de Lyon (CRNL), Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Centre Hospitalier Universitaire Gabriel Montpied, UE 3533, Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques - Clermont Auvergne (AME2P), Faculté des Sciences du SportFaculté des Sciences du Sport, UFR STAPS-Université Clermont Auvergne (UCA), Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Centre National de la Recherche Scientifique (CNRS)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB), EA 3533, Université Clermont Auvergne (UCA)-Faculté des Sciences du SportFaculté des Sciences du Sport, UFR STAPS, and Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)
Subjects: Blood Glucose, Male, Sleep-disordered breathing, genetic structures, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous), Blood Pressure, Polysomnography, 030204 cardiovascular system & hematology, MetScore, 0302 clinical medicine, Risk Factors, Lung, Adiposity, Nutrition and Dietetics, medicine.diagnostic_test, Respiration, Age Factors, Sleep apnea, Pediatric obesity, Lipids, Metabolic syndrome, humanities, 3. Good health, Cardiology, Breathing, cardiovascular system, Female, France, Cardiology and Cardiovascular Medicine, Brazil, medicine.medical_specialty, Adolescent, education, 030209 endocrinology & metabolism, Affect (psychology), Risk Assessment, 03 medical and health sciences, Sleep Apnea Syndromes, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Internal medicine, medicine, Humans, cardiovascular diseases, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, business.industry, medicine.disease, Obesity, Cardiometabolic risk, nervous system diseases, respiratory tract diseases, Clinical trial, Blood pressure, Insulin Resistance, business, Energy Metabolism, Sleep, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Biomarkers
Abstract: International audience; Background and aims: Pediatric obesity and sleep-disordered breathing (SDB) are associated with cardiometabolic risk (CMR), but the degree of severity at which SDB affects cardiometabolic health is unknown. We assessed the relationship between the CMR and the apnea-hypopnea index (AHI), to identify a threshold of AHI from which an increase in the CMR is observed, in adolescents with obesity. We also compared the clinical, cardiometabolic and sleep characteristics between adolescents presenting a high (CMR+) and low CMR (CMR-), according to the threshold of AHI.Methods and results: 114 adolescents with obesity were recruited from three institutions specialized in obesity management. Sleep and SDB as assessed by polysomnography, anthropometric parameters, fat mass (FM), glucose and lipid profiles, and blood pressure (BP) were measured at admission. Continuous (MetScoreFM) and dichotomous (metabolic syndrome, MetS) CMR were determined. Associations between MetScoreFM and AHI adjusted for BMI, sex and age were assessed by multivariable analyses. Data of 82 adolescents were analyzed. Multivariable analyses enabled us to identify a threshold of AHI = 2 above which we observed a strong and significant association between CMR and AHI (Cohen's d effect-size = 0.57 [0.11; 1.02] p = 0.02). Adolescents with CMR+ exhibited higher MetScoreFM (p < 0.05), insulin resistance (p < 0.05), systolic BP (p < 0.001), sleep fragmentation (p < 0.01) and intermittent hypoxia than CMR- group (p < 0.0001). MetS was found in 90.9% of adolescents with CMR+, versus 69.4% in the CMR- group (p < 0.05).Conclusions: The identification of a threshold of AHI ≥ 2 corresponding to the cardiometabolic alterations highlights the need for the early management of SDB and obesity in adolescents, to prevent cardiometabolic diseases.
Published: 2020

7. Stress management in obesity during a thermal spa residential programme (ObesiStress): protocol for a randomised controlled trial study

Author: Yves Boirie, Daniela M. Pfabigan, Omar Izem, Magalie Miolanne-Debouit, N. Farigon, Bruno Pereira, Laurie Mobdillon, Guillaume T. Vallet, Armand Abergel, Pascale Duché, Gil Boudet, Philippe Obert, Shihui Han, Elodie Chaplais, Daniel Courteix, Frédéric Dutheil, Audrey Vilmant, Martial Mermillod, Laboratoire de Psychologie Sociale et Cognitive - Clermont Auvergne (LAPSCO), Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut de Médecine du Travail, CHU Clermont-Ferrand-Université d'Auvergne - Clermont-Ferrand I (UdA), Laboratoire Développement, Adaptation et Handicap (DevAH), Unité de Biostatistiques [CHU Clermont-Ferrand] (Département de la recherche clinique et de l'innovation - DRCI), CHU Clermont-Ferrand, Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Faculté des Sciences du SportFaculté des Sciences du Sport, UFR STAPS, Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne), Impact de l'Activité Physique sur la Santé (IAPS), Université de Toulon (UTLN), Service d'Hépato-Gastroentérologie [CHRU Clermont-Ferrand], Centre Hospitalier Universitaire de Clermont-Ferrand, Peking University [Beijing], PKU-IDG/McGovern Institute For Brain Research, Centre de recherche en économie de Grenoble (CREG), Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Grenoble Alpes (UGA), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Physiopathologie des adaptations cardiovasculaires à l'Exercice, Avignon Université (AU), EA4278 Laboratoire de Pharm-Ecologie Cardiovasculaire (LaPEC), Nutrition clinique, Centre Hospitalier Universitaire Gabriel Montpied, nutrition clinique, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université, Université Clermont Auvergne (UCA), Centre National de la Recherche Scientifique (CNRS), Service Santé Travail Environnement, EA 3450, Université de Lorraine (UL), Département Recherche Clinique et Innovation, EA 3533, Laboratoire des Adaptations Métaboliques à l’Exercice en conditions Physiologiques et Pathologiques (AME2P), Laboratoire Impact de l’Activité Physique sur la Santé, Hépatologie Gastro-Entérologie, Centre Hospitalier Universitaire Estaing, UMR 6284, University Beijing, Laboratoire de Psychologie et NeuroCognition (LPNC), Université Grenoble Alpes (COMUE) (UGA), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), EA 4278, laboratoire de Pharm-Ecologie Cardiovasculaire (LaPEC ), Biostatistiques, Danone Research, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Université Clermont Auvergne (UCA)-Institut National de la Recherche Agronomique (INRA), Laboratoire de Psychologie Sociale et Cognitive (LAPSCO), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Développement, Adaptation et Handicap. Régulations cardio-respiratoires et de la motricité (DevAH), Unité de Biostatistiques [CHU Clermont-Ferrand], Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI), CHU Clermont-Ferrand-CHU Clermont-Ferrand, UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Ferrand (UFR STAPS - UBP), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP), Service d'Hépatologie Gastro-entérologie [CHU Clermont-Ferrand], CHU Estaing [Clermont-Ferrand], Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Auvergne Rhone-Alpes University Hospital of Clermont-Ferrand European Regional Development Fund (Fonds Europeen de Developpement Economique et Regional), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Ferrand (UFR STAPS - UBP), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP), and Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA)
Subjects: musculoskeletal diseases, Stress management, medicine.medical_specialty, obesity, Cardiovascular Medicine, Overweight, Body Mass Index, law.invention, 03 medical and health sciences, stress, 0302 clinical medicine, Quality of life, Randomized controlled trial, prevention, Heart Rate, law, Protocol, Humans, Medicine, 030212 general & internal medicine, ComputingMilieux_MISCELLANEOUS, Randomized Controlled Trials as Topic, 2. Zero hunger, business.industry, Public health, heart rate variability, Hyperthermia, Induced, General Medicine, Anthropometry, medicine.disease, Obesity, 3. Good health, spa bath, Body Composition, Quality of Life, Physical therapy, France, medicine.symptom, business, Body mass index, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Biomarkers, Stress, Psychological, 030217 neurology & neurosurgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: IntroductionStress and obesity are two public health issues. The relationship between obesity and stress is biological through the actions of stress on the major hormones that regulate appetite (leptin and ghrelin). Many spa resorts in France specialise in the treatment of obesity, but no thermal spa currently proposes a specific programme to manage stress in obesity. The ObesiStress protocol has been designed to offer a new residential stress management programme. This thermal spa treatment of obesity implements stress management strategies as suggested by international recommendations.Methods and analysis140 overweight or obese participants with a Body Mass Index of >25 kg/m2 and aged over 18 years will be recruited. Participants will be randomised into two groups: a control group of usual practice (restrictive diet, physical activity and thermal spa treatment) and an intervention group with stress management in addition to the usual practice. In the present protocol, parameters will be measured on five occasions (at inclusion, at the beginning of the spa (day 0), at the end of the spa (day 21), and at 6 and 12 months). The study will assess the participants’ heart rate variability, cardiac remodelling and function, electrodermal activity, blood markers, anthropometric profile, body composition, psychology and quality of life via the use of questionnaires and bone parameters.Ethics and disseminationThe ObesiStress protocol complies with the ethics guidelines for Clinical Research and has been approved by the ethics committee (CPP Sud-Est VI, Clermont-Ferrand - ANSM: 2016-A01774-47). This study aimed to highlight the efficacy of a 21-day thermal spa residential programme of stress management in obesity through objective measurements of well-being and cardiovascular morbidity. Results will be disseminated during several research conferences and articles published in peer-reviewed journals.Trial registration numberNCT03578757.
Published: 2019

8. Transcultural adaptation and French validation of the Pain Sensitivity Questionnaire

Author: Sylvie Eschalier, Ruth Ruscheweyh, Vedat Eljezi, Claude Dubray, Christian Dualé, Candy Guiguet-Auclair, Ulrich Bauer, Brigitte Storme, CHU Gabriel Montpied (CHU), CHU Clermont-Ferrand, CIC Clermont Ferrand, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre de Pharmacologie Clinique-CHU Gabriel-Montpied, Neuro-Dol (Neuro-Dol), Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Pôle Cardiologie médicale et chirurgicale, Centre Hospitalier Universitaire Gabriel Montpied, Centre d’Investigation Clinique (CIC), PEPRADE, Centre Hospitalier Universitaire de Clermont-Ferrand, and Institute of Science and Technology [Austria] (IST Austria)
Subjects: medicine.medical_specialty, Psychometrics, Intraclass correlation, [SDV]Life Sciences [q-bio], Pain medicine, Concurrent validity, 03 medical and health sciences, 0302 clinical medicine, Cronbach's alpha, [SDV.SP.MED]Life Sciences [q-bio]/Pharmaceutical sciences/Medication, 030202 anesthesiology, medicine, ComputingMilieux_MISCELLANEOUS, business.industry, Cold pressor test, General Medicine, Anesthesiology and Pain Medicine, Convergent validity, Anesthesia, Physical therapy, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, Anxiety, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], medicine.symptom, business, 030217 neurology & neurosurgery
Abstract: To validate a French translation of the Pain Sensitivity Questionnaire (PSQ), which is a valuable tool to predict an individual’s natural disposition to feel pain that could be used after surgery. We studied content validity, internal consistency, convergent validity (anxiety, depression and catastrophism) and test-retest reliability of the French version of the PSQ (PSQ-F) in 146 patients either before scheduled surgery or during pregnancy; then, convergent and concurrent validity in 85 healthy volunteers submitted to nociceptive tests. Internal consistency of the PSQ-F was found to be excellent, with Cronbach’s α at 0.866, 0.886, and 0.927, respectively for its “minor”, “moderate” and “total” scores. Test-retest reliability was significant, with intraclass correlation coefficients at 0.629, 0.629, and 0.635, respectively for the above- mentioned scores. These three scores correlated with anxiety, depression and catastrophizing scores in patients, but not in healthy volunteers, possibly because of low and few variant psychometric scores in this group. They were inversely correlated to the temperature needed to evoke heat pain rated 6 out of 10, but not to the mechanical pain threshold (electronic von Frey), nor to the heat pain threshold. Finally, they directly correlated to the pain induced by the cold pressor test (minor and total scores only). This validated version can now be used by French-speaking researchers and physicians. www.ClinicalTrials.gov (NCT03113903); 14 April, 2017.
Published: 2019

9. Effet de la longueur du complexe musculo-tendineux sur les différences de fatigue neuromusculaire entre garçons pré-pubères et hommes

Author: Piponnier, Enzo, Martin, Vincent, Chalchat, Emeric, Bontemps, Bastien, Jagot, Kévin, Julian, Valérie, Bocock, Olivia, Duclos, Martine, Ratel, Sébastien, Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Laboratoire Motricité Humaine Expertise Sport Santé (LAMHESS), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université de Toulon (UTLN)-Université Côte d'Azur (UCA), service du sport et explorations fonctionnelles, CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, CHU Clermont-Ferrand, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques - Clermont Auvergne (AME2P), Faculté des Sciences du SportFaculté des Sciences du Sport, UFR STAPS-Université Clermont Auvergne (UCA), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Université de Toulon (UTLN), Centre Hospitalier Universitaire Gabriel Montpied, CHU Gabriel Montpied (CHU), Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université, Martin, Vincent, and Université Nice Sophia Antipolis (1965 - 2019) (UNS)
Subjects: [SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2019

10. eMouve : la 1ère application scientifique sur smartphone pour promouvoir les activités de faible intensité et prévenir les maladies chroniques non transmissibles

Author: Sylvie Rousset, Romain Guidoux, Ludivine Paris, Nicolas Farigon, Yves Boirie, Philippe Lacomme, Raksmey Phan, Daniel Saboul, Martine Duclos, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), IP Leanware, Nutrition Clinique, Centre Hospitalier Universitaire de Clermont-Ferrand, Nutrition clinique, Centre Hospitalier Universitaire Gabriel Montpied, Centre National de la Recherche Scientifique (CNRS), Université Clermont Auvergne (UCA), Centre Ingénierie et Santé, Ecole Nationale Supérieure des Mines de Saint-Etienne, Université de Lyon, Médecine du sport et explorations fonctionnelles, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), CHU Clermont-Ferrand, CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), and Institut Mines-Télécom [Paris] (IMT)
Subjects: application smartphone, activités physiques spontanées, indice de masse corporelle, [INFO.INFO-OS]Computer Science [cs]/Operating Systems [cs.OS], conditions habituelles de vie, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, sédentarité
Abstract: L’inactivité physique et les comportements sédentaires sont impliqués dans le développement des maladies chroniques. Le but de cette étude est de comparer la quantité et la répartition des activités physiques et de la sédentarité dans 2 populations d’adultes normo-pondérés (NP) et en surpoids (SP). Les comportements ont été évalués en utilisant l’application eMouve qui collecte des données d’accélérométrie. Les algorithmes implémentés sur la plateforme ActivCollector discriminent précisément les comportements sédentaires et actifs en 4 catégories : immobilité, activité d’intensité légère, modérée et vigoureuse. Chez les personnes en surpoids, les comportements sédentaires durent plus longtemps (81.4% vs. 65 % de la période éveillée), à l’inverse le temps passé en activité d’intensité légère est plus bref (15.4% vs 29.5 %). Les périodes de sédentarité des normo-pondéraux sont brèves (1-5 min) et fréquentes, alors que celle des personnes en surpoids sont plus longues (15-30 min). Les périodes d’activité légère de 1-5 min sont plus fréquentes chez les SP alors que celles de 5-15 et 15-30 min sont plus représentées chez les NP. Ainsi l’évaluation des comportements à l’aide d’une application mobile permet de différencier les 2 populations au regard de leurs profils de sédentarité et d’activité physique d’intensité légère.
Published: 2019

11. The intrinsically labeled protein approach is the preferred method to quantify the release of dietary protein-derived amino acids into the circulation

Author: Nicholas A. Burd, Luc J. C. van Loon, Jean Nyakayiru, Jorn Trommelen, Andrew M. Holwerda, Stefan H. M. Gorissen, Olav Rooyackers, Yves Boirie, Humane Biologie, RS: NUTRIM - R3 - Respiratory & Age-related Health, Promovendi NTM, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, Physiotherapy, Human Physiology and Anatomy, Human Physiology and Sports Physiotherapy Research Group, Department of Human Biology, University of Cape Town, Division of Anaesthesia and Intensive Care, CLINTEC, Karolinska Institute, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Nutrition clinique, Centre Hospitalier Universitaire Gabriel Montpied, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), CHU Gabriel Montpied [Clermont-Ferrand], and CHU Clermont-Ferrand-CHU Clermont-Ferrand
Subjects: 0301 basic medicine, medicine.medical_specialty, Physiology, INCREASES, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, 03 medical and health sciences, 0302 clinical medicine, DIGESTION, Physiology (medical), Internal medicine, medicine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], ABSORPTION, Amino Acids, chemistry.chemical_classification, Chemistry, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Amino acid, Diet, Kinetics, 030104 developmental biology, Endocrinology, Dietary protein, Biochemistry, Dietary Proteins, Digestion, INGESTION
Abstract: The intrinsically labeled protein approach is the preferred method to quantify the release of dietary protein-derived amino acids into the circulation
Published: 2019

12. Effect of muscle-tendon unit length on difference in neuromuscular fatigue between boys and men

Author: Piponnier, Enzo, Ratel, Sébastien, Bontemps, Bastien, Chalchat, Emeric, Julian, Valérie, Bocock, Olivia, Duclos, Martine, Martin, Vincent, Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques - Clermont Auvergne (AME2P), Faculté des Sciences du SportFaculté des Sciences du Sport, UFR STAPS-Université Clermont Auvergne (UCA), Laboratoire Motricité Humaine Expertise Sport Santé (LAMHESS), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Université de Toulon (UTLN), service du sport et explorations fonctionnelles, Centre Hospitalier Universitaire Gabriel Montpied, CHU Gabriel Montpied (CHU), CHU Clermont-Ferrand, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université, Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université de Toulon (UTLN)-Université Côte d'Azur (UCA), CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), and Martin, Vincent
Subjects: [SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2019

13. Effect of muscle length on neuromuscular fatigue of the knee extensors in boys and men

Author: Piponnier, Enzo, RATEL, Sébastien, Bontemps, Bastien, Chalchat, Emeric, Julian, Valérie, Bocock, Olivia, Duclos, Martine, Martin, Vincent, Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), service du sport et explorations fonctionnelles, CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, CHU Clermont-Ferrand, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques - Clermont Auvergne (AME2P), Faculté des Sciences du SportFaculté des Sciences du Sport, UFR STAPS-Université Clermont Auvergne (UCA), Centre Hospitalier Universitaire Gabriel Montpied, CHU Gabriel Montpied (CHU), Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université, and Martin, Vincent
Subjects: [SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2019

14. Impact of downhill running on body composition and energy expenditure

Author: Touron, Julianne, Perrault, H., Pereira, Bruno, Costes, Fréderic, Richard, Ruddy, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Faculty of Health Sciences, University of Ottawa [Ottawa] (uOttawa), Biostatistiques, Danone Research, Centre Hospitalier Universitaire de Clermont-Ferrand, Médecine du sport et explorations fonctionnelles, Centre Hospitalier Universitaire Gabriel Montpied, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), University of Ottawa [Ottawa], CHU Clermont-Ferrand, CHU Gabriel Montpied [Clermont-Ferrand], and CHU Clermont-Ferrand-CHU Clermont-Ferrand
Subjects: Fat mass, Lean mass, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Calorimetric cages, Eccentric training
Abstract: Poster session 1Poster session 1; We aimed to compare the effects of 8-week eccentric versus concentric exercise training in rats on body composition and energy expenditure, since these parameters have not been fully investigated. Animals were assigned to group 1) control, 2) +15% uphill-running slope (CON), 3) -15% downhill- running slope (ECC15, iso-power output) or 4) -30% downhill-running slope (ECC30, iso-VO2). Total body mass increased in all groups over the 8 weeks. A significant gain in fat mass was only observed for control group (20.71±1.99g) compared to CON (-4.8±6.18g); ECC15 (0.6±3.32g) and ECC30 (2.6±6.01g). A gain in lean mass was mainly seen for ECC15 (88.9±6.85g, p=0.09) and ECC30 (101.6±11.07g, p=0.02). Basal metabolic rate increased for all running groups. Thereby, the impact of training on lean mass is enhanced with ECC30 compared to CON, and adaptations are still observed for lower VO2 (ECC15). Thus low intensity eccentric exercise training could be part of body composition regulation strategies.
Published: 2019

15. Validation of intracardiac shunt using thoracic bioimpedance and inert gas rebreathing in adults before and after percutaneous closure of atrial septal defect in a cardiology research unit: study protocol

Author: Bruno Pereira, Jean-René Lusson, Frédéric Costes, Aurélie Chalard, Romain Trésorier, Hélène Perrault, Laura Filaire, Ruddy Richard, Claire Dauphin, Thoracic and Endocrine Surgery, Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), UNICANCER-UNICANCER, Cardiology and Vascular Department, CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Faculty of Health Sciences, University of Ottawa [Ottawa], Respiratory and Epidemiology Clinical Research Unit, Montreal Chest Institute, McGill University Health Center [Montreal] (MUHC)-McGill University Health Center [Montreal] (MUHC), MCGill University Health Centre, Biostatistiques, Danone Research, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), médecine du sport et explorations fonctionnelles, Centre Jean Perrin, Centre Hospitalier Universitaire Gabriel Montpied, University of Ottawa [Ottawa] (uOttawa), Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), and Richard, Ruddy
Subjects: atrial septal defect (ASD), cardiac output, inert gas rebreathing, shunt quantification, thoracic bioimpedance, medicine.medical_specialty, Cardiac output, Percutaneous, Médecine humaine et pathologie, Cardiologie et système cardiovasculaire, Doppler echocardiography, Cardiovascular Medicine, Cardiography, Impedance, Noble Gases, Intracardiac injection, Heart Septal Defects, Atrial, 03 medical and health sciences, 0302 clinical medicine, Oxygen Consumption, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Internal medicine, Protocol, Medicine, Humans, 030212 general & internal medicine, Independent research, medicine.diagnostic_test, business.industry, General Medicine, Echocardiography, Doppler, 3. Good health, Clinical trial, Cardiology and cardiovascular system, Treatment Outcome, Breath Tests, Cardiology, Human health and pathology, Inert gas rebreathing, business, 030217 neurology & neurosurgery, Shunt (electrical), [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: IntroductionIntrathoracic shunt quantification is a major factor for appropriate clinical management of heart and pulmonary diseases. Intracardiac shunts quantified by pulmonary to systemic output ratio (Qp/Qs) are generally assessed by Doppler echocardiography, MRI or catheterisation. Recently, some authors have suggested the concomitant use of thoracic bioimpedance (TB) and inert gas rebreathing (IGR) techniques for shunt quantification. The purpose of this study is to validate the use of this approach under conditions where shunt fraction is directly quantified such as in patients with isolated atrial septal defect (ASD).Methods and analysisThis trial is a prospective, observational single-centre, non-blinded study of adults seen for percutaneous closure of ASD. Qp/Qs ratio will be directly measured by Doppler echocardiography and direct Fick. IGR and TB will be used simultaneously to measure the cardiac output before and after closure: the ratio of outputs measured by IGR and TB reflecting the shunt fraction. The primary outcome will be the comparison of shunt values measured by TB-IGR and Doppler echocardiography.Ethics and disseminationThe study has been approved by an independent Research Ethics Committee (2017-A03149-44 Fr) and registered as an official clinical trial. The results will be published in a peer-reviewed journal.Trial registration numberNCT03437148; Pre-results.
Published: 2019

16. Impact of Eccentric or Concentric Training on Body Composition and Energy Expenditure

Author: Jérôme Salles, Corinne Malpuech-Brugère, Julianne Touron, Christophe Montaurier, Jean-Paul Rigaudière, Juliette Auclair-Ronzaud, Véronique Coxam, Valérie Julian, Julien Hermet, Hélène Perrault, Frédéric Costes, Laura Maisonnave, Philippe Deat, Bruno Pereira, Ruddy Richard, Patrice Lebecque, Stéphane Walrand, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Faculty of Health Sciences, University of Ottawa [Ottawa] (uOttawa), Université Clermont Auvergne (UCA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Clermont Auvergne (UCA), Délégation à la Recherche Clinique et à l'Innovation (DRCI), Centre Hospitalier Universitaire de Clermont-Ferrand, Médecine du sport et explorations fonctionnelles, Centre Hospitalier Universitaire Gabriel Montpied, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), University of Ottawa [Ottawa], Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), CHU Clermont-Ferrand, CHU Gabriel Montpied [Clermont-Ferrand], and CHU Clermont-Ferrand-CHU Clermont-Ferrand
Subjects: Male, Osteogenic response, Muscle Proteins, Physical Therapy, Sports Therapy and Rehabilitation, Concentric, Body Mass Index, Running, 03 medical and health sciences, Whole body composition, Random Allocation, 0302 clinical medicine, Animal science, Bone Density, Physical Conditioning, Animal, Eccentric, Animals, Humans, Orthopedics and Sports Medicine, Rats, Wistar, Muscle, Skeletal, Mathematics, Bone mineral, Physical conditioning, Fat mass, Lean mass, 030229 sport sciences, Downhill running, Energy expenditure, Models, Animal, Lean body mass, Body Composition, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Calorimetric cages, Energy Metabolism, Body mass index
Abstract: Epub ahead of print; PURPOSE: To compare the effects of 8-week eccentric (ECC) versus concentric (CON) training using downhill and uphill running in rats on whole body composition, bone mineral density (BMD), and energy expenditure (EE). METHODS: Animals were randomly assigned to one of the following groups: 1) control (CTRL), 2) +15% uphill-running slope (CON), 3) -15% downhill-running slope (ECC15) and 4) -30% downhill-running slope (ECC30). Those programs enabled to achieve conditions of iso-power output for CON and ECC15 and of iso-oxygen uptake (VO2) for CON and ECC30. Trained rats ran 45min at 15 mmin five times per week. Total (TBM), fat (FBM) and lean (LBM) body mass measured through EchoMRI, and 24-hour EE including basal metabolic rate (BMR) assessed using PhenoMaster/LabMaster cage system were obtained before and after training. At sacrifice, the right femur was collected for bone parameters analysis. RESULTS: While TBM increased in all groups over the 8-week period, almost no change occurred for FBM in exercised groups (CON: -4.8+/-6.18 g; ECC15: 0.6+/-3.32 g; ECC30: 2.6+/-6.01 g). The gain in LBM was mainly seen for ECC15 (88.9+/-6.85 g) and ECC30 (101.6+/-11.07 g). ECC was also seen to positively affect BMD. An increase in BMR from baseline was seen in exercise groups (CON: 13.9+/-4.13 kJ.day; ECC15: 11.6+/-5.10 kJ.day; ECC30: 18.3+/-4.33 kJ.day) but not in CTRL one. This difference disappeared when BMR was normalized for LBM. CONCLUSIONS: Results indicate that for iso-VO2 training, the impact on LBM and BMD is enhanced with ECC as compared to CON, and that for iso-power but lower VO2 ECC, an important stimulus for adaptation is still observed. This provides further insights for the use of ECC in populations with cardiorespiratory exercise limitations.
Published: 2019

17. Children Exhibit a More Comparable Neuromuscular Fatigue Profile to Endurance Athletes Than Untrained Adults

Author: Valérie Julian, Anthony J. Blazevich, Emeric Chalchat, Sébastien Ratel, Olivia Bocock, Vincent Martin, Enzo Piponnier, Bastien Bontemps, Martine Duclos, Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Centre for Exercise and Sports Science Research, School of Medical and Health Sciences, Edith Cowan University, service du sport et explorations fonctionnelles, CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Université de Bordeaux (UB), Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Edith Cowan University (ECU), CHU Clermont-Ferrand, Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques - Clermont Auvergne (AME2P), Faculté des Sciences du SportFaculté des Sciences du Sport, UFR STAPS-Université Clermont Auvergne (UCA), Centre Hospitalier Universitaire Gabriel Montpied, and Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université
Subjects: medicine.medical_specialty, Physiology, Vastus medialis, [SDV]Life Sciences [q-bio], growth, peripheral fatigue, Isometric exercise, lcsh:Physiology, young people, 03 medical and health sciences, 0302 clinical medicine, Femoral nerve, Physiology (medical), [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Medicine, high-intensity exercise, ComputingMilieux_MISCELLANEOUS, Original Research, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, lcsh:QP1-981, Knee extensors, biology, business.industry, Athletes, 030229 sport sciences, biology.organism_classification, central fatigue, Neuromuscular fatigue, 030220 oncology & carcinogenesis, Time course, Physical therapy, business
Abstract: International audience; The present study compared neuromuscular fatigue profiles between children, untrained adults and adult endurance athletes during repeated maximal muscle contractions. Eighteen prepubertal boys, 19 untrained men and 13 endurance male athletes performed 5-s maximal voluntary isometric knee extensor contractions (MVICs) interspersed with 5-s recovery until MVIC reached 60% of its initial value. Single and doublet magnetic stimulations were delivered to the femoral nerve to quantify the time course of potentiated twitch amplitude (T tw,pot), high-frequency torque (T 100 Hz) and the low-to-high frequency torque ratio (T 10 Hz /T 100 Hz), i.e., indicators of peripheral fatigue. M-wave-normalized EMG amplitudes (EMG/M) and the maximal voluntary activation level (VA) were calculated to quantify central fatigue. Adults (15.9 ± 3.9 repetitions) performed fewer MVICs than children (40.4 ± 19.7) and endurance athletes (51.7 ± 19.6), however, no difference was observed between children and athletes (P = 0.13). T tw,pot (∼52%, P < 0.001), T 100 Hz (∼39%, P < 0.001) and T 10 Hz /T 100 Hz (∼23%, P < 0.001) decreased only in adults. Similar decrements in vastus medialis and vastus lateralis EMG/M were observed in children and endurance athletes (range: 40-50%), and these were greater than in adults (∼15%). Whilst VA decreased more in children (−38.4 ± 22.5%, P < 0.001) than endurance athletes (−20.3 ± 10.1%, P < 0.001), it did not change in adults. Thus, children fatigued more slowly than adults and as much as endurance athletes. They developed less peripheral and more central fatigue than adults and, although central fatigue appeared somewhat higher in children than endurance athletes, both children and endurance athletes experienced greater decrements than adults. Therefore, children exhibit a more comparable neuromuscular fatigue profile to endurance athletes than adults.
Published: 2019

18. Impact of Vitamin D Supplementation on Influenza Vaccine Response and Immune Functions in Deficient Elderly Persons: A Randomized Placebo-Controlled Trial

Author: Nicolas Goncalves-Mendes, Jérémie Talvas, Christian Dualé, Aline Guttmann, Violaine Corbin, Geoffroy Marceau, Vincent Sapin, Patrick Brachet, Bertrand Evrard, Henri Laurichesse, Marie-Paule Vasson, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), CIC 1405, CIC/Centre de Pharmacologie Clinique, Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand, Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Biostatistiques, Inferential, Maladies infectieuses et tropicales, Biochimie Médicale - Biologie Moleculaire, Immunologie, Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), UNICANCER, Université d'Auvergne (Clermont Ferrand 1) (UdA), Université d'Auvergne - Clermont-Ferrand I (UdA), CHU Gabriel Montpied (CHU), CIC Clermont Ferrand, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre de Pharmacologie Clinique-CHU Gabriel-Montpied, Neuro-Dol (Neuro-Dol), Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Image Science for Interventional Techniques (ISIT), Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université-Centre National de la Recherche Scientifique (CNRS), Laoratoire de Biochimie, Centre Hospitalier Universitaire de Clermont-Ferrand, Laboratoire de Biochimie, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Laboratoire d'Immunologie, Service des Maladies Infectieuses et Tropicales, Hôpital Gabriel Montpied, Clermont-Ferrand, France, Service des Maladies Infectieuses et Tropicales, Hopital Gabriel Montpied, Clermont-Ferrand, France, Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université, Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand-Centre de Pharmacologie Clinique, Université d'Auvergne - Clermont-Ferrand I (UdA)-Centre National de la Recherche Scientifique (CNRS)-Clermont Université, Service d'Immunologie [CHU Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Service des Maladies Infectieuses et Tropicales [CHU Clermont-Ferrand], Centre Hospitalier Universitaire Gabriel Montpied, Université Clermont Auvergne (UCA), Centre Jean Perrin, Dualé, Christian, and Vasson, Marie-Paule
Subjects: Male, 0301 basic medicine, Lymphocyte, chemistry.chemical_compound, 0302 clinical medicine, Transforming Growth Factor beta, Immunologie, cathelicidin, cytokine, randomized trial, Immunology and Allergy, Vitamin D, Th1-Th2 Balance, ComputingMilieux_MISCELLANEOUS, vitamin-D deficiency, influenza vaccination, aging, leukocyte phenotyping, Vaccination, Immunosenescence, Orthomyxoviridae, Clinical Trial, humanities, 3. Good health, medicine.anatomical_structure, Influenza Vaccines, [SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, [SDV.IMM]Life Sciences [q-bio]/Immunology, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Female, lcsh:Immunologic diseases. Allergy, [SDV.SP.MED] Life Sciences [q-bio]/Pharmaceutical sciences/Medication, Influenza vaccine, Immunology, vitamin D deficiency, 03 medical and health sciences, Th2 Cells, Immune system, [SDV.SP.MED]Life Sciences [q-bio]/Pharmaceutical sciences/Medication, Double-Blind Method, Immunity, Influenza, Human, Immune Tolerance, medicine, Humans, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Aged, business.industry, social sciences, biochemical phenomena, metabolism, and nutrition, Th1 Cells, Placebo Effect, Vitamin D Deficiency, medicine.disease, 030104 developmental biology, chemistry, Dietary Supplements, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, lcsh:RC581-607, Cholecalciferol, business, 030215 immunology
Abstract: Background: Immunosenescence contributes to reduced vaccine response in elderly persons, and is worsened by deficiencies in nutrients such as Vitamin (Vit-D). The immune system is a well-known target of Vit-D, which can both potentiate the innate immune response and inhibit the adaptive system, and so modulate vaccination response.Objective: This randomized placebo-controlled double-blind trial investigated whether Vit-D supplementation in deficient elderly persons could improve influenza seroprotection and immune response.Design: Deficient volunteers (Vit-D serum
Published: 2019

19. Effects of a short residential thermal spa program to prevent work-related stress/burnout on stress biomarkers: a proof of concept study

Author: Dutheil, F., Chaplais, Elodie, Vilmant, Audray, Lanoir, Denise, Courteix, Daniel, Duché, Pascal, Abergel, Armand, Pfabigan, Daniela M., Han, Shihui Han, Mondillon, Laurie, Vallet, Guillaume T, Mermillod, Martial, Boudet, Gil, Obert, Philippe, Izem, Omar, Boirie, Yves, Pereira, Bruno, Lesage, François-Xavier, Laboratoire de Psychologie Sociale et Cognitive (LAPSCO), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Centre National de la Recherche Scientifique (CNRS), Service Santé Travail Environnement, CHU Clermont-Ferrand, Australian Catholic University (ACU), Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Département Recherche Clinique et Innovation, Faculty of Health Science, School of Exercise Science, Espace investigation prevention accompagnement du Stress, EIPAS Association, Hépatologie Gastro-Entérologie, CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, PKU-IDG/McGovern Institute For Brain Research, University Beijing, Laboratoire de Psychologie et NeuroCognition (LPNC ), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Univeristé Grenoble Alpes, Faculty of Health, School of Exercise Science, Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), EA4278 Laboratoire de Pharm-Ecologie Cardiovasculaire (LaPEC), Avignon Université (AU), Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Nutrition clinique, CHU Gabriel Montpied [Clermont-Ferrand], Biostatistiques, Danone Research, Dynamique des capacités humaines et des conduites de santé (EPSYLON), Université de Montpellier (UM)-Université Paul-Valéry - Montpellier 3 (UPVM)-Université Montpellier 1 (UM1), Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Université Montpellier 1 (UM1)-Université Paul-Valéry - Montpellier 3 (UPVM)-Université de Montpellier (UM), Laboratoire de Psychologie Sociale et Cognitive - Clermont Auvergne (LAPSCO), Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Université Clermont Auvergne (UCA), Centre Hospitalier Universitaire de Clermont-Ferrand, Australian Catholic University, EA 3533, Laboratoire des Adaptations Métaboliques à l’Exercice en conditions Physiologiques et Pathologiques (AME2P), Centre Hospitalier Universitaire Estaing, UMR 6284, Laboratoire de Psychologie et NeuroCognition (LPNC), laboratoire de Pharm-Ecologie Cardiovasculaire (LaPEC ), Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Centre Hospitalier Universitaire Gabriel Montpied, and Université Montpellier 1 (UM1)-Université Paul-Valéry - Montpellier 3 (UM3)-Université de Montpellier (UM)
Subjects: [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: The study is integrally funded by the Region Auvergne Rhone-Alpes by the University Hospital of Clermont-Ferrand, by the European Regional Development Fund (FEDER, Fonds Europeen de Developpement Economique et Regional) and by the spa resort of Neris-les-Bains. The funding source had no role in the design, conduct, or reporting of the study. The authors wish to thank Ms Frederique BRIAT for her commitment to setting up and monitoring the program. The authors wish also to thank Mr Bertrand BLOYER for promoting a short residential thermal spa program to prevent work-related stress/burnout.; Effects of a short residential thermal spa program to prevent work-related stress/burnout on stress biomarkers: a proof of concept study
Published: 2019

20. Muscle loss associated changes of oxylipin signatures during biological aging: an exploratory study from the PROOF cohort

Author: Alice Decourt, Cécile Coudy-Gandilhon, Annika I. Ostermann, Thade Konrad, Cécile Gladine, Daniel Béchet, Nils Helge Schebb, Céline Dalle, Léonard Féasson, Frédéric Roche, André Mazur, Jean-Claude Barthélémy, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Faculty of Mathematics and Natural Sciences, University of Wuppertal, University of Veterinary Medicine Hanover, Service de Physiologie Clinique et de l'Exercice, Faculté de Médecine Jacques Lisfranc, PRES Université de Lyon, Université Jean Monnet (Saint-Etienne), Université de Lyon, Service de Neurologie, Centre Hospitalier du Pays d'Aix, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), German Resaerch Foundation SCHE 1801Fondation Caisse d'Epargne Rhone-Alpes (CERA) 30French government IDEX-ISITE initiative 16-IDEX-0001 CAP 20-25French Ministry of Health, ProdInra, Archive Ouverte, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Institute for Food Toxicology, University of Veterinary Medicine, Chair of Food Chemistry, Faculty of Mathematics and Natural Sciences, service de chirurgie cardiaque, Centre Hospitalier Universitaire Gabriel Montpied, Service de Physiologie Clinique et de l'Exercice, CHU Nord, Faculté de Médecine Jacques Lisfranc, Unité de Myologie, Centre Référent Maladies Neuromusculaires Rares Rhône-Alpes, Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Institute for Food Toxicology and Analytical Chemistry, University of Veterinary Medicine Hannover, Unité de Myologie, Centre Hospitalier Universitaire de Saint-Etienne, Service de Physiologie Clinique et de l'Exercice [CHU de Saint-Etienne], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM), Université Jean Monnet - Saint-Étienne (UJM), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Université Catholique de Louvain (UCLouvain). BEL., CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Institut Multidisciplinaire de Biochimie des Lipides (IMBL). FRA., Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), ANR-16-IDEX-0001,CAP 20-25,CAP 20-25(2016), Unité de Nutrition Humaine - Clermont Auvergne ( UNH ), Université Clermont Auvergne ( UCA ) -Institut national de la recherche agronomique [Auvergne/Rhône-Alpes] ( INRA Auvergne/Rhône-Alpes ), and Centre Hospitalier Universitaire de Saint-Etienne ( CHU de Saint-Etienne )
Subjects: 0301 basic medicine, Male, Aging, Sarcopenia, [CHIM.ANAL] Chemical Sciences/Analytical chemistry, [ SDV.AEN ] Life Sciences [q-bio]/Food and Nutrition, Lipid mediators, Inflammation, medicine.disease_cause, Bioinformatics, analyse métabolomique, 03 medical and health sciences, 0302 clinical medicine, Metabolomics, Absorptiometry, Photon, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, medicine, Humans, Longitudinal Studies, Oxylipins, Prospective Studies, perte de muscle, Aged, 80 and over, business.industry, Lipid signaling, vieillissement, Oxylipin, medicine.disease, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, 030104 developmental biology, oxylipine, Ageing, ageing, Cohort, Eicosanoids, Female, Geriatrics and Gerontology, medicine.symptom, business, étude de cohorte, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, 030217 neurology & neurosurgery, Oxidative stress, Biomarkers
Abstract: L’Unité de Nutrition Humaine (UNH - Clermont-Ferrand) organise cette année avec l’aide du laboratoire CarMeN (Lyon) la 18ème éditionL’Unité de Nutrition Humaine (UNH - Clermont-Ferrand) organise cette année avec l’aide du laboratoire CarMeN (Lyon) la 18ème édition; Characterizations of the multiple mechanisms determining biological aging are required tobetter understand the etiology and identify early biomarkers of sarcopenia. Oxylipins are a largefamily of signaling lipids involved in the regulation of various biological processes that becomedysregulated during aging.To investigate whether comprehensive oxylipin profiling could provide an integrated and finecharacterisation of the early phases of sarcopenia, we performed a quantitative targetedmetabolomics of oxylipins in plasma of 81-year old subjects from the PROOF cohort withdecreased (n=12), stable (n=16) or increased appendicular muscle mass (n=14).Multivariate and univariate analyses identified significant and concordant changes of oxylipinprofiles according to the muscle status. Of note, 90% of the most discriminant oxylipins werederived from EPA and DHA and were increased in the sarcopenic subjects. The oxylipinssignatures of sarcopenic subjects revealed subtle activation of inflammatory resolutionpathways, coagulation processes and oxidative stress and the inhibition of angiogenesis. Heatmaps highlighted relationships between oxylipins and the cardiometabolic health parameterswhich were mainly lost in sarcopenic subjects.This exploratory study supports that targeted metabolomics of oxylipins could provide relevantand subtle characterization of early disturbances associated with muscle-loss during aging.
Published: 2019

21. BRACAVENIR: an observational study of expectations and coping in young women with high hereditary risk of breast and ovarian cancer

Author: Anne-Sophie Grémeau, Charlotte Chaptal, Marie Beguinot, Céline Verlet, Mathilde Gay-Bellile, Sylvie Jouvency, Claire Laquet, Pascal Dessenne, Yves-Jean Bignon, Marilyn Broult, Marie-Françoise Petit, Fabrice Kwiatkowski, Véronique Boussion, Martine Duclos, Oncogénétique, Institut Curie [Paris]-Hôpital René HUGUENIN (Saint-Cloud), Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Sénologie, Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), UNICANCER-UNICANCER, Chirurgie, CHU Metz-Hôpital Bon Secours, Gynécologie, Accompagnement et soutien, UNICANCER, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Médecine du Sport et des Explorations Fonctionnelles, CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Fondation de l'Avenir et la MASFIP AP-MAS-15-003, Institut Curie-Hôpital René HUGUENIN (Saint-Cloud), Imagerie Moléculaire et Stratégies Théranostiques - Clermont Auvergne (IMoST), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA), Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Centre Hospitalier Universitaire Gabriel Montpied, and Kwiatkowski, F.
Subjects: 0301 basic medicine, Group sharing, Coping (psychology), medicine.medical_specialty, lcsh:QH426-470, endocrine system diseases, Genetic counseling, [SDV.CAN]Life Sciences [q-bio]/Cancer, 030105 genetics & heredity, Oncogenetics, Psychodrama, lcsh:RC254-282, 03 medical and health sciences, Young women, Coping, Hope, Cancer, Oncology, HBOC, 0302 clinical medicine, Medicine, skin and connective tissue diseases, Genetics (clinical), business.industry, Research, Debriefing, BRCA mutation, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Prophylactic Surgery, 3. Good health, lcsh:Genetics, 030220 oncology & carcinogenesis, Family medicine, Anxiety, Observational study, medicine.symptom, business
Abstract: Background In families with high risk of hereditary breast/ovarian cancer (HBOC), women before age 30 do not yet undergo clinical screening, but they are exposed to contradictory information from diverse sources. They may be presented with surgical prevention options at a key moment of their identity construction, the start of a marital relationship and/or at the onset of procreation projects. We tested an original psychoeducational intervention to help these women better cope with these difficult issues. Methods Seven young female counselees (26.4 ± 2.9 years [23–30]) from the Oncogenetics Department at Jean Perrin Comprehensive Cancer Center were enrolled. A weekend group workshop composed of short conferences, group sharing and role playing activities was supervised by a psychotherapist. A longitudinal analysis of questionnaires over one year of follow-up was performed. The Herth Hope Inventory was evaluated, as well as self-esteem, anxiety, perceived control, coping, and quality of life. Participants’ comments were collected by a genetic counselor throughout the workshop. Results All participants were BRCA mutation carriers and six had lived with a close relative affected by breast/ovarian cancer. Hope, self-esteem and quality of life increased during the year after the workshop (p = 0.0003). Coping by focus on the problem increased in the first 6 months (p = 0.011) and returned to baseline values at one year, while coping by focus on emotions decreased steadily (p = 0.021). Debriefing from the workshop highlighted the new medical opportunities proposed and the challenges these young women face, such as whether to have prophylactic surgery, and if so before or after having children, and how surgery might affect their relationship with their partner. Conclusion A tailored two-day psychoeducational workshop may be sufficient to improve the way young women with BRCA mutations deal with the implications of HBOC risk. Trial registration BRACAVENIR was registered in ClinicalTrials.gov with no NCT02705924. Electronic supplementary material The online version of this article (10.1186/s13053-019-0107-7) contains supplementary material, which is available to authorized users.
Published: 2019

22. Whey Protein and Muscle Protection

Author: Yves Boirie, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Nutrition clinique, CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), and Centre Hospitalier Universitaire Gabriel Montpied
Subjects: 2. Zero hunger, chemistry.chemical_classification, 0303 health sciences, Whey protein, Calorie, animal structures, Anabolism, 030309 nutrition & dietetics, Chemistry, digestive, oral, and skin physiology, Skeletal muscle, food and beverages, 030209 endocrinology & metabolism, Metabolism, Amino acid, 03 medical and health sciences, 0302 clinical medicine, Postprandial, medicine.anatomical_structure, fluids and secretions, Biochemistry, medicine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Ingestion, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract: Whey protein is a “fast” digestive milk soluble protein since it is rapidly absorbed and its ingestion can affect whole body and skeletal muscle metabolism through its fast and intense rise in postprandial amino acids availability. So dietary proteins can be characterized as “fast” or “slow” proteins depending on matrix food structure, technological processes, added calories, and their digestive behaviors. Interestingly, despite identical amino acids composition, a fast digestive protein like whey protein can stimulate muscle protein synthesis and improve muscle function in many studies involving older patients. These findings may be applied for improving global health through preservation or restoration of muscle protein mass and function in clinical situations. In addition, anabolic action of whey protein on muscle protein synthesis may be potentiated by other nutrients like vitamin D or omega 3 fatty acids or by combination with exercise. So, beyond the amount of dietary protein which is known to be a major anabolic factor, the “fast” protein concept can be beneficial for muscle protein preservation and represents a promising therapeutic perspective to improve mobility and quality of life during chronic disease.
Published: 2019

23. Health-related quality of life and perceived health status of adolescents with obesity are improved by a 10-month multidisciplinary intervention independently of body composition changes

Author: Khammassi, Marwa, Miguet, Maude, O'Malley, Grace, Fillon, Alicia, Masurier, Julie, Damaso, Ana R., PEIRERA, Bruno, Lambert, Céline, Duclos, Martine, Courteix, Daniel, Boirie, Yves, Thivel, David, Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Research Unit, Sportive Performance and Physical Rehabilitation, High Institute of Sports and Physical Education of, Université de Jendouba (UJ), Faculté des Sciences de Bizerte [Université de Carthage], Université de Carthage - University of Carthage, Université de Carthage, Childhood Obesity Service, Temple Street Children's University Hospital, Division of Population Health Sciences, Royal College of Surgeons in Ireland (RCSI), Centre de SSR Nutrition-Obésité UGECAM, Paulista Medicine School, Universidade Federal de São Paulo, Biostatistiques, Danone Research, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Médecine du Sport et Explorations Fonctionnelles, CHU Clermont-Ferrand, Centre de Recherche en Nutrition Humaine, Nutrition clinique, CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, EA 3533, Laboratoire des Adaptations Métaboliques à l’Exercice en conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne (UCA), Faculté des Sciences de Bizerte, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Centre Hospitalier Universitaire de Clermont-Ferrand, and Centre Hospitalier Universitaire Gabriel Montpied
Subjects: Hrqol, Health perception, Adolescents with obesity, Weight-loss, Multidisciplinary intervention, Body composition, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract: Epub ahead of print; BACKGROUND: Although multidisciplinary weight management interventions have been shown effective in improving body composition and cardio-respiratory fitness, their effects on HRQOL and perceived health status remain uncertain in adolescents with obesity. OBJECTIVE: To assess the impact of a 10-month multidisciplinary weight management intervention on HRQOL and health perception in adolescents with obesity, exploring whether these changes were associated with changes in body weight and body composition. METHODS: Thirty-six adolescents with obesity (28 girls and 8 boys; mean age: 13+/-1.32years) enrolled in a multidisciplinary weight management intervention composed of nutritional counseling, physical activity and health-related therapeutic education. Validated self-report questionnaires were used to assess HRQOL (SF-36) and health perception (HP questionnaire) at baseline (T0) after5 months (T1) and after 10month of intervention (T2). In addition, anthropometric parameters and body composition (DXA) were measuredat T0, T1 and T2. RESULTS: Items of the SF-36 significantly improved at T1 and T2, such as physical functioning(P
Published: 2019

24. Inactive runners or sedentary active individuals?

Author: David Thivel, Martine Duclos, EA 3533, Laboratoire des Adaptations Métaboliques à l’Exercice en conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne (UCA), Centre de Recherche en Nutrition Humaine, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Médecine du Sport et des Explorations Fonctionnelles, Centre Hospitalier Universitaire Gabriel Montpied, Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), CHU Gabriel Montpied [Clermont-Ferrand], and CHU Clermont-Ferrand-CHU Clermont-Ferrand
Subjects: Gerontology, business.industry, Physical Therapy, Sports Therapy and Rehabilitation, 030229 sport sciences, Sedentary behavior, Running, 03 medical and health sciences, 0302 clinical medicine, Humans, Medicine, Orthopedics and Sports Medicine, 030212 general & internal medicine, Sedentary Behavior, business, Recreation, human activities, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: In their recent paper, Rantalainen and collaborators compared the amount and pattern of time spent in moderate-to-vigorous physical activities (MVPA) between habitual recreational runners and seden...
Published: 2019

25. Cognitive restriction accentuates the increased energy intake response to a 10-month multidisciplinary weight loss program in adolescents with obesity

Author: Jean-Philippe Chaput, Bruno Pereira, Michel J. Duclos, Daniel Courteix, David Thivel, Ana Raimunda Dâmaso, Maud Miguet, Céline Lambert, Julie Masurier, Yves Boirie, Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Centre de SSR Nutrition-Obésité UGECAM, Department of Pediatrics, University of Louisville-Kosair Children's Hospital Research Institute, Biostatistiques, Inferential, Paulista Medicine School, Universidade Federal de São Paulo, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Médecine du Sport et Explorations fonctionnelles, CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Centre de Recherche en Nutrition Humaine, Nutrition Clinique, CHU Clermont-Ferrand, Nutrition Obesity Ambulatory Hospital (UGECAM), Auvergne Regional CouncilRegion Auvergne-Rhone-Alpes, EA 3533, Laboratoire des Adaptations Métaboliques à l’Exercice en conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne (UCA), Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Centre Hospitalier Universitaire Gabriel Montpied, and Centre Hospitalier Universitaire de Clermont-Ferrand
Subjects: 0301 basic medicine, Weight loss, Adolescent, media_common.quotation_subject, Psychological intervention, Appetite, 030209 endocrinology & metabolism, Multidisciplinary intervention, 03 medical and health sciences, 0302 clinical medicine, Cognition, Sex Factors, Multidisciplinary approach, Intervention (counseling), Surveys and Questionnaires, Medicine, Humans, General Psychology, media_common, 030109 nutrition & dietetics, Nutrition and Dietetics, Restrained eaters, business.industry, Pediatric obesity, Feeding Behavior, Anthropometry, medicine.disease, Obesity, Weight Reduction Programs, Body Composition, Energy intake, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Basal Metabolism, medicine.symptom, business, Dietary profile, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Demography
Abstract: Epub ahead of print; BACKGROUND: Multidisciplinary interventions have shown some merits in weight reduction strategies in youth, however, their impact on subsequent daily energy intake remains largely unknown. The aim of the present study was to evaluate the nutritional responses to a 10-month multidisciplinary intervention among adolescents with obesity, in relation to their eating behavior characteristics. METHODS: Thirty-five adolescents (mean age: 13.4+/-1.2 years) with obesity took part in a 10-month residential multidisciplinary weight loss program. Anthropometric measurements, body composition (dual-energy X-ray absorptiometry), 24-h ad libitum energy intake (weighted), eating behaviors (Dutch Eating Behavior Questionnaire) and appetite sensations (Visual Analogue Scales) were assessed on three occasions: at their arrival in the institution (T0), after 5 months (T1), and at the end of the 10-month program (T2). RESULTS: The mean weight loss reached 11% of the adolescents' initial body weight, with an important inter-individual variability (-25% to +3% of their initial body weight). Results revealed sex differences change, with boys showing a higher decrease in fat mass percent and increase in fat-free mass compared with girls. Weight loss was accompanied by a significant decrease in emotional (-8.3%, p < 0.05) and external (-14.8%, p < 0.001) eating scores and a significant increase in 24-h ad libitum energy intake (+246 kcal, p < 0.001). The observed subsequent increased 24-h ad libitum energy intake at T2 compared to T0 was significantly higher in cognitively restrained eaters (+492 kcal) compared to unrestrained eaters (+115 kcal, p = 0,015). Dietary restraint score at baseline was inversely correlated with the percentage of weight loss (r = -0.44, p = 0.010). CONCLUSION: A 10-month multidisciplinary weight loss intervention induced an increase in 24-h ad libitum energy intake compared to baseline, especially in cognitively restrained eaters. Moreover, initially cognitively restrained eaters tended to lose less body weight compared to unrestrained ones. These findings suggest that cognitive restriction may be a useful eating behavior characteristic to consider as a screening tool for identifying adverse responders to weight loss interventions in youth.
Published: 2019

26. Eccentric cycling is more efficient in reducing fat mass than concentric cycling in adolescents with obesity

Author: Valérie Julian, Frédéric Costes, David Thivel, Bruno Pereira, Martine Duclos, E. Coudeyre, Maud Miguet, Ruddy Richard, service du sport et explorations fonctionnelles, Centre Hospitalier Universitaire Gabriel Montpied, Unité de nutrition Humaine, Institut National de la Recherche Agronomique (INRA), Université Clermont Auvergne (UCA), Centre de Recherche en Nutrition Humaine, Laboratoire des Adaptations Métaboliques à l’Exercice en conditions Physiologiques et Pathologiques (AME2P), Biostatistiques, Danone Research, Centre Hospitalier Universitaire de Clermont-Ferrand, Médecine physique et réadaptation, CHU Clermont-Ferrand-Hôpital Gabriel-Montpied, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Service Médecine du Sport et Explorations Fonctionnelles [CHU Clermont-Ferrand], CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand-CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand, Centre de Recherche en Nutrition Humaine Auvergne [CHU Clermont-Ferrand] (CRNH A), Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI), CHU Clermont-Ferrand-CHU Clermont-Ferrand, Faculté de Médecine - Clermont-Auvergne (FM - UCA), Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Unité de Biostatistiques [CHU Clermont-Ferrand], Service de Médecine Physique et de Réadaptation [CHU Clermont-Ferrand], CHU Clermont-Ferrand-CHU Louise Michel [Clermont-Ferrand], Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), and CHU Clermont-Ferrand-CHU Gabriel Montpied [Clermont-Ferrand]
Subjects: Male, medicine.medical_specialty, Percentile, Pediatric Obesity, Adolescent, genetic structures, [SDV]Life Sciences [q-bio], Physical Therapy, Sports Therapy and Rehabilitation, Isometric exercise, 030204 cardiovascular system & hematology, Childhood obesity, Quadriceps Muscle, 03 medical and health sciences, 0302 clinical medicine, Insulin resistance, Oxygen Consumption, Internal medicine, medicine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Eccentric, Humans, Orthopedics and Sports Medicine, Muscle Strength, Exercise physiology, Adiposity, exercise physiology, body composition, Anthropometry, business.industry, 030229 sport sciences, Original Articles, medicine.disease, Obesity, eye diseases, Bicycling, Exercise Therapy, stomatognathic diseases, Adipose Tissue, eccentric exercise, Cardiology, Lean body mass, Exercise Test, Original Article, Female, sense organs, Insulin Resistance, business, childhood obesity, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract: International audience; The benefits of eccentric (ECC) training on fat mass (FM) remain underexplored. We hypothesized that in obese adolescents, ECC cycling training is more efficient for decreasing whole-body FM percentage compared to concentric (CON) performed at the same oxygen consumption (VO2). Twenty-four adolescents aged 13.4 +/- 1.3 years (BMI > 90th percentile) were randomized to ECC or CON. They performed three cyclo-ergometer sessions per week (30 min per session) for 12 weeks: two habituation, 5 at 50% VO2peak, and 5 at 70% VO2peak. Anthropometric measurements, body composition, maximal incremental CON tests, strength tests, and blood samples were assessed pre- and post-training. Whole-body FM percentage decreased significantly after compared to pretraining in both groups, though to a larger extent in the ECC group (ECC: -10% vs CON: -4.2%, P < 0.05). Whole-body lean mass (LM) percentage increased significantly in both groups after compared to pretraining, with a greater increase in the ECC group (ECC: 3.8% vs CON: 1.5%, P
Published: 2019

27. About the controversies of the cardioprotective effect of n-3 polyunsaturated fatty acids (PUFAs) between animal studies and clinical meta-analyses: a review with several strategies to enhance the beneficial effects of n-3 PUFAs

Author: Thibault Leger, Kasra Azarnoush, Luc Demaison, Catherine Vergely, Luc Rochette, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), EA 7460, Physiologie et Epidémiologie Cérébro-Cardiovasculaire (PEC2), Université de Bourgogne (UB), Chirurgie Cardiaque, Centre Hospitalier Universitaire Gabriel Montpied, Physiopathologie et épidémiologie cérébro-cardiovasculaire [Dijon] (PEC2), Université de Bourgogne (UB)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, and INRA: 1456A
Subjects: 0301 basic medicine, Cardiotonic Agents, Physiology, 030209 endocrinology & metabolism, Myocardial Reperfusion Injury, Pharmacology, Arrhythmias, Biochemistry, 03 medical and health sciences, Mice, 0302 clinical medicine, Meta-Analysis as Topic, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Fatty Acids, Omega-3, Medicine, Animals, Humans, Survival rate, Beneficial effects, N 3 pufa, ComputingMilieux_MISCELLANEOUS, Cardiac death, chemistry.chemical_classification, Reperfusion arrhythmias, Coronary event, Myocardial tissue, business.industry, Myocardium, food and beverages, Arrhythmias, Cardiac, Heart, General Medicine, 3. Good health, Rats, 030104 developmental biology, chemistry, Infarction, N-3 PUFAs, Animal studies, Cellular damages, business, Anti-Arrhythmia Agents, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Polyunsaturated fatty acid
Abstract: Several meta-analyses describing the effect of n-3 polyunsaturated fatty acids on the survival rate of the victims of an acute coronary event do not clearly support a beneficial impact of these fatty acids. Yet, animal studies consistently show n-3 PUFA-induced protection against ischemia-reperfusion-induced myocardial injuries. The impact on reperfusion arrhythmias of these PUFAs is more controversial. The literature shows the anti-arrhythmic properties of circulating n-3 PUFAs. However, when these fatty acids are incorporated in the cardiac membrane, they protect the myocardial tissue vis a vis cellular damage but they can be either pro- or anti-arrhythmic during reperfusion, depending on the severity of tissue injuries. The latter elements can explain the lack of beneficial effect observed in the meta-analyses, but a proper use of n-3 PUFAs may provide advantages in terms of survival rate. This review discusses the different results obtained in humans and animals and presents several strategies to enhance the beneficial effects of n-3 PUFAs.
Published: 2019

28. High-intensity interval training in overweight and obese children and adolescents: systematic review and meta-analysis

Author: David Thivel, Julien Aucouturier, Bruno Pereira, Brian W. Timmons, Serge Berthoin, Julie Masurier, Martine Duclos, Georges Baquet, UE 3533, Laboratoire des Adaptations Métaboliques à l’Exercice en conditions Physiologiques et Pathologiques (AME2P), Centre Auvergne de l'Obésité et de ses Risques en Santé (CALORIS), Centre Hospitalier Universitaire Gabriel Montpied, Centre de SSR Nutrition-Obésité UGECAM, EA7369, Université Lille 2-Faculté des Sciences du Sport et de l'Education Physique, Department of Pediatrics (DEPARTMENT OF PEDIATRICS), University Clinic Carl Gustav Carus, Dresden, Biostatistique, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Médecine du Sport et des Explorations Fonctionnelles, CRNH Auvergne, CHU, Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand, Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 (URePSSS), Université d'Artois (UA)-Université du Littoral Côte d'Opale (ULCO)-Université de Lille, CHU Fattouma Bourguiba [Monastir] (HFB), Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Université d'Artois (UA)-Université de Lille-Université du Littoral Côte d'Opale (ULCO), Univ. Littoral Côte d’Opale, Univ. Artois, Université de Lille, Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - EA 7369, Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques [AME2P], Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 [URePSSS], McMaster University [Hamilton, Ontario], and Université de Clermont-Ferrand
Subjects: Male, medicine.medical_specialty, Adolescent, Physical fitness, 030209 endocrinology & metabolism, Physical Therapy, Sports Therapy and Rehabilitation, Overweight, High-intensity interval training, Child, 03 medical and health sciences, Oxygen Consumption, 0302 clinical medicine, Insulin resistance, Metabolic Diseases, Risk Factors, Internal medicine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, Medicine, Aerobic exercise, Orthopedics and Sports Medicine, Obesity, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, business.industry, VO2 max, 030229 sport sciences, medicine.disease, 3. Good health, Blood pressure, Meta-analysis, Female, medicine.symptom, business
Abstract: INTRODUCTION: While High Intensity Interval Training is praised in many populations for its beneficial effects on body composition and cardiometabolic health, its use among obese youth remain uncertain. This study aimed at determining whether HIIT is effective to improve aerobic fitness and reduce cardiometabolic risk factors in overweight and obese youth. EVIDENCE ACQUISITION: A systematic search was conducted and articles reporting studies that investigated the effects of HIIT in 6 to 18-year-old youth were eligible. Meta-analyses were performed when appropriate. EVIDENCE SYNTHESIS: Fifteen studies were included for the systematic review and meta-analyses. HIIT significantly improves maximal oxygen uptake (1.117 [95% CI: 0.528 to 1.706], P
Published: 2019

29. Introducing eccentric cycling during a multidisciplinary weight loss intervention might prevent adolescents with obesity from increasing their food intake: the TEXTOO study

Author: Bruno Pereira, Maud Miguet, Kristine Beaulieu, Valérie Julian, Richard Richard, Graham Finlayson, Martine Duclos, David Thivel, EA 3533, Laboratoire des Adaptations Métaboliques à l’Exercice en conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne (UCA), CRNH Auvergne, Faculty of Medicine and Health, University of Leeds, Médecine du sport et Explorations fonctionnelles, CHU Gabriel Montpied [Clermont-Ferrand], Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Biostatistiques (DRCI), CHU Clermont-Ferrand, Médecine du sport et explorations fonctionnelles, Centre Hospitalier Universitaire Gabriel Montpied, Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), CHU Clermont-Ferrand-CHU Clermont-Ferrand, Unité de Nutrition Humaine (UNH), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre de Recherche en Nutrition Humaine Auvergne [CHU Clermont-Ferrand] (CRNH A), and Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI)
Subjects: Male, medicine.medical_specialty, Adolescent, Eccentric cycling, 030309 nutrition & dietetics, media_common.quotation_subject, Appetite, 030209 endocrinology & metabolism, Experimental and Cognitive Psychology, Eating, 03 medical and health sciences, Behavioral Neuroscience, Reward system, 0302 clinical medicine, Weight loss, Intervention (counseling), medicine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, Eccentric, Obesity, Child, Exercise, media_common, 2. Zero hunger, 0303 health sciences, business.industry, Food reward, Pediatric obesity, Anthropometry, medicine.disease, Bicycling, Weight Reduction Programs, Adolescent Behavior, Physical therapy, Female, Energy intake, medicine.symptom, Cycling, business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract: The present study compared the appetite responses to an inpatient eccentric vs. concentric cycling training programs in adolescents with obesity.24 adolescents with obesity (12-16yrs; Tanner 3-4) followed a 12-week multidisciplinary intervention (Phase1), after which they were randomized to concentric (CON) or eccentric (ECC) training for 12 weeks (Phase2). Assessment of anthropometrics, body composition (DXA), aerobic power (VOBody mass, BMI, and fat mass (FM%) decreased in both groups (p 0.001). FM% reduction was greater in ECC at T2 (-9.9%). EI did not change in either group at T1, but was greater at T2 relative to T1 in CON only (p 0.001,+22%). There was no correlation between the change in body mass, FM%, fat-free mass and EI. Hunger (p = 0.002) and desire to eat (p = 0.001) were higher in CON vs. ECC with no time effects nor interactions. Prospective food consumption increased in both groups with no group effect nor interaction. Satiety was not different between groups or over time. In ECC, preference for high-fat foods increased (p = 0.03), and preference (p = 0.004) and implicit wanting (p = 0.016) for sweet foods decreased.Eccentric cycling as part of an inpatient multidisciplinary weight-loss intervention might help prevent increased ad libitum energy intake compared to concentric exercise training in adolescents with obesity, potentially through distinct effects of the food reward system.
Published: 2019

30. Satiety responsiveness but not food reward is modified in response to an acute bout of low versus high intensity exercise in healthy adults

Author: Maud Miguet, Yves Boirie, Marie-Eve Mathieu, P. M. Genin, Marwa Khammassi, Graham Finlayson, André J. Tremblay, John E. Blundell, Alicia Fillon, Martine Duclos, Lore Metz, B. Pereira, Vicky Drapeau, David Thivel, EA 3533, Laboratoire des Adaptations Métaboliques à l’Exercice en conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne (UCA), Appetite Control and Energy Balance Research Group, University of Leeds, Centre de SSR Nutrition-Obésité UGECAM, DRCI, Biostatistiques, CHU Clermont-Ferrand, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Nutrition clinique, Centre Hospitalier Universitaire Gabriel Montpied, CRNH Auvergne, Médecine du sport et exploration fonctionnelle, CHU Gabriel Montpied [Clermont-Ferrand], Institute of Nutrition and Functional Foods INAF, Université Laval, School of kinesiology and Physical Activity Sciences, Université de Montréal (UdeM), Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), CHU Clermont-Ferrand-CHU Clermont-Ferrand, Centre de Recherche en Nutrition Humaine Auvergne [CHU Clermont-Ferrand] (CRNH A), Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI), Unité de Nutrition Humaine (UNH), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and National French University Institute (IUF)
Subjects: Male, 0301 basic medicine, medicine.medical_specialty, Intensity, media_common.quotation_subject, Appetite, 030209 endocrinology & metabolism, Satiation, Affect (psychology), Food Preferences, Young Adult, 03 medical and health sciences, Oxygen Consumption, 0302 clinical medicine, Reward, Satiety quotient, Surveys and Questionnaires, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, Medicine, Young adult, Exercise, General Psychology, Aerobic capacity, media_common, 2. Zero hunger, Meal, 030109 nutrition & dietetics, Nutrition and Dietetics, business.industry, digestive, oral, and skin physiology, Food reward, VO2 max, Anthropometry, Food, Body Composition, Physical therapy, Female, Energy Intake, business, human activities, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Body mass index
Abstract: To compare the effect of iso-caloric low and high intensity exercises on Satiety Quotient and Food Reward in response to a fixed meal in healthy young adults. Anthropometric measurements, body composition (BIA), aerobic capacity (VO2 max) and food preferences were assessed in 19 healthy normal-weight young adults (21 +/- 0.5 years old, 10 men). They randomly completed 3 experimental sessions: i) control session without exercise (CON); ii) High Intensity exercise session (HIE); iii) Low intensity exercise session (LIE). Thirty minutes after exercise or rest, then received a fixed lunch. Food reward (Leeds Food Preference Questionnaire) was assessed before and after the meal. Appetite sensations were assessed at regular intervals, SQ was calculated from the lunch meal and self-reported food intake was collected for the rest of the day. Mean body weight was 66.7 +/- 9.2 kg, body mass index was 22.3 +/- 2.9 kg/m2 and FM% was 18.7 +/- 6.8%. Appetite feelings did not differ between conditions and were not affected by exercise. SQ for satiety was not different between conditions. SQ hunger on CON was significantly higher than on LIE and HIE (p= 0.05) with no difference between exercise conditions. SQ for desire to eat was significantly higher on CON versus HIE (p= 0.01) with no differences between CON and LIE and between exercise sessions. SQ PFC was significantly lower on HIE compared with CON (p= 0.02) with no differences between LIE and CON and between LIE and HIE. Food reward was not significantly different between the three condition as well as self-reported total food and macronutrient intake for the rest of the days. Acute exercise, depending on its intensity, might affect the satiating response to food intake in healthy adults, without altering food reward.
Published: 2020

31. Effect of Work-Related Sedentary Time on Overall Health Profile in Active vs. Inactive Office Workers

Author: Pauline M. Genin, Pascal Dessenne, Julien Finaud, Bruno Pereira, Frederic Dutheil, David Thivel, Martine Duclos, Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Centre de Recherche en Nutrition Humaine, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), UFR Medicine, Université d'Auvergne - Clermont-Ferrand I (UdA), Caisse Primaire Assurance Maladie (CAPM), Association Sportive Montferrandaise, Biostatistiques, Inferential, CHU Clermont-Ferrand, School of Exercise Science, Australian Catholic University (ACU), CHU Gabriel Montpied [Clermont-Ferrand], Médecine du sport et explorations fonctionnelles, CHU Clermont-Ferrand-CHU Clermont-Ferrand, Genin, Pauline M., Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques - Clermont Auvergne (AME2P), Faculté des Sciences du SportFaculté des Sciences du Sport, UFR STAPS-Université Clermont Auvergne (UCA), Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Université d'Auvergne (Clermont Ferrand 1) (UdA), Centre Hospitalier Universitaire de Clermont-Ferrand, Australian Catholic University, and Centre Hospitalier Universitaire Gabriel Montpied
Subjects: medicine.medical_specialty, Physical fitness, physical activity, Sitting, Work related, 03 medical and health sciences, Screen time, 0302 clinical medicine, Quality of life, tertiary employees, health, fitness, sedentariness, medicine, 030212 general & internal medicine, Original Research, business.industry, lcsh:Public aspects of medicine, Public health, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, Cardiorespiratory fitness, 030229 sport sciences, Anthropometry, 3. Good health, Santé publique et épidémiologie, 8. Economic growth, Physical therapy, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Public Health, business
Abstract: Objective: While public health strategies are developed to fight sedentary behaviors and promote physical activity, some professional activities, and especially tertiary ones, have been pointed out for their highly sedentary nature. Although workplace physical activity programs are increasingly proposed by companies to their employees in order to increase their physical activity levels, sitting and screen time remain extremely high. The main aim of this work was to compare health indicators between active and inactive tertiary employees with similar high levels of sedentariness. Secondly, we questioned the effects of a 5-month workplace physical activity program on overall health indicators among initially active and inactive tertiary employees.Methods: Anthropometric measurements, body composition (bio-impedance), physical fitness (cardiorespiratory and musculoskeletal fitness) and health-related quality of life and perception of health status (self-reported questionnaires) were assessed among 193 active and inactive tertiary employees before (T0) and after a 5-month workplace physical activity intervention (T1), composed of 2 physical sessions per week.Results: Significant improvements were found in performance of push-ups (p < 0.001), back muscle strength (p < 0.001) fat mass (p < 0.01) and waist circumference (p < 0.05) in active compared with inactive employees both at baseline and at the end of the program. Health perception (p < 0.001) was significantly different between groups at T0 but not at T1. However, no significant difference was observed for fat-free mass, BMI, workplace well-being and lower and upper limbs muscle strength. The variations between T0 and T1 demonstrate that, while all the studied parameters progressed positively during the 5-month program, health perception (p < 0.001), back muscle strength (p < 0.05) and BMI (tendency) showed a significantly higher progression in the inactive compared with the active group.Conclusion: Health indicators might not be improved among active tertiary employees compared with inactive ones, which might be due to the high level of sedentariness characterizing their occupational task.Structured on-site physical activity programs can improve health in both initially active and inactive employees.
Published: 2018

32. Eccentric Training Improves Body Composition by Inducing Mechanical and Metabolic Adaptations: A Promising Approach for Overweight and Obese Individuals

Author: Valérie Julian, Frédéric Costes, Bruno Pereira, Ruddy Richard, Martine Duclos, Hélène Perrault, David Thivel, Julianne Touron, Yves Boirie, service du sport et explorations fonctionnelles, Centre Hospitalier Universitaire Gabriel Montpied, Unité de nutrition Humaine, Institut National de la Recherche Agronomique (INRA), Université Clermont Auvergne (UCA), Centre de Recherche en Nutrition Humaine, Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques - Clermont Auvergne (AME2P), Faculté des Sciences du SportFaculté des Sciences du Sport, UFR STAPS-Université Clermont Auvergne (UCA), Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), service de nutrition clinique, Centre Hospitalier Universitaire de Clermont-Ferrand, Biostatistiques, Inferential, Faculté des sciences de la santé, University of Ottawa [Ottawa] (uOttawa), CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), CHU Clermont-Ferrand, University of Ottawa [Ottawa], Service Médecine du Sport et Explorations Fonctionnelles [CHU Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand-CHU Estaing [Clermont-Ferrand], Université Clermont Auvergne (UCA)-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Centre de Recherche en Nutrition Humaine Auvergne [CHU Clermont-Ferrand] (CRNH A), Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI), Service de Nutrition Clinique [CHU Clermont-Ferrand], Unité de Biostatistiques [CHU Clermont-Ferrand], and Université d'Ottawa [Ontario] (uOttawa)
Subjects: obesity, medicine.medical_specialty, eccentric exercise, fat mass, concentric exercise, lean mass, metabolism, training effects, genetic structures, Physiology, [SDV]Life Sciences [q-bio], Review, Overweight, lcsh:Physiology, 03 medical and health sciences, 0302 clinical medicine, Insulin resistance, Physical medicine and rehabilitation, Physiology (medical), [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], medicine, Food and Nutrition, Eccentric, Resting energy expenditure, Physiologie, ComputingMilieux_MISCELLANEOUS, lcsh:QP1-981, business.industry, Work (physics), 030229 sport sciences, medicine.disease, Obesity, eye diseases, stomatognathic diseases, Alimentation et Nutrition, Eccentric training, Lean body mass, sense organs, medicine.symptom, business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, 030217 neurology & neurosurgery
Abstract: Skeletal muscle generates force by either shortening (concentrically) or lengthening (eccentrically). Eccentric (ECC) exercise is characterized by a lower metabolic demand and requires less muscle activity than concentric (CON) exercise at the same level of exerted force. However, the specific effect of ECC training vs. CON training on lean and fat mass remains underexplored. The first aim of this paper was to review the available evidence regarding the effects of ECC training on whole body and segmental lean and fat mass and, when possible, compare these with the effects of CON training. The second aim was to provide some insights into the main mechanical, physiological, and metabolic adaptations of ECC training that contribute to its effects on body composition. The third aim was to determine the beneficial effects of ECC exercise on health-related parameters in overweight and obese patients. ECC training is an effective modality to improve lean mass, but when matched for load or work, the difference between ECC and CON trainings seems unclear. A few studies reported that ECC training is also efficient at reducing fat mass. By increasing post-exercise resting energy expenditure, modifying metabolic substrate, and improving both blood lipid profile and insulin resistance, ECC training is a potential exercise modality for individuals with chronic conditions such as those who are overweight and obese. Further investigations using standardized experimental conditions, examining not only segmental but also whole body composition, are required to compare ECC and CON trainings.
Published: 2018

33. Chronic Pain Opioid-Maintained Patients Receive Less Analgesic Opioid Prescriptions

Author: Jessica Delorme, Chouki Chenaf, Celian Bertin, Marie Riquelme, Alain Eschalier, Denis Ardid, Nicolas Authier, Neuro-Dol - Clermont Auvergne (Neuro-Dol), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA), Pôle de biologie médicale et d'anatomie pathologique, Centre Hospitalier Universitaire Gabriel Montpied, Unité Mixte de Recherches sur les Herbivores - UMR 1213 (UMRH), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Recherche Agronomique (INRA), Pharmacologie fondamentale et clinique de la douleur, Neuro-Dol (Neuro-Dol), Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, and Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: medicine.medical_specialty, lcsh:RC435-571, opioid-maintained patients, [SDV]Life Sciences [q-bio], Population, Analgesic, methadone, opioid analgesics, 03 medical and health sciences, 0302 clinical medicine, lcsh:Psychiatry, Internal medicine, medicine, 030212 general & internal medicine, education, ComputingMilieux_MISCELLANEOUS, Original Research, Psychiatry, education.field_of_study, business.industry, fungi, Chronic pain, Opioid use disorder, Odds ratio, chronic non-cancer pain, buprenorphine, medicine.disease, 3. Good health, Psychiatry and Mental health, Opioid, business, 030217 neurology & neurosurgery, Methadone, medicine.drug, Buprenorphine
Abstract: Treating pain and opioid use disorder represents a clinical challenge. While most studies that have assessed opioid analgesic use in opioid substitution treatment (OST) patients primarily address opioid analgesic misuse (Brands et al., 2004; Rosenblum et al., 2007), only few studies focused on OST patients assessed the prescription of analgesic opioids for chronic pain. We sought to compare the prevalence of analgesic opioid prescription (AOP) in two groups of chronic non-cancer pain (CNCP) patients: OST patients versus the general population. This was a population-based cross-sectional study based on the French national healthcare claims database SNIIRAM (Systeme National d’Informations Inter-Regimes de l’Assurance Maladie) covering over 66 million people (98,8% of the French population). Overall, 67,173 participants ≥15 years old undergoing continuous OST in 2015 (“OST patients” group) were included and age- and gender-matched by means of a 1:1 ratio with 67,173 patients without OST (“control” group). In each group, patients with cancer conditions were excluded and those having received opioid and non-opioid analgesics for at least 3 months were identified (CNCP patients). Compared to control patients, CNCP OST patients received less AOP (47.8% vs. 68.0%, p
Published: 2018

34. Muscle lipotoxicity on sarcopenia development in a model of collagen-induced arthritis

Author: Vial, G., Pinel, Alexandre, Béchet, Daniel, Wauquier, Fabien, Wittrant, Yohann, Chevenet, C., Soubrier, M, Tournadre, A., Capel, Frédéric, Service : Rhumatologie, CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Service d'Anatomie et Cytologie Pathologiques, CHU Amiens-Picardie, European League Against Rheumatism, Centre Hospitalier Universitaire Gabriel Montpied, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Unité de Nutrition Humaine 1019, and Institut National de la Recherche Agronomique (INRA)
Subjects: musculoskeletal diseases, education, musculoskeletal system, human activities, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Web of Science Categories:RheumatologyWeb of Science Categories:Rheumatology; Muscle lipotoxicity on sarcopenia development in a model of collagen-induced arthritis. Congress of the European-League-Against-Rheumatism (EULAR)
Published: 2018

35. Integrating sedentary behavior in the theoretical model linking childhood to adulthood activity and health? An updated framework

Author: Jean-Philippe Chaput, David Thivel, Martine Duclos, Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Université Blaise Pascal - Clermont-Ferrand 2 (UBP), Centre de Recherche en Nutrition Humaine, Children's Hospital of Eastern Ontario Research Institute, University of Ottawa [Ottawa], Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Médecine du Sport et Explorations fonctionnelles, CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques - Clermont Auvergne (AME2P), Faculté des Sciences du SportFaculté des Sciences du Sport, UFR STAPS-Université Clermont Auvergne (UCA), Université Blaise Pascal (Clermont Ferrand 2) (UBP), University of Ottawa [Ottawa] (uOttawa), Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), and Centre Hospitalier Universitaire Gabriel Montpied
Subjects: Pediatric, Adult, Physical activity, Health Status, 030209 endocrinology & metabolism, Experimental and Cognitive Psychology, Sedentary behavior, Models, Theoretical, Sedentary behaviors, Developmental psychology, 03 medical and health sciences, Behavioral Neuroscience, 0302 clinical medicine, Health, Humans, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, 030212 general & internal medicine, Sedentary Behavior, Psychology, Child, Exercise, Adult health
Abstract: About 30 years ago, Blair and collaborators proposed a theoretical model illustrating the relationships between childhood and adulthood physical activity and health. The evolution of our societies has led to a “sedentarisation” of the subsequent generations, and the literature underlines an independent effect of physical activity and sedentary behaviors on health. We propose here an updated version of the model first designed by Blair and colleagues, suggesting the integration of the impact of sedentary behaviors on children and adult health.
Published: 2018

36. Effets de l’acide eicosapentaénoïque et/ou d’un extrait de thé vert sur la fonction cardiaque dans un modèle murin de diabète de type 2

Author: Léger, Thibault, He, Beibei, Rigaudière, Jean-Paul, Azarnousch, Kasra, Demaison, Luc, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), service de chirurgie cardiaque, CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, frederic.capel@inra.fr, Institut Multidisciplinaire de Biochimie des Lipides (IMBL). FRA., Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), and Centre Hospitalier Universitaire Gabriel Montpied
Subjects: [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract: L’Unité de Nutrition Humaine (UNH - Clermont) organise cette année avec l’aide du laboratoire CarMeN (Lyon) la 18ème édition L’Unité de Nutrition Humaine (UNH - Clermont) organise cette année avec l’aide du laboratoire CarMeN (Lyon) la 18ème éditionL’Unité de Nutrition Humaine (UNH - Clermont) organise cette année avec l’aide du laboratoire CarMeN (Lyon) la 18ème édition; Introduction et but de l’étude : L’insuffisance cardiaque représente 65% de la mortalité dans le diabète de type 2. Les effets cardioprotecteurs de l’acide eicosapentaénoïque (EPA) et du thé vert (TV) ont été constatés en cas d’atteintes cardiovasculaires. L’objectif de cette étude était d’évaluer leur impact sur la fonction cardiaque dans le diabète de type 2 (DT2).Matériel et méthodes :Pour cela, 50 rats mâles Wistar étaient répartis en groupes identiques en nombre selon le régime suivi pendant 9 semaines. Le groupe contrôle a été nourri avec des croquettes normolipidiques (3%). Les autres animaux ont suivi une alimentation riche en graisses saturés (HF, 35,2% de lipides) et ont été divisés en 4 groupes : i) HF ; ii) HF + EPA (1,2% du régime) ; iii) HF + extrait de TV (0,5% du régime) ; iv) HF + EPA + extrait de TV(respectivement 1,2% et 0,5% du régime). Après 21 jours, ces derniers ont subi une injection de streptozotocine (STZ, 33 mg/kg) dans le but de déclencher un DT2 en association avec le régime HF. A la fin de la période de régime, la fonction cardiaque a été évaluée ex vivo par la méthode du cœur isolé de Langendorff. Immédiatement après, les mitochondries cardiaques ont été extraites afin d’étudier l’oxydation phosphorylante mitochondriale.Résultats :Les groupes injectés avec la STZ ont présenté une chute de l’insulinémie (-54%, p < 0,05) et une hausse ≥ 3 g/L de la glycémie (p < 0,001). Une réduction de la survie des animaux diabétiques a été constatée, en particulier chez les animaux du groupe HF + EPA (p < 0,05). Après la période de régime, le groupe HF a montré une forte tendance à la baisse de la contractilité cardiaque (-38%, NS) et une chute significative de la réactivité coronaire (-77%, p < 0,001) par rapport au groupe contrôle. L’ajout d’extrait de TV mais aussi d’EPA + extrait deTV dans les régimes HF ont permis de limiter ces altérations par rapport aux rats HF (respectivement : +35% NS et +30%, NS pour la contractilité cardiaque ; +55%, NS et +150%, p < 0,001 pour la réactivité coronaire). L’oxydation phosphorylante mitochondriale a été réduite par le DT2 pour les substrats des complexes I et II (-39% et -27%, p < 0,05), sans différence significative entre les différents régimes HF.Conclusion : Les effets délétères du DT2 sur la fonction cardiaque et l’impact létal de l’EPA sur les rats diabétiques sont partiellement limités grâce à l’extrait de TV. Des analyses complémentaires sont nécessaires pour évaluer l’étiologie de ces observations.
Published: 2018

37. Les fibres alimentaires modifient l’impact de la suralimentationsur le métabolisme hépathique

Author: Mohamed, Ahmed Ben, Remond, Didier, Chambon, Christophe, Sayd, Thierry, Hébraud, Michel, Della Valle, Guy, Capel, Frédéric, Cohade, Benoit, Bechet, Daniel, Coudy-Gandilhon, Cécile, David, Jérémie, Dardevet, Dominique, Dore, Joel, Polakof, Sergio, Savary-Auzeloux, Isabelle, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Qualité des Produits Animaux (QuaPA), Institut National de la Recherche Agronomique (INRA), service de chirurgie cardiaque, Centre Hospitalier Universitaire Gabriel Montpied, Microbiologie Environnement Digestif Santé - Clermont Auvergne (MEDIS), Université Clermont Auvergne (UCA)-INRA Clermont-Ferrand-Theix, Unité de recherche sur les Biopolymères, Interactions Assemblages (BIA), MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Microbiologie Environnement Digestif Santé (MEDIS), Institut Multidisciplinaire de Biochimie des Lipides (IMBL). FRA., INRA Clermont-Ferrand-Theix-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Unité de Nutrition Humaine - Clermont Auvergne ( UNH ), Université Clermont Auvergne ( UCA ) -Institut national de la recherche agronomique [Auvergne/Rhône-Alpes] ( INRA Auvergne/Rhône-Alpes ), Qualité des Produits Animaux ( QUAPA ), Institut National de la Recherche Agronomique ( INRA ), Microbiologie Environnement Digestif Santé - Clermont Auvergne ( MEDIS ), INRA Clermont-Ferrand-Theix-Université Clermont Auvergne ( UCA ), Unité de recherche sur les Biopolymères, Interactions Assemblages ( BIA ), MICrobiologie de l'ALImentation au Service de la Santé humaine ( MICALIS ), and Institut National de la Recherche Agronomique ( INRA ) -AgroParisTech
Subjects: overnutrition, mini porc, [ SDV.AEN ] Life Sciences [q-bio]/Food and Nutrition, dietary fibre, suralimentation, fibre alimentaire, supplémentation alimentaire, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, métabolisme hépatique
Abstract: L’Unité de Nutrition Humaine (UNH - Clermont) organise cette année avec l’aide du laboratoire CarMeN (Lyon) la 18ème éditionL’Unité de Nutrition Humaine (UNH - Clermont) organise cette année avec l’aide du laboratoire CarMeN (Lyon) la 18ème édition; Aim/hypothesis- : Notre étude vise à déterminer si et comment, en situation de surnutrition, lesfibres alimentaires peuvent limiter ou stopper l’apparition des dérégulations métaboliquesassociées à l’ingestion d’un régime obésogène et notamment à limiter l’infiltration lipidiquedans le foie.Research design andMethods :Vingtmini-porcs femelles ont été nourris avec un régime contrôle(C, n=6) (énergie ingérée correspondant aux besoins d’entretien), un régime en surnutritionsupplémenté en pain enrichi (O+F, n=7) ou non (O, n=7) en fibres (pectine, inuline, amidonrésistant). Des prélèvements sanguins ont été réalisés à jeun avant et après 14 et 56 jours derégime O ou O+F, ainsi que le prélèvement d’une section de foie à l’euthanasie. Des analysesde paramètres plasmatiques et hépatiques (protéomique, transcriptomique et histologique : redoil) ont été effectuées. Les effets régimes/cinétiques ont été évaluées par ANOVA un facteur(mesures dans le foie) ou deux facteurs à mesures répétées (mesures en cinétique), significationP
Published: 2018

38. Influence of dietary eicosapentaenoic acid on the cardiac mechanical and mitochondrial functions during early sepsis

Author: Luc Demaison, Thibault Leger, Jean-Paul Rigaudière, Kasra Azarnoush, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), service de chirurgie cardiaque, CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), and Centre Hospitalier Universitaire Gabriel Montpied
Subjects: medicine.medical_specialty, Oxidative phosphorylation, heart, Mitochondrion, Sepsis, sepsis, icosapentaenoic acid, In vivo, Internal medicine, Medicine, 2. Zero hunger, chemistry.chemical_classification, acide eicosapentaénoique, business.industry, fonction mitochondriale, medicine.disease, Eicosapentaenoic acid, Endocrinology, cœur, chemistry, Heart failure, lipids (amino acids, peptides, and proteins), acide gras polyinsaturé n-3, Cardiology and Cardiovascular Medicine, business, Ligation, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Polyunsaturated fatty acid
Abstract: Topic 1 — Inflammation — A Topic 1 — Inflammation — ATopic 1 — Inflammation — A; IntroductionSepsis triggers the failure of cardiac mitochondria and this deleterious effect could be prevented by omega-3 polyunsaturated fatty acids (PUFA).ObjectivesTo evaluate the influence of eicosapentaenoic acid (C20: 5 omega-3 or EPA) on the mechanical and mitochondrial functions of the heart during early sepsis.MethodsFour month-old female Wistar rats were subdivided in 4 groups (n = 8 per group) according to: (i) the 4-week diet given (deficient in omega-3 PUFA [DEF] or enriched with EPA); (ii) the surgery performed (caecal ligation at 1 cm of the apex of the heart and puncture in order to induce sepsis [CLP] or sham). The cardiac mechanical function was studied in vivo by NMR 48 h after the surgery. Immediately after, part of the myocardium was used in order to extract mitochondria and another part was frozen in order to subsequently analyse the fatty acid composition of cardiac phospholipids.ResultsThe EPA groups display a large decrease in the omega-6/omega-3 PUFA ratio of cardiac phospholipids. Sepsis increases the mRNA expression of IL-1beta in the DEF group but not in the EPA one. The mechanical function is altered neither by the diets nor by the surgeries. The DEF/CLP animals have a deficient oxidative phosphorylation compared to the DEF/Sham rats: reduced mitochondrial oxygen consumption (−42%, P < 0.001) and ATP production (−37%, P < 0.05). The sepsis-induced mitochondrial damages in this group is due to an increase reactive oxygen species (ROS) release (+130 and +63% for the ROS/respiration and ROS/ATP ratios, P < 0.01 and P < 0.05, respectively). The dietary EPA prevents these damages (P < 0.05).ConclusionA sufficient EPA intake favours the upholding of the mitochondrial function during early sepsis, which could delay the subsequent development of heart failure. We plan to verify this beneficial effect of EPA in Humans affected by acute endocarditis.
Published: 2018

39. Maladies cardiovasculaires et acide -linolénique : comparaison avec les acides gras polyinsaturés n-3 à longue chaîne

Author: Léger, Thibault, AZARNOUSH, Kasra, Vergeley, Catherine, Rochette, Luc, Demaison, Luc, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Chirurgie Cardiaque, Centre Hospitalier Universitaire Gabriel Montpied, Physiopathologie et épidémiologie cérébro-cardiovasculaire [Dijon] (PEC2), Université de Bourgogne (UB)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Université de Bourgogne (UB), Unité de Nutrition Humaine - Clermont Auvergne ( UNH ), Université Clermont Auvergne ( UCA ) -Institut national de la recherche agronomique [Auvergne/Rhône-Alpes] ( INRA Auvergne/Rhône-Alpes ), Physiopathologie et épidémiologie cérébro-cardiovasculaire [Dijon] ( PEC2 ), Université de Bourgogne ( UB ) -Université Bourgogne Franche-Comté ( UBFC ), Université de Bourgogne ( UB ), Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), CHU Gabriel Montpied [Clermont-Ferrand], and CHU Clermont-Ferrand-CHU Clermont-Ferrand
Subjects: cœur isolé, cardiovascular disease, [ SDV.AEN ] Life Sciences [q-bio]/Food and Nutrition, maladie cardiovasculaire, acide gras polyinsaturé n-3, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, effet protecteur, reperfusion
Abstract: Maladies cardiovasculaires et acide -linolénique : comparaison avec les acides gras polyinsaturés n-3 à longue chaîne
Published: 2018

40. Single Bout Exercise in Children with Juvenile Idiopathic Arthritis: Impact on Inflammatory Markers (vol 2018, 9365745, 2018)

Author: Rochette, Emmanuelle, Duché, Pascale, Hourdé, Christophe, Evrard, Bertrand, Pereira, Bruno, Echaubard, Stéphane, Merlin, Etienne, Pédiatrie Générale Multidisciplinaire, Centre Hospitalier Universitaire Estaing, Unité CRECHE, Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d’Investigation Clinique (CIC), Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques - Clermont Auvergne (AME2P), Faculté des Sciences du SportFaculté des Sciences du Sport, UFR STAPS-Université Clermont Auvergne (UCA), Centre de Recherche en Nutrition Humaine, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Service d’Immunologie, Centre Hospitalier Universitaire Gabriel Montpied, Délégation de la Recherche Clinique et Innovations, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand University Hospital (AOI 2015), CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), CHU Gabriel Montpied [Clermont-Ferrand], and CHU Clermont-Ferrand
Subjects: marker, juvénile, physical exercise, [SDV.IMM]Life Sciences [q-bio]/Immunology, arthrite, marqueur, maladie inflammatoire, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, inflammatory disease, activité physique
Abstract: Corrigendum to "Single Bout Exercise in Children with Juvenile Idiopathic Arthritis: Impact on Inflammatory Markers" DOI: 10.1155/2018/9365745; PubMed ID: 30008613; WOS:000436285900001 In the article titled “Single Bout Exercise in Children with Juvenile Idiopathic Arthritis: Impact on Inflammatory Markers” [1], the first and last names of all the authors were reversed. The revised authors’ list is shown above.; Objective. In a context of inflammatory disease such as juvenile idiopathic arthritis (JIA), we do not know what impact physical activity may have on a deregulated immune system. The objective is to measure the impact of a single bout of exercise on plasma inflammatory markers such as calprotectin, IL-6, sIL-6R, sgp130, and the hypothalamic-pituitary-adrenal axis in children with juvenile idiopathic arthritis. Methods. Twelve children with JIA performed a nonexercise control day and a consecutive day that included a 20 min exercise bout at 70% of max-HR at 08:30 am. Venous blood samples were taken at 08:30, 08:50, 09:30, 10:30 am, and 12:00 pm to measure plasma concentrations of calprotectin, IL-6, sIL-6R, sgp130, cortisol, and ACTH. Pain was evaluated at 08:30, 08:50 am, and 06:00 pm. Results. There was a transient twofold increase in postexercise self-evaluated pain () that disappeared in the evening. A single bout of exercise resulted in a 1.7-fold increase in plasma calprotectin () but not IL-6 and its soluble receptors. Calprotectin levels returned to baseline within 3 hours after cessation of exercise. Conclusion. Acute exercise in children with JIA induced slightly musculoskeletal leg pain and transient increased plasma calprotectin levels but not IL-6 levels.
Published: 2018

41. Employees’ adherence to worksite physical activity programs: Profiles of compliers versus non-compliers

Author: Pauline Genin, David Thivel, B. Pereira, Martine Duclos, Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Centre de Recherche en Nutrition Humaine, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Biostatistiques, Inferential, CHU Clermont-Ferrand, médecine du sport et explorations fonctionnelles, CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques - Clermont Auvergne (AME2P), Faculté des Sciences du SportFaculté des Sciences du Sport, UFR STAPS-Université Clermont Auvergne (UCA), Université Clermont Auvergne (UCA), Unité de Nutrition Humaine 1019, Institut National de la Recherche Agronomique (INRA), Centre Hospitalier Universitaire de Clermont-Ferrand, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), and Centre Hospitalier Universitaire Gabriel Montpied
Subjects: Adult, Male, medicine.medical_specialty, Psychological intervention, Increased physical activity, Physical activity, Health Promotion, Scientific literature, activité physique, 03 medical and health sciences, 0302 clinical medicine, physical exercise, medicine, Tertiary employees, Humans, 030212 general & internal medicine, Workplace, Exercise, Beneficial effects, business.industry, Public health, Rehabilitation, public health, Public Health, Environmental and Occupational Health, Middle Aged, Public relations, 030210 environmental & occupational health, aménagement du temps de travail, 3. Good health, Treatment Adherence and Compliance, Work (electrical), santé publique, occupational health, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Psychology, business, sedentariness, Program Evaluation
Abstract: While worldwide public health policies have emphasized the necessity to create a culture that favors regular physical activity, stakeholders and health institutions keep looking for new strategies and opportune settings. Workplaces have been identified since employees spent a considerable part of their time at work and several worksite interventions have been developed lately. While the actual scientific literature clearly points out the beneficial effects of physical activity programs implemented within companies on employees overall health, available evidences however seem to question their adherence to such interventions. Based on previously published results and new observations, this paper discusses the adherence rate during workplace physical activity programs and suggests new strategies to favor increased physical activity among employees, considering their dropouters or finishers' profiles.
Published: 2018

42. Physical Activity, Inactivity, and Sedentary Behaviors: Definitions and Implications in Occupational Health

Author: David Thivel, Angelo Tremblay, Pauline M. Genin, Shirin Panahi, Daniel Rivière, Martine Duclos, Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques - Clermont Auvergne (AME2P), Faculté des Sciences du SportFaculté des Sciences du Sport, UFR STAPS-Université Clermont Auvergne (UCA), Centre de Recherche en Nutrition Humaine, Faculté des sciences de l'éducation (FUSP), Université Laval, Département de kinésiologie, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Faculté de Médecine, Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, Médecine du Sport et Explorations fonctionnelles, Centre Hospitalier Universitaire Gabriel Montpied, Thivel, D., Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Faculdade de Educacao Sao Paulo (FEUSP), Université Laval [Québec] (ULaval), Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, and Université de Toulouse (UT)
Subjects: Gerontology, medicine.medical_specialty, Mini Review, Physical activity, physical activity, Health outcomes, Occupational safety and health, 03 medical and health sciences, 0302 clinical medicine, medicine, 030212 general & internal medicine, Confusion, Public health, lcsh:Public aspects of medicine, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, 030229 sport sciences, 3. Good health, Santé publique et épidémiologie, sedentary behaviors, inactivity, tertiary employees, 8. Economic growth, occupational health, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Public Health, medicine.symptom, Psychology
Abstract: Based on the increasing evidence linking excessive sedentary behaviors and adverse health outcomes, public health strategies have been developed and constantly improved to reduce sedentary behaviors and increase physical activity levels at all ages. Although the body of literature in this field has grown, confusion still exists regarding the correct definition for sedentary behaviors. Thus, there is a need to provide a clear definition in order to distinguish sedentary behaviors from physical activity and inactivity. This paper will briefly review the most recent and accepted definitions of these concepts and illustrate their relationships. Nowadays, since most working adults spend a high proportion of their waking hours in increasingly sedentary tasks, there will be a particular focus on the field of occupational health. Finally, simple modifications in the workplace will be suggested in order to decrease sedentary behaviors.
Published: 2018

43. Energy depletion by 24-h fast leads to compensatory appetite responses compared with matched energy depletion by exercise in healthy young males

Author: Graham Finlayson, Yves Boirie, Maud Miguet, David Thivel, Éric Doucet, Bruno Pereira, Martine Duclos, Lore Metz, John E. Blundell, Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Centre de Recherche en Nutrition Humaine, Faculty of Medecine and Health, University of Leeds, Biostatistique, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Clermont-Ferrand, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Médecine du sport et explorations fonctionnelles, CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Nutrition Humaine, CHU Fattouma Bourguiba [Monastir] (HFB), School of Human Kinetics, University of Ottawa [Ottawa], Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques - Clermont Auvergne (AME2P), Faculté des Sciences du SportFaculté des Sciences du Sport, UFR STAPS-Université Clermont Auvergne (UCA), Centre Hospitalier Universitaire de Clermont-Ferrand, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Centre Hospitalier Universitaire Gabriel Montpied, Centre Hospitalier Universitaire, and University of Ottawa [Ottawa] (uOttawa)
Subjects: Male, 0301 basic medicine, Hunger, media_common.quotation_subject, Energy balance, Medicine (miscellaneous), Appetite, Satiation, Food Preferences, Young Adult, 03 medical and health sciences, Oxygen Consumption, Animal science, Reward, Surveys and Questionnaires, Food choice, Intermittent fasting, Humans, Medicine, Exercise, Young male, Aerobic capacity, media_common, 2. Zero hunger, 030109 nutrition & dietetics, Nutrition and Dietetics, Energy depletion, business.industry, Food reward, Fasting, Feeding Behavior, Energy deficit, Food restriction, Body Composition, Energy intake, Energy Metabolism, business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract: Although there is a growing interest for the effects of intermittent fasting on energy balance, this study aimed to compare appetite, energy intake and food reward responses with an energy depletion induced either by 24-h food restriction or an equivalent deficit with exercise in healthy males. In all, twelve healthy lean males (21·5 (sd 0·5) years old; BMI: 22·5 (sd 1·7) kg/m2) participated in this study. Body composition, aerobic capacity, food preferences and energy intake were assessed. They randomly completed three conditions: (i) no depletion (CON); (ii) full 24-h energy restrictions (Def-EI); and (iii) exercise condition (Def-EX). Ad libitum energy intake and food reward were assessed at the end of each session. Appetite feelings were assessed regularly. Ad libitum energy intake was higher on Def-EI (7330 (sd 2975) kJ (1752 (sd 711) kcal) compared with that on CON (5301 (sd 1205) kJ (1267 (sd 288) kcal)) (Psd 1741) kJ (1491 (sd 416) kcal) (P=0·38) and between Def-EX and Def-EI (P=0·22). There was no difference in the percent energy ingested from macronutrients. Hunger was lower on CON and Def-EX compared with Def-EI (PPP=0·04), showing a greater preference for high-fat v. low-fat food during Def-EI and Def-EX. Although 24-h fasting leads to increased energy intake at the following test meal (without total daily energy intake difference), increased hunger profile and decreased post-meal food choice fat bias, such nutritional responses are not observed after a similar deficit induced by exercise.
Published: 2018

44. Single Bout Exercise in Children with Juvenile Idiopathic Arthritis: Impact on Inflammatory Markers

Author: Evrard Bertrand, Duché Pascale, Pereira Bruno, Rochette Emmanuelle, Echaubard Stéphane, Merlin Etienne, Hourdé Christophe, Pédiatrie Générale Multidisciplinaire, Centre Hospitalier Universitaire Estaing, Unité CRECHE, Centre d’Investigation Clinique 1405 (CIC), Université d'Auvergne (Clermont Ferrand 1) (UdA), Centre d’Investigation Clinique (CIC), Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques - Clermont Auvergne (AME2P), Faculté des Sciences du SportFaculté des Sciences du Sport, UFR STAPS-Université Clermont Auvergne (UCA), Centre de Recherche en Nutrition Humaine, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Service d’Immunologie, Centre Hospitalier Universitaire Gabriel Montpied, Délégation de la Recherche Clinique et Innovations, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand University Hospital (AOI 2015), Emmanuelle, Rochette, CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Université d'Auvergne - Clermont-Ferrand I (UdA), Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand, Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Impact de l'Activité Physique sur la Santé (IAPS), and Université de Toulon (UTLN)
Subjects: Male, Arthritis, marqueur, Body Mass Index, activité physique, 0302 clinical medicine, physical exercise, Immunologie, Cytokine Receptor gp130, Child, maladie inflammatoire, enfant, ComputingMilieux_MISCELLANEOUS, biology, Venous blood, inflammatory disease, juvénile, Area Under Curve, Alimentation et Nutrition, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, medicine.symptom, arthrite, lcsh:RB1-214, medicine.medical_specialty, Evening, Article Subject, Adolescent, Immunology, Inflammation, Context (language use), 03 medical and health sciences, children, Internal medicine, medicine, lcsh:Pathology, Food and Nutrition, Humans, Pain Management, Interleukin 6, Exercise, 030203 arthritis & rheumatology, marker, Leg, business.industry, Interleukin-6, 030229 sport sciences, Cell Biology, medicine.disease, Receptors, Interleukin-6, Arthritis, Juvenile, biology.protein, Calprotectin, business, Body mass index, Leukocyte L1 Antigen Complex, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Objective. In a context of inflammatory disease such as juvenile idiopathic arthritis (JIA), we do not know what impact physical activity may have on a deregulated immune system. The objective is to measure the impact of a single bout of exercise on plasma inflammatory markers such as calprotectin, IL-6, sIL-6R, sgp130, and the hypothalamic-pituitary-adrenal axis in children with juvenile idiopathic arthritis. Methods. Twelve children with JIA performed a nonexercise control day and a consecutive day that included a 20 min exercise bout at 70% of max-HR at 08:30 am. Venous blood samples were taken at 08:30, 08:50, 09:30, 10:30 am, and 12:00 pm to measure plasma concentrations of calprotectin, IL-6, sIL-6R, sgp130, cortisol, and ACTH. Pain was evaluated at 08:30, 08:50 am, and 06:00 pm. Results. There was a transient twofold increase in postexercise self-evaluated pain (p=0.03) that disappeared in the evening. A single bout of exercise resulted in a 1.7-fold increase in plasma calprotectin (p<0.001) but not IL-6 and its soluble receptors. Calprotectin levels returned to baseline within 3 hours after cessation of exercise. Conclusion. Acute exercise in children with JIA induced slightly musculoskeletal leg pain and transient increased plasma calprotectin levels but not IL-6 levels. Trial registration in ClinicalTrials.gov, reference number NCT 02502539, registered on 29 May 2015.
Published: 2018

45. Results from France's 2018 Report Card on Physical Activity for Children and Youth

Author: Aubert, S. (Salome), Aucouturier, J. (Julien), Vanhelst, J. (Jeremy), Fillon, A. (Alicia), Genin, P. (Pauline), Ganière, C. (Caroline), Praznoczy, C. (Corinne), Larras, B. (Benjamin), Schipman, J. (Julien), Duclos, M. (Martine), Thivel, D. (David), Children's Hospital of Eastern Ontario Research Institute, Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 (URePSSS), Université d'Artois (UA)-Université de Lille-Université du Littoral Côte d'Opale (ULCO), Centre d’études des transformations des activités physiques et sportives (CETAPS), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut de Recherche Interdisciplinaire Homme et Société (IRIHS), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Centre de Recherche en Nutrition Humaine, UGECAM, Institut de recherche biomédicale et d’épidémiologie du sport (IRMES - EA 7329), Université Paris Descartes - Paris 5 (UPD5)-Institut national du sport, de l'expertise et de la performance (INSEP), Observatoire national de l’activité physique et de la sédentarité (ONAPS), Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Médecine du Sport et des Explorations Fonctionnelles, CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, EA 7369, Unité de Recherche Pluridisciplinaire Sport, Santé, Société, Université de Lille, Laboratoire des Adaptations Métaboliques à l’Exercice en conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne (UCA), ONAPS, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Centre Hospitalier Universitaire Gabriel Montpied, Institut national du sport, de l'expertise et de la performance (INSEP)-Université Paris Descartes - Paris 5 (UPD5), Université d'Artois (UA)-Université du Littoral Côte d'Opale (ULCO)-Université de Lille, Ottawa Hospital Research Institute [Ottawa] [OHRI], Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 [URePSSS], Lille Inflammation Research International Center - U 995 [LIRIC], Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques [AME2P], Observatoire national de l’activité physique et de la sédentarité [ONAPS], Centre d’études des transformations des activités physiques et sportives [CETAPS], and Institut national du sport, de l'expertise et de la performance [INSEP]
Subjects: 03 medical and health sciences, 0302 clinical medicine, Physical activity, Orthopedics and Sports Medicine, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, 030229 sport sciences, 030212 general & internal medicine, Psychology, Report card, Developmental psychology
Abstract: Results from France's 2018 Report Card on Physical Activity for Children and Youth
Published: 2018

46. Impact of 10 Days of Intensive Exercise Period (mHealth Grand Tour) on Heart Rate Variability and Links with Glycaemic Excursions in Athletes with Type 1 Diabetes

Author: Lespagnol, E., Bocock, O., Heyman, J., Pereira, B., Gamelin, F. X., Duclos, Martine, Heyman, E., EA 7369, Faculté des Siences du Sport et de l'Education Physique, Université de Lille, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Université Clermont Auvergne (UCA), Centre de Recherche en Nutrition Humaine, Médecine du Sport et des Explorations Fonctionnelles, Centre Hospitalier Universitaire Gabriel Montpied, UMR Transferts Eau & Matiere Milieux Heterogenes, Université de Rennes, Centre National de la Recherche Scientifique (CNRS), Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 (URePSSS), Université d'Artois (UA)-Université du Littoral Côte d'Opale (ULCO)-Université de Lille, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Université de /Rennes, CHU Clermont-Ferrand, and Université d'Artois (UA)-Université de Lille-Université du Littoral Côte d'Opale (ULCO)
Subjects: genetic structures, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], human activities
Abstract: Meeting Abstract P22; Impact of 10 Days of Intensive Exercise Period (mHealth Grand Tour) on Heart Rate Variability and Links with Glycaemic Excursions in Athletes with Type 1 Diabetes
Published: 2018

47. Peanut gastrointestinal delivery oral immunotherapy in adolescents: Results of the build-up phase of a randomized, double-blind, placebo-controlled trial (PITA study)

Author: Etienne Merlin, Emmanuelle Rochette, Bruno Pereira, Paul-Olivier Rouzaire, J.-L. Fauquert, L. Bernard, Elodie Michaud, Nelly Gourdon-Dubois, Bertrand Evrard, Pôle pédiatrique, Unité d’allergologie de l’enfant, Centre Hospitalier Universitaire Estaing, CIC Clermont Ferrand, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre de Pharmacologie Clinique-CHU Gabriel-Montpied, CHU Clermont-Ferrand, CIC - Clermont Ferrand, Institut National de la Santé et de la Recherche Médicale (INSERM), Pole pédiatrique, Unité d’allergologie de l’enfant, Unité de Biostatistiques, Direction de la Recherche Clinique et Innovation (DRCI), Centre Hospitalier Universitaire de Clermont-Ferrand, Département de Pharmacie, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Institut de Chimie de Clermont-Ferrand - Clermont Auvergne (ICCF), Sigma CLERMONT (Sigma CLERMONT)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Service d’Immunologie, Centre Hospitalier Universitaire Gabriel Montpied, UFR Pharmacie, ERTICa, Université d'Auvergne (Clermont Ferrand 1) (UdA), Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Agence Nationale de la Recherche RBHP2013 Fauquert, CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand-Centre de Pharmacologie Clinique, Centre d'Investigation Clinique [CHU Clermont-Ferrand] (CIC 1405), Institut National de la Santé et de la Recherche Médicale (INSERM)-Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI), Institut de Chimie de Clermont-Ferrand (ICCF), SIGMA Clermont (SIGMA Clermont)-Institut de Chimie du CNRS (INC)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), CHU Gabriel Montpied [Clermont-Ferrand], Université d'Auvergne - Clermont-Ferrand I (UdA), Unité de Nutrition Humaine (UNH), and Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])
Subjects: Male, 0301 basic medicine, Arachis, capsules, Peanut allergy, Placebo-controlled study, Administration, Oral, Gastroenterology, 0302 clinical medicine, Prevalence, Immunology and Allergy, Medicine, Ingestion, Child, allergie alimentaire, ComputingMilieux_MISCELLANEOUS, Oral food challenge, Age Factors, peanut allergy, oral immunotherapy, Dysphagia, 3. Good health, Treatment Outcome, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, medicine.symptom, gastrointestinal delivery, medicine.medical_specialty, Randomization, Immunology, Placebo, 03 medical and health sciences, Internal medicine, anaphylaxis, Humans, Peanut Hypersensitivity, Adverse effect, business.industry, Allergens, Antigens, Plant, Immunoglobulin E, medicine.disease, food sensitivity, Gastrointestinal Tract, 030104 developmental biology, 030228 respiratory system, Desensitization, Immunologic, Immunoglobulin G, adolescent, peanut, business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Biomarkers, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, cacahuete
Abstract: Background Oral immunotherapy to peanut is effective in desensitizing patients but has significant side effects including anaphylaxis and gastrointestinal symptoms. In most protocols, peanut is administered in a vehicle food. Objective In an exclusively adolescent population, we tested a new approach using sealed capsules of peanut (gastrointestinal delivery oral immunotherapy or GIDOIT) to bypass the upper gastrointestinal tract. The primary aim was to assess the efficacy of the oral build‐up phase of GIDOIT and the secondary aim to analyse its safety. Methods Adolescents with a history of a clinical allergic reaction after peanut ingestion were included in a 2‐armed, parallel‐design, individually randomized, double‐blind, placebo‐controlled, multicentre trial after a positive double‐blind placebo‐controlled oral food challenge (DBPCFC1). A central randomization centre used computer‐generated tables to allocate treatments. Peanut (or placebo) capsules were ingested daily over a period of 24 weeks with increments every 2 weeks from 2 to 400 mg of peanut protein (pp). Primary outcome was tolerance of 400 mg of pp at DBPCFC2. Results Thirty patients were included between September 2013 and May 2014. At DBPCFC2, unresponsiveness to 400 mg of pp was achieved in 17/21 peanut group patients (2 withdrawn patients) and 1/9 in the placebo group (Intention‐to‐treat analysis, P < .001, absolute difference = 0.7, 95%IC 0.43 0.96). Oropharyngeal symptoms were equally frequent in both groups. No dysphagia or other signs of eosinophilic oesophagitis occurred. Digestive adverse events (AE) were more frequent in the treated group (P = .02), but mild and without compliance issues. Only one severe advent event led to withdrawal in a patient who ingested twice the investigated treatment. Peanut‐specific humoral immune responses were modulated. Conclusion The GIDOIT protocol demonstrated clinical and immunological efficacy and had an acceptable level of safety with weak oropharyngeal symptoms, no dysphagia, mild digestive events and few severe systemic AE.
Published: 2018

48. Health and Fitness Benefits But Low Adherence Rate

Author: Genin, Pauline M., Dessenne, Pascal, Finaud, Julien, Pereira, Bruno, Thivel, David, Duclos, Martine, Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques - Clermont Auvergne (AME2P), Faculté des Sciences du SportFaculté des Sciences du Sport, UFR STAPS-Université Clermont Auvergne (UCA), Université Clermont Auvergne (UCA), Centre de Recherche en Nutrition Humaine, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Faculté de Médecine, Caisse Primaire de l'Assurance Maladie (CPAM), Association Sportive Montferrandaise, Biostatistiques, Inferential, Centre Hospitalier Universitaire de Clermont-Ferrand, Médecine du sport et explorations fonctionnelles, Centre Hospitalier Universitaire Gabriel Montpied, Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Caisse primaire d'assurance maladie (CPAM), CHU Clermont-Ferrand, CHU Gabriel Montpied [Clermont-Ferrand], and CHU Clermont-Ferrand-CHU Clermont-Ferrand
Subjects: worksite, tertiary employees, occupational health, physical fitness, physical activity, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Objective:The aim of this study was to assess the effects of a 10-month structured physical activity intervention implemented within the workplace on overall health indicators among tertiary (office workers) employees.Methods: In this quasi-experimental study, 224 employees followed a 10-month worksite physical activity program. Overall health was assessed at baseline, after 5 months, and by the end of the intervention.Results: Fat mass percentage decreased significantly. There was a time effect favoring push-ups, abdominal strength, flexibility, heart rate postexercise, heart rate +30 seconds, and heart rate +60 seconds postexercise. Anxiety, depression, and eating habits also improved. In total, 45% of participants completed the whole intervention. Conclusion: Although a structured on-site physical activity program supports improved health indicators, adherence remains a concern and requires specialists to develop new strategies.
Published: 2018

49. Allergies et médicaments: mécanismes de présentation de l'antigène au système immunitaire adaptatif

Author: B. Bonnet, Bertrand Evrard, service immunologie, Centre Hospitalier Universitaire de Clermont-Ferrand, Unité de nutrition Humaine, Institut National de la Recherche Agronomique (INRA), Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Centre Hospitalier Universitaire Gabriel Montpied, CHU Clermont-Ferrand, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), and CHU Gabriel Montpied [Clermont-Ferrand]
Subjects: 0301 basic medicine, Hapten, 030201 allergy, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, antigenic repertoire, delayed cell-mediated hypersensitivity, Immunology and Allergy, IgE, dendritic cells, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, 3. Good health
Abstract: Part of special issue:13ème Congrès Francophone d'Allergologie - 17-20 avril 2018 - Paris, Palais des Congrès; Drugs allergies affect more than 7 % of the population and yet the pathophysiological mechanisms are still poorly known. Herein, we summarize the main mechanisms of antigen presentation to the adaptive immune system.; Les allergies aux médicaments concernent environ 7 % de la population et pourtant les mécanismes physiopathologiques sont encore mal connus. Ici sont résumés les principaux mécanismes de présentation de l’antigène au système immunitaire adaptatif.Abstract
Published: 2018

50. Slight chronic elevation of C‐reactive protein is associated with lower aerobic fitness but does not impair meal‐induced stimulation of muscle protein metabolism in healthy old men

Author: Dominique Dardevet, Caroline Buffière, Noël Cano, Carole Migné, Isabelle Savary-Auzeloux, Didier Rémond, Martine Duclos, Serge Hercberg, Nathalie Meunier, François Mariotti, Unité de Nutrition Humaine (UNH), Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université-Institut National de la Recherche Agronomique (INRA), Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne), Physiologie de la Nutrition et du Comportement Alimentaire (PNCA), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Nutritional Epidemiology Research Team, Epidemiology and Biostatistics Center, Université Paris 13 (UP13), Médecine du Sport et Explorations fonctionnelles, CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, National French Grant: Agence Nationale de la Recherche 'Compalimage' Project, Clermont Université-Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Recherche Agronomique (INRA), AgroParisTech-Institut National de la Recherche Agronomique (INRA), Centre Hospitalier Universitaire Gabriel Montpied, and Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université
Subjects: Male, Aging, medicine.medical_specialty, Anabolism, 030309 nutrition & dietetics, Physiology, Abdominal Fat, Protein metabolism, Muscle Proteins, 030209 endocrinology & metabolism, Inflammation, Biology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Insulin resistance, Internal medicine, medicine, Humans, Aerobic exercise, Exercise, Aged, 2. Zero hunger, 0303 health sciences, Skeletal muscle, Postprandial Period, medicine.disease, C-Reactive Protein, Endocrinology, medicine.anatomical_structure, chemistry, Physical Fitness, Ageing, Sarcopenia, Muscle, Insulin Resistance, medicine.symptom, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract: Ageing impairs the muscle anabolic effect of food intake, which may explain muscle loss and an increased risk of sarcopenia. Ageing is also associated with low grade inflammation (LGI), which has been negatively correlated with muscle mass and strength. In rodents, the muscle anabolic resistance observed during ageing and sarcopenia has been ascribed to the development of the LGI. We aimed to investigate this relationship in humans. We studied protein metabolism and physical fitness in healthy elderly volunteers with slight chronic C-reactive protein. Two groups of healthy elderly volunteers were selected on the presence (or not) of a chronic, slight, elevation of CRP (Control: 2 mg l(-1) and
Published: 2015

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