1. The 2019–2020 Dengue Fever Epidemic: Genomic Markers Indicating Severity in Dominican Republic Children.
- Author
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Simpson, Brittany N, Sang, Miguel E Mejía, Puello, Yonairy Collado, Brockmans, Elvira J Diaz, Soto, María F Díaz, Defilló, Stephanie M Rivera, Cruz, Karla M Taveras, Pérez, Javier O Santiago, Husami, Ammar, Day, Melissa E, Pilipenko, Valentina, Mena, Rafael, Mota, Cesár, Hostetter, Margaret K, Muglia, Louis J, Schlaudecker, Elizabeth, Rey, Javier Gonzalez del, Martin, Lisa J, and Prada, Carlos E
- Subjects
DENGUE ,SCIENTIFIC observation ,SEVERITY of illness index ,RISK assessment ,GENOMICS ,GENETIC markers ,DESCRIPTIVE statistics ,RESEARCH funding ,LONGITUDINAL method - Abstract
We performed an observational cohort study to assess associations between genetic factors of dengue fever (DF) severity in children in the Dominican Republic. A total of 488 participants had serologically confirmed DF. We replicated the association between the IFIH1 gene (rs1990760) and severe DF (n = 80/488, p = 0.006) and identified novel associations needing further investigation. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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