51 results on '"Cerebellar Diseases cerebrospinal fluid"'
Search Results
2. [Legionnaires' disease with pronounced cerebellar involvement: case report and literature review].
- Author
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Lu M, Shen N, Zhu H, and Yao WZ
- Subjects
- Adult, Aged, Cerebellar Diseases cerebrospinal fluid, Cerebellar Diseases diagnostic imaging, Female, Humans, Male, Middle Aged, Neuroimaging, Pneumonia, Young Adult, Cerebellar Diseases etiology, Cerebellum diagnostic imaging, Cerebrospinal Fluid chemistry, Legionnaires' Disease complications, Peripheral Nervous System Diseases etiology
- Abstract
Objective: To summarize the clinical course, neuroimaging and cerebrospinal fluid (CSF) analyses of cerebellar dysfunction in Legionnaires' disease. Methods: A case of Legionnaires' disease with pronounced cerebellar involvement was reported. The related literatures published up to February 2019 were reviewed with "Legionella, legionellosis, legionnaires' disease, cerebellum, cerebellar" as the keywords in CNKI, Wanfang and PubMed databases. Results: A 69-year-old man complained of anorexia and diarrhea for several days. He was subsequently admitted to the hospital after he had fever, ataxia, dysarthria and involuntary tremor. Chest CT revealed right lower lobe pneumonia. Routine urinalysis showed hematuria and proteinuria. Serum alanine transaminase was 52 U/L, creatinine 137 μmol/L, sodium 128 mmol/L, and creatine kinase 6 893 U/L. Cranial CT was normal. Analysis of CSF showed mildly elevated total protein. Legionella colonies isolated from bronchoalveolar lavage fluid was positive by PCR. After initial treatment with moxifloxacin and azithromycin for 7 days, the fever and neurological symptoms persisted. Corticosteroid therapy was administered for 3 days, the fever resolved, whereas the neurological symptoms improved gradually and slowly by 4 weeks of antibiotic therapy. Finally, successive serological test confirmed Legionella pneumophila serogroups 6 and 7 by indirect immunofluorescence. Twenty-one literatures with 23 cases were reviewed, and plus our case, there were a total of 24 cases for analysis. There were 16 males and 8 females, aged from 22 to 71 years. Ataxia and dysarthria were the cerebellar symptoms most frequently reported, occurring in 22 and 18 cases, respectively. All patients had various central and peripheral neuropathies during their illness. Neuroimaging and analysis of CSF was reported in 21 cases. There were no abnormalities in 18 cases of cranial imaging, 1 case with slight hydrocephalus on cranial CT, and 3 cases with hyperintensity in the splenium of corpus callosum on cranial MRI. Eighteen cases of CSF analyses were normal, whereas 1 case with elevated lymphocytes and 3 cases with elevated proteins. Nine cases were eventually identified as Legionella pneumophila serotype 1 by urinary antigen detection, 1 case as Legionella pneumophila serogroups 6 and 7, while the remaining 14 were unknown serotype. Long-term neurologic follow-up showed that 3 cases recovered completely in the first week, while 19 cases improved slowly in the following 3 weeks, and 13 cases had persistent deficits of gait or speech after 3 months. Conclusions: Legionellosis with cerebellar insufficiency is rare. It may be misdiagnosed in the onset of illness. After treatment, there is a trend of slow recovery and neurological symptoms may persist in long-term follow-up.
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- 2020
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3. Cerebral folate deficiency in adults: A heterogeneous potentially treatable condition.
- Author
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Masingue M, Benoist JF, Roze E, Moussa F, Sedel F, Lubetzki C, and Nadjar Y
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- Adolescent, Adult, Aged, Calcinosis diagnostic imaging, Calcinosis etiology, Calcinosis genetics, Cerebellar Diseases cerebrospinal fluid, Cerebellar Diseases diagnostic imaging, Cerebellar Diseases genetics, Child, Child, Preschool, Female, Folic Acid cerebrospinal fluid, Folic Acid Deficiency cerebrospinal fluid, Folic Acid Deficiency diagnostic imaging, Follow-Up Studies, Humans, Infant, Infant, Newborn, Intellectual Disability, Magnetic Resonance Imaging, Male, Middle Aged, Mitochondrial Diseases diagnostic imaging, Mitochondrial Diseases etiology, Retrospective Studies, Tetrahydrofolates cerebrospinal fluid, White Matter diagnostic imaging, White Matter pathology, Young Adult, Cerebellar Diseases complications, Folic Acid Deficiency complications, Folic Acid Deficiency genetics, Mutation genetics, Proteins genetics
- Abstract
Objective: To describe the phenotype and the response to folinic acid supplementation of cerebral folate deficiency (CFD) in adults, a disorder diagnosed on low 5-methyltetrahydro-folate (5MTHF) in cerebrospinal fluid (CSF), which can correspond to a inherited disorder of folate metabolism (IDFM) or to a metabolic consequence of various neurological diseases., Methods: We conducted a retrospective study on 224 adult patients with neurological symptoms who had a 5MTHF CSF dosage, collecting their neurologic and neuroimaging data., Results: 69 patients had CFD (CSF 5MTHF level < 41 nmol/L), 25 of them had severe CFD (sCFD; ≤25 nmol/L) with adult onset neurological symptoms in 41%. 56% of sCFD patients had an underlying identified neurologic disorder, mainly mitochondrial diseases, hepatic encephalopathy and primary brain calcifications (no identified IDFM), the others were classified as undiagnosed. sCFD patients presented most frequently pyramidal syndrome (75%), movement disorders (56%), cerebellar syndrome (50%) and intellectual disability (46%). MRI findings mostly showed white matter abnormalities (WMA; 32%) and calcifications (12%), and were normal in 23%. The clinico-radiological phenotype of sCFD patients was not clearly different from non CFD patients in terms of manifestations frequency. However, their neurological picture was more complex with a higher number of combined neurological symptoms (4.7±1.6 vs 3.4±1.7, p = .01). In Magnetic Resonance Spectroscopy (MRS), Choline/Creatine (Cho/Cr) ratio was lower in sCFD patients (n = 7) compared to non-CFD patients (n = 73) (p = .005), with good sensitivity (71%) and excellent specificity (92%). Among twenty-one CFD patients treated with folinic acid, nine had a sustained improvement, all with sCFD but one (50% of sCFD patients improved). In two undiagnosed patients with extremely low 5MTHF CSF values, MRI WMA and low Cho/Cr ratios, folinic acid treatment leaded to a dramatic clinical and radiological improvement., Conclusion: CSF 5MTHF dosage should be considered in patients with mitochondrial diseases, primary brain calcifications and unexplained complex neurological disorders especially if associated with WMA, since folinic acid supplementation in patients with sCFD is frequently efficient., (Copyright © 2018. Published by Elsevier B.V.)
- Published
- 2019
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4. Acute cerebellitis in adults: a case report and review of the literature.
- Author
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Van Samkar A, Poulsen MNF, Bienfait HP, and Van Leeuwen RB
- Subjects
- Acute Disease, Adult, Encephalitis pathology, Female, Humans, Magnetic Resonance Imaging, Cerebellar Diseases cerebrospinal fluid, Cerebellar Diseases pathology
- Abstract
Background: Acute cerebellitis is a rare disease with the majority of cases described in children. Little is known about the clinical characteristics and outcome in adults., Case Presentation: A 37-year-old Caucasian woman presented with headache, nausea, and photophobia, and was diagnosed as having a migraine attack. Two days later, she subsequently returned with aggravated headache, dysarthria and horizontal nystagmus. Magnetic resonance imaging (MRI) showed a swollen cerebellum and hydrocephalus and the patient was diagnosed with acute cerebellitis. Cerebrospinal fluid (CSF) examination showed an elevated leukocyte count and protein. Blood serology showed the presence of immunoglobulin M and immunoglobulin G for both Epstein-Barr virus and cytomegalovirus. The patient was treated with dexamethasone and discharged to a rehabilitation center, where she fully recovered. We searched the literature for adult cases of acute cerebellitis. Including our patient, we identified 35 patients with a median age of 36 years. The etiology was unknown in 34% of cases. The most common clinical presentation consisted of headache, nausea/vomiting and ataxia. Six patients presented with only headache and nausea and subsequently returned with cerebellar signs. In 9 cases, the cerebellitis was complicated by hydrocephalus. Half of the patients ended up with neurological sequelae, while follow-up MRI was abnormal in 71%., Conclusion: Acute cerebellitis in adults is a rare disorder which mainly presents with headache, nausea/vomiting and ataxia. To diagnose cerebellitis, imaging of the brain (preferably MRI) is required and CSF examination may be necessary to narrow the differential diagnosis. The treatment depends on the widely diverse etiology, and treatment with steroids is recommended in the case of cerebellar oedema and hydrocephalus. Neurosurgical intervention may be necessary to prevent brain herniation.
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- 2017
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5. Cerebellar disease associated with anti-glutamic acid decarboxylase antibodies: review.
- Author
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Baizabal-Carvallo JF and Alonso-Juarez M
- Subjects
- Humans, Antibodies blood, Antibodies cerebrospinal fluid, Cerebellar Diseases blood, Cerebellar Diseases cerebrospinal fluid, Cerebellar Diseases immunology, Glutamate Decarboxylase immunology
- Abstract
Several neurological syndromes have been recognized associated to GAD antibodies. Among those disorders, cerebellar ataxia (CA) is one of the most common, along with stiff-person syndrome. Patients with GAD associated CA present with a progressive pancerebellar syndrome, with a subacute or chronic evolution, along with other neurological manifestations such as stiffness, oculomotor dysfunction, epilepsy, and cognitive dysfunction. These symptoms may be preceded by the so-called "brainstem attacks", where manifestations consistent with transient dysfunction of the brainstem may be observed. These patients frequently have extra-neurologic autoimmune manifestations such as diabetes mellitus type 1, polyendocrine autoimmune syndrome, pernicious anemia, vitiligo, etc. A proportion of patients may present with an underlying neoplasia, but the course is less aggressive than in those patients with classical paraneoplastic CA with onconeural antibodies. The diagnosis is based on the present of high serum and CSF titers of GAD antibodies, with intrathecal production of such antibodies. Treatment is aimed to decrease the immunological response with intravenous immunoglobulin, steroids, rituximab and oral immunosuppressive drugs. A subacute presentation and rapid initiation of immunotherapy seem to be the predictors of a favorable clinical response.
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- 2017
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6. Selection of the R263K mutation to dolutegravir in cerebrospinal fluid HIV-1 virus in one patient with HIV-associated neurocognitive disorders.
- Author
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Vassallo M, De Monte A, Durant J, Dunais B, and Cottalorda J
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- Cerebellar Diseases cerebrospinal fluid, Cerebellar Diseases diagnosis, Drug Resistance, Viral, Female, HIV Infections cerebrospinal fluid, HIV Infections drug therapy, HIV Integrase, Humans, Middle Aged, Neurocognitive Disorders, Oxazines, Piperazines, Pyridones, Recurrence, Viral Load, Anti-Retroviral Agents therapeutic use, Cerebellar Diseases etiology, HIV Infections complications, HIV Integrase Inhibitors adverse effects, HIV-1 genetics, Heterocyclic Compounds, 3-Ring adverse effects, Mutation
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- 2016
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7. Total folate and 5-methyltetrahydrofolate in the cerebrospinal fluid of children: correlation and reference values.
- Author
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Akiyama T, Tada H, Shiokawa T, Kobayashi K, and Yoshinaga H
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- Adolescent, Cerebellar Diseases cerebrospinal fluid, Cerebellar Diseases diagnosis, Child, Child, Preschool, Chromatography, High Pressure Liquid, Early Diagnosis, Humans, Infant, Reference Values, Tandem Mass Spectrometry, Folic Acid cerebrospinal fluid, Folic Acid Deficiency cerebrospinal fluid, Folic Acid Deficiency diagnosis, Tetrahydrofolates cerebrospinal fluid
- Abstract
Background: Cerebral folate deficiency (CFD) may be underdiagnosed, as it manifests with various non-specific neurological symptoms. The diagnosis of CFD requires a determination of 5-methyltetrahydrofolate (5MTHF) in the cerebrospinal fluid (CSF), which is available in a limited number of specialized laboratories. In clinical biochemistry laboratories, total folate (TF) determination in serum or plasma is routinely performed by automated analyzers. The aim of this study is to determine whether the automated assay of CSF TF is a helpful screening tool for CFD., Methods: We analyzed CSF samples collected from 73 pediatric patients. We measured CSF TF, serum TF, and CSF 5MTHF in 73, 70, and 48 patients, respectively. The assay of 5MTHF was conducted by a newly developed system utilizing liquid chromatography-tandem mass spectrometry (LC-MS/MS). We investigated the correlation between TF and 5MTHF in the CSF., Results: There was a strong positive correlation between CSF TF and 5MTHF (ρ=0.930, p<0.0001, n=48). Age was negatively correlated with CSF TF (ρ=-0.557, p<0.0001, n=51), serum TF (ρ=-0.457, p=0.0008, n=51), and CSF 5MTHF (ρ=-0.387, p=0.0263, n=33), but not with the CSF/serum TF ratio., Conclusions: The automated assay of CSF TF is helpful to estimate CSF 5MTHF. The CSF TF assay may have a significant impact on the early diagnosis of CFD, because clinicians have better access to it than the 5MTHF assay.
- Published
- 2015
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8. 14-3-3 proteins, particularly of the epsilon isoform, are detectable in cerebrospinal fluids of cerebellar diseases in children.
- Author
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Fujii K, Uchikawa H, Tanabe Y, Omata T, Nonaka I, and Kohno Y
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- Cerebellar Diseases etiology, Cerebellar Diseases pathology, Cerebellar Diseases virology, Cerebellum metabolism, Cerebellum pathology, Child, Child, Preschool, Female, Humans, Infant, Influenza, Human cerebrospinal fluid, Influenza, Human complications, Magnetic Resonance Imaging, Male, 14-3-3 Proteins cerebrospinal fluid, Cerebellar Diseases cerebrospinal fluid, Protein Isoforms cerebrospinal fluid
- Abstract
Background: Detection of 14-3-3 proteins in cerebrospinal fluid (CSF) is a powerful tool for elucidating the mechanisms of neurological disorders. There have been useful studies on 14-3-3 CSF protein detection in Creutzfeldt-Jakob disease and other neurological disorders, but none on cerebellar diseases., Objective: To elucidate whether 14-3-3 CSF proteins are a sensitive biomarker of cerebellar disruption in children., Materials and Methods: We examined 14-3-3 CSF proteins by immunoblotting in seven patients with cerebellar disorders: two with acute cerebellitis, two with acute cerebellar ataxia, and three with cerebellar atrophy. We also investigated 14-3-3 CSF proteins in four cases of febrile seizure and three of influenza-related encephalopathy. Isoforms of 14-3-3 proteins were also identified using isoform-specific antibodies., Results: 14-3-3 proteins were detected in CSF of six patients with cerebellar disorders, the exception being one with acute cerebellar ataxia caused by viral infection. Interestingly, only the 14-3-3 ε isoform was detected in two tested patients with cerebellar involvement. Moreover, longitudinal analysis of 14-3-3 CSF proteins in one patient with infantile neuroaxonal dystrophy showed that the 14-3-3 band density proportionally decreased when the cerebellar atrophy gradually progressed. Another CSF derived from a case of febrile seizure showed no 14-3-3 proteins, whereas all those derived from influenza-related encephalopathy demonstrated 14-3-3 CSF proteins with six isoforms., Conclusions: This is the first report on 14-3-3 CSF proteins as a significant biomarker of cerebellar disruption, as well as other brain diseases. Since 14-3-3 ε is localized in the molecular layer of cerebellum, the unique detection of 14-3-3 ε may indicate cerebellar involvement in the brain., (Copyright © 2012 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.)
- Published
- 2013
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9. Balanced steady-state free-precession MR imaging for measuring pulsatile motion of cerebellar tonsils during the cardiac cycle: a reliability study.
- Author
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Sharma A, Parsons MS, and Pilgram TK
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- Adolescent, Adult, Cerebellar Diseases cerebrospinal fluid, Child, Child, Preschool, Female, Foramen Magnum physiopathology, Humans, Infant, Logistic Models, Male, Reproducibility of Results, Retrospective Studies, Cardiac-Gated Imaging Techniques methods, Cerebellar Diseases physiopathology, Cerebellum physiopathology, Magnetic Resonance Imaging methods
- Abstract
Introduction: Assessment of the motion of the cerebellar tonsils is of interest in diseases affecting the CSF flow at the foramen magnum. Cardiac-gated balanced steady-state free-precession technique, which has recently been shown to demonstrate the pulsatile motion of neural structures, appears well suited to allow direct measurement of craniocaudal translation of cerebellar tonsils during the cardiac cycle. Our aim was to assess the intra-observer and inter-observer variability in the assessment of tonsillar motion utilizing this technique., Methods: We retrospectively identified 44 patients who had undergone MR imaging with cine TrueFISP sequence, as a part of CSF flow study. Two neuroradiologists independently assessed the images. The tonsillar pulsatility was subjectively characterized into none, minimal, and marked categories after review of the images on a cine loop. For patients with identifiable tonsillar motion, the maximal extent of translation of the inferior edge of the cerebellar tonsil was directly measured. Both readers repeated the measurements after a minimum interval of 2 weeks. Intra- and inter-observer variability was characterized by calculating the kappa statistics., Results: The intra-observer agreement for subjective assessment of tonsillar pulsatility was near perfect while the inter-observer agreement was substantial. A good intra- and inter-observer correlation was also seen for the objective measurements of the tonsillar motion. A good correlation was found between the subjective categorization of the tonsillar pulsatility and the objective measurements., Conclusion: Steady-state balanced free-precession MR imaging technique allows for a reproducible subjective and objective assessment of tonsillar pulsatility.
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- 2012
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10. Bri2-23 is a potential cerebrospinal fluid biomarker in multiple sclerosis.
- Author
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Harris VK, Diamanduros A, Good P, Zakin E, Chalivendra V, and Sadiq SA
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- Adaptor Proteins, Signal Transducing, Adolescent, Adult, Aged, Aged, 80 and over, Biomarkers cerebrospinal fluid, Cerebellar Diseases etiology, Cognition Disorders etiology, Female, Humans, Male, Membrane Glycoproteins, Middle Aged, Multiple Sclerosis diagnosis, Young Adult, Cerebellar Diseases cerebrospinal fluid, Cerebellar Diseases metabolism, Cognition Disorders cerebrospinal fluid, Cognition Disorders metabolism, Membrane Proteins cerebrospinal fluid, Multiple Sclerosis cerebrospinal fluid, Multiple Sclerosis metabolism
- Abstract
To identify potential multiple sclerosis (MS)-specific biomarkers, we used a proteomic approach to screen cerebrospinal fluid (CSF) from 40 MS patients and 13 controls. We identified seven proteins (Beta-2-microglobulin, Bri2-23, Fetuin-A, Kallikrein-6, Plasminogen, Ribonuclease-1, and Transferrin) that had significantly altered levels in MS compared to controls. Clinical subgroup analysis revealed that decreased CSF levels of Bri2-23, a peptide cleaved from Bri2, were significantly associated with patients having cerebellar dysfunction and cognition impairment. Furthermore, expression levels of Bri2 were specifically decreased in the cerebellum compared to other areas of same brain in MS but not in controls, suggesting that decreased cerebellar Bri2 expression may play a role in cerebellar dysfunction. The association with cognition impairment is also of interest because Bri2 is linked to the amyloid processing pathway in the brain. CSF levels of Bri2-23 may serve as a biomarker of these functions in MS and merits further investigation., ((c) 2010 Elsevier Inc. All rights reserved.)
- Published
- 2010
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11. Central system nervous tuberculosis in infants.
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Tinsa F, Essaddam L, Fitouri Z, Boussetta K, Ben Becher S, and Bousnina S
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- Brain diagnostic imaging, Brain pathology, Cerebellar Diseases cerebrospinal fluid, Cerebellar Diseases diagnosis, Cerebellar Diseases pathology, Child, Preschool, Diabetes Insipidus etiology, Female, Follow-Up Studies, Humans, Hydrocephalus cerebrospinal fluid, Hydrocephalus diagnosis, Hydrocephalus pathology, Infant, Magnetic Resonance Imaging, Male, Pituitary Diseases cerebrospinal fluid, Pituitary Diseases diagnosis, Pituitary Diseases pathology, Pons diagnostic imaging, Pons pathology, Time Factors, Tomography, X-Ray Computed, Tuberculoma, Intracranial cerebrospinal fluid, Tuberculoma, Intracranial diagnosis, Tuberculoma, Intracranial pathology, Tuberculosis, Central Nervous System cerebrospinal fluid, Tuberculosis, Central Nervous System pathology, Tuberculosis, Central Nervous System diagnosis
- Abstract
The lack of specific symptoms and signs in patients with tuberculous meningitis makes early diagnosis difficult. In this report, we reviewed the clinical features and laboratory findings of 6 infants with central system nervous tuberculosis during a 10-year period. One of the patients had multifocal tuberculosis. The mean time to the diagnosis was 32 +/- 13.4 days. A contact source was identified in only 2 patients. All 6 patients had abnormal cerebrospinal fluid findings, less than 500 cells/microL with lymphocytic predominance. Computerized tomography (CT) and/or magnetic resonance imaging (MRI) revealed hydrocephalus with basal enhancement in 2 patients. One patient developed pontocerebellar and pituitary tuberculomas, which were responsible for compression and diabetes insipidus, 1 year after antituberculous treatment. These localizations are very rare. On the follow-up, 3 patients had hypoacousia and only 1 had severe sequelae, despite a diagnostic delay.
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- 2010
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12. Elevated B-cell activating factor BAFF, but not APRIL, correlates with CSF cerebellar autoantibodies in pediatric opsoclonus-myoclonus syndrome.
- Author
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Fühlhuber V, Bick S, Kirsten A, Hahn A, Gerriets T, Tschernatsch M, Kaps M, Preissner KT, Blaes F, and Altenkämper S
- Subjects
- Antibody Formation immunology, Autoantibodies analysis, B-Cell Activating Factor blood, B-Cell Activating Factor cerebrospinal fluid, Biomarkers analysis, Biomarkers blood, Biomarkers cerebrospinal fluid, Blood-Brain Barrier immunology, Cerebellar Diseases cerebrospinal fluid, Cerebellar Diseases physiopathology, Cerebellum immunology, Cerebellum pathology, Cerebellum physiopathology, Child, Preschool, Female, Humans, Male, Opsoclonus-Myoclonus Syndrome blood, Opsoclonus-Myoclonus Syndrome cerebrospinal fluid, Predictive Value of Tests, Subarachnoid Space immunology, Subarachnoid Space metabolism, Tumor Necrosis Factor Ligand Superfamily Member 13 analysis, Tumor Necrosis Factor Ligand Superfamily Member 13 blood, Up-Regulation immunology, Autoantibodies cerebrospinal fluid, B-Cell Activating Factor analysis, Cerebellar Diseases immunology, Lymphocyte Activation immunology, Opsoclonus-Myoclonus Syndrome immunology
- Abstract
Childhood opsoclonus-myoclonus syndrome (OMS) occurs idiopathic or, in association with a neuroblastoma, as a paraneoplastic syndrome. Since autoantibodies were identified in some patients, an autoimmune pathogenesis has been suspected. While the newly discovered B-cell activating factors BAFF and APRIL are involved in systemic autoimmune diseases, their association with neuroimmunological diseases is hardly understood. We here investigated the BAFF and APRIL levels in serum and cerebrospinal fluid (CSF) of OMS patients and their correlation with surface-binding autoantibodies. BAFF and APRIL were both determined by ELISA, and autoantibodies to cerebellar granular neurons (CGN) have been investigated by flow cytometry in 17 OMS patients, 16 neuroblastoma (NB) patients, 13 controls and 11 children with inflammatory neurological diseases (IND). BAFF, but no APRIL, was elevated in the CSF of OMS children and IND children. However, in contrast to IND patients, OMS patients did not have a blood-brain-barrier disturbance, indicating that BAFF was produced intrathecally in OMS patients, but not in IND patients. CSF BAFF levels showed a correlation with CSF CGN autoantibodies (r(2)=0.58, p<0.05). These data indicate that an activated B-cell system in the cerebrospinal fluid is involved in the pathogenesis of OMS, and BAFF may be a candidate parameter for the activation of B-cell immune system.
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- 2009
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13. Remote cerebellar hemorrhage: a review.
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Brockmann MA and Groden C
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- Humans, Magnetic Resonance Imaging methods, Neurosurgical Procedures methods, Tomography, X-Ray Computed methods, Cerebellar Diseases cerebrospinal fluid, Cerebellar Diseases pathology, Cerebellar Diseases surgery, Cerebral Hemorrhage cerebrospinal fluid, Cerebral Hemorrhage pathology, Cerebral Hemorrhage surgery
- Abstract
Remote cerebellar hemorrhage remains a complication rarely occurring after supratentorial surgery (<5%) and presumably even less frequent after spinal surgery. Although the pathomechanisms leading to RCH with its typical bleeding pattern are still not definitely understood, intra- or even more likely postoperative loss of larger volumes of CSF seem to be related to this complication. Prognosis significantly depends on severity of hemorrhage and patient age. Outcome in more than 50% of all cases is good with only mild remaining neurological symptoms or complete recovery, while death occurs in approximately 10-15%. Close monitoring of patients undergoing surgery that involves the risk of draining large volumes of CSF is mandatory and patients with postoperative drainage of larger amounts of fluid acquire increased attentiveness. Early detection and correct interpretation of the typical bleeding pattern might help to avoid further aggravation of symptoms. This review will address incidence, typical appearance and pathophysiological considerations, as well as risk factors, treatment options, and outcome related with RCH.
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- 2006
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14. Detection of herpesvirus-6A in a case of subacute cerebellitis and myoclonic dystonia.
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Borghi E, Pagani E, Mancuso R, Delbue S, Valli M, Mazziotti R, Giordano L, Micheli R, and Ferrante P
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- Cerebellar Diseases blood, Cerebellar Diseases cerebrospinal fluid, Chickenpox complications, Chickenpox virology, Child, Preschool, Dystonia blood, Dystonia cerebrospinal fluid, Dystonia complications, Exanthema Subitum complications, Exanthema Subitum virology, Female, Humans, Myoclonus blood, Myoclonus cerebrospinal fluid, Myoclonus complications, Roseolovirus Infections complications, Roseolovirus Infections virology, Cerebellar Diseases virology, Dystonia virology, Herpesvirus 6, Human isolation & purification, Myoclonus virology
- Abstract
This is a case study of a child who developed roseola infantum first, then varicella, and was later affected by acute cerebellar syndrome, severe truncal ataxia, and myoclonic dystonia. Human herpesvirus 6 (HHV-6) A and B were detected in the cerebrospinal fluid (CSF) and peripheral blood, respectively, upon ataxia onset. The intricacy of this case suggests multifaceted conclusions ranging from the need for a multidirectional approach to neurological diseases, to confirmation of a more pronounced neurotropism of HHV-6A and a possible role of viruses in myoclonic dystonia syndrome, although this last hypothesis should be confirmed by larger studies., (2005 Wiley-Liss, Inc.)
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- 2005
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15. Paraneoplastic antibodies detected by isoelectric focusing of cerebrospinal fluid and serum.
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Storstein A, Monstad SE, Honnorat J, and Vedeler CA
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- Blood Proteins immunology, Cerebellar Diseases blood, Cerebellar Diseases cerebrospinal fluid, Cerebellar Diseases immunology, Cerebrospinal Fluid immunology, DNA-Binding Proteins analysis, DNA-Binding Proteins blood, DNA-Binding Proteins cerebrospinal fluid, ELAV Proteins, Encephalomyelitis blood, Encephalomyelitis cerebrospinal fluid, Encephalomyelitis immunology, Humans, Immunoenzyme Techniques, Immunoglobulin G analysis, Immunoglobulin G blood, Immunoglobulin G cerebrospinal fluid, Isoelectric Focusing methods, Neoplasm Proteins analysis, Neoplasm Proteins blood, Neoplasm Proteins cerebrospinal fluid, Nerve Tissue Proteins analysis, Nerve Tissue Proteins blood, Nerve Tissue Proteins cerebrospinal fluid, Oligoclonal Bands blood, Oligoclonal Bands cerebrospinal fluid, Paraneoplastic Syndromes immunology, Predictive Value of Tests, RNA-Binding Proteins analysis, RNA-Binding Proteins blood, RNA-Binding Proteins cerebrospinal fluid, Sulfur Radioisotopes, Autoantibodies blood, Autoantibodies cerebrospinal fluid, Blood Proteins analysis, Cerebrospinal Fluid chemistry, Paraneoplastic Syndromes blood, Paraneoplastic Syndromes cerebrospinal fluid
- Abstract
Patients with paraneoplastic neurological syndromes often produce intrathecal antibodies. We have employed isoelectric focusing and peroxidase-labeled anti-IgG or 35S-labeled Hu or Yo antigens to identify oligoclonal bands (OCB) representing either total IgG or Hu or Yo antibodies in serum and CSF of patients with paraneoplastic encephalomyelitis (PEM) or paraneoplastic cerebellar degeneration (PCD). OCBs representing paraneoplastic antibodies were found in all CSF, but in only three sera. Yo antibodies represented the majority of IgG bands in PCD-CSF, which may reflect a limited immune response, whereas in PEM/SN, there were numerous additonal IgG bands of unknown specificity, indicating a broader immune response in these patients., (Copyright 2004 Elsevier B.V.)
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- 2004
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16. Cerebellitis in an adult with abnormal magnetic resonance imaging findings prior to the onset of ataxia.
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Gruis KL, Moretti P, Gebarski SS, and Mikol DD
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- Adult, Cerebellar Ataxia cerebrospinal fluid, Cerebellar Ataxia diagnostic imaging, Cerebellar Diseases cerebrospinal fluid, Cerebellar Diseases diagnostic imaging, Cerebellum diagnostic imaging, Female, Humans, Leukocyte Count, Leukocytosis pathology, Magnetic Resonance Imaging, Tomography, Emission-Computed, Single-Photon, Cerebellar Ataxia pathology, Cerebellar Diseases pathology
- Abstract
Background: Brain magnetic resonance imaging (MRI) findings during acute cerebellar ataxia in cases of postinfectious cerebellitis are frequently normal. This has resulted in the use of other imaging modalities, such as single-photon emission computed tomography, to aid diagnosis., Objective: To illustrate the chronologic occurrence of cerebellar ataxia, abnormal findings on MRI, and cerebral spinal fluid pleocytosis in an adult case of postinfectious cerebellitis., Methods: Case report., Results: A patient with a 6-week history of occipital headaches and only mild tandem gait difficulty had abnormal MRI findings that were consistent with cerebellar inflammation. As cerebellar ataxia progressed in parallel with cerebral spinal fluid pleocytosis, MRI findings indicative of cerebellar inflammation resolved, while single-photon emission computed tomography showed cerebellar hyperperfusion. Recovery of neurologic function was accompanied by clearing of the pleocytosis and residual MRI-detected cerebellar atrophy., Conclusion: This case demonstrates that transient abnormalities can be detected by MRI before clinical manifestations of cerebellitis appear, while hyperperfusion detected by single-photon emission computed tomography is prolonged.
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- 2003
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17. Acute cerebellitis caused by herpes simplex virus type 1.
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Ciardi M, Giacchetti G, Fedele CG, Tenorio A, Brandi A, Libertone R, Ajassa C, Borgese L, and Delia S
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- Acute Disease, Adolescent, Adult, Cerebellar Diseases cerebrospinal fluid, DNA, Viral cerebrospinal fluid, Female, Herpesvirus 1, Human genetics, Humans, Polymerase Chain Reaction, Cerebellar Diseases virology, Herpesvirus 1, Human isolation & purification
- Abstract
Cerebellar disorders due to herpes simplex virus (HSV) infection are rare and always associated with herpes simplex encephalitis. We report 2 cases of severe primary acute cerebellitis caused by HSV type 1 that were identified by nested polymerase chain reaction performed on cerebrospinal fluid samples.
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- 2003
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18. [Infection due to Mycoplasma pneumoniae: three cases with neurological complications].
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Cunha J, Madalena C, Guimarães P, Sousa A, and Temudo T
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- Adolescent, Brain diagnostic imaging, Brain microbiology, Brain pathology, Cerebellar Diseases cerebrospinal fluid, Cerebellar Diseases diagnosis, Child, Encephalomyelitis, Acute Disseminated cerebrospinal fluid, Encephalomyelitis, Acute Disseminated diagnosis, Female, Humans, Male, Mycoplasma Infections cerebrospinal fluid, Myelitis, Transverse cerebrospinal fluid, Myelitis, Transverse diagnosis, Radiography, Spinal Cord diagnostic imaging, Spinal Cord microbiology, Spinal Cord pathology, Cerebellar Diseases microbiology, Encephalomyelitis, Acute Disseminated microbiology, Mycoplasma Infections complications, Mycoplasma pneumoniae isolation & purification, Myelitis, Transverse microbiology
- Abstract
Introduction: Mycoplasma pneumoniae infection has been associated with severe central nervous system diseases. The pathogenesis of these disorders is unknown and the treatment uncertain., Case Reports: The authors present three cases of central nervous system diseases: acute transverse myelitis, cerebellitis and encephalomyelitis associated with M. pneumoniae infection., Conclusions: M. pneumoniae infection should be considered in all cases of severe acute central nervous system symptomatology.
- Published
- 2002
19. Mumps with cerebellar encephalitis.
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Shukla A, Kumar P, and Kalra OP
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- Adult, Cerebellar Diseases cerebrospinal fluid, Cerebellar Diseases diagnosis, Encephalitis, Viral cerebrospinal fluid, Encephalitis, Viral diagnosis, Humans, Male, Cerebellar Diseases etiology, Encephalitis, Viral etiology, Mumps complications
- Abstract
A 30 years male patient, having typical symptoms of mumps, presented with acute cerebellar ataxia two days after the onset of parotid enlargement. The neurological symptoms showed complete recovery over the subsequent six weeks, suggestive of para-infectious cerebellar demyelination due to mumps.
- Published
- 2001
20. [Cerebellar syndrome after varicella infection without virus identification in cerebrospinal fluid--an important differential ataxia diagnosis].
- Author
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Schaller B, Bernhard P, Graber P, and Steck AJ
- Subjects
- Adult, Cerebellar Ataxia cerebrospinal fluid, Cerebellar Diseases cerebrospinal fluid, Chickenpox cerebrospinal fluid, Diagnosis, Differential, Encephalomyelitis cerebrospinal fluid, Female, Follow-Up Studies, Humans, Neurologic Examination, Cerebellar Ataxia diagnosis, Cerebellar Diseases diagnosis, Cerebrospinal Fluid virology, Chickenpox diagnosis, Encephalomyelitis diagnosis
- Abstract
We report on a 35 year old female with a 26 day history of an intermittent cerebellar syndrome (dysarthria, ataxia of extremities, gait and trunk, nystagmus), mild meningism, cephalgia, recurrent emesis and nausea. Symptoms developed after typically chickenpox exanthema. Examination of the liquor showed mild pleocytosis, elevated protein and increased albumin quotient. Virus was not found by EIA or PCR. There were elevated levels of IgM- and IgG-antibodies to VZV. The EEG showed mild general changes, compatible with an encephalitis. Neuroradiological examinations were unremarkful. The neurological deficits partly regressed in the follow-up of two months. To the best of our knowledge we are the first that describe the paradox of an intermittent cerebellar syndrome after infection with chickenpox without detection of the virus in the liquor. This phenomenon can be related to the unusual combination of cerebellar ataxia and the later occurrence of mild encephalitis.
- Published
- 1999
21. Low insulin-like growth factor (IGF-1) in the cerebrospinal fluid of children with progressive encephalopathy, hypsarrhythmia, and optic atrophy (PEHO) syndrome and cerebellar degeneration.
- Author
-
Riikonen R, Somer M, and Turpeinen U
- Subjects
- Atrophy diagnosis, Atrophy pathology, Biomarkers, Brain Diseases diagnosis, Cerebellar Diseases diagnosis, Cerebellar Diseases pathology, Cerebellum pathology, Child, Child, Preschool, Diagnosis, Differential, Female, Humans, Infant, Male, Optic Atrophy diagnosis, Spasms, Infantile diagnosis, Syndrome, Brain Diseases cerebrospinal fluid, Cerebellar Diseases cerebrospinal fluid, Insulin-Like Growth Factor I cerebrospinal fluid, Optic Atrophy cerebrospinal fluid, Spasms, Infantile cerebrospinal fluid
- Abstract
Purpose: In patients with progressive encephalopathy, hypsarrhythmia, and optic atrophy (PEHO) syndrome, the pathophysiology underlying early progressive cerebellar and brainstem degeneration and severe epilepsy is unknown. Because insulin-like growth factor (IGF)-1 has been shown significantly to promote survival of cerebellar neurons, we wanted to see if the IGF system played a role in the pathogenesis of cerebellar atrophy., Methods: We used a sensitive enzyme immunoassay kit for measuring cerebrospinal fluid (CSF) IGF-1 and insulin-like growth-binding protein (IGFBP)-3 in four groups of patients: PEHO syndrome patients (eight), PEHO-like patients (seven), age-matched controls (31), and patients with other types of cerebellar atrophy (11)., Results: Patients with PEHO syndrome and those with other progressive, degenerative cerebellar diseases had lower levels of CSF IGF-1 than the controls with other neurologic diseases. The CSF IGF-1 also allowed us to differentiate the "true" PEHO patients from the "PEHO-like" patients (those with similar clinical symptoms but without the typical neuroophthalmologic or neuroradiologic findings). The concentrations of IGFBP-3 did not significantly differ in any of the patient or control groups studied., Conclusions: CSF IGF-1 levels might be used as a marker of the degeneration of neurons in specific areas.
- Published
- 1999
- Full Text
- View/download PDF
22. Failure to detect cytotoxic T cell activity against recombinant Yo protein using autologous dendritic cells as the target in a patient with paraneoplastic cerebellar degeneration and anti-Yo antibody.
- Author
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Tanaka M, Tanaka K, Idezuka J, and Tsuji S
- Subjects
- Autoantibodies cerebrospinal fluid, Autoantigens immunology, Cerebellar Diseases cerebrospinal fluid, Cytotoxicity, Immunologic, Humans, Nerve Degeneration cerebrospinal fluid, Paraneoplastic Syndromes cerebrospinal fluid, Recombinant Proteins immunology, Autoantibodies immunology, Cerebellar Diseases immunology, DNA-Binding Proteins immunology, Dendritic Cells immunology, Neoplasm Proteins immunology, Nerve Degeneration immunology, Nerve Tissue Proteins, Paraneoplastic Syndromes immunology, T-Lymphocytes, Cytotoxic immunology
- Abstract
Paraneoplastic neurological syndromes are believed to be autoimmune neuronal degenerations that develop in some patients with systemic cancer. Although a high titer of anti-Yo antibody has been found in the sera and cerebrospinal fluid of patients with paraneoplastic cerebellar degeneration (PCD), the role of anti-Yo antibody in Purkinje cell loss has not been shown. Previously we found that all of nine Japanese patients with PCD who harbored anti-Yo antibody had HLA A24. In this present study we have examined cytotoxic T cell (CTL) activity against recombinant Yo protein in peripheral blood of a patient with PCD and anti-Yo antibody using autologous dendritic cells as the target. We did not detect CTL activity against Yo protein, though, this study does not exclude the possibility of the involvement of CTL in the development of PCD., (Copyright 1998 Academic Press.)
- Published
- 1998
- Full Text
- View/download PDF
23. Probable post-influenza cerebellitis.
- Author
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Hayase Y and Tobita K
- Subjects
- Adult, Cerebellar Diseases cerebrospinal fluid, Cerebellar Diseases pathology, Cerebrospinal Fluid virology, DNA Primers chemistry, DNA, Viral analysis, Electrophoresis, Agar Gel, Encephalitis, Viral cerebrospinal fluid, Encephalitis, Viral pathology, Female, Humans, Influenza B virus genetics, Influenza B virus isolation & purification, Influenza, Human cerebrospinal fluid, Influenza, Human pathology, Magnetic Resonance Imaging, Nucleocapsid Proteins, Polymerase Chain Reaction, Tomography, X-Ray Computed, Viral Core Proteins genetics, Cerebellar Diseases virology, Encephalitis, Viral etiology, Influenza, Human etiology, Nucleoproteins
- Abstract
The nucleoprotein (NP) gene of type B influenza virus was detected by reverse transcription polymerase chain reaction (RT-PCR) from the cerebrospinal fluid (CSF) of a patient presenting with ataxia due to cerebellitis. The CSF was obtained 7 and 9 weeks after flu syndrome occurred, suggesting persistence of viral genes in the central nervous system (CNS). Although an unusually high serum hemagglutination inhibition (HI) titer against influenza virus B was noted, HI titers of the CSF were not elevated.
- Published
- 1997
- Full Text
- View/download PDF
24. Neurosteroids in cerebrospinal fluid in neurologic disorders.
- Author
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Azuma T, Matsubara T, Shima Y, Haeno S, Fujimoto T, Tone K, Shibata N, and Sakoda S
- Subjects
- Adult, Age Factors, Aged, Brain Neoplasms cerebrospinal fluid, Cerebellar Diseases cerebrospinal fluid, Cerebral Infarction cerebrospinal fluid, Dehydroepiandrosterone Sulfate, Female, Humans, Male, Middle Aged, Parkinson Disease cerebrospinal fluid, Polyradiculoneuropathy cerebrospinal fluid, Radioimmunoassay, Reference Values, Sex Factors, Dehydroepiandrosterone analogs & derivatives, Dehydroepiandrosterone cerebrospinal fluid, Nervous System Diseases cerebrospinal fluid
- Abstract
In order to investigate the role of "neurosteroids" in the central nervous system (CNS), cerebrospinal fluid (CSF) levels of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) were determined by radioimmunoassay in 57 patients with various neurologic disorders and 26 patients with non-neurologic disorders. The content of CSF DHEA and DHEAS in patients with Guillain-Barré syndrome (GBS), and the content of CSF DHEAS in patients with carcinomatous meningitis were significantly higher as compared to non-neurological control patients. These changes may be explained by the breakdown of blood-nerve barrier in these disorders. A significant positive correlation was observed between DHEAS and total protein in CSF. In males but not females, a negative correlation was observed between CSF DHEAS and aging. The level of CSF DHEAS, but not DHEA, was significantly higher in males than in females.
- Published
- 1993
- Full Text
- View/download PDF
25. Cerebrospinal fluid 28-kDa calbindin-D as a possible marker for Purkinje cell damage.
- Author
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Kiyosawa K, Mokuno K, Murakami N, Yasuda T, Kume A, Hashizume Y, Takahashi A, and Kato K
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Biomarkers, Calbindins, Cerebellar Diseases enzymology, Cerebellar Diseases pathology, Child, Child, Preschool, Female, Humans, Immunoenzyme Techniques, Infant, Male, Middle Aged, Nervous System Diseases cerebrospinal fluid, Nervous System Diseases pathology, Phosphopyruvate Hydratase cerebrospinal fluid, Cerebellar Diseases cerebrospinal fluid, Purkinje Cells physiology, S100 Calcium Binding Protein G cerebrospinal fluid
- Abstract
To examine the clinical value of 28-kDa calbindin-D (CaBP) in cerebrospinal fluid (CSF) as a marker for the damage to Purkinje cells, we measured CSF CaBP levels using an enzyme immunoassay method in 107 patients with cerebellar and other neurological diseases, and 26 controls. The mean CaBP level was markedly elevated in patients with cerebellar diseases, and the elevation of CaBP level was more frequent in the diseases involving Purkinje cells, such as multiple system atrophy (MSA) and subacute cerebellar degeneration in association with lung cancer. Further, in MSA patients, the CaBP levels decreased with duration of illness. The mean levels of CaBP were also elevated in some of the other diseases. We conclude that the elevations of CaBP levels are not specific for cerebellar diseases, but CSF CaBP may be a useful marker for examining the Purkinje cell involvement in cerebellar diseases.
- Published
- 1993
- Full Text
- View/download PDF
26. A significant reduction of putative transmitter amino acids in cerebrospinal fluid of patients with Parkinson's disease and spinocerebellar degeneration.
- Author
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Tohgi H, Abe T, Hashiguchi K, Takahashi S, Nozaki Y, and Kikuchi T
- Subjects
- Adult, Aged, Atrophy, Cerebellar Cortex pathology, Cerebellar Diseases cerebrospinal fluid, Humans, Middle Aged, Olivopontocerebellar Atrophies cerebrospinal fluid, Amino Acids cerebrospinal fluid, Neurotransmitter Agents cerebrospinal fluid, Parkinson Disease cerebrospinal fluid, Spinocerebellar Degenerations cerebrospinal fluid
- Abstract
We evaluated the concentrations of the putative transmitter amino acids in the cerebrospinal fluid, and found a significant reduction of glutamate, aspartate, gamma-aminobutyric acid (GABA), and glycine concentrations in parkinsonian patients. There was no difference in amino acid concentrations between parkinsonian patients receiving L-DOPA and those not receiving L-DOPA. A similar decrease of glutamate and aspartate concentrations was found in patients with spinocerebellar degeneration. Concentrations of asparagine, glycine and taurine were also significantly decreased in patients with late cortical cerebellar atrophy.
- Published
- 1991
- Full Text
- View/download PDF
27. Intracranial pressure in African children with cerebral malaria.
- Author
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Newton CR, Kirkham FJ, Winstanley PA, Pasvol G, Peshu N, Warrell DA, and Marsh K
- Subjects
- Animals, Brain Diseases cerebrospinal fluid, Brain Diseases mortality, Brain Diseases parasitology, Brain Stem, Cause of Death, Cerebellar Diseases cerebrospinal fluid, Cerebellar Diseases etiology, Cerebellar Diseases mortality, Cerebellar Diseases physiopathology, Child, Preschool, Coma cerebrospinal fluid, Coma mortality, Encephalocele cerebrospinal fluid, Encephalocele etiology, Encephalocele mortality, Encephalocele physiopathology, Evaluation Studies as Topic, Humans, Malaria cerebrospinal fluid, Malaria mortality, Malaria parasitology, Manometry, Pseudotumor Cerebri cerebrospinal fluid, Pseudotumor Cerebri mortality, Pseudotumor Cerebri parasitology, Retrospective Studies, Spinal Puncture adverse effects, Brain Diseases physiopathology, Coma physiopathology, Intracranial Pressure physiology, Malaria physiopathology, Plasmodium falciparum, Pseudotumor Cerebri physiopathology
- Abstract
Opening lumbar cerebrospinal fluid (CSF) pressure was measured with a paediatric spinal fluid manometer in 26 of 61 Kenyan children (mean age 39 months) with cerebral malaria. In all cases pressure was above normal (mean [SD]22.6 [7.4] cm CSF, range 10.5-36). Clinical features of our patients suggest that intracranial hypertension is important in the pathogenesis of cerebral malaria in children, especially as a cause of death. We suggest that raised intracranial pressure is secondary to increased cerebral blood volume. Lowering intracranial pressure may significantly reduce the mortality and morbidity of cerebral malaria. The potential risks and benefits of lumbar puncture should be considered carefully in patients with suspected cerebral malaria.
- Published
- 1991
- Full Text
- View/download PDF
28. General assay for phosphoproteins in cerebrospinal fluid: a candidate marker for paraneoplastic cerebellar degeneration.
- Author
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Gandy SE, Grebb JA, Rosen N, Albert KA, Devinsky O, Blumberg H, Anderson N, Cedarbaum JM, Porter RJ, and Sedvall G
- Subjects
- Adult, Aged, Aged, 80 and over, Autoradiography, Biomarkers, Cerebellar Diseases blood, Electrophoresis, Polyacrylamide Gel, Female, Humans, Male, Middle Aged, Paraneoplastic Syndromes blood, Phosphoproteins blood, Protein Kinase C blood, Protein Kinase C cerebrospinal fluid, Cerebellar Diseases cerebrospinal fluid, Paraneoplastic Syndromes cerebrospinal fluid, Phosphoproteins cerebrospinal fluid
- Abstract
The components of protein phosphorylation systems (protein kinases, protein phosphatases, and their phosphoprotein substrates) are highly enriched in neuronal cells compared with other cell types. We exploited this relative neuronal enrichment of protein phosphorylation system components to develop a general assay technique for putative protein kinase substrates (phosphoproteins) in human cerebrospinal fluid. Using this cerebrospinal fluid phosphoprotein assay, we have detected a putative protein kinase C substrate protein of apparent Mr 60 kd in 6 of 14 patients with paraneoplastic cerebellar degeneration but not in any of 55 patients with a variety of other neurological diseases. Phosphoproteins in cerebrospinal fluid may provide novel and unique markers for the diagnosis or staging of neuronal diseases as well as offer potential insights into the biochemical characterization of affected neuronal populations.
- Published
- 1990
- Full Text
- View/download PDF
29. [Cerebral chemical factors in the formation of stable reorganization in the central nervous system].
- Author
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Vartanian GA, Balabanov IuV, and Varlinskaia EI
- Subjects
- Animals, Brain Diseases metabolism, Cats, Cerebellar Diseases cerebrospinal fluid, Guinea Pigs, Male, Motor Cortex, Rabbits, Rats, Species Specificity, Brain Chemistry, Cerebellar Diseases metabolism
- Abstract
A model of spinal postural asymmetry produced by unilateral motor cortex destruction was developed. The spinal fixation time of postural asymmetry of cortical origin was determined. CSF way of spreading the factors that induce spinal asymmetry was demonstrated. The factor of spinal asymmetry was shown to be species-nonspecific.
- Published
- 1981
30. [Topography and structure of secondary brain damage in edema associated with supratentorial foci of encephalomalacia].
- Author
-
Szpakowa GM
- Subjects
- Adult, Aged, Brain Edema cerebrospinal fluid, Brain Edema complications, Cerebellar Diseases cerebrospinal fluid, Cerebellar Diseases complications, Encephalomalacia cerebrospinal fluid, Encephalomalacia complications, Female, Humans, Hydrocephalus etiology, Male, Middle Aged, Necrosis, Brain pathology, Brain Edema pathology, Cerebellar Diseases pathology, Encephalomalacia pathology, Hydrocephalus pathology
- Abstract
The paper comprises 70 cases of extensive supratentorial infarctions. The topography and structure of secondary lesions occurring in the region of herniation and displacements caused by the coexisting brain edema were analysed. The extent of edema served as criterion in the division of the material into three groups in dependence on the occurrence of herniations and displacements. Most frequent was herniation of hippocampal uncus and most rare that of the cerebellar vermis. In group I showing no herniations selective necrosis was noted of neurons particularly sensitive to ischemia and anoxia, especially in Sommer's sector of the hippocampus. In group II secondary necrosis was visible in the regions of herniae, and in the group III also in the translocated deep brain structures in the hemisphere contralateral to the infarct and in the brain stem where, moreover, secondary hemorrhages were present. Supratentorial secondary hemorrhages were less frequent. They were noted in the thalamus both on the side of the infarct and in the contralateral hemisphere. Supratentorial necroses were more frequent. Their intensity varied from selective necrosis to Jacob's edematous necrosis. Severe displacement of deep structures and of the brain stem was associated with development of secondary internal hydrocephalus, especially in the hemisphere contralateral to the herniation. To the most important pathogenetic factors causing development of secondary morphological lesions belong disturbances of blood supply occurring as the result of pressure differences between the supra- and infratentorial space, resulting from pressure and displacement of arterial vessels, damage of their walls and distrubances of venous flow and also development of secondary internal hydrocephalus. Extensive necroses and hemorrhages increase the area of primary necrosis. Lesions resulting from herniation, displacement and compression of vessels were superposed on the picture of brain edema both present or passed. Secondary necroses damaging bilaterally structures belonging to the limbic system and reticular formation may be an additional factor in the development of edematous encephalopathy and the development of a psychoorganic syndrome after stroke.
- Published
- 1989
31. Amine metabolites in the cerebrospinal fluid of patients with disseminated sclerosis.
- Author
-
Claveria LE, Curzon G, Harrison MJ, and Kantamaneni BD
- Subjects
- Cerebellar Diseases cerebrospinal fluid, Cerebellar Diseases etiology, Homovanillic Acid cerebrospinal fluid, Humans, Multiple Sclerosis complications, Tremor cerebrospinal fluid, Tremor etiology, Hydroxyindoleacetic Acid cerebrospinal fluid, Multiple Sclerosis cerebrospinal fluid, Phenylacetates cerebrospinal fluid
- Abstract
Mean homovanillic acid and 5-hydroxyindoleacetic acid concentrations were significantly low in the lumbar CSF of a group of patients with disseminated sclerosis (DS) who were severely disabled but not in the CSF of a less severely restricted group with DS. CSF concentrations were also low in a group of patients with superior cerebellar peduncular tremor due to DS and in a single patient with a similar tremor associated with a post-traumatic brain-stem lesion. The interpretation of abnormal CSF amine metabolite concentrations is discussed in the light of these findings.
- Published
- 1974
- Full Text
- View/download PDF
32. Diazepam binding inhibitor-like immunoreactivity (DBI-LI) in human CSF. Correlations with neurological disorders.
- Author
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Ferrero P, Benna P, Costa P, Tarenzi L, Baggio G, Bergamasco B, and Bergamini L
- Subjects
- Adolescent, Adult, Age Factors, Aged, Cerebellar Diseases cerebrospinal fluid, Diazepam Binding Inhibitor, Female, Freezing, Humans, Male, Middle Aged, Multiple Sclerosis cerebrospinal fluid, Nervous System Diseases physiopathology, Neuropeptides isolation & purification, Sex Factors, Tissue Preservation, Nervous System Diseases cerebrospinal fluid, Neuropeptides cerebrospinal fluid
- Abstract
Cerebrospinal fluid (CSF) levels of the anxiogenic neuropeptide diazepam binding inhibitor (DBI) were determined by radioimmunoassay in 281 patients who underwent evaluation for neurological problems. Serial dilution curves and reverse-phase high pressure liquid chromatography showed that the immunoreactive material in CSF behaved just as authentic DBI extracted from human brain. Furthermore in the assay there was no evidence of interference from CSF samples deprived of DBI by immunoaffinity. In 82 patients with no evidence of major lesions in the central nervous system, who acted as controls, the CSF DBI content was shown to be age- and sex-related. No correlation was observed with the CSF protein concentration. In patients with different types of dementia, the levels of CSF DBI were significantly increased in a group with normal pressure hydrocephalus. No significant differences were found between Alzheimer's disease, multi-infarct dementia, or dementia with Parkinson's disease and controls. In non-demented patients with Parkinson's disease the levels of DBI were increased in a subgroup with depressive disturbances whereas no differences was observed in the non-depressed cases. The content of DBI was markedly reduced in 5 cases with olivopontocerebellar atrophy and in 4 with spinocerebellar ataxia. In all the other disorders studied the levels of DBI were similar to or slightly lower (multiple sclerosis) than those of the controls. The origin of DBI in cerebrospinal fluid is uncertain; a number of various possibilities are discussed concerning the proposed role of DBI as modulator of brain GABAergic transmission.
- Published
- 1988
- Full Text
- View/download PDF
33. [Neurochemical investigation on spinocerebellar degeneration--metabolites of biogenic amines in the cerebrospinal fluids].
- Author
-
Arai M, Kurosawa T, Hiyamuta E, Okada M, and Kanai A
- Subjects
- Humans, Biogenic Amines cerebrospinal fluid, Cerebellar Diseases cerebrospinal fluid, Spinal Cord Diseases cerebrospinal fluid
- Published
- 1983
34. Herniated cerebellar tonsils and cough syncope.
- Author
-
Larson SJ, Sances A Jr, Baker JB, and Reigel DH
- Subjects
- Cerebellar Diseases cerebrospinal fluid, Cerebellar Diseases complications, Cerebellar Diseases physiopathology, Cerebellar Diseases surgery, Cerebellum abnormalities, Cerebellum surgery, Cerebral Ventriculography, Electric Stimulation, Evoked Potentials, Headache etiology, Humans, Intracranial Pressure, Male, Median Nerve physiopathology, Middle Aged, Pneumoencephalography, Somatosensory Cortex physiopathology, Cerebellar Diseases congenital, Cough etiology, Syncope etiology
- Published
- 1974
- Full Text
- View/download PDF
35. [The monamine metabolites in the CSF of the patients with spinocerebellar degeneration and motor neuron disease (author's transl)].
- Author
-
Yamamoto M
- Subjects
- Adult, Aged, Humans, Middle Aged, Motor Neurons, Cerebellar Diseases cerebrospinal fluid, Homovanillic Acid cerebrospinal fluid, Hydroxyindoleacetic Acid cerebrospinal fluid, Neuromuscular Diseases cerebrospinal fluid, Phenylacetates cerebrospinal fluid
- Published
- 1980
36. [Cerebrospinal fluid methoxyhydroxy-phenylene glycol in Parkinson's disease and spinocerebellar degeneration (author's transl)].
- Author
-
Mizuno Y
- Subjects
- Humans, Nerve Degeneration, Cerebellar Diseases cerebrospinal fluid, Glycols cerebrospinal fluid, Methoxyhydroxyphenylglycol cerebrospinal fluid, Parkinson Disease cerebrospinal fluid, Spinal Cord Diseases cerebrospinal fluid
- Published
- 1979
37. [Epstein-Barr virus cerebellitis in an 11-year-old girl].
- Author
-
Cotton JB, Capdeville R, Abeille A, Grenier JL, and Nicolas A
- Subjects
- Acute Disease, Cerebellar Diseases cerebrospinal fluid, Child, Female, Herpesviridae Infections cerebrospinal fluid, Humans, Prognosis, Serologic Tests, Cerebellar Diseases diagnosis, Herpesviridae Infections diagnosis, Herpesvirus 4, Human
- Abstract
The authors report an eleven year old girl who manifested predominantly an acute cerebellar syndrome secondary to infection by Epstein Barr Virus. This complication is unusual and males are predominantly affected. The diagnostic and common physiopathological hypothesis are discussed.
- Published
- 1986
38. Levels of gamma-aminobutyric acid in cerebrospinal fluid in various neurologic disorders.
- Author
-
Manyam NV, Katz L, Hare TA, Gerber JC 3rd, and Grossman MH
- Subjects
- Brain Chemistry, Cerebellar Diseases cerebrospinal fluid, Creatine Kinase blood, Dementia cerebrospinal fluid, Diet, Encephalitis cerebrospinal fluid, Epilepsy cerebrospinal fluid, Humans, Huntington Disease cerebrospinal fluid, Hypoxia cerebrospinal fluid, Levodopa pharmacology, Multiple Sclerosis cerebrospinal fluid, Muscular Dystrophies blood, Nervous System Diseases metabolism, Parkinson Disease cerebrospinal fluid, Tissue Preservation, gamma-Aminobutyric Acid analysis, Nervous System Diseases cerebrospinal fluid, gamma-Aminobutyric Acid cerebrospinal fluid
- Abstract
Levels of gamma-aminobutyric acid (GABA) in CSF were measured by the ion exchange-fluorometric method in 136 patients who underwent evaluation for neurologic disorders. In 19 patients with no organic neurologic or mental disorders who acted as normal controls, the mean (+/-SD) GABA level in CSF was 239 +/- 76 picomoles/mL. Patients with acute hypoxic encephalopathy showed a mean GABA level in CSF higher than that of the controls, a difference that was statistically significant. In all the other disorders studied, the mean GABA level in CSF was either equal to or lower than that found in the controls. Statistically significant reductions of the GABA level in CSF were seen in patients with Huntington's disease, dementias, cerebellar cortical atrophy, multiple sclerosis, epilepsy, and Parkinson's disease.
- Published
- 1980
- Full Text
- View/download PDF
39. Alteration of amino acids in cerebrospinal fluid from patients with Parkinson's disease and spinocerebellar degeneration.
- Author
-
Araki K, Takino T, Ida S, and Kuriyama K
- Subjects
- Adult, Aged, Amino Acids metabolism, Cerebellar Diseases metabolism, Female, Headache cerebrospinal fluid, Headache metabolism, Humans, Male, Middle Aged, Parkinson Disease metabolism, Spinal Cord Diseases metabolism, Amino Acids cerebrospinal fluid, Cerebellar Diseases cerebrospinal fluid, Parkinson Disease cerebrospinal fluid, Spinal Cord Diseases cerebrospinal fluid
- Abstract
The alteration of amino acids in cerebrospinal fluids (CSF) from 14 cases of Parkinson's disease, five cases of cerebellar degeneration and five cases of headache (control) was studied using high performance liquid chromatography. In patients with Parkinson's disease, it was found that the CSF level of GABA showed a significant decrease, while that of taurine had an increase. The degree of disability in Parkinson's disease and the decreased GABA levels had a positive correlation, especially at its advanced stages. In patients with cerebellar degeneration, it was also found that there was a significant decrease in CSF GABA. The present results suggest that the CSF level of GABA may be a good indicator of the severity of Parkinson's disease as well as the presence of cerebellar degeneration. Possible involvement of the increase of CSF taurine in the pathogenesis of Parkinson's disease is also suggested.
- Published
- 1986
- Full Text
- View/download PDF
40. [Conference at the Salpêtrière. Progressive cerebellar astasia, tendinous areflexia, abnormal movements and inflammatory cerebrospinal fluid in a 77-year-old woman].
- Author
-
Lapresle J, Roullet E, and Gray F
- Subjects
- Aged, Cerebellar Diseases cerebrospinal fluid, Encephalomyelitis cerebrospinal fluid, Encephalomyelitis physiopathology, Female, Humans, Paraneoplastic Syndromes diagnosis, Poliomyelitis cerebrospinal fluid, Poliomyelitis physiopathology, Reflex, Stretch, Cerebellar Diseases diagnosis, Encephalomyelitis diagnosis, Movement Disorders etiology, Poliomyelitis diagnosis
- Published
- 1984
41. [HVA and 5-HIAA in the cerebrospinal fluid in extrapyramidal and cerebrellar syndromes. Preliminary data].
- Author
-
Carrieri P, Mandarini A, and Campanella G
- Subjects
- Adult, Aged, Female, Humans, Huntington Disease cerebrospinal fluid, Male, Middle Aged, Parkinson Disease cerebrospinal fluid, Basal Ganglia Diseases cerebrospinal fluid, Cerebellar Diseases cerebrospinal fluid, Homovanillic Acid cerebrospinal fluid, Hydroxyindoleacetic Acid cerebrospinal fluid, Phenylacetates cerebrospinal fluid
- Published
- 1975
42. Isoelectric focusing and electrophoresis of the CSF proteins in tremor of different origins.
- Author
-
Stibler H and Kjellin KG
- Subjects
- Adult, Aged, Beta-Globulins cerebrospinal fluid, Blood-Brain Barrier, Female, Humans, Hydrogen-Ion Concentration, Male, Middle Aged, Syndrome, gamma-Globulins cerebrospinal fluid, Alcoholism cerebrospinal fluid, Cerebellar Diseases cerebrospinal fluid, Cerebrospinal Fluid Proteins analysis, Electrophoresis, Paper, Isoelectric Focusing, Parkinson Disease cerebrospinal fluid, Tremor cerebrospinal fluid
- Abstract
The CSF proteins have previously been very little investigated in the cerebellar syndrome of chronic alcoholism and in essential tremor. Such studies have been carried out more thoroughly by electrophoretic methods in Parkinson's disease but generally with normal results. In the present investigation the CSF proteins were examined by isoelectric focusing and quantitative paper electrophoresis in 10 patients with the cerebellar syndrome of chronic alcoholsm, 12 patients with Parkinson's disease and 16 subjects with essential tremor. Abnormal CSF proteins of very similar appearance were found on isoelectric focusing in the acidic pH interval 5.6-5.8 in 80% of the patients with the cerebellar syndrome of chronic alcoholism. In Parkinson's disease the most common aberration was evidence of nonspecific blood-CSF-barrier damage which occurred in half of the patients. In only 17% of these cases did other alterations appear, situated in the pH range alkaline to pH 5.8. Abnormal CSF proteins were found in 94% of the patients with essential tremor. The aberrant proteins appeared in both the acidic and alkaline pH regions, most frequently with anisoelectric point at pH 5.9, 7.2 and 9.3. There was a considerably higher frequency of CSF protein abnormalities in different pH ranges in patients with tremor of more pronounced degree as compared to those with only mild symptoms. The electrophoretic examinations failed to show any conclusive alterations. Barrier-damage patterns of mild or moderate degree or slightly increased levels of CSF beta1-globulin were occasionally found in all 3 diseases. The results indicate that isoelectric focusing of the CSF proteins may be of diagnostic value in the cerebellar syndrome of chronic alcoholism and in essential tremor but does not reveal any characteristic abnormalities in Parkinson's disease.
- Published
- 1976
- Full Text
- View/download PDF
43. Gamma-aminobutyric acid (GABA) in cerebrospinal fluid.
- Author
-
Kuroda H
- Subjects
- Adult, Behcet Syndrome cerebrospinal fluid, Cerebellar Diseases cerebrospinal fluid, Cerebral Infarction cerebrospinal fluid, Dementia cerebrospinal fluid, Female, Humans, Huntington Disease cerebrospinal fluid, Male, Meningitis cerebrospinal fluid, Parkinson Disease cerebrospinal fluid, Radioligand Assay, gamma-Aminobutyric Acid cerebrospinal fluid
- Abstract
Levels of gamma-aminobutyric acid (GABA) in cerebrospinal fluid (CSF) were measured by radioreceptor assay (RRA) in 25 normal controls and in 121 patients with various central nervous system disorders. CSF-GABA levels could be measured down to 5 pmoles/ml reliably by this assay. In normal controls, the mean (+/- SEM) GABA level in CSF was 127 +/- 5.2 pmoles/ml. There was no correlation between age, sex and the CSF-GABA level in normal controls. The lowest CSF-GABA level, which was 60 +/- 6.0 pmoles/ml, was observed in alcoholic patients suffering from cerebellar ataxia. The CSF-GABA levels were quite low in patients with Alzheimer's disease, late cortical cerebellar atrophy, neuro-Behçet's syndrome, olivopontocerebellar atrophy, Huntington's chorea, Parkinson's disease and cerebral hemorrhage. On the other hand, the CSF-GABA levels of meningitis patients were significantly increased. These findings suggest that measuring the CSF-GABA level is quite beneficial in the diagnosis and pathophysiological determinations of some diseases.
- Published
- 1983
- Full Text
- View/download PDF
44. Anticerebellar antibodies in serum and cerebrospinal fluid of a patient with oat cell carcinoma of the lung and paraneoplastic cerebellar degeneration.
- Author
-
Greenlee JE and Lipton HL
- Subjects
- Antibodies cerebrospinal fluid, Carcinoma, Small Cell blood, Carcinoma, Small Cell cerebrospinal fluid, Cerebellar Diseases blood, Cerebellar Diseases cerebrospinal fluid, Cerebellar Diseases pathology, Cerebellum pathology, Fluorescent Antibody Technique, Humans, Lung Neoplasms blood, Lung Neoplasms cerebrospinal fluid, Male, Middle Aged, Paraneoplastic Syndromes blood, Paraneoplastic Syndromes cerebrospinal fluid, Antibodies analysis, Carcinoma, Small Cell immunology, Cerebellar Diseases immunology, Cerebellum immunology, Lung Neoplasms immunology, Nerve Degeneration, Paraneoplastic Syndromes immunology
- Abstract
A 56-year-old man was seen with subacute cerebellar degeneration and was found to have oat cell carcinoma of the lung. Antibodies to cerebellar Purkinje cells and granule cells were detected in both serum and cerebrospinal fluid (CSF), and intrathecal antibody synthesis was suggested by serum CSF antibody ratios, CSF IgG index, and CSF IgG synthesis rate. The patient's condition improved slightly with plasmapheresis, corticosteroids, and therapy of his underlying tumor, but he continued to exhibit a severe cerebellar deficit until his death more than one year later. Paraneoplastic cerebellar degeneration may be accompanied by synthesis of anticerebellar antibodies, both systemically and within the central nervous system.
- Published
- 1986
- Full Text
- View/download PDF
45. [Cerebrospinal fluid homovanillic acid in paralysis agitans and spinocerebellar degeneration (author's transl)].
- Author
-
Mizuno Y and Ariga T
- Subjects
- Humans, Cerebellar Diseases cerebrospinal fluid, Homovanillic Acid cerebrospinal fluid, Parkinson Disease cerebrospinal fluid, Phenylacetates cerebrospinal fluid, Spinal Cord Diseases cerebrospinal fluid
- Published
- 1979
46. [Central metabolism of dopamine and serotonin. II. Significance of cerebrospinal fluid HVA and 5-HIAA changes in extrapyramidal and cerebellar syndromes].
- Author
-
Buscaino GA, Mandarini A, Campanella G, Carrieri P, and Orefice G
- Subjects
- Humans, Metoclopramide, Probenecid, Basal Ganglia Diseases cerebrospinal fluid, Brain metabolism, Cerebellar Diseases cerebrospinal fluid, Dopamine metabolism, Epilepsy cerebrospinal fluid, Homovanillic Acid cerebrospinal fluid, Huntington Disease cerebrospinal fluid, Hydroxyindoleacetic Acid cerebrospinal fluid, Parkinson Disease cerebrospinal fluid, Phenylacetates cerebrospinal fluid, Serotonin metabolism
- Published
- 1976
47. Effect of probenecid on levels of cyclic AMP in human cerebrospinal fluid.
- Author
-
Cramer H, Ng LK, and Chase TN
- Subjects
- Adult, Aged, Cerebellar Diseases cerebrospinal fluid, Female, Humans, Male, Middle Aged, Muscular Diseases cerebrospinal fluid, Parkinson Disease cerebrospinal fluid, Spinal Cord Diseases cerebrospinal fluid, Cyclic AMP cerebrospinal fluid, Probenecid pharmacology
- Published
- 1972
- Full Text
- View/download PDF
48. The CSF iron in patients with neurological diseases.
- Author
-
Kjellin KG
- Subjects
- Adult, Aged, Alcoholism cerebrospinal fluid, Amyotrophic Lateral Sclerosis cerebrospinal fluid, Centrifugation, Cerebellar Ataxia cerebrospinal fluid, Cerebellar Diseases cerebrospinal fluid, Craniocerebral Trauma cerebrospinal fluid, Dementia cerebrospinal fluid, Female, Hemoglobins cerebrospinal fluid, Humans, Huntington Disease cerebrospinal fluid, Hypertension cerebrospinal fluid, Male, Middle Aged, Multiple Sclerosis cerebrospinal fluid, Muscular Atrophy cerebrospinal fluid, Parkinson Disease cerebrospinal fluid, Polyradiculopathy cerebrospinal fluid, Porphyrias cerebrospinal fluid, Spectrophotometry, Spinal Cord Diseases cerebrospinal fluid, Spinal Cord Neoplasms cerebrospinal fluid, Subarachnoid Hemorrhage cerebrospinal fluid, Torticollis cerebrospinal fluid, Cerebral Hemorrhage cerebrospinal fluid, Cerebrospinal Fluid Proteins analysis, Iron cerebrospinal fluid, Nervous System Diseases cerebrospinal fluid
- Published
- 1967
- Full Text
- View/download PDF
49. [Cytology of the cerebrospinal fluid].
- Author
-
Dietrichson P
- Subjects
- Cerebellar Diseases diagnosis, Child, Preschool, Follow-Up Studies, Humans, Infant, Infant, Newborn, Paresis cerebrospinal fluid, Prognosis, Cerebellar Diseases cerebrospinal fluid, Cerebrovascular Disorders cerebrospinal fluid, Multiple Sclerosis cerebrospinal fluid
- Published
- 1973
50. Problems in cerebellar hemorrhage and infarction.
- Author
-
Norris JW, Eisen AA, and Branch CL
- Subjects
- Adolescent, Adult, Aged, Anticoagulants therapeutic use, Cerebellar Diseases cerebrospinal fluid, Cerebellar Diseases drug therapy, Cerebellar Diseases etiology, Cerebral Hemorrhage cerebrospinal fluid, Cerebral Hemorrhage drug therapy, Cerebral Hemorrhage etiology, Cerebral Ventriculography, Cerebrovascular Disorders cerebrospinal fluid, Cerebrovascular Disorders diagnosis, Diagnosis, Differential, Female, Humans, Hypertension complications, Infarction, Male, Middle Aged, Prognosis, Cerebellar Diseases diagnosis, Cerebral Hemorrhage diagnosis
- Published
- 1969
- Full Text
- View/download PDF
Catalog
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