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1. Comparison of fludarabine/melphalan (FluMel) with fludarabine/melphalan/BCNU or thiotepa (FBM/FTM) in patients with AML in first complete remission undergoing allogeneic hematopoietic stem cell transplantation – a registry study on behalf of the EBMT Acute Leukemia Working Party

Author

Duque-Afonso, Jesús, Finke, Jürgen, Ngoya, Maud, Galimard, Jacques-Emmanuel, Craddock, Charles, Raj, Kavita, Bloor, Adrian, Nicholson, Emma, Eder, Matthias, Kim, Orchard, Valerius, Thomas, Snowden, John A., Tholouli, Eleni, Crawley, Charles, Collin, Matthew, Wilson, Keith M. O., Gadisseur, Alain, Protheroe, Rachel, Wagner-Drouet, Eva Maria, Savani, Bipin N., Spyridonidis, Alexandros, Ciceri, Fabio, Nagler, Arnon, and Mohty, Mohamad

Published
2024
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2. Posttransplant MRD and T-cell chimerism status predict outcomes in patients who received allografts for AML/MDS

Author

Loke, Justin, McCarthy, Nicholas, Jackson, Aimee, Siddique, Shamyla, Hodgkinson, Andrea, Mason, John, Crawley, Charles, Gilleece, Maria, Peniket, Andrew, Protheroe, Rachel, Salim, Rahuman, Tholouli, Eleni, Wilson, Keith, Andrew, Georgia, Dillon, Richard, Khan, Naeem, Potter, Victoria, Krishnamurthy, Pramila, Craddock, Charles, and Freeman, Sylvie

Published
2023
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3. HLA Mismatching and Transplant Outcome in the Ptcy Era: A Comprehensive Study By the EBMT Cellular Therapy and Immunobiology Working Party

Author

Bolaños, Esteban Arrieta, primary, Bonneville, Edouard F, additional, Robin, Marie, additional, Gedde-Dahl, Tobias, additional, Salmenniemi, Urpu, additional, Kröger, Nicolaus, additional, Yakoub-Agha, Ibrahim, additional, Crawley, Charles, additional, Choi, Goda, additional, Broers, Annoek EC, additional, Forcade, Edouard, additional, Carre, Martin, additional, Poiré, Xavier, additional, Huynh, Anne, additional, Remenyi, Peter, additional, Lenhoff, Stig, additional, Ciceri, Fabio, additional, Tholouli, Eleni, additional, Schroeder, Thomas, additional, Deconinck, Eric, additional, Carlson, Kristina Elisabet, additional, de Wreede, Liesbeth C, additional, Hoogenboom, Jorinde, additional, Malard, Florent, additional, Ruggeri, Annalisa, additional, and Fleischhauer, Katharina, additional

Published
2024
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4. Autologous hematopoietic cell transplantation for relapsed multiple myeloma performed with cells procured after previous transplantation–study on behalf of CMWP of the EBMT

Author

Drozd-Sokołowska, Joanna, Gras, Luuk, Zinger, Nienke, Snowden, John A., Arat, Mutlu, Basak, Grzegorz, Pouli, Anastasia, Crawley, Charles, Wilson, Keith M. O., Tilly, Herve, Byrne, Jennifer, Bulabois, Claude Eric, Passweg, Jakob, Ozkurt, Zubeyde Nur, Schroyens, Wilfried, Lioure, Bruno, Colorado Araujo, Mercedes, Poiré, Xavier, Van Gorkom, Gwendolyn, Gurman, Gunhan, de Wreede, Liesbeth C., Hayden, Patrick J., Beksac, Meral, Schönland, Stefan O., and Yakoub-Agha, Ibrahim

Published
2022
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5. Influence of pretransplant inflammatory bowel disease on the outcome of allogeneic hematopoietic stem cell transplantation: a matched-pair analysis study from the Transplant Complications Working Party (TCWP) of the EBMT

Author

Peric, Zinaida, Peczynski, Christophe, Polge, Emmanuelle, Kröger, Nicolaus, Sengeloev, Henrik, Radujkovic, Aleksandar, Helbig, Grzegorz, Russell, Nigel, Bunjes, Donald, Socié, Gerard, Potter, Victoria, Beelen, Dietrich, Crawley, Charles, Bloor, Adrian, Finke, Jürgen, Schoemans, Helene, Penack, Olaf, Snowden, John A., Koenecke, Christian, and Basak, Grzegorz W.

Published
2021
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6. Real‐world efficacy of single‐agent belantamab mafodotin in relapsed systemic AL amyloidosis.

Author

Khwaja, Jahanzaib, Bomsztyk, Joshua, Atta, Maria, Bygrave, Ceri, Forbes, Adam, Durairaj, Senthil, Fernandes, Savio, Taylor, James, Paterson, Pamela, Brearton, Gillian, Crawley, Charles, Sheehy, Oonagh, Brown, Rachel, Soutar, Richard, Garg, Mamta, Rydzewski, Andrzej, Jamroziak, Krzysztof, Mahmood, Shameem, and Wechalekar, Ashutosh D.

Subjects
PLASMA cell diseases, AMYLOIDOSIS, ANTIBODY-drug conjugates
Abstract

Summary: Systemic light chain (AL) amyloidosis is a relapsing plasma cell disorder. Therapy is limited, particularly for triple‐class refractory disease. We report the use of belantamab mafodotin, a BCMA‐directed drug–antibody conjugate, for relapsed AL amyloidosis, including patients traditionally excluded from clinical trials. Thirty‐one patients were reviewed, with a median of three prior lines of therapy. The median follow‐up was 12 months (95% CI 4–19), and a median of five doses were delivered. The best haematological overall response rate was 71%, and the complete/very good partial response was 58%. Sixty‐eight percent had keratopathy and improved in all. Belantamab mafodotin has high efficacy and good tolerability in patients with relapsed AL amyloidosis. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Legionellosis after hematopoietic stem cell transplantation

Author

Mikulska, Malgorzata, Tridello, Gloria, Hoek, Jennifer, Gil, Lidia, Yañez, Lucrecia, Labussière-Wallet, Hélène, Passweg, Jakob, Xhaard, Aliénor, Pioltelli, Pietro, Caillot, Denis, Michel, Gerard, Veelken, Hendrik, Blaise, Didier, Bruno, Benedetto, Garcia, Carmen Botella, Itälä-Remes, Maija, Crawley, Charles, Bourhis, Jean Henri, Kaare, Ain, Arcese, William, Parody, Rocio, and Styczynski, Jan

Published
2021
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8. Autologous stem cell transplantation for post-transplant lymphoproliferative disorders after solid organ transplantation: a retrospective analysis from the Lymphoma Working Party of the EBMT

Author

Eyre, Toby A., Caillard, Sophie, Finel, Herve, Boumendil, Ariane, Kothari, Jaimal, Zimmermann, Heiner, Trappe, Ralf Ulrich, De Wilde, Virginie, Tholouli, Eleni, Kanfer, Edward, Broom, Angus, Damaj, Gandhi, Bargetzi, Mario, Kozák, Tomáš, Hilgendorf, Inken, Crawley, Charles, Kerre, Tessa, Trněný, Marek, Bachy, Emmanuel, Robinson, Stephen, and Montoto, Silvia

Published
2021
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9. Fludarabine, Cytarabine, Granulocyte Colony-Stimulating Factor, and Idarubicin With Gemtuzumab Ozogamicin Improves Event-Free Survival in Younger Patients With Newly Diagnosed AML and Overall Survival in Patients With NPM1 and FLT3 Mutations

Author

Russell, Nigel H., primary, Wilhelm-Benartzi, Charlotte, additional, Othman, Jad, additional, Dillon, Richard, additional, Knapper, Steven, additional, Batten, Leona M., additional, Canham, Joanna, additional, Hinson, Emily L., additional, Betteridge, Sophie, additional, Overgaard, Ulrik Malthe, additional, Gilkes, Amanda, additional, Potter, Nicola, additional, Mehta, Priyanka, additional, Kottaridis, Panagiotis, additional, Cavenagh, Jamie, additional, Hemmaway, Claire, additional, Arnold, Claire, additional, Freeman, Sylvie D., additional, Dennis, Mike, additional, Kallenbach, Maria, additional, Severinsen, Marianne, additional, Holm, Mette, additional, Maxwell Norgaard, Jan, additional, Beier Ommen, Hans, additional, Culligan, Dominic, additional, Tighe, Jane, additional, Craig, Jenny, additional, Crawley, Charles, additional, Krishnamurthy, Pramila, additional, Sadik, Walid, additional, Smith, Jeffery, additional, Dasgupta, Ranjit, additional, Berkhan, Leanne, additional, Bowett, Peter, additional, Doocey, Richard, additional, Emmett, Shannon, additional, Hawkins, Timothy, additional, Patton, Nigel, additional, Pemberton, Lucy, additional, Milne, Alison, additional, Roy, Ashok, additional, Simpson, Sylwia, additional, Cuthbert, Robert, additional, Finnegan, Damian, additional, Francis McMullin, Mary, additional, Pechey, Victoria, additional, Lovell, Richard, additional, Milligan, Donald, additional, Paneesha, Shankara, additional, Cahalin, Paul, additional, Kelsey, P., additional, Ackroyd, Sam, additional, Wiliams, Adrian, additional, Evely, Roger, additional, Marks, David, additional, Fletcher, Andrew, additional, Al-Ani, Maryam, additional, Ahmed, Khalil, additional, Lush, Richard, additional, Rye, Adam, additional, Cutting, Robert, additional, Welch, Emma, additional, Wodzinski, Mark, additional, Butler, Andrew, additional, Fernyhough, Liam, additional, Ganly, Peter, additional, Gibbons, Steve, additional, Smith, Mark, additional, Spearing, Ruth, additional, Peniket, Andy, additional, Hatcliffe, Faye, additional, Patel, Amit, additional, Lindsay, Kathrine, additional, Brearton, Gillian, additional, Tuegar, Salah, additional, Gandhi Anna Cowley, S., additional, Copplestone, Adrian, additional, Hunter, Hannah, additional, Medd, Patrick, additional, Nokes, Tim, additional, Rule, Simon, additional, Thomas, Wayne, additional, Joseph, Joe, additional, Kaul, Stuti, additional, Sorour, Youssef, additional, Chvuka, Shingi, additional, Mangos, Hilda, additional, Neylon, Annette, additional, Farrell, Katrina, additional, Edwards, Hugh, additional, Hanlon, Katharine, additional, Fail, Tom, additional, Goodrick, Margaret, additional, Heartin, Earnest, additional, Hoyle, Christine, additional, Carr, Robert, additional, Raj, Kavita, additional, Krogh Jensen, Morten, additional, Janmohamed, Riaz, additional, Kaczmarski, Richard, additional, Sugai, Taku, additional, Ademokun, Debo, additional, Chalmers, Isobel, additional, Hodson, Andrew, additional, Gomez, Cesar, additional, Sadullah, Shala, additional, Kwan, Mark, additional, Longmuir, Karyn, additional, Wilson-Morkeh, Isaac, additional, Hunter, Ann, additional, Martin, Murray, additional, Saravanamuttu, Kandeepan, additional, Sidra, Gamal, additional, Burns, Sarah, additional, Gibbs, Simon, additional, Tholouli, Eleni, additional, Aldouri, Maadh, additional, Andrews, Vivienne, additional, Eden, Ayed, additional, Dungarwalla, Moez, additional, White, Denise, additional, Laird, Jane, additional, Mitchell, Lindsey, additional, Murphy, John, additional, Paterson, Pamela, additional, Raafat, Alaeddin, additional, Mannari, Deepak, additional, Davies, Simon, additional, Austen, Belinda, additional, Allford, Sarah, additional, Kakalamudi, Sudhakar, additional, Basu, Supratik, additional, Hada, Sunil, additional, Jacob, Abraham, additional, MacWhonell, Alan, additional, McCaig, Alison, additional, Gelly, Keith, additional, Kerr, Ron, additional, Meiklejohn, David, additional, Tauro, Sudhir, additional, Lawes, Matthew, additional, Bowen, Angela, additional, Krishnamurthy, Suchitra, additional, Byrne, Jenny, additional, Dasgupta, Emma, additional, Russell, Nigel, additional, Stokley, Simone, additional, Friis, Lone, additional, Marcher, Claus, additional, Bake, Bart, additional, Chapple, Mary, additional, Moreton, Paul, additional, Omran, Asad, additional, Patil, Kavita, additional, Wright, David, additional, Jack, Fergus, additional, Maddams, Rebecca, additional, Corser, Robert, additional, Cranfield, Tanya, additional, Dignum, Helen, additional, Ganczakowski, Mary, additional, Jones, Christopher, additional, Craddock, Charles, additional, Moss, Paula, additional, Murray, Jim, additional, Craig, Joanne, additional, Forsyth, Peter, additional, Lush, Chris, additional, Wei Bjerrum, Ole, additional, Borregaard, Niels, additional, Kampmann, Peter, additional, Kjeldsen, Lars, additional, Juul Nielsen, Ove, additional, Niemann, Carsten, additional, Lykke Petersen, Soeren, additional, Udby Peter Møller, Lene, additional, Alfred, Arun, additional, Barker, Helen, additional, Went, Richard, additional, Groch, Henri, additional, Mucklow, Stuart, additional, Sampson, Rebecca, additional, Chacko, Joseph, additional, Hall, Rachel, additional, Walewska, Renata, additional, Creach, Desmond, additional, Pottinger, Bryson, additional, Addada, Juanah (Jo), additional, Hamilton, Malcolm, additional, Kerr, Paul, additional, Ngu, Loretta, additional, Rudin, Claudius, additional, Ruell, Jackie, additional, Dalley, Chris, additional, Kaur, Harpreet, additional, Reilly, John, additional, Snowden, John, additional, Ferguson, Paul, additional, Dyer, Peter, additional, Chandra, Deepak, additional, DeVos, Johannes, additional, Grey-Davies, Elisabeth, additional, Hendry, Louise, additional, Corbett, Timothy, additional, Crowe, Josephine, additional, Knechtli, Christopher, additional, Wexler, Sarah, additional, Fernandes, Savio, additional, Neilson, Jeff, additional, Houghton, John, additional, Jowitt, Simon, additional, Thomas-Dewing, Rowena, additional, Williams, Mark, additional, Zaman, Sonya, additional, Cullis, Jonathan, additional, Everington, Tamara, additional, Grand, Effie, additional, Hasan, Yasmin, additional, Murrin, Richard, additional, Wandoo, Farooq, additional, Ismail, Saad, additional, Mohite, Unmesh, additional, Sati, Hamdi, additional, Jenner, Matthew, additional, Orchard, Kim, additional, Richardson, Deborah, additional, McCloskey, Kayleigh, additional, Xu Chin, Kate, additional, Fenella Willis, Neoh, additional, Sud, Amit, additional, Gharib, Maged, additional, Nicholson, Toby, additional, Bowen, David, additional, Janes, Sarah, additional, Eagleton, Helen, additional, O'Hea, Anne-Marie, additional, Pattinson, Jonathan, additional, Hervey, Victoria, additional, Lyons, Simon, additional, Marshall, Scott, additional, Nicolle, Annette, additional, Vavyla, Maria, additional, Burgess, Jordan, additional, Somervaille, Tim, additional, Somerfield, Sven, additional, Mamat, Mohd, additional, Tomlins, Jo, additional, Salesh, Sana, additional, David, Marianna, additional, Maddox, Jamie, additional, Plews, Diane, additional, Dang, Ray, additional, Potter, Mike, additional, Ellis, Lauren, additional, Nicholson, Emma, additional, Keat, Sally, additional, Ahmed Alhassani, Thubeena M., additional, Anjum, Farahn, additional, Chatterjee, Poulami, additional, Stanchev, Atanas, additional, Peters, Jayne, additional, Lindsay-Holmes Srividhya, Sarah, additional, Chodhouri, Senthil S., additional, Eve, Heather, additional, Smith, Steve, additional, Roberts, Patrick, additional, Rymes, Nicholas, additional, Zhao New Oo, Rui, additional, Ardeshna, Kirit, additional, Blombery, Piers, additional, Khwaja, Asim, additional, Linch, David, additional, Popat, Rakesh, additional, Virchis, Andres, additional, Yong, Kwee, additional, McIntyre, Victoria, additional, Horne, Gillian, additional, Bokhari, Syed, additional, Borg, Anton, additional, Chapman, Oliver, additional, Harrison, Beth, additional, Jackson, Nicholas, additional, Jobanputra, Shailesh, additional, Narayanan, Mekkali, additional, Rose, Peter, additional, Oun, Hajer, additional, Powell, Matthew, additional, Gilles, Julie, additional, Laing, Alison, additional, Devanny, Ian, additional, Haskins, Lea, additional, Micallef-Eynaud, Paul, additional, Maclean, Peter, additional, Alvares, Caroline, additional, Kell, Jonathan, additional, Knapper, Steve, additional, Davidson, Kerri, additional, McLintock, Lorna, additional, Rogers, Stephen, additional, Williamson, Peter, additional, Corbett, Gillian, additional, Goodman, Hugh, additional, Islam, Shahid, additional, Pullon, Humphrey, additional, Johnson, Peter, additional, Roddie, P.H., additional, Maughan, Elizabeth, additional, Mills, Juliet, additional, Shafeek, Salim, additional, Narat, Santosh, additional, Aitchison, Robin, additional, Bond, Lee, additional, Munro, Laura, additional, and Edwards, David, additional

Published
2024
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10. Comparison of fludarabine/melphalan (FluMel) with fludarabine/melphalan/BCNU or thiotepa (FBM/FTM) in patients with AML in first complete remission undergoing allogeneic hematopoietic stem cell transplantation – a registry study on behalf of the EBMT Acute Leukemia Working Party

Author

Duque-Afonso, Jesús, primary, Finke, Jürgen, additional, Ngoya, Maud, additional, Galimard, Jacques-Emmanuel, additional, Craddock, Charles, additional, Raj, Kavita, additional, Bloor, Adrian, additional, Nicholson, Emma, additional, Eder, Matthias, additional, Kim, Orchard, additional, Valerius, Thomas, additional, Snowden, John A., additional, Tholouli, Eleni, additional, Crawley, Charles, additional, Collin, Matthew, additional, Wilson, Keith M. O., additional, Gadisseur, Alain, additional, Protheroe, Rachel, additional, Wagner-Drouet, Eva Maria, additional, Savani, Bipin N., additional, Spyridonidis, Alexandros, additional, Ciceri, Fabio, additional, Nagler, Arnon, additional, and Mohty, Mohamad, additional

Published
2023
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12. Role of HLA-B exon 1 in graft-versus-host disease after unrelated haemopoietic cell transplantation: a retrospective cohort study

Author

Petersdorf, Effie W, Carrington, Mary, O'hUigin, Colm, Bengtsson, Mats, De Santis, Dianne, Dubois, Valerie, Gooley, Ted, Horowitz, Mary, Hsu, Katharine, Madrigal, J Alejandro, Maiers, Martin, Malkki, Mari, McKallor, Caroline, Morishima, Yasuo, Oudshoorn, Machteld, Spellman, Stephen, Villard, Jean, Stevenson, Phil, Apperley, Jane, Bardy, Peter, Bernard, Ghislaine, Bertrand, Yves, Bloor, Adrian, Bonini, Chiara, Buhler, Stephane, Bungener, Laura, Campbell, Helen, Carlson, Kristina, Carpenter, Ben, Cesbron, Anne, Chabannon, Christian, Chalandon, Yves, Chapman, Jeremy, Chebel, Réda, Chevallier, Patrice, Choi, Gerda, Collin, Matt, Cornelissen, Jan J, Crawley, Charles, D'Orsogna, Lloyd, Dalle, Jean-Hugues, Deconinck, Eric, DeMatteis, Muriel, Diviney, Mary, Dormoy, Anne, Gagne, Katia, Gibson, Brenda, Gilleece, Maria, Gottlieb, David, Gribben, John, Güngör, Tayfun, Haagenson, Mike, Hart, Cathie, Holdsworth, Rhonda, Humphreys, Ian, Kodera, Yoshihisa, Koh, Mickey, Labussière-Wallet, Hélène, Lankester, Arjan C, Lardy, Neubery, Lawson, Sarah, Leleu, Xavier, MacKinnon, Stephen, Malladi, Ram, Marsh, Steven GE, Martin, Murray, Mayor, Neema P, McQuaker, I Grant, Meijer, Ellen, Morishima, Satoko, Nikolousis, Emmanouil, Orchard, Kim, Passweg, Jacob, Patel, Amit, Patrick, Katherine, Pedron, Béatrice, Peniket, Andy, Perry, Julia, Petersen, Eefke, Potter, Victoria, Potter, Mike, Protheroe, Rachel, Raus, Nicole, Ruiz de Elvira, Carmen, Russell, Nigel, Schaap, Nicholaas PM, Schanz, Urs, Schouten, Harry, Skinner, Roderick, Snowden, John, Spierings, Eric, Steward, Colin, Tholouli, Eleni, Thornton, Alycia, Tilanus, Marcel, van de Meer, Arnold, Veelkens, Hendrik, Veys, Paul, Watson, Narelle, Weston, Lyanne, Wilson, Keith, Wilson, Marie, Wynn, Robert, Zsiros, József, Maiers, Martin J, and Spellman, Stephen R

Published
2020
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13. Molecular MRD is strongly prognostic in patients with NPM1-mutated AML receiving venetoclax-based non-intensive therapy

Author

Othman, Jad, primary, Tiong, Ing Soo, additional, O'Nions, Jenny, additional, Dennis, Mike, additional, Mokretar, Katya, additional, Ivey, Adam, additional, Austin, Michael James, additional, Latif, Annie-Louise, additional, Amer, Mariam, additional, Chan, Wei Yee, additional, Crawley, Charles R, additional, Crolla, Francesca, additional, Cross, Joe Wilson, additional, Dang, Raymond, additional, Elliot, Johnathon, additional, Fong, Chun Yew, additional, Galli, Sofia, additional, Gallipoli, Paolo, additional, Hogan, Francesca, additional, Kalkur, Pallavi, additional, Khan, Anjum Bashir, additional, Krishnamurthy, Pramila, additional, Laurie, John, additional, Loo, Sun, additional, Marshall, Scott, additional, Mehta, Priyanka, additional, Murthy, Vidhya, additional, Nagumantry, Sateesh, additional, Pillai, Srinivas, additional, Potter, Nicola, additional, Sellar, Rob S., additional, Taylor, Tom, additional, Zhao, Rui, additional, Russell, Nigel H., additional, Wei, Andrew H., additional, and Dillon, Richard, additional

Published
2023
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14. Reducing the diversity of allogeneic transplant protocols in the UK through a BSBMT Anthony Nolan Protocol Harmonization Initiative

Author

Anthias, Chloe, Apperley, Jane, Bloor, Adrian, Byrne, Jennifer, Collin, Matthew, Crawley, Charles, Craddock, Charles, Finnegan, Damian, Gilleece, Maria, Gribben, John, Hunter, Ann, Hunter, Hannah, Koh, Mickey, Mackinnon, Stephen, Malladi, Ram, Marks, David, McQuaker, Grant, Nikolousis, Manos, Orchard, Kim, Pavlu, Jiri, Peniket, Andrew, Potter, Mike, Potter, Victoria, Robinson, Stephen, Russell, Nigel, Salim, Rahuman, Snowden, John, Thomson, Kirsty, Tholouli, Eleni, and Wilson, Keith

Published
2020
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15. Incidence, Risk Factors, and Long-term Outcome of Acute Leukemia Patients With Early Candidemia After Allogeneic Stem Cell Transplantation : A Study by the Acute Leukemia and Infectious Diseases Working Parties of European Society for Blood and Marrow Transplantation

Author

Cesaro, Simone, Tridello, Gloria, Blijlevens, Nicole, Ljungman, Per, Craddock, Charles, Michallet, Mauricette, Martin, Alexander, Snowden, John A., Mohty, Mohamad, Maertens, Johan, Passweg, Jacob, Petersen, Eefke, Nihtinen, Anne, Isaksson, Cecilia, Milpied, Noel, Rohlich, Pierre-Simon, Deconinck, Eric, Crawley, Charles, Ledoux, Marie-Pierre, Hoek, Jennifer, Nagler, Arnon, and Styczynski, Jan

Published
2018

16. Allogeneic haemopoietic transplantation for acute myeloid leukaemia in second complete remission: a registry report by the Acute Leukaemia Working Party of the EBMT

Author

Gilleece, Maria H., Labopin, Myriam, Savani, Bipin N., Yakoub-Agha, Ibrahim, Socié, Gerard, Gedde-Dahl, Tobias, Blaise, Didier, Byrne, Jennifer L., Craddock, Charles, Cornelissen, Jan J., Arcese, William, Forcade, Edouard, Crawley, Charles, Polge, Emmanuelle, Mohty, Mohamad, and Nagler, Arnon

Published
2020
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17. RNA-seq of newly diagnosed patients in the PADIMAC study leads to a bortezomib/lenalidomide decision signature

Author

Chapman, Michael A., Sive, Jonathan, Ambrose, John, Roddie, Claire, Counsell, Nicholas, Lach, Anna, Abbasian, Mahnaz, Popat, Rakesh, Cavenagh, Jamie D., Oakervee, Heather, Streetly, Matthew J., Schey, Stephen, Koh, Mickey, Willis, Fenella, Virchis, Andres E., Crowe, Josephine, Quinn, Michael F., Cook, Gordon, Crawley, Charles R., Pratt, Guy, Cook, Mark, Braganza, Nivette, Adedayo, Toyin, Smith, Paul, Clifton-Hadley, Laura, Owen, Roger G., Sonneveld, Pieter, Keats, Jonathan J., Herrero, Javier, and Yong, Kwee

Published
2018
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18. Adenovirus infections after allogeneic hematopoietic cell transplantation in children and adults: a study from the Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation

Author

Styczynski, Jan, Tridello, Gloria, Knelange, Nina, Wendel, Lotus, Ljungman, Per, Mikulska, Malgorzata, Gil, Lidia, Cesaro, Simone, Averbuch, Diana, von dem Borne, Peter, Xhaard, Aliénor, Mielke, Stephan, Neven, Benedicte, Snowden, John A., Dalle, Jean-Hugues, Rubio, Marie Thérèse, Crawley, Charles, Maertens, Johan, Kuball, Jurgen, Chevallier, Patrice, Michel, Gérard, Gabriel, Melissa, Burns, David, Wynn, Robert F., Renard, Cecile, Blijlevens, Nicole, Jubert, Charlotte, Gedde-Dahl, Tobias, Collin, Matthew, Labussiere-Wallet, Helene, Kalwak, Krzysztof, Broers, Annoek E. C., Yakoub-Agha, Ibrahim, Itäla-Remes, Maija, and de la Camara, Rafael

Abstract

The objective of the study was the analysis of clinical types, outcomes, and risk factors associated with the outcome of adenovirus (ADV) infection, in children and adults after allo-HCT. A total number of 2529 patients (43.9% children; 56.1% adults) transplanted between 2000 and 2022 reported to the EBMT database with diagnosis of ADV infection were analyzed. ADV infection manifested mainly as viremia (62.6%) or gastrointestinal infection (17.9%). The risk of 1-year mortality was higher in adults (p= 0.0001), and in patients with ADV infection developing before day +100 (p< 0.0001). The 100-day overall survival after diagnosis of ADV infections was 79.2% in children and 71.9% in adults (p< 0.0001). Factors contributing to increased risk of death by day +100 in multivariate analysis, in children: CMV seropositivity of donor and/or recipient (p= 0.02), and Lansky/Karnofsky score <90 (p< 0.0001), while in adults: type of ADV infection (viremia or pneumonia vs gastrointestinal infection) (p= 0.0004), second or higher HCT (p= 0.0003), and shorter time from allo-HCT to ADV infection (p= 0.003). In conclusion, we have shown that in patients infected with ADV, short-term survival is better in children than adults. Factors directly related to ADV infection (time, clinical type) contribute to mortality in adults, while pre-transplant factors (CMV serostatus, Lansky/Karnofsky score) contribute to mortality in children.

Published
2024
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19. Integrating biological HLA-DPB1 mismatch models to predict survival after unrelated hematopoietic cell transplantation

Author

Ruggeri, Annalisa, de Wreede, Liesbeth C., Muller, Carlheinz R., Crivello, Pietro, Bonneville, Edouard F., Petersdorf, Effie W., Socie, Gerard, Dubois, Valerie, Niittyvuopio, Riitta, Perasaari, Juha, Yakoub-Agha, Ibrahim, Cornelissen, Jan J., Wieten, Lotte, Gedde-Dahl, Tobias, Forcade, Edouard, Crawley, Charles R., Marsh, Steven G. E., Gandemer, Virginie, Tholouli, Eleni, Bulabois, Claude-Eric, Huynh, Anne, Choi, Goda, Deconinck, Eric, Itala-Remes, Maija, Lenhoff, Stig, Bengtsson, Mats, Johansson, Jan-Erik, van Gorkom, Gwendolyn, Hoogenboom, Jorinde D., Vago, Luca, Rocha, Vanderson, Bonini, Chiara, Chabannon, Christian, Fleischhauer, Katharina, HUS Comprehensive Cancer Center, Hematologian yksikkö, and Department of Oncology

Subjects
3122 Cancers, Hla-dp
Abstract

Non

Published
2023

20. Post‐transplant cyclophosphamide in acute leukemia patients receiving more than 5/10 HLA‐mismatched allogeneic hematopoietic cell transplantation from related donors: A study on behalf of the ALWP of the EBMT

Author

Wieczorek, Michele, primary, Labopin, Myriam, additional, Castagna, Luca, additional, Brissot, Eolia, additional, Socié, Gerard, additional, Raiola, Anna Maria, additional, Angelucci, Emanuele, additional, Rodríguez, Arancha Bermúdez, additional, Yakoub‐Agha, Ibrahim, additional, Aljurf, Mahmoud, additional, Crawley, Charles, additional, Mear, Jean Baptiste, additional, Musso, Maurizio, additional, Fanin, Renato, additional, Avenoso, Daniele, additional, Turlure, Pascal, additional, Tecchio, Cristina, additional, Sanz, Jaime, additional, Ciceri, Fabio, additional, Nagler, Arnon, additional, and Mohty, Mohamad, additional

Published
2022
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21. Comparison of Fludarabine/Melphalan (FluMel) with Fludarabine/Melphalan/BCNU or Thiotepa (FBM/FTM) in Patients with AML in First Complete Remission Undergoing Allogeneic Hematopoietic Stem Cell Transplantation - a Registry Study on Behalf of the EBMT Acute Leukemia Working Party

Author

Duque Afonso, Jesus, primary, Finke, Jürgen, additional, Ngoya, Maud, additional, Galimard, Jacques-Emmanuel, additional, Craddock, Charles, additional, Raj, Kavita, additional, Bloor, Adrian, additional, Nicholson, Emma, additional, Eder, Matthias, additional, Orchard, Kim H., additional, Valerius, Thomas, additional, Snowden, John A., additional, Tholouli, Eleni, additional, Crawley, Charles, additional, Collin, Matthew P., additional, Wilson, Keith, additional, Gadisseur, Alain, additional, Protheroe, Rachel Elizabeth, additional, Wagner, Eva Maria, additional, Savani, Bipin, additional, Spyridonidis, Alexandros, additional, Ciceri, Fabio, additional, Nagler, Arnon, additional, and Mohty, Mohamad, additional

Published
2022
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22. Autologous Peripheral Blood Stem Cell Mobilisation Techniques, Stem Cell Yields and Practice Variation-By-Country in Patients with Myeloma Undergoing First Autologous Stem Cell Transplants in EBMT Centres between 2012 and 2021

Author

Hayden, Patrick John, primary, Eikema, Dirk-Jan, additional, Koster, Linda, additional, Snowden, John A, additional, Caillot, Denis, additional, Van Gorkom, Gwendolyn, additional, Griskevicius, Laimonas, additional, Arcese, William, additional, Crawley, Charles, additional, Musso, Maurizio, additional, Bulabois, Claude-Eric, additional, Martin, Alexander M, additional, Netelenbos, Tanja, additional, McDonald, Andrew, additional, Maertens, Johan, additional, Parma, Matteo, additional, Illes, Arpad, additional, Isaksson, Cecilia, additional, Sossa, Claudia, additional, Drozd-Sokolowska, Joanna, additional, Raj, Kavita, additional, Beksac, Meral, additional, Schönland, Stefan, additional, McLornan, Donal P., additional, and Yakoub-Agha, Ibrahim, additional

Published
2022
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23. Molecular MRD Assessment Is Strongly Prognostic in Patients with NPM1 Mutated AML Receiving Venetoclax Based Non-Intensive Therapy

Author

Othman, Jad, primary, Tiong, Ing S, additional, Mokretar, Katya, additional, Ivey, Adam, additional, Austin, Michael James, additional, Latif, Anne-Louise, additional, Crawley, Charles, additional, Amer, Mariam, additional, Crolla, Francesca, additional, Cross, Joe W, additional, Dang, Raymond, additional, Fong, Chun Yew, additional, Galli, Sofia, additional, Gallipoli, Paolo, additional, Hogan, Francesca L, additional, Kalkur, Pallavi, additional, Khan, Anjum, additional, Krishnamurthy, Pramila, additional, Laurie, John, additional, Marshall, Scott R., additional, Murthy, Vidhya, additional, Nagumantry, Sateesh K., additional, Pillai, Srinivas, additional, Potter, Nicola, additional, Taylor, Tom, additional, Zhao, Rui, additional, Wei, Andrew H, additional, and Dillon, Richard, additional

Published
2022
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25. Comparison of fludarabine/melphalan (FluMel) with fludarabine/melphalan/BCNU or thiotepa (FBM/FTM) in patients with AML in first complete remission undergoing allogeneic hematopoietic stem cell transplantation – a registry study on behalf of the EBMT Acute Leukemia Working Party.

Author

Duque-Afonso, Jesus, primary, Finke, Jürgen, additional, Ngoya, Maud, additional, Galimard, Jacques-Emmanuel, additional, Craddock, Charles, additional, Raj, Kavita, additional, Bloor, Adrian, additional, Nicholson, Emma, additional, Eder, Matthias, additional, Kim, Orchard, additional, Valerius, Thomas, additional, Snowden, John, additional, Tholouli, Eleni, additional, Crawley, Charles, additional, Collin, Matthew, additional, Wilson, Keith, additional, Gadisseur, Alain, additional, Protheroe, Rachel, additional, Wagner-Drouet, Eva, additional, Savani, Bipin, additional, Spyridonidis, Alexandros, additional, Ciceri, Fabio, additional, Nagler, Arnon, additional, and Mohty, Mohamad, additional

Published
2022
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26. Molecular MRD is strongly prognostic in patients with NPM1-mutated AML receiving venetoclax-based nonintensive therapy

Author

Othman, Jad, Tiong, Ing S., O'Nions, Jenny, Dennis, Mike, Mokretar, Katya, Ivey, Adam, Austin, Michael, Latif, Anne-Louise, Amer, Mariam, Chan, Wei Yee, Crawley, Charles, Crolla, Francesca, Cross, Joe, Dang, Ray, Elliot, Johnathon, Fong, Chun Y., Galli, Sofia, Gallipoli, Paolo, Hogan, Francesca, Kalkur, Pallavi, Khan, Anjum, Krishnamurthy, Pramila, Laurie, John, Loo, Sun, Marshall, Scott, Mehta, Priyanka, Murthy, Vidhya, Nagumantry, Sateesh, Pillai, Srinivas, Potter, Nicola, Sellar, Rob, Taylor, Tom, Zhao, Rui, Russell, Nigel H., Wei, Andrew H., and Dillon, Richard

Published
2023
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27. Introducing biomarkers for invasive fungal disease in haemato-oncology patients: a single-centre experience

Author

Martinelli, Anthony W., primary, Wright, Callum B., additional, Lopes, Marta S., additional, Swayne, Rosemary L., additional, Krishnamurthy, Pramila, additional, Crawley, Charles, additional, Uttenthal, Ben, additional, Follows, George, additional, Babar, Judith, additional, Aliyu, Sani H., additional, Enoch, David A., additional, and Sander, Clare R., additional

Published
2022
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28. Impact of positron emission tomography - computed tomography status on progression-free survival for relapsed follicular lymphoma patients undergoing autologous stem cell transplantation

Author

Eyre, Toby A., primary, Barrington, Sally F., additional, Okosun, Jessica, additional, Abamba, Clementina, additional, Pearce, Rachel M., additional, Lee, Julia, additional, Carpenter, Ben, additional, Crawley, Charles R., additional, Bloor, Adrian J.C., additional, Gilleece, Maria, additional, Nicholson, Emma, additional, Shah, Nimish, additional, Orchard, Kim, additional, Malladi, Ram, additional, and Townsend, William M., additional

Published
2022
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29. Integrating biological HLA-DPB1 mismatch models to predict survival after unrelated hematopoietic cell transplantation

Author

Ruggeri, Annalisa, primary, De Wreede, Liesbeth C., additional, Müller, Carlheinz R., additional, Crivello, Pietro, additional, Bonneville, Edouard F., additional, Petersdorf, Effie W., additional, Socié, Gerard, additional, Dubois, Valérie, additional, Niittyvuopio, Riitta, additional, Peräsaari, Juha, additional, Yakoub-Agha, Ibrahim, additional, Cornelissen, Jan J., additional, Wieten, Lotte, additional, Gedde-Dahl, Tobias, additional, Forcade, Edouard, additional, Crawley, Charles R., additional, Marsh, Steven G.E., additional, Gandemer, Virginie, additional, Tholouli, Eleni, additional, Bulabois, Claude-Eric, additional, Huynh, Anne, additional, Choi, Goda, additional, Deconinck, Eric, additional, Itäla-Remes, Maija, additional, Lenhoff, Stig, additional, Bengtsson, Mats, additional, Johansson, Jan-Erik, additional, Van Gorkom, Gwendolyn, additional, Hoogenboom, Jorinde D., additional, Vago, Luca, additional, Rocha, Vanderson, additional, Bonini, Chiara, additional, Chabannon, Christian, additional, and Fleischhauer, Katharina, additional

Published
2022
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31. Post‐transplant cyclophosphamide in acute leukemia patients receiving more than 5/10 HLA‐mismatched allogeneic hematopoietic cell transplantation from related donors: A study on behalf of the ALWP of the EBMT.

Author

Wieczorek, Michele, Labopin, Myriam, Castagna, Luca, Brissot, Eolia, Socié, Gerard, Raiola, Anna Maria, Angelucci, Emanuele, Rodríguez, Arancha Bermúdez, Yakoub‐Agha, Ibrahim, Aljurf, Mahmoud, Crawley, Charles, Mear, Jean Baptiste, Musso, Maurizio, Fanin, Renato, Avenoso, Daniele, Turlure, Pascal, Tecchio, Cristina, Sanz, Jaime, Ciceri, Fabio, and Nagler, Arnon

Published
2023
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32. Post-Transplant MRD Status and T Cell Chimerism Predict Outcomes in Patients Allografted for AML/MDS-a Prospective Analysis from the UK NCRI Figaro Trial

Author

Ting Loke, Justin Ching, primary, McCarthy, Nicholas, additional, Jackson, Aimee, additional, Siddique, Shamyla, additional, Hodgkinson, Andrea, additional, Crawley, Charles, additional, Gilleece, Maria H., additional, Protheroe, Rachel, additional, Peniket, Andrew, additional, Salim, Rahuman, additional, Tholouli, Eleni, additional, Wilson, Keith M.O., additional, Andrew, Georgia, additional, Dillon, Richard, additional, Khan, Naeem, additional, Potter, Victoria, additional, Krishnamurthy, Pramila, additional, Craddock, Charles, additional, and Freeman, Sylvie, additional

Published
2022
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33. High-Dose Therapy and Autologous Stem Cell Transplantation in First Relapse for Diffuse Large B Cell Lymphoma in the Rituximab Era: An Analysis Based on Data from the European Blood and Marrow Transplantation Registry

Author

Mounier, Nicolas, Canals, Carmen, Gisselbrecht, Christian, Cornelissen, Jan, Foa, Roberto, Conde, Eulogio, Maertens, John, Attal, Michel, Rambaldi, Alessandro, Crawley, Charles, Luan, Jian-Jian, Brune, Mats, Wittnebel, Sebastian, Cook, Gordon, van Imhoff, G.W., Pfreundschuh, Michael, and Sureda, Anna

Published
2012
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34. Azacitidine augments expansion of regulatory T cells after allogeneic stem cell transplantation in patients with acute myeloid leukemia (AML)

Author

Goodyear, Oliver C., Dennis, Mike, Jilani, Nadira Y., Loke, Justin, Siddique, Shamyla, Ryan, Gordon, Nunnick, Jane, Khanum, Rahela, Raghavan, Manoj, Cook, Mark, Snowden, John A., Griffiths, Mike, Russell, Nigel, Yin, John, Crawley, Charles, Cook, Gordon, Vyas, Paresh, Moss, Paul, Malladi, Ram, and Craddock, Charles F.

Published
2012
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36. Post-Transplant MRD Status and T Cell Chimerism Predict Outcomes in Patients Allografted for AML/MDS-a Prospective Analysis from the UK NCRI Figaro Trial

Author

Loke, (Justin) Ching Ting, primary, McCarthy, Nicholas, additional, Jackson, Aimee E, additional, Siddique, Shamyla, additional, Hodgkinson, Andrea, additional, Mason, John, additional, Crawley, Charles, additional, Gilleece, Maria H, additional, Peniket, Andy, additional, Protheroe, Rachel Elizabeth, additional, Salim, Rahuman, additional, Tholouli, Eleni, additional, Wilson, Keith, additional, Andrew, Georgia M., additional, Dillon, Richard, additional, Khan, Naeem, additional, Potter, Victoria, additional, Krishnamurthy, Pramila, additional, Craddock, Charles, additional, and Freeman, Sylvie D, additional

Published
2021
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37. Post-Transplant Cyclophosphamide in Acute Leukemia Patients Receiving More Than 5/10 HLA-Mismatched Allogeneic Stem Cell Transplantation: A Study on Behalf of the ALWP of the EBMT

Author

Wieczorek, Michele, primary, Labopin, Myriam, additional, Castagna, Luca, additional, Brissot, Eolia, additional, Socié, Gerard, additional, Raiola, Anna Maria, additional, Angelucci, Emanuele, additional, Bermúdez, Arancha, additional, Yakoub-Agha, Ibrahim, additional, Aljurf, Mahmoud, additional, Crawley, Charles, additional, Mear, Jean-Baptiste, additional, Musso, Maurizio, additional, Fanin, Renato, additional, Avenoso, Daniele, additional, Turlure, Pascal, additional, Tecchio, Cristina, additional, Sanz, Jaime, additional, Ciceri, Fabio, additional, Nagler, Arnon, additional, and Mohty, Mohamad, additional

Published
2021
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39. Venetoclax with Azacitidine or Low Dose Cytarabine As an Alternative to Intensive Chemotherapy in Fit Adults during the COVID19 Pandemic: Real World Data from the UK National Health Service

Author

Othman, Jad, primary, Amer, Mariam, additional, Amofa, Ruebina, additional, Anderson, Laura, additional, Austin, Michael J, additional, Bashford, Alex, additional, Belsham, Edward, additional, Boot, Jesca, additional, Campbell, Victoria Louise, additional, Coats, Thomas, additional, Collins, Angela, additional, Crawley, Charles, additional, Crolla, Francesca, additional, Cross, Joe W, additional, Dalley, Chris, additional, Dang, Raymond, additional, Dennis, Mike, additional, Dhawan, Saniya, additional, Elliott, Johnathon, additional, Galli, Sofia, additional, Gallipoli, Paolo, additional, Hodgson, Katherine, additional, Jain, Manish, additional, Kalkur, Pallavi, additional, Katsomitrou, Vana, additional, Khan, Anjum, additional, Khwaja, Asim, additional, Krishnamurthy, Pramila, additional, Latif, Annie, additional, Laurie, John, additional, Lim, Michael, additional, Loizou, Eleana, additional, Loke, Justin, additional, Mannari, Deepak, additional, Manson, Cara, additional, Marshall, Scott R., additional, Mobashwera, Behnaz, additional, Murthy, Vidhya, additional, Ochaya, Odong, additional, Orthi, Shahzad, additional, Palanicawandar, Renuka, additional, Pillai, Srinivas, additional, Radzova, Dominika, additional, Rye, Adam, additional, Saunders, Jamie, additional, Smith, Matthew, additional, Taussig, David, additional, Taylor, Tom, additional, Whitmill, Richard, additional, Zhao, Rui, additional, Freeman, Sylvie D, additional, Craddock, Charles, additional, and Dillon, Richard, additional

Published
2021
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40. Defining nosocomial transmission of Escherichia coli and antimicrobial resistance genes: a genomic surveillance study

Author

Ludden, Catherine, primary, Coll, Francesc, additional, Gouliouris, Theodore, additional, Restif, Olivier, additional, Blane, Beth, additional, Blackwell, Grace A, additional, Kumar, Narender, additional, Naydenova, Plamena, additional, Crawley, Charles, additional, Brown, Nicholas M, additional, Parkhill, Julian, additional, and Peacock, Sharon J, additional

Published
2021
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41. HLA Class I Mismatches Reduce Survival after HCT in the Ptcy Era: A Study By the EBMT Cellular Therapy and Immunobiology Working Party

Author

Arrieta-Bolanos, Esteban, Bonneville, Edouard F., Robin, Marie, Gedde-Dahl, Tobias, Salmenniemi, Urpu, Kröger, Nicolaus, Yakoub-Agha, Ibrahim, Crawley, Charles, Choi, Goda, Broers, Annoek E. C., Forcade, Edouard, Carre, Martin, Poiré, Xavier, Huynh, Anne, Reményi, Péter, Lenhoff, Stig, Ciceri, Fabio, Tholouli, Eleni, Schröder, Thomas, Deconinck, Eric, Carlson, Kristina Elisabet, de Wreede, Liesbeth C., Hoogenboom, Jorinde D., Malard, Florent, Ruggeri, Annalisa, and Fleischhauer, Katharina

Published
2023
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42. Autologous Hematopoietic Cell Transplantation For Relapsed Multiple Myeloma Performed With Stem Cells Re-Mobilised Following A Prior AUTO-HCT - A Retrospective Study on Behalf of EBMT CMWP

Author

Byrne, Jennifer, Snowden, John A., Crawley, Charles, Colorado Araujo, Mercedes, de Wreede, Liesbeth, Passweg, Jakob, Van Gorkom, Gwendolyn, GÜRMAN, GÜNHAN, Zinger, Nienke, Gras, Luuk, Yakoub-Agha, Ibrahim, Schoenland, Stefan, Tilly, Herve, BEKSAÇ, MERAL, Hayden, Patrick, Bulabois, Claude Eric, Arat, Mutlu, Basak, Grzegorz, Pouli, Anastasia, Poire, Xavier, Wilson, Keith M. O., Lioure, Bruno, Schroyens, Wilfried, ÖZKURT, ZÜBEYDE NUR, and Drozd-Sokolowska, Joanna

Published
2021

43. Recommendations for a standard UK approach to incorporating umbilical cord blood into clinical transplantation practice: an update on cord blood unit selection, donor selection algorithms and conditioning protocols

Author

Hough, Rachael, Danby, Robert, Russell, Nigel, Marks, David, Veys, Paul, Shaw, Bronwen, Wynn, Rob, Vora, Ajay, Mackinnon, Stephen, Peggs, Karl S., Crawley, Charles, Craddock, Charlie, Pagliuca, Antonio, Cook, Gordon, Snowden, John A., Clark, Andrew, Marsh, Judith, Querol, Sergio, Parkes, Guy, Braund, Henny, and Rocha, Vanderson

Published
2016
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44. Impact of in vivo alemtuzumab dose before reduced intensity conditioning and HLA-identical sibling stem cell transplantation: pharmacokinetics, GVHD, and immune reconstitution

Author

Chakraverty, Ronjon, Orti, Guillermo, Roughton, Michael, Shen, Jun, Fielding, Adele, Kottaridis, Panagiotis, Milligan, Donald, Collin, Matthew, Crawley, Charles, Johnson, Peter, Clark, Andrew, Parker, Anne, Bloor, Adrian, Pettengell, Ruth, Snowden, John, Pettitt, Andrew, Clark, Richard, Hale, Geoff, Peggs, Karl, Thomson, Kirsty, Morris, Emma, and Mackinnon, Stephen

Published
2010
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45. From Charts to Glyphs: Rudolf Modley's Contribution to Visual Communication.

Author

Crawley, Charles R.

Abstract

Suggests that visual communicators have much to learn from Rudolf Modley, who designed many pictorial symbols in the 1930s and 1940s worthy of study. Argues that his call for an international system of symbols is as pressing and pertinent today as it was when he made it over 20 years ago. (SR)

Published
1994

46. Donor-Recipient HLA Matching for Unrelated Donor Hematopoietic Stem Cell Transplantation Outcomes: A Study from the Cellular Therapy and Immunobiology Working Party (CTIWP) of the EBMT A Study from the Cellular Therapy and Immunobiology Working Party (CTIWP) of the EBMT

Author

Ruggeri, Annalisa, Mueller, Carlheninz, Mauff, Katya, de Wreede, Lisbeth, Wieten, Lotte, Vago, Luca, Hoogenboom, Jorinde, Socie, Gerard, Niittyvuopio, Riitta, Yakoubagha, Ibrahim, Crawley, Charles, Tholouli, Eleni, Bulabois, Claude Eric, Choi, Goda, Forcade, Edouard, Huynh, Anne, Lenhoff, Stig, Gandemer, Virginie, Ciceri, Fabio, Kroeger, Nicolaus, Maillard, Natacha, Itala-Remes, Maija, Rocha, Vanderson, Bonini, Chiara, Chabannon, Christian, and Fleischhauer, Katharina

Published
2020

47. Augmented Reduced-Intensity Regimen Does Not Improve Postallogeneic Transplant Outcomes in Acute Myeloid Leukemia

Author

Craddock, Charles, primary, Jackson, Aimee, additional, Loke, Justin, additional, Siddique, Shamyla, additional, Hodgkinson, Andrea, additional, Mason, John, additional, Andrew, Georgia, additional, Nagra, Sandeep, additional, Malladi, Ram, additional, Peniket, Andrew, additional, Gilleece, Maria, additional, Salim, Rahuman, additional, Tholouli, Eleni, additional, Potter, Victoria, additional, Crawley, Charles, additional, Wheatley, Keith, additional, Protheroe, Rachel, additional, Vyas, Paresh, additional, Hunter, Ann, additional, Parker, Anne, additional, Wilson, Keith, additional, Pavlu, Jiri, additional, Byrne, Jenny, additional, Dillon, Richard, additional, Khan, Naeem, additional, McCarthy, Nicholas, additional, and Freeman, Sylvie D., additional

Published
2021
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48. A One Health Study of the Genetic Relatedness of Klebsiella pneumoniae and Their Mobile Elements in the East of England

Author

Ludden, Catherine, Moradigaravand, Danesh, Jamrozy, Dorota, Gouliouris, Theodore, Blane, Beth, Naydenova, Plamena, Hernandez-Garcia, Juan, Wood, Paul, Hadjirin, Nazreen, Radakovic, Milorad, Crawley, Charles, Brown, Nicholas M, Holmes, Mark, Parkhill, Julian, Peacock, Sharon J, Ludden, Catherine [0000-0001-9503-0744], Hernandez-Garcia, Juan [0000-0001-5932-9327], Holmes, Mark [0000-0002-5454-1625], Parkhill, Julian [0000-0002-7069-5958], Peacock, Sharon [0000-0002-1718-2782], and Apollo - University of Cambridge Repository

Subjects
Cross Infection, Microbial Sensitivity Tests, United Kingdom, beta-Lactamases, Anti-Bacterial Agents, Klebsiella Infections, Klebsiella pneumoniae, Cross-Sectional Studies, England, genomics, surveillance, Animals, Humans, Cattle, One Health, antimicrobial resistance, Articles and Commentaries, Klebsiella pneumonia
Abstract

Background Klebsiella pneumoniae is a human, animal, and environmental commensal and a leading cause of nosocomial infections, which are often caused by multiresistant strains. We evaluate putative sources of K. pneumoniae that are carried by and infect hospital patients. Methods We conducted a 6-month survey on 2 hematology wards at Addenbrooke’s Hospital, Cambridge, United Kingdom, in 2015 to isolate K. pneumoniae from stool, blood, and the environment. We conducted cross-sectional surveys of K. pneumoniae from 29 livestock farms, 97 meat products, the hospital sewer, and 20 municipal wastewater treatment plants in the East of England between 2014 and 2015. Isolates were sequenced and their genomes compared. Results Klebsiella pneumoniae was isolated from stool of 17/149 (11%) patients and 18/922 swabs of their environment, together with 1 bloodstream infection during the study and 4 others over a 24-month period. Each patient carried 1 or more lineages that was unique to them, but 2 broad environmental contamination events and patient–environment transmission were identified. Klebsiella pneumoniae was isolated from cattle, poultry, hospital sewage, and 12/20 wastewater treatment plants. There was low genetic relatedness between isolates from patients/their hospital environment vs isolates from elsewhere. Identical genes encoding cephalosporin resistance were carried by isolates from humans/environment and elsewhere but were carried on different plasmids. Conclusion We identified no patient-to-patient transmission and no evidence for livestock as a source of K. pneumoniae infecting humans. However, our findings reaffirm the importance of the hospital environment as a source of K. pneumoniae associated with serious human infection., A One Health genomic survey of Klebsiella pneumoniae demonstrated transmission between patients and their ward environment but no evidence to implicate livestock as a source of K. pneumoniae or their mobile genetic elements encoding antibiotic resistance.

Published
2020

49. Quantifying acquisition and transmission of Enterococcus faecium using genomic surveillance

Author

Gouliouris, Theodore, primary, Coll, Francesc, additional, Ludden, Catherine, additional, Blane, Beth, additional, Raven, Kathy E., additional, Naydenova, Plamena, additional, Crawley, Charles, additional, Török, Mili Estée, additional, Enoch, David A., additional, Brown, Nicholas M., additional, Harrison, Ewan M., additional, Parkhill, Julian, additional, and Peacock, Sharon J., additional

Published
2020
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