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201 results on '"Conway, C M"'

7. Post-Operative Hypoxaemia

Author

Mountford, Lawrence, Conway, C. M., Payne, J. P., and Harvey, R. E. M. Coke

Published
1963

9. Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain

Author

Kostich, W., primary, Hamman, B. D., additional, Li, Y.-W., additional, Naidu, S., additional, Dandapani, K., additional, Feng, J., additional, Easton, A., additional, Bourin, C., additional, Baker, K., additional, Allen, J., additional, Savelieva, K., additional, Louis, J. V., additional, Dokania, M., additional, Elavazhagan, S., additional, Vattikundala, P., additional, Sharma, V., additional, Das, M. L., additional, Shankar, G., additional, Kumar, A., additional, Holenarsipur, V. K., additional, Gulianello, M., additional, Molski, T., additional, Brown, J. M., additional, Lewis, M., additional, Huang, Y., additional, Lu, Y., additional, Pieschl, R., additional, OMalley, K., additional, Lippy, J., additional, Nouraldeen, A., additional, Lanthorn, T. H., additional, Ye, G., additional, Wilson, A., additional, Balakrishnan, A., additional, Denton, R., additional, Grace, J. E., additional, Lentz, K. A., additional, Santone, K. S., additional, Bi, Y., additional, Main, A., additional, Swaffield, J., additional, Carson, K., additional, Mandlekar, S., additional, Vikramadithyan, R. K., additional, Nara, S. J., additional, Dzierba, C., additional, Bronson, J., additional, Macor, J. E., additional, Zaczek, R., additional, Westphal, R., additional, Kiss, L., additional, Bristow, L., additional, Conway, C. M., additional, Zambrowicz, B., additional, and Albright, C. F., additional

Published
2016
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19. Persistence of external signs in Pacific herring Clupea pallasii Valenciennes with ichthyophoniasis.

Author

Hart, L M, Conway, C M, Elliott, D G, and Hershberger, P K

Subjects
*ICHTHYOSPORIDIUM hoferi, *PACIFIC herring, *INFECTIONS in fish, *FISH mortality, *HISTOPATHOLOGY
Abstract

The progression of external signs of Ichthyophonus infection in Pacific herring Clupea pallasii Valenciennes was highly variable and asynchronous after intraperitoneal injection with pure parasite preparations; however, external signs generally persisted through the end of the study (429 days post-exposure). Observed signs included papules, erosions and ulcers. The prevalence of external signs plateaued 35 days post-exposure and persisted in 73-79% of exposed individuals through the end of the first experiment (147 days post-exposure). Among a second group of infected herring, external signs completely resolved in only 10% of the fish after 429 days. The onset of mortality preceded the appearance of external signs. Histological examination of infected skin and skeletal muscle tissues indicated an apparent affinity of the parasite for host red muscle. Host responses consisted primarily of granulomatous inflammation, fibrosis and necrosis in the skeletal muscle and other tissues. The persistence and asynchrony of external signs and host response indicated that they were neither a precursor to host mortality nor did they provide reliable metrics for hindcasting on the date of exposure. However, the long-term persistence of clinical signs in Pacific herring may be useful in ascertaining the population-level impacts of ichthyophoniasis in regularly observed populations. [ABSTRACT FROM AUTHOR]

Published
2016
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21. Detection of Ichthyophonus by chromogenic in situ hybridization.

Author

Conway, C M, Purcell, M K, Elliott, D G, and Hershberger, P K

Subjects
*ICHTHYOSPORIDIUM hoferi, *ICHTHYOSPORIDIUM, *IN situ hybridization, *NUCLEIC acid hybridization, *PROTISTA
Abstract

The article discusses the detection of Ichthyophonus by chromogenic in situ hybridization. It says that Ichthyophonus (I.) hoferi is a protistan parasite in the class Mesomycetozoea that infects a range of marine and freshwater fish. It adds that only two species, I. hoferi and I. irregularis, are recognized within the genus, at present.

Published
2015
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22. Infecting Pacific Herring with Ichthyophonussp. in the Laboratory

Author

Hershberger, P. K., Hart, L. M., MacKenzie, A. H., Yanney, M. L., Conway, C. M., and Elliott, D. G.

Abstract

The protistan parasite Ichthyophonussp. occurs in coastal populations of Pacific Herring Clupea pallasiithroughout the northeast Pacific region, but the route(s) by which these planktivorous fish become infected is unknown. Several methods for establishing Ichthyophonusinfections in laboratory challenges were examined. Infections were most effectively established after intraperitoneal (IP) injections with suspended parasite isolates from culture or after repeated feedings with infected fish tissues. Among groups that were offered the infected tissues, infection prevalence was greater after multiple feedings (65%) than after a single feeding (5%). Additionally, among groups that were exposed to parasite suspensions prepared from culture isolates, infection prevalence was greater after exposure by IP injection (74%) than after exposure via gastric intubation (12%); the flushing of parasite suspensions over the gills did not lead to infections in any of the experimental fish. Although the consumption of infected fish tissues is unlikely to be the primary route of Ichthyophonussp. transmission in wild populations of Pacific Herring, this route may contribute to abnormally high infection prevalence in areas where juveniles have access to infected offal. Received June 25, 2015; accepted September 12, 2015

Published
2015
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29. Stereoselective Synthesis of New Conformationally Restricted Analogues of a Potent CGRP Receptor Antagonist

Author

Zuev, D., Michne, J. A., Huang, H., Beno, B. R., Wu, D., Gao, Q., Torrente, J. R., Xu, C., Conway, C. M., Macor, J. E., and Dubowchik, G. M.

Abstract

A stereocontrolled racemic synthesis of conformationally restricted analogues 2a and 2b of a potent CGRP receptor antagonist 1 by novel functionalization of 2-substituted octahydropyrido[1,2-a]pyrazin-6-ones is described. The new diastereoselective LDA-promoted α-nitration of intermediate lactams established the required trans-configuration in the desired products.

Published
2005

30. An analogue device for measuring the pre-ejection period (PEP).

Author

BLACKBURN, J. P., CONWAY, C. M., LEIGH, J. M., LINDOP, M. J., REITAN, J. A., and ROBBINS, R.

Abstract

A special purpose analogue computer for beat by beat determination of the pre-ejection period of cardiac systole is described. [ABSTRACT FROM PUBLISHER]

Published
1972

36. Geological Features of Southwestern North America

Author

Silver, L. T., Anderson, T. H., Conway, C. M., Murray, J. D., and Powell, R. E.

Abstract

The SKYLAB 4 crewmen conducted visual observations of seven designated geological target areas and other targets of opportunity in parts of southwestern United States and northwestern Mexico. The experiments were designed to determine how effectively geologic features could be observed from orbit and what research information could be obtained from the observations when supported by ground studies. For the limited preparation they received, the crewmen demonstrated exceptional observational ability and produced outstanding photographic studies. They also formulated cogent opinions on how to improve future observational and photo documentation techniques. Significant research contributions to ongoing field investigations were obtained from the photographs and observations. These contributions were integrated into other aspects of the ground investigations to (1) identify and evaluate zones of major faulting in southeastern California, Baja California, and northwestern Sonora; (2) develop a new key to the regional stratigraphy of the prebatholithic rocks of northern Baja California; (3) discover the most southwesterly known occurrence of Precambrian crystalline rocks in North America; (4) discover a previously unmapped section of Mesozoic (?) volcanic rocks in southeastern California; and (5) contribute important overview perspectives to many regional geologic problems. The experimental data and the demonstrated crew capabilities justify planning future geology visual observation experiments for manned Earth-orbiting programs such as the Space Shuttle. Both professional scientist-observers and astronaut-observers can make contributions if properly prepared and equipped. The experiments should be closely coordinated with active surface research investigations. The emphasis should be on selecting important problems and objectives and integrating orbital observations and ground studies, not on prospecting for isolated spectacular discoveries.

Published
1977

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