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5 results on '"Dalcourt, Tatyana"'

1. Multiplatform molecular profiling uncovers two subgroups of malignant peripheral nerve sheath tumors with distinct therapeutic vulnerabilities

Author

Suppiah, Suganth, Mansouri, Sheila, Mamatjan, Yasin, Liu, Jeffrey C., Bhunia, Minu M., Patil, Vikas, Rath, Prisni, Mehani, Bharati, Heir, Pardeep, Bunda, Severa, Velez-Reyes, German L., Singh, Olivia, Ijad, Nazanin, Pirouzmand, Neda, Dalcourt, Tatyana, Meng, Ying, Karimi, Shirin, Wei, Qingxia, Nassiri, Farshad, Pugh, Trevor J., Bader, Gary D., Aldape, Kenneth D., Largaespada, David A., and Zadeh, Gelareh

Published
2023
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3. Loss of H3K27me3 in meningiomas

Author

Nassiri, Farshad, Wang, Justin Z, Dimeco, Francesco, Yip, Stephen, Gao, Andrew, Aldape, Kenneth D, Zadeh, Gelareh, Aldape, Kenneth, Au, Karolyn, Barnholtz-Sloan, Jill, Behling, Felix, Singh, Olivia, Brastianos, Priscilla, Butowski, Nicholas, Brodie, Chaya, Cohen-Gadol, Aaron, Couce, Marta, Drummond, Kate, Dunn, Ian, Galanis, Eva, Karimi, Shirin, Galldiks, Norbert, Giannini, Caterina, Goldbrunner, Roland, Hanemann, Oliver, Herold-Mende, Christel, Horbinski, Craig, Huang, Raymond, Javadpour, Mohsen, Jenkinson, Michael, Jungk, Christine, Dalcourt, Tatyana, Kaufmann, Timothy, Krischek, Boris, Kurz, Sylvia, Lachance, Daniel, Lafougere, Christian, Lamszus, Katrin, Lee, Ian, Malta, Tathiana, Makarenko, Serge, Mawrin, Christian, Ijad, Nazanin, McDermott, Michael, Millward, Christopher, Moliterno-Gunel, Jennifer, Morokoff, Andrew, Ng, H. K., Noushmehr, Houtan, Perry, Arie, Poisson, Laila, Pollo, Bianco, Pirouzmand, Neda, Ragunathan, Aditya, Raleigh, David, Renovanz, Mirjam, Ricklefs, Franz, Sahm, Felix, Saladino, Andrea, Santacroce, Antonio, Santarius, Thomas, Schichor, Christian, Schimdt, Nils, Ng, Ho-Keung, Schittenhelm, Jens, Selman, Warren, Shih, Helen, Snyder, Jim, Snuderl, Matja, Sloan, Andrew, Suppiah, Suganth, Sulman, Erik, Tabatabai, Ghazaleh, Tatagiba, Marcos, Timmer, Marcos, Tonn, Joerg-Christian, Von Deimling, Andreas, Vogelbaum, Michael, Walbert, Tobias, Wang, Justin, Wen, Patrick, Westphal, Manfred, Pollo, Bianca, and Bi, Wenya

Subjects
Oncology, Cancer Research, medicine.medical_specialty, macromolecular substances, Meningioma, Histones, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Meningeal Neoplasms, Medicine, Humans, Meningeal Neoplasm, ddc:610, 030304 developmental biology, 0303 health sciences, REPRODUTIBILIDADE DE RESULTADOS, business.industry, Proportional hazards model, Editorials, Cancer, Reproducibility of Results, medicine.disease, Prognosis, Staining, 030220 oncology & carcinogenesis, Cohort, Immunohistochemistry, Neurology (clinical), Neoplasm Recurrence, Local, business, Who classification
Abstract

Background There is a critical need for objective and reliable biomarkers of outcome in meningiomas beyond WHO classification. Loss of H3K27me3 has been reported as a prognostically unfavorable alteration in meningiomas. We sought to independently evaluate the reproducibility and prognostic value of H3K27me3 loss by immunohistochemistry (IHC) in a multicenter study. Methods IHC staining for H3K27me3 and analyses of whole slides from 181 meningiomas across three centers was performed. Staining was analyzed by dichotomization into loss and retained immunoreactivity, and using a 3-tiered scoring system in 151 cases with clear staining. Associations of grouping with outcome were performed using Kaplan-Meier survival estimates. Results A total of 21 of 151 tumors (13.9%) demonstrated complete loss of H3K27me3 staining in tumor with retained endothelial staining. Overall, loss of H3K27me3 portended a worse outcome with shorter times to recurrence in our cohort, particularly for WHO grade 2 tumors which were enriched in our study. There were no differences in recurrence-free survival (RFS) for WHO grade 3 patients with retained vs loss of H3K27me3. Scoring by a 3-tiered system did not add further insights into the prognostic value of this H3K27me3 loss. Overall, loss of H3K27me3 was not independently associated with RFS after controlling for WHO grade, extent of resection, sex, age, and recurrence status of tumor on multivariable Cox regression analysis. Conclusions Loss of H3K27me3 identifies a subset of WHO grade 2 and possibly WHO grade 1 meningiomas with increased recurrence risk. Pooled analyses of a larger cohort of samples with standardized reporting of clinical definitions and staining patterns are warranted.

Published
2021

5. Loss of H3K27me3 in meningiomas.

Author

Nassiri F, Wang JZ, Singh O, Karimi S, Dalcourt T, Ijad N, Pirouzmand N, Ng HK, Saladino A, Pollo B, Dimeco F, Yip S, Gao A, Aldape KD, and Zadeh G

Subjects
Histones, Humans, Neoplasm Recurrence, Local, Prognosis, Reproducibility of Results, Meningeal Neoplasms, Meningioma
Abstract

Background: There is a critical need for objective and reliable biomarkers of outcome in meningiomas beyond WHO classification. Loss of H3K27me3 has been reported as a prognostically unfavorable alteration in meningiomas. We sought to independently evaluate the reproducibility and prognostic value of H3K27me3 loss by immunohistochemistry (IHC) in a multicenter study., Methods: IHC staining for H3K27me3 and analyses of whole slides from 181 meningiomas across three centers was performed. Staining was analyzed by dichotomization into loss and retained immunoreactivity, and using a 3-tiered scoring system in 151 cases with clear staining. Associations of grouping with outcome were performed using Kaplan-Meier survival estimates., Results: A total of 21 of 151 tumors (13.9%) demonstrated complete loss of H3K27me3 staining in tumor with retained endothelial staining. Overall, loss of H3K27me3 portended a worse outcome with shorter times to recurrence in our cohort, particularly for WHO grade 2 tumors which were enriched in our study. There were no differences in recurrence-free survival (RFS) for WHO grade 3 patients with retained vs loss of H3K27me3. Scoring by a 3-tiered system did not add further insights into the prognostic value of this H3K27me3 loss. Overall, loss of H3K27me3 was not independently associated with RFS after controlling for WHO grade, extent of resection, sex, age, and recurrence status of tumor on multivariable Cox regression analysis., Conclusions: Loss of H3K27me3 identifies a subset of WHO grade 2 and possibly WHO grade 1 meningiomas with increased recurrence risk. Pooled analyses of a larger cohort of samples with standardized reporting of clinical definitions and staining patterns are warranted., (© The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Published
2021
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