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178 results on '"Cougnard‐Grégoire, Audrey"'

3. Association of Systemic Medication Use with Glaucoma and Intraocular Pressure: The European Eye Epidemiology Consortium

Author

Vergroesen, Joëlle E., Schuster, Alexander K., Stuart, Kelsey V., Asefa, Nigus G., Cougnard-Grégoire, Audrey, Delcourt, Cécile, Schweitzer, Cédric, Barreto, Patrícia, Coimbra, Rita, Foster, Paul J., Luben, Robert N., Pfeiffer, Norbert, Stingl, Julia V., Kirsten, Toralf, Rauscher, Franziska G., Wirkner, Kerstin, Jansonius, Nomdo M., Arnould, Louis, Creuzot-Garcher, Catherine P., Stricker, Bruno H., Keskini, Christina, Topouzis, Fotis, Bertelsen, Geir, Eggen, Anne E., Bikbov, Mukharram M., Jonas, Jost B., Klaver, Caroline C.W., Ramdas, Wishal D., and Khawaja, Anthony P.

Published
2023
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8. Physical Activity, Incidence, and Progression of Age-Related Macular Degeneration: A Multicohort Study

Author

Mauschitz, Matthias M., Schmitz, Marie-Therese, Verzijden, Timo, Schmid, Matthias, Thee, Eric F., Colijn, Johanna M., Delcourt, Cécile, Cougnard-Grégoire, Audrey, Merle, Bénédicte M.J., Korobelnik, Jean-François, Gopinath, Bamini, Mitchell, Paul, Elbaz, Hisham, Schuster, Alexander K., Wild, Philipp S., Brandl, Caroline, Stark, Klaus J., Heid, Iris M., Günther, Felix, Peters, Annette, Klaver, Caroline C.W., and Finger, Robert P.

Published
2022
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9. Development of a Genotype Assay for Age-Related Macular Degeneration: The EYE-RISK Consortium

Author

Ajana, Soufiane, Cougnard-Grégoire, Audrey, Delcourt, Cécile, Merle, Bénédicte M.J., Arango-Gonzalez, Blanca, Dammeier, Sascha, Diether, Sigrid, Honisch, Sabina, Kilger, Ellen, Ueffing, Marius, Endermann, Tanja, Zumbansen, Markus, Badura, Franz, De la Cerda, Berta, Biarnés, Marc, Borrell, Anna, Ferraro, Lucia L., Garcia, Míriam, Monés, Jordi, Rodríguez, Eduardo, Colijn, Johanna M., Ikram, A., Klaver, Caroline C.W., Meester-Smoor, Magda, Verzijden, Timo, Vingerling, Johannes, den Hollander, Anneke I., Heesterbeek, Thomas J., Kersten, Eveline, de Jong, Eiko K., Acar, I. Erkin, de Breuk, Anita, Emri, Eszter, Lengyel, Imre, Langen, Hanno, Nogoceke, Everson, Peto, Tunde, Luthert, Phil, Pool, Frances M., Acar, Ilhan E., Schijvenaars, Mascha M.V.A.P., Haer-Wigman, Lonneke, Bakker, Bjorn, de Jong, Sarah, Meester-Smoor, Magda A., Missotten, Tom O.A.R., Pauleikhoff, Daniel, Hense, Hans W., Silva, Rufino, Nunes, Sandrina, Melo, Joana B., Fauser, Sascha, Hoyng, Carel B., and Coenen, Marieke J.H.

Published
2021
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11. Predicting Progression to Advanced Age-Related Macular Degeneration from Clinical, Genetic, and Lifestyle Factors Using Machine Learning

Author

Acar, Erkin I., Arango-Gonzalez, Blanca, Armento, Angela, Badura, Franz, Bhatia, Vaibhav, Bhattacharya, Shomi S., Biarnés, Marc, Borrell, Anna, Calado, Sofia M., Dammeier, Sascha, de Breuk, Anita, De la Cerda, Berta, den Hollander, Anneke I., Diaz-Corrales, Francisco J., Diether, Sigrid, Emri, Eszter, Endermann, Tanja, Ferraro, Lucia L., Garcia, Míriam, Heesterbeek, Thomas J., Honisch, Sabina, Hoyng, Carel B., Kilger, Ellen, Kortvely, Elod, Lastrucci, Claire, Langen, Hanno, Lengyel, Imre, Luthert, Phil, Monés, Jordi, Nogoceke, Everson, Peto, Tunde, Pool, Frances M., Rodriguez-Bocanegra, Eduardo, Serrano, Luis, Sousa, Jose, Thee, Eric, Ueffing, Marius, Ulrich Bartz-Schmidt, Karl U., Zumbansen, Markus, Ajana, Soufiane, Cougnard-Grégoire, Audrey, Colijn, Johanna M., Merle, Bénédicte M.J., Verzijden, Timo, de Jong, Paulus T.V.M., Hofman, Albert, Vingerling, Johannes R., Hejblum, Boris P., Korobelnik, Jean-François, Meester-Smoor, Magda A., Jacqmin-Gadda, Hélène, Klaver, Caroline C.W., and Delcourt, Cécile

Published
2021
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12. Associations of drusen location with risk factors and incidence of late age‐related macular degeneration in the Alienor study.

Author

Sénéclauze, Arnaud, Le Goff, Mélanie, Cougnard‐Grégoire, Audrey, Korobelnik, Jean‐François, Rougier, Marie‐Bénédicte, Delyfer, Marie‐Noëlle, Delcourt, Cécile, and Gattoussi, Sarra

Subjects
MACULAR degeneration, CATARACT surgery, BLOOD lipids, MEDICAL prescriptions
Abstract

Purpose: To test the hypothesis that central drusen location is strongly linked with known Age‐related Macular Degeneration (AMD) risk factors and risk of incident late AMD. Methods: The Alienor study is a prospective population‐based cohort study of residents of Bordeaux, France, followed from 2009 to 2017. On retinal photographs, we defined central drusen as at least one soft drusen (>63 μm) within 500 μm from fovea and pericentral drusen as at least one drusen 500–3000 μm from fovea, in the absence of any central drusen. Late AMD (atrophic and/or neovascular) was diagnosed using multimodal imaging. In total, 481 eyes were included in the analysis: 160 central and 321 pericentral. We investigated associations with systemic (age, sex, smoking, medical prescriptions, plasma concentrations of lipids and nutrients, UV exposure, blood pressure), ocular (retinal thickness, cataract extraction) and genetic risk scores (GRS). Results: In multivariate logistic regression central drusen were associated with smoking (OR, 2.95 for smoking more than 20 pack‐years, p = 0.02), HDL‐cholesterol (OR, 1.57 for 1 standard deviation (SD) increase, p = 0.0048), pulse pressure (OR, 0.77 for 1 SD increase, p = 0.04), Age‐Related Maculopathy Susceptibility 2 (ARMS2) GRS (OR, 1.42; 95% CI, 1.11–1.83) and complement GRS (OR, 1.55; 95% CI, 1.15–2.10). In Cox modelling, the central location of drusen (at baseline or during the follow‐up) was associated with a 4.41‐fold increased risk (95% CI,1.98–9.81) for an incident late AMD. Conclusion: Central drusen were strongly associated with AMD risk factors and incident late AMD, suggesting that it represents a key marker for AMD progression. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Integrating Metabolomics, Genomics, and Disease Pathways in Age-Related Macular Degeneration: The EYE-RISK Consortium

Author

Arango-Gonzalez, Blanca, Armento, Angela, Badura, Franz, Bhatia, Vaibhav, Bhattacharya, Shomi S., Biarnés, Marc, Borrell, Anna, Calado, Sofia M., Dammeier, Sascha, Cerda, Berta De la, Diaz-Corrales, Francisco J., Diether, Sigrid, Emri, Eszter, Endermann, Tanja, Ferraro, Lucia L., Garcia, Míriam, Honisch, Sabina, Kilger, Ellen, Kortvely, Elod, Lastrucci, Claire, Langen, Hanno, Lengyel, Imre, Luthert, Phil, Monés, Jordi, Nogoceke, Everson, Peto, Tunde, Pool, Frances M., Rodriguez-Bocanegra, Eduardo, Serrano, Luis, Sousa, Jose, Thee, Eric, Ueffing, Marius, Ulrich Bartz-Schmidt, Karl U., Zumbansen, Markus, Acar, İlhan E., Lores-Motta, Laura, Colijn, Johanna M., Meester-Smoor, Magda A., Verzijden, Timo, Cougnard-Gregoire, Audrey, Ajana, Soufiane, Merle, Benedicte M.J., de Breuk, Anita, Heesterbeek, Thomas J., van den Akker, Erik, Daha, Mohamed R., Claes, Birte, Pauleikhoff, Daniel, Hense, Hans-Werner, van Duijn, Cornelia M., Fauser, Sascha, Hoyng, Carel B., Delcourt, Cécile, Klaver, Caroline C.W., Galesloot, Tessel E., and den Hollander, Anneke I.

Published
2020
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14. Prevalence of Age-Related Macular Degeneration in Europe: The Past and the Future

Author

Ajana, Soufiane, Arango-Gonzalez, Blanca, Arndt, Verena, Bhatia, Vaibhav, Bhattacharya, Shomi S., Biarnés, Marc, Borrell, Anna, Bühren, Sebastian, Calado, Sofia M., Colijn, Johanna M., Cougnard-Grégoire, Audrey, Dammeier, Sascha, de Jong, Eiko K., De la Cerda, Berta, Delcourt, Cécile, den Hollander, Anneke I., Diaz-Corrales, Francisco J., Diether, Sigrid, Emri, Eszter, Endermann, Tanja, Ferraro, Lucia L., Garcia, Míriam, Heesterbeek, Thomas J., Honisch, Sabina, Hoyng, Carel B., Kersten, Eveline, Kilger, Ellen, Klaver, Caroline C.W., Langen, Hanno, Lengyel, Imre, Luthert, Phil, Maugeais, Cyrille, Meester-Smoor, Magda, Merle, Bénédicte M.J., Monés, Jordi, Nogoceke, Everson, Peto, Tunde, Pool, Frances M., Rodríguez, Eduardo, Ueffing, Marius, Ulrich Bartz-Schmidt, Karl U., van Leeuwen, Elisabeth M., Verzijden, Timo, Zumbansen, Markus, Acar, Niyazi, Anastosopoulos, Eleftherios, Azuara-Blanco, Augusto, Bergen, Arthur, Bertelsen, Geir, Binquet, Christine, Bird, Alan, Brétillon, Lionel, Bron, Alain, Buitendijk, Gabrielle, Cachulo, Maria Luz, Chakravarthy, Usha, Chan, Michelle, Chang, Petrus, Colijn, Johanna, Creuzot-Garcher, Catherine, Cumberland, Philippa, Cunha-Vaz, José, Daien, Vincent, Deak, Gabor, Delyfer, Marie-Noëlle, den Hollander, Anneke, Dietzel, Martha, Erke, Maja Gran, Fauser, Sascha, Finger, Robert, Fletcher, Astrid, Foster, Paul, Founti, Panayiota, Göbel, Arno, Gorgels, Theo, Grauslund, Jakob, Grus, Franz, Hammond, Christopher, Helmer, Catherine, Hense, Hans-Werner, Hermann, Manuel, Hoehn, René, Hogg, Ruth, Holz, Frank, Hoyng, Carel, Jansonius, Nomdo, Janssen, Sarah, Khawaja, Anthony, Klaver, Caroline, Korobelnik, Jean-François, Lamparter, Julia, Le Goff, Mélanie, Leal, Sergio, Lechanteur, Yara, Lehtimäki, Terho, Lotery, Andrew, Leung, Irene, Mauschitz, Matthias, Merle, Bénédicte, Meyer zu Westrup, Verena, Midena, Edoardo, Miotto, Stefania, Mirshahi, Alireza, Mohan-Saïd, Sadek, Mueller, Michael, Muldrew, Alyson, Nunes, Sandrina, Oexle, Konrad, Piermarocchi, Stefano, Prokofyeva, Elena, Rahi, Jugnoo, Raitakari, Olli, Ribeiro, Luisa, Rougier, Marie-Bénédicte, Sahel, José, Salonikiou, Aggeliki, Sanchez, Clarisa, Schmitz-Valckenberg, Steffen, Schweitzer, Cédric, Segato, Tatiana, Shehata, Jasmin, Silva, Rufino, Silvestri, Giuliana, Simader, Christian, Souied, Eric, Springelkamp, Henriet, Tapp, Robyn, Topouzis, Fotis, Verhoeven, Virginie, Von Hanno, Therese, Vujosevic, Stela, Williams, Katie, Wolfram, Christian, Yip, Jennifer, Zerbib, Jennyfer, Zwiener, Isabella, Buitendijk, Gabriëlle H.S., Alves, Dalila, Cachulo, Maria L., Khawaja, Anthony P., Cougnard-Gregoire, Audrey, Korb, Christina, Erke, Maja G., Anastasopoulos, Eleftherios, Meester-Smoor, Magda A., de Jong, Paulus T.V.M., Vingerling, Johannes R., Pfeiffer, Norbert, Fletcher, Astrid E., and Foster, Paul J.

Published
2017
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15. Increased High-Density Lipoprotein Levels Associated with Age-Related Macular Degeneration: Evidence from the EYE-RISK and European Eye Epidemiology Consortia

Author

Acar, Niyazi, Altay, Lebriz, Anastosopoulos, Eleftherios, Azuara-Blanco, Augusto, Berendschot, Tos, Bergen, Arthur, Bertelsen, Geir, Binquet, Christine, Bird, Alan, Bobak, Martin, Larsen, Morten Bøgelund, Boon, Camiel, Bourne, Rupert, Brétillon, Lionel, Broe, Rebecca, Bron, Alain, Buitendijk, Gabrielle, Cachulo, Maria Luz, Capuano, Vittorio, Carrière, Isabelle, Chakravarthy, Usha, Chan, Michelle, Chang, Petrus, Colijn, Johanna, Cougnard-Grégoire, Audrey, Cree, Angela, Creuzot-Garcher, Catherine, Cumberland, Phillippa, Cunha-Vaz, José, Daien, Vincent, De Jong, Eiko, Deak, Gabor, Delcourt, Cécile, Delyfer, Marie-Noëlle, Hollander, Anneke den, Dietzel, Martha, Erke, Maja Gran, Faria, Pedro, Farinha, Claudia, Fauser, Sascha, Finger, Robert, Fletcher, Astrid, Foster, Paul, Founti, Panayiota, Gorgels, Theo, Grauslund, Jakob, Grus, Franz, Hammond, Christopher, Heesterbeek, Thomas, Hense, Hans-Werner, Hermann, Manuel, Hoehn, René, Hogg, Ruth, Holz, Frank, Hoyng, Carel, Jansonius, Nomdo, Janssen, Sarah, de Jong, Eiko, Khawaja, Anthony, Klaver, Caroline, Korobelnik, Jean-François, Lamparter, Julia, Le Goff, Mélanie, Lehtimäki, Terho, Leung, Irene, Lotery, Andrew, Mauschitz, Matthias, Meester, Magda, Merle, Bénédicte, Meyer zu Westrup, Verena, Midena, Edoardo, Miotto, Stefania, Mirshahi, Alireza, Mohan-Saïd, Sadek, Mueller, Michael, Muldrew, Alyson, Murta, Joaquim, Nickels, Stefan, Nunes, Sandrina, Owen, Christopher, Peto, Tunde, Pfeiffer, Norbert, Piermarocchi, Stefano, Prokofyeva, Elena, Rahi, Jugnoo, Raitakari, Olli, Rauscher, Franziska, Ribeiro, Luisa, Rougier, Marie-Bénédicte, Rudnicka, Alicja, Sahel, José, Salonikiou, Aggeliki, Sanchez, Clarisa, Schick, Tina, Schmitz-Valckenberg, Steffen, Schuster, Alexander, Schweitzer, Cédric, Segato, Tatiana, Shehata, Jasmin, Silva, Rufino, Silvestri, Giuliana, Simader, Christian, Souied, Eric, Speckauskas, Martynas, Springelkamp, Henriet, Tapp, Robyn, Topouzis, Fotis, van Leeuwen, Elisa, Verhoeven, Virginie, Verzijden, Timo, Vingerling, Hans, Von Hanno, Therese, Williams, Katie, Wolfram, Christian, Yip, Jennifer, Zerbib, Jennyfer, Ajana, Soufiane, Arango-Gonzalez, Blanca, Arndt, Verena, Bhatia, Vaibhav, Bhattacharya, Shomi S., Biarnés, Marc, Borrell, Anna, Bühren, Sebastian, Calado, Sofia M., Colijn, Johanna M., Dammeier, Sascha, de Jong, Eiko K., De la Cerda, Berta, den Hollander, Anneke I., Diaz-Corrales, Francisco J., Diether, Sigrid, Emri, Eszter, Endermann, Tanja, Ferraro, Lucia L., Garcia, Míriam, Heesterbeek, Thomas J., Honisch, Sabina, Hoyng, Carel B., Kersten, Eveline, Kilger, Ellen, Klaver, Caroline C.W., Langen, Hanno, Lengyel, Imre, Luthert, Phil, Maugeais, Cyrille, Meester-Smoor, Magda, Merle Inserm, Bénédicte M.J., Monés, Jordi, Nogoceke, Everson, Pool, Frances M., Rodríguez, Eduardo, Ueffing, Marius, Ulrich Bartz-Schmidt, Karl U., van Leeuwen, Elisabeth M., Zumbansen, Markus, Demirkan, Ayse, Meester-Smoor, Magda A., Merle, Benedicte M.J., Papageorgiou, Grigorios, Ahmad, Shahzad, Mulder, Monique T., Costa, Miguel Angelo, Benlian, Pascale, Bron, Alain M., Claes, Birte, Foster, Paul J., Hammond, Christopher J., Khawaja, Anthony P., Korobelnik, Jean-Francois, Souied, Eric H., Williams, Katie M., and van Duijn, Cornelia M.

Published
2019
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16. Mediterranean Diet and Incidence of Advanced Age-Related Macular Degeneration: The EYE-RISK Consortium

Author

Ajana, Soufiane, Arango-Gonzalez, Blanca, Armento, Angela, Arndt, Verena, Bhatia, Vaibhav, Bhattacharya, Shomi S., Biarnés, Marc, Borrell, Anna, Bühren, Sebastian, Calado, Sofia M., Colijn, Johanna M., Cougnard-Grégoire, Audrey, Dammeier, Sascha, de Jong, Eiko K., De la Cerda, Berta, Delcourt, Cécile, den Hollander, Anneke I., Diaz-Corrales, Francisco J., Diether, Sigrid, Emri, Eszter, Endermann, Tanja, Ferraro, Lucia L., Garcia, Míriam, Heesterbeek, Thomas J., Honisch, Sabina, Hoyng, Carel B., Kersten, Eveline, Kilger, Ellen, Klaver, Caroline C.W., Langen, Hanno, Lengyel, Imre, Luthert, Phil, Maugeais, Cyrille, Meester-Smoor, Magda, Merle, Bénédicte M.J., Monés, Jordi, Nogoceke, Everson, Peto, Tunde, Pool, Frances M., Rodríguez, Eduardo, Ueffing, Marius, Ulrich Bartz-Schmidt, Karl U., van Leeuwen, Elisabeth M., Verzijden, Timo, Zumbansen, Markus, Vasiliev, Vassil, de Koning-Backus, Alexandra P.M., Delyfer, Marie-Noëlle, Kiefte-de Jong, Jessica C., Féart, Catherine, Samieri, Cécilia, Franco, Oscar H., and Korobelnik, Jean-François

Published
2019
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17. A new perspective on lipid research in age-related macular degeneration

Author

van Leeuwen, Elisabeth M., Emri, Eszter, Merle, Benedicte M.J., Colijn, Johanna M., Kersten, Eveline, Cougnard-Gregoire, Audrey, Dammeier, Sascha, Meester-Smoor, Magda, Pool, Frances M., de Jong, Eiko K., Delcourt, Cécile, Rodrigez-Bocanegra, Eduardo, Biarnés, Marc, Luthert, Philip J., Ueffing, Marius, Klaver, Caroline C.W., Nogoceke, Everson, den Hollander, Anneke I., and Lengyel, Imre

Published
2018
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18. Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population

Author

Acar, Niyazi, Anastosopoulos, Eleftherios, Azuara-Blanco, Augusto, Berendschot, Tos, Bergen, Arthur, Bertelsen, Geir, Binquet, Christine, Bird, Alan, Bobak, Martin, Larsen, Morten Bøgelund, Boon, Camiel, Bourne, Rupert, Brétillon, Lionel, Broe, Rebecca, Bron, Alain, Buitendijk, Gabrielle, Cachulo, Maria Luz, Capuano, Vittorio, Carrière, Isabelle, Chakravarthy, Usha, Chan, Michelle, Chang, Petrus, Colijn, Johanna, Cougnard-Grégoire, Audrey, Cree, Angela, Creuzot-Garcher, Catherine, Cumberland, Phillippa, Cunha-Vaz, José, Daien, Vincent, De Jong, Eiko, Deak, Gabor, Delcourt, Cécile, Delyfer, Marie-Noëlle, Hollander, Anneke den, Dietzel, Martha, Erke, Maja Gran, Faria, Pedro, Farinha, Claudia, Fauser, Sascha, Finger, Robert, Fletcher, Astrid, Foster, Paul, Founti, Panayiota, Gorgels, Theo, Grauslund, Jakob, Grus, Franz, Hammond, Christopher, Hense, Hans-Werner, Hermann, Manuel, Hoehn, René, Hogg, Ruth, Holz, Frank, Hoyng, Carel, Jansonius, Nomdo, Janssen, Sarah, Kersten, Eveline, Khawaja, Anthony, Klaver, Caroline, Korobelnik, Jean-François, Lamparter, Julia, Le Goff, Mélanie, Lechanteur, Yara, Lehtimäki, Terho, Leung, Irene, Lotery, Andrew, Mauschitz, Matthias, Meester, Magda, Merle, Bénédicte, Meyer zu Westrup, Verena, Midena, Edoardo, Miotto, Stefania, Mirshahi, Alireza, Mohan-Saïd, Sadek, Mueller, Michael, Muldrew, Alyson, Murta, Joaquim, Nickels, Stefan, Nunes, Sandrina, Owen, Christopher, Peto, Tunde, Pfeiffer, Norbert, Piermarocchi, Stefano, Prokofyeva, Elena, Rahi, Jugnoo, Raitakari, Olli, Rauscher, Franziska, Ribeiro, Luisa, Rougier, Marie-Bénédicte, Rudnicka, Alicja, Sahel, José, Salonikiou, Aggeliki, Sanchez, Clarisa, Schmitz-Valckenberg, Steffen, Schuster, Alexander, Schweitzer, Cédric, Segato, Tatiana, Shehata, Jasmin, Silva, Rufino, Silvestri, Giuliana, Simader, Christian, Souied, Eric, Speckauskas, Martynas, Springelkamp, Henriet, Tapp, Robyn, Topouzis, Fotis, van Leeuwen, Elisa, Verhoeven, Virginie, Verzijden, Timo, Von Hanno, Therese, Wiedemann, Peter, Williams, Katie, Wolfram, Christian, Yip, Jennifer, Zerbib, Jennyfer, Mauschitz, Matthias M., Bonnemaijer, Pieter W.M., Diers, Kersten, Rauscher, Franziska G., Elze, Tobias, Engel, Christoph, Loeffler, Markus, Colijn, Johanna Maria, Ikram, M. Arfan, Vingerling, Johannes R., Williams, Katie M., Hammond, Christopher J., Bron, Alain M., Holz, Frank G., Klaver, Caroline C.W., Breteler, Monique M.B., and Finger, Robert P.

Published
2018
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19. The Decreasing Prevalence of Nonrefractive Visual Impairment in Older Europeans: A Meta-analysis of Published and Unpublished Data

Author

Acar, Niyazi, Anastosopoulos, Eleftherios, Azuara-Blanco, Augusto, Berendschot, Tos, Bergen, Arthur, Bertelsen, Geir, Binquet, Christine, Bird, Alan, Bobak, Martin, Boon, Camiel, Brétillon, Lionel, Broe, Rebecca, Bron, Alain, Buitendijk, Gabrielle, Cachulo, Maria Luz, Capuano, Vittorio, Carrière, Isabelle, Chakravarthy, Usha, Chan, Michelle, Chang, Petrus, Colijn, Johanna, Cougnard-Grégoire, Audrey, Cree, Angela, Creuzot-Garcher, Catherine, Cumberland, Phillippa, Cunha-Vaz, José, Daien, Vincent, De Jong, Eiko, Deak, Gabor, Delcourt, Cécile, Delyfer, Marie-Noëlle, den Hollander, Anneke, Dietzel, Martha, Erke, Maja Gran, Faria, Pedro, Farinha, Claudia, Fauser, Sascha, Finger, Robert, Fletcher, Astrid, Foster, Paul, Founti, Panayiota, Gorgels, Theo, Grauslund, Jakob, Grus, Franz, Hammond, Christopher, Hansen, Morten, Helmer, Catherine, Hense, Hans-Werner, Hermann, Manuel, Hoehn, René, Hogg, Ruth, Holz, Frank, Hoyng, Carel, Jansonius, Nomdo, Janssen, Sarah, Kersten, Eveline, Khawaja, Anthony, Klaver, Caroline, Korobelnik, Jean-François, Lamparter, Julia, Le Goff, Mélanie, Lechanteur, Yara, Lehtimäki, Terho, Leung, Irene, Lotery, Andrew, Mauschitz, Matthias, Meester, Magda, Merle, Bénédicte, Meyer zu Westrup, Verena, Midena, Edoardo, Miotto, Stefania, Mirshahi, Alireza, Mohan-Saïd, Sadek, Mueller, Michael, Muldrew, Alyson, Murta, Joaquim, Nickels, Stefan, Nunes, Sandrina, Owen, Christopher, Peto, Tunde, Pfeiffer, Norbert, Piermarocchi, Stefano, Prokofyeva, Elena, Rahi, Jugnoo, Raitakari, Olli, Rauscher, Franziska, Ribeiro, Luisa, Rougier, Marie-Bénédicte, Rudnicka, Alicja, Sahel, José, Salonikiou, Aggeliki, Sanchez, Clarisa, Schmitz-Valckenberg, Steffen, Schouten, Johannes, Schuster, Alexander, Schweitzer, Cédric, Segato, Tatiana, Shehata, Jasmin, Silva, Rufino, Silvestri, Giuliana, Simader, Christian, Souied, Eric, Speckauskas, Martynas, Springelkamp, Henriet, Tapp, Robyn, Topouzis, Fotis, van Leeuwen, Elisa, Verhoeven, Virginie, Verzijden, Timo, Von Hanno, Therese, Vujosevic, Stela, Wiedemann, Peter, Williams, Katie, Wolfram, Christian, Yip, Jennifer, Zerbib, Jennyfer, von Hanno, Therese, Khawaja, Anthony P., Verhoeven, Virginie J.M., Hogg, Ruth E., Höhn, René, Colijn, Johanna M., Buitendijk, Gabriëlle H.S., Evans, Jennifer, Nitsch, Dorothea, Yip, Jennifer L.Y., Foster, Paul J., and Klaver, Caroline C.W.

Published
2018
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22. Associations with intraocular pressure across Europe: The European Eye Epidemiology (E3) Consortium

Author

Khawaja, Anthony P., Springelkamp, Henriët, Creuzot-Garcher, Catherine, Delcourt, Cécile, Hofman, Albert, Höhn, René, Iglesias, Adriana I., Wolfs, Roger C. W., Korobelnik, Jean-François, Silva, Rufino, Topouzis, Fotis, Williams, Katie M., Bron, Alain M., Buitendijk, Gabriëlle H. S., Cachulo, Maria da Luz, Cougnard-Grégoire, Audrey, Dartigues, Jean-François, Hammond, Christopher J., Pfeiffer, Norbert, Salonikiou, Angeliki, van Duijn, Cornelia M., Vingerling, Johannes R., Luben, Robert N., Mirshahi, Alireza, Lamparter, Julia, Klaver, Caroline C. W., Jansonius, Nomdo M., Foster, Paul J., Acar, Niyazi, Anastosopoulos, Eleftherios, Azuara-Blanco, Augusto, Bergen, Arthur, Bertelsen, Geir, Binquet, Christine, Bird, Alan, Brétillon, Lionel, Bron, Alain, Buitendijk, Gabrielle, Cachulo, Maria Luz, Chakravarthy, Usha, Chan, Michelle, Chang, Petrus, Colijn, Annemarie, Cougnard-Grégoire, Audrey, Creuzot-Garcher, Catherine, Cumberland, Philippa, Cunha-Vaz, José, Daien, Vincent, Deak, Gabor, Delcourt, Cécile, Delyfer, Marie-Noëlle, Hollander, Anneke den, Dietzel, Martha, Erke, Maja Gran, Fauser, Sascha, Finger, Robert, Fletcher, Astrid, Foster, Paul, Founti, Panayiota, Göbel, Arno, Gorgels, Theo, Grauslund, Jakob, Grus, Franz, Hammond, Christopher, Helmer, Catherine, Hense, Hans-Werner, Hermann, Manuel, Hoehn, René, Hogg, Ruth, Holz, Frank, Hoyng, Carel, Jansonius, Nomdo, Janssen, Sarah, Khawaja, Anthony, Klaver, Caroline, Korobelnik, Jean-François, Lamparter, Julia, Le Goff, Mélanie, Leal, Sergio, Lechanteur, Yara, Lehtimäki, Terho, Lotery, Andrew, Leung, Irene, Mauschitz, Matthias, Merle, Bénédicte, Meyer zu Westrup, Verena, Midena, Edoardo, Miotto, Stefania, Mirshahi, Alireza, Mohan-Saïd, Sadek, Muldrew, Alyson, Mueller, Michael, Nunes, Sandrina, Oexle, Konrad, Peto, Tunde, Piermarocchi, Stefano, Prokofyeva, Elena, Rahi, Jugnoo, Raitakari, Olli, Ribeiro, Luisa, Rougier, Marie-Bénédicte, Sahel, José, Salonikiou, Aggeliki, Sanchez, Clarisa, Schmitz-Valckenberg, Steffen, Schweitzer, Cédric, Segato, Tatiana, Shehata, Jasmin, Silva, Rufino, Silvestri, Giuliana, Simader, Christian, Souied, Eric, Springelkamp, Henriet, Tapp, Robyn, Topouzis, Fotis, Verhoeven, Virginie, Von Hanno, Therese, Vujosevic, Stela, Williams, Katie, Wolfram, Christian, Yip, Jennifer, Zerbib, Jennyfer, Zwiener, Isabella, and On behalf of the European Eye Epidemiology (E³) Consortium

Published
2016
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23. Association of lipid-lowering drugs and antidiabetic drugs with age-related macular degeneration:A meta-analysis in Europeans

Author

Mauschitz, Matthias M., Verzijden, Timo, Schuster, Alexander K., Elbaz, Hisham, Pfeiffer, Norbert, Khawaja, Anthony, Luben, Robert N., Foster, Paul J., Rauscher, Franziska G., Wirkner, Kerstin, Kirsten, Toralf, Jonas, Jost B., Bikbov, Mukharram M., Hogg, Ruth, Peto, Tunde, Cougnard-Grégoire, Audrey, Bertelsen, Geir, Erke, Maja Gran, Topouzis, Fotis, Giannoulis, Dimitrios A., Brandl, Caroline, Heid, Iris M., Creuzot-Garcher, Catherine P., Gabrielle, Pierre Henry, Hense, Hans Werner, Pauleikhoff, Daniel, Barreto, Patricia, Coimbra, Rita, Piermarocchi, Stefano, Daien, Vincent, Holz, Frank G., Delcourt, Cecile, Finger, Robert P., Mauschitz, Matthias M., Verzijden, Timo, Schuster, Alexander K., Elbaz, Hisham, Pfeiffer, Norbert, Khawaja, Anthony, Luben, Robert N., Foster, Paul J., Rauscher, Franziska G., Wirkner, Kerstin, Kirsten, Toralf, Jonas, Jost B., Bikbov, Mukharram M., Hogg, Ruth, Peto, Tunde, Cougnard-Grégoire, Audrey, Bertelsen, Geir, Erke, Maja Gran, Topouzis, Fotis, Giannoulis, Dimitrios A., Brandl, Caroline, Heid, Iris M., Creuzot-Garcher, Catherine P., Gabrielle, Pierre Henry, Hense, Hans Werner, Pauleikhoff, Daniel, Barreto, Patricia, Coimbra, Rita, Piermarocchi, Stefano, Daien, Vincent, Holz, Frank G., Delcourt, Cecile, and Finger, Robert P.

Abstract

Background/aims: To investigate the association of commonly used systemic medications with prevalent age-related macular degeneration (AMD) in the general population. Methods: We included 38 694 adults from 14 population-based and hospital-based studies from the European Eye Epidemiology consortium. We examined associations between the use of systemic medications and any prevalent AMD as well as any late AMD using multivariable logistic regression modelling per study and pooled results using random effects meta-analysis. Results: Between studies, mean age ranged from 61.5±7.1 to 82.6±3.8 years and prevalence ranged from 12.1% to 64.5% and from 0.5% to 35.5% for any and late AMD, respectively. In the meta-analysis of fully adjusted multivariable models, lipid-lowering drugs (LLD) and antidiabetic drugs were associated with lower prevalent any AMD (OR 0.85, 95% CI=0.79 to 0.91 and OR 0.78, 95% CI=0.66 to 0.91). We found no association with late AMD or with any other medication. Conclusion: Our study indicates a potential beneficial effect of LLD and antidiabetic drug use on prevalence of AMD across multiple European cohorts. Our findings support the importance of metabolic processes in the multifactorial aetiology of AMD.

Published
2023

24. Association of lipid-lowering drugs and antidiabetic drugs with age-related macular degeneration: a meta-analysis in Europeans.

Author

Mauschitz, Matthias M., Verzijden, Timo, Schuster, Alexander K., Elbaz, Hisham, Pfeiffer, Norbert, Khawaja, Anthony, Luben, Robert N., Foster, Paul J., Rauscher, Franziska G., Wirkner, Kerstin, Kirsten, Toralf, Jonas, Jost B., Bikbov, Mukharram M., Hogg, Ruth, Peto, Tunde, Cougnard-Grégoire, Audrey, Bertelsen, Geir, Erke, Maja Gran, Topouzis, Fotis, and Giannoulis, Dimitrios A.

Abstract

Background/aims To investigate the association of commonly used systemic medications with prevalent age-related macular degeneration (AMD) in the general population. Methods We included 38 694 adults from 14 population-based and hospital-based studies from the European Eye Epidemiology consortium. We examined associations between the use of systemic medications and any prevalent AMD as well as any late AMD using multivariable logistic regression modelling per study and pooled results using random effects meta-analysis. Results Between studies, mean age ranged from 61.5±7.1 to 82.6±3.8 years and prevalence ranged from 12.1% to 64.5% and from 0.5% to 35.5% for any and late AMD, respectively. In the meta-analysis of fully adjusted multivariable models, lipid-lowering drugs (LLD) and antidiabetic drugs were associated with lower prevalent any AMD (OR 0.85, 95% CI=0.79 to 0.91 and OR 0.78, 95% CI=0.66 to 0.91). We found no association with late AMD or with any other medication. Conclusion Our study indicates a potential beneficial effect of LLD and antidiabetic drug use on prevalence of AMD across multiple European cohorts. Our findings support the importance of metabolic processes in the multifactorial aetiology of AMD. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Increasing Prevalence of Myopia in Europe and the Impact of Education

Author

Williams, Katie M., Bertelsen, Geir, Cumberland, Phillippa, Wolfram, Christian, Verhoeven, Virginie J.M., Anastasopoulos, Eleftherios, Buitendijk, Gabriëlle H.S., Cougnard-Grégoire, Audrey, Creuzot-Garcher, Catherine, Erke, Maja Gran, Hogg, Ruth, Höhn, René, Hysi, Pirro, Khawaja, Anthony P., Korobelnik, Jean-François, Ried, Janina, Vingerling, Johannes R., Bron, Alain, Dartigues, Jean-François, Fletcher, Astrid, Hofman, Albert, Kuijpers, Robert W.A.M., Luben, Robert N., Oxele, Konrad, Topouzis, Fotis, von Hanno, Therese, Mirshahi, Alireza, Foster, Paul J., van Duijn, Cornelia M., Pfeiffer, Norbert, Delcourt, Cécile, Klaver, Caroline C.W., Rahi, Jugnoo, and Hammond, Christopher J.

Published
2015
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27. Association of lipid-lowering drugs and antidiabetic drugs with age-related macular degeneration: a meta-analysis in Europeans

Author

Mauschitz, Matthias M, primary, Verzijden, Timo, additional, Schuster, Alexander K, additional, Elbaz, Hisham, additional, Pfeiffer, Norbert, additional, Khawaja, Anthony, additional, Luben, Robert N, additional, Foster, Paul J, additional, Rauscher, Franziska G, additional, Wirkner, Kerstin, additional, Kirsten, Toralf, additional, Jonas, Jost B, additional, Bikbov, Mukharram M, additional, Hogg, Ruth, additional, Peto, Tunde, additional, Cougnard-Grégoire, Audrey, additional, Bertelsen, Geir, additional, Erke, Maja Gran, additional, Topouzis, Fotis, additional, Giannoulis, Dimitrios A, additional, Brandl, Caroline, additional, Heid, Iris M, additional, Creuzot-Garcher, Catherine P, additional, Gabrielle, Pierre-Henry, additional, Hense, Hans-Werner, additional, Pauleikhoff, Daniel, additional, Barreto, Patricia, additional, Coimbra, Rita, additional, Piermarocchi, Stefano, additional, Daien, Vincent, additional, Holz, Frank G, additional, Delcourt, Cecile, additional, and Finger, Robert P, additional

Published
2022
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28. Prevalence of refractive error in Europe: the European Eye Epidemiology (E³) Consortium

Author

Williams, Katie M., Verhoeven, Virginie J. M., Cumberland, Phillippa, Bertelsen, Geir, Wolfram, Christian, Buitendijk, Gabriëlle H. S., Hofman, Albert, van Duijn, Cornelia M., Vingerling, Johannes R., Kuijpers, Robert W. A. M., Höhn, René, Mirshahi, Alireza, Khawaja, Anthony P., Luben, Robert N., Erke, Maja Gran, von Hanno, Therese, Mahroo, Omar, Hogg, Ruth, Gieger, Christian, Cougnard-Grégoire, Audrey, Anastasopoulos, Eleftherios, Bron, Alain, Dartigues, Jean-François, Korobelnik, Jean-François, Creuzot-Garcher, Catherine, Topouzis, Fotis, Delcourt, Cécile, Rahi, Jugnoo, Meitinger, Thomas, Fletcher, Astrid, Foster, Paul J., Pfeiffer, Norbert, Klaver, Caroline C. W., and Hammond, Christopher J.

Published
2015

30. Association of long-term exposure to ambient air pollution with retinal neurodegeneration on optical coherence tomography: the prospective Alienor study

Author

Gayraud, Laure, primary, Mortamais, Marion, additional, Schweitzer, Cédric, additional, De Hoog, Kees, additional, Cougnard-Grégoire, Audrey, additional, Korobelnik, Jean-François, additional, Delyfer, Marie-Noelle, additional, Rougier, Marie-Bénédicte, additional, Leffondré, Karen, additional, Helmer, Catherine, additional, Vienneau, Danielle, additional, Berr, Claudine, additional, and Delcourt, Cécile, additional

Published
2022
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33. Development of a Genotype Assay for Age-Related Macular Degeneration: The EYE-RISK Consortium

Author

de Breuk, Anita, Acar, Ilhan E., Kersten, Eveline, Schijvenaars, Mascha M.V.A.P., Colijn, Johanna M., Haer-Wigman, Lonneke, Bakker, Bjorn, de Jong, Sarah, Meester-Smoor, Magda, Verzijden, Timo, Missotten, Tom O.A.R., Monés, Jordi, Biarnés, Marc, Pauleikhoff, Daniel, Hense, Hans W., Silva, Rufino, Nunes, Sandrina, Melo, Joana B., Fauser, Sascha, Hoyng, Carel B., Ueffing, Marius, Coenen, Marieke J.H., Klaver, Caroline C.W., den Hollander, Anneke I., Ajana, Soufiane, Arango-Gonzalez, Blanca, Badura, Franz, De la Cerda, Berta, Borrell, Anna, Cougnard-Grégoire, Audrey, Dammeier, Sascha, de Jong, Eiko K., Delcourt, Cécile, Diether, Sigrid, Emri, Eszter, Endermann, Tanja, Ferraro, Lucia L., Garcia, Míriam, Heesterbeek, Thomas J., Honisch, Sabina, Ikram, A., Kilger, Ellen, Langen, Hanno, Lengyel, Imre, Luthert, Phil, Merle, Bénédicte M.J., Nogoceke, Everson, Peto, Tunde, Pool, Frances M., Rodríguez, Eduardo, Vingerling, Johannes, and Zumbansen, Markus

Subjects
genetic structures, sense organs, eye diseases
Abstract

PurposeTo develop a genotype assay to assess associations with common and rare age-related macular degeneration (AMD) risk variants, to calculate an overall genetic risk score (GRS), and to identify potential misdiagnoses with inherited macular dystrophies that mimic AMD.DesignCase-control study.ParticipantsIndividuals (n = 4740) from 5 European cohorts.MethodsWe designed single-molecule molecular inversion probes for target selection and used next generation sequencing to sequence 87 single nucleotide polymorphisms (SNPs), coding and splice-site regions of 10 AMD-(related) genes (ARMS2, C3, C9, CD46, CFB, CFH, CFI, HTRA1, TIMP3, and SLC16A8), and 3 genes that cause inherited macular dystrophies (ABCA4, CTNNA1, and PRPH2). Genetic risk scores for common AMD risk variants were calculated based on effect size and genotype of 52 AMD-associated variants. Frequency of rare variants was compared between late AMD patients and control individuals with logistic regression analysis.Main Outcome MeasuresGenetic risk score, association of genetic variants with AMD, and genotype–phenotype correlations.ResultsWe observed high concordance rates between our platform and other genotyping platforms for the 69 successfully genotyped SNPs (>96%) and for the rare variants (>99%). We observed a higher GRS for patients with late AMD compared with patients with early/intermediate AMD (P < 0.001) and individuals without AMD (P < 0.001). A higher proportion of pathogenic variants in the CFH (odds ratio [OR] = 2.88; P = 0.006), CFI (OR = 4.45; P = 0.005), and C3 (OR = 6.56; P = 0.0003) genes was observed in late AMD patients compared with control individuals. In 9 patients, we identified pathogenic variants in the PRPH2, ABCA4, and CTNNA1 genes, which allowed reclassification of these patients as having inherited macular dystrophy.ConclusionsThis study reports a genotype assay for common and rare AMD genetic variants, which can identify individuals at intermediate to high genetic risk of late AMD and enables differential diagnosis of AMD-mimicking dystrophies. Our study supports sequencing of CFH, CFI, and C3 genes because they harbor rare high-risk variants. Carriers of these variants could be amendable for new treatments for AMD that currently are under development.

Published
2021
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34. Development of a Genotype Assay for Age-Related Macular Degeneration

Author

de Breuk, Anita, primary, Acar, Ilhan E., additional, Kersten, Eveline, additional, Schijvenaars, Mascha M.V.A.P., additional, Colijn, Johanna M., additional, Haer-Wigman, Lonneke, additional, Bakker, Bjorn, additional, de Jong, Sarah, additional, Meester-Smoor, Magda A., additional, Verzijden, Timo, additional, Missotten, Tom O.A.R., additional, Monés, Jordi, additional, Biarnés, Marc, additional, Pauleikhoff, Daniel, additional, Hense, Hans W., additional, Silva, Rufino, additional, Nunes, Sandrina, additional, Melo, Joana B., additional, Fauser, Sascha, additional, Hoyng, Carel B., additional, Ueffing, Marius, additional, Coenen, Marieke J.H., additional, Klaver, Caroline C.W., additional, den Hollander, Anneke I., additional, Ajana, Soufiane, additional, Cougnard-Grégoire, Audrey, additional, Delcourt, Cécile, additional, Merle, Bénédicte M.J., additional, Arango-Gonzalez, Blanca, additional, Dammeier, Sascha, additional, Diether, Sigrid, additional, Honisch, Sabina, additional, Kilger, Ellen, additional, Endermann, Tanja, additional, Zumbansen, Markus, additional, Badura, Franz, additional, De la Cerda, Berta, additional, Borrell, Anna, additional, Ferraro, Lucia L., additional, Garcia, Míriam, additional, Rodríguez, Eduardo, additional, Ikram, A., additional, Meester-Smoor, Magda, additional, Vingerling, Johannes, additional, Heesterbeek, Thomas J., additional, de Jong, Eiko K., additional, Acar, I. Erkin, additional, de Breuk, Anita, additional, Emri, Eszter, additional, Lengyel, Imre, additional, Langen, Hanno, additional, Nogoceke, Everson, additional, Peto, Tunde, additional, Luthert, Phil, additional, and Pool, Frances M., additional

Published
2021
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35. Genetic risk, lifestyle, and AMD in Europe. The EYE-RISK consortium

Author

Colijn, Johanna Maria, Meester, Magda, Verzijden, T., de Breuk, A., SILVA, R., Merle, Bénédicte M. J., Cougnard-Grégoire, Audrey, Hoyng, Carel B., Fauser, Sascha, Coolen, T., Creuzot-Garcher, Catherine, Hense, H.W., UEFFING, M., Delcourt, Cécile, den Hollander, Anneke I., Klaver, Caroline C. W., EYE-RISK consortium, ., Erasmus University Medical Center [Rotterdam] (Erasmus MC), Radboud University Medical Center [Nijmegen], Coimbra Institute for Clinical and Biomedical Research [Coimbra, Portugal] (iCBR - Faculty of Medicine), University of Coimbra [Portugal] (UC), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), University Hospital of Cologne [Cologne], King‘s College London, Service d'Ophtalmologie (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Muenster, University of Tübingen, European Commission (grant number 634479) + Erasmus Medical Center + Rotterdam Eye Hospital through the CORR (Combined Ophthalmic Research Rotterdam) Foundation + Uitzicht (grant number 2015-36)., and Julien, Sabine

Subjects
Europe, age-related macular degeneration (AMD), [SDV.MHEP.OS] Life Sciences [q-bio]/Human health and pathology/Sensory Organs, pathways, population, genetics, [SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs, eye diseases
Abstract

International audience; PURPOSE: Age-related macular degeneration(AMD) is a common multifactorial disease in elderly with a prominent genetic basis. Many risk variants have been identified, but the interpretation is still challenging. We investigated the genetic distribution of AMD-associated risk variants in a large European consortium, calculated attributable, and pathway-specific genetic risks, and assessed the influence of lifestyle on genetic outcomes. DESIGN: Pooled analysis of cross-sectional data from the E3 consortium. PARTICIPANTS: 17.174 individuals aged 45+ participating in 6 population-based cohort studies, 2 clinic based studies, 1 case-control study. METHODS: AMD was diagnosed and graded based on fundus photographs. Data on genetics, lifestyle, and diet were harmonized and completed where necessary. Minor allele frequencies and population attributable fraction (PAF) were calculated per single nucleotide polymorphism (SNP). A total genetic risk score (GRS) and pathway-specific risk scores (complement, lipid, extra-cellular matrix, other) were constructed based on the dosage of SNPs and conditional beta's; a lifestyle score was constructed based on smoking and dietary intake. RESULTS: The risk variants with the largest difference between late AMD cases and controls, and the highest PAFs were located in ARMS2 (rs3750846) and CHF (rs570618 and rs10922109). Both risk increasing and protective variants had the highest PAFs. Combining all genetic variants, the total genetic risk score ranged from -3.50 to 4.63, was normally distributed and increased with AMD severity. Of the late AMD cases, 1581/1777 (89%) had a positive total GRS. The complement pathway and ARMS2 were by far the most prominent genetic pathways contributing to late AMD (positive GRS 90% of late cases), but risk in three pathways was most frequent (35% of late cases). Lifestyle was a strong determinant of the outcome in each genetic risk category; unfavorable lifestyle increased the risk of late AMD at least twofold. CONCLUSIONS: Genetic risk variants contribute to late AMD in the majority of cases. However, lifestyle factors have a strong influence on the outcome of genetic risk, and should be a strong focus in patient management. Genetic risks in ARMS2 and the complement pathway are present in the majority of late AMD, but are mostly combined with risks in other pathways.

Published
2021
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36. Plasma Lutein, a Nutritional Biomarker for Development of Advanced Age-Related Macular Degeneration: The Alienor Study

Author

Merle, Bénédicte M. J., primary, Cougnard-Grégoire, Audrey, additional, Korobelnik, Jean-François, additional, Schalch, Wolfgang, additional, Etheve, Stéphane, additional, Rougier, Marie-Bénédicte, additional, Féart, Catherine, additional, Samieri, Cécilia, additional, Delyfer, Marie-Noëlle, additional, and Delcourt, Cécile, additional

Published
2021
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37. Predicting Progression to Advanced Age-Related Macular Degeneration from Clinical, Genetic, and Lifestyle Factors Using Machine Learning

Author

Ajana, Soufiane, Cougnard-Grégoire, Audrey, Colijn, Johanna M, Merle, Bénédicte M J, Verzijden, Timo, de Jong, Paulus T V M, Hofman, Albert, Vingerling, Johannes R, Hejblum, Boris P, Korobelnik, Jean-François, Meester-Smoor, Magda A, Ueffing, Marius, Jacqmin-Gadda, Hélène, Klaver, Caroline C W, Delcourt, Cécile, EYE-RISK consortium, Ajana, Soufiane, Cougnard-Grégoire, Audrey, Colijn, Johanna M, Merle, Bénédicte M J, Verzijden, Timo, de Jong, Paulus T V M, Hofman, Albert, Vingerling, Johannes R, Hejblum, Boris P, Korobelnik, Jean-François, Meester-Smoor, Magda A, Ueffing, Marius, Jacqmin-Gadda, Hélène, Klaver, Caroline C W, Delcourt, Cécile, and EYE-RISK consortium

Abstract

PURPOSE: Current prediction models for advanced age-related macular degeneration (AMD) are based on a restrictive set of risk factors. The objective of this study was to develop a comprehensive prediction model applying a machine learning algorithm allowing selection of the most predictive risk factors automatically.DESIGN: Two population-based cohort studies.PARTICIPANTS: The Rotterdam Study I (RS-I; training set) included 3838 participants 55 years of age or older, with a median follow-up period of 10.8 years, and 108 incident cases of advanced AMD. The Antioxydants, Lipids Essentiels, Nutrition et Maladies Oculaires (ALIENOR) study (test set) included 362 participants 73 years of age or older, with a median follow-up period of 6.5 years, and 33 incident cases of advanced AMD.METHODS: The prediction model used the bootstrap least absolute shrinkage and selection operator (LASSO) method for survival analysis to select the best predictors of incident advanced AMD in the training set. Predictive performance of the model was assessed using the area under the receiver operating characteristic curve (AUC).MAIN OUTCOME MEASURES: Incident advanced AMD (atrophic, neovascular, or both), based on standardized interpretation of retinal photographs.RESULTS: The prediction model retained (1) age, (2) a combination of phenotypic predictors (based on the presence of intermediate drusen, hyperpigmentation in one or both eyes, and Age-Related Eye Disease Study simplified score), (3) a summary genetic risk score based on 49 single nucleotide polymorphisms, (4) smoking, (5) diet quality, (6) education, and (7) pulse pressure. The cross-validated AUC estimation in RS-I was 0.92 (95% confidence interval [CI], 0.88-0.97) at 5 years, 0.92 (95% CI, 0.90-0.95) at 10 years, and 0.91 (95% CI, 0.88-0.94) at 15 years. In ALIENOR, the AUC reached 0.92 at 5 years (95% CI, 0.87-0.98). In terms of calibration, the model tended to underestimate the cumulative i

Published
2021

38. Predicting Progression to Advanced Age-Related Macular Degeneration from Clinical, Genetic, and Lifestyle Factors Using Machine Learning

Author

Ajana, Soufiane, primary, Cougnard-Grégoire, Audrey, additional, Colijn, Johanna M., additional, Merle, Bénédicte M.J., additional, Verzijden, Timo, additional, de Jong, Paulus T.V.M., additional, Hofman, Albert, additional, Vingerling, Johannes R., additional, Hejblum, Boris P., additional, Korobelnik, Jean-François, additional, Meester-Smoor, Magda A., additional, Ueffing, Marius, additional, Jacqmin-Gadda, Hélène, additional, Klaver, Caroline C.W., additional, Delcourt, Cécile, additional, Acar, Erkin I., additional, Arango-Gonzalez, Blanca, additional, Armento, Angela, additional, Badura, Franz, additional, Bhatia, Vaibhav, additional, Bhattacharya, Shomi S., additional, Biarnés, Marc, additional, Borrell, Anna, additional, Calado, Sofia M., additional, Dammeier, Sascha, additional, de Breuk, Anita, additional, De la Cerda, Berta, additional, den Hollander, Anneke I., additional, Diaz-Corrales, Francisco J., additional, Diether, Sigrid, additional, Emri, Eszter, additional, Endermann, Tanja, additional, Ferraro, Lucia L., additional, Garcia, Míriam, additional, Heesterbeek, Thomas J., additional, Honisch, Sabina, additional, Hoyng, Carel B., additional, Kilger, Ellen, additional, Kortvely, Elod, additional, Lastrucci, Claire, additional, Langen, Hanno, additional, Lengyel, Imre, additional, Luthert, Phil, additional, Monés, Jordi, additional, Nogoceke, Everson, additional, Peto, Tunde, additional, Pool, Frances M., additional, Rodriguez-Bocanegra, Eduardo, additional, Serrano, Luis, additional, Sousa, Jose, additional, Thee, Eric, additional, Ulrich Bartz-Schmidt, Karl U., additional, and Zumbansen, Markus, additional

Published
2021
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40. Response to Comment on Foussard et al. Skin Autofluorescence of Pregnant Women With Diabetes Predicts the Macrosomia of Their Children. Diabetes 2019;68:1663–1669

Author

Foussard, Ninon, primary, Cougnard-Grégoire, Audrey, additional, Rajaobelina, Kalina, additional, Delcourt, Cécile, additional, Helmer, Catherine, additional, Lamireau, Thierry, additional, Gonzalez, Concepcion, additional, Grouthier, Virginie, additional, Haissaguerre, Magalie, additional, Blanco, Laurence, additional, Alexandre, Laure, additional, Mohammedi, Kamel, additional, and Rigalleau, Vincent, additional

Published
2020
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41. Trajectories of recall memory as predictive of hearing impairment: A longitudinal cohort study

Author

Maharani, Asri, Dawes, Piers, Nazroo, James, Tampubolon, Gindo, Pendleton, Neil, Bertelsen, Geir, Cosh, Suzanne, Cougnard-Grégoire, Audrey, Delcourt, Cécile, Constantinidou, Fofi, Goedegebure, Andre, Helmer, Catherine, Arfan Ikram, M., Klaver, Caroline C.W., Meester-Smoor, Magda, Nael, Virginie, Oosterloo, Neelke, Schirmer, Henrik, Tiemeier, Henning, Otorhinolaryngology and Head and Neck Surgery, Ophthalmology, Epidemiology, and Child and Adolescent Psychiatry / Psychology

Subjects
Male, ResearchInstitutes_Networks_Beacons/global_development_institute, Longitudinal study, Aging, Physiology, Social Sciences, Otology, Audiology, Deafness, Cohort Studies, 0302 clinical medicine, Cognition, Learning and Memory, Hearing, Medicine and Health Sciences, Psychology, Public and Occupational Health, Longitudinal Studies, 030223 otorhinolaryngology, Hearing Disorders, Aged, 80 and over, Cognitive Impairment, Multidisciplinary, VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801, medicine.diagnostic_test, Cognitive Neurology, Hearing Tests, Middle Aged, England, Neurology, Memory Recall, Medicine, Female, Sensory Perception, Anatomy, Cohort study, Research Article, medicine.medical_specialty, Science, Cognitive Neuroscience, 03 medical and health sciences, Memory, medicine, otorhinolaryngologic diseases, Humans, Cognitive Dysfunction, Association (psychology), Hearing Loss, Aged, Memory Disorders, Recall, Biology and Life Sciences, Physical Activity, Global Development Institute, Otorhinolaryngology, Ageing, Ears, Mental Recall, Hearing test, Cognitive Science, VDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801, Physiological Processes, Organism Development, Head, 030217 neurology & neurosurgery, Neuroscience, Developmental Biology
Abstract

Objectives - Accumulating evidence points to a relationship between hearing function and cognitive ability in later life. However, the exact mechanisms of this relationship are still unclear. This study aimed to characterise latent cognitive trajectories in recall memory and identify their association with subsequent risk of hearing impairment. Methods - We analysed data from the English Longitudinal Study of Ageing Wave 1 (2002/03) until Wave 7 (2014/15). The study population consisted of 3,615 adults aged 50+ who participated in the first wave of the English Longitudinal Study of Ageing, who had no self-reported hearing impairment in Wave 1, and who underwent a hearing test in Wave 7. Respondents were classified as having hearing impairment if they failed to hear tones quieter than 35 dB HL in the better ear. Results - The trajectories of recall memory scores were grouped using latent class growth mixture modelling and were related to the presence of hearing impairment in Wave 7. Models estimating 1-class through 5-class recall memory trajectories were compared and the best-fitting models were 4-class trajectories. The different recall memory trajectories represent different starting points and mean of the memory scores. Compared to respondents with the highest recall memory trajectory, other trajectories were increasingly likely to develop later hearing impairment. Conclusions - Long-term changes in cognitive ability predict hearing impairment. Further research is required to identify the mechanisms explaining the association between cognitive trajectories and hearing impairment, as well as to determine whether intervention for maintenance of cognitive function also give benefit on hearing function among older adults.

Published
2019
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42. Mediterranean Diet and Incidence of Advanced Age-Related Macular Degeneration: The EYE-RISK Consortium

Author

Merle, Bénédicte M.J., Colijn, Johanna M., Cougnard-Grégoire, Audrey, de Koning-Backus, Alexandra P.M., Delyfer, Marie Noëlle, Kiefte-de Jong, Jessica C., Meester-Smoor, Magda, Féart, Catherine, Verzijden, Timo, and Samieri, Cécilia

Subjects
Ophthalmology
Abstract

Purpose: To investigate associations of adherence to the Mediterranean diet (MeDi) with incidence of advanced age-related macular degeneration (AMD; the symptomatic form of AMD) in 2 European population-based prospective cohorts. Design: Prospective cohort study of the Rotterdam Study I (RS-I) and the Antioxydants, Lipides Essentiels, Nutrition et Maladies Oculaires (Alienor) Study populations. Participants: Four thousand four hundred forty-six participants 55 years of age or older from the RS-I (The Netherlands) and 550 French adults 73 years of age or older from the Alienor Study with complete ophthalmologic and dietary data were included in the present study. Methods: Examinations were performed approximately every 5 years over a 21-year period (1990–2011) in RS-I and every 2 years over a 4-year period (2006–2012) in the Alienor Study. Adherence to the MeDi was evaluated using a 9-component score based on intake of vegetables, fruits, legumes, cereals, fish, meat, dairy products, alcohol, and the monounsaturated-to-saturated fatty acids ratio. Associations of incidence of AMD with MeDi were estimated using multivariate Cox proportional hazard models. Main Outcomes Measures: Incidence of advanced AMD based on retinal fundus photographs. Results: Among the 4996 included participants, 155 demonstrated advanced incident AMD (117 from the RS-I and 38 from the Alienor Study). The mean follow-up time was 9.9 years (range, 0.6–21.7 years) in the RS-I and 4.1 years (range, 2.5–5.0 years) in the Alienor Study. Pooling data for both the RS-I and Alienor Study, participants with a high (range, 6–9) MeDi score showed a significantly reduced risk for incident advanced AMD compared with participants with a low (range, 0–3) MeDi score in the fully adjusted Cox model (hazard ratio, 0.59; 95% confidence interval, 0.37–0.95; P = 0.04 for trend). Conclusions: Pooling data from the RS-I and Alienor Study, higher adherence to the MeDi was associated with a 41% reduced risk of incident advanced AMD. These findings support the role of a diet rich in healthful nutrient-rich foods such as fruits, vegetables, legumes, and fish in the prevention of AMD.

Published
2019
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43. Increased High-Density Lipoprotein Levels Associated with Age-Related Macular Degeneration: Evidence from the EYE-RISK and European Eye Epidemiology Consortia

Author

Colijn, Johanna M, den Hollander, Anneke I, Demirkan, Ayse, Cougnard-Grégoire, Audrey, Verzijden, Timo, Kersten, Eveline, Meester-Smoor, Magda A, Merle, Benedicte M J, Papageorgiou, Grigorios, Ahmad, Shahzad, Mulder, Monique T, Costa, Miguel Angelo, Benlian, Pascale, Bertelsen, Geir, Bron, Alain M, Claes, Birte, Creuzot-Garcher, Catherine, Erke, Maja Gran, Fauser, Sascha, Foster, Paul J, Hammond, Christopher J, Hense, Hans-Werner, Hoyng, Carel B, Khawaja, Anthony P, Korobelnik, Jean-Francois, Piermarocchi, Stefano, Segato, Tatiana, Silva, Rufino, Souied, Eric H, Williams, Katie M, van Duijn, Cornelia M, Bergen, Arthur, ANS - Complex Trait Genetics, ARD - Amsterdam Reproduction and Development, ANS - Amsterdam Neuroscience, and Human Genetics

Subjects
Aged, 80 and over, Male, Cholesterol, HDL/blood, Magnetic Resonance Spectroscopy, genetic structures, Middle Aged, Lipid Metabolism, Polymorphism, Single Nucleotide, eye diseases, Triglycerides/blood, Cross-Sectional Studies, Cholesterol, LDL/blood, European Continental Ancestry Group/statistics & numerical data, Risk Factors, Cholesterol Ester Transfer Proteins/blood, Odds Ratio, Humans, Metabolomics, lipids (amino acids, peptides, and proteins), Female, sense organs, European Union, Macular Degeneration/blood, Aged
Abstract

PURPOSE: Genetic and epidemiologic studies have shown that lipid genes and high-density lipoproteins (HDLs) are implicated in age-related macular degeneration (AMD). We studied circulating lipid levels in relationship to AMD in a large European dataset. DESIGN: Pooled analysis of cross-sectional data. PARTICIPANTS: Individuals (N = 30 953) aged 50 years or older participating in the European Eye Epidemiology (E3) consortium and 1530 individuals from the Rotterdam Study with lipid subfraction data. METHODS: AMD features were graded on fundus photographs using the Rotterdam classification. Routine blood lipid measurements, genetics, medication, and potential confounders were extracted from the E3 database. In a subgroup of the Rotterdam Study, lipid subfractions were identified by the Nightingale biomarker platform. Random-intercepts mixed-effects models incorporating confounders and study site as a random effect were used to estimate associations. MAIN OUTCOME MEASURES: AMD features and stage; lipid measurements. RESULTS: HDL was associated with an increased risk of AMD (odds ratio [OR], 1.21 per 1-mmol/l increase; 95% confidence interval [CI], 1.14-1.29), whereas triglycerides were associated with a decreased risk (OR, 0.94 per 1-mmol/l increase; 95% CI, 0.91-0.97). Both were associated with drusen size. Higher HDL raised the odds of larger drusen, whereas higher triglycerides decreases the odds. LDL cholesterol reached statistical significance only in the association with early AMD (P = 0.045). Regarding lipid subfractions, the concentration of extra-large HDL particles showed the most prominent association with AMD (OR, 1.24; 95% CI, 1.10-1.40). The cholesteryl ester transfer protein risk variant (rs17231506) for AMD was in line with increased HDL levels (P = 7.7 × 10-7), but lipase C risk variants (rs2043085, rs2070895) were associated in an opposite way (P = 1.0 × 10-6 and P = 1.6 × 10-4). CONCLUSIONS: Our study suggested that HDL cholesterol is associated with increased risk of AMD and that triglycerides are negatively associated. Both show the strongest association with early AMD and drusen. Extra-large HDL subfractions seem to be drivers in the relationship with AMD, and variants in lipid genes play a more ambiguous role in this association. Whether systemic lipids directly influence AMD or represent lipid metabolism in the retina remains to be answered.

Published
2019

44. Mediterranean Diet and Incidence of Advanced Age-Related Macular Degeneration: The EYE-RISK Consortium

Author

Merle, B. nédicte M. J., Colijn, Johanna M., Cougnard-Grégoire, Audrey, de Koning-Backus, Alexandra P. M., Delyfer, Marie-Noëlle, Kiefte-de Jong, Jessica C., Meester-Smoor, Magda, Féart, Catherine, Verzijden, Timo, Samieri, C. cilia, Franco, Oscar H., Korobelnik, Jean-François, Klaver, Caroline C. W., Delcourt, C. cile, Ajana, Soufiane, Arango-Gonzalez, Blanca, Armento, Angela, Arndt, Verena, Bhatia, Vaibhav, Bhattacharya, Shomi S., Biarnés, Marc, Borrell, Anna, Bühren, Sebastian, Calado, Sofia M., Dammeier, Sascha, de Jong, Eiko K., de la Cerda, Berta, den Hollander, Anneke I., Diaz-Corrales, Francisco J., Diether, Sigrid, Emri, Eszter, Endermann, Tanja, Ferraro, Lucia L., Garcia, M. riam, Heesterbeek, Thomas J., Honisch, Sabina, Hoyng, Carel B., Kersten, Eveline, Kilger, Ellen, Langen, Hanno, Lengyel, Imre, Luthert, Phil, Maugeais, Cyrille, van Leeuwen, Elisabeth M., Zumbansen, Markus, Vasiliev, Vassil, Experimental Immunology, and AII - Inflammatory diseases

Abstract

Purpose: To investigate associations of adherence to the Mediterranean diet (MeDi) with incidence of advanced age-related macular degeneration (AMD; the symptomatic form of AMD) in 2 European population-based prospective cohorts. Design: Prospective cohort study of the Rotterdam Study I (RS-I) and the Antioxydants, Lipides Essentiels, Nutrition et Maladies Oculaires (Alienor) Study populations. Participants: Four thousand four hundred forty-six participants 55 years of age or older from the RS-I (The Netherlands) and 550 French adults 73 years of age or older from the Alienor Study with complete ophthalmologic and dietary data were included in the present study. Methods: Examinations were performed approximately every 5 years over a 21-year period (1990–2011) in RS-I and every 2 years over a 4-year period (2006–2012) in the Alienor Study. Adherence to the MeDi was evaluated using a 9-component score based on intake of vegetables, fruits, legumes, cereals, fish, meat, dairy products, alcohol, and the monounsaturated-to-saturated fatty acids ratio. Associations of incidence of AMD with MeDi were estimated using multivariate Cox proportional hazard models. Main Outcomes Measures: Incidence of advanced AMD based on retinal fundus photographs. Results: Among the 4996 included participants, 155 demonstrated advanced incident AMD (117 from the RS-I and 38 from the Alienor Study). The mean follow-up time was 9.9 years (range, 0.6–21.7 years) in the RS-I and 4.1 years (range, 2.5–5.0 years) in the Alienor Study. Pooling data for both the RS-I and Alienor Study, participants with a high (range, 6–9) MeDi score showed a significantly reduced risk for incident advanced AMD compared with participants with a low (range, 0–3) MeDi score in the fully adjusted Cox model (hazard ratio, 0.59; 95% confidence interval, 0.37–0.95; P = 0.04 for trend). Conclusions: Pooling data from the RS-I and Alienor Study, higher adherence to the MeDi was associated with a 41% reduced risk of incident advanced AMD. These findings support the role of a diet rich in healthful nutrient-rich foods such as fruits, vegetables, legumes, and fish in the prevention of AMD.

Published
2019

45. Associations between self-reported sensory impairment and risk of cognitive decline and impairment in the health and retirement study cohort

Author

Maharani, Asri, Dawes, Piers, Nazroo, James, Tampubolon, Gindo, Pendleton, Neil, Bertelsen, Geir, Cosh, Suzanne, Cougnard-Grégoire, Audrey, Delcourt, Cécile, Constantinidou, Fofi, Goedegebure, Andre, Helmer, Catherine, Arfan Ikram, M., Klaver, Caroline C.W., Meester-Smor, Magda, Nael, Virginie, Oosterloo, Neelke, Schirmer, Henrik, Tiemeier, Henning, Maharani, Asri, Dawes, Piers, Nazroo, James, Tampubolon, Gindo, Pendleton, Neil, Bertelsen, Geir, Cosh, Suzanne, Cougnard-Grégoire, Audrey, Delcourt, Cécile, Constantinidou, Fofi, Goedegebure, Andre, Helmer, Catherine, Arfan Ikram, M., Klaver, Caroline C.W., Meester-Smor, Magda, Nael, Virginie, Oosterloo, Neelke, Schirmer, Henrik, and Tiemeier, Henning

Abstract

Objectives: We aimed to determine whether self-assessed single (hearing or visual) and dual sensory (hearing and visual) impairments are associated with cognitive decline and incident possible cognitive impairment, no dementia (CIND) and probable dementia. Method: Data were drawn from the 1996-2014 surveys of the Health and Retirement Study (HRS), involving 19,618 respondents who had no probable dementia and who were aged 50 years or older at the baseline. We used linear mixed models to test the association between self-assessed sensory impairment and cognitive decline followed by a Cox proportional hazard model to estimate the relative risk of incident possible CIND and probable dementia associated with the presence of sensory impairment. Results: Respondents with self-assessed single and dual sensory impairment performed worse in cognitive tests than those without sensory impairment. The fully adjusted incidence of developing possible CIND was 17% higher for respondents with hearing impairment than those without hearing impairment. Respondents with visual impairment had 35% and 25% higher risk for developing possible CIND and probable dementia, respectively, than those without visual impairment. Respondents with dual sensory impairment at baseline were 38% and 26% more likely to develop possible CIND and probable dementia, respectively, than those with no sensory impairment. Discussion: Self-assessed sensory impairment is independently associated with cognitive decline and incident possible CIND and probable dementia. Further studies are needed to identify the mechanism underlying this association and to determine whether treatment of sensory impairment could ameliorate cognitive decline and delay the onset of dementia among older adults.

Published
2020

46. Trajectories of recall memory as predictive of hearing impairment:A longitudinal cohort study

Author

Maharani, Asri, Dawes, Piers, Nazroo, James, Tampubolon, Gindo, Pendleton, Neil, Bertelsen, Geir, Cosh, Suzanne, Cougnard-Grégoire, Audrey, Delcourt, Cécile, Constantinidou, Fofi, Goedegebure, Andre, Helmer, Catherine, Arfan Ikram, M., Klaver, Caroline C.W., Meester-Smoor, Magda, Nael, Virginie, Oosterloo, Neelke, Schirmer, Henrik, Tiemeier, Henning, Maharani, Asri, Dawes, Piers, Nazroo, James, Tampubolon, Gindo, Pendleton, Neil, Bertelsen, Geir, Cosh, Suzanne, Cougnard-Grégoire, Audrey, Delcourt, Cécile, Constantinidou, Fofi, Goedegebure, Andre, Helmer, Catherine, Arfan Ikram, M., Klaver, Caroline C.W., Meester-Smoor, Magda, Nael, Virginie, Oosterloo, Neelke, Schirmer, Henrik, and Tiemeier, Henning

Abstract

Objectives Accumulating evidence points to a relationship between hearing function and cognitive ability in later life. However, the exact mechanisms of this relationship are still unclear. This study aimed to characterise latent cognitive trajectories in recall memory and identify their association with subsequent risk of hearing impairment. Methods We analysed data from the English Longitudinal Study of Ageing Wave 1 (2002/03) until Wave 7 (2014/15). The study population consisted of 3,615 adults aged 50+ who participated in the first wave of the English Longitudinal Study of Ageing, who had no self-reported hearing impairment in Wave 1, and who underwent a hearing test in Wave 7. Respondents were classified as having hearing impairment if they failed to hear tones quieter than 35 dB HL in the better ear. Results The trajectories of recall memory scores were grouped using latent class growth mixture modelling and were related to the presence of hearing impairment in Wave 7. Models estimating 1-class through 5-class recall memory trajectories were compared and the best-fitting models were 4-class trajectories. The different recall memory trajectories represent different starting points and mean of the memory scores. Compared to respondents with the highest recall memory trajectory, other trajectories were increasingly likely to develop later hearing impairment. Conclusions Long-term changes in cognitive ability predict hearing impairment. Further research is required to identify the mechanisms explaining the association between cognitive trajectories and hearing impairment, as well as to determine whether intervention for maintenance of cognitive function also give benefit on hearing function among older adults.

Published
2020

47. Metabolomics in serum of patients with non-advanced age-related macular degeneration reveals aberrations in the glutamine pathway

Author

Kersten, Eveline, Dammeier, Sascha, Ajana, Soufiane, Groenewoud, Joannes M.M., Codrea, Marius, Klose, Franziska, Lechanteur, Yara T., Fauser, Sascha, Ueffing, Marius, Delcourt, Cécile, Hoyng, Carel B., de Jong, Eiko, Den Hollander, Anneke I., Arango-Gonzalez, Blanca, Arndt, Verena, Bhatia, Vaibhav, Bhatta-Charya, Shomi S., Biarnés, Marc, Borrell, Anna, Bühren, Sebastian, Calado, Sofia M., Colijn, Johanna M., Cougnard-Grégoire, Audrey, De la Cerda, Berta, Del-Court, Cécile, Diaz-Corrales, F. J., Diether, Sigrid, Emri, Eszter, Ender-Mann, Tanja, Ferraro, Lucia, Garcia, Míriam, Heesterbeek, Thomas J., Honisch, Sabina, Iacone, Roberto, Kilger, Ellen, Klaver, Caroline C.W., Langen, Hanno, Lengyel, Imre, Luthert, Phil, Maugeais, Cyrille, Meester-Smoor, Magda, Merle, Benedicte, Monés, Jordi, Nogoceke, Everson, Peto, Tunde, Pool, Fran, Rodríguez, Eduardo, Bartz-Schmidt, Karl Ulrich, Verzijden, Timo, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Ophthalmology, and Epidemiology

Subjects
0301 basic medicine, genetic structures, Metabolite, Glutamine, Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13], Disease, Bioinformatics, Biochemistry, Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12], chemistry.chemical_compound, Macular Degeneration, 0302 clinical medicine, Medicine and Health Sciences, Metabolites, Geriatric Ophthalmology, Amino Acids, Multidisciplinary, Agricultural and Biological Sciences(all), Organic Compounds, Retinal Degeneration, Acidic Amino Acids, Discriminant Analysis, Neurochemistry, Neurotransmitters, Middle Aged, 3. Good health, Chemistry, Physical Sciences, Biomarker (medicine), Medicine, Retinal Disorders, Female, Metabolic Pathways, Glutamate, Metabolic Networks and Pathways, Research Article, Science, 03 medical and health sciences, Metabolomics, Age related, medicine, Humans, Least-Squares Analysis, General, Nutrition, Aged, Glutaminolysis, business.industry, Biochemistry, Genetics and Molecular Biology(all), Organic Chemistry, Chemical Compounds, Biology and Life Sciences, Proteins, Macular degeneration, medicine.disease, eye diseases, Diet, Ophthalmology, 030104 developmental biology, Metabolism, chemistry, Geriatrics, Macular Disorders, 030221 ophthalmology & optometry, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, sense organs, business, Biomarkers, Neuroscience
Abstract

Contains fulltext : 205500.pdf (Publisher’s version ) (Open Access) Age-related macular degeneration (AMD) is a common, progressive multifactorial vision-threatening disease and many genetic and environmental risk factors have been identified. The risk of AMD is influenced by lifestyle and diet, which may be reflected by an altered metabolic profile. Therefore, measurements of metabolites could identify biomarkers for AMD, and could aid in identifying high-risk individuals. Hypothesis-free technologies such as metabolomics have a great potential to uncover biomarkers or pathways that contribute to disease pathophysiology. To date, only a limited number of metabolomic studies have been performed in AMD. Here, we aim to contribute to the discovery of novel biomarkers and metabolic pathways for AMD using a targeted metabolomics approach of 188 metabolites. This study focuses on non-advanced AMD, since there is a need for biomarkers for the early stages of disease before severe visual loss has occurred. Targeted metabolomics was performed in 72 patients with early or intermediate AMD and 72 control individuals, and metabolites predictive for AMD were identified by a sparse partial least squares discriminant analysis. In our cohort, we identified four metabolite variables that were most predictive for early and intermediate stages of AMD. Increased glutamine and phosphatidylcholine diacyl C28:1 levels were detected in non-advanced AMD cases compared to controls, while the rate of glutaminolysis and the glutamine to glutamate ratio were reduced in non-advanced AMD. The association of glutamine with non-advanced AMD corroborates a recent report demonstrating an elevated glutamine level in early AMD using a different metabolomics technique. In conclusion, this study indicates that metabolomics is a suitable method for the discovery of biomarker candidates for AMD. In the future, larger metabolomics studies could add to the discovery of novel biomarkers in yet unknown AMD pathways and expand our insights in AMD pathophysiology.

Published
2019
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49. Mediterranean Diet and Incidence of Advanced Age-Related Macular Degeneration: The EYE-RISK Consortium

Author

Merle, Bénédicte M. J., Colijn, Johanna M., Cougnard-Grégoire, Audrey, Koning-Backus, Alexandra de, Delyfer, Marie Nöelle, Kiefte-de Jong, Jessica, Meester-Smoor, Magda, Féart, Catherine, Verzijden, Timo, Samieri, Cécilia, Franco, Oscar H., Korobelnik, Jean-François, Klaver, Caroline C. W., Delcourt, Cécilia, EYE-RISK Consortium, Laboratoires Théa, Nestlé, Essilor, Bayer, Alcon, IVERIC bio, Notal Vision, Novartis, Roche, Optos, European Commission, Erasmus University Rotterdam, Netherlands Organisation for Health Research and Development, Ministry of Education, Culture and Science (The Netherlands), Ministry of Health, Welfare and Sport (The Netherlands), Fondation Voir et Entendre, Retina France, and Agence Nationale de la Recherche (France)

Subjects
Aged, 80 and over, Male, Incidence, Middle Aged, Diet, Mediterranean, Diet Records, White People, Macular Degeneration, Risk Factors, Humans, Female, France, Prospective Studies, Aged, Netherlands, Proportional Hazards Models
Abstract

Purpose: To investigate associations of adherence to the Mediterranean diet (MeDi) with incidence of advanced age-related macular degeneration (AMD; the symptomatic form of AMD) in 2 European population-based prospective cohorts. Design: Prospective cohort study of the Rotterdam Study I (RS-I) and the Antioxydants, Lipides Essentiels, Nutrition et Maladies Oculaires (Alienor) Study populations. Participants: Four thousand four hundred forty-six participants 55 years of age or older from the RS-I (The Netherlands) and 550 French adults 73 years of age or older from the Alienor Study with complete ophthalmologic and dietary data were included in the present study. Methods: Examinations were performed approximately every 5 years over a 21-year period (1990–2011) in RS-I and every 2 years over a 4-year period (2006–2012) in the Alienor Study. Adherence to the MeDi was evaluated using a 9-component score based on intake of vegetables, fruits, legumes, cereals, fish, meat, dairy products, alcohol, and the monounsaturated-to-saturated fatty acids ratio. Associations of incidence of AMD with MeDi were estimated using multivariate Cox proportional hazard models. Main Outcomes Measures: Incidence of advanced AMD based on retinal fundus photographs. Results: Among the 4996 included participants, 155 demonstrated advanced incident AMD (117 from the RS-I and 38 from the Alienor Study). The mean follow-up time was 9.9 years (range, 0.6–21.7 years) in the RS-I and 4.1 years (range, 2.5–5.0 years) in the Alienor Study. Pooling data for both the RS-I and Alienor Study, participants with a high (range, 6–9) MeDi score showed a significantly reduced risk for incident advanced AMD compared with participants with a low (range, 0–3) MeDi score in the fully adjusted Cox model (hazard ratio, 0.59; 95% confidence interval, 0.37–0.95; P = 0.04 for trend). Conclusions: Pooling data from the RS-I and Alienor Study, higher adherence to the MeDi was associated with a 41% reduced risk of incident advanced AMD. These findings support the role of a diet rich in healthful nutrient-rich foods such as fruits, vegetables, legumes, and fish in the prevention of AMD., The author(s) have made the following disclosure(s): B.M.J.M.: Consultant e Bausch & Lomb (Rochester, New York); Financial support e Laboratoires Théa (Clermont-Ferrand, France). A.C.-G.: Financial support e Laboratoires Théa (Clermont-Ferrand, France). M.-N.D.: Consultant e Bayer (Leverkusen, Germany), Allergan (Irvine, California), Novartis (Basel, Switzerland); Board membership e Bayer (Leverkusen, Germany), Allergan (Irvine, California), Novartis (Basel, Switzerland). O.H.F.: Financial support e Nestle (Vevey, Switzerland). J.-F.K.: Consultant e Alcon (Hünenberg, Switzerland), Alimera (Alpharetta, Georgia), Novartis (Basel, Switzerland), Roche (Basel, Switzerland), Thea (Clermont-Ferrand, France), Zeiss (Oberkochen, Germany), Bayer (Leverkusen, Germany). C.C.W.K.: Consultant e Bayer (Leverkusen, Germany); Lecturer e Novartis (Basel, Switzerland), Thea Pharma (Clermont-Ferrand, France). C.D.: Consultant e Allergan (Irvine, California), Bausch & Lomb (Rochester, New York), Laboratoires Théa (Clermont-Ferrand, France), Novartis (Basel, Switzerland), Roche (Basel, Switzerland); Financial support e Laboratoires Théa (Clermont-Ferrand, France), Essilor (Charenton le Pont, France). M.B.: Travel fees e Bayer (Leverkusen, Germany); Consultant e Roche (Basel, Switzerland). R.I., H.L., C.M., and E.N.: Employees e F. Hoffmann-La Roche Ltd (Basel, Switzerland). J.M.: Financial support e Bayer (Leverkusen, Germany), Alcon (Hünenberg, Switzerland), Ophthotech (New-York, NY), Notal Vision (Manassas, VA), Novartis (Basel, Switzerland), Roche (Basel, Switzerland). I.L.: Unrestricted research support e OPTOS Plc (Dunfermline, UK). Competing financial interest of members of the EYE-RISK consortium not otherwise disclosed: Verena Arndt, Sebastian Bühren, Tanja Endermann, and Markus Zumbansen are employees of AYOXXA. The EYE-RISK project is supported by the European Union’s Horizon 2020 Research and Innovation Programme (grant no.: 634479). The Rotterdam Study is funded by Erasmus Medical Center and Erasmus University, Rotterdam, The Netherlands; the Organization for the Health Research and Development (ZonMw); the Research Institute for Diseases in the Elderly (RIDE); the Ministry of Education, Culture and Science; the Ministry for Health, Welfare and Sports; the European Commission (DG XII), and the Municipality of Rotterdam, Rotterdam, The Netherlands. Additionally, the ophthalmic research within the Rotterdam Study was supported by the following foundations: Oogfonds; Bartiméus Sonneheerdt Vereniging; Landelijke Stichting voor Blinden en Slechtzienden; Algemene Nederlandse Vereniging Ter Voorkoming Van Blindheid; Novartis Foundation; and MaculaFonds, which contributed through UitZicht (grant nos.: 2015-36 and 2016-19). The funding organizations had no role in the design or conduct of this research and provided unrestricted grants. The Antioxydants, Lipides Essentiels, Nutrition et Maladies Oculaires Study is funded by Laboratoires Théa; Fondation Voir et Entendre; Retina France; Agence Nationale de la Recherche (ANR 2010-PRSP-011 VISA); and Caisse Nationale pour la Solidarité et l’Autonomie.

Published
2018

50. Associations Between Self-Reported Sensory Impairment and Risk of Cognitive Decline and Impairment in the Health and Retirement Study Cohort

Author

Maharani, Asri, Dawes, Piers, Nazroo, James, Tampubolon, Gindo, Pendleton, Neil, Bertelsen, Geir, Cosh, Suzanne, Cougnard-Grégoire, Audrey, Delcourt, Cécile, Constantinidou, Fofi, Goedegebure, Andre, Helmer, Catherine, Ikram, M Arfan, Klaver, Caroline C W, Leroi, Iracema, Meester-Smor, Magda, Nael, Virginie, Oosterloo, Neelke, Schirmer, Henrik, Tiemeier, Henning, von Hanno, Therese, Constantinidou, Fofi [0000-0002-7928-8363], Dawes, Piers [0000-0003-3180-9884], Maharani, Asri [0000-0002-5931-8692], Tampubolon, Gindo [0000-0002-9081-2349], Otorhinolaryngology and Head and Neck Surgery, Ophthalmology, Epidemiology, and Child and Adolescent Psychiatry / Psychology

Subjects
Male, ResearchInstitutes_Networks_Beacons/global_development_institute, medicine.medical_specialty, Social Psychology, Hearing loss, Visual impairment, Vision Disorders, Audiology, Cohort Studies, 03 medical and health sciences, Diagnostic Self Evaluation, 0302 clinical medicine, Risk Factors, mental disorders, Medicine, Dementia, Humans, Cognitive Dysfunction, 030212 general & internal medicine, Longitudinal Studies, Cognitive decline, Correlation of Data, Hearing Loss, Aged, Retirement, business.industry, Proportional hazards model, Incidence, Middle Aged, medicine.disease, Mental Status and Dementia Tests, Cognitive test, Clinical Psychology, Global Development Institute, Relative risk, Cohort, Female, Geriatrics and Gerontology, medicine.symptom, business, Gerontology, 030217 neurology & neurosurgery
Abstract

Objectives We aimed to determine whether self-assessed single (hearing or visual) and dual sensory (hearing and visual) impairments are associated with cognitive decline and incident possible cognitive impairment, no dementia (CIND) and probable dementia. Method Data were drawn from the 1996–2014 surveys of the Health and Retirement Study (HRS), involving 19,618 respondents who had no probable dementia and who were aged 50 years or older at the baseline. We used linear mixed models to test the association between self-assessed sensory impairment and cognitive decline followed by a Cox proportional hazard model to estimate the relative risk of incident possible CIND and probable dementia associated with the presence of sensory impairment. Results Respondents with self-assessed single and dual sensory impairment performed worse in cognitive tests than those without sensory impairment. The fully adjusted incidence of developing possible CIND was 17% higher for respondents with hearing impairment than those without hearing impairment. Respondents with visual impairment had 35% and 25% higher risk for developing possible CIND and probable dementia, respectively, than those without visual impairment. Respondents with dual sensory impairment at baseline were 38% and 26% more likely to develop possible CIND and probable dementia, respectively, than those with no sensory impairment. Discussion Self-assessed sensory impairment is independently associated with cognitive decline and incident possible CIND and probable dementia. Further studies are needed to identify the mechanism underlying this association and to determine whether treatment of sensory impairment could ameliorate cognitive decline and delay the onset of dementia among older adults.

Published
2018
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