17 results on '"D. Zilli"'
Search Results
2. Author response for 'HumBug – An Acoustic Mosquito Monitoring Tool for use on budget smartphones'
- Author
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E. Herreros‐Moya, S. Roberts, D. Zilli, W. Rafique, Y. Li, I. Kiskin, M. E Sinka, H. Portwood, L. Wang, H. Chan, K. J. Willis, B. Gutteridge, and D. Kirkham
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Computer science ,Monitoring tool ,Data science - Published
- 2021
3. When AI needs to work smarter, not harder [opinion - first person]
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D. Zilli
- Subjects
Electrical and Electronic Engineering - Published
- 2022
4. Room temperature hydrogen gas sensor nanocomposite based on Pd-decorated multi-walled carbon nanotubes thin films
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Pablo Ricardo Bonelli, Ana Lea Cukierman, and D. Zilli
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Materials science ,Scanning electron microscope ,INGENIERÍAS Y TECNOLOGÍAS ,Chemical vapor deposition ,Carbon nanotube ,NANOCOMPOSITE ,PALLADIUM NANOPARTICLES ,Hydrogen sensor ,law.invention ,Electrical resistance and conductance ,Electrical resistivity and conductivity ,law ,MULTI-WALLED CARBON NANOTUBE ,Materials Chemistry ,Electrical and Electronic Engineering ,Thin film ,PURIFICATION EFFECT ,Instrumentation ,HYDROGEN SENSOR ,Nanotecnología ,Nanocomposite ,Metals and Alloys ,Nano-materiales ,Condensed Matter Physics ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Chemical engineering - Abstract
Multi-walled carbon nanotubes (MWCNTs) are successfully processed in the form of thin films (buckypapers), and their morphology and electrical behaviour are characterized. The MWCNTs are synthesized by the floating catalyst chemical vapour deposition process. The effects of a sequence of treatments applied for MWCNTs purification on the buckypapers electrical behaviour are also examined. Nanocomposite thin films constituted of pristine and purified MWCNTs and Pd nanoparticles are prepared in order to evaluate their viability as H 2 sensors at room temperature. For this purpose, the electrical resistance of the nanocomposite films in atmospheres with different H 2 concentrations, is determined. Scanning electron microscopy (SEM) images show that the buckypapers and the nanocomposite films are 2D structures constituted by randomly oriented MWCNTs. The buckypapers present a semiconductor-like electrical behaviour as determined by the standard four point method. Room temperature resistivity values of around 10 -3 Ω m are assessed. Nanocomposite films show different electrical behaviour depending on the purification treatment applied to the MWCNTs employed. Furthermore, the electrical resistance of the nanocomposite films is found to increase when the measurements are performed in H 2 atmosphere. Values of H 2 sensitivity at room temperature of the nanocomposite films up to 2.15% are determined for H 2 average concentration higher than 350 ppm with short recovery time. Fil: Zilli, Dario Adrian. Universidad de Buenos Aires. Programa de Investigación y Desarrollo de Fuentes Alternativas de Materias Primas y Energía; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Bonelli, Pablo Ricardo. Universidad de Buenos Aires. Programa de Investigación y Desarrollo de Fuentes Alternativas de Materias Primas y Energía; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Cukierman, Ana Lea. Universidad de Buenos Aires. Programa de Investigación y Desarrollo de Fuentes Alternativas de Materias Primas y Energía; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
- Published
- 2011
5. A specific heat anomaly in multiwall carbon nanotubes as a possible sign of orientational order–disorder transition
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Silvia Goyanes, Victoria Bekeris, Guillermo Jorge, Roberto Candal, Mariano Martin Escobar, Ana Lea Cukierman, and D. Zilli
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Range (particle radiation) ,Fusion ,Materials science ,Condensed matter physics ,Degrees of freedom (physics and chemistry) ,General Chemistry ,Carbon nanotube ,Magnetic field ,law.invention ,Condensed Matter::Materials Science ,Hysteresis ,Structural change ,law ,General Materials Science ,Anomaly (physics) - Abstract
We present micro-calorimetric specific heat measurements on different multiwall carbon nanotubes of large outer diameter, as a function of temperature in the range 10–120 K. A clear anomaly at 60 K with the shape of a peak is present in two of the samples, and both the height and the characteristic temperature of the peak are independent of magnetic field and do not exhibit thermal hysteresis, discarding magnetic degrees of freedom related to Fe seeds or contributions from adsorbed gases. These features suggest that the anomaly may be caused by a structural change. As the anomaly is also unaffected by induced intertube disorder, it may be related with a melting of orientational dislocations of individual tubes within multiwall nanotubes, an effect that was theoretically predicted to occur in carbon nanotubes and represents a distinctive feature of asymmetric molecular systems.
- Published
- 2010
6. Formation mechanism of Y-junctions in arrays of multi-walled carbon nanotubes
- Author
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Jean-Paul Pirard, Silvia Blacher, D. Zilli, Cédric Gommes, and Ana Lea Cukierman
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Materials science ,Catalytic chemical vapor deposition ,chemistry.chemical_element ,Nanotechnology ,Carbon nanotube ,Condensed Matter::Mesoscopic Systems and Quantum Hall Effect ,Molecular physics ,law.invention ,Metal ,Colloid and Surface Chemistry ,chemistry ,Transmission electron microscopy ,law ,Condensed Matter::Superconductivity ,visual_art ,visual_art.visual_art_medium ,Electron microscope ,Carbon ,Metal particle - Abstract
Transmission electron microscopy of arrays of multi-walled carbon nanotubes reveals the presence of numerous Y-junctions. The diameter distributions of the samples are found to be bimodal, with one mode corresponding to the branches and the other mode to the trunk of the Y-junctions. The analysis of the micrographs shows that the junctions form via the merger of metal particles during the tip-growth of the
- Published
- 2008
7. Comparative analysis of electric, magnetic, and mechanical properties of epoxy matrix composites with different contents of multiple walled carbon nanotubes
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Gerardo Hector Rubiolo, C. Chiliotte, A. L. Cukierman, D. Zilli, Mariano Martin Escobar, Victoria Bekeris, and Silvia Goyanes
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Materials science ,Polymers and Plastics ,Sonication ,Nanoparticle ,Concentration effect ,Percolation threshold ,General Chemistry ,Epoxy ,Carbon nanotube ,law.invention ,law ,visual_art ,Materials Chemistry ,Ceramics and Composites ,visual_art.visual_art_medium ,Composite material ,Porosity ,Mass fraction - Abstract
Epoxy composites based on aligned chemical vapor deposition–grown multiwall carbon nanotubes (MWCNTs), containing trapped iron nanoparticles, with weight fractions ranging from 0.03 to 1 wt%, were produced following a well-known processing way. Electrical and mechanical properties as well as their densities were measured. The results are compared with previous studies investigating the magnetic percolation behavior in the same samples of composites. A percolation threshold at 0.4 wt% of MWCNTs was determined by the electrical property and it agrees with the threshold observed in the magnetic properties. A hop in the porosity and a depression of the bulk mechanical properties were also found at the threshold value. These results point out that there is an efficiency threshold related to the sonication stage of the fabrication process and the weight fraction of MWCNTs, and after this threshold, the initial nanotubes pans were not separated into individual MWCNTs or into small ropes. An optimized sonication stage is proposed and the improvement in the dispersion of the filler is shown. POLYM. COMPOS., 28:612–617, 2007. © 2007 Society of Plastics Engineers
- Published
- 2007
8. Carbon nanotubes buckypapers for potential transdermal drug delivery
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Alex Schwengber, D. Zilli, Ana Lea Cukierman, Pablo Ricardo Bonelli, and Héctor Juan Prado
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Drug ,Paper ,Materials science ,CIENCIAS MÉDICAS Y DE LA SALUD ,Chemical structure ,media_common.quotation_subject ,Ciencias de la Salud ,Bioengineering ,Nanotechnology ,Buckypaper ,Carbon nanotube ,INGENIERÍAS Y TECNOLOGÍAS ,BUCKYPAPERS ,Administration, Cutaneous ,FLURBIPROFEN ,CARBON NANOTUBES ,law.invention ,Biomaterials ,Diffusion ,Nanopores ,Differential scanning calorimetry ,Nanocapsules ,law ,Materials Testing ,Particle Size ,media_common ,Transdermal ,Nanotecnología ,Nanotubes, Carbon ,Anti-Inflammatory Agents, Non-Steroidal ,TRANSDERMAL DRUG DELIVERY ,Nano-materiales ,Amorphous solid ,CLONIDINE HYDROCHLORIDE ,Otras Ciencias de la Salud ,Absorption, Physicochemical ,Flurbiprofen ,Mechanics of Materials ,Delayed-Action Preparations ,Surface modification ,Feasibility Studies ,Fullerenes - Abstract
Drug loaded buckypapers based on different types of carbon nanotubes (CNTs) were prepared and characterized in order to evaluate their potentialities for the design of novel transdermal drug delivery systems. Lab-synthesized CNTs as well as commercial samples were employed. Clonidine hydrochloride was used as model drug, and the influence of composition of the drug loaded buckypapers and processing variables on in vitro release profiles was investigated. To examine the influence of the drug nature the evaluation was further extended to buckypapers prepared with flurbiprofen and one type of CNTs, their selection being based on the results obtained with the former drug. Scanning electronic microscopy images indicated that the model drugs were finely dispersed on the CNTs. Differential scanning calorimetry, and X-ray diffraction pointed to an amorphous state of both drugs in the buckypapers. A higher degree of CNT-drug superficial interactions resulted in a slower release of the drug. These interactions were in turn affected by the type of CNTs employed (single wall or multiwall CNTs), their functionalization with hydroxyl or carboxyl groups, the chemical structure of the drug, and the CNT:drug mass ratio. Furthermore, the application of a second layer of drug free CNTs on the loaded buckypaper, led to decelerate the drug release and to reduce the burst effect. Fil: Schwengber, Alex. Universidad de Buenos Aires. Programa de Investigación y Desarrollo de Fuentes Alternativas de Materias Primas y Energía; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Prado, Héctor Juan. Universidad de Buenos Aires. Programa de Investigación y Desarrollo de Fuentes Alternativas de Materias Primas y Energía; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Zilli, Dario Adrian. Universidad de Buenos Aires. Programa de Investigación y Desarrollo de Fuentes Alternativas de Materias Primas y Energía; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Bonelli, Pablo Ricardo. Universidad de Buenos Aires. Programa de Investigación y Desarrollo de Fuentes Alternativas de Materias Primas y Energía; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Cukierman, Ana Lea. Universidad de Buenos Aires. Programa de Investigación y Desarrollo de Fuentes Alternativas de Materias Primas y Energía; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
- Published
- 2015
9. Effect of alignment on adsorption characteristics of self-oriented multi-walled carbon nanotube arrays
- Author
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Ana Lea Cukierman, P R Bonelli, and D Zilli
- Subjects
In situ ,Materials science ,Mechanical Engineering ,Sonication ,Inorganic chemistry ,Iron phthalocyanine ,chemistry.chemical_element ,Bioengineering ,General Chemistry ,Carbon nanotube ,Chemical vapor deposition ,law.invention ,Adsorption ,Volume (thermodynamics) ,chemistry ,Chemical engineering ,Mechanics of Materials ,law ,General Materials Science ,Electrical and Electronic Engineering ,Cobalt - Abstract
The adsorption characteristics of self-oriented multi-walled carbon nanotube (MWCNT) arrays are examined from N2 (−196 °C) adsorption measurements. The arrays were synthesized in a laboratory by in situ chemical vapour deposition of iron or cobalt phthalocyanines at 880 and 950 °C, under otherwise constant conditions, in an attempt to obtain different morphological structures. For both precursors, increasing the temperature leads to MWCNT arrays with lower Brunauer–Emmett–Teller (BET) surface area and total pore volume, though the effect is more pronounced for those arising from the iron-based compound. Despite this, precursor yields of individual nanotubes of larger diameter, higher BET area and total pore volume characterize the resulting arrays compared to those arising from cobalt phthalocyanine for the same temperatures. As evidenced by SEM and TEM images, the arrays synthesized from iron phthalocyanine at 880 °C show better vertical alignment and denser structures than those obtained from this compound at 950 °C, and also from cobalt phthalocyanine at both temperatures. Further ultrasonication of the arrays produced from the iron compound brings about a significant reduction in their adsorption capacity, attributable to the pronounced disarrangement of the resulting structures. The present results demonstrate that the alignment of MWCNT arrays plays a crucial role in their N2 adsorption characteristics.
- Published
- 2006
10. Magnetic properties of multi-walled carbon nanotube–epoxy composites
- Author
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G.R. Rubiolo, Victoria Bekeris, Mariano Martin Escobar, Silvia Goyanes, A. L. Cukierman, D. Zilli, and C. Chiliotte
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Nanocomposite ,Materials science ,Polymers and Plastics ,Organic Chemistry ,Nanoparticle ,Epoxy ,Carbon nanotube ,Coercivity ,Magnetic hysteresis ,law.invention ,Ferromagnetism ,Remanence ,law ,visual_art ,Materials Chemistry ,visual_art.visual_art_medium ,Composite material - Abstract
Epoxy matrix composites have been prepared using as filler different weight fractions (0.03–1 wt%) of CVD grown multi-walled carbon nanotubes (MWCNTs) containing trapped iron nanoparticles. Magnetic characterization performed at room temperature with magnetic field between K19 and 19 kG shows that the nanocomposites are weakly ferromagnetic at room temperature. An abrupt variation in the dependence of both the coercivity field, BC, and remanent magnetization, MR, with the weight fraction of MWCNTs, f, was found for fZ 0.4%. Results suggest the formation of MWCNTs agglomerates for increasing weight concentrations, in accordance with SEM micrographs. q 2005 Elsevier Ltd. All rights reserved.
- Published
- 2005
11. HST and ground-based eclipse observations of V2051 Ophiuchi: binary parameters
- Author
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Keith Horne, M. S. Catalán, Raymundo Baptista, and D. Zilli
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Physics ,Brightness ,Astrophysics (astro-ph) ,FOS: Physical sciences ,White dwarf ,Astronomy and Astrophysics ,Astrophysics ,Mass ratio ,Spectral line ,Photometry (optics) ,Stars ,Space and Planetary Science ,Emission spectrum ,Dwarf nova - Abstract
We report on high-speed eclipse photometry of the dwarf nova V2051 Oph while it was in a low brightness state, at B ~ 16.2 mag. In comparison to the average IUE spectra, the ultraviolet continuum and emission lines appear reduced by factors of, respectively, ~4 and ~5. Flickering activity is mostly suppressed and the lightcurve shows the eclipse of a compact white dwarf at disc centre which contributes ~60 per cent of the total light at 3900--4300 A. We use measurements of contact phases in the eclipse lightcurve to derive the binary geometry and to estimate masses and relevant dimensions. We find a mass ratio of q= 0.19+/-0.03 and an inclination of i= 83+/-2 degrees. The masses of the component stars are M_1 = 0.78+/-0.06 M_dot and M_2 = 0.15+/-0.03 M_dot. Our photometric model predicts K_1 = 83+/-12 km/s and K_2= 435+/-11 km/s. The predicted value of K_1 is in accordance with the velocity amplitude obtained from the emission lines after a correction for asymmetric line emission in the disc is made (Watts et al. 1986). The secondary of V2051 Oph is significantly more massive than the secondaries of the other ultra-short period dwarf novae. V2051 Oph is probably a relatively young system, whose secondary star had not enough time to evolve out of thermal equilibrium., Comment: 16 pages, 7 postscript figures, coded using MNRAS latex style. To appear in Monthly Notices of the Royal Astronomical Society. Revised version with changes in section 4.3. For related papers and files see ftp://fsc01.fsc.ufsc.br/pub/bap and http://www.fsc.ufsc.br/~astro
- Published
- 1998
12. Mast cell‐deficient mice Mcpt5Cre/Dicer fl/fl redefine the role of mast cells in experimental bullous pemphigoid
- Author
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S. Nsiah‐Dosu, C. Scholz, Z. Orinska, C. D. Sadik, R. J. Ludwig, E. Schmidt, D. Zillikens, and K. Hartmann
- Subjects
Dermatology ,RL1-803 - Abstract
Abstract Background Bullous pemphigoid (BP) is the most frequent autoimmune blistering disease of the skin affecting the elderly. BP is immunopathologically characterized by autoantibodies against BP180 and BP230. With the growing evidence of cell‐mediated autoimmunity in the pathogenesis of BP, it still remains unclear whether mast cells (MCs) are involved, due to conflicting data obtained from Kit‐dependent MC‐deficient mouse models. Objectives To clarify the role of MCs in experimental BP; the dynamics in cutaneous MC numbers, associated immune cells and the development of disease in Kit‐independent MC‐deficient mouse model. Methods Employing a recently established murine adult passive transfer model of BP induced by the transfer of pathogenic immunoglobulin G (IgG), lesional skin biopsies were investigated histologically and immunohistochemically for the time‐dependent MC accumulation and dermal infiltration. Results The numbers of cutaneous MCs increased following the induction of BP, in part, maintained by MC proliferation. Numbers of T cells, neutrophils and eosinophils in the skin also increased after BP induction, with eosinophils showing a preferential co‐localization with MCs. Furthermore, clinical disease manifestation in MC‐deficient Mcpt5Cre/Dicer fl/fl mice remained unchanged compared to MC‐sufficient Dicer fl/fl mice. The composition of the immune cell infiltration including as T cells, neutrophils and eosinophils was largely unaffected by the absence of MCs. Conclusion MCs do not play a pivotal role in the pathogenesis of passive IgG‐transfer mediated BP model. Their increase in number may be a bystander effect following tissue injury. We therefore suggest caution regarding the selection of MCs as sole targets for the development of novel drugs for BP.
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- 2022
- Full Text
- View/download PDF
13. Outpatient health care statistics data warehouse--implementation
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D, Zilli
- Subjects
Information Management ,Cost-Benefit Analysis ,Ambulatory Care ,Humans ,Mathematical Computing ,Online Systems ,Decision Support Techniques - Abstract
Data warehouse implementation is assumed to be a very knowledge-demanding, expensive and long-lasting process. As such it requires senior management sponsorship, involvement of experts, a big budget and probably years of development time. Presented Outpatient Health Care Statistics Data Warehouse implementation research provides ample evidence against the infallibility of the above statements. New, inexpensive, but powerful technology, which provides outstanding platform for On-Line Analytical Processing (OLAP), has emerged recently. Presumably, it will be the basis for the estimated future growth of data warehouse market, both in the medical and in other business fields. Methods and tools for building, maintaining and exploiting data warehouses are also briefly discussed in the paper.
- Published
- 2000
14. The use of adhesive elastic tape for hand oedema control in patients with a wrist fracture treated in a cast: A pilot study.
- Author
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Guasconi M, Zilli Riboni D, Civardi A, Bolzoni M, Granata C, Beretta M, Genovese A, Mozzarelli F, Quattrini F, and Maniscalco P
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- Humans, Pilot Projects, Male, Female, Middle Aged, Adult, Aged, Athletic Tape, COVID-19 complications, Wrist Fractures, Edema, Casts, Surgical, Wrist Injuries
- Abstract
Background: The adhesive elastic tape use is indicated for controlling oedema, although currently there is not the definitive evidence regarding its effectiveness. Wrist fractures are a frequent occurrence, often leading to oedema development in patients treated with forearm casts. This pilot study aims to investigate the effects of elastic tape in controlling hand oedema among patients with forearm casts for wrist fractures and the feasibility of a future randomized controlled trial., Methods: The study was conducted on adult patients with unilateral conservatively treated wrist fracture. The tape was applied to the intervention group after cast application, while the control group received the standard treatment. The circumference difference between baseline and the 7-day follow-up of both the 1st finger and the remaining 4 fingers merged together was evaluated. Ethical approval for the study has been obtained., Results: 23 participants were enrolled. The intervention group showed a higher reduction in finger circumferences compared to the control group (median difference T1-T0 No tape vs Tape: 0 cm vs -0.2 cm for the 1st finger and 0.5 cm vs -0.5 cm for the remaining 4 fingers), although the changes were not statistically significant., Conclusion: Although the number of enrolled patients was limited due to Covid-19 pandemic, the study results suggest a potential reduction in oedema after the use of adhesive elastic tape, justifying the needed of a future full-scale study. Given its low cost and ease of use, we believe that tape can be considered in clinical practice., Trial Registration: ClinicalTrials.gov Identifier: NCT04683887., Competing Interests: Declaration of competing interest Andrea Civardi is the specialist from the company producing the tape (Essity), he did contribute to the design of the study and trained nurses in the tape's application and he didn't participate in the acquisition and analysis of data. The other authors declare that they have no conflicts of interest., (Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
15. Outpatient health care statistics data warehouse--implementation.
- Author
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Zilli D
- Subjects
- Cost-Benefit Analysis, Decision Support Techniques, Humans, Ambulatory Care statistics & numerical data, Information Management economics, Mathematical Computing, Online Systems economics
- Abstract
Data warehouse implementation is assumed to be a very knowledge-demanding, expensive and long-lasting process. As such it requires senior management sponsorship, involvement of experts, a big budget and probably years of development time. Presented Outpatient Health Care Statistics Data Warehouse implementation research provides ample evidence against the infallibility of the above statements. New, inexpensive, but powerful technology, which provides outstanding platform for On-Line Analytical Processing (OLAP), has emerged recently. Presumably, it will be the basis for the estimated future growth of data warehouse market, both in the medical and in other business fields. Methods and tools for building, maintaining and exploiting data warehouses are also briefly discussed in the paper.
- Published
- 1999
16. Supercritical fluid extraction of polychlorinated biphenyls from lyophilized fish tissue.
- Author
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Bøwadt S, Johansson B, Fruekilde P, Hansen M, Zilli D, Larsen B, and de Boer J
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- Animals, Chromatography, Gas, Electrons, Food Preservation, Freeze Drying, Species Specificity, Tuna, Fishes, Polychlorinated Biphenyls analysis
- Abstract
A method for the rapid interference free analysis of polychlorinated biphenyl congeners (chlorinated biphenyls, CBs) in lyophilized fish tissue is presented. The method was developed on a lyophilized tuna muscle tissue that contained 2.8% lipid (dry mass based), and native CB concentrations in the range of 3-84 ng/g. Sample preparation was made by supercritical fluid extraction using pure CO2 as extraction fluid. Analysis by high-resolution gas chromatography-electron-capture detection analysis was carried out with on-column injection on two parallel coupled columns, a 60 m DB-17 column and a series combination of a 25 m SIL-8 column and a 25 m HT-5 column. Supercritical fluid extraction was compared with Soxhlet extraction and found to give quantitative recoveries, detection limits of 0.5-2 ng/g and standard deviations of less than 5% on average. The developed method was confirmed on nine different lyophilized fish samples which contained 6.1-26.5% lipid (dry mass based), and native CB concentrations in the range 0.8-134 ng/g.
- Published
- 1994
- Full Text
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17. The adenovirus E3 region 14.7 kDa protein, heat and sodium arsenite inhibit the TNF-induced release of arachidonic acid.
- Author
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Zilli D, Voelkel-Johnson C, Skinner T, and Laster SM
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- Adenovirus E3 Proteins genetics, Adenovirus E3 Proteins metabolism, Animals, Calcimycin pharmacology, Cell Line, Cycloheximide pharmacology, Fibroblasts drug effects, Fibroblasts metabolism, Hot Temperature, Kinetics, Mice, Mice, Inbred C3H, Recombinant Proteins pharmacology, Transfection, Adenovirus E3 Proteins pharmacology, Arachidonic Acid metabolism, Arsenic pharmacology, Arsenites, Sodium Compounds, Tumor Necrosis Factor-alpha pharmacology
- Abstract
In this report we show that the adenovirus E3 region 14.7 kDa protein, heat and sodium arsenite, which have been defined previously as inhibitors of cytolysis, inhibit the tumor necrosis factor-alpha (TNF)-induced release of 3H-arachidonic acid from cycloheximide-sensitized C3HA fibroblasts. Since the A23187-induced release of 3H-a.a. was unaffected, our results suggest that these inhibitors provide resistance to lysis by selectively interfering with the lytic response pathway. Our results also show that heat and sodium arsenite can themselves induce the release of 3H-arachidonic acid. These results raise the possibility that stressor-induced resistance to TNF results from the selective desensitization of phospholipase A2.
- Published
- 1992
- Full Text
- View/download PDF
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