7 results on '"DANIŞMAN, Betül"'
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2. Evaluating the Effects of Acute and Chronic Doxorubicin Administration on Cardiac Function Through Electrocardiographic Measurements.
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GÖKÇE, Yasin, DANIŞMAN, Betül, and ÇİÇEK, Betül
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HEART physiology , *INTRAPERITONEAL injections , *HEART rate monitoring , *DESCRIPTIVE statistics , *ELECTROCARDIOGRAPHY , *HEART conduction system , *RATS , *DOXORUBICIN , *ANIMAL experimentation - Abstract
Background: The medications used to treat cancer can lead to cardiac problems, which restricts their use. Furthermore, the method these medications are taken seems to have an impact on varied outcomes. Therefore, this study aimed to examine whether administering doxorubicin (DOX) agent acutely and chronically has distinct impacts on the electrical activity of the heart. Materials and Methods: Twenty-six male Wistar-Albino rats, weighing between 200-250 grams, were split into three groups: control group; no treatment was applied to animals (n=8), DOX acute group: a single dosage of 15.05 mg/kg of DOX was given at the end of the 3 weeks (n=8), DOX chronic group; which received an intraperitoneal (i.p.) 2.15 mg/kg DOX for 3 weeks, 7 doses in total (n=10). At the end of the experimental period, electrocardiogram (ECG) measurements were taken for all animals and evaluated. Results: ECG data showed that heart rate (HR), P wave amplitude, and P duration did not differ between the acute and control groups but did statistically significantly declined in the chronic group. In both DOX groups, PR interval remained unchanged compared to the control. Also, RR interval increased significantly in the chronic group while it remained unchanged in the acute DOX dose group. The QRS duration was found to have considerably increased in both DOX groups. Furthermore, it was found that both DOX groups had a considerable increase in the QT interval, although the chronic group's increase was more noticeable. Conclusions: In conclusion, it is thought that the ways in which these medications are administered may result in significant variations in heart function. Acute DOX treatment appears to be less harmful than chronic exposure, as evidenced by its lack of adverse effects, particularly on P wave amplitude (a measure of atrial contraction) and P wave duration (the length of the contraction). However, more research is required to validate these findings. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Protective Effects of Resveratrol Carbon Dots Against 6-OHDA-Induced Neurotoxicity in SH-SY5Y Cells.
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ÇİÇEK, Betül and DANIŞMAN, Betül
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DRUG therapy for Parkinson's disease , *NEUROTOXICOLOGY , *CYTOKINES , *IN vitro studies , *SYNDROMES , *NEURONS , *CARBON , *ANTIOXIDANTS , *APOPTOSIS , *OXIDIZING agents , *INTERLEUKIN-1 , *RESVERATROL , *OXIDATIVE stress , *DOPAMINE , *GENE expression , *PARKINSON'S disease , *TUMOR necrosis factors , *MESSENGER RNA , *DESCRIPTIVE statistics , *CELL lines , *NANOPARTICLES , *CASPASES - Abstract
Background: We aimed to investigate the ability of resveratrol carbon dots (RES C-Dots) to protect SHSY5Y cells from oxido-inflammatory stress and apoptosis caused by 6-hydroxydopamine (6-OHDA). Materials and Methods: In vitro PD model was generated in SH-SY5Y cells by administering of 200 µM 6- OHDA for 24 hours. Different concentrations of RES C-Dots (12.5, 25, and 50 µg/mL) were applied to the cells 30 minutes before administration of 6-OHDA. Results: We observed that application of RES C-Dots prevented cell death induced by 6-OHDA and maintained cell viability. As expected, RES C-Dots prevented oxidative damage induced by 6-OHDA - by strengthening the total amount of antioxidants and lowering the total amount of oxidants in SH-SY5Y cells. Similarly, RES C-Dots markedly alleviated the secretion of inflammatory factors (TNF-α and IL-1β) promoted by 6-OHDA. Furthermore, RES C-Dots prevented apoptosis induced by 6-OHDA by suppressing caspase-3 mRNA expression level. Conclusions: RES C-Dots rescued SH-SY5Y cells from 6-OHDA- induced damage by modulating the oxidoinflammatory and apoptotic response. This report indicates enounces that RES- synthesised C-Dots may have promising curative potential for PD. [ABSTRACT FROM AUTHOR]
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- 2023
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4. Effect of Postnatal Thiamine Deficiency on Central Auditory Processing During Adulthood
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KANTAR, Deniz, primary, DANIŞMAN, Betül, additional, and SONBAY YILMAZ, Nevreste Didem, additional
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- 2022
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5. Effects of thiamine deficiency exposed during prenatal and lactation on behaviour, learning and memory in adulthood
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DANIŞMAN, Betül, primary, AKÇAY, Güven, additional, and KANTAR GÖK, Deniz, additional
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- 2022
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6. Prenatal ve emzirme döneminde maruz kalınan tiamin eksikliğinin yetişkinlikte davranış, öğrenme ve hafızaya etkileri.
- Author
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DANIŞMAN, Betül, AKÇAY, Güven, and KANTAR GÖK, Deniz
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VITAMIN B deficiency , *MAZE tests , *ESSENTIAL nutrients , *VITAMIN B1 , *MALNUTRITION , *MEMORY disorders - Abstract
Objective: Thiamine (vitamin B1) is an essential nutrient that acts as a cofactor for many enzymes, especially in the mitochondria. Some thiamine-linked enzymes participate in energy metabolism and the biosynthesis of nucleic acids, while others act as part of the antioxidant mechanism. As the brain is heavily dependent on mitochondrial ATP production, it is highly vulnerable to thiamine deficiency (TD). This effect is more pronounced in prenatal and childhood periods when rapid growth occurs. In this study, behavioral changes in adulthood of TD-induced rats during prenatal and lactation periods were investigated. Methods: In the study, rats were divided into two groups as the group whose mothers were fed a normal diet (NN) and the mothers were fed with thiamine deficient diet (TN) during prenatal and lactation periods. Open Field test, Elevated Plus Maze test and New Object Recognition tests were applied to rats in adulthood. Results: In the thiamine deficient TN group, it was observed that the number of frames entered in the open field test and the rate of time spent in the outer quadrant increased. In addition, in the elevated plus maze test, the ratio of time spent in the open arm in the TN group was decreased. In the new object recognition test, it was determined that the discrimination index was decreased in the TN group. Conclusion: In our study, it was observed that the effects of TD during prenatal and lactation periods can continue in the long term and cause behavioral, learning and memory deficits in the later ages. [ABSTRACT FROM AUTHOR]
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- 2022
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7. Spinodal instabilities in symmetric nuclear matter within a density-dependent relativistic mean-field approach
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Danişman, Betül, Yılmaz, Osman, Ayık, Şakir, and Diğer
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Fizik ve Fizik Mühendisliği ,Physics and Physics Engineering - Abstract
Sonsuz simetrik nükleer maddedeki spinodal kararsızlıklar, yoğunluğa bağlı relativistikstokastik ortalama alan modeli kullanılarak yarı-klasik yaklaşımda çalışıldı.Lagrange yoğunluğu için iki parametri seti olarak DDME1 ve TW setlerikullanıldı. Yoğunluk dalgalanmalarının ilk anlarındaki büyüme QHD'yıesas alan relativistik Vlasov denklemi kullanılarak incelendi ve yoğunluk korelasyonfonksiyonlarının ilk anlarında oluşan yoğunlaşmaların boyutları tartışıldı.Sistemin en kararsız davranışının düşük sıcaklıklarda ve doygunluk değerininaltındada ?b = ?0/4 yoğunluğu etrafında olması beklenir. Bu nedenle, sonuçlarT=1 MeV ve T=5 MeV sıcaklıklarında ve sistemin kararsız olduğu iki farklıbaşlangıç baryon yoğunlukları olan ?b = 0.2?0 ve ?b = 0.4?0 için incelendi.Yoğunluğa bağlı olarakçalışılan modelde elde edilen sonuçlar, relativistik linearolmayan ve Skyrme-tipi relativisitik olmayan modeller kullanılarak yapılançalışmalarda elde edilen hesaplarla karşılaştırıldı. Elde edilen sonuçların birbirleriyleuyumlu oldukları gözlendi. Bulunan benzer sonuçlar, niceliklerin fiziğininmodelden bağımsız olduğunu gösterdi. En kararsız modların yarı-dalgaboylarınınyarısı ve korelasyon fonksiyonlarının maximum genişliğinin yarısına karşı gelenmesafelerin, yoğunlaşmaların boyutları olarak elde edildi. Ayrıca, spinodalayrışmanın ilk evresindeki yoğunlaşan damlacıkların ortalama hızları, akımyoğunluğu korelasyon fonksiyonları kullanılarak elde edildi. The nuclear matter liquid-gas phase transition is expected to be a signal of nuclearspinodal instabilities as a result of density fluctuations. Nuclear spinodalinstabilities in symmetric nuclear matter are studied within a stochastic relativisticdensity-dependent model in semi-classical approximation. We use twoparameterization for the Lagrange density, DDME1 and TW sets. The earlygrowth of density fluctuations is investigated by employing relativistic Vlasovequation based on QHD and discussed the cluster size of the condensationsfrom the early growth of density correlation functions. Expectations are thathot nuclear matter behaves unstable around ?b ? ?0/4 (below the saturationdensity) and at low temperatures. We therefore present our results at low temperatureT=1 MeV and at higher temperature T=5 MeV, and also at a lowerinitial baryon density ?b = 0.2 ?0 and a higher value ?b = 0.4 ?0 where unstablebehavior is within them.Calculations in density-dependent model are compared with the other calculationsobtained in a relativistic non-linear model and in a Skyrme type nonivrelativistic model. Our results are consistent with them. Qualitatively similarresults show that the physics of the quantities are model-independent. The sizeof clusterization is estimated in two ways, by using half-wavelength of the mostunstable mode and from the width of correlation function at half maximum. Furthermore,the average speed of condensing fragments during the initial phase ofspinodal decomposition are determined by using the current density correlationfunctions. 92
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- 2011
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