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Background: Frailty is a dynamic age-related condition of increased vulnerability characterized by declines across multiple physiologic systems and associated with an increased risk of death. We compared the predictive accuracy for one-month and one-year all-cause mortality of four frailty instruments in a large population of hospitalized older patients in a prospective multicentre cohort study. Methods and Findings: On 2033 hospitalized patients aged $65 years from twenty Italian geriatric units, we calculated the frailty indexes derived from the Study of Osteoporotic Fractures (FI-SOF), based on the cumulative deficits model (FI-CD), based on a comprehensive geriatric assessment (FI-CGA), and the Multidimensional Prognostic Index (MPI). The overall mortality rates were 8.6% after one-month and 24.9% after one-year follow-up. All frailty instruments were significantly associated with one-month and one-year all-cause mortality. The areas under the receiver operating characteristic (ROC) curves estimated from age- and sex-adjusted logistic regression models, accounting for clustering due to centre effect, showed that the MPI had a significant higher discriminatory accuracy than FI-SOF, FI-CD, and FI-CGA after one month (areas under the ROC curves: FI-SOF = 0.685 vs. FI-CD = 0.738 vs. FI-CGA = 0.724 vs. MPI = 0.765, p,0.0001) and one year of followup (areas under the ROC curves: FI-SOF = 0.694 vs. FI-CD = 0.729 vs. FI-CGA = 0.727 vs. MPI = 0.750, p,0.0001). The MPI showed a significant higher discriminatory power for predicting one-year mortality also in hospitalized older patients without functional limitations, without cognitive impairment, malnourished, with increased comorbidity, and with a high number of drugs. Conclusions: All frailty instruments were significantly associated with short- and long-term all-cause mortality, but MPI demonstrated a significant higher predictive power than other frailty instruments in hospitalized older patients.

L'esposizione umana ai PFC avviene principalmente attraverso la dieta ed in particolar modo il pesce è risultato tra i prodotti alimentari più inquinati. Il perfluorottano sulfonato (PFOS) e l’acido perfluorottanoico (PFOA) sono i composti più importanti e studiati. Lo scopo del presente lavoro è stato quello di effettuare un monitoraggio preliminare sulla presenza di queste due molecole in 50 campioni di muscolo di branzini, di cui 30 allevati e 20 pescati, prelevati in diverse località italiane del mar Mediterraneo. Il metodo utilizzato prevede un’estrazione con solvente seguita da due passaggi di purificazione: uno con sali ed uno con fase solida dispersiva. L’estratto è stato poi analizzato mediante un sistema UPLC-MS/MS. I dati mostrano ampia contaminazione di questa specie ed evidenziano una netta prevalenza di PFC nei branzini pescati (PFOS da 112,4 ng/L a >2000 ng/L e PFOA da 3,3 ng/L a 487,0 ng/L) rispetto a quelli allevati (PFOS da 11,1 ng/L a 104,5 ng/L e PFOA da