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3. FRI-070-YI Prevalence of dysgeusia in patients with advanced chronic liver disease, relationship with the liver-disease progression status, and impact on malnutrition-sarcopenia-frailty

Author

Dallio, Marcello, primary, Romeo, Mario, additional, Cipullo, Marina, additional, Coppola, Annachiara, additional, Mammone, Simone, additional, Zagaria, Giuseppe, additional, Iadanza, Giorgia, additional, Napolitano, Carmine, additional, Olivieri, Simone, additional, Maria Vitale, Luigi, additional, and Federico, Alessandro, additional

Published
2024
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7. Hericium erinaceus, in combination with natural flavonoid/alkaloid and B3/B8 vitamins, can improve inflammatory burden in Inflammatory bowel diseases tissue: an ex vivo study

Author

Gravina, Antonietta Gerarda, primary, Pellegrino, Raffaele, additional, Palladino, Giovanna, additional, Coppola, Annachiara, additional, Brandimarte, Giovanni, additional, Tuccillo, Concetta, additional, Ciardiello, Fortunato, additional, Romano, Marco, additional, and Federico, Alessandro, additional

Published
2023
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10. Hericium erinaceus, in combination with natural flavonoid/alkaloid and B3/B8 vitamins, can improve inflammatory burden in Inflammatory bowel diseases tissue: an ex vivo study.

Author

Gravina, Antonietta Gerarda, Pellegrino, Raffaele, Palladino, Giovanna, Coppola, Annachiara, Brandimarte, Giovanni, Tuccillo, Concetta, Ciardiello, Fortunato, Romano, Marco, and Federico, Alessandro

Subjects
INFLAMMATORY bowel diseases, HERICIUM erinaceus, ALKALOIDS, FLAVONOIDS, GENE expression
Abstract

Hericium erinaceus, berberine, and quercetin are effective in experimental colitis. It is unknown whether they can ameliorate inflammatory bowel diseases in humans. This ex vivo study aimed to evaluate the anti-inflammatory potential of a nutraceutical compound of HBQ-Complex® (H. erinaceus, berberine, and quercetin), biotin, and niacin in inflammatory bowel disease patients. Tissue specimens were obtained either from Normal-Appearing Mucosa (NAM) or from Inflamed Mucosa (IM) in 20 patients with inflammatory bowel disease. mRNA and protein expression of COX-2, IL-10, and TNF-a were determined in NAM and IM biopsy samples (T0). IM samples were then incubated in HBQ-Complex® (with the addition of niacin and biotin), and COX-2, IL-10, and TNF-#945; with this compound resulted in a progressive decrease in gene and protein COX-2 and TNF-a expression at T1/T2 in the IM. IL-10 showed an opposite trend, with a progressive increase of mRNA and protein expression over the same time window. HBQ-Complex® (with the addition of niacin and biotin) decreased the expression of proinflammatory cytokines at the mRNA and protein levels in IBD tissue. On the contrary, mRNA and protein expression of the anti-inflammatory cytokine IL-10 showed a progressive increase. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Sponge Whirl-Pak Sampling Method and Droplet Digital RT-PCR Assay for Monitoring of SARS-CoV-2 on Surfaces in Public and Working Environments

Author

Cardinale, Davide, primary, Tafuro, Maria, additional, Mancusi, Andrea, additional, Girardi, Santa, additional, Capuano, Federico, additional, Proroga, Yolande Thérèse Rose, additional, Corrado, Federica, additional, D’Auria, Jacopo Luigi, additional, Coppola, Annachiara, additional, Rofrano, Giuseppe, additional, Volzone, Palmiero, additional, Galdi, Pio, additional, De Vita, Sabato, additional, Gallo, Alfonso, additional, Suffredini, Elisabetta, additional, Pierri, Biancamaria, additional, Cerino, Pellegrino, additional, and Morgante, Maria, additional

Published
2022
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12. Assessment of Saliva Specimens' Reliability for COVID-19 Surveillance

Author

Pierri, Biancamaria, primary, Tafuro, Maria, additional, Cuomo, Maria Concetta, additional, Concilio, Denise Di, additional, Vassallo, Lucia, additional, Pierri, Andrea, additional, Ferro, Amedeo, additional, Rofrano, Giuseppe, additional, Gallo, Alfonso, additional, Stasio, Antonio Di, additional, Mancusi, Andrea, additional, Galdi, Lydia, additional, Coppola, Annachiara, additional, Buonerba, Carlo, additional, Atripaldi, Luigi, additional, and Cerino, Pellegrino, additional

Published
2022
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13. Durability of Humoral Immune Responses to SARS-CoV-2 in Citizens of Ariano Irpino (Campania, Italy): A Longitudinal Observational Study With an 11.5-Month Follow-Up

Author

Coppola, Annachiara, primary, Buonerba, Carlo, additional, Cardinale, Davide, additional, Lo Conte, Gabriella, additional, Sansone, Donato, additional, Rofrano, Giuseppe, additional, De Vita, Sabato, additional, Morgante, Maria, additional, Triassi, Maria, additional, Atripaldi, Luigi, additional, Brambilla, Gianfranco, additional, Sabatino, Rocco, additional, Pierri, Andrea, additional, Pacella, Daniela, additional, Pizzolante, Antonio, additional, Pierri, Biancamaria, additional, Ferrucci, Veronica, additional, Zollo, Massimo, additional, Capasso, Mario, additional, Stringhini, Silvia, additional, Ascierto, Paolo Antonio, additional, Roperto, Sante, additional, and Cerino, Pellegrino, additional

Published
2021
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14. An observational study of a cohort of citizens receiving the AZD1222 vaccine against SARS-CoV-2

Author

Cerino, Pellegrino, primary, Coppola, Annachiara, additional, Pierri, Biancamaria, additional, Volzone, Palmiero, additional, Bruzzese, Dario, additional, Pierri, Andrea, additional, Ferro, Amedeo, additional, Schiavi, Daniela, additional, Coppola, Antonio, additional, Miniero, Stefano, additional, Atripaldi, Luigi, additional, Pirozzi, Caterina, additional, Rusciano, Pasquale, additional, Macri, Alessandra, additional, Boenzi, Rita, additional, Sale, Silvia, additional, Brambilla, Gianfranco, additional, and Buonerba, Carlo, additional

Published
2021
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15. No detection of SARS-CoV-2 in animals exposed to infected keepers: results of a COVID-19 surveillance program

Author

Cerino, Pellegrino, primary, Buonerba, Carlo, additional, Brambilla, Gianfranco, additional, Atripaldi, Luigi, additional, Tafuro, Maria, additional, Concilio, Denise Di, additional, Vassallo, Lucia, additional, Conte, Gabriella Lo, additional, Cuomo, Maria Concetta, additional, Maiello, Ivana, additional, D'Auria, Jacopo, additional, Cardinale, Davide, additional, Viscardi, Maurizio, additional, Rofrano, Giuseppe, additional, Gallo, Alfonso, additional, Brusco, Pasquale, additional, Pizzolante, Antonio, additional, Cicalese, Vittorio, additional, Galdi, Pio, additional, Galdi, Lydia, additional, Vita, Sabato De, additional, Volzone, Palmiero, additional, Vuolo, Gabriele Di, additional, Coppola, Annachiara, additional, Pierri, Biancamaria, additional, and Fusco, Giovanna, additional

Published
2021
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16. Seroprevalence of SARS-CoV-2 Assessed by Four Chemiluminescence Immunoassays and One Immunocromatography Test for SARS-Cov-2

Author

Cerino, Pellegrino, primary, Gallo, Alfonso, additional, Pierri, Biancamaria, additional, Buonerba, Carlo, additional, Di Concilio, Denise, additional, Cuomo, Maria Concetta, additional, Vassallo, Lucia, additional, Lo Conte, Gabriella, additional, Coppola, Annachiara, additional, Pizzolante, Antonio, additional, Boccia, Giovanni, additional, Ferrucci, Veronica, additional, Atripaldi, Luigi, additional, Triassi, Maria, additional, Pacella, Daniela, additional, Cennamo, Michele, additional, Romano, Paolo, additional, Sorbo, Teresa Maria, additional, Furno, Alessandro, additional, Catapano, Oriana, additional, Contina, Aldo, additional, Perruolo, Giuseppe, additional, D'Amora, Maurizio, additional, Terracciano, Daniela, additional, and Portella, Giuseppe, additional

Published
2021
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17. Seroprevalence of SARS-CoV-2-specific antibodies in the town of Ariano Irpino (Avellino, Campania, Italy): a population-based study

Author

Cerino, Pellegrino, primary, Coppola, Annachiara, additional, Volzone, Palmiero, additional, Pizzolante, Antonio, additional, Pierri, Biancamaria, additional, Atripaldi, Luigi, additional, Zollo, Massimo, additional, Capasso, Mario, additional, Ascierto, Paolo Antonio, additional, Triassi, Maria, additional, Brambilla, Gianfranco, additional, Perrella, Alessandro, additional, Bruzzese, Dario, additional, and Buonerba, Carlo, additional

Published
2021
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19. Seroprevalence of SARS-CoV-2 Assessed by Four Chemiluminescence Immunoassays and One Immunocromatography Test for SARS-Cov-2

Author

Pellegrino Cerino, Alfonso Gallo, Biancamaria Pierri, Carlo Buonerba, Denise Di Concilio, Maria Concetta Cuomo, Lucia Vassallo, Gabriella Lo Conte, Annachiara Coppola, Antonio Pizzolante, Giovanni Boccia, Veronica Ferrucci, Luigi Atripaldi, Maria Triassi, Daniela Pacella, Michele Cennamo, Paolo Romano, Teresa Maria Sorbo, Alessandro Furno, Oriana Catapano, Aldo Contina, Giuseppe Perruolo, Maurizio D'Amora, Daniela Terracciano, Giuseppe Portella, Cerino, Pellegrino, Gallo, Alfonso, Pierri, Biancamaria, Buonerba, Carlo, Di Concilio, Denise, Cuomo, Maria Concetta, Vassallo, Lucia, Lo Conte, Gabriella, Coppola, Annachiara, Pizzolante, Antonio, Boccia, Giovanni, Ferrucci, Veronica, Atripaldi, Luigi, Triassi, Maria, Pacella, Daniela, Cennamo, Michele, Romano, Paolo, Sorbo, Teresa Maria, Furno, Alessandro, Catapano, Oriana, Contina, Aldo, Perruolo, Giuseppe, D'Amora, Maurizio, Terracciano, Daniela, and Portella, Giuseppe

Subjects
Luminescence, Context (language use), Sensitivity and Specificity, Serology, 03 medical and health sciences, 0302 clinical medicine, Cohen's kappa, rapid test, Seroepidemiologic Studies, medicine, Seroprevalence, Humans, 030212 general & internal medicine, rapid tests, Original Research, 030304 developmental biology, Immunoassay, 0303 health sciences, medicine.diagnostic_test, biology, seroprevalence, business.industry, SARS-CoV-2, Public Health, Environmental and Occupational Health, Seroprevalence of SARS-CoV-2, COVID-19, Virology, immunoassays, serological test, Immunoglobulin M, Italy, biology.protein, Public Health, Antibody, Public aspects of medicine, RA1-1270, business
Abstract

The onset of the new SARS-CoV-2 coronavirus encouraged the development of new serologic tests that could be additional and complementary to real-time RT-PCR-based assays. In such a context, the study of performances of available tests is urgently needed, as their use has just been initiated for seroprevalence assessment. The aim of this study was to compare four chemiluminescence immunoassays and one immunochromatography test for SARS-Cov-2 antibodies for the evaluation of the degree of diffusion of SARS-CoV-2 infection in Salerno Province (Campania Region, Italy). A total of 3,185 specimens from citizens were tested for anti-SARS-CoV-2 antibodies as part of a screening program. Four automated immunoassays (Abbott and Liaison SARS-CoV-2 CLIA IgG and Roche and Siemens SARS-CoV-2 CLIA IgM/IgG/IgA assays) and one lateral flow immunoassay (LFIA Technogenetics IgG–IgM COVID-19) were used. Seroprevalence in the entire cohort was 2.41, 2.10, 1.82, and 1.85% according to the Liaison IgG, Abbott IgG, Siemens, and Roche total Ig tests, respectively. When we explored the agreement among the rapid tests and the serologic assays, we reported good agreement for Abbott, Siemens, and Roche (Cohen's Kappa coefficient 0.69, 0.67, and 0.67, respectively), whereas we found moderate agreement for Liaison (Cohen's kappa coefficient 0.58). Our study showed that Abbott and Liaison SARS-CoV-2 CLIA IgG, Roche and Siemens SARS-CoV-2 CLIA IgM/IgG/IgA assays, and LFIA Technogenetics IgG-IgM COVID-19 have good agreement in seroprevalence assessment. In addition, our findings indicate that the prevalence of IgG and total Ig antibodies against SARS-CoV-2 at the time of the study was as low as around 3%, likely explaining the amplitude of the current second wave.

Published
2021
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20. Modulation of the cytokine profile in Caco-2 cells by faecal lactobacilli and bifidobacteria from individuals with distinct dietary habits

Author

Diomira Luongo, Annachiara Coppola, A. Sorrentino, Raffaella Di Cagno, Ilario Ferrocino, Luca Simone Cocolin, Erasmo Neviani, Paolo Bergamo, Lucia Treppiccione, Silvia Turroni, Mauro Rossi, Luongo, Diomira, Coppola, Annachiara, Treppiccione, Lucia, Bergamo, Paolo, Sorrentino, Alida, Ferrocino, Ilario, Turroni, Silvia, Neviani, Erasmo, Di Cagno, Raffaella, Cocolin, Luca, and Rossi, Mauro

Subjects
0301 basic medicine, Adult, Male, Thymic stromal lymphopoietin, Adolescent, Enterocyte, medicine.medical_treatment, Immunology, Biochemistry, Microbiology, 03 medical and health sciences, Food Preferences, Immune system, Thymic Stromal Lymphopoietin, Immunity, Lactobacillus, medicine, Immunology and Allergy, Humans, Molecular Biology, Diet Enterocyte Immunity Microbiota, biology, Microbiota, Interleukin-8, Hematology, Dendritic cell, Feeding Behavior, Middle Aged, biology.organism_classification, Diet, 030104 developmental biology, medicine.anatomical_structure, Cytokine, Caco-2, Cytokines, Tetradecanoylphorbol Acetate, Female, Bifidobacterium, Caco-2 Cells
Abstract

Enterocytes are actively involved in the defense against pathogens and they limit penetration of commensal microbes into tissues. They also have an important role in gut immunity as enterocytes confer mucosal dendritic cell specialisation. On the other hand, the microbiota is directly involved in the development and modulation of the intestinal immune system. Particularly, lactobacilli and bifidobacteria play a primary role in shaping the immune response. We further explored this issue by evaluating whether functional differences in Caco-2 cells could characterise faecal populations of lactobacilli (155 samples) and bifidobacteria (110 samples) isolated from three dietary cohorts (omnivores, ovo-lacto-vegetarians and vegans) recruited at four Italian centres (Turin, Parma, Bologna and Bari). According to our findings, tested bacteria were unable to modulate expression of IL-8, IL-10, TGF-β or thymic stromal lymphopoietin (TSLP) cytokines in unstimulated Caco-2 cells. Conversely, in phorbol 12-myristate 13-acetate and ionomycin (PMA/Io) stimulated Caco-2 cells, lactobacilli from the omnivorous group and all bifidobacteria significantly down-regulated IL-8. Notably, both genera also lowered the TSLP expression in stimulated Caco-2 cells, regardless of the diet regimen. By further examining these data on the basis of geographical origin, we found that lactobacilli from the vegetarian group recruited in Bari, significantly up-regulated this cytokine. In conclusion, we highlighted a peculiar immune-modulatory activity profile for lactobacilli on enterocytes undergoing a stimulatory signal, which was associated with a specific dietary habit. Furthermore, the geographical area had a significant impact on the inflammatory potential of members of the Lactobacillus genus.

Published
2017

21. Hericium erinaceus , in combination with natural flavonoid/alkaloid and B 3 /B 8 vitamins, can improve inflammatory burden in Inflammatory bowel diseases tissue: an ex vivo study.

Author

Gravina AG, Pellegrino R, Palladino G, Coppola A, Brandimarte G, Tuccillo C, Ciardiello F, Romano M, and Federico A

Subjects
Humans, Interleukin-10 genetics, Interleukin-10 metabolism, Tumor Necrosis Factor-alpha metabolism, Vitamins metabolism, Flavonoids, Biotin metabolism, Quercetin metabolism, Cyclooxygenase 2 genetics, Cyclooxygenase 2 metabolism, Intestinal Mucosa metabolism, Cytokines metabolism, RNA, Messenger metabolism, Niacin metabolism, Berberine, Inflammatory Bowel Diseases metabolism, Antineoplastic Agents
Abstract

Hericium erinaceus , berberine, and quercetin are effective in experimental colitis. It is unknown whether they can ameliorate inflammatory bowel diseases in humans. This ex vivo study aimed to evaluate the anti-inflammatory potential of a nutraceutical compound of HBQ-Complex ® ( H. erinaceus , berberine, and quercetin), biotin, and niacin in inflammatory bowel disease patients. Tissue specimens were obtained either from Normal-Appearing Mucosa (NAM) or from Inflamed Mucosa (IM) in 20 patients with inflammatory bowel disease. mRNA and protein expression of COX-2, IL-10, and TNF-α were determined in NAM and IM biopsy samples (T0). IM samples were then incubated in HBQ-Complex ® (with the addition of niacin and biotin), and COX-2, IL-10, and TNF-α tissue levels were evaluated at 120 minutes (T1) and 180 minutes (T2). Incubation with this compound resulted in a progressive decrease in gene and protein COX-2 and TNF-α expression at T1/T2 in the IM. IL-10 showed an opposite trend, with a progressive increase of mRNA and protein expression over the same time window. HBQ-Complex ® (with the addition of niacin and biotin) decreased the expression of proinflammatory cytokines at the mRNA and protein levels in IBD tissue. On the contrary, mRNA and protein expression of the anti-inflammatory cytokine IL-10 showed a progressive increase., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Gravina, Pellegrino, Palladino, Coppola, Brandimarte, Tuccillo, Ciardiello, Romano and Federico.)

Published
2023
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22. Population-based human biomonitoring in the 'Land of Fires' area: innovations in study design and procedures.

Author

Pierri B, Buonerba C, Coppola A, Pizzolante A, Stasio AD, and Cerino P

Abstract

Competing Interests: Financial & competing interests disclosure The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. No writing assistance was utilized in the production of this manuscript.

Published
2020
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