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306 results on '"Chaudhry, Afzal"'

3. Exploring the immunological relevance of pre‐transplant donor‐specific antibody in intestinal transplantation, with special consideration to the liver.

Author

McArdle, Rhea, Cope, Rebecca, Chaudhry, Afzal, Sharkey, Lisa, and Peacock, Sarah

Subjects
SURVIVAL analysis (Biometry), HLA histocompatibility antigens, IMMUNOGLOBULINS, OVERALL survival, INTESTINES, TREATMENT effectiveness, LIVER
Abstract

Despite recent advances that have improved outcomes following intestinal transplantation (ITx), achieving long‐term patient survival and rejection‐free survival is still challenging. Understanding the relevance of pre‐transplant human leukocyte antigen (HLA) donor‐specific antibody (DSA) in ITx and the immunomodulatory potential of the liver within the allograft is crucial to providing an accurate assessment of pre‐transplant immunological risk, which could influence and improve post‐transplant outcomes further. This was the primary objective of this retrospective study of 95 adult ITx transplants which took place at Cambridge University Hospitals (United Kingdom) between 2007 and 2019. Two novel programs were developed and validated to identify DSA (tested by Luminex single antigen beads) in this dataset. Data analysis utilised Kaplan–Meier survival methods, and statistical analysis was performed using log‐rank tests and adjusted Cox models. Fifty‐four (57%) ITx cases contained a liver, and 36 (38%) were sensitised to HLA. Pre‐transplant DSA > 500 mean fluorescent intensity appeared to negatively affect post‐ITx patient survival and rejection outcomes. Additionally, liver‐inclusive allografts seemed to show particular resistance to HLA class I DSA. Our data hints towards consistency with other ITx studies where deleterious effects of DSA have been demonstrated, and where liver inclusion is protective from HLA class I DSA. This is in line with current national guidelines for immunological risk. Our publicly available research programs could support future large or multicentre studies where statistically relevant data might be gained. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Impact of the COVID-19 pandemic on routine surveillance for adults with chronic hepatitis B virus (HBV) infection in the UK

Author

Campbell, Cori, primary, Wang, Tingyan, additional, Smith, David A., additional, Freeman, Oliver, additional, Noble, Theresa, additional, Várnai, Kinga A, additional, Harris, Steve, additional, Salih, Hizni, additional, Roadknight, Gail, additional, Little, Stephanie, additional, Glampson, Ben, additional, Mercuri, Luca, additional, Papadimitriou, Dimitri, additional, Jones, Christopher R, additional, Taylor, Vince, additional, Chaudhry, Afzal, additional, Phan, Hang, additional, Borca, Florina, additional, Olza, Josune, additional, Warricker, Frazer, additional, Romão, Luis, additional, Ramlakhan, David, additional, English, Louise, additional, Klenerman, Paul, additional, Andersson, Monique I., additional, Collier, Jane, additional, Nastouli, Eleni, additional, Khakoo, Salim I., additional, Gelson, William, additional, Cooke, Graham S., additional, Woods, Kerrie, additional, Davies, Jim, additional, Barnes, Eleanor, additional, and Matthews, Philippa C., additional

Published
2023
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7. Distinct virologic trajectories in chronic hepatitis B patients identify heterogeneity in response to nucleotide analogue therapy

Author

Wang, Tingyan, primary, Campbell, Cori, additional, Roadknight, Gail, additional, Little, Stephanie, additional, Stockdale, Alexander, additional, Todd, Stacy, additional, McIntyre, Karl, additional, Frankland, Andrew, additional, Jaworski, Jakub, additional, Chaudhry, Afzal, additional, Glampson, Ben, additional, Mercuri, Luca, additional, Papadimitriou, Dimitri, additional, Jones, Christopher R., additional, Varnai, Kinga, additional, Noble, Theresa, additional, Salih, Hizni, additional, Davis, Cai, additional, Heinson, Ashley, additional, George, Michael, additional, Borca, Florina, additional, Olza, Josune, additional, English, Louise, additional, Romão, Luis, additional, Ramlakhan, David, additional, Nastouli, Eleni, additional, Khakoo, Salim, additional, Gelson, Will, additional, Cooke, Graham, additional, Woods, Kerrie, additional, Davies, Jim, additional, Matthews, Philippa, additional, and Barnes, Eleanor, additional

Published
2023
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15. Moving from non-emergency bleeps and long-range pagers to a hospital-wide, EHR-integrated secure messaging system: an implementer report

Author

Ercole, Ari, Tolliday, Claire, Gelson, William, Rudd, James HF, Cameron, Ewen, Chaudhry, Afzal, Hamer, Fiona, Davies, Justin, Ercole, Ari [0000-0001-8350-8093], and Apollo - University of Cambridge Repository

Subjects
Tertiary Care Centers, Electronic Health Records, Humans, Patient Safety, Information Technology, State Medicine
Abstract

INTRODUCTION: Obsolete bleep/long-range pager equipment remains firmly embedded in the National Health Service (NHS). OBJECTIVE: To introduce a secure, chart-integrated messaging system (Epic Secure Chat) in a large NHS tertiary referral centre to replace non-emergency bleeps/long-range pagers. METHODS: The system was socialised in the months before go-live. Operational readiness was overseen by an implementation group with stakeholder engagement. Cutover was accompanied by a week of Secure Chat and bleeps running in parallel. RESULTS: Engagement due to socialisation was high with usage stabilising approximately 3 months after go-live. Contact centre internal call activity fell significantly after go-live. No significant patient safety concerns were reported. DISCUSSION: Uptake was excellent with substantial utilisation well before cutover indirectly supporting high levels of engagement. The majority of those who previously carried bleeps were content to use personal devices for messaging because of user convenience after reassurance about privacy. CONCLUSION: An integrated secure messaging system can replace non-emergency bleeps with beneficial impact on service.

Published
2023

16. Pharmacogenomic alerts: Developing guidance for use by healthcare professionals

Author

Carter, John-Paul L, Critchlow, James, Jackson, Sarah, Sanghvi, Sonali, Feger, Helene, Chaudhry, Afzal, Foley, Lorraine, Sofat, Reecha, Carter, John-Paul L [0000-0002-2284-3362], Sanghvi, Sonali [0000-0002-1937-5430], Sofat, Reecha [0000-0002-0242-6115], and Apollo - University of Cambridge Repository

Subjects
pharmacogenomics, Pharmacology, electronic health records, Pharmacogenetics, Health Personnel, genomics, Humans, Pharmacology (medical), Delivery of Health Care, alerts
Abstract

Funder: NHS England; Id: http://dx.doi.org/10.13039/100013963, Funder: NIHR UCLH Biomedical Centre; Id: http://dx.doi.org/10.13039/501100012317, AIMS: For diseases with a genetic cause, genomics can deliver improved diagnostics and facilitate access to targeted treatments. Drug pharmacodynamics and pharmacokinetics are often dependent on genetic variation underlying these processes. As pharmacogenomics comes of age, it may be the first way in which genomics is utilised at a population level. Still required is guidance and standards of how genomic information can be communicated within the health record, and how clinicians should be alerted to variation impacting the use of medicines. METHODS: The Professional Record Standards Body commissioned by NHS England developed guidance on using pharmacogenomics information in clinical practice. We conducted research with those implementing pharmacogenomics in England and internationally to produce guidance and recommendations for a systems-based approach. RESULTS: A consensus viewpoint is that systems need to be in place to ensure the safe provision of pharmacogenomics information that is curated, actionable and up-to-date. Standards should be established with respect to notification and information exchange, which could impact new or existing prescribing and these must be in keeping with routine practice. Alerting systems should contribute to safer practices. CONCLUSION: Ensuring pharmacogenetics information is available to make safer use of medicines will require a major effort, of which this guidance is a beginning. Standards are required to ensure useful genomic information within the health record can be communicated to clinicians in the right format and at the right times to be actioned successfully. A multidisciplinary group of stakeholders must be engaged in developing pharmacogenomic standards to support the most appropriate prescribing.

Published
2022

18. A prospective study of risk factors associated with seroprevalence of SARS-CoV-2 antibodies in healthcare workers at a large UK teaching hospital

Author

Cooper, Daniel J, primary, Lear, Sara, additional, Watson, Laura, additional, Shaw, Ashley, additional, Ferris, Mark, additional, Doffinger, Rainer, additional, Bousfield, Rachel, additional, Sharrocks, Katherine, additional, Weekes, Michael P., additional, Warne, Ben, additional, Sparkes, Dominic, additional, Jones, Nick K, additional, Rivett, Lucy, additional, Routledge, Matthew, additional, Chaudhry, Afzal, additional, Dempsey, Katherine, additional, Matson, Montgomery, additional, Lakha, Adil, additional, Gathercole, George, additional, O'Connor, Olivia, additional, Wilson, Emily, additional, Shahzad, Orthi, additional, Toms, Kieran, additional, Thompson, Rachel, additional, Halsall, Ian, additional, Halsall, David, additional, Houghton, Sally, additional, Papadia, Sofia, additional, Kingston, Nathalie, additional, Stirrups, Kathleen E, additional, Graves, Barbara, additional, Townsend, Paul, additional, Walker, Neil, additional, Stark, Hannah, additional, De Angelis, Daniela, additional, Seaman, Shaun, additional, Dougan, Gordon, additional, Bradley, John R, additional, Török, M. Estée, additional, Goodfellow, Ian, additional, and Baker, Stephen, additional

Published
2022
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19. A prospective study of risk factors associated with seroprevalence of SARS-CoV-2 antibodies in healthcare workers at a large UK teaching hospital

Author

Cooper, Daniel J, Lear, Sara, Watson, Laura, Shaw, Ashley, Ferris, Mark, Doffinger, Rainer, Bousfield, Rachel, Sharrocks, Katherine, Weekes, Michael P, Warne, Ben, Sparkes, Dominic, Jones, Nick K, Rivett, Lucy, Routledge, Matthew, Chaudhry, Afzal, Dempsey, Katherine, Matson, Montgomery, Lakha, Adil, Gathercole, George, O'Connor, Olivia, Wilson, Emily, Shahzad, Orthi, Toms, Kieran, Thompson, Rachel, Halsall, Ian, Halsall, David, Houghton, Sally, Papadia, Sofia, Kingston, Nathalie, Stirrups, Kathleen E, Graves, Barbara, Townsend, Paul, Walker, Neil, Stark, Hannah, CITIID-NIHR BioResource COVID-19 Collaboration, De Angelis, Daniela, Seaman, Shaun, Dougan, Gordon, Bradley, John R, Török, M Estée, Goodfellow, Ian, Baker, Stephen, Matson, Montgomery [0000-0002-1609-5361], Apollo - University of Cambridge Repository, Jones, Nicholas Keith [0000-0003-4475-7761], De Angelis, Daniela [0000-0001-6619-6112], and Seaman, Shaun [0000-0003-3726-5937]

Subjects
SARS-CoV-2, healthcare workers, Risk Factors, Seroepidemiologic Studies, sero-epidemiology, Health Personnel, COVID-19, Humans, risk factor analysis, Prospective Studies, Antibodies, Viral, Hospitals, Teaching, United Kingdom
Abstract

OBJECTIVES: To describe the risk factors for SARS-CoV-2 infection in UK healthcare workers (HCWs). METHODS: We conducted a prospective sero-epidemiological study of HCWs at a major UK teaching hospital using a SARS-CoV-2 immunoassay. Risk factors for seropositivity were analysed using multivariate logistic regression. RESULTS: 410/5,698 (7·2%) staff tested positive for SARS-CoV-2 antibodies. Seroprevalence was higher in those working in designated COVID-19 areas compared with other areas (9·47% versus 6·16%) Healthcare assistants (aOR 2·06 [95%CI 1·14-3·71]; p=0·016) and domestic and portering staff (aOR 3·45 [95% CI 1·07-11·42]; p=0·039) had significantly higher seroprevalence than other staff groups after adjusting for age, sex, ethnicity and COVID-19 working location. Staff working in acute medicine and medical sub-specialities were also at higher risk (aOR 2·07 [95% CI 1·31-3·25]; p

Published
2022

20. Conclusion

Author

Chaudhry, Afzal, Kleinpoppen, Hans, Chaudhry, Afzal, and Kleinpoppen, Hans

Published
2011
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21. Cohort Profile: The National Institute for Health Research Health Informatics Collaborative: Hepatitis B Virus (NIHR HIC HBV) research dataset

Author

Wang, Tingyan, primary, Smith, David A, additional, Campbell, Cori, additional, Freeman, Oliver, additional, Moysova, Zuzana, additional, Noble, Theresa, additional, Várnai, Kinga A, additional, Harris, Steve, additional, Salih, Hizni, additional, Roadknight, Gail, additional, Little, Stephanie, additional, Glampson, Ben, additional, Mercuri, Luca, additional, Papadimitriou, Dimitri, additional, Jones, Christopher R, additional, Taylor, Vince, additional, Chaudhry, Afzal, additional, Phan, Hang, additional, Borca, Florina, additional, Olza, Josune, additional, Warricker, Frazer, additional, Romão, Luis, additional, Ramlakhan, David, additional, English, Louise, additional, Klenerman, Paul, additional, Andersson, Monique, additional, Collier, Jane, additional, Stockdale, Alexander J, additional, Todd, Stacy, additional, McIntyre, Karl, additional, Frankland, Andrew, additional, Nastouli, Eleni, additional, Khakoo, Salim I, additional, Gelson, William, additional, Cooke, Graham S, additional, Woods, Kerrie, additional, Davies, Jim, additional, Barnes, Eleanor, additional, and Matthews, Philippa C, additional

Published
2022
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22. Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

Author

Aggarwal, Dinesh, Warne, Ben, Jahun, Aminu S., Hamilton, William L., Fieldman, Thomas, du Plessis, Louis, Hill, Verity, Blane, Beth, Watkins, Emmeline, Wright, Elizabeth, Hall, Grant, Ludden, Catherine, Myers, Richard, Hosmillo, Myra, Chaudhry, Yasmin, Pinckert, Malte L., Georgana, Iliana, Izuagbe, Rhys, Leek, Danielle, Nsonwu, Olisaeloka, Hughes, Gareth J., Packer, Simon, Page, Andrew J., Metaxaki, Marina, Fuller, Stewart, Weale, Gillian, Holgate, Jon, Brown, Christopher A., Orton, Alexandra, Douthwaite, Julie, Rees, Steve, Brown, Christopher, Clark, Roger, Jones, Daniel R., Kuenzi, Fred, Rankin, Jennifer, Waddell, Ian, Maxwell, Patrick, Matheson, Nicholas, Abell, Chris, Braithwaite, Vickie, Brierley, Craig, Crowcroft, Jon, Dahal, Aastha, Faulkner, Kathryn, Glover, Michael, Goodfellow, Ian, Greatorex, Jane, James, Laura, Lehner, Paul, Leslie, Ian, Liddell, Kathleen, Margolis, Ben, Morgan, Sally, Sheridan, Linda, Valletta, Sally, Vignoles, Anna, Vinnell, Martin, Wills, Mark, Hilborne, Sarah, Berry, Sarah, Kahkeshi, Mahin Bagheri, Hancock, Dawn, Winster, Jennifer, Enright, Jessica, Samworth, Richard, Samtani, Vijay, Ahmadi-Assalemi, Gabriela, Feather, Tom, Goodall, Robin, Hoensch, Steve, Johnson, Dean, Hunt, Martin, Mathieson, Nick, Nikitina, Katya, Sheldrake, Zara, Keen, Martin, Sato, Aris, Connor, David, Tolhurst, Jonathan, Williman, Jack, Hollamby, Victoria, Jordan, Sinead, Fatseas, Tania, Taylor, Peter, Georgiou, Christine, Caspersz, Michelle, McNulty, Claire, Davies, Richard, Clarke, Rebecca, Danaei, Darius, Dyer, Rory, Glew, Rob, Lambson, Oliver, Gibbs, Karen, Mozdzen, Barbara, Raub, Gabor, Radecki, Asako, White, Phil, Hughes, Robert, Gransden, Lucie, Ceaser, Matt, Sing, Robert, Wilson, Karl, Parlikad, Ajith, Dhada, Maharshi, Ridgman, Tom, Mungovan, Diane, Matthews, Steve, Searle, Paul, Mills, John, Neely, Andy, Henderson, Robert, Murphy, Edna, Russell, Matthew, Freeling, Anthony, Poppitt, Steve, Tynan, Jo, Knapton, James, Marchetti, Filippo, Angelis, Daniela De, Feltwell, Theresa, Hadjirin, Nazreen F., Jahun, Aminu, Pinckert, Malte, Shaw, Ashley, Chaudhry, Afzal, Brown, Nicholas M., Mactavous, Lenette, Hannan, Sophie, Hosaja, Aleksandra, Leong, Clare, Wright, Jo, Quinnell, Natalie, Workman, Chris, Ferris, Mark, Wright, Giles, Brooks, Ellena, Carabelli, Alessandro M., Churcher, Carol M., Galai, Katerina, Girgis, Sophia T., Gupta, Ravi K., McManus, Georgina M., Palmer, Sophie, Peacock, Sharon J., Smith, Kim S., Allara, Elias, Bibby, David, Bishop, Chloe, Bosworth, Andrew, Bradshaw, Daniel, Chalker, Vicki, Chand, Meera, Dabrera, Gavin, Ellaby, Nicholas, Gallagher, Eileen, Groves, Natalie, Harrison, Ian, Hartman, Hassan, Hopes, Richard, Hubb, Jonathan, Hutchings, Stephanie, Lackenby, Angie, Ledesma, Juan, Lee, David, Manesis, Nikos, Manso, Carmen, Mbisa, Tamyo, Miah, Shahjahan, Muir, Peter, Osman, Husam, Patel, Vineet, Pearson, Clare, Platt, Steven, Pymont, Hannah M., Ramsay, Mary, Robinson, Esther, Schaefer, Ulf, Thornton, Alicia, Twohig, Katherine A., Vipond, Ian B., Williams, David, Aigrain, Louise, Alderton, Alex, Amato, Roberto, Ariani, Cristina V., Barrett, Jeff, Bassett, Andrew R., Beale, Mathew A., Beaver, Charlotte, Bellis, Katherine L., Betteridge, Emma, Bonfield, James, Bronner, Iraad F., Chapman, Michael H. S., Danesh, John, Davies, Robert, Dorman, Matthew J., Drury, Eleanor, Durham, Jillian, Farr, Ben W., Foulser, Luke, Goncalves, Sonia, Goodwin, Scott, Gourtovaia, Marina, Jackson, David K., James, Keith, Jamrozy, Dorota, Johnston, Ian, Kane, Leanne, Kay, Sally, Keatley, Jon-Paul, Kwiatkowski, Dominic, Langford, Cordelia F., Lawniczak, Mara, Lensing, Stefanie V., Leonard, Steven, Letchford, Laura, Lewis, Kevin, Liddle, Jennifier, Livett, Rich, Lo, Stephanie, Makunin, Alex, Martincorena, Inigo, McCarthy, Shane, McGuigan, Samantha, Moll, Robin J., Nelson, Rachel, Oliver, Karen, Palmer, Steve, Park, Naomi R., Patel, Minal, Prestwood, Liam, Puethe, Christoph, Quail, Michael A., Rajan, Diana, Rajatileka, Shavanthi, Redshaw, Nicholas M., Scott, Carol, Shirley, Lesley, Sillitoe, John, Thurston, Scott A. J., Tonkin-Hill, Gerry, Tovar-Corona, Jaime M., Weldon, Danni, Whitwham, Andrew, Attwood, Stephen W., Zamudio, Marina Escalera, Francois, Sarah, Gutierrez, Bernardo, Kraemer, Moritz U. G., Raghwani, Jayna, Vasylyeva, Tetyana I., Zarebski, Alex E., Alikhan, Nabil-Fareed, Aydin, Alp, Baker, David J., de Oliveira Martins, Leonardo, Kay, Gemma L., Le-Viet, Thanh, Mather, Alison E., Meadows, Lizzie, O’Grady, Justin, Rudder, Steven, Trotter, Alexander J., Illingworth, Chris J., Jackson, Chris, Aranday-Cortes, Elihu, Asamaphan, Patawee, Broos, Alice, Carmichael, Stephen N., da Silva Filipe, Ana, Hughes, Joseph, Jesudason, Natasha G., Johnson, Natasha, Li, Kathy K., Mair, Daniel, Nichols, Jenna, Nickbakhsh, Seema, Niebel, Marc O., Nomikou, Kyriaki, Orton, Richard J., Robertson, David L., Shah, Rajiv N., Shepherd, James G., Singer, Joshua B., Starinskij, Igor, Thomson, Emma C., Tong, Lily, Vattipally, Sreenu, Ash, Amy, Koshy, Cherian, Cortes, Nick, Kidd, Stephen, Lynch, Jessica, Moore, Nathan, Mori, Matilde, Wise, Emma, Curran, Tanya, Fairley, Derek J., McKenna, James P., Adams, Helen, Bonsall, David, Fraser, Christophe, Golubchik, Tanya, Cogger, Benjamin J., Hassan-Ibrahim, Mohammed O., Malone, Cassandra S., Reynolds, Nicola, Wantoch, Michelle, Afifi, Safiah, Beer, Robert, John, Michaela, Maksimovic, Joshua, McCluggage, Kathryn, Morgan, Sian, Spellman, Karla, Bresner, Catherine, Connor, Thomas R., Fuller, William, Guest, Martyn, Gulliver, Huw, Kitchen, Christine, Marchbank, Angela, Merrick, Ian, Munn, Robert, Price, Anna, Southgate, Joel, Workman, Trudy, Patel, Amita, Snell, Luke B., Batra, Rahul, Charalampous, Themoula, Edgeworth, Jonathan, Nebbia, Gaia, Beckett, Angela H., Robson, Samuel C., Aanensen, David M., Abudahab, Khalil, Menegazzo, Mirko, Taylor, Ben E. W., Underwood, Anthony P., Yeats, Corin A., Berry, Louise, Boswell, Tim, Clark, Gemma, Fleming, Vicki M., Howson-Wells, Hannah C., Jones, Carl, Joseph, Amelia, Khakh, Manjinder, Lister, Michelle M., Smith, Wendy, Willingham, Iona, Bird, Paul, Fallon, Karlie, Helmer, Thomas, Holmes, Christopher, Tang, Julian, Blakey, Victoria, Campbell, Sharon, Raviprakash, Veena, Sheriff, Nicola, Williams, Lesley-Anne, Carlile, Matthew, Debebe, Johnny, Holmes, Nadine, Loose, Matthew W., Moore, Christopher, Sang, Fei, Wright, Victoria, Coll, Francesc, Betancor, Gilberto, Signell, Adrian W., Wilson, Harry D., Davis, Thomas, Eldirdiri, Sahar, Kenyon, Anita, Torok, M. Estee, Lowe, Hannah, Moses, Samuel, Bedford, Luke, Moore, Jonathan, Stonehouse, Susanne, Awan, Ali R., Fisher, Chloe L., BoYes, John, Atkinson, Laura, Breuer, Judith, Brown, Julianne R., Harris, Kathryn A., Lee, Jack C. D., Shah, Divya, Storey, Nathaniel, Flaviani, Flavia, Alcolea-Medina, Adela, Vernet, Gabrielle, Williams, Rebecca, Chapman, Michael R., Chatterton, Wendy, Heaney, Judith, Levett, Lisa J., Pusok, Monika, Xu-McCrae, Li, Bashton, Matthew, Smith, Darren, Young, Greg, Bolt, Frances, Cox, Alison, Holmes, Alison, Madona, Pinglawathee, Mookerjee, Siddharth, Price, James, Randell, Paul A., Boyd, Olivia, Nascimento, Fabricia F., Geidelberg, Lily, Johnson, Rob, Jorgensen, David, Ragonnet-Cronin, Manon, Rowan, Aileen, Siveroni, Igor, Taylor, Graham P., Volz, Erik M., Smollett, Katherine L., Loman, Nicholas J., McMurray, Claire, McNally, Alan, Nicholls, Sam, Poplawski, Radoslaw, Quick, Joshua, Rowe, Will, Stockton, Joanne, Nunez, Rocio T. Martinez, Breen, Cassie, Cowell, Angela, Mason, Jenifer, O’Toole, Elaine, Robinson, Trevor I., Watts, Joanne, Sluga, Graciela, Ahmad, Shazaad S. Y., George, Ryan P., Machin, Nicholas W., Halstead, Fenella, Hogsden, Wendy, Sivaprakasam, Venkat, Carden, Holli, Hale, Antony D., Harper, Katherine L., Macfarlane-Smith, Louissa R., Burton-Fanning, Shirelle, Collins, Jennifer, Eltringham, Gary, Payne, Brendan AI., Taha, Yusri, Waugh, Sheila, O’Brien, Sarah, Rushton, Steven, Blacow, Rachel, Bradley, Amanda, Maclean, Alasdair, Mollett, Guy, Dewar, Rebecca, McHugh, Martin P., Templeton, Kate E., Wastenge, Elizabeth, Coupland, Lindsay, Dervisevic, Samir, Meader, Emma J., Stanley, Rachael, Smith, Louise, Barton, Edward, Graham, Clive, Padgett, Debra, Scott, Garren, Greenaway, Jane, Swindells, Emma, McCann, Clare, Nelson, Andrew, Yew, Wen Chyin, Andersson, Monique, Crook, Derrick, Eyre, David, Justice, Anita, Peto, Timothy, Duckworth, Nichola, Sloan, Tim J., Walsh, Sarah, Bicknell, Kelly, Chauhan, Anoop J., Elliott, Scott, Glaysher, Sharon, Impey, Robert, Lloyd, Allyson, Wyllie, Sarah, Levene, Nick, Monaghan, Lynn, Bradley, Declan T., Wyatt, Tim, Curran, Martin D., Parmar, Surendra, Holden, Matthew T. G., Shaaban, Sharif, Adams, Alexander, Asad, Hibo, Birchley, Alec, Bull, Matthew, Coombes, Jason, Corden, Sally, Cottrell, Simon, Craine, Noel, Cronin, Michelle, Davies, Alisha, Lacy, Elen De, Downing, Fatima, Edwards, Sue, Evans, Johnathan M., Fina, Laia, Gaskin, Amy, Gatica-Wilcox, Bree, Gifford, Laura, Gilbert, Lauren, Graham, Lee, Heyburn, David, Hilvers, Ember, Howe, Robin, Jones, Hannah, Jones, Rachel, Jones, Sophie, Kumziene-SummerhaYes, Sara, McKerr, Caoimhe, Moore, Catherine, Morgan, Mari, Pacchiarini, Nicole, Perry, Malorie, Plimmer, Amy, Rey, Sara, Shankar, Giri, Taylor, Sarah, Watkins, Joanne, Williams, Chris, Casey, Anna, Ratcliffe, Liz, Acheson, Erwan, Molnar, Zoltan, Simpson, David A., Thompson, Thomas, Auckland, Cressida, Ellard, Sian, Jones, Christopher R., Knight, Bridget A., Masoli, Jane A. H., Haque, Tanzina, Hart, Jennifer, Irish-Tavares, Dianne, Mahungu, Tabitha W., Witele, Eric, Dadrah, Ashok, Fenton, Melisa L., Saluja, Tranprit, Symmonds, Amanda, Bourgeois, Yann, Scarlett, Garry P., Cook, Kate, Dent, Hannah, Fearn, Christopher, Goudarzi, Salman, Loveson, Katie F., Paul, Hannah, Evans, Cariad, Johnson, Kate, Partridge, David G., Raza, Mohammad, Baker, Paul, Bonner, Stephen, Essex, Sarah, Liggett, Steven, Lyons, Ronan A., Mahanama, Adhyana I. K., Saeed, Kordo, Samaraweera, Buddhini, Silveira, Siona, Wilson-Davies, Eleri, Emanuela, P., Bayzid, Nadua, Cotic, Marius, Ensell, Leah, Hartley, John A., Jannoo, Riaz, Karamani, Angeliki, Kristiansen, Mark, Lowe, Helen L., Roy, Sunando, Westhorpe, Adam P., Williams, Rachel J., Williams, Charlotte A., Jeremiah, Sarah, Prieto, Jacqui A., Berry, Lisa, Grammatopoulos, Dimitris, Jones, Katie, Pandey, Sarojini, Beggs, Andrew, Richter, Alex, Ashcroft, Fiona, Best, Angus, Crawford, Liam, Cumley, Nicola, Mayhew, Megan, Megram, Oliver, Mirza, Jeremy, Moles-Garcia, Emma, Percival, Benita, Bucca, Giselda, Hesketh, Andrew R., Smith, Colin P., Davidson, Rose K., Balcazar, Carlos E., Gallagher, Michael D., O’Toole, Áine, Rambaut, Andrew, Rooke, Stefan, Stanton, Thomas D., Williams, Thomas, Williamson, Kathleen A., Bewshea, Claire M., Farbos, Audrey, Harrison, James W., Jeffries, Aaron R., Manley, Robin, Michell, Stephen L., Michelsen, Michelle L., Sambles, Christine M., Studholme, David J., Temperton, Ben, Warwick-Dugdale, Joanna, Darby, Alistair C., Eccles, Richard, Gemmell, Matthew, Gregory, Richard, Haldenby, Sam T., Hiscox, Julian A., Hughes, Margaret, Iturriza-Gomara, Miren, Jackson, Kathryn A., Lucaci, Anita O., Nelson, Charlotte, Paterson, Steve, Rainbow, Lucille, Turtle, Lance, Vamos, Edith E., Webster, Hermione J., Whitehead, Mark, Wierzbicki, Claudia, Angyal, Adrienn, Brown, Rebecca, de Silva, Thushan I., Freeman, Timothy M., Gallis, Marta, Green, Luke R., Groves, Danielle C., Keeley, Alexander J., Lindsey, Benjamin B., Louka, Stavroula F., Parker, Matthew D., Parsons, Paul J., Smith, Nikki, Tucker, Rachel M., Wang, Dennis, Whiteley, Max, Wyles, Matthew, Zhang, Peijun, Alam, Mohammad T., Baxter, Laura, Bridgewater, Hannah E., Brown, Paul E., Cheng, Jeffrey K. J., Constantinidou, Chrystala, Frost, Lucy R., Ott, Sascha, Stark, Richard, Taylor-Joyce, Grace, Unnikrishnan, Meera, Cerda, Alberto C., Merrill, Tammy V., Wilson, Rebekah E., Ball, Jonathan, Chappell, Joseph G., McClure, Patrick C., Tsoleridis, Theocharis, Buck, David, de Cesare, Mariateresa, Green, Angie, MacIntyre-Cockett, George, Todd, John A., Trebes, Amy, Gunson, Rory N., Cormie, Claire, Dias, Joana, Forrest, Sally, Gill, Harmeet K., Higginson, Ellen E., Kermack, Leanne M., Maes, Mailis, Ruis, Chris, Sridhar, Sushmita, Young, Jamie, Howes, Rob, McFarlane, Duncan, Dougan, Gordon, Pybus, Oliver G., Maxwell, Patrick H., Weekes, Michael P., Illingworth, Chris, Harrison, Ewan M., Matheson, Nicholas J., Goodfellow, Ian G., The Cambridge Covid-19 testing Centre, University of Cambridge Asymptomatic COVID-19 Screening Programm, The COVID-19 Genomics UK (COG-UK) Consortium, Aggarwal, Dinesh [0000-0002-5938-8172], Warne, Ben [0000-0003-1326-0373], Hill, Verity [0000-0002-3509-8146], Pinckert, Malte [0000-0002-6072-5949], Leek, Danielle [0000-0001-5367-3354], Pybus, Oliver [0000-0001-6619-6112], Weekes, Michael [0000-0002-0030-2784], Apollo - University of Cambridge Repository, Jahun, Aminu S [0000-0002-4585-1701], Hamilton, William L [0000-0002-3330-353X], du Plessis, Louis [0000-0003-0352-6289], Blane, Beth [0000-0002-0996-9091], Wright, Elizabeth [0000-0002-8378-9072], Hall, Grant [0000-0003-3928-3979], Chaudhry, Yasmin [0000-0002-2386-3269], Pinckert, Malte L [0000-0002-6072-5949], Izuagbe, Rhys [0000-0001-8080-2510], Nsonwu, Olisaeloka [0000-0002-3024-700X], Hughes, Gareth J [0000-0002-3781-0117], Packer, Simon [0000-0002-9157-3650], Page, Andrew J [0000-0001-6919-6062], Metaxaki, Marina [0000-0002-4552-1622], Weale, Gillian [0000-0003-4728-5915], Brown, Christopher A [0000-0001-7773-0878], Peacock, Sharon J [0000-0002-1718-2782], Pybus, Oliver G [0000-0002-8797-2667], Weekes, Michael P [0000-0003-3196-5545], Harrison, Ewan M [0000-0003-2720-0507], Matheson, Nicholas J [0000-0002-3318-1851], Goodfellow, Ian G [0000-0002-9483-510X], Jahun, Aminu [0000-0002-4585-1701], Hosmillo, Myra [0000-0002-3514-7681], McFarlane, Duncan [0000-0002-1558-7823], Dougan, Gordon [0000-0003-0022-965X], Peacock, Sharon [0000-0002-1718-2782], Weekes, Michael [0000-0003-3196-5545], Illingworth, Christopher [0000-0002-0030-2784], Harrison, Ewan [0000-0003-2720-0507], Matheson, Nicholas [0000-0002-3318-1851], and Goodfellow, Ian [0000-0002-9483-510X]

Subjects
Universities, 631/326/325/2483, Science, education, University of Cambridge Asymptomatic COVID-19 Screening Programme Consortium, General Physics and Astronomy, Cambridge Covid-19 testing Centre, 45/23, Genome, Viral, General Biochemistry, Genetics and Molecular Biology, COVID-19 Genomics UK (COG-UK) Consortium, Risk Factors, The COVID-19 Genomics UK (COG-UK) Consortium, Humans, Students, Phylogeny, 631/326/596/4130, Multidisciplinary, SARS-CoV-2, article, COVID-19, virus diseases, C500, General Chemistry, Genomics, C700, 692/700/478/174, United Kingdom, The Cambridge Covid-19 testing Centre, RNA, Viral, 631/326/596/2562, Contact Tracing, 631/326/596/2563
Abstract

Understanding SARS-CoV-2 transmission in higher education settings is important to limit spread between students, and into at-risk populations. In this study, we sequenced 482 SARS-CoV-2 isolates from the University of Cambridge from 5 October to 6 December 2020. We perform a detailed phylogenetic comparison with 972 isolates from the surrounding community, complemented with epidemiological and contact tracing data, to determine transmission dynamics. We observe limited viral introductions into the university; the majority of student cases were linked to a single genetic cluster, likely following social gatherings at a venue outside the university. We identify considerable onward transmission associated with student accommodation and courses; this was effectively contained using local infection control measures and following a national lockdown. Transmission clusters were largely segregated within the university or the community. Our study highlights key determinants of SARS-CoV-2 transmission and effective interventions in a higher education setting that will inform public health policy during pandemics., Nature Communications, 13, ISSN:2041-1723

Published
2022

23. Cohort Profile: The National Institute for Health Research Health Informatics Collaborative: Hepatitis B Virus (NIHR HIC HBV) research dataset.

Author

Wang, Tingyan, Smith, David A, Campbell, Cori, Freeman, Oliver, Moysova, Zuzana, Noble, Theresa, Várnai, Kinga A, Harris, Steve, Salih, Hizni, Roadknight, Gail, Little, Stephanie, Glampson, Ben, Mercuri, Luca, Papadimitriou, Dimitri, Jones, Christopher R, Taylor, Vince, Chaudhry, Afzal, Phan, Hang, Borca, Florina, and Olza, Josune

Subjects
MEDICAL informatics, HEPATITIS B virus, HEPATITIS D, RESEARCH institutes, HEPATITIS associated antigen, PLANT viruses
Abstract

To avoid submitting duplication of records to the lead centre, each Trust is responsible for locally maintaining a link between the patient's local identifier and the anonymous study identifier used in the dataset.[14] The central data repository is based on a secure data access platform and only authorized personnel are permitted to access data. Key Features The National Institute for Health Research (NIHR) Health Informatics Collaborative (HIC) has established a cohort of individuals with chronic hepatitis B virus (HBV) infection in secondary care in the UK, providing a resource for translational research. We are unable to capture the retrospective data that might be stored in a different Trust for patients even when data from this Trust are added into the dataset, as it is not possible to map patients between Trusts within the dataset due to anonymization. The exclusion criteria were: (i) patients without records of demographics or (ii) patients without mandated laboratory data (Supplementary Tables S2, S3, available as Supplementary data at I IJE i online) in the EPR systems (Supplementary Figure S1, available as Supplementary data at I IJE i online). [Extracted from the article]

Published
2023
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24. Impact of the COVID-19 pandemic on routine surveillance for adults with chronic hepatitis B virus (HBV) infection in the UK

Author

Campbell, Cori, primary, Wang, Tingyan, additional, Smith, David A., additional, Freeman, Oliver, additional, Noble, Theresa, additional, Várnai, Kinga A, additional, Harris, Steve, additional, Salih, Hizni, additional, Roadknight, Gail, additional, Little, Stephanie, additional, Glampson, Ben, additional, Mercuri, Luca, additional, Papadimitriou, Dimitri, additional, Jones, Christopher R, additional, Taylor, Vince, additional, Chaudhry, Afzal, additional, Phan, Hang, additional, Borca, Florina, additional, Olza, Josune, additional, Warricker, Frazer, additional, Romão, Luis, additional, Ramlakhan, David, additional, English, Louise, additional, Klenerman, Paul, additional, Andersson, Monique I., additional, Collier, Jane, additional, Nastouli, Eleni, additional, Khakoo, Salim I., additional, Gelson, William, additional, Cooke, Graham S., additional, Woods, Kerrie, additional, Davies, Jim, additional, Barnes, Eleanor, additional, and Matthews, Philippa C., additional

Published
2022
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27. Impact of the COVID-19 pandemic on routine surveillance for adults with chronic hepatitis B virus (HBV) infection in the UK

Author

Campbell, Cori, primary, Wang, Tingyan, additional, Smith, David A, additional, Freeman, Oliver, additional, Noble, Theresa, additional, Várnai, Kinga A, additional, Harris, Steve, additional, Salih, Hizni, additional, Roadknight, Gail, additional, Little, Stephanie, additional, Glampson, Ben, additional, Mercuri, Luca, additional, Papadimitriou, Dimitri, additional, Jones, Christopher R, additional, Taylor, Vince, additional, Chaudhry, Afzal, additional, Phan, Hang, additional, Borca, Florina, additional, Olza, Josune, additional, Warricker, Frazer, additional, Romão, Luis, additional, Ramlakhan, David, additional, English, Louise, additional, Klenerman, Paul, additional, Andersson, Monique I., additional, Collier, Jane, additional, Nastouli, Eleni, additional, Khakoo, Salim I, additional, Gelson, William, additional, Cooke, Graham S, additional, Woods, Kerrie, additional, Davies, Jim, additional, Barnes, Eleanor, additional, and Matthews, Philippa C, additional

Published
2021
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28. Cohort Profile: National Institute for Health Research Health Informatics Collaborative: Hepatitis B Virus (NIHR HIC HBV) Research Dataset

Author

Wang, Tingyan, primary, Smith, David A, additional, Campbell, Cori, additional, Freeman, Oliver, additional, Moysova, Zuzana, additional, Noble, Theresa, additional, Várnai, Kinga A, additional, Harris, Steve, additional, Salih, Hizni, additional, Roadknight, Gail, additional, Little, Stephanie, additional, Glampson, Ben, additional, Mercuri, Luca, additional, Papadimitriou, Dimitri, additional, Jones, Christopher R, additional, Taylor, Vince, additional, Chaudhry, Afzal, additional, Phan, Hang, additional, Borca, Florina, additional, Olza, Josune, additional, Warricker, Frazer, additional, Romão, Luis, additional, Ramlakhan, David, additional, English, Louise, additional, Klenerman, Paul, additional, Andersson, Monique, additional, Collier, Jane, additional, Nastouli, Eleni, additional, Khakoo, Salim I, additional, Gelson, William, additional, Cooke, Graham S, additional, Woods, Kerrie, additional, Davies, Jim, additional, Barnes, Eleanor, additional, and Matthews, Philippa C, additional

Published
2021
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31. Single-dose BNT162b2 vaccine protects against asymptomatic SARS-CoV-2 infection

Author

Jones, Nick K, Rivett, Lucy, Seaman, Shaun, Samworth, Richard J, Warne, Ben, Workman, Chris, Ferris, Mark, Wright, Jo, Quinnell, Natalie, Shaw, Ashley, Cambridge COVID-19 Collaboration, Goodfellow, Ian G, Lehner, Paul J, Howes, Rob, Wright, Giles, Matheson, Nicholas J, Weekes, Michael P, Amory, Amy, Baker, Stephen, Bateman, Emma, Begum, Aklima, Begum, Moushima, Bradley, John, Brennan, Michael, Burn, Helen, Crofts, Caroline, Chaudhry, Afzal, Chaudhry, Yasmin, Cooper, Daniel J, Dawson, Sharon, Dougan, Gordon, Feather, Renny, Free, Louise, Friel, Katie, Gildea, Claire, Georgana, Iliana, Grimwade, Lizz, Gupta, Ravi, Hall, Susan, Hannan, Sophie, Hayes, James, Hosaja, Aleksandra, Hosmillo, Myra, Izuagbe, Rhys, Jahun, Aminu, James, Lidia, Jardin, Jill, Kingston, Nathalie, Lear, Sara, Lyons, Paul A, Maxwell, Patrick H, Mott, Sue, Mugavin, Sarah, Mwiya, Joyce, Peacock, Sharon, Nallattil, Ravi Prakash, Oloyede, Kazeem, Ouwehand, Willem H, Page, Elle, Perez, Marina, Raine, Tim, Routledge, Matthew, Saunders, Caroline, Smith, Kenneth GC, Sparkes, Dominic, Stafford, Maria, Summers, Charlotte, Tatsi, Despiona, Thaventhiran, James ED, Thomas Johnson, Sharon, Török, M Estée, Toshner, Mark, Turner, Lesley, Wall, Kate, Watson, Karis, Jones, Nick K [0000-0003-4475-7761], Rivett, Lucy [0000-0002-2781-9345], Goodfellow, Ian G [0000-0002-9483-510X], Lehner, Paul J [0000-0001-9383-1054], Matheson, Nicholas J [0000-0002-3318-1851], Weekes, Michael P [0000-0003-3196-5545], and Apollo - University of Cambridge Repository

Subjects
Microbiology and Infectious Disease, Epidemiology and Global Health, SARS-CoV-2, COVID-19, asymptomatic, BNT162b2, Pfizer-BioNTech, Research Advance, vaccination, Human
Abstract

The BNT162b2 mRNA COVID-19 vaccine (Pfizer-BioNTech) is being utilised internationally for mass COVID-19 vaccination. Evidence of single-dose protection against symptomatic disease has encouraged some countries to opt for delayed booster doses of BNT162b2, but the effect of this strategy on rates of asymptomatic SARS-CoV-2 infection remains unknown. We previously demonstrated frequent pauci- and asymptomatic SARS-CoV-2 infection amongst healthcare workers (HCWs) during the UK’s first wave of the COVID-19 pandemic, using a comprehensive PCR-based HCW screening programme (Rivett et al., 2020; Jones et al., 2020). Here, we evaluate the effect of first-dose BNT162b2 vaccination on test positivity rates and find a fourfold reduction in asymptomatic infection amongst HCWs ≥12 days post-vaccination. These data provide real-world evidence of short-term protection against asymptomatic SARS-CoV-2 infection following a single dose of BNT162b2 vaccine, suggesting that mass first-dose vaccination will reduce SARS-CoV-2 transmission, as well as the burden of COVID-19 disease.

Published
2021
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35. Monitoring indirect impact of COVID-19 pandemic on services for cardiovascular diseases in the UK

Author

Ball, Simon, Banerjee, Amitava, Berry, Colin, Boyle, Jonathan R, Bray, Benjamin, Bradlow, William, Chaudhry, Afzal, Crawley, Rikki, Danesh, John, Denniston, Alastair, Falter, Florian, Figueroa, Jonine D, Hall, Christopher, Hemingway, Harry, Jefferson, Emily, Johnson, Tom, King, Graham, Lee, Kuan Ken, McKean, Paul, Mason, Suzanne, Mills, Nicholas L, Pearson, Ewen, Pirmohamed, Munir, Poon, Michael TC, Priedon, Rouven, Shah, Anoop, Sofat, Reecha, Sterne, Jonathan AC, Strachan, Fiona E, Sudlow, Cathie LM, Szarka, Zsolt, Whiteley, William, Wyatt, Michael, CVD-COVID-UK Consortium, Banerjee, Amitava [0000-0001-8741-3411], Berry, Colin [0000-0002-4547-8636], Hemingway, Harry [0000-0003-2279-0624], Lee, Kuan Ken [0000-0003-3404-4098], Mills, Nicholas L [0000-0003-0533-7991], Poon, Michael TC [0000-0002-0053-2184], and Apollo - University of Cambridge Repository

Subjects
health care delivery, Health Services Needs and Demand, Time Factors, Delivery of Health Care, Integrated, COVID-19, heart disease, global health care delivery, United Kingdom, aortic and arterial disease, Cross-Sectional Studies, Patient Admission, Cardiovascular Diseases, Humans, epidemiology, Cardiology Service, Hospital, Emergency Service, Hospital, Needs Assessment, Retrospective Studies
Abstract

OBJECTIVE: To monitor hospital activity for presentation, diagnosis and treatment of cardiovascular diseases during the COVID-19) pandemic to inform on indirect effects. METHODS: Retrospective serial cross-sectional study in nine UK hospitals using hospital activity data from 28 October 2019 (pre-COVID-19) to 10 May 2020 (pre-easing of lockdown) and for the same weeks during 2018-2019. We analysed aggregate data for selected cardiovascular diseases before and during the epidemic. We produced an online visualisation tool to enable near real-time monitoring of trends. RESULTS: Across nine hospitals, total admissions and emergency department (ED) attendances decreased after lockdown (23 March 2020) by 57.9% (57.1%-58.6%) and 52.9% (52.2%-53.5%), respectively, compared with the previous year. Activity for cardiac, cerebrovascular and other vascular conditions started to decline 1-2 weeks before lockdown and fell by 31%-88% after lockdown, with the greatest reductions observed for coronary artery bypass grafts, carotid endarterectomy, aortic aneurysm repair and peripheral arterial disease procedures. Compared with before the first UK COVID-19 (31 January 2020), activity declined across diseases and specialties between the first case and lockdown (total ED attendances relative reduction (RR) 0.94, 0.93-0.95; total hospital admissions RR 0.96, 0.95-0.97) and after lockdown (attendances RR 0.63, 0.62-0.64; admissions RR 0.59, 0.57-0.60). There was limited recovery towards usual levels of some activities from mid-April 2020. CONCLUSIONS: Substantial reductions in total and cardiovascular activities are likely to contribute to a major burden of indirect effects of the pandemic, suggesting they should be monitored and mitigated urgently.

Published
2020
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36. A [CD8.sup.+] T cell transcription signature predicts prognosis in autoimmune disease

Author

McKinney, Eoin F., Lyons, Paul A., Carr, Edward J., Hollis, Jane L., Jayne, David R.W., Willcocks, Lisa C., Koukoulaki, Maria, Brazma, Alvis, Jovanovic, Vojislav, Kemeny, D. Michael, Pollard, Andrew J., MacAry, Paul A., Chaudhry, Afzal N., and Smith, Kenneth G.C.

Subjects
T cells -- Health aspects, Transcription factors -- Health aspects, Autoimmune diseases -- Prognosis, Biological sciences, Health
Abstract

Autoimmune diseases are common and debilitating, but their severe manifestations could be reduced if biomarkers were available to allow individual tailoring of potentially toxic immunosuppressive therapy. Gene expression-based biomarkers facilitating such tailoring of chemotherapy in cancer, but not autoimmunity, have been identified and translated into clinical practice (1,2). We show that transcriptional profiling of purified [CD8.sup.+] T cells, which avoids the confounding influences of unseparated cells (3,4), identifies two distinct subject subgroups predicting long-term prognosis in two autoimmune diseases, antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), a chronic, severe disease characterized by inflammation of medium-sized and small blood vessels (5), and systemic lupus erythematosus (SLE), characterized by autoantibodies, immune complex deposition and diverse clinical manifestations ranging from glomerulonephritis to neurological dysfunction (6). We show that the subset of genes defining the poor prognostic group is enriched for genes involved in the interleukin-7 receptor (IL-7R) pathway and T cell receptor (TCR) signaling and those expressed by memory T cells. Furthermore, the poor prognostic group is associated with an expanded [CD8.sup.+] T cell memory population. These subgroups, which are also found in the normal population and can be identified by measuring expression of only three genes, raise the prospect of individualized therapy and suggest new potential therapeutic targets in autoimmunity., The three clinical syndromes that make up AAV (Wegener's granulomatosis, microscopic polyangiitis and Churg-Strauss syndrome) have diverse and overlapping clinical features, including acute glomerulonephritis and granulomatous inflammation of the respiratory [...]

Published
2010
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37. Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission

Author

Rivett, Lucy, Sridhar, Sushmita, Sparkes, Dominic, Routledge, Matthew, Jones, Nick K, Forrest, Sally, Young, Jamie, Pereira-Dias, Joana, Hamilton, William L, Ferris, Mark, Torok, M Estee, Meredith, Luke, Collaboration, The CITIID-NIHR COVID-19 BioResource, Curran, Martin D, Fuller, Stewart, Chaudhry, Afzal, Shaw, Ashley, Samworth, Richard J, Bradley, John R, Dougan, Gordon, Smith, Kenneth GC, Lehner, Paul J, Matheson, Nicholas J, Wright, Giles, Goodfellow, Ian G, Baker, Stephen, Weekes, Michael P, Gupta, Ravi, Lyons, Paul A, Toshner, Mark, Warne, Ben, Bartholdson Scott, Josefin, Cormie, Claire, Gill, Harmeet, Kean, Iain, Maes, Mailis, Reynolds, Nicola, Wantoch, Michelle, Caddy, Sarah, Caller, Laura, Feltwell, Theresa, Hall, Grant, Hosmillo, Myra, Houldcroft, Charlotte, Jahun, Aminu, Khokhar, Fahad, Yakovleva, Anna, Butcher, Helen, Caputo, Daniela, Clapham-Riley, Debra, Dolling, Helen, Furlong, Anita, Graves, Barbara, Gresley, Emma Le, Kingston, Nathalie, Papadia, Sofia, Stark, Hannah, Stirrups, Kathleen E, Webster, Jennifer, Calder, Joanna, Harris, Julie, Hewitt, Sarah, Kennet, Jane, Meadows, Anne, Rastall, Rebecca, Brien, Criona O, Price, Jo, Publico, Cherry, Rowlands, Jane, Ruffolo, Valentina, Tordesillas, Hugo, Brookes, Karen, Canna, Laura, Cruz, Isabel, Dempsey, Katie, Elmer, Anne, Escoffery, Naidine, Jones, Heather, Ribeiro, Carla, Saunders, Caroline, Wright, Angela, Nyagumbo, Rutendo, Roberts, Anne, Bucke, Ashlea, Hargreaves, Simone, Johnson, Danielle, Narcorda, Aileen, Read, Debbie, Sparke, Christian, Warboys, Lucy, Lagadu, Kirsty, Mactavous, Lenette, Gould, Tim, Raine, Tim, Mather, Claire, Ramenatte, Nicola, Vallier, Anne-Laure, Kasanicki, Mary, Eames, Penelope-Jane, McNicholas, Chris, Thake, Lisa, Bartholomew, Neil, Brown, Nick, Parmar, Surendra, Zhang, Hongyi, Bowring, Ailsa, Martell, Geraldine, Quinnell, Natalie, Wright, Jo, Murphy, Helen, Dunmore, Benjamin J, Legchenko, Ekaterina, Gräf, Stefan, Huang, Christopher, Hodgson, Josh, Hunter, Kelvin, Martin, Jennifer, Mescia, Federica, O'Donnell, Ciara, Pointon, Linda, Shih, Joy, Sutcliffe, Rachel, Tilly, Tobias, Tong, Zhen, Treacy, Carmen, Wood, Jennifer, Bergamaschi, Laura, Betancourt, Ariana, Bowyer, Georgie, De Sa, Aloka, Epping, Maddie, Hinch, Andrew, Huhn, Oisin, Jarvis, Isobel, Lewis, Daniel, Marsden, Joe, McCallum, Simon, Nice, Francescsa, Rivett, Lucy [0000-0002-2781-9345], Lehner, Paul J [0000-0001-9383-1054], Matheson, Nicholas J [0000-0002-3318-1851], Goodfellow, Ian G [0000-0002-9483-510X], Weekes, Michael P [0000-0003-3196-5545], and Apollo - University of Cambridge Repository

Subjects
Epidemiology and Global Health, SARS-CoV-2, infectious disease, education, occupational health, virus diseases, COVID-19, Human Biology and Medicine, Research Article, virology, emerging pathogens, Human, Virus
Abstract

Funder: Addenbrooke's Charitable Trust, Cambridge University Hospitals; FundRef: http://dx.doi.org/10.13039/501100002927, Significant differences exist in the availability of healthcare worker (HCW) SARS-CoV-2 testing between countries, and existing programmes focus on screening symptomatic rather than asymptomatic staff. Over a 3 week period (April 2020), 1032 asymptomatic HCWs were screened for SARS-CoV-2 in a large UK teaching hospital. Symptomatic staff and symptomatic household contacts were additionally tested. Real-time RT-PCR was used to detect viral RNA from a throat+nose self-swab. 3% of HCWs in the asymptomatic screening group tested positive for SARS-CoV-2. 17/30 (57%) were truly asymptomatic/pauci-symptomatic. 12/30 (40%) had experienced symptoms compatible with coronavirus disease 2019 (COVID-19)>7 days prior to testing, most self-isolating, returning well. Clusters of HCW infection were discovered on two independent wards. Viral genome sequencing showed that the majority of HCWs had the dominant lineage B∙1. Our data demonstrates the utility of comprehensive screening of HCWs with minimal or no symptoms. This approach will be critical for protecting patients and hospital staff.

Published
2020
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38. Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19

Author

Jones, Nick K, Rivett, Lucy, Sparkes, Dominic, Forrest, Sally, Sridhar, Sushmita, Young, Jamie, Pereira-Dias, Joana, Cormie, Claire, Gill, Harmeet, Reynolds, Nicola, Wantoch, Michelle, Routledge, Matthew, Warne, Ben, Levy, Jack, Córdova Jiménez, William David, Samad, Fathima Nisha Begum, McNicholas, Chris, Ferris, Mark, Gray, Jane, Gill, Michael, Collaboration, The CITIID-NIHR COVID-19 BioResource, Curran, Martin D, Fuller, Stewart, Chaudhry, Afzal, Shaw, Ashley, Bradley, John R, Hannon, Gregory J, Goodfellow, Ian G, Dougan, Gordon, Smith, Kenneth GC, Wright, Giles, Baker, Stephen, Weekes, Michael P, Bradley, John, Goodfellow, Ian, Gupta, Ravi, Lehner, Paul J, Lyons, Paul A, Matheson, Nicholas J, Torok, M Estee, Toshner, Mark, Jones, Nick K [0000-0003-4475-7761], Sridhar, Sushmita [0000-0001-7453-7482], Hannon, Gregory J [0000-0003-4021-3898], Goodfellow, Ian G [0000-0002-9483-510X], Lehner, Paul J [0000-0001-9383-1054], Matheson, Nicholas J [0000-0002-3318-1851], Weekes, Michael P [0000-0003-3196-5545], and Apollo - University of Cambridge Repository

Subjects
Epidemiology and Global Health, SARS-CoV-2, infectious disease, occupational health, virus diseases, COVID-19, Research Advance, Human Biology and Medicine, virology, emerging pathogens, Human
Abstract

Funder: Addenbrooke's Charitable Trust, Cambridge University Hospitals; FundRef: http://dx.doi.org/10.13039/501100002927, Funder: National Institute for Health Research; FundRef: http://dx.doi.org/10.13039/501100000272, Previously, we showed that 3% (31/1032)of asymptomatic healthcare workers (HCWs) from a large teaching hospital in Cambridge, UK, tested positive for SARS-CoV-2 in April 2020. About 15% (26/169) HCWs with symptoms of coronavirus disease 2019 (COVID-19) also tested positive for SARS-CoV-2 (Rivett et al., 2020). Here, we show that the proportion of both asymptomatic and symptomatic HCWs testing positive for SARS-CoV-2 rapidly declined to near-zero between 25th April and 24th May 2020, corresponding to a decline in patient admissions with COVID-19 during the ongoing UK ‘lockdown’. These data demonstrate how infection prevention and control measures including staff testing may help prevent hospitals from becoming independent ‘hubs’ of SARS-CoV-2 transmission, and illustrate how, with appropriate precautions, organizations in other sectors may be able to resume on-site work safely.

Published
2020

39. WED-137 - Distinct virologic trajectories in chronic hepatitis B patients identify heterogeneity in response to nucleotide analogue therapy

Author

Wang, Tingyan, Campbell, Cori, Roadknight, Gail, Little, Stephanie, Stockdale, Alexander, Todd, Stacy, McIntyre, Karl, Frankland, Andrew, Jaworski, Jakub, Chaudhry, Afzal, Glampson, Ben, Mercuri, Luca, Papadimitriou, Dimitri, Jones, Christopher R., Varnai, Kinga, Noble, Theresa, Salih, Hizni, Davis, Cai, Heinson, Ashley, George, Michael, Borca, Florina, Olza, Josune, English, Louise, Romão, Luis, Ramlakhan, David, Nastouli, Eleni, Khakoo, Salim, Gelson, Will, Cooke, Graham, Woods, Kerrie, Davies, Jim, Matthews, Philippa, and Barnes, Eleanor

Published
2023
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40. A Comprehensive Study of Clinical, Biochemical, Radiological, Vascular, Cardiac, and Sleep Parameters in an Unselected Cohort of Patients With Acromegaly Undergoing Presurgical Somatostatin Receptor Ligand Therapy

Author

Annamalai, Anand K., Webb, Alison, Kandasamy, Narayanan, Elkhawad, Maysoon, Moir, Samantha, Khan, Fakhar, Maki-Petaja, Kaisa, Gayton, Emma L., Strey, Christopher H., OʼToole, Samuel, Ariyaratnam, Shaumya, Halsall, David J., Chaudhry, Afzal N., Berman, Laurence, Scoffings, Daniel J., Antoun, Nagui M., Dutka, David P., Wilkinson, Ian B., Shneerson, John M., Pickard, John D., Simpson, Helen L., and Gurnell, Mark

Published
2013

50. Genetically Distinct Subsets within ANCA-Associated Vasculitis

Author

Lyons, Paul A., Rayner, Tim F., Trivedi, Sapna, Holle, Julia U., Watts, Richard A., Jayne, David R.W., Baslund, Bo, Brenchley, Paul, Bruchfeld, Annette, Chaudhry, Afzal N., Cohen Tervaert, Jan Willem, Deloukas, Panos, Feighery, Conleth, Gross, Wolfgang L., Guillevin, Loic, Gunnarsson, Iva, Harper, Lorraine, Hrušková, Zdenka, Little, Mark A., Martorana, Davide, Neumann, Thomas, Ohlsson, Sophie, Padmanabhan, Sandosh, Pusey, Charles D., Salama, Alan D., Sanders, Jan-Stephan F., Savage, Caroline O., Segelmark, Mårten, Stegeman, Coen A., Tesař, Vladimir, Vaglio, Augusto, Wieczorek, Stefan, Wilde, Benjamin, Zwerina, Jochen, Rees, Andrew J., Clayton, David G., and Smith, Kenneth G.C.

Published
2012

Catalog

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