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2. Case report: Cerebrotendinous xanthomatosis treatment follow-up.

Author

Ejsmont-Sowała, Karolina, Książek, Tomasz, Maciorowska-Rosłan, Katarzyna, Rosłan, Joanna, Czarnowska, Agata, Jakubiuk-Tomaszuk, Anna, Tarasiuk, Joanna, Kapica-Topczewska, Katarzyna, and Kułakowska, Alina

Subjects
GENETIC profile, CHENODEOXYCHOLIC acid, CEREBELLAR ataxia, CLINICAL deterioration, GENETIC disorders
Abstract

Xanthomatosis is a genetic disease inherited in an autosomal recessive manner. The specific phenotypic features are associated with patient's genetic profile. The result of the mutation is disorder of cholesterol synthesis and the accumulation of its precursors in tissues. The characteristic symptoms are progressive cerebellar ataxia, cataract, diarrhea, and the deposition of cholesterol in the tendons. Our objective is to follow-up information to treatment efficacy of 22-yearold patient diagnosed with cerebrotendinous xanthomatosis through 1.5 year observation. In 2012, an 11-year-old patient with a long history of deformed feet and frequent yellowing of the skin, was admitted to the Department of Neurology due to seizures. In 2013, the patient began to suffer from diarrhea, and its frequency was correlated with the concentration of bilirubin in the blood. In the same year cataract was diagnosed. Gradually, the patient starts to complain about progressive difficulties in moving. In 2019, genetic tests confirmed the diagnosis of cerebrotendinous xanthomatosis. Since July 2021, the patient has been treated with chenodeoxycholic acid. The deterioration of patient's mobility has been significantly inhibited, consequently his quality of life has improved. The presented case report underscores the efficacy of CDCA supplementation in halting the progression of CTX, resulting in marked improvements in the patient's quality of life. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Analysis of the Presence and Levels of IgG Antibodies Directed against the S1 Protein Receptor Binding Domain and the N Protein of SARS-CoV-2 in Patients with Multiple Sclerosis Treated with Immunomodulatory Therapies

Author

Kulikowska, Joanna, primary, Kapica-Topczewska, Katarzyna, additional, Gudowska-Sawczuk, Monika, additional, Kulczyńska-Przybik, Agnieszka, additional, Bazylewicz, Marcin, additional, Mirończuk, Anna, additional, Czarnowska, Agata, additional, Brola, Waldemar, additional, Mroczko, Barbara, additional, Kochanowicz, Jan, additional, and Kułakowska, Alina, additional

Published
2024
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4. Analysis of seroconversion following COVID-19 vaccination among multiple sclerosis patients treated with disease-modifying therapies in Poland

Author

Podlecka-Piętowska, Aleksandra, primary, Sierdziński, Janusz, additional, Nojszewska, Monika, additional, Stawicki, Jakub, additional, Bartosik-Psujek, Halina, additional, Lech, Beata, additional, Popiel, Małgorzata, additional, Perenc, Adam, additional, Kułakowska, Alina, additional, Czarnowska, Agata, additional, Kulikowska, Joanna, additional, Kapica-Topczewska, Katarzyna, additional, Jamróz-Wiśniewska, Anna, additional, Rejdak, Konrad, additional, Zaborski, Jacek, additional, Kubicka-Bączyk, Katarzyna, additional, Niedziela, Natalia, additional, Wierzbicki, Krzysztof, additional, Adamczyk-Sowa, Monika, additional, Zwiernik, Jacek, additional, Zwiernik, Beata, additional, Milewska-Jędrzejczak, Marta, additional, Głąbiński, Andrzej, additional, Jasińska, Elżbieta, additional, Puz, Przemysław, additional, Krzystanek, Ewa, additional, Stęposz, Arkadiusz, additional, Karuga, Aleksandra, additional, Lasek-Bal, Anetta, additional, Siuda, Joanna, additional, Kściuk, Barbara, additional, Walawska-Hrycek, Anna, additional, Patalong-Ogiewa, Maja, additional, Kaczmarczyk, Aleksandra, additional, Siutka, Katarzyna, additional, Brola, Waldemar, additional, and Zakrzewska-Pniewska, Beata, additional

Published
2024
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5. Sense of happiness in Polish patients with multiple sclerosis

Author

Brola, Waldemar, primary, Szcześniak, Małgorzata, additional, Wilski, Maciej, additional, Żak, Marek, additional, Sobolewski, Piotr, additional, Wnuk, Marcin, additional, Szałachowski, Roman Ryszard, additional, Kapica-Topczewska, Katarzyna, additional, Czarnowska, Agata, additional, Tarasiuk, Joanna, additional, Kułakowska, Alina, additional, Zakrzewska-Pniewska, Beata, additional, Kubicka-Bączyk, Katarzyna, additional, Morawiec, Natalia, additional, Adamczyk-Sowa, Monika, additional, Stępień, Adam, additional, Zaborski, Jacek, additional, Bartosik-Psujek, Halina, additional, Lech, Beata, additional, Perenc, Adam, additional, Popiel, Małgorzata, additional, Ratajczak, Anna, additional, Ratajczak, Marcin, additional, Kroplewski, Zdzisław, additional, and Potemkowski, Andrzej, additional

Published
2023
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6. Religious meaning system and life satisfaction: the mediating role of meaning in life among Polish people with multiple sclerosis.

Author

Wilski, Maciej, Wnuk, Marcin, Brola, Waldemar, Szcześniak, Małgorzata, Żak, Marek, Sobolewski, Piotr, Kapica-Topczewska, Katarzyna, Tarasiuk, Joanna, Czarnowska, Agata, Kułakowska, Alina, Zakrzewska-Pniewska, Beata, Bartosik-Psujek, Halina, Kubicka-Bączyk, Katarzyna, Morawiec, Natalia, Adamczyk-Sowa, Monika, Stepien, Adam, Jacek, Zaborski, Ratajczak, Anna, Ratajczak, Marcin, and Szałachowski, Roman

Subjects
LIFE satisfaction, MENTAL health services, POLISH people, MULTIPLE sclerosis, SUBJECTIVE well-being (Psychology)
Abstract

Introduction: The complexity of the associations between religiosity and indicators of well-being suggests the presence of a mediating mechanism. Previous studies indicate that religion may influence subjective well-being because it helps to find meaning and purpose. Therefore, the aim of our study was to examine the mediating role of the presence and search dimensions of meaning in life in the relationship between religious meaning system and life satisfaction in patients with multiple sclerosis (MS). Methods: This cross-sectional study included 600 MS patients recruited from Poland who completed the Satisfaction with Life Scale (SWLS), the Religious Meaning System Questionnaire (RMS) and the Meaning in Life Questionnaire (MLQ). Model 6 of Hayes PROCESS was used to test the hypotheses. Results: The results of our research indicate that there was a significant indirect effect of religious meaning system on life satisfaction through the presence of meaning in life. The specific indirect effect of religious meaning system on life satisfaction through searching for meaning in life was not significant. Discussion: The results of our study are relevant because they show that religion as a meaning system is positively related to the presence of meaning in life, which in turn positively predicts life satisfaction. This is particularly important in the case of incurable illness, where finding meaning in life is one of the natural stages of adaptation. By incorporating these findings into mental health practice, professionals can enhance the holistic well-being of people coping with MS and contribute to a more comprehensive and effective approach to mental health care. [ABSTRACT FROM AUTHOR]

Published
2024
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13. The Clinical and Epidemiological Profile of Paediatric-Onset Multiple Sclerosis in Poland

Author

Brola, Waldemar, primary, Steinborn, Barbara, additional, Żak, Marek, additional, Mazurkiewicz-Bełdzińska, Maria, additional, Jóźwiak, Sergiusz, additional, Sobolewski, Piotr, additional, Wilski, Maciej, additional, Bilska, Małgorzata, additional, Siedlarska, Magdalena, additional, Puzio-Bochen, Iwona, additional, Wencel-Warot, Agnieszka, additional, Lemka, Małgorzata, additional, Kroczka, Sławomir, additional, Czyżyk, Elżbieta, additional, Bocheńska, Małgorzata, additional, Emich-Widera, Ewa, additional, Pietruszewski, Jerzy, additional, Boćkowski, Leszek, additional, Kapica-Topczewska, Katarzyna, additional, Czarnowska, Agata, additional, Kułakowska, Alina, additional, Ujma-Czapska, Barbara, additional, Gruna-Ożarowska, Agata, additional, Przysło, Łukasz, additional, Połatyńska, Katarzyna, additional, Dudzińska, Magdalena, additional, Mitosek-Szewczyk, Krystyna, additional, Melnyk, Aleksandra, additional, Adamczyk-Sowa, Monika, additional, and Kotulska, Katarzyna, additional

Published
2022
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14. Antibodies against SARS-CoV-2 S and N proteins in relapsing-remitting multiple sclerosis patients treated with disease-modifying therapies

Author

Kulikowska, Joanna, primary, Czarnowska, Agata, additional, Gudowska-Sawczuk, Monika, additional, Kulczyńska-Przybik, Agnieszka, additional, Bazylewicz, Marcin, additional, Collins, Francois, additional, Chorąży, Monika, additional, Mroczko, Barbara, additional, Kochanowicz, Jan, additional, Kapica-Topczewska, Katarzyna, additional, and Kułakowska, Alina, additional

Published
2022
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15. Model of the Relationship of Religiosity and Happiness of Multiple Sclerosis Patients from Poland: The Role of Mediating and Moderating Variables

Author

Wnuk, Marcin, primary, Wilski, Maciej, additional, Szcześniak, Małgorzata, additional, Bartosik-Psujek, Halina, additional, Kapica-Topczewska, Katarzyna, additional, Tarasiuk, Joanna, additional, Czarnowska, Agata, additional, Kułakowska, Alina, additional, Zakrzewska-Pniewska, Beata, additional, Brola, Waldemar, additional, Żak, Marek, additional, Sobolewski, Piotr, additional, Morawiec, Natalia, additional, Adamczyk-Sowa, Monika, additional, Stępień, Adam, additional, Ratajczak, Marcin, additional, Ratajczak, Anna, additional, Zaborski, Jacek, additional, Kubicka-Bączyk, Katarzyna, additional, Szałachowski, Roman Ryszard, additional, Kroplewski, Zdzisław, additional, Lech, Beata, additional, Perenc, Adam, additional, Popiel, Małgorzata, additional, and Potemkowski, Andrzej, additional

Published
2022
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16. Model of the relationship of religiosity and happiness of Multiple Sclerosis patients from Poland. Role of mediating and moderating variables

Author

Wnuk, Marcin, primary, Wilski, Maciej, additional, Brola, Waldemar, additional, Żak, Marek, additional, Sobolewski, Piotr, additional, Kapica-Topczewska, Katarzyna, additional, Tarasiuk, Joanna, additional, Czarnowska, Agata, additional, Kułakowska, Alina, additional, Zakrzewska-Pniewska, Beata, additional, Kubicka-Bączyk, Katarzyna, additional, Morawiec, Natalia, additional, Adamczyk-Sowa, Monika, additional, Stępień, Adam, additional, Zaborski, Jacek, additional, Ratajczak, Anna, additional, Ratajczak, Marcin, additional, Szałachowski, Roman, additional, Szcześniak, Małgorzata, additional, Kroplewski, Zdzisław, additional, Bartosik-Psujek, Halina, additional, Lech, Beata, additional, Perenc, Adam, additional, Popiel, Małgorzata, additional, and Potemkowski, Andrzej, additional

Published
2022
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17. Analysis of Side Effects Following Vaccination Against COVID-19 Among Individuals With Multiple Sclerosis Treated With DMTs in Poland

Author

Czarnowska, Agata, primary, Tarasiuk, Joanna, additional, Zajkowska, Olga, additional, Wnuk, Marcin, additional, Marona, Monika, additional, Nowak, Klaudia, additional, Słowik, Agnieszka, additional, Jamroz-Wiśniewska, Anna, additional, Rejdak, Konrad, additional, Lech, Beata, additional, Popiel, Małgorzata, additional, Rościszewska-Żukowska, Iwona, additional, Perenc, Adam, additional, Bartosik-Psujek, Halina, additional, Świderek-Matysiak, Mariola, additional, Siger, Małgorzata, additional, Ciach, Agnieszka, additional, Walczak, Agata, additional, Jurewicz, Anna, additional, Stasiołek, Mariusz, additional, Kania, Karolina, additional, Dyczkowska, Klara, additional, Kalinowska-Łyszczarz, Alicja, additional, Galus, Weronika, additional, Walawska-Hrycek, Anna, additional, Krzystanek, Ewa, additional, Chojdak-Łukasiewicz, Justyna, additional, Ubysz, Jakub, additional, Pokryszko-Dragan, Anna, additional, Kapica-Topczewska, Katarzyna, additional, Chorąży, Monika, additional, Bazylewicz, Marcin, additional, Mirończuk, Anna, additional, Kulikowska, Joanna, additional, Kochanowicz, Jan, additional, Białek, Marta, additional, Stolarz, Małgorzata, additional, Kubicka-Bączyk, Katarzyna, additional, Niedziela, Natalia, additional, Warmus, Paweł, additional, Adamczyk-Sowa, Monika, additional, Podlecka-Piçtowska, Aleksandra, additional, Nojszewska, Monika, additional, Zakrzewska-Pniewska, Beata, additional, Jasińska, Elżbieta, additional, Zaborski, Jacek, additional, Milewska-Jȩdrzejczak, Marta, additional, Zwiernik, Jacek, additional, Zwiernik, Beata, additional, Potemkowski, Andrzej, additional, Brola, Waldemar, additional, and Kułakowska, Alina, additional

Published
2022
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18. Safety of Vaccines against SARS-CoV-2 among Polish Patients with Multiple Sclerosis Treated with Disease-Modifying Therapies

Author

Czarnowska, Agata, primary, Tarasiuk, Joanna, additional, Zajkowska, Olga, additional, Wnuk, Marcin, additional, Marona, Monika, additional, Nowak, Klaudia, additional, Słowik, Agnieszka, additional, Jamroz-Wiśniewska, Anna, additional, Rejdak, Konrad, additional, Lech, Beata, additional, Popiel, Małgorzata, additional, Rościszewska-Żukowska, Iwona, additional, Perenc, Adam, additional, Bartosik-Psujek, Halina, additional, Świderek-Matysiak, Mariola, additional, Siger, Małgorzata, additional, Ciach, Agnieszka, additional, Walczak, Agata, additional, Jurewicz, Anna, additional, Stasiołek, Mariusz, additional, Kania, Karolina, additional, Dyczkowska, Klara, additional, Kalinowska-Łyszczarz, Alicja, additional, Galus, Weronika, additional, Walawska-Hrycek, Anna, additional, Krzystanek, Ewa, additional, Chojdak-Łukasiewicz, Justyna, additional, Ubysz, Jakub, additional, Pokryszko-Dragan, Anna, additional, Kapica-Topczewska, Katarzyna, additional, Chorąży, Monika, additional, Bazylewicz, Marcin, additional, Mirończuk, Anna, additional, Kulikowska, Joanna, additional, Kochanowicz, Jan, additional, Białek, Marta, additional, Stolarz, Małgorzata, additional, Kubicka-Bączyk, Katarzyna, additional, Niedziela, Natalia, additional, Morawiec, Natalia, additional, Adamczyk-Sowa, Monika, additional, Podlecka-Piętowska, Aleksandra, additional, Nojszewska, Monika, additional, Zakrzewska-Pniewska, Beata, additional, Jasińska, Elżbieta, additional, Zaborski, Jacek, additional, Milewska-Jędrzejczak, Marta, additional, Zwiernik, Jacek, additional, Zwiernik, Beata, additional, Potemkowski, Andrzej, additional, Brola, Waldemar, additional, and Kułakowska, Alina, additional

Published
2022
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19. The Big Five Personality Traits and Positive Orientation in Polish Adults with Multiple Sclerosis: The Role of Meaning in Life

Author

Szcześniak, Małgorzata, primary, Potemkowski, Andrzej, additional, Brola, Waldemar, additional, Kroplewski, Zdzisław, additional, Szałachowski, Roman Ryszard, additional, Zak, Marek, additional, Wilski, Maciej, additional, Sobolewski, Piotr, additional, Bartosik-Psujek, Halina, additional, Kapica-Topczewska, Katarzyna, additional, Tarasiuk, Joanna, additional, Czarnowska, Agata, additional, Kułakowska, Alina, additional, Zakrzewska-Pniewska, Beata, additional, Kubicka-Bączyk, Katarzyna, additional, Morawiec, Natalia, additional, Adamczyk-Sowa, Monika, additional, Stępień, Adam, additional, Zaborski, Jacek, additional, Ratajczak, Anna, additional, and Ratajczak, Marcin, additional

Published
2022
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21. Antibodies against SARS-CoV-2 S and N proteins in relapsing-remitting multiple sclerosis patients treated with disease-modifying therapies.

Author

Kulikowska, Joanna, Czarnowska, Agata, Gudowska-Sawczuk, Monika, Kulczyńska-Przybik, Agnieszka, Bazylewicz, Marcin, Collins, Francois, Chorąży, Monika, Mroczko, Barbara, Kochanowicz, Jan, Kapica-Topczewska, Katarzyna, and Kułakowska, Alina

Abstract

Clinical rationale for the study. The course of COVID-19 in people with multiple sclerosis (PwMS) has been described, while the serological status after SARS-CoV-2 infection or vaccination, especially in patients treated with disease-modifying therapies (DMT), is still under investigation. This is a significant clinical problem, as certain DMTs may predispose to a severe course of viral infections. Aim of the study. We analyzed the presence of antibodies against spike (S) and nucleocapsid (N) proteins of SARS-CoV-2 in relapsing-remitting PwMS treated with DMT, especially dimethyl fumarate, interferon beta, and glatiramer acetate, in a single multiple sclerosis (MS) centre in north-eastern Poland (the Department of Neurology, Medical University of Bialystok). Material and methods. The presence of antibodies against S and N proteins in PwMS was assessed twice: on visit one (between May and June 2020) (n = 186) and on visit two (between May and June 2021) (n = 88). Samples were taken from 68 individuals on both visits. Demographic and clinical data was collected: duration of MS, Expanded Disability Status Scale Score (EDSS), type of DMT, history of COVID-19 (positive PCR or antigen test in the past), vaccination status, and the type of vaccine. Results. It was shown that on visit one: 3.7% (n = 7) PwMS were positive for IgA against S protein (IgA-S), 3.2% (n = 6) for IgG against S (IgG-S) protein, and none of those examined was positive for IgG against N protein (IgG-N). On visit two, the most common detected antibodies were IgG-S (71.3%; n = 62), then IgA-S (65.1%; n = 55), and the least common was IgG-N (18.2%; n = 16). On visit two: 20.45% of PwMS had a history of a positive SARS-CoV-2 PCR or antigen test during the last year. By the time of visit two, 42.05% (n = 37) of patients who participated in visit two had been full-course vaccinated against COVID-19. It was demonstrated that vaccination against SARS-CoV-2 significantly induces the production of IgG-S and IgA-S (p < 0.0001), while no difference between vaccinated and unvaccinated patients was shown in the detection of IgG-N. There was no correlation between COVID-19 infection and antibodies against proteins S and N in the study group. Moreover, the presented study did not show any relationship between the ability to produce antibodies against the S protein with any of the used DMTs. Conclusions and clinical implications. According to our study, PwMS treated with dimethyl fumarate, interferon beta, or glatiramer acetate can efficiently produce antibodies against SARS-CoV-2 both after infection and after vaccination. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Symptoms after COVID-19 Infection in Individuals with Multiple Sclerosis in Poland

Author

Czarnowska, Agata, primary, Kapica-Topczewska, Katarzyna, additional, Zajkowska, Olga, additional, Adamczyk-Sowa, Monika, additional, Kubicka-Bączyk, Katarzyna, additional, Niedziela, Natalia, additional, Warmus, Paweł, additional, Kalinowska-Łyszczarz, Alicja, additional, Kania, Karolina, additional, Słowik, Agnieszka, additional, Wnuk, Marcin, additional, Marona, Monika, additional, Nowak, Klaudia, additional, Bartosik-Psujek, Halina, additional, Lech, Beata, additional, Perenc, Adam, additional, Popiel, Małgorzata, additional, Kucharska-Lipowska, Marta, additional, Chorąży, Monika, additional, Tarasiuk, Joanna, additional, Mirończuk, Anna, additional, Kochanowicz, Jan, additional, Lasek-Bal, Anetta, additional, Puz, Przemysław, additional, Maciejowska, Katarzyna, additional, Wawrzyniak, Sławomir, additional, Niezgodzińska-Maciejek, Anna, additional, Pokryszko-Dragan, Anna, additional, Gruszka, Ewa, additional, Budrewicz, Sławomir, additional, Białek, Marta, additional, Zwiernik, Jacek, additional, Michałowska, Anna, additional, Nosek, Krzysztof, additional, Zwiernik, Beata, additional, Lewańczyk, Bożena, additional, Brola, Waldemar, additional, and Kułakowska, Alina, additional

Published
2021
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25. Clinical course and outcome of SARS-CoV-2 infection in multiple sclerosis patients treated with disease-modifying therapies — the Polish experience

Author

Czarnowska, Agata, primary, Brola, Waldemar, additional, Zajkowska, Olga, additional, Rusek, Stanisław, additional, Adamczyk-Sowa, Monika, additional, Kubicka-Bączyk, Katarzyna, additional, Kalinowska-Łyszczarz, Alicja, additional, Kania, Karolina, additional, Słowik, Agnieszka, additional, Wnuk, Marcin, additional, Marona, Monika, additional, Podlecka-Piętowska, Aleksandra, additional, Nojszewska, Monika, additional, Zakrzewska-Pniewska, Beata, additional, Jasińska, Elżbieta, additional, Gołuch, Katarzyna, additional, Lech, Beata, additional, Noga, Magdalena, additional, Perenc, Adam, additional, Popiel, Małgorzata, additional, Lasek-Bal, Anetta, additional, Puz, Przemysław, additional, Maciejowska, Katarzyna, additional, Kucharska-Lipowska, Marta, additional, Lipowski, Michał, additional, Kapica-Topczewska, Katarzyna, additional, Chorąży, Monika, additional, Tarasiuk, Joanna, additional, Kochanowicz, Jan, additional, Kulikowska, Joanna, additional, Wawrzyniak, Sławomir, additional, Niezgodzińska-Maciejek, Anna, additional, Pokryszko-Dragan, Anna, additional, Gruszka, Ewa, additional, Budrewicz, Sławomir, additional, Białek, Marta, additional, Kurkowska-Jastrzębska, Iwona, additional, Kurowska, Katarzyna, additional, Stępień, Adam, additional, Włodek, Agata, additional, Ptasznik, Violetta, additional, Pawełczyk, Małgorzata, additional, Sobolewski, Piotr, additional, Lejmel, Henryka, additional, Strzalińska, Katarzyna, additional, Maciejowski, Maciej, additional, Tutaj, Andrzej, additional, Zwiernik, Jacek, additional, Litwin, Anna, additional, Lewańczyk, Bożena, additional, Paprocka, Izabela, additional, Zwiernik, Beata, additional, Pawlos, Aleksandra, additional, Borysowicz, Andrzej, additional, Narożnik, Anna, additional, Michałowska, Anna, additional, Nosek, Krzysztof, additional, Fudala, Małgorzata, additional, Milewska-Jędrzejczak, Marta, additional, Kułakowska, Alina, additional, and Bartosik-Psujek, Halina, additional

Published
2021
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26. Variants of Novel Immunomodulatory Fc Receptor Like 5 Gene Are Associated With Multiple Sclerosis Susceptibility in the Polish Population

Author

Chorazy, Monika, primary, Wawrusiewicz-Kurylonek, Natalia, additional, Adamska-Patruno, Edyta, additional, Czarnowska, Agata, additional, Zajkowska, Olga, additional, Kapica-Topczewska, Katarzyna, additional, Posmyk, Renata, additional, Kretowski, Adam Jacek, additional, Kochanowicz, Jan, additional, and Kułakowska, Alina, additional

Published
2021
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27. Zespół Flammera - charakterystyka i występowanie wśród pacjentów ze stwardnieniem rozsianym.

Author

Pikora, Katarzyna, Jamiołkowska, Joanna, Janosz, Piotr, Betlejewska, Joanna, Warpechowski, Jędrzej, Kapica-Topczewska, Katarzyna, Czarnowska, Agata, Supronik, Anna, Kochanowicz, Jan, and Kułakowska, Alina

Subjects
CALCIUM antagonists, PAIN threshold, NEUROLOGICAL disorders, PERSONALITY, MULTIPLE sclerosis, VERTIGO, EXFOLIATION syndrome
Abstract

Copyright of Current Neurology / Aktualno?ci Neurologiczne is the property of Medical Communications Sp. z o.o. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022
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29. Assessment of anti‐HSV antibodies in patients with facial palsy in the course of neuroborreliosis

Author

Moniuszko‐Malinowska, Anna, primary, Guziejko, Katarzyna, additional, Czarnowska, Agata, additional, Kułakowska, Alina, additional, Zajkowska, Olga, additional, Pancewicz, Sławomir, additional, Świerzbińska, Renata, additional, Dunaj, Justyna, additional, Czupryna, Piotr, additional, Róg‐Makal, Magdalena, additional, and Zajkowska, Joanna, additional

Published
2020
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31. Clinical and epidemiological characteristics of multiple sclerosis patients receiving disease-modifying treatment in Poland

Author

Kapica-Topczewska, Katarzyna, primary, Collin, Francois, additional, Tarasiuk, Joanna, additional, Chorąży, Monika, additional, Czarnowska, Agata, additional, Kwaśniewski, Mirosław, additional, Brola, Waldemar, additional, Bartosik-Psujek, Halina, additional, Adamczyk-Sowa, Monika, additional, Kochanowicz, Jan, additional, and Kułakowska, Alina, additional

Published
2020
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32. Analysis of risk factors and clinical characteristic of stroke patients admitted to the Department of Neurology, Medical University of Bialystok in 2016

Author

Kapica-Topczewska, Katarzyna, primary, Golec, Weronika, additional, Kulikowska, Joanna, additional, Izycki-Herman, Jakub, additional, Gryko, Adam, additional, Wasilewska, Malgorzata, additional, Kowalczyk, Magdalena, additional, Dabrowska, Anna, additional, Wozniak, Weronika, additional, Czarnowska, Agata, additional, Kochanowicz, Jan, additional, and Kulakowska, Alina, additional

Published
2020
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33. John Cunningham Virus Status, Seroconversion Rate, and the Risk of Progressive Multifocal Leukoencephalopathy in Polish John Cunningham Virus-Seronegative Patients with Relapsing-Remitting Multiple Sclerosis

Author

Kapica-Topczewska, Katarzyna, primary, Collin, Francois, additional, Tarasiuk, Joanna, additional, Czarnowska, Agata, additional, Chorąży, Monika, additional, Mirończuk, Anna, additional, Kochanowicz, Jan, additional, and Kułakowska, Alina, additional

Published
2020
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34. Does obesity increase the risk of stroke?

Author

Sajdak, Jacek, primary, Stępień, Dominika, additional, Werel, Paulina, additional, Czarnowska, Agata, additional, Kapica-Topczewska, Katarzyna, additional, and Kułakowska, Alina, additional

Published
2019
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35. The effectiveness of interferon beta versus glatiramer acetate and natalizumab versus fingolimod in a Polish real-world population

Author

Kapica-Topczewska, Katarzyna, primary, Tarasiuk, Joanna, additional, Collin, Francois, additional, Brola, Waldemar, additional, Chorąży, Monika, additional, Czarnowska, Agata, additional, Kwaśniewski, Mirosław, additional, Bartosik-Psujek, Halina, additional, Adamczyk-Sowa, Monika, additional, Kochanowicz, Jan, additional, and Kułakowska, Alina, additional

Published
2019
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36. Level of fibrinogen, D-dimers and C-reactive protein, and correlations between these parameters in ischemic and haemorrhagic stroke.

Author

Warpechowski, Jedrzej Jan, Jamiołkowska, Joanna, Ilnicki, Michał, Michalczuk, Karolina, Czarnowska, Agata, Kulikowska, Joanna, Kapica-Topczewska, Katarzyna, Kochanowicz, Jan, and Kułakowska, Alina

Subjects
FIBRINOGEN, FIBRIN fragment D, C-reactive protein, HEMORRHAGIC fever, ISCHEMIC stroke
Abstract

Copyright of General Medicine & Health Sciences / Medycyna Ogólna i Nauki o Zdrowiu is the property of Witold Chodzki Institute of Rural Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2021
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37. Association between polymorphisms of a folate – homocysteine – methionine – SAM metabolising enzyme gene and multiple sclerosis in a Polish population

Author

Chorąży, Monika, primary, Wawrusiewicz-Kurylonek, Natalia, additional, Gościk, Joanna, additional, Posmyk, Renata, additional, Czarnowska, Agata, additional, Więsik, Marta, additional, Kapica-Topczewska, Katarzyna, additional, Krętowski, Adam Jacek, additional, Kochanowicz, Jan, additional, and Kułakowska, Alina, additional

Published
2018
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38. Assessment of anti‐HSV antibodies in patients with facial palsy in the course of neuroborreliosis.

Author

Moniuszko‐Malinowska, Anna, Guziejko, Katarzyna, Czarnowska, Agata, Kułakowska, Alina, Zajkowska, Olga, Pancewicz, Sławomir, Świerzbińska, Renata, Dunaj, Justyna, Czupryna, Piotr, Róg‐Makal, Magdalena, and Zajkowska, Joanna

Abstract

Aim: There are many causes of facial nerve palsy. The most common causes are neuroborreliosis (NB), idiopathic paralysis or Herpes simplex virus (HSV) reactivation. The aim of this study was to characterize patients with facial palsy in the course of NB and to determine whether HSV‐1 reactivation takes place during the acute phase of NB. Methods: A retrospective analysis of 66 patients with facial nerve palsy was performed. In 38 patients, facial palsy was caused by Borrelia burgdorferi sl infection. Immunological tests for HSV‐1, tick‐borne encephalitis virus and B burgdorferi sl in serum and cerebrospinal fluid (CSF) were performed. Results: In this analysis, 55.2% of NB patients had right nerve palsy and 21% bilateral palsy; 15.8% of patients had erythema migrans (EM). Lymphocytic meningitis was diagnosed in 92% of patients and Bannwarth's syndrome was diagnosed in 47% of patients. IgM anti‐HSV‐1 antibodies were detected in four patients with NB and two patients with facial nerve palsy of other origin. IgM anti‐HSV‐1 antibodies were detected in the CSF of three patients (7.9%) with NB, and one of them had bilateral VII paresis and EM simultaneously. Treatment with ceftriaxone or doxycycline led to complete recovery. Conclusions: Neuroborreliosis should always be considered as a cause of peripheral facial nerve palsy. Peripheral facial nerve palsy is a significant symptom in the course of NB, especially in patients accompanied by meningitis. Pathomechanism of facial nerve paresis has not been well explained so far and may depend on two independent mechanisms in NB, including HSV‐1 reactivation. [ABSTRACT FROM AUTHOR]

Published
2021
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39. Ischaemic stroke caused by spontaneous unilateral carotid artery dissection in patient with connective tissue disorder.

Author

Pużyńska, Weronika, Mirończuk, Anna, Kapica-Topczewska, Katarzyna, Łukasiewicz, Adam, Czarnowska, Agata, Kochanowicz, Jan, and Kułakowska, Alina

Subjects
ISCHEMIC stroke, CAROTID artery dissections, STROKE, CONNECTIVE tissues, ARTERIAL dissections, MEDICAL personnel, EHLERS-Danlos syndrome
Abstract

Copyright of Current Neurology / Aktualno?ci Neurologiczne is the property of Medical Communications Sp. z o.o. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2021
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40. Body mass index, waist-to-hip ratio, and body surface area in patients with acute ischaemic stroke in north-eastern Poland.

Author

Czarnowska, Agata, Werel, Paulina, Stępień, Dominika, Sajdak, Jacek, Stelmaszek, Justyna, Zajkowska, Olga, Kapica-Topczewska, Katarzyna, and Kułakowska, Alina

Subjects
WAIST-hip ratio, ISCHEMIC stroke, BODY mass index, BODY surface area, HOSPITAL admission & discharge
Abstract

Copyright of Current Neurology / Aktualno?ci Neurologiczne is the property of Medical Communications Sp. z o.o. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2020
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42. Antibodies against SARS-CoV-2 S and N proteins in relapsing-remitting multiple sclerosis patients treated with disease-modifying therapies.

Author

Kulikowska J, Czarnowska A, Gudowska-Sawczuk M, Kulczyńska-Przybik A, Bazylewicz M, Collins F, Chorąży M, Mroczko B, Kochanowicz J, Kapica-Topczewska K, and Kułakowska A

Subjects
Humans, SARS-CoV-2, Glatiramer Acetate therapeutic use, Dimethyl Fumarate therapeutic use, Interferon-beta, N,N-Dimethyltryptamine, Immunoglobulin A, Immunoglobulin G, Antibodies, Viral, Multiple Sclerosis, Relapsing-Remitting drug therapy, Multiple Sclerosis, COVID-19
Abstract

Clinical Rationale for the Study: The course of COVID-19 in people with multiple sclerosis (PwMS) has been described, while the serological status after SARS-CoV-2 infection or vaccination, especially in patients treated with disease-modifying therapies (DMT), is still under investigation. This is a significant clinical problem, as certain DMTs may predispose to a severe course of viral infections., Aim of the Study: We analyzed the presence of antibodies against spike (S) and nucleocapsid (N) proteins of SARS-CoV-2 in relapsing-remitting PwMS treated with DMT, especially dimethyl fumarate, interferon beta, and glatiramer acetate, in a single multiple sclerosis (MS) centre in north-eastern Poland (the Department of Neurology, Medical University of Bialystok)., Material and Methods: The presence of antibodies against S and N proteins in PwMS was assessed twice: on visit one (between May and June 2020) (n = 186) and on visit two (between May and June 2021) (n = 88). Samples were taken from 68 individuals on both visits. Demographic and clinical data was collected: duration of MS, Expanded Disability Status Scale Score (EDSS), type of DMT, history of COVID-19 (positive PCR or antigen test in the past), vaccination status, and the type of vaccine., Results: It was shown that on visit one: 3.7% (n = 7) PwMS were positive for IgA against S protein (IgA-S), 3.2% (n = 6) for IgG against S (IgG-S) protein, and none of those examined was positive for IgG against N protein (IgG-N). On visit two, the most common detected antibodies were IgG-S (71.3%; n = 62), then IgA-S (65.1%; n = 55), and the least common was IgG-N (18.2%; n = 16). On visit two: 20.45% of PwMS had a history of a positive SARS-CoV-2 PCR or antigen test during the last year. By the time of visit two, 42.05% (n = 37) of patients who participated in visit two had been full-course vaccinated against COVID-19. It was demonstrated that vaccination against SARS-CoV-2 significantly induces the production of IgG-S and IgA-S (p < 0.0001), while no difference between vaccinated and unvaccinated patients was shown in the detection of IgG-N. There was no correlation between COVID-19 infection and antibodies against proteins S and N in the study group. Moreover, the presented study did not show any relationship between the ability to produce antibodies against the S protein with any of the used DMTs., Conclusions and Clinical Implications: According to our study, PwMS treated with dimethyl fumarate, interferon beta, or glatiramer acetate can efficiently produce antibodies against SARS-CoV-2 both after infection and after vaccination.

Published
2023
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43. Association between polymorphisms of a folate - homocysteine - methionine - SAM metabolising enzyme gene and multiple sclerosis in a Polish population.

Author

Chorąży M, Wawrusiewicz-Kurylonek N, Gościk J, Posmyk R, Czarnowska A, Więsik M, Kapica-Topczewska K, Krętowski AJ, Kochanowicz J, and Kułakowska A

Subjects
Adult, Female, Folic Acid, Gene Frequency, Genotype, Homocysteine, Humans, Male, Methionine, Methylenetetrahydrofolate Reductase (NADPH2), Poland, Multiple Sclerosis
Abstract

Background and Objectives: Multiple sclerosis (MS) is a chronic inflammatory, autoimmune disease with a still unknown aetiology. The main initial mechanism of demyelination and injury to the central nervous system (CNS) appears to be inflammation. Neurotoxicity induced by homocysteine (Hcy) may be a factor affecting this process. 5,10-methylenetetrahydrofolate reductase (MTHFR) is an essential enzyme involved in Hcy metabolism. It leads to Hcy remethylation to methionine. In the present study, we aimed to investigate a possible association between two variants of MTHFR gene in patients with MS in Poland and healthy individuals., Methods: In this study, we genotyped 174 relapsing-remitting MS patients and 186 healthy controls using the TaqMan technique., Results and Conclusions: It was found that, regardless of the presence of a specific allele, the gender of MS patients affects age at the time of the clinical onset of the disease: in rs1801133 for the C allele and T, the average age was 35 years for women and 29 for men (p = 0.0004; p = 0.034 respectively). Similarly for the second polymorphism rs1801131 for the A allele and C, the average age was 35 years for women and 29 for men (p = 0.001; p = 0.01 respectively). No significant allelic / genotypic frequency differences have been observed between the studied groups (c.677C > T, CT/TT p = 0.719, p = 0.262; c.1298A > C, AC/CC of p = 0.686; p = 0.66). We found no association between polymorphisms of a folate-homocysteine-methionine-SAM metabolising gene enzyme and multiple sclerosis in a Polish population.

Published
2019
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