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4 results on '"Cyrille Orizet"'

1. Occurrence and severity of cocaine-induced hallucinations: Two distinct phenotypes with shared clinical factors but specific genetic risk factors

Author

El-Hadi Zerdazi, Emmanuel Curis, Emily Karsinti, Romain Icick, Maeva Fortias, Philippe Batel, Olivier Cottencin, Cyrille Orizet, Aurélia Gay, Philippe Coeuru, Alice Deschenau, Philippe Lack, Delphine Moisan, Anne-Laure Pelissier-Alicot, Arnaud Plat, Jean-Baptiste Trabut, Isabelle Kousignian, Luana Boumendil, Eric Vicaut, Nathalie Prince, Jean-Louis Laplanche, Frank Bellivier, Jean-Pierre Lépine, Cynthia Marie-Claire, Georges Brousse, Florence Vorspan, and Vanessa Bloch

Subjects
Pharmacology, Psychiatry and Mental health, Cocaine-Related Disorders, Phenotype, Cocaine, Hallucinations, Risk Factors, Humans, Pharmacology (medical), Toxicology
Abstract

Cocaine-induced transient hallucinations (CIH) are a frequent complication following cocaine intake that is associated with addiction severity.Two hundred and forty-two non-psychotic and Caucasian lifetime cocaine users were included in a French multicentric study. Clinical variables and dopamine pathway genotype data were extracted and tested with CIH scores using a zero-inflated binomial model, which allows for the exploration of factors associated with occurrence and severity separately.Cocaine dependence (pOur study shows that CIH occurrence and severity are two distinct phenotypes, with shared clinical risk factors; however, they likely do not share the same genetic background.

Published
2021

2. Anxiety disorders are associated with early onset of heroin use and rapid transition to dependence in methadone maintained patients

Author

M. Jarroir, Anne-Marie Simonpoli, Philippe Coeuru, Frank Bellivier, Florence Vorspan, Vanessa Bloch, Romain Icick, Emily Karsinti, Pierre Polomeni, Beatriz Belforte, Jan Scott, Didier Touzeau, Elisabeth Avril, Gaël Dupuy, Maeva Fortias, Cyrille Orizet, Xavier Laqueille, Jean-Pierre Lépine, and Kamilia Ksouda

Subjects
Adult, Male, medicine.medical_specialty, Methadone maintenance, Time Factors, Heroin, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Heroin dependence, mental disorders, medicine, Opiate Substitution Treatment, Humans, Age of Onset, Psychiatry, Biological Psychiatry, Early onset, Retrospective Studies, biology, Heroin Dependence, Cannabis use, Middle Aged, biology.organism_classification, Anxiety Disorders, 030227 psychiatry, Analgesics, Opioid, Psychiatry and Mental health, Anxiety, Female, Cannabis, medicine.symptom, Psychology, 030217 neurology & neurosurgery, Methadone, medicine.drug, Clinical psychology
Abstract

Early onset of heroin use is a severity marker of heroin use disorder. We studied the interaction between early onset and rapid transition to heroin dependence recorded with retrospective interviews in 213 patients with severe heroin dependence and history of methadone maintenance treatment. General linear models were used to identify independent factors associated with early onset, factors associated with rapid transition to dependence, and a multivariate model was used to study the interaction of those two dimensions. Lifetime history of anxiety disorders and age at onset of cannabis use are shared common risk factors and are associated with the interaction.

Published
2015

3. Transient cocaine-induced chest pain: a case series

Author

Florence Vorspan, Cyrille Orizet, Vanessa Bloch, Maeva Fortias, Jean-Pierre Lépine, Etienne Puymirat, Gaël Dupuy, Yavor Delchev, and Frank Bellivier

Subjects
Adult, Male, medicine.medical_specialty, Chest Pain, Paris, Time Factors, media_common.quotation_subject, Psychological intervention, Comorbidity, Chest pain, Logistic regression, Cocaine-Related Disorders, Electrocardiography, Young Adult, Recurrence, Risk Factors, medicine, Prevalence, Humans, Pharmacology (medical), Myocardial infarction, media_common, Retrospective Studies, business.industry, Addiction, Cocaine induced chest pain, Emergency department, Middle Aged, medicine.disease, Causality, Psychiatry and Mental health, Cross-Sectional Studies, Emergency medicine, Female, medicine.symptom, Age of onset, business, Emergency Service, Hospital
Abstract

OBJECTIVES Acute chest pain and myocardial infarction are frequent complications of cocaine use. Indeed, these represent 40% of emergency department visits associated with cocaine use and 2% to 7% of all patients attending the emergency department for chest pain. Nevertheless, the prevalence of past cocaine-associated chest pain has never been evaluated in an outpatient facility for addiction. Our objective was to assess lifetime episodes of cocaine-associated chest pain in current cocaine users in an outpatient facility. METHODS Fifty consecutive, nonselected current cocaine users were retrospectively evaluated with a standardized interview and a medical assessment. The patients and the pain characteristics are described, and clinical and biological factors associated with experiencing cocaine-associated chest pain are studied with univariate and logistic regressions analyses. RESULTS Twenty-six subjects (52%) reported a history of chest pain associated with cocaine use. This pain was frequently described as oppressive (28%) and located in the retrosternal area (61.5%). The mean (±SD) time between cocaine use and the occurrence of the pain was 8 (±8) minutes and the mean duration was 22 (±236) minutes. Subjects who reported cocaine-associated chest pain reported an average of 12 (±7) distinct episodes. Patients describing chest pain could be predicted with one independent factor in our sample: age of onset of cocaine use (P = 0.042). CONCLUSIONS Transient cocaine-associated chest pains are frequent in current cocaine users attending specialized addiction facilities. Cardiological explorations and monitoring and risk-reduction interventions need to be provided to this specific population.

Published
2014

4. Alterations in nicotinic receptor alpha5 subunit gene differentially impact early and later stages of cocaine addiction: a translational study in transgenic rats and patients

Author

Morgane Besson, Benoit Forget, Marc Gielen, Marie S. Prevost, Jonathan Robert, Uwe Maskos, Florence Vorspan, Pierre-Jean Corringer, Frank Bellivier, Romain Icick, Caroline Correia, Neurobiologie intégrative des Systèmes cholinergiques / Integrative Neurobiology of Cholinergic Systems (NISC), Institut Pasteur [Paris]-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Département de Psychiatrie et de Médecine Addictologique, Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S_1144 / U1144)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Sorbonne Université (SU), Récepteurs Canaux - Channel Receptors, Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], This work was supported by the Institut Pasteur, Centre National de la Recherche Scientifique UMR 3571, Fondation pour la Recherche Médicale (SPF20140129365, DPA20140629803 and EQU201903007822), Agence Nationale de la Recherche (ANR), Neuroscience 'SNP-NIC' and BLANC, LABEX BIO-PSY, FP7 ERANET program NICO-GENE grant agreement convention ANR n° 2010-NEUR-004-01, European Commission FP7 RTD Project HEALTH-2009-Neurocyp.08-202088 grant 242167, French National Cancer Institute grant CANCEROPOLE IDF 2016-1-TABAC-01-IP-1 MASKOS, European ERANET programme iPS&BRAIN (all to U.M.). The laboratory of U.M. is part of the Ecole des Neurosciences de Paris Ile-de-France RTRA network. R.I., U.M., P-J.C, F.V. and F.B. are members of the LABEX BIO-PSY. This work was supported by French state funds managed by the ANR within the Investissements d’Avenir programme under reference ANR-11-IDEX-0004-02, and by the Programme Hospitalier de Recherche Clinique (PHRC) from the French Ministry of Health (AOM10165)., The authors are thankful to the Direction de le Recherche Clinique et de l'Innovation from the Assistance Publique - Hôpitaux de Paris that acted as the study promotor, and to Pr Georges Brousse (Clermont-Ferrand), Dr Maeva Fortias, Ms Emily Karsinti, Dr Vanessa Bloch (CSAPA Murger Paris), Dr Cyrille Orizet (CSAPA Monte Christo, Paris), Dr Philippe Coeuru (CSAPA Aurore-EGO, Paris), Pr Olivier Cottencin (Lille), Dr Philippe Batel (Clichy), Dr Alice Deschesneau (CSAPA Liberté, Ivry), Dr Philipppe Lack (Lyon), Dr Aurélia Gay (St Etienne) and Dr Trabut (Limeil-Brevannes) who helped collecting the data, and to the patients who participated. The genetic study in humans was designed and conducted during a ‘Poste d’accueil’ research fellowship from Assistance Publique – Hôpitaux de Paris and LABEX BIO-PSY obtained by R.I., ANR-10-NEUR-0004,NICO-GENE(2010), ANR-17-CE16-0016,SNP-NIC,Les polymorphismes humains du récepteur nicotinique---Modélisation de leur rôle dans des rats et souris transgénique(2017), ANR-11-IDEX-0004,SUPER,Sorbonne Universités à Paris pour l'Enseignement et la Recherche(2011), European Project: 242167,EC:FP7:HEALTH,FP7-HEALTH-2009-two-stage,SYNSYS(2010), Laatabi, Rhizlane, Appel à projets transnational sur les maladies neurodégénératives, dans le cadre de l'ERAnet NEURON - - NICO-GENE2010 - ANR-10-NEUR-0004 - ERAnet NEURON - VALID, Les polymorphismes humains du récepteur nicotinique---Modélisation de leur rôle dans des rats et souris transgénique - - SNP-NIC2017 - ANR-17-CE16-0016 - AAPG2017 - VALID, Sorbonne Universités à Paris pour l'Enseignement et la Recherche - - SUPER2011 - ANR-11-IDEX-0004 - IDEX - VALID, Synaptic Systems: dissecting brain function in health and disease - SYNSYS - - EC:FP7:HEALTH2010-07-01 - 2014-12-31 - 242167 - VALID, Institut Pasteur [Paris] (IP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), and Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)

Subjects
0301 basic medicine, medicine.medical_specialty, Candidate gene, nicotinic receptors, nucleus accumbens, media_common.quotation_subject, Protein subunit, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.NEU.PC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, Single-nucleotide polymorphism, Biology, Nucleus accumbens, Receptors, Nicotinic, human polymorphisms, 03 medical and health sciences, Cocaine-Related Disorders, 0302 clinical medicine, Cocaine, Recurrence, Internal medicine, medicine, Animals, Humans, transgenic rats, Receptor, media_common, relapse, [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, General Neuroscience, Addiction, CHRNA5, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Rats, cocaine use disorder, 030104 developmental biology, Nicotinic agonist, Endocrinology, biology.protein, Rats, Transgenic, Neuroscience, 030217 neurology & neurosurgery
Abstract

International audience; Cocaine addiction is a chronic and relapsing disorder with an important genetic component. Human candidate gene association studies showed that the single nucleotide polymorphism (SNP) rs16969968 in the α5 subunit (α5SNP) of nicotinic acetylcholine receptors (nAChRs), previously associated with increased tobacco dependence, was linked to a lower prevalence of cocaine use disorder (CUD). Three additional SNPs in the α5 subunit, previously shown to modify α5 mRNA levels, were also associated with CUD, suggesting an important role of the subunit in this pathology. To investigate the link between this subunit and CUD, we submitted rats knockout for the α5 subunit gene (α5KO), or carrying the α5SNP, to cocaine self-administration (SA) and showed that the acquisition of cocaine-SA was impaired in α5SNP rats while α5KO rats exhibited enhanced cocaine-induced relapse associated with altered neuronal activity in the nucleus accumbens. In addition, we observed in a human cohort of patients with CUD that the α5SNP was associated with a slower transition from first cocaine use to CUD. We also identified a novel SNP in the β4 nAChR subunit, part of the same gene cluster in the human genome and potentially altering CHRNA5 expression, associated with shorter time to relapse to cocaine use in patients. In conclusion, the α5SNP is protective against CUD by influencing early stages of cocaine exposure while CHRNA5 expression levels may represent a biomarker for the risk to relapse to cocaine use. Drugs modulating α5 containing nAChR activity may thus represent a novel therapeutic strategy against CUD.

Published
2020
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