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2. Relevance of Higher-Order Epistasis in Drug Resistance

Author

Gavin D. Heffernan, David P. Jacobus, Rachel F. Daniels, Daniel L. Hartl, and Elena R. Lozovsky

Subjects
epistasis, Combination therapy, Plasmodium falciparum, Adaptation, Biological, Drug Resistance, Saccharomyces cerevisiae, Drug resistance, Biology, AcademicSubjects/SCI01180, Evolution, Molecular, 03 medical and health sciences, 0302 clinical medicine, dihydrofolate reductase, Dihydrofolate reductase, Genetics, medicine, Artemisinin, Molecular Biology, Discoveries, Alleles, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology, 0303 health sciences, AcademicSubjects/SCI01130, Epistasis, Genetic, biology.organism_classification, drug development, Tetrahydrofolate Dehydrogenase, Pyrimethamine, Drug development, triazine antifolates, adaptive topography, biology.protein, Folic Acid Antagonists, Epistasis, Genetic Fitness, 030217 neurology & neurosurgery, medicine.drug
Abstract

We studied five chemically distinct but related 1,3,5-triazine antifolates with regard to their effects on growth of a set of mutants in dihydrofolate reductase. The mutants comprise a combinatorially complete data set of all 16 possible combinations of four amino acid replacements associated with resistance to pyrimethamine in the malaria parasite Plasmodium falciparum. Pyrimethamine was a mainstay medication for malaria for many years, and it is still in use in intermittent treatment during pregnancy or as a partner drug in artemisinin combination therapy. Our goal was to investigate the extent to which the alleles yield similar adaptive topographies and patterns of epistasis across chemically related drugs. We find that the adaptive topographies are indeed similar with the same or closely related alleles being fixed in computer simulations of stepwise evolution. For all but one of the drugs the topography features at least one suboptimal fitness peak. Our data are consistent with earlier results indicating that third order and higher epistatic interactions appear to contribute only modestly to the overall adaptive topography, and they are largely conserved. In regard to drug development, our data suggest that higher-order interactions are likely to be of little value as an advisory tool in the choice of lead compounds.

Published
2020
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4. Regioisomerization of Antimalarial Drug WR99210 Explains the Inactivity of a Commercial Stock

Author

T. Parks Remcho, Carole A. Bewley, Phillip Cruz, Gavin D. Heffernan, Thomas E. Wellems, Glenn Nardone, Kristin D. Lane, Robert D. O’Connor, and Sravanthi D. Guggilapu

Subjects
Stereochemistry, Plasmodium falciparum, Drug Resistance, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, Antimalarials, Dihydrofolate reductase, Structural isomer, Humans, Pharmacology (medical), Phosphofructokinase 2, Malaria, Falciparum, 030304 developmental biology, Pharmacology, 0303 health sciences, biology, Chemistry, Triazines, Active site, Nuclear magnetic resonance spectroscopy, Thymidylate Synthase, Biosynthesis, biology.organism_classification, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Tetrahydrofolate Dehydrogenase, Infectious Diseases, Docking (molecular), biology.protein, Folic Acid Antagonists, Thymidine
Abstract

WR99210, a former antimalarial drug candidate now widely used for the selection of Plasmodium transfectants, selectively targets the parasite’s dihydrofolate reductase thymidine synthase bifunctional enzyme (DHFR-TS) but not human DHFR, which is not fused with TS. Accordingly, WR99210 and plasmids expressing the human dhfr gene have become valued tools for the genetic modification of parasites in the laboratory. Concerns over the ineffectiveness of WR99210 from some sources encouraged us to investigate the biological and chemical differences of supplies from two different companies (compounds 1 and 2). Compound 1 proved effective at low nanomolar concentrations against Plasmodium falciparum parasites, whereas compound 2 was ineffective, even at micromolar concentrations. Intact and fragmented mass spectra indicated identical molecular formulae of the unprotonated (free base) structures of compounds 1 and 2; however, the compounds displayed differences by thin-layer chromatography, reverse-phase high-performance liquid chromatography, and UV-visible spectroscopy, indicating important isomeric differences. Structural evaluations by (1)H, (13)C, and (15)N nuclear magnetic resonance spectroscopy confirmed compound 1 as WR99210 and compound 2 as a dihydrotriazine regioisomer. Induced fit computational docking models showed that compound 1 binds tightly and specifically in the P. falciparum DHFR active site, whereas compound 2 fits poorly to the active site in loose and varied orientations. Stocks and concentrates of WR99210 should be monitored for the presence of regioisomer 2, particularly when they are not supplied as the hydrochloride salt or are exposed to basic conditions that may promote rearrangement. Absorption spectroscopy can serve for assays of the unrearranged and rearranged triazines.

Published
2020

5. Isomerization of antimalarial drug WR99210 explains its inactivity in a commercial stock

Author

Sravanthi D. Guggilapu, Thomas E. Wellems, Glenn Nardone, Robert D. O’Connor, T. Parks Remcho, Carole A. Bewley, Kristin D. Lane, Phillip Cruz, and Gavin D. Heffernan

Subjects
biology, Chemistry, Stereochemistry, Active site, Plasmodium falciparum, Nuclear magnetic resonance spectroscopy, biology.organism_classification, Thin-layer chromatography, chemistry.chemical_compound, Docking (molecular), Dihydrofolate reductase, biology.protein, Thymidine, Isomerization
Abstract

WR99210, a former antimalarial drug candidate now widely used for the selection of Plasmodium transfectants, selectively targets the parasite dihydrofolate reductase thymidine synthase bifunctional enzyme (DHFR-TS) but not human DHFR, which is not fused with TS. Accordingly, WR99210 and plasmids expressing human dhfr have become valued tools for the genetic modification of parasites in the laboratory. Concerns over the ineffectiveness of WR99210 from some sources encouraged us to investigate the biological and chemical differences of supplies from two different companies (compounds 1 and 2). Compound 1 proved effective at low nanomolar concentrations against Plasmodium falciparum parasites, whereas compound 2 was ineffective even at micromolar concentrations. Intact and fragmented mass spectra indicated identical molecular formulae of the unprotonated (free base) structures of 1 and 2; however, the compounds displayed differences by thin layer chromatography, reverse phase high performance liquid chromatography, and ultraviolet-visible spectroscopy, indicating important isomeric differences. Structural evaluations by 1H, 13C, and 15N nuclear magnetic resonance spectroscopy confirmed 1 as WR99210 and 2 as an isomeric dihydrotriazine. Induced fit, computational docking models showed that 1 binds tightly and specifically in the P. falciparum DHFR active site whereas 2 fits poorly to the active site in loose and varied orientations. Stocks and concentrates of WR99210 should be monitored for the presence of isomer 2, particularly when they are not supplied as the hydrochloride salt or are exposed to basic conditions that can promote isomerization. Absorption spectroscopy may serve for assays of the unrearranged and rearranged triazines.

Published
2020
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8. NeuroSAFE PROOF. Update on a multi-centre, pragmatic, RCT for men undergoing robot-assisted radical prostatectomy: Trial in progress

Author

D. Heffernan-Ho, Norman R. Williams, J. Salmond, Tim Briggs, Senthil Nathan, S. Mallett, Jonathan Aning, Clare Allen, Jon Oxley, I. Ben-Salha, S. Morgan, Greg Shaw, Jack Grierson, Rajendra Persad, Imran Ahmad, Chris Brew-Graves, R. Clow, Eoin Dinneen, Aiman Haider, Alex Freeman, Lorenzo Dutto, R. Marzena, J. Kelly, F. Tahir, and Neil Oakley

Subjects
medicine.medical_specialty, Randomized controlled trial, law, Prostatectomy, business.industry, Urology, medicine.medical_treatment, Physical therapy, medicine, Robot, Multi centre, business, law.invention
Published
2021
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9. Measurement of the Michel parameters (η‾, ξκ ) in the radiative leptonic decay of τ

Author

J. E. Fast, D. Dossett, M. Niiyama, L. Pesántez, V. Trusov, Andrey Sokolov, S. Shinomiya, Byeong Rok Ko, M. Feindt, I. Nakamura, V. Babu, Hui Li, Jingxu Wang, T. Aushev, O. Frost, Z. Suzuki, J. Grygier, J. H. Kang, Y. Miyachi, Hikaru Kawai, M. Belhorn, Benjamin Schwenker, T. Zivko, Y. B. Hsiung, K. Neichi, A. Zupanc, C. C. Zhang, E. Nakano, Antonio Limosani, T. Ferber, D. H. Lee, H. Kakuno, H. Shibuya, M. Watanabe, L. S. Peak, C. Niebuhr, O. Nitoh, K. Nishimura, Chawon Park, A. Loos, J. C. Dingfelder, M. V. Purohit, P. Goldenzweig, Rupert Leitner, V. V. Zhulanov, J. Yamaoka, Xiuwan Li, K. Senyo, S. Eidelman, L. Shang, Ihn Sik Seong, S. Sandilya, K. Ueno, M. Heck, M. J. Kim, T. Kawasaki, P. Pakhlov, W. Ostrowicz, U. Tamponi, Anton Poluektov, T. Schlüter, S. Sugihara, M. Starič, Y. Igarashi, M. Masuda, Dipanwita Dutta, A. Sugiyama, T. Kumita, M. Uchida, X. H. He, D. Cinabro, Philip Lewis, G. B. Mohanty, C. H. Li, Massimo Berger, B. H. Kim, Y. Yook, H. Yamamoto, L. K. Li, V.N. Zhilich, Y. Kato, V. Chobanova, Y. Kuroki, Satoshi Tanaka, D. Liventsev, Y. Arita, I. Jaegle, K. Miyabayashi, M. Lubej, G. Inguglia, I. Badhrees, Y. Koga, E. Nedelkovska, F. Breibeck, H. Park, J. Stypula, C. Kiesling, E. J. White, A. Bozek, P. Chang, G. S. Varner, Y.-T. Lai, K. Suzuki, P. Schonmeier, M. Iwabuchi, R. Mussa, H. B. Jeon, O. Grzymkowska, C. H. Wang, M. Grosse Perdekamp, R. Itoh, Jung-Hyun Kim, S. Wehle, T. Keck, S. Paul, L. Li Gioi, Y. Yamashita, C. Z. Yuan, Yukinori Sato, J. G. Shiu, M. Nayak, T. Bloomfield, A. Ishikawa, A. Drutskoy, S. E. Vahsen, A. Bay, C.-L. Hsu, T. Saito, S. Rummel, T. Matsuda, Yu Nakahama, M. Tanaka, T. Peng, G. Schnell, A. Rostomyan, Tsukasa Aso, P. Wang, H. Miyata, Y. Hoshi, M. Barrett, B. Bhuyan, Y.L. Han, A. Frey, H. Ye, P. Križan, T. Iijima, Jun Sasaki, H. G. Moser, M. Bračko, Y. Iwasaki, B. G. Fulsom, Peter Kodys, W. W. Jacobs, T. E. Browder, Y. J. Kwon, K. Nakamura, Ya-Qiu Jin, P. Hamer, K. Hayasaka, A. Bobrov, H. Hayashii, Hyunyong Kim, O. Schneider, K. Prasanth, M. Imamura, T. Nagamine, K. Trabelsi, P. Katrenko, T. Müller, J. Klucar, K. T. Kim, C. P. Shen, S. Di Carlo, Seok Kim, S. Okuno, B. Shwartz, Jamal Rorie, D. Getzkow, C. B. Van Hulse, I. Adachi, A. Ogawa, K. Negishi, T. Kuhr, D. Z. Besson, E. Ribežl, D. Santel, Phillip Urquijo, N. Sasao, Victoria Zhukova, V. Savinov, M. Danilov, H. Nakayama, D. Y. Kim, R. Gillard, R. Mizuk, Eberhard Widmann, J. F. Strube, Matthew Jones, M. Z. Wang, K. Kinoshita, M. Yamauchi, G. Bonvicini, Y. B. Li, Y. Teramoto, I. Tikhomirov, D. Mohapatra, J. B. Singh, A. Chen, K. Hara, S. K. Choi, Sanmay Ganguly, T. Uchida, Y. Ban, N. Zwahlen, Bruce Yabsley, L. Zhao, M. Heider, M. Rozanska, D. Kotchetkov, Y. Yusa, A. Vinokurova, S. Dubey, Rahul Kumar, J. Libby, R. Louvot, Y. Chao, G. N. Taylor, R. Glattauer, V.E. Shebalin, J. Haba, W. Bartel, S. Nishida, S. Al Said, K. Hoshina, Y. Seino, Y. Onuki, K. Vervink, Z. Drásal, Marko Petrič, M. T. Prim, K. Itagaki, Z. Q. Liu, C. Bookwalter, B. G. Cheon, H. J. Hyun, S. Uozumi, P. Smerkol, Tariq Aziz, X. L. Wang, D. Heffernan, T. Morii, C. Boulahouache, J. Hasenbusch, V. Chekelian, J. Li, V. M. Aulchenko, H. Guo, T.-A. Shibata, T. Horiguchi, Y. Ono, S. Koblitz, Seema Bahinipati, Y. Choi, H. Takeichi, K. J. Nath, S. Uno, C. Schwanda, P. Krokovny, M. T. Hedges, Samo Stanič, L.M. Zhang, E. Kurihara, A.E. Bondar, P.A. Lukin, T. Nakano, K. Dutta, A. Garmash, Daniel Greenwald, M. Takizawa, B. Reisert, Y. Sakai, J. Rauch, B. K. Pal, E. L. Barberio, M. Shapkin, Noritaka Shimizu, T. Hara, L. Santelj, J. Dalseno, Robin Wedd, K. M. Williams, V. Bansal, K. Belous, A. M. Bakich, S. Korpar, Jolanta Brodzicka, John Yelton, T. Ohshima, Z. Doležal, K. Chilikin, Y. J. Kim, N. Dash, S. Iwata, H. Ozaki, H. Nakano, C. Ng, K. H. Kang, K. Cho, K. Inami, M. Sumihama, A. Heller, M. D. Peters, Motoki Iwasaki, Y. Ushiroda, N. Taniguchi, Y. M. Goh, S. H. Lee, K. Prothmann, R. Pestotnik, N. Gabyshev, D. Červenkov, A. Abdesselam, M. Steder, M. E. Sevior, I. S. Lee, D. Matvienko, Y. Miyazaki, R. Sinha, P. K. Behera, Yasushi Nagasaka, B. Kronenbitter, Sumio Yamada, E. Kato, M. Leitgab, Tao Luo, K. Tanida, F. Tenchini, T. Sumiyoshi, A. Bala, D. Epifanov, Soumya D. Mohanty, C. Pulvermacher, Martin Ritter, Dmytro Levit, Z. Natkaniec, S. L. Blyth, T. Sanuki, Shigeki Hirose, K. K. Joo, Hirokazu Miyake, R. Seidl, Y. Guan, E. Solovieva, Norihito Muramatsu, M. Huschle, K. Sakai, Y. Watanabe, S. K. Kim, A.L. Sibidanov, H. Kichimi, M. C. Chang, K. S. Park, V. Bhardwaj, T. K. Pedlar, T. Tsuboyama, H. Palka, L. E. Piilonen, G. Pakhlova, J. Wiechczynski, R. Kulasiri, S. U. Kataoka, S. Yashchenko, A. Moll, S. L. Olsen, D. Joffe, T. Julius, Po-Hsun Chen, R. Chistov, A. Vossen, O. Seon, Frank Simon, D. Semmler, Y. Unno, K. F. Chen, R. Ayad, T. Nozaki, S. Uehara, M. N. Wagner, Peter Kvasnicka, A. B. Kaliyar, Sunmin Ryu, C. W. Park, E. Won, C. Oswald, H. Atmacan, P. Vanhoefer, E. Panzenböck, B. Golob, M. Schram, N. K. Nisar, H. K. Moon, J. S. Lange, M. Ziegler, K. Adamczyk, Y. Soloviev, W. S. Hou, K. Arinstein, Y. Mikami, Alexei Kuzmin, V. Vorobyev, Nagao Kobayashi, Y. F. Liu, C. Kleinwort, Z. P. Zhang, H. Sahoo, Tara Nanut, T. Uglov, Yoji Hasegawa, S. Y. Suzuki, Richard T. Kouzes, K. Sumisawa, D. M. Asner, S. Himori, Kevin Varvell, A. Matyja, Jason Crnkovic, T. Mori, H. Aihara, Y. Usov, Jyoti Prakash Biswal, C. Liu, H. Nakazawa, A. J. Schwartz, H. Farhat, J. B. Kim, T. Higuchi, S. Ogawa, V. Gaur, Y. S. Sohn, Ferdinando Giordano, M. Nakao, E. Waheed, S. McOnie, J. MacNaughton, and P. Kapusta

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, 010308 nuclear & particles physics, Maximum likelihood, Electron–positron annihilation, 01 natural sciences, law.invention, Nuclear physics, KEKB, law, 0103 physical sciences, Radiative transfer, Michel parameters, Statistical analysis, 010306 general physics, Collider, Lepton
Abstract

We present the first measurement of the Michel parameters η ‾ and ξκ in the radiative leptonic decay of the τ lepton using 703 fb-1 of data collected with the Belle detector at the KEKB e + e − collider. The Michel parameters are measured by an unbinned maximum likelihood fit to the kinematic information of e + e − → τ + τ − → ( π + π 0 ν ‾ ) ( l − ν ν ‾ γ ) ( l = e or μ ) . The preliminary values of the measured Michel parameters are η ‾ = − 2.0 ± 1.5 ± 0.8 and ξ κ = 0.6 ± 0.4 ± 0.2 , where the first error is statistical and the second is systematic.

Published
2017
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10. In Vivo Efficacy and Pharmacokinetics of the 2-Aminomethylphenol Antimalarial JPC-3210 in the Aotus Monkey-Human Malaria Model

Author

Marina Chavchich, David P. Jacobus, Karin van Breda, Geoffrey W. Birrell, Gavin D. Heffernan, Michael D. Edstein, Dennis Shanks, Nicanor Obaldia, Fiona J. McCallum, and Ivor Harris

Subjects
Pharmacology, 0303 health sciences, biology, 030306 microbiology, business.industry, Plasmodium vivax, Plasmodium falciparum, medicine.disease, biology.organism_classification, Single oral dose, 03 medical and health sciences, Infectious Diseases, Pharmacokinetics, In vivo, Susceptibility, parasitic diseases, medicine, Potency, Pharmacology (medical), business, Malaria, 030304 developmental biology
Abstract

Nonimmune Aotus monkeys infected with Plasmodium falciparum and Plasmodium vivax were cured of their infections when treated with a single oral dose of 5 mg/kg and 10 mg/kg of the 2-aminomethylphenol, JPC-3210, respectively. Corresponding mean blood elimination half-lives of JPC-3210 were lengthy at 19.1 days and 20.5 days, respectively. This in vivo potency and lengthy half-life supports the further development of JPC-3210 as a promising, long-acting blood schizontocidal antimalarial for malaria treatment and prevention.

Published
2020

11. Multi-omic Characterization of the Mode of Action of a Potent New Antimalarial Compound, JPC-3210, Against Plasmodium falciparum

Author

Geoffrey W. Birrell, Gavin D. Heffernan, Darren J. Creek, Dovile Anderson, David P. Jacobus, Michael D. Edstein, Amanda De Paoli, Matthew P. Challis, Shane M. Devine, and Ghizal Siddiqui

Subjects
Proteomics, Quantitative proteomics, Plasmodium falciparum, Protozoan Proteins, Pharmacology, Biochemistry, Analytical Chemistry, 03 medical and health sciences, Antimalarials, Hemoglobins, Phenols, Chloroquine, medicine, Metabolomics, Artemisinin, Mode of action, Molecular Biology, 030304 developmental biology, 0303 health sciences, biology, Chemistry, Mefloquine, Hemozoin, Research, 030302 biochemistry & molecular biology, biology.organism_classification, Peptides, medicine.drug
Abstract

The increasing incidence of antimalarial drug resistance to the first-line artemisinin combination therapies underpins an urgent need for new antimalarial drugs, ideally with a novel mode of action. The recently developed 2-aminomethylphenol, JPC-3210, (MMV 892646) is an erythrocytic schizonticide with potent in vitro antimalarial activity against multidrug-resistant Plasmodium falciparum lines, low cytotoxicity, potent in vivo efficacy against murine malaria, and favorable preclinical pharmacokinetics including a lengthy plasma elimination half-life. To investigate the impact of JPC-3210 on biochemical pathways within P. falciparum-infected red blood cells, we have applied a "multi-omics" workflow based on high resolution orbitrap mass spectrometry combined with biochemical approaches. Metabolomics, peptidomics and hemoglobin fractionation analyses revealed a perturbation in hemoglobin metabolism following JPC-3210 exposure. The metabolomics data demonstrated a specific depletion of short hemoglobin-derived peptides, peptidomics analysis revealed a depletion of longer hemoglobin-derived peptides, and the hemoglobin fractionation assay demonstrated decreases in hemoglobin, heme and hemozoin levels. To further elucidate the mechanism responsible for inhibition of hemoglobin metabolism, we used in vitro β-hematin polymerization assays and showed JPC-3210 to be an intermediate inhibitor of β-hematin polymerization, about 10-fold less potent then the quinoline antimalarials, such as chloroquine and mefloquine. Further, quantitative proteomics analysis showed that JPC-3210 treatment results in a distinct proteomic signature compared with other known antimalarials. While JPC-3210 clustered closely with mefloquine in the metabolomics and proteomics analyses, a key differentiating signature for JPC-3210 was the significant enrichment of parasite proteins involved in regulation of translation. These studies revealed that the mode of action for JPC-3210 involves inhibition of the hemoglobin digestion pathway and elevation of regulators of protein translation. Importantly, JPC-3210 demonstrated rapid parasite killing kinetics compared with other quinolones, suggesting that JPC-3210 warrants further investigation as a potentially long acting partner drug for malaria treatment.

Published
2019

16. Characterization of the Preclinical Pharmacology of the New 2-Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention

Author

David P. Jacobus, Donna Mackenzie, Arba L. Ager, Gavin D. Heffernan, Pablo Rafael Morales, Karin van Breda, Laura R. Jacobus, John W. Anderson, G. Dennis Shanks, Guy A. Schiehser, Michael D. Edstein, Geoffrey W. Birrell, and Marina Chavchich

Subjects
0301 basic medicine, Male, 030106 microbiology, Glucuronidation, Pharmacology, 03 medical and health sciences, Antimalarials, Mice, Pharmacokinetics, Cytochrome P-450 Enzyme System, In vivo, Animals, Humans, Pharmacology (medical), Cells, Cultured, biology, CYP3A4, Chemistry, Cytochrome P450, Plasmodium falciparum, biology.organism_classification, In vitro, Drug Resistance, Multiple, Bioavailability, Malaria, Rats, 030104 developmental biology, Infectious Diseases, biology.protein, Hepatocytes, Microsomes, Liver, Female, Protein Binding
Abstract

The new 2-aminomethylphenol, JPC-3210, has potent in vitro antimalarial activity against multidrug-resistant Plasmodium falciparum lines, low cytotoxicity, and high in vivo efficacy against murine malaria. Here we report on the pharmacokinetics of JPC-3210 in mice and monkeys and the results of in vitro screening assays, including the inhibition of cytochrome P450 (CYP450) isozymes. In mice, JPC-3210 was rapidly absorbed and had an extensive tissue distribution, with a brain tissue-to-plasma concentration ratio of about 5.4. JPC-3210 had a lengthy plasma elimination half-life of about 4.5 days in mice and 11.8 days in monkeys. JPC-3210 exhibited linear single-oral-dose pharmacokinetics across the dose range of 5 to 40 mg/kg of body weight with high oral bioavailability (∼86%) in mice. Systemic blood exposure of JPC-3210 was 16.6% higher in P. berghei -infected mice than in healthy mice. In vitro studies with mice and human hepatocytes revealed little metabolism and the high metabolic stability of JPC-3210. The abundance of human metabolites from oxidation and glucuronidation was 2.0% and 2.5%, respectively. CYP450 studies in human liver microsomes showed JPC-3210 to be an inhibitor of CYP2D6 and, to a lesser extent, CYP3A4 isozymes, suggesting the possibility of a metabolic drug-drug interaction with drugs that are metabolized by these isozymes. In vitro studies showed that JPC-3210 is highly protein bound to human plasma (97%). These desirable pharmacological findings of a lengthy blood elimination half-life, high oral bioavailability, and low metabolism as well as high in vivo potency have led the Medicines for Malaria Venture to select JPC-3210 (MMV892646) for further advanced preclinical development.

Published
2018

17. The NeuroSAFE RCT Feasibility Study

Author

Rajendra Persad, Timothy W. R. Briggs, Clare Allen, N. Oakley, A. Haider, Senthil Nathan, Jack Grierson, D. Heffernan-Ho, A. Freeman, Eoin Dinneen, and Greg Shaw

Subjects
medicine.medical_specialty, Randomized controlled trial, business.industry, law, Urology, Physical therapy, Medicine, business, law.invention
Published
2019
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18. Lead Selection of a New Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention

Author

Arba L. Ager, Michael D. Edstein, Marina Chavchich, Geoffrey W. Birrell, David P. Jacobus, Laura R. Jacobus, G. Dennis Shanks, Guy A. Schiehser, Donna Mackenzie, and Gavin D. Heffernan

Subjects
0301 basic medicine, Pyridines, 030231 tropical medicine, 030106 microbiology, Plasmodium falciparum, Pharmacology, Cell Line, 03 medical and health sciences, Pyrimidine analogue, chemistry.chemical_compound, Antimalarials, Mice, 0302 clinical medicine, Phenols, In vivo, Cricetinae, parasitic diseases, medicine, Animals, Humans, Pharmacology (medical), Malaria, Falciparum, Trifluoromethyl, biology, Mefloquine, Hep G2 Cells, medicine.disease, biology.organism_classification, In vitro, Malaria, Infectious Diseases, HEK293 Cells, chemistry, Susceptibility, Lead compound, medicine.drug
Abstract

Structure-activity relationship studies of trifluoromethyl-substituted pyridine and pyrimidine analogues of 2-aminomethylphenols (JPC-2997, JPC-3186, and JPC-3210) were conducted for preclinical development for malaria treatment and/or prevention. Of these compounds, JPC-3210 [4-( tert -butyl)-2-(( tert -butylamino)methyl)-6-(5-fluoro-6-(trifluoromethyl)pyridin-3-yl)phenol] was selected as the lead compound due to superior in vitro antimalarial activity against multidrug-resistant Plasmodium falciparum lines, lower in vitro cytotoxicity in mammalian cell lines, longer plasma elimination half-life, and greater in vivo efficacy against murine malaria.

Published
2016

19. Predicting the predictable: What can we learn from preoperative mpMRI?

Author

Alex Kirkham, O. Alkadhi, D. Heffernan Ho, N. Pavan, Senthil Nathan, Louise Dickinson, James Thompson, Timothy W. R. Briggs, Clare Allen, D. Gu, J. Kelly, Prasanna Sooriakumaran, Ashwin Sridhar, and G. Mazzon

Subjects
medicine.medical_specialty, business.industry, Urology, Medicine, Medical physics, business
Published
2018
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20. Search for lepton-flavor-violating τ decay into a lepton and an f0(980) meson

Author

M. Tanaka, I. Adachi, O. Nitoh, H. Kaji, D. Heffernan, Y. Watanabe, T. Iijima, Rakesh Kumar, D. H. Kah, H. Aihara, Y. Sakai, D. Epifanov, H. Kawai, B. G. Cheon, B. Shwartz, E. Nakano, Kazuhiko Hara, F. Mandl, Vladimir Zhulanov, K. Senyo, T. Zivko, J. Haba, C. P. Shen, L. E. Piilonen, T. Kawasaki, S. Uehara, Y. Choi, H. Ha, A. Bondar, Z. P. Zhang, H. O. Kim, S. Korpar, Y. Usuki, S. Okuno, M. Bračko, O. Zyukova, J. Dalseno, T. Aushev, H. Miyata, D. Liventsev, Y. Hoshi, M. Dash, M. Starič, J. G. Shiu, Y. Teramoto, A. Drutskoy, K. Inami, Bruce Yabsley, A. M. Bakich, T. Ohshima, Tatiana Medvedeva, G. S. Varner, S. Uno, K. Hayasaka, N. Gabyshev, H. Kichimi, T. Sumiyoshi, A. Vinokurova, M. Nakao, P. Wang, I. S. Cho, S. McOnie, Motoki Iwasaki, Yasuyuki Horii, G. N. Taylor, P. Krokovny, Y. Unno, H. Sahoo, Y. Iwasaki, R. Louvot, Anton Poluektov, T. Uglov, O. Schneider, P. Goldenzweig, C. H. Wang, H. Hayashii, H. K. Park, E. Won, Y. Yamashita, Samo Stanič, A. Kuzmin, V.N. Zhilich, M. Shapkin, Y. J. Kim, S. Ogawa, H. Ozaki, T. Nagamine, S. H. Kyeong, W. S. Hou, K. Arinstein, Y. Yusa, R. Pestotnik, A. Ishikawa, A. Bay, C. W. Park, P. Križan, H. Nakazawa, I. Bedny, J. Li, H. J. Hyun, Y. Miyazaki, I. Tikhomirov, A. Chen, U. Bitenc, S. Eidelman, H. Park, A. Bozek, X. L. Wang, Joowon Lee, T. E. Browder, and A. Zupanc

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, Muon, Meson, Branching fraction, Electron–positron annihilation, Electron, law.invention, Nuclear physics, KEKB, law, Collider, Lepton
Abstract

We search for lepton-flavor-violating τ decays into a lepton (electron or muon) and an f0 (980) meson using 671 fb-1 of data collected with the Belle detector at the KEKB asymmetric-energy e+ e- collider. No events are observed and we set the following 90% C.L. upper limits on the branching fraction products: B (τ- → e- f0 (980)) × B (f0 (980) → π+ π-) < 3.2 × 10- 8 and B (τ- → μ- f0 (980)) × B (f0 (980) → π+ π-) < 3.4 × 10- 8. This is the first search performed for these modes. © 2009 Elsevier B.V.

Published
2009
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21. Study of Ωc0 and Ωc∗0 baryons at Belle

Author

Y. Iwasaki, Y. J. Kwon, Joowon Lee, O. Schneider, T. E. Browder, H. J. Hyun, M. Danilov, L. S. Peak, Vladimir Zhulanov, Y. Miyazaki, M. E. Sevior, A. Zupanc, M. Starič, J. H. Kang, M. Yamauchi, O. Nitoh, S. Eidelman, Vladislav Balagura, P. Pakhlov, D. Liventsev, H. K. Park, J. G. Shiu, Y. Sakai, K. Inami, G. S. Varner, A. Kuzmin, Y. Yamashita, E. Solovieva, Phillip Urquijo, W. S. Hou, H. Kichimi, R. Itoh, K. Arinstein, P. Chang, S. Ogawa, T. Lesiak, P. Wang, Yu. V. Usov, S. Nishida, M. Tanaka, P. Krokovny, O. Zyukova, Masashi Hazumi, X. L. Wang, K. Miyabayashi, S. H. Kyeong, A. Ishikawa, S. K. Choi, S. E. Lee, P. Križan, Y. I. Kim, S. Okuno, M. J. Lee, K. Kinoshita, H. Sahoo, E. Won, B. G. Cheon, M. Bračko, D. Heffernan, T. Uglov, T. Aushev, I. S. Cho, G. N. Taylor, Hirokazu Ishino, Y. Teramoto, Bruce Yabsley, A. M. Bakich, T. Ohshima, K. Senyo, M. Dash, C. H. Wang, U. Bitenc, H. Kawai, A. Bondar, T. Kawasaki, Y. Choi, J. S. Lange, J. Dalseno, I. Tikhomirov, S. Korpar, Jolanta Brodzicka, A. Chen, Yasushi Nagasaka, Samo Stanič, M. Shapkin, Y. J. Kim, Rakesh Kumar, H. Palka, L. E. Piilonen, G. Pakhlova, R. Chistov, T. Sumiyoshi, S. Noguchi, S. Uehara, H. Ha, N. Katayama, R. Mizuk, Y. Unno, I. Adachi, H. Miyata, Y. Hoshi, K. Hayasaka, D. H. Kah, T. Zivko, Y. B. Hsiung, Z. P. Zhang, H. O. Kim, A. Matyja, H. Aihara, C. Liu, M. Nakao, Y. Watanabe, S. McOnie, H. J. Kim, Motoki Iwasaki, S. Uno, and C. Schwanda

Subjects
Nuclear physics, Baryon, Physics, Nuclear and High Energy Physics, Particle physics, KEKB, 010308 nuclear & particles physics, law, 0103 physical sciences, 010306 general physics, Collider, 01 natural sciences, law.invention
Abstract

We report results from a study of the charmed double strange baryons Ωc 0 and Ωc * 0 at Belle. The Ωc 0 is reconstructed using the Ωc 0 → Ω- π+ decay mode, and its mass is measured to be (2693.6 ± 0.3-1.5 +1.8) MeV / c2. The Ωc * 0 baryon is reconstructed in the Ωc 0 γ mode. The mass difference MΩc* 0 - MΩc0 is measured to be (70.7 ± 0.9-0.9 +0.1) MeV / c2. The analysis is performed using 673 fb-1 of data on and near the Υ{hooked} (4 S) collected with the Belle detector at the KEKB asymmetric-energy e+ e- collider. © 2008 Elsevier B.V. All rights reserved.

Published
2009
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22. Search for a CP asymmetry in Cabibbo-suppressed D0 decays

Author

Y. Sakai, H. Miyata, J. G. Shiu, H. Kichimi, Y. Hoshi, T. Tsuboyama, T. Lesiak, J. Schümann, K. Hayasaka, Phillip Urquijo, H. Palka, M. Tanaka, L. E. Piilonen, G. Pakhlova, K. F. Chen, A. Zupanc, D. Heffernan, D. Liventsev, F. Mandl, S. Uehara, M. E. Sevior, H. Ha, O. Nitoh, G. S. Varner, M. Shapkin, Andrey Sokolov, R. Chistov, Masashi Hazumi, Hiroaki Aihara, R. Itoh, D. H. Kah, I. Adachi, C. Z. Yuan, Y. J. Kim, P. Wang, Yu. V. Usov, H. Sahoo, T. Uglov, Yoji Hasegawa, Antonio Limosani, C. C. Zhang, Y. Chao, O. Zyukova, M. Iwasaki, T. Zivko, Zhenyu Zhang, H. Ozaki, K. Vervink, Rakesh Kumar, H. K. Park, Y. Yamashita, Yoshinobu Unno, M. Nakao, S. McOnie, E. Nakano, S. H. Kyeong, T. Sumiyoshi, Jeremy Dalseno, S. K. Kim, G. R. Moloney, H. Kaji, S. Fratina, Hirokazu Ishino, I. S. Cho, P. Chang, J. Haba, H. O. Kim, E. L. Barberio, R. Pestotnik, K. Trabelsi, L. S. Peak, Jasvinder A. Singh, Yu-xi Liu, P. Krokovny, Yasushi Nagasaka, S. Okuno, Y. Choi, W. Dungel, C. H. Wang, A. Bondar, K. Belous, S. Korpar, Jolanta Brodzicka, S. Uno, C. Schwanda, T. Aushev, Y. Watanabe, Y. Teramoto, Bruce Yabsley, A. Ishikawa, A. Bay, T. Hara, S. E. Lee, T. Nozaki, A. Matyja, F. Takasaki, C. W. Park, A. Somov, B. Shwartz, P. Križan, T. Mori, I. Bedny, A.S. Kuzmin, M. Starič, B. G. Cheon, A. Chen, U. Bitenc, Y. J. Kwon, H. J. Hyun, O. Schneider, Y. Miyazaki, T. E. Browder, S. Eidelman, P. Pakhlov, H. Park, A. Bozek, A. Sekiya, S. Nishida, X. L. Wang, Y. I. Kim, K. Kinoshita, G. N. Taylor, Anton Poluektov, H. Hayashii, K. Inami, A. M. Bakich, Z. Natkaniec, T. Ohshima, N. Gabyshev, Samo Stanič, K. Senyo, T. Kawasaki, M. J. Lee, M. Bračko, H. Nakazawa, W. S. Hou, A. J. Schwartz, H. J. Kim, K. Arinstein, Chang Liu, M. Dash, B. Golob, V. Bhardwaj, J. S. Lange, V.N. Zhilich, E. Won, Tadashi Nagamine, and K. Miyabayashi

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, 010308 nuclear & particles physics, Electron–positron annihilation, media_common.quotation_subject, Detector, Measure (physics), 01 natural sciences, Resonance (particle physics), Asymmetry, Nuclear physics, 0103 physical sciences, CP violation, 010306 general physics, media_common
Abstract

We measure the CP-violating asymmetries in decays to the D0 → K+ K- and D0 → π+ π- CP eigenstates using 540 fb-1 of data collected with the Belle detector at or near the Υ{hooked} (4 S) resonance. Cabibbo-favored D0 → K- π+ decays are used to correct for systematic detector effects. The results, ACP K K = (- 0.43 ± 0.30 ± 0.11) % and ACP π π = (+ 0.43 ± 0.52 ± 0.12) %, are consistent with no CP violation. © 2008 Elsevier B.V. All rights reserved.

Published
2008
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23. Study of intermediate two-body decays in B¯0→Σc(2455)0p¯π+

Author

A. Ishikawa, C. W. Park, P. Križan, J. H. Kang, Joowon Lee, A. M. Bakich, Z. Natkaniec, T. Ohshima, D. Liventsev, T. Iijima, J. G. Shiu, H. Nakazawa, T. E. Browder, Y. Watanabe, A. Zupanc, J. B. Singh, G. S. Varner, A. Somov, N. Gabyshev, O. Nitoh, M. Tanaka, I. Bedny, Phillip Urquijo, B. Shwartz, R. Itoh, K. Inami, U. Bitenc, D. H. Kah, E. Won, P. Chang, S. W. Lin, M. Nakao, P. Wang, Yu. V. Usov, S. Eidelman, T. Zivko, S. McOnie, M. Z. Wang, Y. Unno, H. J. Kim, D. Heffernan, O. Zyukova, Rakesh Kumar, H. Miyata, A. Kuzmin, I. S. Cho, Y. Hoshi, H. J. Hyun, V.N. Zhilich, G. N. Taylor, D. Epifanov, S. Ogawa, S. Uehara, H. Ha, K. Hayasaka, H. Park, A. Bozek, L. E. Piilonen, N. Katayama, B. G. Cheon, Y. Miyazaki, M. Dash, Masashi Hazumi, Anton Poluektov, S. Okuno, K. S. Park, I. Adachi, V. M. Aulchenko, A. Matyja, C. H. Wang, Vladimir Zhulanov, S. Nishida, H. K. Park, Y. Yamashita, S. Uno, H. Sahoo, Vladislav Balagura, M. E. Sevior, T. Aushev, M. Shapkin, K. Senyo, K. Miyabayashi, X. L. Wang, H. Aihara, V.E. Shebalin, R. Chistov, Samo Stanič, T. Kawasaki, Y. J. Kim, Y. I. Kim, Y. Teramoto, A. Bondar, S. Korpar, T. Sumiyoshi, W. S. Hou, Y. Chao, A. Vinokurova, K. Arinstein, R. Pestotnik, M. Yamauchi, P. Krokovny, H. Kichimi, Z. P. Zhang, Y. Sakai, T. Lesiak, Y. Choi, H. O. Kim, M. J. Lee, J. Dalseno, M. Bračko, Motoki Iwasaki, L. S. Peak, M. Starič, Y. Iwasaki, Y. J. Kwon, O. Schneider, and H. Kawai

Subjects
Physics, Nuclear and High Energy Physics, 010308 nuclear & particles physics, Electron–positron annihilation, Analytical chemistry, Resonance, 01 natural sciences, Baryon, Nuclear physics, KEKB, 0103 physical sciences, B meson, Invariant mass, 010306 general physics
Abstract

We present results of a detailed study of the three-body over(B, )0 → Σc (2455)0 over(p, ) π+ decay. A significant enhancement of signal events is observed in the over(p, ) π+ invariant mass distribution near 1.5 GeV / c2 that is consistent with the presence of an intermediate baryonic resonance over(N, )0, where over(N, )0 is the over(N, ) (1440)0 P11 or over(N, ) (1535)0 S11 state, or an admixture of the two states. We measure the product B (over(B, )0 → Σc (2455)0 over(N, )0) × B (over(N, )0 → over(p, ) π+) = (0.80 ± 0.15 (stat .) ± 0.14 (syst .) ± 0.21) × 10-4, where the last error is due to the uncertainty in B (Λc + → p K- π+). The significance of the signal is 6.1 standard deviations. This analysis is based on a data sample of 357 fb-1, accumulated at the Υ{hooked} (4 S) resonance with the Belle detector at the KEKB asymmetric-energy e+ e- collider. © 2008 Elsevier B.V.

Published
2008
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24. New search for τ→μγ and τ→eγ decays at Belle

Author

S. K. Kim, I. Bizjak, H. Miyake, F. Mandl, S. E. Lee, T. Gershon, S. L. Olsen, Z. P. Zhang, K. Hayasaka, O. Nitoh, K. Miyabayashi, J. Brodzicka, A. Chen, H. Hayashii, R. Chistov, T. Lesiak, R. Itoh, T. Matsumoto, C. C. Kuo, S. W. Lin, N. Gabyshev, H. Miyata, P. Krokovny, X. C. Tian, K. Abe, Y. Kozakai, A. Sokolov, Y. Yamashita, C. C. Wang, W. S. Hou, T. Sumiyoshi, A. Kuzmin, L. S. Peak, P. Pakhlov, H. Aihara, D. Liventsev, H. Stoeck, M. E. Sevior, A. Imoto, Y. Teramoto, H. Sahoo, Y. Iwasaki, S. Okuno, N. Soni, I. Tikhomirov, Y. Usov, K. Senyo, G. R. Moloney, A. Bay, T. Schietinger, A.J. Schwartz, J. Haba, J. B. Singh, B. G. Cheon, O. Schneider, Q. L. Xie, S. Hou, S. Stanič, Y. Miyazaki, H. Nakazawa, B. Golob, N. Satoyama, J. H. Kang, H. Ha, A. Ishikawa, K. Arinstein, D. Heffernan, M. Yamauchi, S. Villa, W. T. Chen, T. Hokuue, T. Mori, G. N. Taylor, Y. Chao, K. S. Park, S. Eidelman, M. Nakao, Y. Nagasaka, A. Poluektov, T. Tsukamoto, J. Dalseno, H. Ozaki, E. Barberio, T. Hara, K. Inami, Y. Watanabe, T. Kawasaki, H.K Park, A. Bozek, S. Nishida, K. Tamai, S. Fratina, N. Tamura, M. Hazumi, Z. Natkaniec, P. Križan, A. Go, V. Aulchenko, D. Anipko, K. Belous, A. Yamaguchi, Y. Onuki, S. Uno, Hiroyuki Kaji, M. Starič, T. Uglov, K. Ueno, Y. K. Choi, Y. Sakai, V. Zhulanov, M. Shapkin, R. Kulasiri, H. R. Khan, A. Zupanc, Y. J. Kim, U. Bitenc, L. E. Piilonen, P. Chang, I. Adachi, S. Ogawa, A. Bondar, Masayuki Tanaka, M. C. Chang, Y. Hoshi, A. Drutskoy, Y. J. Kwon, M. Iwasaki, B. D. Yabsley, Y. Choi, C. H. Wang, I. Bedny, S. Uehara, H. Kichimi, F. Takasaki, V. Zhilich, A. Vinokurova, M. Danilov, P. Urquijo, A. Somov, R. Seidl, T. Tsuboyama, D. Epifanov, M. Dash, R. Kumar, T. Iijima, A. M. Bakich, T. Ohshima, G. Varner, K. Ikado, H. Shibuya, B. Shwartz, Kazuhiko Hara, H. Kawai, Michael J. Lee, E. Won, R. Pestotnik, G. Pakhlova, and M. Bračko

Subjects
Nuclear physics, Physics, Nuclear and High Energy Physics, Particle physics, KEKB, Electron–positron annihilation, Lepton number, Belle experiment, Lepton
Abstract

We report on a search for the lepton flavor violating τ−→μ−γ and τ−→e−γ decays based on 535 fb−1 of data accumulated at the Belle experiment. No signal is found and we set 90% confidence level upper limits on the branching ratios B(τ−→μ−γ)

Published
2008
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25. Measurement of masses of the Ξc(2645) and Ξc(2815) baryons and observation of Ξc(2980)→Ξc(2645)π

Author

T. Lesiak, I. Adachi, H. Aihara, K. Arinstein, A.M. Bakich, V. Balagura, E. Barberio, I. Bedny, K. Belous, V. Bhardwaj, U. Bitenc, S. Blyth, A. Bozek, M. Bračko, J. Brodzicka, T.E. Browder, Y. Chao, A. Chen, W.T. Chen, B.G. Cheon, R. Chistov, I.-S. Cho, S.-K. Choi, Y. Choi, J. Dalseno, M. Dash, S. Eidelman, N. Gabyshev, B. Golob, H. Ha, J. Haba, K. Hayasaka, M. Hazumi, D. Heffernan, Y. Hoshi, W.-S. Hou, H.J. Hyun, K. Inami, A. Ishikawa, H. Ishino, R. Itoh, M. Iwasaki, Y. Iwasaki, N.J. Joshi, D.H. Kah, H. Kaji, J.H. Kang, H. Kawai, T. Kawasaki, H. Kichimi, H.J. Kim, S.K. Kim, Y.J. Kim, S. Korpar, P. Križan, P. Krokovny, C.C. Kuo, Y.-J. Kwon, S. Lange, J.S. Lee, M.J. Lee, S.E. Lee, J. Li, S.-W. Lin, C. Liu, D. Liventsev, F. Mandl, S. McOnie, T. Medvedeva, K. Miyabayashi, H. Miyake, H. Miyata, Y. Miyazaki, R. Mizuk, G.R. Moloney, Y. Nagasaka, M. Nakao, Z. Natkaniec, S. Nishida, O. Nitoh, T. Nozaki, S. Ogawa, T. Ohshima, S. Okuno, H. Ozaki, G. Pakhlova, H. Palka, C.W. Park, H.K. Park, L.S. Peak, R. Pestotnik, L.E. Piilonen, H. Sahoo, Y. Sakai, O. Schneider, K. Senyo, M.E. Sevior, M. Shapkin, H. Shibuya, J.-G. Shiu, B. Shwartz, A. Sokolov, S. Stanič, M. Starič, T. Sumiyoshi, F. Takasaki, M. Tanaka, G.N. Taylor, Y. Teramoto, I. Tikhomirov, K. Trabelsi, T. Tsuboyama, S. Uehara, K. Ueno, T. Uglov, Y. Unno, S. Uno, P. Urquijo, G. Varner, K.E. Varvell, K. Vervink, C.C. Wang, C.H. Wang, M.-Z. Wang, P. Wang, X.L. Wang, Y. Watanabe, R. Wedd, E. Won, B.D. Yabsley, H. Yamamoto, Y. Yamashita, M. Yamauchi, Z.P. Zhang, V. Zhilich, V. Zhulanov, A. Zupanc, and O. Zyukova

Subjects
Physics, Baryon, Nuclear and High Energy Physics, Particle physics, KEKB, 010308 nuclear & particles physics, 0103 physical sciences, Pi, 010306 general physics, 01 natural sciences
Abstract

We report a precise measurement of the masses of the $\Xi_c(2645)$ and $\Xi_c(2815)$ baryons using a data sample of 414 fb$^{-1}$ collected by the Belle collaboration at the KEKB $e^+ e^-$ collider. The states $\Xi_c(2645)^{0,+}$ are observed in the $\Xi_c^{+,0}\pi^{-,+}$ decay modes, while the $\Xi_c(2815)^{0,+}$ are reconstructed in the $\Xi_c(2645)^{+,0}\pi^{-,+}$ decay modes. The following mass splittings are determined: $m_{\Xi_c(2645)^+} - m_{\Xi_c(2645)^0} = (-0.1 \pm 0.3 ({\rm stat}) \pm 0.6 {(\rm syst})) {\rm MeV}/{\rm c}^2$ and $m_{\Xi_c(2815)^+} - m_{\Xi_c(2815)^0} = (-3.4 \pm 1.9 ({\rm stat}) \pm 0.9 {(\rm syst})) {\rm MeV}/{\rm c}^2$ with a much better precision than the current world averages. We also observe a new decay mode, $\Xi_c(2980)^{0,+} \to \Xi_c(2645)^{+,0}\pi^{-,+}$.

Published
2008
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26. Study of the decay mechanism for B+→pp¯K+ and B+→pp¯π+

Author

S. Okuno, T. Iijima, L. E. Piilonen, T. Aushev, V. M. Aulchenko, G. Pakhlova, E. L. Barberio, M. Z. Wang, K. Kinoshita, Y. Teramoto, G. N. Taylor, S. Nishida, I. Tikhomirov, A. Chen, Samo Stanič, Y. Iwasaki, M. Shapkin, Robin Wedd, Y. J. Kim, H. Ozaki, Y. J. Kwon, M. Yamauchi, A. M. Bakich, T. Ohshima, E. Nakano, O. Schneider, H. J. Hyun, A. Kuzmin, C. C. Chiang, P. Chang, K. Senyo, M. Nakao, K. Ueno, Joowon Lee, Y. Unno, Andrey Sokolov, T. Kawasaki, V.N. Zhilich, C. C. Zhang, A. Yamaguchi, N. Gabyshev, H. Hayashii, S. W. Lin, R. Pestotnik, S. McOnie, T. E. Browder, S. Ogawa, H. Shibuya, H. Miyake, W. A. Mitaroff, J. H. Kang, A. Somov, R. Seidl, Y. Miyazaki, K. F. Chen, Young-Il Choi, D. Liventsev, K. Miyabayashi, S. Uehara, M. Danilov, C. C. Kuo, S. Uno, Y. Chao, I. S. Cho, G. S. Varner, T. Hokuue, S. Eidelman, P. Pakhlov, R. Mizuk, H. Ha, A. Ishikawa, A. Bay, N. Katayama, R. Itoh, S. E. Lee, S. Fratina, F. Takasaki, M. Starič, Rakesh Kumar, P. Wang, C. W. Park, P. Križan, K. Inami, H. Park, A. Bozek, F. Mandl, I. Adachi, Y. Sakai, Z. P. Zhang, C. H. Wang, U. Bitenc, Y. Yamashita, K. Tamai, S. Villa, K. Ikado, Masashi Hazumi, T. Matsumoto, T. Sumiyoshi, M. Bračko, Yu-xi Liu, H. Sahoo, M. E. Sevior, T. Uglov, Kevin Varvell, Osamu Tajima, A. Matyja, A. Zupanc, O. Nitoh, H. Aihara, Y. Choi, T. Hara, M. Tanaka, X. C. Tian, B. G. Cheon, J. Haba, A. Bondar, K. Belous, S. Korpar, D. Heffernan, E. Won, J. G. Shiu, Phillip Urquijo, M. Dash, B. Golob, S. Cole, H. Kichimi, T. Tsuboyama, T. Lesiak, K. Vervink, H. Kawai, Y. Watanabe, A. Vinokurova, Motoki Iwasaki, P. Krokovny, Yasushi Nagasaka, K. S. Park, Vladislav Balagura, S. L. Olsen, H. Miyata, Y. Hoshi, Tatiana Medvedeva, J. Schümann, K. Hayasaka, J. T. Wei, D. H. Kah, Y. B. Hsiung, J. B. Singh, A. Drutskoy, and C. C. Wang

Subjects
Physics, Nuclear and High Energy Physics, Near threshold, KEKB, Electron–positron annihilation, Analytical chemistry, Pi, High Energy Physics::Experiment, Atomic physics, Helicity
Abstract

We study the characteristics of the low mass p (p) over bar enhancements near threshold in the three-body decays B+ -> p (p) over barK(+) and B+ -> p (p) over bar pi(+). We observe that the proton polar angle distributions in the p (p) over bar helicity frame in the two decays have the opposite polarity, and measure the forward-backward asymmetries as a function of the p mass for the p (p) over barK(+) mode. We also search for the intermediate two-body decays, B+ -> (p) over bar Delta(++) and B+ -> p (Delta) over bar (0), and set upper limits on their branching fractions. These results are obtained from a 414 fb(-1) data sample that contains 449 x 10(6) B (B) over bar events collected near the Gamma(4S) resonance with the Belle detector at the KEKB asymmetric-energy e(+)e(-) collider. (c) 2007 Elsevier B.V. All rights reserved.

Published
2008
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27. Status and upgrade plans of the Belle silicon vertex detector

Author

Masashi Hazumi, L. S. Peak, Christian Irmler, G. R. Moloney, N. Tamura, M. Rosen, Daniel Robert Marlow, Marco Barbero, K. Trabelsi, M. C. Chang, K. Uchida, Hitoshi Yamamoto, T. Ziegler, Kevin Varvell, Y. Nakahama, Y. Choi, T. Higuchi, N. K. Joshi, M. Z. Wang, A. Kibayashi, S. Kajiwara, T. Kameshima, N. Tani, S. Fratina, G. N. Taylor, C. C. Wang, M. Pernicka, Y. Ushiroda, S. Koike, M. Rozanska, K. Hara, Akito Kusaka, A. Das, H. Miyake, Samo Stanič, Takeo Kawasaki, T. Hirakawa, A. M. Bakich, Z. Natkaniec, H. Steininger, Osamu Tajima, Y. Fujiyama, T. E. Browder, K. Sumisawa, S. Ono, Markus Friedl, A. Chouvikov, S. Chidzik, Samo Korpar, S. Schmid, J. Schümann, M. H. Tanaka, Y. Velikzhanin, Y. J. Kim, Hiroaki Aihara, H. Ozaki, T. Takahashi, M. Watanabe, Y. Yamashita, Nobuaki Sato, Y. Chao, T. Hara, Y. Asano, S. Okuno, Hirokazu Ishino, H. Kurashiro, P. Križan, G. S. Varner, Tsukasa Aso, T. Arakawa, H. Kakuno, Kai-Feng Chen, Kenji Hayashi, B. Harrop, J. Dalseno, J. Haba, D. Heffernan, K. Ueno, Y. Watanabe, T. Tsuboyama, and W. Ostrowicz

Subjects
Physics, Nuclear and High Energy Physics, Physics::Instrumentation and Detectors, business.industry, Detector, Electrical engineering, Silicon vertex detector, Third generation, Nuclear physics, Upgrade, KEKB, High Energy Physics::Experiment, business, Instrumentation, Degradation (telecommunications)
Abstract

The second generation of Belle Silicon Vertex Detector (SVD) has been efficiently operated for more than three years. With increasing beam-induced background, a degradation of the detector performance is expected. To avoid such a difficulty, we are planing a next upgrade, the third generation of the SVD. Currently, its design is almost finalized.

Published
2007
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28. A study of γγ→KS0KS0 production at energies from 2.4 to 4.0 GeV at Belle

Author

W.T. Chen, K. Abe, I. Adachi, H. Aihara, D. Anipko, V. Aulchenko, A.M. Bakich, E. Barberio, A. Bay, I. Bedny, U. Bitenc, I. Bizjak, S. Blyth, A. Bondar, A. Bozek, M. Bračko, T.E. Browder, M.-C. Chang, P. Chang, Y. Chao, A. Chen, B.G. Cheon, R. Chistov, Y. Choi, Y.K. Choi, J. Dalseno, M. Dash, A. Drutskoy, S. Eidelman, D. Epifanov, A. Go, H. Ha, M. Hazumi, D. Heffernan, T. Higuchi, T. Hokuue, Y. Hoshi, W.-S. Hou, T. Iijima, A. Imoto, K. Inami, A. Ishikawa, R. Itoh, M. Iwasaki, H. Kaji, J.H. Kang, P. Kapusta, N. Katayama, H. Kawai, T. Kawasaki, H. Kichimi, H.O. Kim, Y.J. Kim, S. Korpar, P. Križan, P. Krokovny, R. Kulasiri, R. Kumar, C.C. Kuo, A. Kuzmin, Y.-J. Kwon, S.E. Lee, T. Lesiak, S.-W. Lin, D. Liventsev, G. Majumder, F. Mandl, T. Matsumoto, A. Matyja, S. McOnie, T. Medvedeva, H. Miyata, Y. Miyazaki, R. Mizuk, G.R. Moloney, T. Mori, E. Nakano, M. Nakao, H. Nakazawa, Z. Natkaniec, S. Nishida, O. Nitoh, T. Nozaki, S. Ogawa, T. Ohshima, S. Okuno, S.L. Olsen, Y. Onuki, H. Ozaki, P. Pakhlov, G. Pakhlova, H. Palka, C.W. Park, R. Pestotnik, L.E. Piilonen, H. Sahoo, Y. Sakai, N. Satoyama, T. Schietinger, O. Schneider, J. Schümann, K. Senyo, M.E. Sevior, M. Shapkin, H. Shibuya, B. Shwartz, J.B. Singh, A. Sokolov, A. Somov, N. Soni, S. Stanič, M. Starič, H. Stoeck, S.Y. Suzuki, F. Takasaki, K. Tamai, M. Tanaka, G.N. Taylor, Y. Teramoto, X.C. Tian, I. Tikhomirov, T. Tsukamoto, S. Uehara, K. Ueno, T. Uglov, Y. Unno, S. Uno, Y. Usov, G. Varner, K. Vervink, S. Villa, C.C. Wang, C.H. Wang, M.-Z. Wang, Y. Watanabe, E. Won, B.D. Yabsley, A. Yamaguchi, Y. Yamashita, M. Yamauchi, C.C. Zhang, Z.P. Zhang, V. Zhilich, and A. Zupanc

Subjects
Quantum chromodynamics, Physics, Nuclear and High Energy Physics, Particle physics, Angular range, Range (particle radiation), Meson, law.invention, Nuclear physics, KEKB, law, Center of mass, Collider, Positron annihilation
Abstract

KS 0 KS 0 production in two-photon collisions has been studied using a 397.6 fb-1 data sample collected with the Belle detector at the KEKB e+ e- collider. For the first time the cross sections are measured in the two-photon center-of-mass energy range between 2.4 GeV and 4.0 GeV and angular range | cos θ* | < 0.6. Combining the results with measurements of γ γ → K+ K- from Belle, we observe that the cross section ratio σ (KS 0 KS 0) / σ (K+ K-) decreases from ∼0.13 to ∼0.01 with increasing energy. Signals for the χc 0 and χc 2 charmonium states are also observed. © 2007 Elsevier B.V. All rights reserved.

Published
2007
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29. Search for lepton flavor violating τ− decays into ℓ−η, ℓ−η′ and ℓ−π0

Author

Y. Miyazaki, I. Adachi, H. Aihara, D. Anipko, K. Arinstein, V. Aulchenko, T. Aziz, A.M. Bakich, E. Barberio, A. Bay, I. Bedny, K. Belous, U. Bitenc, I. Bizjak, A. Bondar, M. Bračko, T.E. Browder, A. Chen, W.T. Chen, B.G. Cheon, Y. Choi, Y.K. Choi, J. Dalseno, S. Eidelman, D. Epifanov, S. Fratina, N. Gabyshev, A. Go, A. Gorišek, H. Ha, J. Haba, K. Hayasaka, H. Hayashii, M. Hazumi, D. Heffernan, T. Hokuue, Y. Hoshi, S. Hou, W.-S. Hou, T. Iijima, A. Imoto, K. Inami, A. Ishikawa, R. Itoh, M. Iwasaki, Y. Iwasaki, H. Kaji, P. Kapusta, H. Kawai, T. Kawasaki, H. Kichimi, Y.J. Kim, S. Korpar, P. Križan, P. Krokovny, R. Kulasiri, R. Kumar, C.C. Kuo, A. Kuzmin, Y.-J. Kwon, M.J. Lee, T. Lesiak, S.-W. Lin, F. Mandl, T. Matsumoto, H. Miyake, H. Miyata, T. Nagamine, Y. Nagasaka, M. Nakao, S. Nishida, O. Nitoh, S. Ogawa, T. Ohshima, S. Okuno, Y. Onuki, H. Ozaki, P. Pakhlov, G. Pakhlova, H. Park, L.S. Peak, R. Pestotnik, L.E. Piilonen, A. Poluektov, H. Sahoo, Y. Sakai, N. Satoyama, T. Schietinger, O. Schneider, J. Schümann, C. Schwanda, A.J. Schwartz, K. Senyo, M.E. Sevior, H. Shibuya, B. Shwartz, V. Sidorov, J.B. Singh, A. Somov, N. Soni, S. Stanič, M. Starič, H. Stoeck, T. Sumiyoshi, F. Takasaki, K. Tamai, M. Tanaka, G.N. Taylor, Y. Teramoto, X.C. Tian, I. Tikhomirov, T. Tsukamoto, S. Uehara, K. Ueno, Y. Unno, S. Uno, P. Urquijo, Y. Usov, G. Varner, S. Villa, A. Vinokurova, C.H. Wang, M. Watanabe, Y. Watanabe, E. Won, A. Yamaguchi, Y. Yamashita, M. Yamauchi, Z.P. Zhang, V. Zhilich, V. Zhulanov, and A. Zupanc

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, KEKB, Pi, High Energy Physics::Experiment, Pseudoscalar meson, Lepton
Abstract

We have searched for lepton-flavor-violating $\tau$ decays with a pseudoscalar meson ($\eta$, $\eta'$ {and} $\pi^0$) using a data sample of 401 fb$^{-1}$ collected with the Belle detector at the KEKB asymmetric-energy $e^+e^-$ collider. No evidence for these decays is found and we set the following upper limits on the branching fractions: ${\cal{B}}(\tau^-\to e^-\eta) < 9.2\times 10^{-8}$, ${\cal{B}}(\tau^-\to \mu^-\eta) < 6.5\times 10^{-8}$, ${\cal{B}}(\tau^-\to e^-\eta') < 1.6\times 10^{-7}$, ${\cal{B}}(\tau^-\to \mu^-\eta') < 1.3\times 10^{-7}$, ${\cal{B}}(\tau^-\to e^-\pi^0) < 8.0\times 10^{-8}$ and ${\cal{B}}(\tau^-\to \mu^-\pi^0) < 1.2\times 10^{-7}$ at the 90% confidence level. These results improve our previously published upper limits by factors from 2.3 to 6.3.

Published
2007
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30. A search for the rare leptonic decays B+→μ+νμ and B+→e+νe

Author

Andrey Sokolov, Y. Iwasaki, G. Leder, P. Krokovny, Y. J. Kwon, Y. Onuki, N. Tamura, J. H. Kang, O. Schneider, A. Zupanc, K. Tamai, K. Sumisawa, H. Stoeck, M. H. Tanaka, O. Nitoh, C. H. Wang, R. Seidl, Samo Stanič, K. Ikado, M. E. Sevior, S. U. Kataoka, S. Nishida, N. Soni, W. T. Chen, E. L. Barberio, D. Anipko, P. Chang, Phillip Urquijo, Hiroaki Aihara, Y. Yamashita, I. Bedny, I. Nakamura, H. Sahoo, J. Dalseno, M. C. Chang, Q. L. Xie, T. Uglov, Yoji Hasegawa, Y. Choi, E. Nakano, M. Starič, Zhenyu Zhang, T. Nagamine, Rakesh Kumar, Y. Sakai, A. Drutskoy, T. Mori, H. Miyake, H. R. Khan, A. Somov, N. Satoyama, A.S. Kuzmin, U. Bitenc, M. J. Lee, P. Pakhlov, Y. Watanabe, S. Uno, C. Schwanda, M. Bračko, H. Kichimi, S. K. Kim, T. Iijima, H. Miyata, H. Nakazawa, G. Gokhroo, S. R. Hou, S. Fratina, H. J. Kim, Kazuo Abe, T. Tsuboyama, S. Cole, Y. Hoshi, T. Lesiak, S. Okuno, A. Yamaguchi, Gobinda Majumder, E. Won, T. J. Gershon, S. Noguchi, Jasvinder A. Singh, S. W. Lin, H. Park, A. Bozek, T. Tsukamoto, A. M. Bakich, S. Ogawa, M. Z. Wang, K. Kinoshita, T. Sumiyoshi, T. Matsumoto, Z. Natkaniec, T. Ohshima, H. Shibuya, M. Iwasaki, V.N. Zhilich, Y. Miyazaki, K. Hayasaka, Y. Teramoto, Bruce Yabsley, J. Schümann, B. Shwartz, S. Eidelman, N. Gabyshev, T. Hokuue, M. Yamauchi, G. N. Taylor, J. S. Lange, L. E. Piilonen, T. Schietinger, Young-Il Choi, G. Pakhlova, X. C. Tian, T. E. Browder, A. Go, D. Heffernan, S. Uehara, J. Haba, C. C. Kuo, W. S. Hou, H. Ha, N. Katayama, H. Kawai, R. Chistov, A. Bondar, K. Inami, K. Belous, S. Korpar, Byung Gu Cheon, R. Mizuk, M. Nakao, I. Adachi, S. McOnie, M. Dash, C. C. Wang, S. Villa, K. Senyo, T. Kawasaki, D. Liventsev, I. Bizjak, G. S. Varner, R. Itoh, S. Suzuki, A. Ishikawa, T. Nozaki, F. Takasaki, P. Križan, Antonio Limosani, I. Tikhomirov, A. Chen, M. Shapkin, Robin Wedd, Y. J. Kim, H. Ozaki, and R. Pestotnik

Subjects
Charmed baryons, Physics, Nuclear and High Energy Physics, Particle physics, Web of science, Electron–positron annihilation
Abstract

Reference EPFL-ARTICLE-154485doi:10.1016/j.physletb.2007.01.068View record in Web of Science Record created on 2010-11-05, modified on 2017-05-12

Published
2007
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31. Silicon vertex detector for the KEK Super B factory

Author

P. Križan, A. Kibayashi, Kevin Varvell, Y. Nakahama, K. Ueno, Y. Fujiyama, T. Ziegler, G. R. Moloney, Y. Watanabe, T. Arakawa, A. Chouvikov, M. H. Tanaka, L. S. Peak, Kenji Hayashi, H. Kakuno, Kai-Feng Chen, Markus Friedl, Y. Yamashita, Samo Korpar, T. Hirakawa, M. Rozanska, N. Tani, K. Sumisawa, Y. Chao, Nobuaki Sato, T. Takahashi, B. Harrop, Akito Kusaka, Masashi Hazumi, Hirokazu Ishino, Y. J. Kim, J. Dalseno, Osamu Tajima, H. Ozaki, W. Ostrowicz, A. M. Bakich, Z. Natkaniec, S. Chidzik, H. Steininger, M. Rosen, T. Kawasaki, Marco Barbero, T. Tsuboyama, N. Tamura, M. C. Chang, S. Fratina, T. Hara, M. Z. Wang, H. Kurashiro, Y. Ushiroda, Y. Asano, S. Ono, N. K. Joshi, S. Okuno, S. Kajiwara, G. N. Taylor, J. Haba, M. Watanabe, Hiroaki Aihara, D. Heffernan, K. Trabelsi, S. Koike, S. Schmid, H. Miyake, T. Higuchi, Daniel Robert Marlow, Samo Stanič, Christian Irmler, Y. Velikzhanin, K. Uchida, Hitoshi Yamamoto, Y. Choi, T. Kameshima, T. E. Browder, A. Das, K. Hara, G. S. Varner, Tsukasa Aso, J. Schümann, C. C. Wang, and M. Pernicka

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, Luminosity (scattering theory), High data rate, Instrumentation, Silicon vertex detector, B-factory
Abstract

In order to extend the physics reach of the present B factories, a letter of intent for a Super B factory, with a luminosity of 4×1035cm-2s-1, was submitted in 2004. The paper summarizes recent progress in the design and technological solutions for the silicon vertex detector to be operated at the expected high data rate and background condition of a Super B factory.

Published
2007
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32. Belle silicon vertex detector for the Super B Factory

Author

Osamu Tajima, S. Fratina, W. Ostrowicz, Y.S. Velikzhanin, T. Ziegler, N. Tamura, S. Chidzik, Hiroaki Aihara, Christian Irmler, M. Z. Wang, K. Ueno, Y. Fujiyama, A. Chouvikov, S. Kajiwara, Kazumasa Takahashi, G. N. Taylor, M. Rozanska, Akito Kusaka, Markus Friedl, G. R. Moloney, K. Trabelsi, T. Tsuboyama, Hirokazu Ishino, N. Tani, T. Hirakawa, L. S. Peak, Y. Onuki, H. Ozaki, K. Sumisawa, H. Kurashiro, J. Haba, H. Kakuno, Kai-Feng Chen, Y. Chao, B. Harrop, Kevin Varvell, Y. Nakahama, Y. Ushiroda, J. Dalseno, Y. Watanabe, Yongsun Kim, Samo Stanič, A. M. Bakich, Z. Natkaniec, H. Steininger, P. Križan, H. Matsumoto, Masashi Hazumi, S. Schmid, T. Kawasaki, Y. Choi, T. Arakawa, T. Hara, S. Ono, Marco Barbero, Y. Asano, S. Okuno, Kenji Hayashi, J. Schümann, Takuya Higuchi, M. H. Tanaka, M. Watanabe, D. Heffernan, Y. Yamashita, M. C. Chang, S. Koike, G. S. Varner, Nobuaki Sato, C. C. Wang, M. Pernicka, Tsukasa Aso, T. E. Browder, K. Hara, A. Kibayashi, T. Kameshima, H. Miyake, Samo Korpar, M. Rosen, Daniel Robert Marlow, K. Uchida, and Hitoshi Yamamoto

Subjects
Physics, Nuclear and High Energy Physics, Physics::Instrumentation and Detectors, business.industry, Detector, Electrical engineering, Readout electronics, Dead time, Silicon vertex detector, Belle experiment, B-factory, Crosstalk, Upgrade, Physics::Accelerator Physics, High Energy Physics::Experiment, business, Instrumentation
Abstract

The silicon vertex detector (SVD2) of the Belle experiment at KEK (Tsukuba, Japan) is currently close to its limits in terms of the occupancy of the innermost layer and the readout dead time. In order to cope with further increase in luminosity, different levels of upgrades are proposed: small improvements are possible in the short term by tuning the current system at the cost of signal-to-noise and crosstalk. In 2007, the two inner layers of the SVD2 will be replaced by similar detectors with faster readout electronics (SVD2.5) and in the long term, a major upgrade of the full silicon vertex detector (SVD3) is envisaged for the KEK Super B Factory. These upgrade scenarios will be discussed in detail from the hardware point of view along with the options under study.

Published
2006
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33. First observation of the decay τ−→ϕK−ντ

Author

V. Aulchenko, T. Lesiak, M. Starič, J. B. Singh, A. Drutskoy, Y. Iwasaki, I. Bizjak, V. Sidorov, T. Matsumoto, D. Liventsev, R. Seidl, R. Mizuk, P. Kapusta, T. Tsukamoto, A. Bozek, J. Haba, T. Iijima, Y. J. Kwon, S. Korpar, K. Abe, M. E. Sevior, Y. Miyazaki, O. Tajima, O. Schneider, H. Aihara, T. Aushev, I. Nakamura, A. M. Bakich, T. Ohshima, S. Fratina, T. E. Browder, Rakesh Kumar, H. Miyata, R. Itoh, H. Kawai, L. S. Peak, E. Nakano, M. Nakao, L. E. Piilonen, C.-H. Wu, Kazuhiko Hara, Bruce Yabsley, T. Schietinger, T. Hokuue, A. Bondar, Y. B. Hsiung, B. Shwartz, R. Kulasiri, H. Ozaki, Y. Nagasaka, S. Villa, Phillip Urquijo, S. Okuno, A. Chen, G. Varner, H. Stoeck, K. Senyo, S. Uno, Y. Usov, K. Ueno, I. Bedny, K. Arinstein, K. Hayasaka, A. Kuzmin, S. Y. Suzuki, H. Hayashii, Gobinda Majumder, S. Ogawa, A. Poluektov, G. Leder, X. C. Tian, H. R. Khan, D. Epifanov, D. Heffernan, H. Miyake, A. Somov, M. Danilov, S. McOnie, K. F. Chen, W. Mitaroff, O. Nitoh, A. Zupanc, P. Krokovny, Masayoshi Y. Tanaka, H. Ha, W. T. Chen, S. Stanič, T. Gershon, H. Shibuya, S. Bahinipati, M. Bračko, F. Mandl, N. Tamura, Toshisuke Kawasaki, V. Zhilich, H. Palka, A. Yamaguchi, Y. J. Kim, S. W. Lin, E. L. Barberio, S. Uehara, H. Park, H. Kichimi, A. Matyja, K. Inami, Ichiro Adachi, T. Uglov, Y. Choi, G. N. Taylor, M. Hazumi, R. Chistov, James Mueller, S. Nishida, N. Soni, Y. Teramoto, Y. Yamashita, E. Won, S. U. Kataoka, S. Eidelman, N. Gabyshev, D. Anipko, W. S. Hou, Long Zhang, Y. Onuki, M. Barbero, Young-Il Choi, G. Gokhroo, P. Križan, A. J. Schwartz, Y. Sakai, A. Ishikawa, Y. Hoshi, C. W. Park, S. Hou, J. H. Kang, and J. Dalseno

Subjects
Physics, Nuclear physics, Nuclear and High Energy Physics, Particle physics, Branching fraction, Hadron, Symbol (formal), Belle experiment, Lepton
Abstract

We present the first observation of τ lepton decays to hadronic final states with a ϕ -meson. This analysis is based on 401 fb −1 of data accumulated at the Belle experiment. The branching fraction obtained is B ( τ − → ϕ K − ν τ ) = ( 4.05 ± 0.25 ± 0.26 ) × 10 −5 .

Published
2006
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34. Belle SVD2 vertex detector

Author

H. Aihara, Y. Asano, T. Aso, A. Bakich, M. Barbero, T. Browder, M.C. Chang, Y. Chao, K.F. Chen, S. Chidzik, A. Chouvikov, J. Dalseno, R. Dowd, R. Fernholz, S. Fratina, M. Friedl, H. Fujii, Y. Fujiyama, J. Haba, K. Hara, T. Hara, B. Harrop, T. Haruyama, K. Hayashi, M. Hazumi, D. Heffernan, T. Higuchi, A. Igarashi, Y. Igarashi, H. Ikeda, H. Ishino, S. Iwaida, T. Kameshima, P. Kapusta, K. Kasami, T. Kawasaki, A. Kibayashi, S. Koike, S. Korpar, P. Križan, H. Kurashiro, A. Kusaka, T. Lesiak, D. Marlow, H. Matsumoto, Y. Mikami, H. Miyake, G.R. Moloney, Z. Natkaniec, S. Nozaki, R. Ohkubo, S. Okuno, S. Ono, Y. Onuki, W. Ostrowicz, H. Ozaki, L. Peak, M. Pernicka, M. Rosen, M. Rozanska, N. Sato, S. Schmid, J. Schümann, T. Shibata, R. Stamen, S. Stanič, H. Steininger, K. Sumisawa, J. Suzuki, H. Tajima, O. Tajima, K. Takahashi, F. Takasaki, N. Tamura, M. Tanaka, G.N. Taylor, K. Trabelsi, T. Tsuboyama, K. Uchida, K. Ueno, Y. Ushiroda, S. Vahsen, G. Varner, K. Varvell, Y.S. Velikzhanin, C.C. Wang, M.Z. Wang, M. Watanabe, Y. Watanabe, H. Yamamoto, Y. Yamashita, M. Yamauchi, R. Yang, Y. Yasu, T. Ziegler, and D. Žontar

Subjects
Vertex (graph theory), Physics, Nuclear and High Energy Physics, Particle physics, Belle experiment, Silicon vertex detector, law.invention, Nuclear physics, KEKB, Radiation tolerance, law, Physics::Accelerator Physics, High Energy Physics::Experiment, Vertex detector, Polar coordinate system, Collider, Instrumentation
Abstract

A new silicon vertex detector for the Belle experiment has been in operation at the high-luminosity asymmetric energy electron–positron collider KEKB since October 2003. It provides a larger polar angle acceptance, a better vertex resolution and a higher radiation tolerance than the previous one. The obtained performances indicate that the SVD2 works reliably, in very good agreement with expectations.

Published
2006
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35. Search for lepton flavor violating τ− decays with a KS0 meson

Author

Y. Miyazaki, K. Abe, H. Aihara, D. Anipko, K. Arinstein, V. Aulchenko, T. Aushev, A.M. Bakich, M. Barbero, I. Bedny, K. Belous, U. Bitenc, I. Bizjak, S. Blyth, A. Bondar, A. Bozek, M. Bračko, T.E. Browder, A. Chen, W.T. Chen, R. Chistov, Y. Choi, Y.K. Choi, A. Chuvikov, S. Cole, J. Dalseno, M. Danilov, M. Dash, J. Dragic, S. Eidelman, D. Epifanov, N. Gabyshev, T. Gershon, A. Gorišek, H. Ha, K. Hayasaka, H. Hayashii, M. Hazumi, D. Heffernan, T. Hokuue, Y. Hoshi, S. Hou, T. Iijima, A. Imoto, K. Inami, A. Ishikawa, R. Itoh, M. Iwasaki, Y. Iwasaki, J.H. Kang, P. Kapusta, H. Kawai, H.R. Khan, H. Kichimi, H.O. Kim, S. Korpar, P. Krokovny, R. Kumar, C.C. Kuo, A. Kuzmin, Y.-J. Kwon, J. Lee, T. Lesiak, S.-W. Lin, F. Mandl, T. Matsumoto, S. McOnie, W. Mitaroff, H. Miyake, H. Miyata, E. Nakano, M. Nakao, S. Nishida, O. Nitoh, S. Noguchi, S. Ogawa, T. Ohshima, T. Okabe, S. Okuno, Y. Onuki, H. Ozaki, H. Palka, H. Park, L.S. Peak, R. Pestotnik, L.E. Piilonen, A. Poluektov, Y. Sakai, T. Schietinger, O. Schneider, R. Seidl, K. Senyo, M.E. Sevior, M. Shapkin, H. Shibuya, B. Shwartz, V. Sidorov, J.B. Singh, A. Somov, N. Soni, S. Stanič, M. Starič, H. Stoeck, K. Sumisawa, T. Sumiyoshi, F. Takasaki, N. Tamura, M. Tanaka, G.N. Taylor, Y. Teramoto, X.C. Tian, T. Tsukamoto, S. Uehara, K. Ueno, T. Uglov, S. Uno, P. Urquijo, Y. Usov, G. Varner, S. Villa, C.C. Wang, C.H. Wang, Y. Watanabe, E. Won, A. Yamaguchi, Y. Yamashita, M. Yamauchi, L.M. Zhang, and V. Zhilich

Subjects
Nuclear physics, Physics, Nuclear and High Energy Physics, Particle physics, KEKB, Meson, Electron–positron annihilation, Supersymmetry, Flavor, Lepton
Abstract

We have searched for the lepton flavor violating decays τ- → l- KS 0 (l = e or μ), using a data sample of 281 fb-1 collected with the Belle detector at the KEKB e+ e- asymmetric-energy collider. No evidence for a signal was found in either of the decay modes, and we set the following upper limits for the branching fractions: B (τ- → e- KS 0) < 5.6 × 10-8 and B (τ- → μ- KS 0) < 4.9 × 10-8 at the 90% confidence level. These results improve the previously published limits set by the CLEO Collaboration by factors of 16 and 19, respectively. © 2006 Elsevier B.V. All rights reserved.

Published
2006
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36. Vertex detector for super Belle experiment

Author

M. Pernicka, Hirokazu Ishino, Masashi Hazumi, T. Tsuboyama, G. S. Varner, J. Haba, M. Friedl, D. Heffernan, M. Barbero, T. Kameshima, K. Trabelsi, T. Kawasaki, S. Ono, M. Watanabe, and Osamu Tajima

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, Luminosity (scattering theory), Physics::Instrumentation and Detectors, Detector, Belle experiment, law.invention, B-factory, Nuclear physics, Upgrade, KEKB, law, Physics::Accelerator Physics, High Energy Physics::Experiment, B meson, Collider, Instrumentation
Abstract

Using a high resolution silicon vertex detector and a large number of B meson decays, the Belle experiment has succeeded in measuring time-dependent CP asymmetry with high precision. To continue the search for physics beyond the standard model, an upgrade of the KEKB collider to a luminosity of 10 35 – 36 cm - 2 s - 1 is proposed. Such a luminosity upgrade will also require an upgraded (“Super”) Belle experiment. Discussions have started on the conceptual design for the silicon vertexing upgrade of this detector. Since the momenta of particles is not high in B factory operating at the ϒ ( 4 S ) resonance, it is important to avoid high occupancy while keeping the material budget low. A fast data acquisition system and radiation hardness are also required. In this report, the conceptual design of a vertex detector for the Super Belle experiment is shown. The status of R&D topics is also reported.

Published
2006
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37. Status of the Belle silicon vertex detector

Author

Z. Natkaniec, H. Aihara, Y. Asano, T. Aso, A. Bakich, T. Browder, M.C. Chang, Y. Chao, K.F. Chen, S. Chidzik, A. Chouvikov, J. Dalseno, R. Dowd, R. Fernholz, S. Fratina, M. Friedl, H. Fujii, Y. Fujiyama, J. Haba, K. Hara, T. Hara, B. Harrop, T. Haruyama, K. Hayashi, M. Hazumi, D. Heffernan, T. Higuchi, A. Igarashi, Y. Igarashi, H. Ikeda, H. Ishino, S. Iwaida, T. Kameshima, P. Kapusta, K. Kasami, T. Kawasaki, A. Kibayashi, S. Koike, S. Korpar, P. Križan, H. Kurashiro, A. Kusaka, T. Lesiak, D. Marlow, H. Matsumoto, Y. Mikami, H. Miyake, G.R. Moloney, S. Nozaki, R. Ohkubo, S. Okuno, S. Ono, Y. Onuki, W. Ostrowicz, H. Ozaki, L. Peak, M. Pernicka, M. Rosen, M. Rozanska, N. Sato, S. Schmid, J. Schümann, T. Shibata, R. Stamen, S. Stanič, H. Steininger, K. Sumisawa, J. Suzuki, H. Tajima, O. Tajima, K. Takahashi, F. Takasaki, N. Tamura, M. Tanaka, G.N. Taylor, K. Trabelsi, W. Trischuk, T. Tsuboyama, K. Uchida, K. Ueno, Y. Ushiroda, S. Vahsen, G. Varner, K. Varvell, Y.S. Velikzhanin, C.C. Wang, M.Z. Wang, M. Watanabe, Y. Watanabe, H. Yamamoto, Y. Yamashita, M. Yamauchi, R. Yang, Y. Yasu, T. Ziegler, and D. Žontar

Subjects
Physics, Nuclear and High Energy Physics, Vertex (computer graphics), Physics::Instrumentation and Detectors, business.industry, Detector, Dead time, Silicon vertex detector, law.invention, KEKB, Optics, law, High Energy Physics::Experiment, Collider, business, Instrumentation, Radiation hardening, Energy (signal processing)
Abstract

The old silicon vertex detector (SVD1) of the Belle detector, operating at the high-luminosity asymmetric energy e+e− collider KEKB, was replaced by an upgraded version (SVD2) in 2003. The new detector has modified geometry and redesigned readout electronics, providing a larger polar angle acceptance, better vertex resolution, improved radiation hardness and reduced dead time. The operation of the detector started successfully in October 2003. The basic concepts of the SVD2 design as well as its performance after 10 months of data taking are described in this paper.

Published
2006
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39. AN ALTERNATIVE METHOD FOR PREDICTING ATTRITION FROM AN ALCOHOL TREATMENT PROGRAMME

Author

John Davies, Dorothy D. Heffernan, Susan M. O'Connor, and Robert van Eijk

Subjects
Adult, Male, Predictive validity, medicine.medical_specialty, Patient Dropouts, Signal Detection, Psychological, media_common.quotation_subject, medicine, Humans, Attrition, Psychiatry, media_common, Alternative methods, Analysis of Variance, Reproducibility of Results, General Medicine, Middle Aged, Abstinence, medicine.disease, Response bias, Test (assessment), Alcoholism, ROC Curve, Vignette, Categorization, Patient Compliance, Female, Substance Abuse Treatment Centers, Psychology, Forecasting
Abstract

Aims: To test the predictive validity of a vignette methodology based on a Signal Detection model by examining treatment attrition within an alcohol clinic. Methods: Participants were asked to categorize vignettes that described individuals drinking alcohol as problem or nonproblem alcohol use at the beginning of a 4-week intensive course of treatment. These participants were divided retrospectively into two groups: those who completed treatment and those who dropped-out of treatment. A matched post-treatment long-term abstainer group was also tested. Results: Signal Detection analyses demonstrated that response bias scores predicted who would drop out of treatment (P = 0.01). Conclusions: The vignette methodology provided useful levels of prediction in an applied clinical setting. It was argued that verbal reports from problem alcohol users may be more usefully conceptualized in terms of sensitivity and response bias than in terms of memory or 'truth'.

Published
2003
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40. The impact of verbal feedback about blushing on social discomfort and facial blood flow during embarrassing tasks

Author

Tenille E Zekas, Tanya D Heffernan, Nina Formentin, Peter D. Drummond, Lara Camacho, and Fiona Williams

Subjects
Adult, Adolescent, Feedback, Psychological, media_common.quotation_subject, Blushing, Embarrassment, Experimental and Cognitive Psychology, Developmental psychology, Nonverbal communication, medicine, Humans, Psychological testing, Active listening, Forehead, media_common, Psychiatric Status Rating Scales, Psychological Tests, Social anxiety, Middle Aged, Social relation, Psychiatry and Mental health, Clinical Psychology, Regional Blood Flow, Data Interpretation, Statistical, Anxiety, Female, medicine.symptom, Psychology, Social Adjustment
Abstract

To investigate whether verbal feedback about blushing influences subsequent social discomfort or blushing itself, changes in facial blood flow and ratings of blushing and embarrassment were investigated in high (N=28) and low scorers (N=28) on the Blushing Propensity scale while singing and reading aloud, and while listening to audiotapes of their performance. After each task half of the participants were told that they had blushed, and the rest were told that they had not blushed. Blood flow increased progressively in participants with high blushing propensity scores who were given "blushing" feedback, but not in the other participants. This finding suggests that expecting to blush may become a self-fulfilling prophecy. Verbal feedback about blushing strongly influenced subsequent social discomfort, and mimicked the effects of blushing propensity on ratings of embarrassment and blushing intensity. In sum, the findings support the view that preconceptions about blushing propensity are shaped by past learning experiences, that concern about blushing is a major source of discomfort in embarrassing situations, and that these concerns are often unrelated to the actual intensity of blushing.

Published
2003
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41. Opening Spaces through Relocalization: Locating Potential Resistance in the Weaknesses of the Global Food System

Author

Mary K. Hendrickson and William D. Heffernan

Subjects
Consumption (economics), Economic growth, Sociology and Political Science, business.industry, Outreach, Food chain, Agriculture, Agency (sociology), Situated, Economics, Food systems, Marketing, business, Strengths and weaknesses
Abstract

In this paper we explore several themes based on our intertwined research and outreach activities. First, we examine and discuss emerging global food chains that are embedded in strategic alliances, joint ventures and relationships - in short in networks of power. Decisions are being displaced away from multiple actors situated in different localities to globalized decision-making located within a few firms that make up each cluster. While the roots of these phenomena are firmly grounded in long-term historical processes, it is important to document and understand what is emerging at the global level in order to create alternatives. Second, we discuss our outreach work with farmers, consumers and communities in helping them to frame and understand the changes that are taking place in the food and agriculture system. This is exemplified through a case study of the Kansas City Food Circle and its role in generating alternative visions from the consumption side of the food equation. This work is extremely important for challenging the global food system, and also for helping to empower farmers, eaters and communities to create alternatives. We lay out an analytical understanding of the strengths and weaknesses of the global system, and the opportunities found in the social, environmental and economic failures of the global system. In conclusion, the work described above rests on the recognition of different forms of agency that are appearing in the food system, agency that is located within the spaces provided by the unsustainable, unjust nature of the global system. We remain cognizant of the incredible networks of power that shape the production and consumption relationships in the food system. However, we remain hopeful that models of emerging alternatives can help relocalize production/consumption relationships in the food system in equitable ways. In other words, in relationships that are personalized and sustainable, and that are embedded in place and community

Published
2002
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42. JPC-2997, a new aminomethylphenol with high in vitro and in vivo antimalarial activities against blood stages of Plasmodium

Author

Arba L. Ager, Geoffrey W. Birrell, Kurt W. Saionz, Hong Ming Shieh, Gavin D. Heffernan, G. Dennis Shanks, Laura R. Jacobus, Jacek Terpinski, Peter E. Krasucki, Guy A. Schiehser, Wenyi Zhao, Michael D. Edstein, David P. Jacobus, and Marina Chavchich

Subjects
Plasmodium berghei, Pyridines, Plasmodium falciparum, Drug Resistance, Pharmacology, Cell Line, Antimalarials, Mice, Pharmacokinetics, Parasitic Sensitivity Tests, Phenols, In vivo, Chloroquine, Cricetinae, medicine, Potency, Animals, Humans, Pharmacology (medical), Malaria, Falciparum, Volume of distribution, biology, Hep G2 Cells, biology.organism_classification, Effective dose (pharmacology), Infectious Diseases, HEK293 Cells, Susceptibility, Aotidae, Plasmodium vivax, medicine.drug
Abstract

4-( tert -Butyl)-2-(( tert -butylamino)methyl)-6-(6-(trifluoromethyl)pyridin-3-yl)-phenol (JPC-2997) is a new aminomethylphenol compound that is highly active in vitro against the chloroquine-sensitive D6, the chloroquine-resistant W2, and the multidrug-resistant TM90-C2B Plasmodium falciparum lines, with 50% inhibitory concentrations (IC 50s ) ranging from 7 nM to 34 nM. JPC-2997 is >2,500 times less cytotoxic (IC 50 s > 35 μM) to human (HepG2 and HEK293) and rodent (BHK) cell lines than the D6 parasite line. In comparison to the chemically related WR-194,965, a drug that had advanced to clinical studies, JPC-2997 was 2-fold more active in vitro against P. falciparum lines and 3-fold less cytotoxic. The compound possesses potent in vivo suppression activity against Plasmodium berghei , with a 50% effective dose (ED 50 ) of 0.5 mg/kg of body weight/day following oral dosing in the Peters 4-day test. The radical curative dose of JPC-2997 was remarkably low, at a total dose of 24 mg/kg, using the modified Thompson test. JPC-2997 was effective in curing three Aotus monkeys infected with a chloroquine- and pyrimethamine-resistant strain of Plasmodium vivax at a dose of 20 mg/kg daily for 3 days. At the doses administered, JPC-2997 appeared to be well tolerated in mice and monkeys. Preliminary studies of JPC-2997 in mice show linear pharmacokinetics over the range 2.5 to 40 mg/kg, a low clearance of 0.22 liters/h/kg, a volume of distribution of 15.6 liters/kg, and an elimination half-life of 49.8 h. The high in vivo potency data and lengthy elimination half-life of JPC-2997 suggest that it is worthy of further preclinical assessment as a partner drug.

Published
2014

43. Consolidation in food retailing and dairy

Author

William D. Heffernan, Judith B. Heffernan, Philip H. Howard, and Mary K. Hendrickson

Subjects
Consolidation (business), Horizontal integration, Restructuring, business.industry, Supply chain, Food processing, Business, Management and Accounting (miscellaneous), Dairy industry, Business, Marketing, Industrial organization, Food Science
Abstract

Discusses the restructuring of the food production, processing and retailing sectors in the USA. Describes different methods of vertical and horizontal integration that have occurred. Goes on to discuss the consolidation of business in retailing in particular. Refers to the relationships that are being formed between the supermarket chains, for example Wal‐Mart and Kroger, and dominant food‐chain clusters. Considers whether or not smaller retail chains and wholesalers should feel threatened by this consolidation. Takes the dairy sector in the USA as a case study in the restructuring of the retailing and processing sectors.

Published
2001
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44. Virtually reducing product development time

Author

T. Hogan and D. Heffernan

Subjects
Engineering, business.industry, Ic manufacture, Mechanical Engineering, Product testing, Product engineering, Industrial and Manufacturing Engineering, Manufacturing engineering, Test (assessment), Product lifecycle, New product development, Key (cryptography), Virtual test, Electrical and Electronic Engineering, business, Information Systems
Abstract

The speed at which semiconductor products are introduced to the market-place is key to the competitive success of individual companies. The authors look at the test engineering aspect of the IC and describe how a 'virtual test' can be effectively applied to reduce the overall product development time.

Published
2001
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45. Virtual test reduces semiconductor product development time

Author

D. Heffernan and T. Hogan

Subjects
Engineering, Virtual instrumentation, Computer Networks and Communications, business.industry, Integrated circuit, Industrial engineering, Product engineering, Manufacturing engineering, law.invention, Product (business), Product lifecycle, Semiconductor, law, Management of Technology and Innovation, New product development, Key (cryptography), Virtual test, Electronics, Electrical and Electronic Engineering, business
Abstract

In the semiconductor industry's evolutionary life cycle, the speed at which products are introduced to the market-space is key to the competitive success of individual companies. The semiconductor industry is classed as a fast-changing industry in which product technology, manufacturing process technology and industry organisation need to be continuously updated in relatively short cycle times. This paper looks at the test engineering aspect of the IC (integrated circuit) product development process and describes how an emerging 'virtual test' methodology can be effectively, applied to reduce the overall product development time for semiconductor devices.

Published
2001
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46. The Tuna-Dolphin Controversy

Author

Alessandro Bonanno, William D. Heffernan, and Douglas H. Constance

Subjects
Economic restructuring, Sociology and Political Science, Agriculture, business.industry, 0502 economics and business, 05 social sciences, 050602 political science & public administration, Mode (statistics), 050207 economics, Economic system, business, Tuna, 0506 political science
Abstract

This study uses the case of the tuna-dolphin controversy to inform discussions in the sociology of agriculture regarding global post-Fordism in general and the new mode of regulation in particular. Global post-Fordism is defined as the global economic restructuring in progress and the associated emergence of transnational corporations (TNCs) and transnational-States. Mode of regulation is the historically specific set of social norms that are institutionalized within civil society—primarily by the State—whose regularity underpins continued accumulation.

Published
1995
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47. Global contested terrain: The case of the tuna-dolphin controversy

Author

Douglas H. Constance, William D. Heffernan, and Alessandro Bonanno

Subjects
Latin Americans, media_common.quotation_subject, Legislature, Legislation, Terrain, Public administration, Globalization, State (polity), Political economy, Threatened species, Sociology, Agronomy and Crop Science, Social movement, media_common
Abstract

Employing the case of the global tuna-fish industry, it is argued that the process of globalization is contested terrain as it opens “free spaces” to some classes or groups and closes “free spaces” to others; that the nation-States' regulatory abilities are weakened; and finally, that while some social movements may gain, others are marginalized. Three basic conclusions are reached. (1) The industry's actions were successfully “contested” by environmental groups supported by the legislative and judicial branches of the US State. (2) Simultaneously, pro-environmental legislation is currently threatened, along with several national and international environmental accords. (3) Workers in the US and, particularly, in Latin America are paying the consequences of the introduction of pro-environmental legislation and the actions of transnational corporations (TNCs).

Published
1995
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48. Stereoselective synthesis of a synthon for the A-ring of taxol from R-(+)-verbenone

Author

Jeffrey D. Winkler, Fina. Liotta, Samit K. Bhattacharya, Cladingboel David, Gavin D. Heffernan, Kelly Robert C, and Robert A. Batey

Subjects
chemistry.chemical_classification, Taxane, Bicyclic molecule, Stereochemistry, Organic Chemistry, Synthon, Ring (chemistry), Biochemistry, Combinatorial chemistry, chemistry.chemical_compound, chemistry, Drug Discovery, Stereoselectivity, Verbenone, Lactone
Abstract

The efficient conversion of R-(+)-verbenone to bicyclic lactone 6 , a potentially useful intermediate for the synthesis of taxanes, is described. The introduction of C-1 (taxane numbering) oxygen functionality is also reported, thereby completing the synthesis of the A-ring subunit of taxol.

Published
1995
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49. Erratum: Measurement of azimuthal asymmetries in inclusive production of hadron pairs ine+e−annihilation ats=10.58 GeV[Phys. Rev. D78, 032011 (2008)]

Author

E. Nakano, H. O. Kim, M. Shapkin, Robin Wedd, Y. J. Kim, Y. Watanabe, H. Hayashii, Hyunyong Kim, L. S. Peak, T. Lesiak, W. Bartel, M. Dash, K. Senyo, Y. Sakai, J. G. Shiu, A.E. Bondar, T. Kawasaki, V.N. Zhilich, H. Kaji, Phillip Urquijo, M. Tanaka, T. Sumiyoshi, Jeremy Dalseno, B. Golob, D. Liventsev, I. S. Cho, Antonio Limosani, I. Tikhomirov, A. Chen, G. S. Varner, T. E. Browder, M. Starič, R. Mizuk, J. S. Lange, B. G. Cheon, Rajesh Kumar, C. H. Wang, P. Wang, D. Heffernan, Tatiana Medvedeva, J. Li, Y. I. Kim, G. R. Moloney, Y. Chao, K. Miyabayashi, H. K. Park, Y. Yamashita, Jolanta Brodzicka, S. Nishida, F. Mandl, M. Grosse Perdekamp, W. S. Hou, Y. Iwasaki, K. Vervink, Y. J. Kwon, M. E. Sevior, Masashi Hazumi, U. Bitenc, S. H. Kyeong, O. Schneider, X. L. Wang, S. Uno, J. S. H. Lee, S. Okuno, H. Sahoo, A. Ogawa, T. Uglov, O. Zyukova, C. P. Shen, S. Eidelman, Y. Teramoto, Bruce Yabsley, P. Pakhlov, J. B. Singh, H. J. Hyun, S. Ogawa, Seema Bahinipati, H. Park, A. Bozek, A. Drutskoy, Y. Choi, C. W. Park, E. Won, H. Miyake, Y. Miyazaki, H. Nakazawa, A. Sekiya, Samo Stanič, M. J. Lee, M. Bračko, A. M. Bakich, T. Ohshima, N. Gabyshev, A. Ishikawa, P. Križan, I. Adachi, S. Uehara, H. Ha, Y. Unno, C. Liu, A. Zupanc, O. Nitoh, H. Palka, L. E. Piilonen, G. Pakhlova, D. H. Kah, R. Chistov, R. Seidl, T. Zivko, S. McOnie, H. Miyata, Y. Hoshi, H. Aihara, Y. Usov, K. Hayasaka, Z. P. Zhang, and Hikaru Kawai

Subjects
Physics, Quark, Nuclear and High Energy Physics, Particle physics, Propagation of uncertainty, Annihilation, media_common.quotation_subject, Monte Carlo method, Table (information), Asymmetry, Baryon, Nuclear physics, Charm (quantum number), media_common
Abstract

In the original article, it was found in Monte Carlo simulations that the reconstructed A₀ results are roughly consistent with the generated asymmetries, while the A₁₂ results systematically underestimate the generated asymmetries. This underestimation can be attributed to the difference between the reconstructed thrust axis and the original quark-antiquark axis. The corresponding correction factors are 1.6 ± 0.04 for the A₁₂ results and 1.11 ± 0.05 for the A₀ results. Because of a flaw in the original analysis program, these correction factors were not applied to the AUC-type asymmetries in Table V as well as in some figures. In addition, a small mistake in the error propagation in the charm correction resulted in slightly underestimated statistical uncertainties. These omissions affect all but the charm asymmetry results. The correct central values are therefore given in Tables IV and V of this Erratum. The systematic uncertainties of the original publication remain unchanged.

Published
2012
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50. Synthesis of 1,2-anhydro-3,4,5,-tri-O-benzyl-β-d-fructopyranose

Author

Malcolm M. Campbell, Terence Lewis, and Gavin D. Heffernan

Subjects
Anomer, Stereochemistry, Organic Chemistry, Epoxide, General Medicine, Carbon-13 NMR, Ring (chemistry), Biochemistry, Medicinal chemistry, Analytical Chemistry, chemistry.chemical_compound, chemistry, Reagent, Imidazole, Halohydrin, Triphenylphosphine
Abstract

A synthesis of the anomeric spiro-epoxide 15 from d -fructose in 7 steps in an overall 13% yield, is described. The key intermediate in the synthesis, 3,4,5,-tri-O-benzyl-1-deoxy-1-iodo-β- d -fructopyranose (14), was prepared from the corresponding methyl fructopyranoside by reaction with the iodine-triphenylphosphine-imidazole reagent complex, followed by acid hydrolysis. Ring closure of the iodohydrin 14 was achieved under extremely mild conditions on treatment with silver(I) oxide in anhydrous THF. The 13C NMR spectrum of 15 exhibited a large upfield shift of the resonances assigned to C-1 and C-2, indicative of an oxirane ring involving these two carbon atoms.

Published
1994
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