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13 results on '"Davis, Chadwick T."'

1. Neuroinflammatory disease disrupts the blood-CNS barrier via crosstalk between proinflammatory and endothelial-to-mesenchymal-transition signaling

Author

Sun, Zhonglou, primary, Zhao, Helong, additional, Fang, Daniel, additional, Davis, Chadwick T., additional, Shi, Dallas S., additional, Lei, Kachon, additional, Rich, Bianca E., additional, Winter, Jacob M., additional, Guo, Li, additional, Sorensen, Lise K., additional, Pryor, Robert J., additional, Zhu, Nina, additional, Lu, Samuel, additional, Dickey, Laura L., additional, Doty, Daniel J., additional, Tong, Zongzhong, additional, Thomas, Kirk R., additional, Mueller, Alan L., additional, Grossmann, Allie H., additional, Zhang, Baowei, additional, Lane, Thomas E., additional, Fujinami, Robert S., additional, Odelberg, Shannon J., additional, and Zhu, Weiquan, additional

Published
2022
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4. Interleukin receptor activates a MYD88-ARNO-ARF6 cascade to disrupt vascular stability

Author

Zhu, Weiquan, London, Nyall R., Gibson, Christopher C., Davis, Chadwick T., Tong, Zongzhong, Sorensen, Lise K., Shi, Dallas S., Guo, Jinping, Smith, Matthew C.P., Grossmann, Allie H., Thomas, Kirk R., and Li, Dean Y.

Subjects
Inflammation -- Mediators, Immune response -- Observations, Cellular signal transduction -- Research, Interleukins -- Testing, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The innate immune response is essential for combating infectious disease. Macrophages and other cells respond to infection by releasing cytokines, such as interleukin-1β (IL-1β), which in turn activate a well-described, [...]

Published
2012
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5. Crohn’s Disease and Genetic Hitchhiking at IBD5

Author

Huff, Chad D., Witherspoon, David J., Zhang, Yuhua, Gatenbee, Chandler, Denson, Lee A., Kugathasan, Subra, Hakonarson, Hakon, Whiting, April, Davis, Chadwick T., Wu, Wilfred, Xing, Jinchuan, Watkins, W. Scott, Bamshad, Michael J., Bradfield, Jonathan P., Bulayeva, Kazima, Simonson, Tatum S., Jorde, Lynn B., and Guthery, Stephen L.

Published
2012
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6. Functional immune mapping with deep-learning enabled phenomics applied to immunomodulatory and COVID-19 drug discovery

Author

Cuccarese, Michael F., primary, Earnshaw, Berton A., additional, Heiser, Katie, additional, Fogelson, Ben, additional, Davis, Chadwick T., additional, McLean, Peter F., additional, Gordon, Hannah B., additional, Skelly, Kathleen-Rose, additional, Weathersby, Fiona L., additional, Rodic, Vlad, additional, Quigley, Ian K., additional, Pastuzyn, Elissa D., additional, Mendivil, Brandon M., additional, Lazar, Nathan H., additional, Brooks, Carl A., additional, Carpenter, Joseph, additional, Probst, Brandon L., additional, Jacobson, Pamela, additional, Glazier, Seth W., additional, Ford, Jes, additional, Jensen, James D., additional, Campbell, Nicholas D., additional, Statnick, Michael A., additional, Low, Adeline S., additional, Thomas, Kirk R., additional, Carpenter, Anne E., additional, Hegde, Sharath S., additional, Alfa, Ronald W., additional, Victors, Mason L., additional, Haque, Imran S., additional, Chong, Yolanda T., additional, and Gibson, Christopher C., additional

Published
2020
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7. Identification of potential treatments for COVID-19 through artificial intelligence-enabled phenomic analysis of human cells infected with SARS-CoV-2

Author

Heiser, Katie, primary, McLean, Peter F., additional, Davis, Chadwick T., additional, Fogelson, Ben, additional, Gordon, Hannah B., additional, Jacobson, Pamela, additional, Hurst, Brett, additional, Miller, Ben, additional, Alfa, Ronald W., additional, Earnshaw, Berton A., additional, Victors, Mason L., additional, Chong, Yolanda T., additional, Haque, Imran S., additional, Low, Adeline S., additional, and Gibson, Christopher C., additional

Published
2020
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8. Cell Painting, an image-based assay for morphological profiling

Author

Bray, Mark-Anthony, primary, Singh, Shantanu, additional, Han, Han, additional, Davis, Chadwick T., additional, Borgeson, Blake, additional, Hartland, Cathy, additional, Kost-Alimova, Maria, additional, Gustafsdottir, Sigrun M., additional, Gibson, Christopher C., additional, and Carpenter, Anne E., additional

Published
2016
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10. Strategy for Identifying Repurposed Drugs for the Treatment of Cerebral Cavernous Malformation

Author

Gibson, Christopher C., primary, Zhu, Weiquan, additional, Davis, Chadwick T., additional, Bowman-Kirigin, Jay A., additional, Chan, Aubrey C., additional, Ling, Jing, additional, Walker, Ashley E., additional, Goitre, Luca, additional, Delle Monache, Simona, additional, Retta, Saverio Francesco, additional, Shiu, Yan-Ting E., additional, Grossmann, Allie H., additional, Thomas, Kirk R., additional, Donato, Anthony J., additional, Lesniewski, Lisa A., additional, Whitehead, Kevin J., additional, and Li, Dean Y., additional

Published
2015
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13. Purification and characterization of Yersinia enterocolitica and Yersinia pestis LcrV–cholera toxin A2/B chimeras

Author

Tinker, Juliette K., Davis, Chadwick T., and Arlian, Britni M.

Subjects
*CHOLERA toxin, *YERSINIA pestis, *YERSINIA enterocolitica, *PROTEIN fractionation, *GENE expression, *MOSAICISM, *BACTERIAL antigens, *PROTEIN analysis
Abstract

Abstract: Yersinia pestis is a virulent human pathogen and potential biological weapon. Despite a long history of research on this organism, there is no licensed vaccine to protect against pneumonic forms of Y. pestis disease. In the present study, plasmids were constructed to express cholera toxin A2/B chimeric molecules containing the LcrV protective antigen from Yersinia enterocolitica and Y. pestis. These chimeras were expressed and purified to high yields from the supernatant of transformed Escherichia coli. Western and GM1 ELISA assays were used to characterize the composition, receptor-binding and relative stability of the LcrV–CTA2/B chimera in comparison to cholera toxin. In addition, we investigated the ability of the Y. pestis LcrV–CTA2/B chimera to bind to and internalize into cultured epithelial cells and macrophages by confocal microscopy. These studies indicate that the uptake and trafficking of the LcrV antigen from the chimera is comparable to the trafficking of native toxin. Together these findings report that stable, receptor-binding, non-toxic LcrV–cholera toxin A2/B chimeras can be expressed at high levels in E. coli and purified from the supernatant. In addition, the internalization of antigen in vitro reported here supports the development of these molecules as novel mucosal vaccine candidates. [ABSTRACT FROM AUTHOR]

Published
2010
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