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146 results on '"Clauvel, Jean-Pierre"'

1. Pulmonary Arterial Hypertension Associated With Systemic Lupus Erythematosus: Results From the French Pulmonary Hypertension Registry

Author

Hachulla, Eric, Jais, Xavier, Cinquetti, Gaël, Clerson, Pierre, Rottat, Laurence, Launay, David, Cottin, Vincent, Habib, Gilbert, Prevot, Grégoire, Chabanne, Céline, Foïs, Eléna, Amoura, Zahir, Mouthon, Luc, Le Guern, Véronique, Montani, David, Simonneau, Gérald, Humbert, Marc, Sobanski, Vincent, Sitbon, Olivier, Balquet, Marie-Hélène, Ziza, Jean-Marc, Clauvel, Jean-Pierre, Brouet, Jean-Claude, Pison, Christophe, Chabot, Jean-François, Velly, Jean-François, Dos Santos, Pierre-Dominique, Meurice, Jean-Claude, Fauchais, Anne-Laure, Guillevin, Loïc, Cadranel, Jacques, Traclet, Julie, Mornex, Jean-François, Mabo, Philippe, and Didier, Alain

Published
2018
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5. A Comparison of Cell Activation, Exhaustion, and Expression of HIV Coreceptors and Restriction Factors in HIV-1- and HIV-2-Infected Nonprogressors

Author

Diallo, Mariama Sadjo, Samri, Assia, Charpentier, Charlotte, Bertine, Mélanie, Cheynier, Rémi, Thiébaut, Rodolphe, Matheron, Sophie, Collin, Fidéline, Braibant, Martine, Candotti, Daniel, Appay, Victor, Brun-Vézinet, Françoise, Chaghil, Nathalie, Descamps, Diane, Hosmalin, Anne, Pancino, Gianfranco, Manel, Nicolas, Marchand, Lucie, Pedroza-Martins, Livia, Sáez-Cirión, Asier, Agut, Henri, Clauvel, Jean-Pierre, Costagliola, Dominique, Debré, Patrice, Theodorou, Ioannis, Sicard, Didier, Viard, Jean-Paul, Barin, Francis, Vieillard, Vincent, Autran, Brigitte, Centre d'Immunologie et de Maladies Infectieuses (CIMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU), Laboratoire de Virologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC), Equipe de Biostatistique, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR99-ISPED, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service des maladies infectieuses et tropicales, Université Paris Diderot - Paris 7 (UPD7)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Epidémiologie, santé publique et développement, Virus, pseudo-virus: Morphogénèse et Antigénicité, Université de Tours (UT)-EA3856, CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université de Tours-EA3856

Subjects
0301 basic medicine, CD4-Positive T-Lymphocytes, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Ubiquitin-Protein Ligases, Immunology, Human immunodeficiency virus (HIV), HIV Infections, Biology, medicine.disease_cause, West africa, HIV Long-Term Survivors, Antiviral Restriction Factors, Tripartite Motif Proteins, 03 medical and health sciences, 0302 clinical medicine, Virology, medicine, Humans, 030212 general & internal medicine, ComputingMilieux_MISCELLANEOUS, virus diseases, 3. Good health, 030104 developmental biology, Infectious Diseases, HIV-2, HIV-1, [SDV.IMM]Life Sciences [q-bio]/Immunology, Cell activation
Abstract

Human immunodeficiency viruses induce rare attenuated diseases due either to HIV-1 in the exceptional long-term nonprogressors (LTNPs) or to HIV-2 in West Africa. To better understand characteristics of these two disease types we performed a multiplex comparative analysis of cell activation, exhaustion, and expression of coreceptors and restriction factors in CD4 T cells susceptible to harbor those viruses. We analyzed by flow cytometry the expression of HLA-DR, PD1, CCR5, CXCR6, SAMHD1, Blimp-1, and TRIM5α on CD4 T cell subsets from 10 HIV-1

Published
2020

8. Transient angiolymphoid hyperplasia and Kaposi's sarcoma after primary infection with human herpesvirus 8 in a patient with human immunodeficiency virus infection

Author

Oksenhendler, Eric, Cazals-Hatem, Dominique, Schulz, Thomas F., Barateau, Veronique, Grollet, Laurence, Sheldon, Julie, Clauvel, Jean-Pierre, Sigaux, Francois, and Agbalika, Felix

Subjects
Human herpesvirus 8 -- Health aspects, Virus diseases -- Causes of, HIV patients -- Diseases
Abstract

The case of a 43-year-old HIV patient illustrates that human herpesvirus 8 can cause an acute illness that may resolve completely without causing Kaposi's sarcoma. This virus has consistently been isolated from Kaposi's sarcoma tumor samples in HIV patients. This patient became ill with fever, joint pain and enlarged lymph nodes. Within 8 weeks, the lymph nodes returned to normal and he had no more symptoms. Analysis of blood samples taken before and after the illness revealed that he had seroconverted to HHV-8 during that time and the virus was detected in lymph node biopsy samples.

Published
1998

18. Treatment of the acquired immune deficiency syndrome-related Kaposi's sarcoma with bleomycin as a single agent

Author

Lassoued, Kaiss, Clauvel, Jean-Pierre, Katlama, Christine, Janier, Michel, Picard, Catherine, and Matheron, Sophie

Subjects
Bleomycin -- Adverse and side effects, Bleomycin -- Evaluation, Kaposi's sarcoma, AIDS (Disease) -- Complications, Health
Abstract

Kaposi's sarcoma (KS) is a form of malignant tumor characterized by multiple areas of cell overgrowth, initially affecting the skin but later developing in other body sites. The lesions may become sarcomatous, involving connective tissue such as bone and muscle. This particular malignancy is seen in 10 to 20 percent of AIDS patients, who more often die of infections than KS. The effectiveness and toxicity of the anticancer agent bleomycin in treating non-life-threatening Kaposi's sarcoma associated with AIDS were assessed in 60 afflicted patients. These patients had widespread and progressive Kaposi's sarcoma with symptoms affecting the entire body and a CD4 count of less than 400 per cubic millimeter, an index of poor immune function. Bleomycin was given into muscle in 30 patients and by slow continuous intravenous infusion in the remaining 30 patients. The average duration of treatment was five months. Bleomycin treatment resulted in some elimination of the tumors in 29 patients; it stabilized or prevented further progression of the cancer in 18 additional patients; and it had no effect in 21.6 percent of patients. Bleomycin was discontinued in two patients because of adverse side effects. These findings suggest that bleomycin may serve as a alternative treatment for AIDS-related Kaposi's sarcoma. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1990

21. Autoimmune cytopenias associated with autoantibodies to nuclear envelope polypeptides

Author

Coppo, Paul, Clauvel, Jean-Pierre, Bengoufa, Djaouida, Fuentes, Vincent, Gouilleux-Gruart, Valérie, Courvalin, Jean-Claude, Lassoued, Kaiss, Gouilleux-Gruart, Val�rie, Université Pierre et Marie Curie - Paris 6 (UPMC), Laboratoire Jean Dausset, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Développement normal et pathologique des lymphocytes et signalisation, Université de Picardie Jules Verne (UPJV)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Jacques Monod (IJM (UMR_7592)), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Université de Picardie Jules Verne (UPJV)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Adult, Male, Vasculitis, Hemolytic anemia, Pathology, medicine.medical_specialty, Neutropenia, Adolescent, Anti-nuclear antibody, Nuclear Envelope, Pancytopenia, [SDV]Life Sciences [q-bio], Immunoblotting, medicine.disease_cause, Autoimmune Diseases, Liver disorder, Autoimmunity, 03 medical and health sciences, 0302 clinical medicine, Coombs test, Autoimmune Process, hemic and lymphatic diseases, medicine, Humans, Aged, Autoantibodies, Retrospective Studies, 030304 developmental biology, 0303 health sciences, Systemic lupus erythematosus, medicine.diagnostic_test, business.industry, Liver Diseases, Autoantibody, Nuclear Proteins, Hematology, Middle Aged, medicine.disease, 3. Good health, Coombs Test, Treatment Outcome, Purpura, Thrombocytopenic, 030220 oncology & carcinogenesis, Immunology, Female, Anemia, Hemolytic, Autoimmune, Peptides, business, Follow-Up Studies
Abstract

International audience; A subset of anti-nuclear autoantibodies (ANA) are directed against nuclear envelope (NE) polypeptides and display by indirect immunofluorescence (IIF) a ring-like fluorescent pattern. We report herein 19 patients with autoimmune cytopenias associated with antibodies (Abs) to NE polypeptides. Anti-NE specificity was determined by immunoblot, using NE preparations and purified lamina fractions. Eleven sera reacted with lamin B(1), and two reacted with both lamin B(1) and an unidentified 150-kDa protein (p150). One serum reacted with only p150. Four sera reacted with lamins A and C, and one reacted with and an unidentified 52-kDa NE polypeptide (p52). Autoimmune cytopenias included hemolytic anemia (7 cases), thrombocytopenia (13 cases), and neutropenia (6 cases). Five patients had 2 (3 cases) or 3 (2 cases) different cytopenias. Antiphospholipid antibodies (APLA) were detected in 14 patients, 2 of whom experienced thromboembolic events. A liver disorder was present in 7 patients. Systemic lupus erythematosus and lupus-like syndrome were diagnosed in 11 and 2 patients, respectively. Cytopenias responded to steroids alone (13 patients), or together with intravenous immunoglobulins (2 patients), or cyclophosphamide (2 patients). Two patients did not require treatment. Our results suggest that anti-NE Abs need to be sought for in patients with peripheral cytopenias, particularly when they are associated with APLA and/or liver disorders. Their detection strongly suggests an autoimmune process. Such cytopenias are often manifestations of a lupus or lupus-like disease and are responsive to steroids.

Published
2004

22. Chlorambucil-associated pneumonitis

Author

Crestani, Bruno, Jaccard, Arnaud, Isreal-Biet, Dominique, Couderc, Louis-Jean, Frija, Jacques, and Clauvel, Jean-Pierre

Subjects
Bacterial pneumonia -- Causes of -- Complications and side effects, Chlorambucil -- Complications and side effects, Pneumonia -- Causes of -- Complications and side effects, Health, Complications and side effects, Causes of
Abstract

A patient developed an interstitial pneumonitis while receiving chlorambucil for a chronic lymphocytic leukemia (cumulative dose, 8,340 mg). Withdrawal of drug treatment was followed by rapid improvement in the clinical [...]

Published
1994

24. CD8 lymphocytosis and pseudotumoral splenomegaly in HIV infection

Author

Oksenhendler, Eric, Autran, Brigitte, Gorochov, Guy, D'Agay, Marie Francoise, Seligman, Maxime, and Clauvel, Jean-Pierre

Subjects
Splenomegaly -- Causes of, HIV infection -- Genetic aspects, CD8 lymphocytes -- Physiological aspects
Published
1992

38. Lymphomas in Patients With Sjögren's Syndrome Are Marginal Zone B-Cell Neoplasms, Arise in Diverse Extranodal and Nodal Sites, and Are Not Associated With Viruses

Author

Royer, Bruno, primary, Cazals-Hatem, Dominique, additional, Sibilia, Jean, additional, Agbalika, Felix, additional, Cayuela, Jean-Michel, additional, Soussi, Thierry, additional, Maloisel, Frédéric, additional, Clauvel, Jean-Pierre, additional, Brouet, Jean-Claude, additional, and Mariette, Xavier, additional

Published
1997
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45. Non-inflammatory herpes simplex hepatitis in an adult with chronic neutropenia.

Author

Bernuau, Jacques, Rueff, Bernard, Clauvel, Jean-Pierre, Degott, Claude, Perol, Yvonne, and Benhamou, Jean-Pierre

Abstract

ABSTRACT- We report the case of a young woman with chronic neutropenia, in whom hepatitis, extensive herpetic eruption and herpes simplex viremia developed after genital herpetic ulceration. Although severe liver necrosis was present, the patient's death did not result from hepatic failure. No inflammatory cell infiltration was found circumscribing the multiple necrotic foci in the liver. This absence of inflammatory cell infiltration reflects the host's inability to normally restrain herpes simplex virus dissemination and, in this patient, might be the consequence of chronic neutropenia. [ABSTRACT FROM AUTHOR]

Published
1981
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47. Antinuclear Autoantibodies Specific for Lamins.

Author

Lassaoued, Kaiss, Guilly, Marie-Noelle, Danon, Francoise, Andre, Chantal, Dhumeaux, Daniel, Clauvel, Jean-Pierre, Brouet, Jean-Claude, Seligmann, Maxime, and Courvalin, Jean-Claude

Subjects
ANTINUCLEAR factors, AUTOIMMUNE diseases, AUTOANTIBODIES, PATIENTS
Abstract

Presents information on a study which examined the antinuclear autoantibodies of several patients with chronic autoimmune disorder for lamins. Methodology of the study; Results and discussion.

Published
1988
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49. Splenectomy Is Safe and Effective in Human Immunodeficiency Virus-Related Immune Thrombocytopenia

Author

Oksenhendler, Eric, Bierling, Philippe, Chevret, Sylvie, Delfraissy, Jean-François, Laurian, Yves, Clauvel, Jean-Pierre, and Seligmann, Maxime

Abstract

Sixty-eight patients, followed in a prospective cohort study of 185 human immunodeficiency virus (HIV)-infected patients with severe immune thrombocytopenia (platelets < 50 × 109/L), underwent splenectomy, 2 to 41 months (median: 10 months) after immune thrombocytopenic purpura (ITP) was diagnosed. The mean platelet count increased from 18×109/L to 223 × 109/L with a persistent increase in 56 (82%). It also led to a significant increase of the mean CD4 cell count from 475 × 106/L to 725 × 106/L within a mean delay of 10 months. In the whole cohort, with a mean follow-up of 63 months (range, 6 to 126), the 5-year estimated rate for progression to acquired immunodeficiency syndrome (AIDS) was 23% (95% confidence interval [Cl], 15% to 31%) and the AIDS-free survival was 69% (95% Cl, 61 % to 77%). To investigate the potential impact of splenectomy, a Cox’s multiple regression model was used; as splenectomy was not randomly assigned, it was incorporated as a time-dependent covariate. After adjustment on the CD4 cell count, no statistically significant differences were observed between the splenectomized and the nonsplenectomized patients: AIDS progression rate (P= 0,23), survival (P= 0,64) and AIDS-free survival (P= 0,72) were not influenced by splenectomy. Splenectomy is both effective and safe in the treatment of severe, refractory ITP associated with HIV infection.

Published
1993
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50. Waldenström's Macroglobulinemia and Peripheral Neuropathy: A Clinical and Immunologic Study of 25 Patients

Author

Dellagi, Koussay, Dupouey, Pierre, Brouet, Jean Claude, Billecocq, Agnès, Gomez, Danielle, Clauvel, Jean Pierre, and Seligmann, Maxime

Abstract

We investigated, by indirect immunofluorescence, the binding of monoclonal IgM to human peripheral nerve in 25 patients with Waldenström's macroglobulinemia and peripheral neuropathy. In 10 cases (40%), an antibody activity against the myelin sheaths was demonstrated. The reactivity was mediated by the F(ab′)2fragments of the IgM. Prior delipidation of nervous tissue was needed to allow full expression of the target antigen(s). In nine cases, the IgM reacted with both peripheral and central myelin of primates, but not mouse or rabbit nervous tissue. In one case, the IgM reacted only with human peripheral nerve. The patients, whose IgM had an antibody activity to myelin antigen(s), had some distinct hematologic and neurologic features. The peripheral neuropathy always antedated the hematologic symptoms by several years. The serum level of the monoclonal IgM was low in all cases, and overt lymphoid malignancy was frequently absent. In other patients with neuropathy, the monoclonal IgM, which lacked antimyelin antibody activity, displayed either cross-idiotypic antigenic determinants or anti-intermediate filament antibody activity. These results taken together emphasize the heterogeneity of antibody activity of the monoclonal IgM from patients with Waldenström's macroglobulinemia and peripheral neuropathy.

Published
1983
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