1,122 results on '"Coelhos"'
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2. Clinical and histopathological study of a hollow and posteriorly multiperforated polymethylmethacrylate implant in eviscerated rabbit eyes.
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Lopes e Silva, Marlos R., Chahud, Fernando, and Cruz, Antonio Augusto V.
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MULTINUCLEATED giant cells ,POLYMETHYLMETHACRYLATE ,STAINS & staining (Microscopy) ,RABBITS ,HISTOPATHOLOGY ,INFLAMMATION ,EDENTULOUS mouth ,HEMATOXYLIN & eosin staining - Abstract
Copyright of Arquivos Brasileiros de Oftalmologia is the property of Arquivos Brasileiros de Oftalmologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2023
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3. O coelho é a saúva: a proposta brasileira e o uso do vírus do mixoma (MYXV) contra a praga de coelhos na Austrália, 1896-1952
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Gabriel Lopes and Jorge Tibilletti de Lara
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mixomatose infecciosa ,Austrália ,coelhos ,controle biológico ,MYXV ,History of medicine. Medical expeditions ,R131-687 - Abstract
Resumo O artigo analisa a singularidade dos processos históricos, científicos e políticos que vão da descoberta da doença que passou a ser conhecida como mixomatose infecciosa, causada pelo vírus do mixoma (MYXV), à sua aplicação no controle de uma praga de coelhos na Austrália. A narrativa segue especialmente as pesquisas de Henrique de Beaurepaire Aragão, pesquisador do Instituto Oswaldo Cruz, e posteriormente os esforços da cientista Jean Macnamara para promover pesquisas e implementar o MYXV na Austrália. Foram consultadas notas de pesquisa de cientistas, documentos oficiais que registraram o desenvolvimento dos experimentos, bem como periódicos. Nesse processo, foi considerado o desenvolvimento histórico do campo de estudos da virologia e controle biológico.
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- 2022
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4. Alendronato de sódio tópico associado ao osso bovino liofilizado no reparo ósseo
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Laisa Kindely Ramos de OLIVEIRA, Mariana da Silva BONATTO, Stela Maris Wanderley ROCHA, Fabiano Gonzaga RODRIGUES, Roberta Moreira FRANÇA, Daniela Nascimento SILVA, and Francisco de Assis LIMEIRA JÚNIOR
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Bifosfonatos ,alendronato ,calvária ,regeneração óssea ,coelhos ,tecido ósseo ,substitutos ósseos ,Medicine ,Dentistry ,RK1-715 - Abstract
Resumo Introdução O osso bovino inorgânico é o enxerto mais utilizado na Odontologia, tendo como desvantagem longo tempo de integração ao leito receptor. Os bifosfonatos têm sido utilizados para modular a quantidade e a qualidade do osso regenerado e diminuir o tempo de integração do enxerto. Objetivo Avaliar o efeito do bifosfonato alendronato de sódio (ALN) 0,5%, associado ou não ao osso bovino inorgânico, na reparação de defeitos ósseos. Material e método Dois defeitos ósseos foram confeccionados na calvária de 12 coelhos, sendo a cavidade esquerda/experimental preenchida com: GI = osso bovino inorgânico (Bio-Oss®); GII = Bio-Oss® + ALN 0,5%; GIII = ALN 0,5%; e a cavidade direita por coágulo sanguíneo (controle). Os animais foram mortos aos 60 dias pós-operatórios. Por meio de análise histomorfométrica calculou-se o percentual de osso neoformado e remanescente do biomaterial em relação à área total do defeito. Resultado Osso neoformado: GI = 38,16 ± 15,44%; GII = 55,77 ± 16,75%; GII I = 60,28 ± 11,45%. Controle = 45,11 ± 11,09%. Remanescente do enxerto: GI = 7,02 ± 5,36% e GII = 16,59 ± 9,56%. Não houve diferença quanto ao percentual de osso neoformado entre os grupos (ANOVA p = 0,15512; teste de Tukey F = 2,089). O percentual de remanescente do enxerto também foi estatisticamente semelhante entre os grupos GI e GII (teste de Tukey F = 5,019). Conclusão O uso tópico da solução de ALN 0,5% isoladamente ou associado ao osso bovino liofilizado não alterou o percentual de neoformação óssea nem a degradação dos grânulos do enxerto.
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- 2022
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5. Hiperplasia endometrial cística em uma coelha-doméstica (Oryctolagus cuniculus domesticus).
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Zafalon da Silva, Bruna, Moure, Aline, Regina de Queiroz Schmidt, Victória, Capriolli, Gabriela, Borowsky Bandeira, Laura, Avila Valandro, Marilia, and Gorczak, Rochelle
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Background: Cystic endometrial hyperplasia is a hormone-dependent disease induced by systemic increase in progesterone that can occur in several domestic species, such as the rabbit. This disease may be associated with sex steroid hormones, especially progesterone, and may be asymptomatic, and it is diagnosed using complementary imaging tests such as total abdominal ultrasound. However, surgical excisional biopsy with histopathological tissue analysis is the gold standard. This study reports a case of asymptomatic cystic endometrial hyperplasia in a female Miniature Lion Lop rabbit (Oryctolagus cuniculus domesticus) treated with therapeutic ovariohysterectomy. Case: A domestic, adult, female Miniature Lion Lop rabbit (Oryctolagus cuniculus domesticus), aged approximately 5 years and weighing 3.2 kg, was referred to specialized care to undergo ovariohysterectomy, an elective procedure. The tutor only reported the occurrence of a single episode of vulvar secretion more than 2 years ago, treated with antibiotics, with remission of clinical signs. In the intraoperative period after celiotomy, the uterine horn and uterine body showed a significant increase in volume, with abnormal color changes and tissue consistency; however, both changes were clinically asymptomatic. Subsequently, biopsy was performed during the ovariohysterectomy procedure. The excised uterus and ovaries were placed in 10% formalin and histopathologically analyzed. The macroscopic histopathological examination of the sectioned tissue revealed a slight amount of brownish fluid inside the uterine horns, in addition to multiple cystic areas in the uterine mucosa. Microscopic examination revealed marked hyperplasia of well-differentiated endometrial epithelial cells, occasionally forming cystic structures of different sizes. Moderate congestion, mild multifocal hemorrhage, and mild multifocal inflammatory infiltrate in the lamina comprising lymphocytes and plasma cells were also observed. Therefore, a diagnosis of cystic endometrial hyperplasia with mild lymphoplasmacytic endometritis was made. Observation of the patient was recommended without therapeutic indication. Discussion: Although the pathogenesis of cystic endometrial hyperplasia remains unknown, it is suggested that it is associated with the presence of sex steroids. Hence, this is a common disease in female rabbits, as they have non-seasonal polyestrous cycles and induced ovulation. Cystic endometrial hyperplasia may be asymptomatic or subclinical, without any significant clinical signs. Conversely, when associated with an infection such as pyometritis, the clinical signs include intermittent hematuria, anemia, lethargy, anorexia, and tenderness in the uterus on palpation. Although diagnosis can be made using total abdominal ultrasound and radiography, it can only be confirmed by the histopathological evaluation of the biopsied uterine tissue. Histopathological features of this disease include endometrial thickening with irregular glandular cystic elevations and hyperplasia of the pseudostratified cylindrical ciliated cells of the uterine glands. Furthermore, lymphoplasmacytic infiltrate is found in the uterine tissue, demonstrating an inflammatory reaction or bacterial infection concomitant with endometrial hyperplasia. In this case, the treatment of choice was therapeutic ovariohysterectomy, which is considered curative in this disease. Thus, ovariohysterectomy can resolve cystic endometrial hyperplasia in a domestic female Miniature Lion Lop rabbit. [ABSTRACT FROM AUTHOR]
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- 2022
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6. Alendronato de sódio tópico associado ao osso bovino liofilizado no reparo ósseo.
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Ramos de OLIVEIRA, Laisa Kindely, da Silva BONATTO, Mariana, Wanderley ROCHA, Stela Maris, Gonzaga RODRIGUES, Fabiano, Moreira FRANÇA, Roberta, Nascimento SILVA, Daniela, and de Assis LIMEIRA JÚNIOR, Francisco
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THROMBOSIS ,TUKEY'S test ,SINUS augmentation ,ALENDRONATE ,BONE grafting ,CALVARIA - Abstract
Copyright of Universidade Estadual Paulista. Revista de Odontologia is the property of Universidade Estadual Paulista. Revista de Odontologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2022
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7. Substituição do milho pelo sorgo sobre o desempenho zootécnico e na digestibilidade em coelhos
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J.M. Parreira Filho, E.A. Fernandes, R.F.M. Guimarães, C.B. Oliveira, B.B.B. Freitas, L.F. Santana, C. Fudimoto, I.F.B. Parreira, and P.M.L. Oliveira
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Zea mays ,Sorghum bicolor ,coelhos ,nutrição ,Animal culture ,SF1-1100 - Abstract
RESUMO O milho é a principal fonte de energia nas dietas animais. Em algumas regiões brasileiras, sua disponibilidade, principalmente na entressafra, é insuficiente para atender à demanda, fazendo com que seu preço se eleve. Neste estudo, objetivou-se avaliar a substituição do milho pelo sorgo sobre o desempenho zootécnico e a digestibilidade em coelhos. Foram utilizados 60 animais machos da raça Nova Zelândia Branco, divididos em três tratamentos: ração base milho (TM); ração base sorgo (TS) e ração base 50% de milho + 50% de sorgo (TMS). No ensaio de desempenho, avaliou-se ganho de peso (GP), consumo de ração (CR), conversão alimentar (CA), coeficientes de digestibilidade da matéria seca (CDMS), proteína bruta (CDPB), fibra em detergente neutro (CDFDN) e fibra em detergente ácido (CDFDA). Observou-se que o CRM, a CA e o GPM não foram afetados pela substituição do milho pelo sorgo, nos níveis de 50% e 100%. Os resultados de digestibilidade demonstraram maiores CDPB e CDFDN na ração base milho, não havendo diferenças entre os demais parâmetros estudados. O sorgo com baixo teor de tanino pode ser usado nas rações de crescimento de coelhos em níveis de substituição de 50% ou 100% da participação do milho, sem prejuízos para o desempenho zootécnico e a digestibilidade.
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- 2020
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8. Monitorização de células-tronco mesenquimais injetadas via retrobulbar próximas ao nervo óptico lesados de coelhos
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Marisa Braga Potério Santucci, Paulo Kharmandayan, Thiago Borsoi Ribeiro, Keila Miriam Monteiro de Carvalho, and Ângela Cristina Malheiros Luzo
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Células tronco mesenquimais ,Nervo óptico ,Neuropatia ,retrobulbar ,Qdots ,Coelhos ,Ophthalmology ,RE1-994 - Abstract
Resumo Objetivo: Verificar a presença das células-tronco mesenquimais (MSC) na área próxima ao nervo óptico de coelhos previamente lesado com álcool absoluto. Métodos: Os 12 coelhos da raça Nova Zelândia foram distribuídos em 2 lotes. Após sedação, cada olho do animal recebeu uma injeção retrobulbar de 1 ml de álcool absoluto em um dos olhos e de 1 ml de solução fisiológica 0,9% (SF) no olho contralateral. Após 15 dias deste procedimento inicial todos os olhos dos animais pertencentes ao lote A, receberam via retrobulbar, uma solução contendo MSC de tecido adiposo humano e previamente marcadas com Qdots,. Todos os olhos dos animais do lote B receberam solução PBS. Resultados: Após 15 dias desta última aplicação os animais foram sacrificados e as lâminas foram analisadas. A presença das MSC foi observada em 100% dos olhos dos animais do lote A. Conclusão: Os resultados sugerem que a marcação prévia das MSC com Qdots permitiu o acompanhamento das mesmas na região aplicada e em áreas mais internas do nervo óptico. A permanência de MSC após 15 dias de aplicação ao redor do nervo óptico sugere a viabilidade e possível participação das mesmas no processo de regeneração do tecido lesado. Nas condições deste estudo, a via de aplicação retrobulbar permitiu a mobilização das células tronco do local de aplicação até áreas centrais dos nervos ópticos nos animais do lote A, sugerindo que esta poderá ser uma via de acesso eficaz para as MSC no processo de regeneração de neuropatias ópticas.
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- 2019
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9. Ocular surface findings in impression cytology after interferon a2b or mitomycin C in rabbits.
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Araújo de Almeida, Simone Ribeiro, Martins, Maria Cristina, de Nadai Barros, Jeison, Lowen, Marcia Serva, Alves Júnior, Milton, and Burnier Jr, Miguel N.
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MITOMYCIN C , *INTERFERONS , *CYTOLOGY , *RABBITS , *CONJUNCTIVA ,RABBIT diseases - Abstract
Objective: To describe ocular surface findings in impression cytology obtained from healthy rabbit conjunctiva treated with interferon alpha-2b eyedrop, and compare them to findings after use of mitomycin C 0.02%. Methods: An experimental study using a rabbit model was performed between September 2013 and October 2014 at the Faculdade de Medicina de Marília, Universidade Federal de São Paulo, Clínica de Olhos Moacir Cunha. Thirty New Zealand white rabbits were divided into 6 groups and received interferon alpha-2b or mitomycin C 0.02%. Impression cytology (IC) was performed prior to topical applications and at15, 30 and 60 days of use. The following variables were analyzed in impression cytology: goblet cells, cellularity, cell-to-cell adhesion, nucleus/cytoplasm ratio, nuclear chromatin, inflammatory cells keratinization, and cytomegaly. Results: The major findings in impression cytology after us of interferon alpha-2b included loss of goblet cells (50.8%), reduced cell-to-cell adhesion (26.2%), abnormal nucleus/cytoplasm ratio (20%) and reduced cellularity (15.4%). After use of mitomycin C 0.02%, the most common changes included loss of goblet cells (46.2%), abnormal nucleus/cytoplasm ratio (25.6%), less cell-to-cell adhesion (23.1%), and reduced cellularity (20.5%). There were no significant differences in any variable when comparing impression cytology after interferon alpha-2b and after mitomycin C 0.02%. Goblet cell loss was more pronounced at days 30 and 60, as compared to impression cytology at day 15 for both drugs. Conclusion: The loss of goblet cells, reduced cell-to-cell adhesion and cellularity, along with abnormal nucleus/cytoplasm ratio were the most common findings in impression cytology after use of interferon alpha-2b.These findings are similar to those described for use of mitomycin C 0.02%. .. [ABSTRACT FROM AUTHOR]
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- 2021
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10. The action of subconjunctival cyclophosphamide in rabbits.
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Almodin, Juliana, Almodin, Flavia, Almodin, Edna, Mendes, Marcio, Cvintal, Tadeu, and Susanna Junior, Remo
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RABBITS , *CYCLOPHOSPHAMIDE , *WATER consumption , *HYPEREMIA , *CONJUNCTIVA - Abstract
Objective: To observe clinically, in rabbits, the side effects of topical injection of subconjunctival cyclophosphamide, studying its role as an antifibrotic drug. Methods: Prospective study in 20 albino rabbits of New Zealand race. All rabbits were treated with cyclophosphamide, 10mg/ml in a volume of 0.3 ml, in the left eye through subconjunctival injection. They were evaluated for 1, 7, 30, and 60 days after the procedure. All the animals were examined for the detection of ocular reactions such as necrosis, hyperemia, chemosis, secretion, opacity, and iritis. Other side effects as changes in the behavior, in the feed, and the water consumption were also evaluated. Results: It was observed that from the 20 rabbits studied, three rabbits (15%) showed side effects only at the 24 hours analysis. One rabbit (5%) presented hyperemia, one rabbit (5%) had hyperemia associated with iritis, and one rabbit (5%) presented hyperemia associated with secretion. These reactions were not observed at 1, 7, 30, and 60 days. Conclusion: Cyclophosphamide subconjunctival injection induces minor side effects on the conjunctiva of rabbits such as hyperemia, associated with iritis and secretion. [ABSTRACT FROM AUTHOR]
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- 2021
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11. Monitoring of stem cells from adipose tissue injected via retrobulbar next to previously injured optic nerve of rabbits.
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Potério Santucci, Marisa Braga, Kharmandayan, Paulo, Borsoi Ribeiro, Thiago, Monteiro de Carvalho, Keila Miriam, and Malheiros Luzo, Ângela Cristina
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OPTIC nerve , *FAT cells , *ADIPOSE tissues , *STEM cells , *MESENCHYMAL stem cells - Abstract
Obtective: To verify the presence of mesenchymal stem cells (MSC) in the area close to the optic nerve of previously injured with absolute alcohol. Methods: Twelve New Zealand breed rabbits were divided into two groups, and after sedation, each eye of the animal received a retrobulbar injection of 1 ml of absolute ethanol in one eye, and 1 ml of physiological solution 0.9 % (PS) in the contralateral eye. After 15 days all eyes of animals belonging to group A, received via retrobulbar a solution containing MSCs from human adipose tissue (AT) and previously marked with Qdots, while all eyes of animals from group B received solution containing PBS. Results: The presence of MSC was observed in 100% of the eyes of the animals of group A and the more central areas near and into the optic nerve. Conclusion: The results suggest that the appointment of MSC with Qdots allowed their follow-up applied in the region and in the inner areas of the optic nerve. The MSC permanence after 15 days of application around the optic nerve suggests the feasibility and possible involvement of the same during the damaged tissue regeneration process. Under the conditions of this study, the route of retrobulbar application and the presence of the stem cells to the central areas of the optic nerves in animals of group A, suggests that this might be an effective approach for MSCs in regeneration process of optic neuropathies. [ABSTRACT FROM AUTHOR]
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- 2019
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12. EX VIVO MODEL OF RABBIT INTESTINAL EPITHELIUM APPLIED TO THE STUDY OF COLONIZATION BY ENTEROAGGREGATIVE ESCHERICHIA COLI
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Ricardo Luís Lopes BRAGA, Ana Claudia Machado PEREIRA, Paula Azevedo dos SANTOS, Angela Corrêa FREITAS-ALMEIDA, and Ana Cláudia de Paula ROSA
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Escherichia coli ,Mucosa intestinal ,ultraestrutura ,Técnicas de cultura de órgãos ,Coelhos ,Microscopia eletrônica de varredura ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
ABSTRACT BACKGROUND The diarrheal syndrome is considered a serious public health problem all over the world and is considered a major cause of morbidity and mortality in developing countries. The high incidence of enteroaggregative Escherichia coli in diarrheal syndromes classified as an emerging pathogen of gastrointestinal infections. After decades of study, your pathogenesis remains uncertain and has been investigated mainly using in vitro models of adhesion in cellular lines. OBJECTIVE The present study investigated the interaction of enteroaggregative Escherichia coli strains isolated from childhood diarrhea with rabbit ileal and colonic mucosa ex vivo, using the in vitro organ culture model. METHODS The in vitro adhesion assays using cultured tissue were performed with the strains co-incubated with intestinal fragments of ileum and colon over a period of 6 hours. Each strain was tested with three intestinal fragments for each region. The fragments were analysed by scanning electron microscopy. RESULTS Through scanning electron microscopy we observed that all strains adhered to rabbit ileal and colonic mucosa, with the typical aggregative adherence pattern of “stacked bricks” on the epithelium. However, the highest degree of adherence was observed on colonic mucosa. Threadlike structures were found in greater numbers in the ileum compared to the colon. CONCLUSION These data showed that enteroaggregative Escherichia coli may have a high tropism for the human colon, which was ratified by the higher degree of adherence on the rabbit colonic mucosa. Finally, data indicated that in vitro organ culture of intestinal mucosa from rabbit may be used to elucidate the enteroaggregative Escherichia coli pathogenesis.
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- 2017
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13. Inflammatory lung injury in rabbits: effects of high-frequency oscillatory ventilation in the prone position
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Jose Roberto Fioretto, Rafaelle Batistella Pires, Susiane Oliveira Klefens, Cilmery Suemi Kurokawa, Mario Ferreira Carpi, Rossano César Bonatto, Marcos Aurélio Moraes, and Carlos Fernando Ronchi
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Respiração artificial/efeitos adversos ,Decúbito ventral ,Pulmão/fisiopatologia ,Pneumonia ,Síndrome do desconforto respiratório do adulto ,Lesão pulmonar aguda ,Modelos animais de doenças ,Coelhos ,Diseases of the respiratory system ,RC705-779 - Abstract
ABSTRACT Objective: To compare the effects that prone and supine positioning during high-frequency oscillatory ventilation (HFOV) have on oxygenation and lung inflammation, histological injury, and oxidative stress in a rabbit model of acute lung injury (ALI). Methods: Thirty male Norfolk white rabbits were induced to ALI by tracheal saline lavage (30 mL/kg, 38°C). The injury was induced during conventional mechanical ventilation, and ALI was considered confirmed when a PaO2/FiO2 ratio < 100 mmHg was reached. Rabbits were randomly divided into two groups: HFOV in the supine position (SP group, n = 15); and HFOV with prone positioning (PP group, n = 15). For HFOV, the mean airway pressure was initially set at 16 cmH2O. At 30, 60, and 90 min after the start of the HFOV protocol, the mean airway pressure was reduced to 14, 12, and 10 cmH2O, respectively. At 120 min, the animals were returned to or remained in the supine position for an extra 30 min. We evaluated oxygenation indices and histological lung injury scores, as well as TNF-α levels in BAL fluid and lung tissue. Results: After ALI induction, all of the animals showed significant hypoxemia, decreased respiratory system compliance, decreased oxygenation, and increased mean airway pressure in comparison with the baseline values. There were no statistically significant differences between the two groups, at any of the time points evaluated, in terms of the PaO2 or oxygenation index. However, TNF-α levels in BAL fluid were significantly lower in the PP group than in the SP group, as were histological lung injury scores. Conclusions: Prone positioning appears to attenuate inflammatory and histological lung injury during HFOV in rabbits with ALI.
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- 2019
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14. Effect of application of fibrin glue on vocal fold healing after surgical manipulation in rabbits
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André de Campos Duprat, Mirna Barros Duarte, Fernanda da Silva Santos, and Felipe Hideo Ikeda
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Larynx ,medicine.medical_specialty ,Fold (higher-order function) ,Fibrin Tissue Adhesive ,Fibrose ,Masson's trichrome stain ,03 medical and health sciences ,0302 clinical medicine ,Cordas vocais ,Fibrosis ,otorhinolaryngologic diseases ,medicine ,030223 otorhinolaryngology ,Fibrin glue ,Fibrin tissue adhesive ,business.industry ,Pedicled Flap ,medicine.disease ,Surgery ,Vocal cords ,Coelhos ,medicine.anatomical_structure ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Vocal folds ,Rabbits ,business ,Laringe ,Adesivo de tecido de fibrina - Abstract
Introduction A challenge in phonosurgery is achieving good vocal quality with minimal vocal fold fibrosis. Fibrin glue can be applied to minimize fibrosis; however, its use in the larynx is based primarily on clinical experience, particularly in extensive lesions. Objective The objective of this study was to evaluate the effect of application of fibrin glue on collagen concentration at the late phase of the healing process after detaching a pedicled flap of the vocal fold cover in rabbits. Methods In this prospective animal study, twelve adult male rabbits underwent laryngeal microsurgery, in which an incision was made along the entire length of both vocal folds, followed by extensive mucosal detachment and section of the incision ends. Fibrin glue was applied in the left vocal fold, and the mucosa was repositioned. In the right vocal fold, the mucosa was repositioned without treatment with fibrin glue. After 3-months, the rabbits were euthanized. Histological analyses were performed, and the data collected were subjected to statistical analysis. Results Vocal folds treated with fibrin glue presented higher collagen concentration in Masson trichrome staining and significantly higher (p< 0.05) collagen concentration in picrosirius red staining compared to control vocal folds. Conclusion Treatment with fibrin glue led to greater vocal fold fibrogenesis in the present study. Nonetheless, further studies are necessary to determine the prophylactic effect of sealants in laryngeal surgeries that require extensive detachment of the vocal fold cover. Resumo Introdução Um desafio na fonocirurgia é conseguir uma boa qualidade vocal com o mínimo de fibrose das pregas vocais. A cola de fibrina pode ser aplicada para minimizar a fibrose; porém, seu uso na laringe é baseado principalmente na experiência clínica, particularmente em lesões extensas. Objetivo Avaliar o efeito da aplicação da cola de fibrina na concentração de colágeno na fase tardia do processo de cicatrização, após o descolamento do retalho pediculado da cobertura da prega vocal em coelhos. Método Neste estudo prospectivo com animais, 12 coelhos adultos machos foram submetidos à microcirurgia de laringe, na qual uma incisão foi feita em toda a extensão de ambas as pregas vocais, seguida de extenso descolamento da mucosa e secção das extremidades da incisão. A cola de fibrina foi aplicada na prega vocal esquerda e a mucosa foi reposicionada. Na prega vocal direita, a mucosa foi reposicionada sem tratamento com cola de fibrina. Após três meses, os coelhos foram sacrificados. Análises histológicas foram feitas e os dados coletados foram submetidos à análise estatística. Resultados As pregas vocais tratadas com cola de fibrina apresentaram maior concentração de colágeno na coloração tricrômica de Masson e concentração significativamente maior de colágeno (p < 0,05) na coloração com picrosirius red comparadas às pregas vocais controle. Conclusão O tratamento com cola de fibrina resultou em maior fibrogênese das pregas vocais no presente estudo. Contudo, novos estudos são necessários para determinar o efeito profilático dos selantes em cirurgias de laringe que requerem extenso descolamento da cobertura das pregas vocais.
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- 2023
15. Ocular delivery of moxifloxacin-loaded liposomes.
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Ferreira, Kaline Sandrelli Amorim, dos Santos, Bruna Marília Alves, de Paiva Lucena, Nelise, Ferraz, Milena Sales, de Siqueira Ferraz Carvalho, Rafaela, Duarte Júnior, Anivaldo Pereira, Magalhães, Nereide Stela Santos, and Lira, Rodrigo Pessoa Cavalcanti
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MOXIFLOXACIN ,QUINOLONE antibacterial agents ,LIPOSOMES ,DRUG delivery systems ,LABORATORY rabbits - Abstract
Copyright of Arquivos Brasileiros de Oftalmologia is the property of Arquivos Brasileiros de Oftalmologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2018
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16. Correlation between systolic function and presence of myofibroblasts in doxorubicin-induced cardiomyopathy
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Fábio Nelson Gava, Sheila Nogueira Saraiva da Silva, Fernando Azadinho Rosa, Edna Mireya Gómez Ortiz, Bruno Cristian Rodrigues, Márcio de Barros Bandarra, Rosemeri de Oliveira Vasconcelos, and Aparecido Antonio Camacho
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α-SMA ,doxorrubicina ,ecodopplercardiografia ,coelhos ,Agriculture ,Agriculture (General) ,S1-972 - Abstract
ABSTRACT: Cardiotoxicity induced by doroxubicin generates systolic disfunction and myocardial remodeling with presence of myofibroblasts. These cells are thought to be attracted to the injured heart to avoid the development of congestive heart failure. The objective of this study was to evaluate the systolic dysfunction generated by doxorubicin through Doppler echocardiography, and its correlation with the presence of myofibroblasts in the myocardium. Twenty-five New Zealand White rabbits were divided into two groups (control, and treated with doxorubicin). The drug was administered for six weeks; Doppler echocardiography was performed before the first, and after the last administration of doxorubicin. Immuno detection of myofibroblasts was performed by immunohistochemistry. The treated group exhibited significant reduction in systolic function as assessed by Doppler echocardiography, and increased frequency of myofibroblasts, which were present in similar amounts in the left ventricle, interventricular septum, and right ventricle. There was a significant negative correlation between number of myofibroblasts in the interventricular septum and in the left ventricle with systolic function indices, which reveals that the higher the number of fibroblasts, the worst systolic function is in rabbits treated with doxorubicin. Increase in myofibroblast numbers was not sufficient to preserve systolic function.
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- 2016
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17. Nanoskin: uso para reposição de volume na cavidade anoftálmica
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Natalia Mussi, Maria Julia de Barros Orsolini, Claudia Helena Pellizon, Carla Adriene da Silva, Silvana Artioli Schellini, Gabriel Molina de Olyveira, and Pierre Basmaji
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Anoftalmia/terapia ,Materiais biocompatíveis ,Celulose/metabolismo ,Próteses e implantes ,Enucleação ocular ,Evisceração do olho ,Coelhos ,Ophthalmology ,RE1-994 - Abstract
RESUMO Objetivo: Avaliar a biocompatibilidade da Nanoskin para reposição de volume em cavidades enucleadas ou evisceradas de coelhos. Métodos: Estudo experimental, utilizando implantes de Nanoskin (Innovatecs®, São Carlos, Brasil), celulose bacteriana produzida pela bactéria Acetobacter xylinum tendo como substrato o chá-verde. Implantes de 10mm de diâmetro/5mm de espessura foram colocados em cavidades enucleadas (G1) ou evisceradas (G2) de 21 coelhos, avaliados clinicamente todos os dias, sacrificados aos 7, 30 e 90 dias após a cirurgia. O material foi removido e preparado para exame de microscopia óptica. Resultados: Sinais flogísticos discretos no pósoperatório imediato, não tendo sido evidenciados sinais infecciosos ou extrusão de nenhum implante. Houve aparente redução do volume ao longo do período experimental. Histologicamente ambos os grupos foram muito semelhantes, apresentando aos 7 dias células inflamatórias (predominantemente monócitos e neutrófilos), rede de fibrina e hemácias. A Nanoskin apresentava-se como pequenas esferas, de cor rósea, com pequenos espaços entre elas, permeados por escassas células inflamatórias. As células inflamatórias se modificaram ao longo de período experimental, sendo possível observar aos 30 dias células gigantes multinucleadas e fibroblastos maduros permeando o implante. Aos 90 dias, a estrutura do implante apresentava-se desorganizada, amorfa, com restos necróticos e com áreas ovoides, revestidas por fina membrana rósea, que pareciam se agrupar, vazias ou preenchidas por material acelular, róseo ou acinzentado. Conclusão: A Nanoskin provocou reação inflamatória que levou à reabsorção e redução do volume do implante. Novas formulações devem ser estudadas a fim de ter um produto que seja permanente para reparo da cavidade anoftálmica.
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- 2016
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18. Isolation, expansion and differentiation of mesenchymal stromal cells from rabbits' bone marrow
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Renato B. Eleotério, Rodrigo V. Sepúlveda, Emily C.C. Reis, Fabrício L. Valente, and Andréa P.B. Borges
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Células tronco mesenquimais ,medula óssea ,coelhos ,terapia celular ,engenharia de tecidos ,medicina regenerativa. ,Veterinary medicine ,SF600-1100 - Abstract
Abstract: Tissue engineering has been a fundamental technique in the regenerative medicine field, once it permits to build tri-dimensional tissue constructs associating undifferentiated mesenchymal cells (or mesenchymal stromal cells - MSCs) and scaffolds in vitro. Therefore, many studies have been carried out using these cells from different animal species, and rabbits are often used as animal model for in vivo tissue repair studies. However, most of the information available about MSCs harvesting and characterization is about human and murine cells, which brings some doubts to researchers who desire to work with a rabbit model in tissue repair studies based on MSCs. In this context, this study aimed to add and improve the information available in the scientific literature providing a complete technique for isolation, expansion and differentiation of MSCs from rabbits. Bone marrow mononuclear cells (BMMCs) from humerus and femur of rabbits were obtained and to evaluate their proliferation rate, three different culture media were tested, here referred as DMEM-P, DMEM´S and α-MEM. The BMMCs were also cultured in osteogenic, chondrogenic and adipogenic induction media to prove their multipotentiality. It was concluded that the techniques suggested in this study can provide a guideline to harvest and isolate MSCs from bone marrow of rabbits in enough amount to allow their expansion and, based on the laboratory experience where the study was developed, it is also suggested a culture media formulation to provide a better cell proliferation rate with multipotentiality preservation.
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- 2016
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19. Method to obtain platelet-rich plasma from rabbits (Oryctolagus cuniculus )
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Josiane M. Pazzini, Andrigo B. De Nardi, Rafael R. Huppes, Ana P. Gering, Marília G.P.A. Ferreira, Camila P.B. Silveira, Mayara C. Luzzi, and Romeu Santos
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Plasma rico em plaquetas ,concentração plaquetária ,neovascularização ,coelhos ,Veterinary medicine ,SF600-1100 - Abstract
Abstract: Platelet-rich plasma (PRP) is a product easy and inxpesnsive, and stands out to for its growth factors in tissue repair. To obtain PRP, centrifugation of whole blood is made with specific time and gravitational forces. Thus, the present work aimed to study a method of double centrifugation to obtain PRP in order to evaluate the effective increase of platelet concentration in the final product, the preparation of PRP gel, and to optimize preparation time of the final sample. Fifteen female White New Zealand rabbits underwent blood sampling for the preparation of PRP. Samples were separated in two sterile tubes containing sodium citrate. Tubes were submitted to the double centrifugation protocol, with lid closed and 1600 revolutions per minute (rpm) for 10 minutes, resulting in the separation of red blood cells, plasma with platelets and leucocytes. After were opened and plasma was pipetted and transferred into another sterile tube. Plasma was centrifuged again at 2000rpm for 10 minutes; as a result it was split into two parts: on the top, consisting of platelet-poor plasma (PPP) and at the bottom of the platelet button. Part of the PPP was discarded so that only 1ml remained in the tube along with the platelet button. This material was gently agitated to promote platelets resuspension and activated when added 0.3ml of calcium gluconate, resulting in PRP gel. Double centrifugation protocol was able to make platelet concentration 3 times higher in relation to the initial blood sample. The volume of calcium gluconate used for platelet activation was 0.3ml, and was sufficient to coagulate the sample. Coagulation time ranged from 8 to 20 minutes, with an average of 17.6 minutes. Therefore, time of blood centrifugation until to obtain PRP gel took only 40 minutes. It was concluded that PRP was successfully obtained by double centrifugation protocol, which is able to increase the platelet concentration in the sample compared with whole blood, allowing its use in surgical procedures. Furthermore, the preparation time is appropriate to obtain PRP in just 40 minutes, and calcium gluconate is able to promote the activation of platelets.
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- 2016
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20. Morphological, comparative and qualitative tissue reaction analysis due to the implantation of alloplant™ to the eyelid and subcutaneous of rabbits
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Carmen Silvia Bongiovanni de Miranda Gonçalves, Moacyr Pezati Rigueiro, and Marinho Jorge Scarpi
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Implantes experimentais ,Histologia ,Pálpebras ,Procedimentos cirúrgicos ambulatórios ,Microscopia ,Coelhos ,Ophthalmology ,RE1-994 - Abstract
ABSTRACT Purpose: To compare by optical microscopy, tissue reaction caused by the Alloplant ™ to conjunctiva and backs of 24 rabbits. Methods: All rabbits underwent implantation of Alloplant ™ on the inner third of the lower eyelid, replacing the tarsal conjunctiva of one eye. After thirty days six rabbits (Group I) were sacrificed and lower eyelids of both sides and a back fragment (control) routed to optical microscopy. After sixty days six rabbits (group II) were sacrificed and their eyelids and a back fragment (control) sent for microscopic examination. That day were also performed surgical implantation of Alloplant ™ on the back of the twelve remaining rabbits. They were sacrificed ninety days (group III) and one hundred and twenty days (group IV) after the first surgery of the eyelids and microscopic study backs. Results: The “Alloplant™” (aloimplante), caused an intense inflammatory reaction, mixed exudative and proliferative with a predominance of lymphocytes, macrophages and formation of foreign body granulomas in both locations, which evolved with the replacement of the implant by dense fibrous connective tissue. Conclusion: eyelid inflammatory reaction was more intense and more prolonged in the eyelid than in the back. In the back the formation of fibrosis was more intense, what is not suitable for eyelid surgery.
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- 2015
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21. Biological parameters of Amblyomma coelebs Neumann, 1906 (Acari: Ixodidae) under experimental conditions
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André de Abreu Rangel Aguirre, Vinicius da Silva Rodrigues, Ivaneide Nunes da Costa, Marcos Valerio Garcia, Leandro de Oliveira Souza Higa, Jansen Fernandes Medeiros, and Renato Andreotti
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Amblyomma coelebs ,ciclo de vida ,parâmetros biológicos ,condições experimentais ,coelhos ,Animal culture ,SF1-1100 - Abstract
Abstract One generation of Amblyomma coelebs life cycle under experimental conditions was evaluated. Ten tick pairs were allowed to feed on rabbits under laboratory conditions (LC), resulting six engorged females with a mean weight of 1,403.9 mg. Two females were maintained in a forest reserve under natural conditions (NC), and four were maintained in incubators (LC). The engorgement period lasted 10.33 days. Pre-oviposition periods were 10.75 (NC) and 22 days (LC). The mean egg-mass weight was 514.76 mg, and the blood meal conversion index was 36.67% (LC). Incubation period under NC and LC were 91 and 56.33 days and hatching rates were 50% and 28.33%, respectively. Larval engorgement period ranged from 4 to 10 days, with average weight of 1.1 mg. Engorged larvae were incubated under NC and LC, with a premolt period of 27 to 36 days and molting rate of 7.1% and 28.7%, respectively. Nymphal engorgement period ranged from 5 to 7 days, with a mean weight of 18.8 mg and a recovery rate of 54.54%. In LC, the ecdysis mean period was 24.5 days, and molting rate was 44.44%, resulting in 24 adult A. coelebs. Our results show a life cycle of 187.45 (NC) and 149 (LC) days.
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- 2018
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22. Metabolismo do cálcio em coelhos (Oryctolagus cuniculus): Revisão de Literatura
- Abstract
Calcium is a mineral found mainly in the bones and teeth of animals. It is responsible for several activities such as: muscle contraction, blood clotting, selective permeability of cell membranes, enzymatic activities and hormonal release. Its metabolism is complex and involves the participation of parathormone, calcitriol and vitamin D. In rabbits, this metabolism is distinct from other mammals. Thus, the present literature review aims toaddress the peculiarities of calcium metabolism that occurs in rabbits., O cálcio é um mineral encontrado principalmente em ossos e dentes dos animais. Ele é responsável por diversas atividades como: contração muscular, coagulação sanguínea, permeabilidade seletiva das membranas celulares, atividades enzimáticas e liberação hormonal. O seu metabolismo é complexo e envolve a participação do paratormônio, calcitriol evitamnina D. Em coelhos, esse metabolismo é distinto dos demais mamíferos. Dessa forma, a presente revisão bibliográfica visa abordar as peculiaridades do metabolismo do cálcio que ocorre em coelhos.
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- 2022
23. Metabolismo do cálcio em coelhos (Oryctolagus cuniculus): Revisão de Literatura
- Abstract
Calcium is a mineral found mainly in the bones and teeth of animals. It is responsible for several activities such as: muscle contraction, blood clotting, selective permeability of cell membranes, enzymatic activities and hormonal release. Its metabolism is complex and involves the participation of parathormone, calcitriol and vitamin D. In rabbits, this metabolism is distinct from other mammals. Thus, the present literature review aims toaddress the peculiarities of calcium metabolism that occurs in rabbits., O cálcio é um mineral encontrado principalmente em ossos e dentes dos animais. Ele é responsável por diversas atividades como: contração muscular, coagulação sanguínea, permeabilidade seletiva das membranas celulares, atividades enzimáticas e liberação hormonal. O seu metabolismo é complexo e envolve a participação do paratormônio, calcitriol evitamnina D. Em coelhos, esse metabolismo é distinto dos demais mamíferos. Dessa forma, a presente revisão bibliográfica visa abordar as peculiaridades do metabolismo do cálcio que ocorre em coelhos.
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- 2022
24. Osmolaridade lacrimal e superfície ocular em modelo de olho seco por toxicidade
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Davi Lazarini Marques, Mônica Alves, Carolina Maria Modulo, Lilian Eslaine Costa Mendes da Silva, and Peter Reinach
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Síndromes do olho seco/induzido quimicamente ,Concentração osmolar ,Lágrimas/metabolismo ,Compostos de benzalcônio/toxicidade ,Modelos animais ,Coelhos ,Ophthalmology ,RE1-994 - Abstract
Objetivo: Descrever um modelo animal de olho seco induzido pela aplicação tópica de cloreto de benzalcônio (BAC) e avaliar marcadores de integridade da superfície ocular e os achados histológicos. Métodos: Foram utilizados ratos wistar machos adultos. Foi realizada a administração tópica de colírio de BAC 0,2% no olho direito de cada animal duas vezes por dia, durante 7 dias, sendo o olho contralateral tido como controle. Após o tratamento foi realizada a avaliação da osmolaridade do filme lacrimal, o teste de fenol vermelho e a coloração com fluoresceína e lisamina verde. Os animais foram sacrificados e os tecidos extraídos para o estudo histológico da córnea, por microscopia óptica, corada com hematoxilina eosina (H&E). Resultados: Comparados com os controles não tratados o grupo BAC apresentou diminuição significativa na secreção lacrimal, defeitos na integridade epitelial da superfície ocular marcada por corantes vitais, fluoresceína e lisamina verde além do aumento da osmolaridade do filme lacrimal (p < 0,05). À avaliação histológica observou-se diminuição da espessura do epitélio e edema estromal induzidos pela aplicação de BAC. Conclusão: O modelo animal de olho seco por toxicidade induzido pela aplicação tópica de cloreto de benzalcônio apresentou alterações estruturais da córnea e da superfície ocular, diminuição do volume lacrimal e hiperosmolaridade da lágrima características dessa condição.
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- 2015
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25. Evaluation of the ability of an experimental model to induce bacterial rhinosinusitis in rabbits
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Eduardo Landini Lutaif Dolci, Carlos Augusto Correia de Campos, Leonardo da Silva, Ricardo Landini Lutaif Dolci, and José Eduardo Lutaif Dolci
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Sinusite ,Modelos animais ,Coelhos ,Otorhinolaryngology ,RF1-547 - Abstract
Introduction: For decades, animals have been used in sinonasal experimental models, and the practice has increased substantially in the last few years. This study aimed to assess the pathogenesis of infectious process and medication efficiency to treat rhinosinusitis. Objective: To evaluate the efficiency of the proposed experimental model to induce an acute bacterial sinonasal infectious process through histological analysis and sinus secretion cultures. Methods: This was an experimental study with 22 New Zealand rabbits, divided into: group A (six rabbits), group B (seven rabbits), group C (seven rabbits), and group D (control group with two rabbits). Rhinosinusitis was induced by the insertion of a synthetic sponge into the right nasal cavity of 20 animals (study groups), followed by the instillation of bacterial strains (50% Staphylococcus sp. and 50% Streptococcus sp.). The groups were euthanized within 10 days (group A), 17 days (group B), and 30 days (groups C and D). Results: All the rabbits of the study group developed acute bacterial rhinosinusitis, which was diagnosed through macroscopic evaluation, histological analysis, and sinus secretion culture. Conclusion: The proposed model is technically simple to perform, it is similar to the rhinogenic model in human beings, and it is highly efficient to reproduce an acute bacterial sinus infection.
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- 2014
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26. Review of experimental models: sinusitis in rabbits
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André Coura Perez, Guilherme Pietrucci Buzatto, Ivan de Picole Dantas, João Vicente Dorgam, Fabiana Cardoso Pereira Valera, Edwin Tamashiro, and Wilma Terezinha Anselmo Lima
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Sinusite ,Coelhos ,Pólipos ,Otorhinolaryngology ,RF1-547 - Abstract
INTRODUCTION: In order to better understand the pathophysiology of rhinosinusitis, several attempts have been made to create the disease in an animal model. Among the studied rodents each has its advantages and disadvantages. Rabbits are considered more appropriate for studies that require surgical manipulation or invasive procedures. OBJECTIVES: To evaluate the most viable experimental model of rhinosinusitis in rabbits to be adopted in future studies. METHODS: An electronic search for studies with experimental models of rhinosinusitis in rabbits published in English and Portuguese between July of 1967 and January of 2013 was conducted in Medline, Pub Med, Cochrane, and CAPES databases, using the keywords "sinusitis", "rabbits", and "polyps". RESULTS: A total of 256 studies were retrieved, but in accordance with the inclusion and exclusion criteria, only ten studies were selected. Many different methods of response assessment were used in these studies. CONCLUSION: To date, there is no ideal experimental model for induction of acute or chronic rhinosinusitis in rabbits, but the rhinogenic model appears to be the most viable option for the continuity of studies of the disease.
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- 2014
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27. Retinal changes in rabbit after intravitreal injection of sunitinib encapsulated into solid lipid nanoparticles and polymeric nanocapsules.
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de Freitas, Luiz Guilherme Azevedo, Isaac, David Leonardo Cruvinel, Lima, Eliana Martins, Souza, Leonardo Gomes, Abud, Murilo Alves, dos Reis, Ricardo Gomes, Tannure, William Thomas, and de Ávila, Marcos Pereira
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NANOCAPSULES ,NANOBIOTECHNOLOGY ,RETINAL degeneration ,IMMUNOSUPPRESSIVE agents ,EYE drops - Abstract
Copyright of Arquivos Brasileiros de Oftalmologia is the property of Arquivos Brasileiros de Oftalmologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2018
- Full Text
- View/download PDF
28. Autologous and homologous skin grafts treated with platelet-rich plasma (PRP): experimental study in rabbits.
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Kemper, Bernardo, Brandão, Cláudia V. S., Rossetto, Victor J. V., Gushiken, Lucas F. S., Padovani, Carlos R., and Pellizzon, Claudia H.
- Abstract
Copyright of Pesquisa Veterinaria Brasileira is the property of Colegio Brasileiro de Patologia Animal - CBPA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2018
- Full Text
- View/download PDF
29. Establishment of an experimental model of small intestinal ischemia and reperfusion injuries in New Zealand rabbits.
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Oliveira, Alvaro P. L., Rangel, Julia P. P., Riodades, Luiz F. S., Almeida, Bruna L., Mathias, Carlos Henrique T., Conti, Laura M. C., Fiorio, Wagner A. B., and Monteiro, Betânia S.
- Abstract
Copyright of Pesquisa Veterinaria Brasileira is the property of Colegio Brasileiro de Patologia Animal - CBPA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2018
- Full Text
- View/download PDF
30. Avaliação das fibras colágenas de feridas dérmicas de coelhos tratadas com diferentes fontes de plasma rico em plaquetas.
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Ferraciolli, E., Laposy, C. B., Nogueira, M. R., Justulin Júnior, L. A., Camargo Filho, J. C., Moreira, V., Marques, M. E., Nai, G., and Ozaki, G.
- Abstract
Copyright of Arquivo Brasileiro de Medicina Veterinaria e Zootecnia is the property of Universidade Federal de Minas Gerais, Escola de Veterinaria and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2018
- Full Text
- View/download PDF
31. Antiscarring effect of intraoperative bevacizumab in experimental glaucoma filtration surgery.
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Rebello Hilgert, Christiana, Haverroth Hilgert, Alvaro, Odashiro, Alexandre Nakao, Pereira Odashiro, Patricia Rusa, and Paranhos Jr., Augusto
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BEVACIZUMAB ,GLAUCOMA ,INTRAOPERATIVE care ,WOUND healing ,RABBITS - Abstract
Copyright of Arquivos Brasileiros de Oftalmologia is the property of Arquivos Brasileiros de Oftalmologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2018
- Full Text
- View/download PDF
32. The study of the use of a latex biomembrane and conjunctival autograft in rabbit conjunctiva wound healing.
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Canarim Martha de Pinho, Erika Christina, Chahud, Fernando, Lachat, João-José, Coutinho-Netto, Joaquim José, and Faria e Sousa, Sidney Julio
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LATEX ,BIOLOGICAL membranes ,AUTOTRANSPLANTATION ,TRANSPLANTATION of organs, tissues, etc. ,EYE diseases ,THERAPEUTICS - Abstract
Copyright of Arquivos Brasileiros de Oftalmologia is the property of Arquivos Brasileiros de Oftalmologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2018
- Full Text
- View/download PDF
33. Matrix metalloproteinases 2 and 9 in rabbits with doxorubicin-induced cardiomyopathy.
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Nogueira, Sheila S. S., Sousa, Marlos G., Gava, Fabio N., Rosa, Fernando A., Melo, Guilherme D., Dittrich, Gustavo, Machado, Gisele F., and Camacho, Aparecido A.
- Abstract
Copyright of Pesquisa Veterinaria Brasileira is the property of Colegio Brasileiro de Patologia Animal - CBPA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2018
- Full Text
- View/download PDF
34. Aspecto morfológico da interface entre o compósito, constituído de quitosana e polimetilmetacrilato, e a falha óssea de tíbia de coelhos.
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Kuhl, Gabriela S., Rigo, Eliana C. S., Vercik, Luci C. O., Dória, Renata G. S., Santos, Marcelo D., Hage, Maria C. F. N. S., Ambrósio, Carlos E., and Freitas, Silvio H.
- Abstract
Copyright of Pesquisa Veterinaria Brasileira is the property of Colegio Brasileiro de Patologia Animal - CBPA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2017
- Full Text
- View/download PDF
35. Comparison between conventional protective mechanical ventilation and high-frequency oscillatory ventilation associated with the prone position.
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Fioretto, José Roberto, Klefens, Susiane Oliveira, Pires, Rafaelle Fernandes, Kurokawa, Cilmery Suemi, Carpi, Mario Ferreira, Bonatto, Rossano César, Moraes, Marcos Aurélio, and Ronchi, Carlos Fernando
- Subjects
- *
TRACHEOTOMY , *ARTIFICIAL respiration , *LUNG injuries , *THERAPEUTICS - Abstract
Objective: To compare the effects of high-frequency oscillatory ventilation and conventional protective mechanical ventilation associated with the prone position on oxygenation, histology and pulmonary oxidative damage in an experimental model of acute lung injury. Methods: Forty-five rabbits with tracheostomy and vascular access were underwent mechanical ventilation. Acute lung injury was induced by tracheal infusion of warm saline. Three experimental groups were formed: healthy animals + conventional protective mechanical ventilation, supine position (Control Group; n = 15); animals with acute lung injury + conventional protective mechanical ventilation, prone position (CMVG; n = 15); and animals with acute lung injury + high-frequency oscillatory ventilation, prone position (HFOG; n = 15). Ten minutes after the beginning of the specific ventilation of each group, arterial gasometry was collected, with this timepoint being called time zero, after which the animal was placed in prone position and remained in this position for 4 hours. Oxidative stress was evaluated by the total antioxidant performance assay. Pulmonary tissue injury was determined by histopathological score. The level of significance was 5%. Results: Both groups with acute lung injury showed worsening of oxygenation after induction of injury compared with the Control Group. After 4 hours, there was a significant improvement in oxygenation in the HFOG group compared with CMVG. Analysis of total antioxidant performance in plasma showed greater protection in HFOG. HFOG had a lower histopathological lesion score in lung tissue than CMVG. Conclusion: High-frequency oscillatory ventilation, associated with prone position, improves oxygenation and attenuates oxidative damage and histopathological lung injury compared with conventional protective mechanical ventilation. [ABSTRACT FROM AUTHOR]
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- 2017
- Full Text
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36. Análise clínica e histopatológica de um implante de polimetilmetacrilato oco e multiperfurado em sua porção posterior em olhos eviscerados de coelhos
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Silva,Marlos R Lopes e, Chahud,Fernando, and Cruz,Antonio Augusto V.
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Eye evisceration ,Polymethylmethacrylate ,Orbital implants ,Anophthalmos ,Ophthalmological surgical procedures ,General Medicine ,Implantes orbitários ,Coelhos ,Polimetilmetacrilato ,Ophthalmology ,Anoftalmia ,Evisceração ocular ,Rabbits ,Procedimentos cirúrgicos oftalmológicos - Abstract
Purpose: The study aimed to evaluate the clinical and tissue response to a hollow polymethylmethacrylate orbital implant with a multiperforated posterior surface in an animal model after evisceration. Methods: Sixteen New Zealand rabbits had their right eye eviscerated. All animals received a hollow polymethylmethacrylate implant 12 mm in diameter that is multiperforated in its posterior hemisphere. The animals were divided into four groups, and each one had the eye exenterated at 7, 30, 90, and 180 days post-evisceration. Clinical signs were assessed daily for 14 days post-evisceration and then every 7 days until 180 days. Inflammatory pattern, collagen structure, and degree of neovascularization generated with implant placement were analyzed with hematoxylin-eosin, picrosirius red, and immunohistochemistry staining. Results: There were no signs of infection, conjunctival or scleral thinning, or implant exposure or extrusion in any animal during the study. On day 7, the new tissue migrated into the implant and formed a fibrovascular network through the posterior channels. Inflammatory response reduced over time, and no multinucleated giant cells were found at any time. Conclusion: Hollow polymethylmethacrylate orbital implants with a multiperforated posterior surface enable rapid integration with orbital tissues by fibrovascular ingrowth. We believe that this orbital implant model can be used in research on humans. RESUMO Objetivo: Avaliar a resposta tecidual e clínica a um implante orbitário de polimetilmetacrilato, oco e multiperfurado em sua porção posterior em modelo animal após evisceração. Métodos: Dezesseis coelhos da raça Nova Zelândia foram submetidos à evisceração do globo ocular direito. Todos receberam implante oco de polimetilmetacrilato de 12 mm de diâmetro, multiperfurado em sua semiesfera posterior. O estudo foi dividido em avaliação clínica e histopatológica. A avaliação clínica foi diária até 14 dias pós-evisceração e, a cada sete dias, até completar 180 dias. Os animais foram divididos em grupos de quatro animais e cada um foi submetido à exenteração com 07, 30, 90 e 180 dias e depois à eutanásia. A análise histopatológica teve por fim caracterizar o padrão inflamatório, a estrutura do colágeno e o grau de neovascularização. Para isso, além da tradicional coloração pela hematoxilina-eosina, utilizou-se o corante Picrosirius Red (PSR) e imuno-histoquímica com o marcador CD 34. Resultados: Não houve sinais de infecção, afinamento conjuntival ou escleral, exposição ou extrusão do implante em nenhum animal durante o estudo. Já no sétimo dia, o tecido neoformado migrou para dentro do implante formando uma rede fibrovascular através dos canais posteriores. A resposta inflamatória diminuiu ao longo do tempo avaliado e não foram encontradas células gigantes multinucleadas. Conclusão: O implante analisado permite a sua integração aos tecidos orbitários pelo crescimento fibrovascular em seu interior. Os autores acreditam que este modelo de implante orbital pode fazer parte de testes com humanos.
- Published
- 2022
37. Effect of Pitavastatin on Vascular Reactivity in Hypercholesterolemic Rabbits
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Eros Antonio de Almeida and Michiko Regina Ozaki
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Inibidores de Hidroximetilglutaril - CoA Redutases ,Disfunção Endotelial ,Coelhos ,Hipercolesterolemia ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: Pitavastatin is the newest statin available in Brazil and likely the one with fewer side effects. Thus, pitavastatin was evaluated in hypercholesterolemic rabbits in relation to its action on vascular reactivity. Objective: To assess the lowest dose of pitavastatin necessary to reduce plasma lipids, cholesterol and tissue lipid peroxidation, as well as endothelial function in hypercholesterolemic rabbits. Methods: Thirty rabbits divided into six groups (n = 5): G1 - standard chow diet; G2 - hypercholesterolemic diet for 30 days; G3 - hypercholesterolemic diet and after the 16th day, diet supplemented with pitavastatin (0.1 mg); G4 - hypercholesterolemic diet supplemented with pitavastatin (0.25 mg); G5 - hypercholesterolemic diet supplemented with pitavastatin (0.5 mg); G6 - hypercholesterolemic diet supplemented with pitavastatin (1.0 mg). After 30 days, total cholesterol, HDL, triglycerides, glucose, creatine kinase (CK), aspartate aminotransferase (AST), alanine aminotransferase (ALT) were measured and LDL was calculated. In-depth anesthesia was performed with sodium thiopental and aortic segments were removed to study endothelial function, cholesterol and tissue lipid peroxidation. The significance level for statistical tests was 5%. Results: Total cholesterol and LDL were significantly elevated in relation to G1. HDL was significantly reduced in G4, G5 and G6 when compared to G2. Triglycerides, CK, AST, ALT, cholesterol and tissue lipid peroxidation showed no statistical difference between G2 and G3-G6. Significantly endothelial dysfunction reversion was observed in G5 and G6 when compared to G2. Conclusion: Pitavastatin starting at a 0.5 mg dose was effective in reverting endothelial dysfunction in hypercholesterolemic rabbits.
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- 2014
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38. A new surgical technique to treat corneal perforations using amniotic membrane and surgical adhesive
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K.C.S. Pontes, A.P.B. Borges, R.B. Eleotério, A.C.N. Frazão, D.P.D. Machado, E.C.C. Reis, R.V. Sepúlveda, T.S. Duarte, and J.L. Laus
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coelhos ,córnea ,cianoacrilato ,glicerina ,cirurgia oftálmica ,Animal culture ,SF1-1100 - Abstract
The objectives of this study were to compare surgical techniques and the effects of using n-butyl 2-cyanoacrylate and bovine amniotic membrane to repair perforated lesions in corneas. Penetrating keratoplasty was performed in sixty New Zealand White rabbits under general anesthesia. Group 1 (G1) was treated with n-butyl 2-cyanoacrylate, group 2 (G2) received a fragment of amniotic membrane through the anterior chamber and application of n-butyl 2-cyanoacrylate over the lesion, group 3 (G3) was treated with the same technique as G2 with the addition of an amniotic membrane bandage covering the cornea and sutured in the limbus region, and group 4 (G4) was treated with an amniotic membrane sutured to the lesion and an amniotic membrane bandage sutured in the limbus region. Clinical, histological and histomorphometric examinations of the corneas were performed. The membrane acted as a barrier for aqueous humor in G2 and G3, thereby keeping the surface dry for adhesive application; it also prevented the adhesive from contacting intraocular structures. The groups treated with amniotic membrane and surgical adhesive showed better results than the groups treated with either material alone. Thus, the combination of the membrane with the adhesive is recommended for this type of lesion.
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- 2014
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39. Influência da aplicação intraoperatória de mitomicina C tópica episcleral na proliferação e diferenciação de células epiteliais córneo-conjuntivais de coelhos
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Marisa Braga Potério, Newton Kara José, Eliane Maria Ingrid Amstalden, Keila Miriam Monteiro de Carvalho, and Ana Maria Marcondes
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Córnea ,Células epiteliais/efeito de drogas ,Mitomicina/administração & dosagem ,Coelhos ,Ophthalmology ,RE1-994 - Abstract
Objetivo: Avaliar a influência da mitomicina C a 0,02% (MMC), aplicada em dose única por 3 minutos, na proliferação e diferenciação das células epiteliais da córnea de coelhos. Métodos: A MMC tópica foi aplicada na episclera da área límbica temporal, mediante tecido epitelial corneano intacto (um olho) e após desepitelização epitelial parcial da córnea (outro olho). Durante o procedimento cirúrgico, MMC ou solução fisiológica 0,9% (SF) foi aplicada e a solução escolhida para cada animal foi determinada por sorteio. Os animais foram divididos em grupo A (20 olhos), grupo B (16 olhos) e grupo C (14 olhos). Foram sacrificados respectivamente em 4º, 15º e 45º dia de pós-operatório. Para estimular a proliferação celular, os animais do grupo C foram submetidos à desepitelização central da córnea 3 dias antes do dia do sacrifício. Marcadores de diferenciação celular (AE1, AE3 e AE5) e de proliferação (5Bromo-2-Deoxiuridina, BrdU) foram utilizados. Nas lâminas coradas com BrdU, as áreas nasal, temporal e central foram delimitadas. O número de células coradas pela BrdU foram contadas nos 3 diferentes campos e a média aritmética de cada área foi analisada estatisticamente. Resultados: Houve diferença estatística entre MMC e SF nas áreas central e temporal da córnea previamente desepitelizada em todos os grupos. Não houve diferença estatística durante a análise de diferenciação celular. Conclusão: A MMC na dose de 0,02%, aplicada por 3 minutos sobre a episclera, interfere na proliferação celular da área exposta à droga e previamente desepitelizada. Não interfere na diferenciação celular e sua ação possui efeito prolongado.
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- 2014
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40. Estudo experimental da utilização de cartilagem auricular com e sem Gelfoam® em dorso nasal em coelhos
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Breno Simões Ribeiro da Silva and José Eduardo Lutaif Dolci
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Coelhos ,Reconstrução ,Nariz ,Cartilagem ,Orelha ,Otorhinolaryngology ,RF1-547 - Abstract
Introdução: Existem inúmeros materiais para reconstrução de deformidades do dorso nasal que Orelha são divididos em quatro categorias: enxertos autólogos, homólogos, heterólogos e aloplásticos. Objetivo: Comparar as condições através do tempo das reações inflamatórias do enxerto de cartilagem auricular com e sem Gelfoam® quando colocadas no dorso nasal de coelhos. Método: Foram estudados 30 coelhos, em dois grupos de 15 coelhos cada (Grupo com cartilagem e Grupo com cartilagem mais Gelfoam®) e em seguida subdivididos em três sub grupos de 7, 30 e 60 dias de seguimento onde os enxertos de 1,5 centímetro de comprimento e 0,5 de largura eram colocados metade com Gelfoam® e outra metade sem Gelfoam® na bolsa de enxertia sobre o dorso nasal de coelhos. Após o período determinado, os coelhos de cada grupo foram submetidos à eutanásia e a seguir os enxertos foram submetidos a estudo histológico. Resultados: O grupo experimental foram os que mais apresentaram neovascularização e formação de tecido de granulação e em relação a presença de processo inflamatório agudo e crônico, os resultados se mostraram praticamente iguais tanto nos coelhos do modelo controle quanto no experimental em todos os três grupos. Conclusão: Não há diferença estatística entre os grupos.
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- 2014
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41. Aspecto radiológico e macroscópico de matriz óssea mineralizada heteróloga fragmentada e polimetilmetacrilato autoclavados em falha óssea de tíbia de coelho
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Roberto Moreira, Renata G.S. Dória, Lázaro M. Camargo, Marcelo D. Santos, Bruno W. Minto, Andrigo B. De Nardi, Carlos E. Ambrósio, and Silvio H. Freitas
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Biomateriais ,coelhos ,matriz óssea ,osteocondução ,polimetilmetacrilato ,Veterinary medicine ,SF600-1100 - Abstract
Foi realizada falha segmentar com 6mm de diâmetro na região metafisária medial de tíbias de 12 coelhos, onde foi implantado uma associação de micro e macrofragmentos de matriz óssea cortical heteróloga fragmentada conservada em glicerina (98%) e polimetilmetacrilato autoclavados, para a sua reconstrução, e avaliados radiológica e macroscopicamente aos 30, 60, 90 e 120 dias. Houve adesão, em relação ao tempo, dos micro e macrocompósitos ao leito receptor, em 100% dos casos, mostrando ser biologicamente biocompatível, pois promoveram a reparação de falhas ósseas, sem sinais de infecção, migração e/ou rejeição, podendo, dessa forma, ser mais uma opção como substituto para preencher grandes defeitos ósseos.
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- 2014
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42. Efeito dos ácidos hialurônicos como condroprotetores em modelo experimental de osteoartrose
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Marcello Zaia Oliveira, Mauro Batista Albano, Mario Massatomo Namba, Luiz Antônio Munhoz da Cunha, Renan Rodrigues de Lima Gonçalves, Edvaldo Silva Trindade, Lucas Ferrari Andrade, and Leandro Vidigal
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Osteoartrose ,Ácido hialurônico ,Ligamento cruzado anterior ,Joelho ,Coelhos ,Medicine ,Orthopedic surgery ,RD701-811 - Abstract
Objetivo: analisar os efeitos do ácido hialurônico de diferentes pesos moleculares em modelo experimental de osteoartrose em coelhos. Métodos: foram alojados de modo aleatório 44 coelhos da raça California, machos, em três grupos (PR, S e P) e submetidos a ressecção do ligamento cruzado anterior do joelho direito. Decorridas três semanas do procedimento cirúrgico iniciaram-se as três injeções intra-articulares semanais de ácido hialurônico nativo (Polireumin®)-PR, ácido hialurônico de cadeia ramificada (Synvisc®)-S e soro fisiológico 0,9%-P. Todos os animais foram sacrificados após 12 semanas do ato cirúrgico e os platôs tibiais dos joelhos infiltrados foram dissecados. Cortes histológicos da cartilagem das áreas de apoio com maior espessura dos platôs tibiais foram corados com Alcian Blue pH = 1,0, Alcian Blue pH = 2,5 e Azul de Toluidina para pesquisa da quantidade de proteoglicanos. A intensidade de coloração foi quantificada em um aparelho de microscopia ZeissImager Z2 Metasystems e analisada pelo software MetaferMsearch. A análise estatística consistiu no uso dos testes Kolmorov-Smirnov, análise de variância (Anova), t de Student e qui-quadrado. O nível de significância usado foi de 5%. Resultado: o efeito condroprotetor dos ácidos hialurônicos usados no estudo foi demonstrado quando comparado ao do grupo controle, porém, feita a comparação entre si, não houve diferença estatística quanto à condroproteção. Conclusão: os ácidos hialurônicos testados obtiveram efeito condroprotetor, sem diferença estatística com relação aos diferentes pesos moleculares.
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- 2014
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43. Sildenafil citrate on retrobulbar and retinal circulation of rabbits
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Andréia Vitor Couto do Amaral, Germana Alegro da Silva, Ana Paula Araújo Costa, Cássia Maria Molinaro Coelho, Roberta Renzo, and José Luiz Laus
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coelhos ,citrato de sildenafil ,circulação retrobulbar ,circulação retiniana ,ultrassonografia ,angiografia fluoresceínica ,Agriculture ,Agriculture (General) ,S1-972 - Abstract
The effects of sildenafil on retrobulbar and retinal circulation were studied in 18 adult male, albino, homozygous rabbits, of the New Zealand White breed, randomly divided into 3 groups of 6 animals, for drug treatment at a dose of 3.5mg kg-1 every 24 hours, for 7, 15 and 30 days. Nine animals used for control were treated with saline solution at 0.9%. It was evaluated intraocular pressure (IOP), mean arterial pressure (MAP), ocular perfusion pressure (PPO), B-mode ultrasonography and fluorescein angiography before and at the end of treatments. A slight decrease in results of IOP, MAP and PPO after treatment with sildenafil was evident, however, there was no statistical significance. It was observed significant increased diameter of the ophthalmic artery after 7 and 30 days of treatment and decreased mean arterial pressure after 7, 15 and 30 days of treatment, with no statistical difference. On fluorescein angiography, it was observed that the arterial, arteriovenous and venous stages initiated more rapidly in animals after treatment, with significant difference on the arteriovenous stage at the 7th and 15th days. It was possible to admit that the sildenafil citrate improves blood circulation in the retina of rabbits, by increasing the speed of blood flow and decreasing the perfusion pressure.
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- 2014
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44. Comparative Study of the Use of Intra-articular and Systemic Meloxicam to Control Experimentally Induced Osteoarthritis in Rabbit Knees
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Valeria Trombini Vidotto, Rodrigo Tesser da Rocha, Caroline Lorraine de Paiva, Joao Ricardo Nardotto, Anderson Farias, and Sandro Alex Stefanes
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Osteoartrite ,Anti-inflamatorios ,Injecoes intra-articulares ,Joelho ,Coelhos ,Medicine ,Orthopedic surgery ,RD701-811 - Abstract
Objective: This study aimed to evaluate morphologic changes, as well as chondroprotective and intra-articular effects of meloxicam on joint repair in rabbits induced by experimental trochleoplasty, minimizing possible adverse side effects. Methods: Thirty-five rabbits were divided into four groups: the control group, which did not undergo surgery, and operated groups, which used different ways of administering the anti-inflammatory agent: systemic, 0.2 mg/kg; intra-articular, 0.5 mg/kg; positive group control, without meloxicam. Each operated group was divided according to the periods of 7 or 30 days evaluation after surgery. Results: Regarding macroscopic and histological evaluation of cartilage, after 30 days, most animals showed almost complete joint repair, the presence of few or no inflammatory cells; whereas part of the animals treated with meloxicam presented necrosis in the trochlear ridge and absence of inflammatory cells after 7 days. In positive control group, it was observed moderate inflammation and connective tissue proliferation. None of the animals in the operated groups showed irregularities 30 days after surgery. Conclusion: Either intra-articular or systemic, meloxicam revealed to be favorable to be used for joint repair and control of inflammatory reaction.
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- 2013
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45. Ramos colaterais do arco aórtico e suas principais ramificações em coelho da raça Nova Zelândia (Oryctolagus cuniculus)
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Fernanda de Souza, Andréia Zechin Bavaresco, and Rui Campos
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arco aórtico ,vascularização ,coelhos ,Agriculture ,Agriculture (General) ,S1-972 - Abstract
Neste trabalho, sistematizaram-se os ramos colaterais do arco aórtico e suas principais ramificações, utilizando 30 coelhos da raça Nova Zelândia. O sistema arterial foi preenchido com látex corado em vermelho através da aorta torácica no sentido contrário ao fluxo sanguíneo e fixado em uma solução aquosa de formaldeído a 20%. Os ramos colaterais do arco aórtico foram o tronco braquiocefálico e a artéria subclávia esquerda. O tronco braquiocefálico emitiu as artérias carótidas comuns esquerda e direita, continuando-se como artéria subclávia direita. Esta emitiu, de medial para lateral, as artérias: vertebral, tronco comum cervical superficial-profunda e tronco costocervical-torácica interna. Já a artéria subclávia esquerda emitiu as artérias: vertebral, intercostal suprema, torácica interna, escapular dorsal e tronco comum cervical superficial-profunda.
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- 2013
46. Placas ósseas confeccionadas a partir de diáfise cortical equina na osteossíntese femoral em coelhos
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Fernando Pinheiro Milori, Juliany Quitzan, Renato Silva de Souza, Silvana Maris Cirio, Peterson Triches Dornbusch, and Antônia Maria R. Binder do Prado
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Ortopedia ,osso cortical ,placa ,coelhos ,Veterinary medicine ,SF600-1100 - Abstract
A evolução tecnológica tem possibilitado o desenvolvimento e o aperfeiçoamento de novos materiais para implantes. Apesar dos fundamentais benefícios providos pelos dispositivos ortopédicos, complicações decorrentes de corrosão, degradação, infecção, além de outras podem ocorrer. O entendimento das características dos biomateriais é fundamental para a previsibilidade do seu comportamento in vivo, fornecendo subsídios para que o composto mais adequado seja escolhido na reconstrução do defeito ósseo. As placas de origem metálica são as mais utilizadas para o reparo de fraturas de ossos longos, sendo mecanicamente resistentes e biocompatíveis. No entanto, a necessidade de remoção e o enfraquecimento do osso são suas principais desvantagens. Neste trabalho, placas produzidas a partir de osso cortical equino foram empregadas experimentalmente em fêmur osteotomizado de coelhos (Grupo osso-GO), num estudo comparativo com placas de metal (Grupo metal-GM). A avaliação radiográfica foi realizada a cada 30 dias, durante 120 dias, momento em que foi então realizada análise histológica do material em estudo. Não houve diferença estatisticamente significante entre os dois grupos com relação à morfometria do calo ósseo e consolidação óssea em todos os momentos avaliados, sendo que ambas as placas permitiram a consolidação em todos os animais. Entretanto, observou-se que o calo ósseo foi menor no GO, em relação ao GM, em todos os momentos do estudo. Por outro lado, a maior parte dos animais do GO apresentou consolidação completa da fratura aos 90 dias, enquanto que no GM isto ocorreu aos 60 dias. Não foram evidenciadas células do tipo corpo estranho na histopatologia dos animais do GO, mas maior quantidade de tecido fibroso foi identificada, envolvendo este biomaterial. A placa confeccionada com osso equino representa uma alternativa de baixo custo e muito viável, uma vez que permitiu estabilização adequada para consolidação óssea de fratura de fêmur em coelhos. Neste estudo, a menor formação de calo periosteal, associada a um tempo superior para consolidação em GO sugerem maior estabilidade da fratura onde a placa de osso foi utilizada.
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- 2013
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47. Efeitos benéficos do óleo de coco (Cocos nucifera) em marcadores hematobioquímicos e histopatológicos em coelhos intoxicados com CCL4
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B. Ahmad, W. Khan, T. U. Haq, S. Ahmad, M. Zahoor, A. Alotaibi, and R. Ullah
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Cocos ,rabbits ,antioxidant ,alternative of silymarine ,antioxidante ,food and beverages ,hepatoprotective ,óleo de coco ,coelhos ,Coconut Oil ,Animals ,Rabbits ,Chemical and Drug Induced Liver Injury ,General Agricultural and Biological Sciences ,hepatoprotetor ,Carbon Tetrachloride ,alternativa de silimarina ,coconut oil - Abstract
The study was designed to investigate the effect of Coconut Oil on the levels of some liver and hematological parameters in carbon tetrachloride intoxicated rabbits. Also the antioxidant capacity of Coconut Oil for various concentrations was assessed on the basis of percent scavenging of (DPPH) free radical. Experimental animals were divided into five groups, eight rabbits in each group. These were: group A (Normal control), group B (Toxic control), group C (Standard control), group D (Treated with Coconut Oil 50 mL/kg body weight after CCl4 intoxication), group E (Treated with Coconut Oil 200 mL/kg body weight after CCl4 intoxication). The effects observed were compared with a standard hepatoprotective drug silymarine (50 mL/kg body weight). The Coconut Oil (200 mL/kg body weight) significantly (P
- Published
- 2022
48. THE ROUND LIGAMENT IN DEVELOPMENTAL HIP DYSPLASIA: ARE ITS MECHANICAL AND HISTOLOGICAL PROPERTIES PRESERVED?
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ALEXANDRE ZUCCON, HAMILTON DA ROSA PEREIRA, SÉRGIO ALEXANDRE ALCÂNTARA DOS SANTOS, SÉRGIO LUÍS FELISBINO, LUÍS ANTÔNIO JUSTULIN JUNIOR, DANIELE CRISTINA CATANEO, Universidade Estadual Paulista (UNESP), and Associação de Assistência à Criança Deficiente (AACD)
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Orthopedic surgery ,Hip dislocation ,Rehabilitation ,Physical Therapy, Sports Therapy and Rehabilitation ,Luxação do quadril ,Round ligaments ,Coelhos ,Models, animal ,Ligamentos redondos ,Models ,Medicine ,Colágeno ,animal ,Orthopedics and Sports Medicine ,Collagen ,Rabbits ,RD701-811 ,Modelos animais - Abstract
Introduction During open surgical dislocated hip reduction, several anatomical structures, such as the round ligament, are approached. However, there is controversy over both the possibility of preserving the ligament and its functional importance. Materials and Methods This experimental study used skeletally immature rabbits as a model for congenital hip dislocation. Thirty-six rabbits comprised the sample that was submitted to the round ligament analysis. The sample was stratified for analysis (biomechanics, zymography, histology, and immunohistochemistry). Statistical analysis compared the unstable side to the control side of each rabbit. Results Biomechanical assays showed that the mean maximal strength of the round ligament on the unstable side was similar to that of the control side (p = 0.594), which was also the case with maximum deformation (p = 0.328). Histologically, there was a statistically significant increase in cellularity on the unstable side (p
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- 2022
49. Effects of topical and subconjunctival use of bevacizumab on corneal neovascularization in rabbits' eyes.
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APARECIDO LOPES, GERSON JORGE, BARBANTE CASELLA, ANTONIO MARCELO, PAULA OGUIDO, ANA, and MATSUO, TIEMI
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CORNEA ,BEVACIZUMAB ,NEOVASCULARIZATION ,NEOVASCULARIZATION inhibitors ,INJECTIONS ,LABORATORY rabbits - Abstract
Copyright of Arquivos Brasileiros de Oftalmologia is the property of Arquivos Brasileiros de Oftalmologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2017
- Full Text
- View/download PDF
50. Ressonância magnética na avaliação de enxerto osteocondral autógeno na cartilagem articular de coelhos.
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Kawamoto, Fernando Y. K., Muzzi, Leonardo A. L., Liria, Bruno O. A. G., Camassa, José A. A., Moreira, Stella H., Rossignoli, Pedro P., and Muzzi, Ruthnéa A. L.
- Abstract
Copyright of Pesquisa Veterinaria Brasileira is the property of Colegio Brasileiro de Patologia Animal - CBPA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2017
- Full Text
- View/download PDF
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