279 results on '"Diseño factorial"'
Search Results
2. Optimización rápida de desinfectantes asistida por análisis de imagen fotográfico y diseño de experimentos.
- Author
-
Valdez-Salas, Benjamín, Salvador-Carlos, Jorge, Beltrán-Partida, Ernesto, Curiel-Álvarez, Mario, Cheng, Nelson, and Valdez-Salas, Ernesto
- Subjects
COVID-19 pandemic ,PHOTOGRAPHS ,FACTORIAL experiment designs ,IMAGE analysis ,COLLOIDAL stability - Abstract
Copyright of DYNA - Ingeniería e Industria is the property of Publicaciones Dyna SL and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2024
- Full Text
- View/download PDF
3. Diseño y validación de la Escala breve de Actitudes sobre la Didáctica de la Expresión Plástica (EADEP)
- Author
-
María Pilar Aparicio Flores, Rosa Pilar Esteve Faubel, Aitana Fernández-Sogorb, and Carolina Gonzálvez
- Subjects
Educación artística ,educación plástica ,validación ,diseño factorial ,cuestionario ,Education ,Education (General) ,L7-991 - Abstract
INTRODUCCIÓN. La educación artística influye beneficiosamente en el desarrollo integral del ser humano. Sin embargo, existe una carencia por lo que respecta a su investigación, como también lo es respecto al conocimiento de estas ventajas. Por ese motivo, es de especial relevancia examinar la actitud de los futuros maestros sobre el arte, o de forma más concreta, en cuanto a su didáctica. No obstante, hasta el momento no se han encontrado escalas que evalúen, desde una metodología cuantitativa, las actitudes con respecto a la Didáctica de la Expresión Plástica. Por ese motivo, este trabajo tuvo como objetivo diseñar y validar la Escala breve de Actitudes sobre la Didáctica de la Expresión Plástica (EADEP) y observar la invarianza entre sexos. MÉTODO. Para ello, se partió de una muestra de 190 futuros docentes (Medad = 20.05; DT = 3.67) para un primer estudio y 790 (Medad = 19.88; DT= 4.03) para un segundo. RESULTADOS. El primero de ellos arrojó un factor para la EADEP con adecuadas propiedades psicométricas. El segundo de ellos indicó un buen ajuste de los datos para la estructura unidimensional de la EADEP, manteniéndose invariante en función del sexo. CONCLUSIÓN. Se ofrece, por tanto, un instrumento de medida válido y fiable para la actitud hacia la Didáctica de la Expresión Plástica y se reflexiona sobre la necesidad de aumentar los estudios en este campo.
- Published
- 2024
- Full Text
- View/download PDF
4. Metodologías estadísticas utilizadas en la experimentación con materiales poliméricos: una revisión bibliográfica.
- Author
-
Aguirre Poblador, José Felipe, Baena Peréz, Libia María, and Correa Álvarez, Cristian David
- Subjects
- *
EXPERIMENTAL design , *FACTORIAL experiment designs , *RESEARCH personnel , *RESEARCH methodology - Abstract
In this article, a bibliographical review of some methodologies of design of experiments is carried out, focusing on its function and relevance within the experiments, where the importance of the designs of experiments within the investigation is highlighted using examples of the strategies and designs of experiments. In the first place, a review was carried out that would allow the introduction of the concept of design of experiments, how it was conceived, its principles and its relationship with the investigation, including the main elements of which designs of experiments are composed, and some assumptions to be considered at the time of apply an experimental design in research are included. In addition, different methodologies used by some authors in experiments are shown, what they are and a basic notion of the different methodologies used in the research, focusing on the differences between each one of them and why to use them according to the need of the experiment, then from this, different examples of the different experimental design methodologies used in research articles focused on polymeric materials were carried out, in these examples the different variables of the experiment were stood up, what was the purpose of the investigation and why they opted for the design of experiments they mention. Finally, after carrying out the bibliographical review, it was found that in most of the experimental design applied to the field of experimentation, it allows optimizing the resources without the need to make many attempts. In fact, depending on the type of experiment, it will be feasible to choose a design that is accommodate the needs of the researchers, according to the objectives set in the experiment. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
5. Experimental investigation of High-Performance Concrete subjected to high temperatures.
- Author
-
Kessal, O., Bennia, A., Hidalgo, D. Bravo, Belkadi, A. Abderraouf, and Khouadjia, M. Kamel
- Subjects
- *
HIGH temperatures , *MECHANICAL behavior of materials , *COMPOSITE materials , *REINFORCED concrete , *COMPRESSIVE strength - Abstract
In this paper, we present an experimental study and statistical modeling of High-Performance Concrete subjected to high temperatures. The main objective of this study is to examine the effect of concrete age subjected to high temperature cycles (ranging from 20 °C to 1000 °C) on the physical and the mechanical properties of (HPC). The compressive strength, flexural strength, dynamic modulus and the physical characteristics were evaluated based on the mass loss and ultrasonic pulse velocity. The experiments have been performed at different age 90 and 210days. The analysis of the results shows that increasing temperature decreases the mechanical properties of the concrete especially after 90 days. The factorial design and analysis of variance (ANOVA) were used to establish the influence of experimental parameters on the HPC. Based on several criteria, mathematical models can be used to predict HPC properties under high temperature. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
6. Definición de dosis de nitrógeno, fósforo y potasio para una máxima producción del maíz híbrido Advanta 9313 mediante el diseño central compuesto
- Author
-
Freddy Carlos Gavilánez-Luna and María José Gómez-Vargas
- Subjects
diseño factorial ,fertilización ,manejo del cultivo ,rendimiento de cultivos ,zea mays ,Agriculture ,Agriculture (General) ,S1-972 ,Animal culture ,SF1-1100 - Abstract
La falta de conocimiento en cuanto a los intervalos de macronutrientes como nitrógeno (N), fósforo (P) y potasio (K) aplicados al maíz es una de las falencias que no permiten aprovechar la potencialidad de semillas certificadas, lo cual se complica aún más cuando no se utilizan los diseños experimentales adecuados para establecer dichos intervalos. Ante esta situación se desarrolló esteensayo con un arreglo factorial incompleto de segundo orden denominado diseño central compuesto (DCC), con el fin de identificar intervalos de macronutrientes para una mayor producción de maíz. Se empleó una distribución de bloques completos al azar, en los cuales se probaron 15 formulaciones (tratamientos) de N-P-K con tres repeticiones de cada una y como variable de respuesta se evaluó el rendimiento de grano seco. Los datos se valoraron mediante análisis de varianza para detectar efectos lineales y cuadráticos, se obtuvieron las respectivas superficies de respuesta y gráficas de contorno y se ajustó un modelo de segundo orden. Se estableció que los rendimientos de maíz más altos, ubicados entre 10 y 11 t/ha, se obtienen cuando se aplican entre 110 a 140 kg/ha de nitrógeno, de 50 a 70 kg/ha de fósforo y de 100 a 140 kg/ha de potasio. Además, se corrobora la bondad del DCC cuando se conocen los límites de operatividad experimental de los factores de estudio.
- Published
- 2022
- Full Text
- View/download PDF
7. Diseño y validación de la Escala breve de Actitudes sobre la Didáctica de la Expresión Plástica (EADEP)
- Author
-
Universidad de Alicante. Departamento de Didáctica General y Didácticas Específicas, Universidad de Alicante. Departamento de Psicología Evolutiva y Didáctica, Aparicio-Flores, María del Pilar, Esteve-Faubel, Rosa Pilar, Fernández-Sogorb, Aitana, Gonzálvez, Carolina, Universidad de Alicante. Departamento de Didáctica General y Didácticas Específicas, Universidad de Alicante. Departamento de Psicología Evolutiva y Didáctica, Aparicio-Flores, María del Pilar, Esteve-Faubel, Rosa Pilar, Fernández-Sogorb, Aitana, and Gonzálvez, Carolina
- Abstract
INTRODUCCIÓN. La educación artística influye beneficiosamente en el desarrollo integral del ser humano. Sin embargo, existe una carencia por lo que respecta a su investigación, como también lo es respecto al conocimiento de estas ventajas. Por ese motivo, es de especial relevancia examinar la actitud de los futuros maestros sobre el arte, o de forma más concreta, en cuanto a su didáctica. No obstante, hasta el momento no se han encontrado escalas que evalúen, desde una metodología cuantitativa, las actitudes con respecto a la Didáctica de la Expresión Plástica. Por ese motivo, este trabajo tuvo como objetivo diseñar y validar la Escala breve de Actitudes sobre la Didáctica de la Expresión Plástica (EADEP) y observar la invarianza entre sexos. MÉTODO. Para ello, se partió de una muestra de 190 futuros docentes (Medad = 20.05; DT = 3.67) para un primer estudio y 790 (Medad = 19.88; DT= 4.03) para un segundo. RESULTADOS. El primero de ellos arrojó un factor para la EADEP con adecuadas propiedades psicométricas. El segundo de ellos indicó un buen ajuste de los datos para la estructura unidimensional de la EADEP, manteniéndose invariante en función del sexo. CONCLUSIÓN. Se ofrece, por tanto, un instrumento de medida válido y fiable para la actitud hacia la Didáctica de la Expresión Plástica y se reflexiona sobre la necesidad de aumentar los estudios en este campo., INTRODUCTION. Artistic education has a beneficial influence on the integral development of the human being. However, there is a gap in their research, as well as in their knowledge of these advantages. For this reason, it is especially relevant to examine the attitude of future teachers about art, or more specifically, in terms of its didactics. However, so far no scales have been found that assess, from a quantitative methodology, attitudes regarding the Didactics of Plastic Expression. For this reason, this work aimed to design and validate Brief Scale of Attitudes on the Didactics of Plastic Expression (EADEP) and observe the invariance between sexes. METHOD. To do this, a sample of 190 future teachers (Mage= 20.05; SD= 3.67) was used for a first study and 790 (Mage= 19.88; SD= 4.03) for a second. RESULTS. The first of these yielded a factor for EADEP with adequate psychometric properties. The second one indicated a good fit of the data for the unifying structure of EADEP, remaining invariant according to gender. CONCLUSION. Therefore, it offers a valid and reliable measurement instrument for the attitude towards Didactics of Plastic Expression and reflects on the need to increase studies in this field.
- Published
- 2024
8. Design and validation of the Brief Scale of Attitudes on the Didactics of Plastic Expression (SADPE)
- Author
-
Aparicio Flores, María Pilar, Esteve Faubel, Rosa Pilar, Fernández-Sogorb, Aitana, Gonzálvez, Carolina, Aparicio Flores, María Pilar, Esteve Faubel, Rosa Pilar, Fernández-Sogorb, Aitana, and Gonzálvez, Carolina
- Abstract
INTRODUCTION. Artistic education has a beneficial influence on the integral development of the human being. However, there is a gap in their research, as well as in their knowledge of these advantages. For this reason, it is especially relevant to examine the attitude of future teachers about art, or more specifically, in terms of its didactics. However, so far no scales have been found that assess, from a quantitative methodology, attitudes regarding the Didactics of Plastic Expression. For this reason, this work aimed to design and validate Brief Scale of Attitudes on the Didactics of Plastic Expression (EADEP) and observe the invariance between sexes. METHOD. To do this, a sample of 190 future teachers (Mage= 20.05; SD= 3.67) was used for a first study and 790 (Mage= 19.88; SD= 4.03) for a second. RESULTS. The first of these yielded a factor for EADEP with adequate psychometric properties. The second one indicated a good fit of the data for the unifying structure of EADEP, remaining invariant according to gender. CONCLUSION. Therefore, it offers a valid and reliable measurement instrument for the attitude towards Didactics of Plastic Expression and reflects on the need to increase studies in this field., INTRODUCCIÓN. La educación artística influye beneficiosamente en el desarrollo integral del ser humano. Sin embargo, existe una carencia por lo que respecta a su investigación, como también lo es respecto al conocimiento de estas ventajas. Por ese motivo, es de especial relevancia examinar la actitud de los futuros maestros sobre el arte, o de forma más concreta, en cuanto a su didáctica. No obstante, hasta el momento no se han encontrado escalas que evalúen, desde una metodología cuantitativa, las actitudes con respecto a la Didáctica de la Expresión Plástica. Por ese motivo, este trabajo tuvo como objetivo diseñar y validar la Escala breve de Actitudes sobre la Didáctica de la Expresión Plástica (EADEP) y observar la invarianza entre sexos. MÉTODO. Para ello, se partió de una muestra de 190 futuros docentes (Medad = 20.05; DT = 3.67) para un primer estudio y 790 (Medad = 19.88; DT= 4.03) para un segundo. RESULTADOS. El primero de ellos arrojó un factor para la EADEP con adecuadas propiedades psicométricas. El segundo de ellos indicó un buen ajuste de los datos para la estructura unidimensional de la EADEP, manteniéndose invariante en función del sexo. CONCLUSIÓN. Se ofrece, por tanto, un instrumento de medida válido y fiable para la actitud hacia la Didáctica de la Expresión Plástica y se reflexiona sobre la necesidad de aumentar los estudios en este campo.
- Published
- 2024
9. Optimizing conditions for the development process of the sponge liquid bread mold through a factorial design
- Author
-
Quintero Gil, Claudia Marcela, Rueda Quijano, Helio, Quintero Gil, Claudia Marcela, and Rueda Quijano, Helio
- Abstract
The bread in its many forms is one of the oldest and most widely food consumed by humanity, its appearance is not known for sure, but it is presumed that he was in the Middle East, where he began to cultivate wheat. Due to its development in different cultures have been many developments in technology and industry, however all the processes that are designed to make bread have had a common purpose and simple, the conversion of wheat four in a food spongy and appetizing. This objective has been achieved through a series of stages are common as the mixture of water and four with yeast, salt and other ingredients individuals in appropriate proportions; the generation of specific aroma and favor through fermentation and the development a structure of gluten in combination with the application of mechanical energy during the kneading and the subsequent acquisition of a fixed and final structure consistent with a nice color through the baking. To achieve this goal which is based on the fermentation of the baking industry has created the term to refer to a sponge pre whose primary function is precisely to change the favor and aroma and contribute to the development of the mass through changes in the properties rheological properties of the mixture. Among the ingredients of the sponge is drawn to the food for yeast known as (APL) that has the primary role of regulating the fermentation through the right mix of ingredients both qualitatively and quantitatively. The study of this combination was raised in this paper using a factorial design of experiments with statistical treatment looking to evaluate the effects of the formulation in combination with the temperature on a response variable called gasification power which indirectly measured the development of the fermentation Liquid sponges that serve as a basis for the preparation of bread mold. The results made it possible to defne a design and the apl an optimum temperature at which the variable response reached the maximu, El pan dentro de sus múltiples formas es uno de los alimentos más antiguos y ampliamente consumidos por la humanidad; su aparición no se conoce a ciencia cierta, pero se presume que fue en el oriente medio, lugar donde empezó a cultivarse el trigo. Debido a su evolución en las diferentes culturas han sido muchos los desarrollos tecnológicos e industriales; sin embargo, todos los procesos que han sido diseñados para la fabricación del pan han tenido una finalidad común y simple: la conversión de la harina de trigo en un alimento esponjoso y apetitoso. Este objetivo se ha logrado a través de una serie de fases comunes como son la mezcla de agua y harina, junto con la levadura, sal y otros ingredientes particulares en proporciones adecuadas, así como la generación de sabor y aroma específicos mediante la fermentación y el desarrollo de una estructura de gluten en combinación con la aplicación de energía mecánica durante el amasado y la obtención posterior de una estructura final fija y consistente con un color agradable mediante el horneado. Para lograr este objetivo que se fundamenta en los procesos de fermentación, la industria de la panificación ha creado el término esponja para referirse a un preferente cuya función principal es precisamente modificar el sabor y aroma y contribuir al desarrollo final de la masa mediante cambios en las propiedades reológicas de la mezcla. Entre los ingredientes de la esponja se destaca el alimento para levadura, conocido por sus iniciales como APL, el cual tiene como función principal la de regular la fermentación mediante la combinación adecuada, tanto cualitativa, como cuantitativa, de los ingredientes. El estudio de esta combinación se planteó en el presente trabajo con base en un diseño factorial de experimentos con tratamiento estadístico buscando evaluar los efectos de la formulación en combinación con la temperatura sobre una variable, respuesta denominada poder de gasificación la cual midió indirectamente el desarrollo
- Published
- 2024
10. DESARROLLO Y CARACTERIZACIÓN DE BIOPELÍCULAS A PARTIR DE MEZCLAS DE ALMIDÓN DE MAÍZ - PAPA, SORBITOL Y ACEITE ESENCIAL DE ORÉGANO (Origanum vulgare).
- Author
-
León Moncada, Alexandra, Bravo Aranibar, Noemi, Pandia Estrada, Silvia, Aleman Polo, Miguel, and Romero Santivañez, Renzo
- Subjects
STARCH ,FACTORIAL experiment designs ,ESSENTIAL oils ,BACILLUS cereus ,ANALYSIS of variance ,CORNSTARCH ,SORBITOL - Abstract
Copyright of Revista de la Sociedad Química del Perú is the property of Sociedad Quimica del Peru and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2022
- Full Text
- View/download PDF
11. Precipitación salina de un extracto crudo con actividad celulolítica producido por Aspergillus niger UC33.
- Author
-
Morales Borrell, Dayana, Baryolo González, Linnet, Mora González, Néstor, Ramos Sánchez, Luis Beltrán, and Pérez Sánchez, Amaury
- Subjects
AMMONIUM sulfate ,ASPERGILLUS niger ,ION exchange chromatography ,EXPERIMENTAL design ,CELLULASE ,SOLID-state fermentation - Abstract
Copyright of Revista Colombiana de Investigaciones Agroindustriales is the property of Revista Colombiana de Investigaciones Agroindustriales del Centro Agropecuario Sena Buga and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2022
- Full Text
- View/download PDF
12. Control scheme selection and optimal tuning in industrial process control using factorial experiment design.
- Author
-
Roberto Acosta-Villamil, David, Fernando Noguera-Polania, José, Verdeza-Villalobos, Arnaldo, Luz Foliaco-Romero, Blanca, Fernanda Rincón-Montenegro, Adriana, and Enrique Sanjuan-Mejía, Marco
- Subjects
- *
FACTORIAL experiment designs , *PROCESS control systems , *ENERGY consumption , *PID controllers , *PROTOTYPES , *MANUFACTURING processes - Abstract
In this study, a novel experimental approach for the optimal selection of an actuator-based control strategy is presented. The proposed approach is a two-stage method: first, a two-level factorial experiment design with n factors (2n) was applied to compare different control schemes. Schemes comparison was carried out in terms of energy consumption and closed-loop performance. For the best relative scheme, a Central Composite Face-centered (CCF) design was completed obtaining the controller parameters that optimize the performance in terms of the Integral Absolute Error (IAE) while operating in a region of low energy consumption. The proposed approach was experimentally tested using real data obtained from a laboratory prototype plant. Some experimental tests illustrating the suitability of our method are shown at the end of this article. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
13. La Importancia, Historia y Aplicaciones del Diseño de Experimentos en la Industria.
- Author
-
Ramírez Tapia, Ricardo, Ríos Lira, Armando Javier, and Pantoja Pacheco, Yaquelin Verenice
- Abstract
Copyright of Congreso Internacional de Investigacion Academia Journals is the property of PDHTech, LLC and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2022
14. Definición de dosis de nitrógeno, fósforo y potasio para una máxima producción del maíz híbrido Advanta 9313 mediante el diseño central compuesto.
- Author
-
Carlos Gavilánez-Luna, Freddy and José Gómez-Vargas, María
- Subjects
GRAIN yields ,ANALYSIS of variance ,GRAIN drying ,CROP management ,EXPERIMENTAL design ,GRAIN - Abstract
Copyright of Revista Ciencia y Tecnología Agropecuaria is the property of Agrosavia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2022
- Full Text
- View/download PDF
15. Costo conductual, modo de interacción y adicción a las redes sociales
- Author
-
Leonardo Pardo Jaime, Psi and Maria Liliana Muñoz Rojas, Ma
- Subjects
adicción a las redes sociales ,diseño factorial ,elección ,costo conductual ,Psychology ,BF1-990 - Abstract
La presente investigación tuvo como objetivo determinar si el costo conductual influye la elección del modo de interacción y el efecto de la adicción a las redes sociales sobre ésta. Para la selección de la muestra se aplicó el Cuestionario de Adicción a las Redes Sociales (ARS) a 306 estudiantes universitarios, 140 hombres y 166 mujeres con edades comprendidas entre los 18 y 42 años (X=22,34), luego se organizaron los puntajes en cuartiles y se seleccionaron a nueve personas del primer cuartil y nueve del último cuartil. Una vez hecho esto, se asignaron en grupos de tres personas, y cada grupo fue asignado dentro de una condición del diseño factorial. El experimento consistió en realizar una entrevista que podía contar con 10 o 16 preguntas (costo conductual), donde el participante elegía realizarla a través de una red social o de forma presencial, dependiendo de la condición asignada. En el análisis de resultados se utilizó el estadístico Kruskal – Wallis y la prueba U de Mann - Whitney para establecer si existen diferencias entre la elección por costo conductual y los cuartiles elegidos respectivamente. Los resultados demostraron que la elección tiende a ser por la opción menos costosa, sin importar la presencia, o ausencia, de adicción a las redes sociales.
- Published
- 2020
- Full Text
- View/download PDF
16. A Modelling Study by Factorial Design on GNSS Positioning.
- Author
-
Ilci, Veli and Sisman, Yasemin
- Subjects
- *
FACTORIAL experiment designs , *FACTORIALS , *GLOBAL Positioning System , *EXPERIMENTAL design - Abstract
Although researchers have widely studied the analysis and modeling of error sources on Global Navigation Satellite Systems positioning, some of these errors have not been eliminated significantly. Only some of the Global Navigation Satellite System's data are modeled. The present work was undertaken to determine the effect of different variables: season, the number of visible satellites, and dilution of precision on the efficiency of horizontal and vertical CORS (Continuously Operating Reference Stations) positioning. The CORS data was collected at 14 different test points during 600 epochs with 1-second intervals for this aim. Factorial designs supply an efficient solution to understand the impact of several factors on a response variable. A full factorial design with three factors at two levels was applied for these purposes. The main and the interaction effects of factors were analyzed on the CORS horizontal and vertical positioning. According to the full factorial design results, while all main and interaction effects of factors significantly affected the CORS horizontal positioning error, some elements did not affect the CORS vertical positioning error. Also, the regression equations were obtained for all situations to investigate the other level of selected factors in the response variables. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
17. Factores explicativos en la calidad de servicio de las Salas de cine.
- Author
-
Domingo José Martinez Diaz and David Eduardo Juliao Esparragoza
- Subjects
método experimental ,estudio de mercado ,diseño factorial ,cine ,calidad percibida ,Technology (General) ,T1-995 ,Social sciences (General) ,H1-99 - Abstract
El estudio es un diseño experimental que explica si los factores día de la película y tipo de sala influyen en la percepción de la calidad de las salas de cine; para evaluar la percepción de los elementos de la calidad de un servicio se utilizó una escala. El cine es una de las alternativas más frecuentadas de consumo de ocio en Colombia (DANE); la importancia del estudio es contribuir con información para que las salas de cine puedan tomar decisiones asertivas que les permitan implementar estrategias que respondan a los elementos claves que influyen en la satisfacción esperada por la demanda. Con un nivel de significancia del 5 %, se descubrió que las dimensiones tangibilidad y capacidad de respuesta influyen en la percepción de la calidad del servicio de cine. Los hallazgos le permiten a la gerencia de las salas administrar discrecionalmente los factores influyentes en la calidad percibida.
- Published
- 2018
- Full Text
- View/download PDF
18. Remoción de cobre de aguas contaminadas empleando ramnolípidos.
- Author
-
Rodríguez-Gámez, Odalys, Pérez-Macías, Rocio, Aguilera-Rodríguez, Isabel, Pérez-Silva, Rosa María, and Abalos-Rodríguez, Arelis
- Subjects
- *
WATER pollution , *HEAVY metals , *FACTORIAL experiment designs , *ENVIRONMENTAL risk , *RHAMNOLIPIDS , *COPPER - Abstract
The use of rhamnolipids constitutes an attractive and eco-compatible alternative in the remediation of contaminated environments with heavy metals. In the present work, the ability of rhamnolipid produced by P. aeruginosa ORA9 to remove copper in contaminated waters of the Blue Lagoon of El Cobre, was evaluated, to control and reduce the human and environmental risk that these waters represent. The influence of the pH of the rhamnolipid solution (4-10), the contact time (2-10 hours) and the concentration of the biosurfactant (40-120 mg L-1) in the process were studied, through a factorial design Box-Bhenken. An increase in the percentage of copper removal proportional to the contact time and the concentration of the biosurfactant was observed, reaching 48 % removal at 10 h and 120 mg L-1. The results obtained indicate that rhamnolipids can be used in the design of a technology to remove copper in polluted contaminated waters. [ABSTRACT FROM AUTHOR]
- Published
- 2020
19. Mejora de la Producción de Zeaxantina A Partir de Flavobacterium Multivorum.
- Author
-
Núria, Susana, Beata, Snelling, and Conley, Bajorek
- Abstract
Zeaxanthin is an oxygenated carotenoid which may play a critical role in the prevention of cancer and agerelated macular degeneration, the leading cause of blindness in the developed world. [ABSTRACT FROM AUTHOR]
- Published
- 2020
20. Development and Optimization of Amoxicillin Floating Raft System to effectively treat Helicobacter pylori infection.
- Author
-
Kamsali, Akhil, Eranti, Bhargav, Mounika, C. H., Manne, Ravi, Barghav, G. Chaitanya, and Reddy, P. Subba
- Subjects
- *
AMOXICILLIN , *HELICOBACTER pylori , *GUAR gum , *GLYCERYL monostearate , *CALCIUM carbonate - Abstract
Introduction: The aim of the present study was to develop and to characterize the floating raft system (FRS) of Amoxicillin to enhance gastric residence time and drug release to target Helicobacter pylori effectively. Method: In the present study, guar gum, glyceryl monostearate (GMS), calcium carbonate were selected as factors. Gelation duration (h), floating lag time (min), and % Cumulative drug release (CDR) were selected as responses. 23 factorial design with replicates was selected for experimentation. Results: It was observed that guar gum and GMS were the major factors affecting gelation duration, increase in the quantity of both guar gum and GMS increased gelation duration i.e., sustained gelation period (24 h). Floating time increased with an increase in the amount of guar gum and calcium carbonate, whereas an increase in the quantity of GMS decreased floating time. Guar gum, calcium carbonate, and GMS exhibited an antagonistic effect on % CDR. Contour plots were used to identify design space; further numerical analysis yielded 12 best solutions based on desirability. FRS exhibited greater AUCo-t, Cmax, tmax, and t1/2 when compared to marketed formulation approximately 2.30 folds enhancement and prolongation with a sustained release for greater than 24 h that might be due to better gelation. Conclusions: It can be concluded that the floating raft system was successfully developed by the Design of experiment (DoE) application with fewer trails and by utilizing easily available excipients for better floating, gelation, and sustained delivery of the drug. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
21. Optimización del proceso de cocción de quinua utilizando el diseño 3k y la función de deseabilidad: Grado de gelatinización, índice de absorción de agua, índice de solubilidad y desprendimiento de cotiledones
- Author
-
Luis Huamani-H., Alberto, Ponce-Ramírez, Juan Carlos, and Málaga-Juárez, Jorge
- Subjects
- *
STEAM generators , *QUINOA , *GELATION , *FACTORIAL experiment designs , *COTYLEDONS , *SOLUBILITY - Abstract
Optimization of the steam quinoa cooking process was carried out, using a response surface design (RSM) 3-level: 3k factorial, and the multiple response optimization methodology of the desirability function (Dx) was used to find the optimal region, which are improved tools to optimize the variables of a process, evaluate the maximization of the water absorption index (WAI), water solubility index (WSI), degree of gelatinization (GE) and the minimization of cotyledon detachment (DC) of quinoa (Chenopodium quinoa Willd). The equipment used was a vertical cook with a steam generator, the study cooking variables, the steam pressure, and the cooking time. The optimal process values were: Pressure 1.5 kgf.cm-2 and time 8 minutes for the best characteristics of cooked quinoa WSI of 26.411%, WAI of 7.960 (g.g-1), GE of 89.245% and CD of 18.40%, the value of the desirability function as an indicator of multiple responses was 0.798. Knowledge of these characteristics can be a valuable complement in the cooking process and thus contribute to improving the quality of cooked cereals. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
22. Optimization of the enzymatic pre-treatment process for mustard oilseeds using response surface methodology.
- Author
-
Neeharika, T. S. V. R., Rani, K. N. Prasanna, Thirupathi, A., Anjaneyulu, E., Srikanth, K., Devi, B. L. A. Prabhavathi, Prasad, R. B. N., and Jala, R. C. R.
- Subjects
- *
MUSTARD seeds , *ENZYMES , *FACTORIAL experiment designs , *TRICHODERMA reesei , *ASPERGILLUS niger , *INTERMOLECULAR interactions , *OIL & fat extraction , *OILSEEDS - Abstract
In order to investigate the effect of an enzymatic pre-treatment process for the extraction of oil from black mustard seeds (Brassica nigra) using viscozyme, the reaction parameters such as temperature, buffer-to-seed ratio and enzyme concentration were considered as determinant factors in the central composite design. Optimization was carried out according to the four-variable five-level central composite design of experiments. The effects of enzyme concentration (5-12%), temperature (40-55 °C), pH (5.0-6.0), and reaction time (1-7 h) on the free oil liberated were studied. Residual oil was collected by subjecting the treated meal to soxhlet extraction for 4 h. An enzyme dose of 7.5% (w/w), pH 5.0, 50 °C, and 5 h with constant shaking at 450 rpm were found to be optimal conditions. Centrifuging the mixture at 7000 rpm for 30 min separated the oil with a recovery of 71-73.1%. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
23. Desarrollo de un modelo predictivo para la obtención de Maltodextrinas del Almidón de Yuca.
- Author
-
Vicuña Galindo, Eder C., Ara-Rojas, Silvia L., and Villavicencio Sánchez, Nancy
- Subjects
- *
CASSAVA , *FACTORIAL experiment designs , *CASSAVA starch , *MATHEMATICAL models , *ERROR rates , *MALTODEXTRIN , *AMYLASES - Abstract
The objective of this work was to obtain a predictive model of the production of maltodextrins, measured as dextrose equivalents (ED), in terms of four factors: enzyme concentration, substrate concentration, temperature and time of digestion whose minimum and maximum levels were 20 and 30% m/m, 0,01 and 0,03%, 40 and 60°C, 15 and 30 minutes respectively. The substrate was obtained from the pulp of cassava tubers (Manihot esculenta Crantz), which was characterized and used as raw material to produce starch solutions at 10, 20 and 30% m/m, which were hydrolysed with commercial alpha amylase (300 NKU/g) to produce the maltodextrins. A factorial design 24 was used, and by means of ANOVA and the software Minitab 17 it was determined that all the factors and their interactions, except the interaction temperature-concentration of substrate, were statistically significant for a α = 0,05. Mathematical expression was simplified by considering the factors and their most effective interactions; these being the Temperature, Enzyme Concentration, Time, Substrate Concentration, and the Interaction Temperature-Concentration of enzyme; thus the mathematical model remained as: ED=0,454375+0,128781 x temperatura-0,060186 x [sustrato]-10,249998 x [enzima] +0,065625 x tiempo +5,753121 x temperatura x [enzima] with a deviation s = 0,197, an R² = 99,78% and an average error rate of 1,18%. The model was validated through a residual analysis; as well as using published works, finding good reproducibility in two cases, even when the substrate was not yucca but yam. [ABSTRACT FROM AUTHOR]
- Published
- 2020
24. EFECTO DE TIEMPO Y TIPO DE ELECTROLITO EN LA GENERACIÓN DE PELÍCULAS DE ÓXIDO ANÓDICO SOBRE LA ALEACIÓN DE ALUMINIO AA5083 - H116.
- Author
-
Cely-Bautista, María M., Soto-Duarte, Jorge A., Castellar, Grey, Colpas, Javier Jaramillo, and Romero Mejía, Iván
- Subjects
- *
OXIDE coating , *FACTORIAL experiment designs , *FACTORIALS , *MICROHARDNESS , *ELECTROLYTES - Abstract
El objetivo del siguiente artículo es evaluar la influencia de los parámetros de tiempo y tipo de electrolito en el espesor y dureza de la película generada por oxidación anódica, sobre la aleación de aluminio AA5083-H116. Fueron evaluados electrolitos, tipo oxálico y fosfórico con tiempos de 30 y 45 min de anodizado. La morfología de las películas fue observada mediante microscopía electrónica de barrido (MEB). La dureza de las superficies se evaluó mediante ensayos Vickers. Para validar los resultados fue aplicado un diseño factorial 2². Los resultados mostraron que el electrolito tipo oxálico presenta los mayores valores de espesor y dureza. [ABSTRACT FROM AUTHOR]
- Published
- 2020
25. Diseño factorial 2k para la optimización de la síntesis de nanopartículas de plata para su aplicación en biomateriales.
- Author
-
Alberto Cuervo-Osorio, Giovanni, Escobar-Jaramillo, Mateo, and Patricia Ossa-Orozco, Claudia
- Abstract
Copyright of Revista ION is the property of Universidad Industrial de Santander and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2020
- Full Text
- View/download PDF
26. Metodologías estadísticas utilizadas en la experimentación con materiales poliméricos: una revisión bibliográfica
- Author
-
Correa Álvarez, Cristian David, Aguirre Poblador, Jose Felipe, Baena Peréz, Libia María, Correa Álvarez, Cristian David, Aguirre Poblador, Jose Felipe, and Baena Peréz, Libia María
- Abstract
In this article, a bibliographical review of some methodologies of design of experiments is carried out, focusing on its function and relevance within the experiments, where the importance of the designs of experiments within the investigation is highlighted using examples of the strategies and designs of experiments. In the first place, a review was carried out that would allow the introduction of the concept of design of experiments, how it was conceived, its principles and its relationship with the investigation, including the main elements of which designs of experiments are composed, and some assumptions to be considered at the time of apply an experimental design in research are included. In addition, different methodologies used by some authors in experiments are shown, what they are and a basic notion of the different methodologies used in the research, focusing on the differences between each one of them and why to use them according to the need of the experiment, then from this, different examples of the different experimental design methodologies used in research articles focused on polymeric materials were carried out, in these examples the different variables of the experiment were stood up, what was the purpose of the investigation and why they opted for the design of experiments they mention. Finally, after carrying out the bibliographical review, it was found that in most of the experimental design applied to the field of experimentation, it allows optimizing the resources without the need to make many attempts. In fact, depending on the type of experiment, it will be feasible to choose a design that is accommodate the needs of the researchers, according to the objectives set in the experiment., En este artículo se realiza una revisión bibliográfica de algunas metodologías del diseño de experimentos, enfocándose en su función y relevancia dentro de los experimentos con materiales, donde se resalta la importancia de los diseños de experimentos dentro de la investigación usando ejemplos de estrategias metodológicas, en primer lugar se realizó una revisión que permitiera introducir el concepto de diseño de experimentos, como este fue concebido, sus principios y su relación con la investigación, se incluyen los elementos principales de los cuales se compone un diseño de experimentos, y algunos supuestos a tener en cuenta en el momento de aplicar un diseño experimental en la investigación. Además, se muestran diferentes metodologías utilizas por algunos autores asociadas a los experimentos, se mencionan diferencias entre cada una de ellas y por qué emplearlas de acuerdo con la necesidad del experimento. Luego, se muestran distintos ejemplos de diseño de experimentos usadas en diferentes artículos de investigación enfocados en materiales poliméricos, en estos ejemplos se resaltan las distintas variables del experimento, cuál era el propósito de la investigación y porque se decantaron por el diseño de experimentos que mencionan. Por último, después de realizar la revisión bibliográfica se encontró que en la mayoría de los diseños experimentales aplicado al campo de la experimentación permite optimizar los recursos sin necesidad de realizar una gran cantidad de intentos, de hecho, dependiendo del tipo de experimento será factible elegir un diseño que se acomode a las necesidades de los investigadores, de acuerdo con los objetivos planteados en el experimento.
- Published
- 2023
27. Evaluación del proceso de deshidratado osmóticoen la fruta para la reducción de mermas,utilizando un diseño experimental factorial
- Author
-
Pamela Hidalgo, L Landaeta, and D Venegas
- Subjects
Diseño factorial ,deshidratado osmótico ,Brix ,frutos deshidratados infundidos ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Technology (General) ,T1-995 - Abstract
El propósito de este estudio es evaluar el proceso de deshidratado osmótico para la reducción de mermas de una empresa agroalimentariade la zona dedicada a la elaboración y comercialización de frutos deshidratados infundidos. En la evaluación del proceso, se determinaron las variables que condicionan la etapa de lavado posterior al deshidratado de la fruta.Utilizando un diseño factorial fraccional 2x como herramienta de evaluación y disminución de las mermas del proceso de deshidratación osmótica, se analizaron el efecto del caudal de fruta (gr/s), caudal de agua (L/h) y el número de pasadas de la fruta infundida, en el brix superficial.Los resultados obtenidos demuestran la efectividad que tiene la integración de las técnicas de diseño de experimentos en la definición de parámetros operacionales del proceso productivo. De los resultados obtenidos, la condición que proporciona el brix más cercano al esperado (2,7 °Bx), corresponde a la alternativa que considera una fila de aspersores abiertos (4 aspersores), utilizando un caudal de 868,747 gr/s y1054,74 L/h de fruta y agua respectivamente y 2 pasadas por el shakerpara la reducción de mermas en el proceso.
- Published
- 2019
28. EFECTO DE LA APLICACIÓN DE UN BIOESTIMULANTE EN LA CALIDAD DE UN CULTIVO DE CEBOLLA BLANCA EN EL VALLE DE ANGOSTURA, SINALOA.
- Author
-
Zazueta Moreno, Javier Alan and Contreras Salazar, Ernesto Alonso
- Abstract
Copyright of Congreso Internacional de Investigacion Academia Journals is the property of PDHTech, LLC and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2018
29. Hidrólisis Enzimática de la Proteína de Vísceras de Trucha Arco Íris (Oncorhynchus mykiss): Efecto del tipo de Enzima, Temperatura, pH y Velocidad de Agitación.
- Author
-
Zapata, José E., Moya, Mariluz, and Figueroa, Omar A.
- Subjects
- *
RAINBOW trout , *VISCERA , *HYDROLYSIS , *FACTORIAL experiment designs , *SPEED - Abstract
The degree of hydrolysis (DH) of rainbow trout viscera (Oncorhynchus mykiss) using Alcalase 2.4L, Flavourzyme and Neutrase. Alcalase 2.4L presented higher DH compared with Flavourzyme and Neutrase. Therefore, the process using Alcalasa 2.4L was optimized according to temperature and pH, finding a maximum DH of 24% at pH 8.5 and 45°C in a 500 mL reactor. The process was scaled to a reactor of 7.5 L, in which the effects of the the stirring speed (75-200 RPM) and the presence of deflectors were evaluated. The results indicate that the model satisfactorily fits the DH values in the levels analyzed (R² = 0.96). The DH depends on pH, temperature, type of enzyme, speed of agitation, work scale and presence of baffles in the reactor. This information is of importance for designing the enzymatic hydrolysis processes of an specific substrate. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
30. Aplicación de un diseño factorial 2³ en la extracción asistida por microondas y evaluación de la actividad antioxidante de los compuestos presentes en frutos de Vaccinium meridionale.
- Author
-
Ávila Ávila, Wilson, Medina Vargas, Oscar J., and Moreno Bastidas, Lucía M.
- Subjects
- *
FACTORIAL experiment designs , *FREE radicals , *EXPERIMENTAL design , *VACCINIUM , *ERICACEAE , *ANTHOCYANINS - Abstract
Blueberry (Vaccinium meridionale) forms part of the family Ericaceae; it is a fruit rich in flavonoids and anthocyanins (polyphenols), which have antioxidant properties and also shows some properties suitable for inhibition of free radicals. A 2³ factorial design was performed to investigate the variables effects: temperature, time and the ethanol percentage %, on the antioxidants extraction process by Microwave Assisted Extraction (MAE). The extraction conditions were: temp (343.15-383.15 K), time (5-15 min), ethanol (0- 80%). A factorial design was performed, with a total of 8 experiments, allowing to determine the influence of the relation of the variables related to the extraction process of compounds with antioxidant activity by DPPH· method, getting a first order factorial model with interactions and a 100% reliability level and a R² =1. The experimental design and evaluation of the results were performed with the software R Studio? free version. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
31. EVALUACIÓN DE NANOMEMBRANAS MEDIANTE SOLUCIONES MODELOS DEL PERMEADO DE LA ULTRAFILTRACIÓN DE SALMUERA DE ACEITUNAS.
- Author
-
Cazares Carrión, Karem Y., Abreu Naranjo, Reinier, Álvarez Blanco, Silvia, and Bes Piá, Amparo
- Subjects
- *
NANOFILTRATION , *FACTORIAL experiment designs , *PERMEABILITY , *DENSITY , *PRESSURE - Abstract
The aim of this study was to evaluate nanofiltration using permeate of ultrafiltration treatment of residual brine from making table olives process model solutions. For the experiments realization a factorial design of two levels was considered (2³). The following independent variables were selected: operating pressure, tangential velocity and membrane type. The response variable was permeate flux density. In addition, the Half-Daniel graphic method was used to determine the significant effects. The permeability coefficients of NF 270, NF 245, NF 90 membranes are 9.93, 3.47 and 3.45 L/hm²bar, respectively. The NF 270 membrane has the highest permeability, while the NF 245 and NF 90 have similar values. The standardized effects of the studied factors estimation on the flow density showed that the variables: type of membrane, pressure and its interaction have the greatest influence on the permeate flow density under considered conditions. The liquid tangential velocity and the remaining interactions also have significant effects, but to a lesser degree. The factorial model was significant (pvalue < 0.0001) for a correlation coefficient R² equal to 0.98. This implies that 97.90% of total variation in the studied process was attributed to considered factors. The model is adequate to represent the experimental data with a confidence level of 95%. [ABSTRACT FROM AUTHOR]
- Published
- 2019
32. Modelamiento estadístico de la lixiviación con cianuro de un mineral del municipio de Andes, Colombia, como alternativa al proceso de amalgamación.
- Author
-
Ruiz Córdoba, Jairo A., López Cañas, Carlos A., Carmona Arango, María E., and Bolívar Gómez, William
- Abstract
The results of a research into the cyanide leaching of a sulphurous gold ore with carbonaceous matter are shown. An experimental design of factorial analysis 2k of three variables with replicates in the center was applied, using the response surface method (MRS). Cyanidation tests in rotating bottles were conducted to study the effect of certain selected variables on Au recovery and to determine the optimal parameters to achieve maximum Au recovery in the process. The results obtained show that the mineral presents a high degree of cyanide leachability, obtaining an average Au recovery of 93.65%, with a sodium cyanide [NaCN] concentration of 2.5 g/L and a leaching time of 12 hours. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
33. Using factorial design to increase the efficiency on a small-scale ethanol distillation
- Author
-
Flávio Dias-Mayer, Giseane Fumagalli-Schettert, Paulo Roberto dos Santos-Salbego, Nicholas Islongo-Canabarro, Vanessa Baldo, Marcio Antonio Mazutti, Edson Luiz Foletto, and Ronaldo Hoffmann
- Subjects
destilación de etanol ,diseño factorial ,pequeña escala ,optimización de proceso ,Engineering (General). Civil engineering (General) ,TA1-2040 - Published
- 2016
34. Modelo matemático para la recuperación de oro y zinc mediante el proceso de flotación a partir de minerales sulfurados de zinc marmatitico en la provincia de Casma – Ancash
- Author
-
Aramburú Rojas, Vidal Sixto, Calderón de Alvarado, Julia Marilú, Adama Navarro, Aldo Joel, Ortiz Barreto, Jorge Alberto, Gutiérrez Falcón, Luís Santiago, and Quispe Gallegos, Luís Enrique
- Subjects
caracterización ,recovery ,factorial design ,flotation ,characterization ,diseño factorial ,flotación ,modelo matemático ,mathematical model ,recuperación - Abstract
The present research study demonstrates that the recovery of gold and zinc in gold-containing marmatitic zinc ores is feasible. The recovery of these metals was analyzed by factorial experimental designs, using the reagents: CuSO4, AR-3418 and AR-1242 as independent variables, while all other variables remained constant. As a result of the research, a mathematical model was obtained for the recovery of gold and zinc, performing the adjusted factorial design analysis, as indicated: Recovery of gold (Au) = 83.40+ 0.00600 CuSO4 + 0.110 AR-3418 + 0.035 AR-1242 + 0.000313 CuSO4 * AR 3418+ 0.000275 CuSO4 * AR-1242- 0.00800 AR-3418 * AR-1242 - 0.000011 CuSO4 * AR-3418 * AR-1242. Likewise, the recovery of zinc (Zn) = 73.14 + 0.0100 CuSO4 + 0.132 AR-3418 + 0.051 AR-1242 + 0.000164 CuSO4 * AR-3418 + 0.000131 CuSO4 * AR-1242 - 0.00811 AR-3418 * AR-1242 - 0.000004 CuSO4 * AR-3418 * AR-1242., El presente estudio de investigación demuestra que es viable la recuperación de oro y zinc en minerales de zinc marmatitico con contenido de oro. Se analizó la recuperación de oro y zinc mediante diseños experimentales factoriales, utilizando los reactivos: CuSO4, AR-3418 y AR-1242 como variables independientes; el resto de las variables se mantuvieron constantes. Como resultado de la investigación se obtuvo un modelo para la recuperación de oro y zinc, realizando el análisis del diseño factorial ajustado como se indica: Recuperación de Au = 83.40+0.00600CuSO4+0.110AR-3418+0.035AR-1242+0.000313CuSO4*AR 3418+0.000275CuSO4*AR-1242-0.00800AR-3418*AR-1242 -0.000011CuSO4*AR-3418*AR-1242. Asimismo, la recuperación de Zn = 73.14 +0.0100CuSO4+0.132AR-3418+0.051AR-1242 +0.000164CuSO4*AR-3418 +0.000131CuSO4*AR-1242 -0.00811AR-3418*AR-1242 -0.000004CuSO4*AR-3418*AR-1242.
- Published
- 2022
35. Optimización procesos de floculación y sedimentación con un diseño factorial tratando agua del embalse de Teatinos
- Author
-
Avila Ruiz, Fernando Libardo, Gonzalez, Juan Pablo, and Universidad Santo Tomás Tunja
- Subjects
Turbidity ,Factorial Desing ,Flocculation ,Turbiedad ,Gradiente de velocidad ,Velocity Gradient ,Floculación ,Diseño factorial - Abstract
La planta de tratamiento de agua potable (PTAP) de la ciudad de Tunja, Boyacá suministra agua a una población de aproximadamente 172,548 habitantes. La PTAP tiene procesos de aireación, coagulación, floculación, sedimentación, filtración y desinfección .Sin embargo, las características fisicoquímicas del agua proveniente de la represa teatinos hacen difícil su tratamiento usando coagulación, floculación y sedimentación dado a su baja alcalinidad (4 – 6 mg/L como CaCO3) y su relativo bajo pH (5,7 – 6,3). El objetivo de esta investigación fue el de hacer una optimización de procesos de floculación y de sedimentación a escala de laboratorio usando un ensayo convencional de jarras, con la ayuda de un diseño factorial, para mejorar la remoción de turbiedad. El diseño factorial permitió evaluar tres diferentes gradientes de velocidad (G) en floculación o mezcla lenta(10, 50 y 100 s-1), tres diferentes tiempos de floculación (TF) (10, 15 y 20 minutos) y tres diferentes tiempos de sedimentación (TS) (20, 30 y 40 minutos) observando su impacto sobre la remoción de turbiedad en la prueba de jarras. De acuerdo con los resultados del estudio, las condiciones óptimas de operación encontradas fueron: (G= 100s-1mezcla lenta, TF = 20 minutos y TS = 20 minutos), con las cuales se logró obtener una turbiedad residual de 0,77 UNT, correspondiente a un 78% de remoción. Adicionalmente, aplicando una superficie de respuesta se pudo predecir valores de turbiedades finales de hasta 0,20 UNT en la jarra usando parámetros operacionales de (G=78 s-1, TF= 23minutos y TS = 30 minutos), respectivamente. The water treatment plant (WTP) of Tunja, Boyacá provides drinking water for a population of approximately 172,548 in habitants. The WTP treats a flow rate of 230 L/susing processes of aeration, coagulation, flocculation, sedimentation, filtration, anddisinfection. However, the raw water physicochemical characteristics of the Teatinosreservoir makes difficult its treatment using coagulation, flocculation, and sedimentationdue to its low alkalinity (4 – 6 mg/L as CaCO3) and relatively low pH (5,7 – 6,3). Theobjective of this research was to optimize the flocculation and the sedimentation processfor turbidity removal at the laboratory level using a regular jar tester and a factorialdesign. The factorial design allowed to assess three different velocity gradients (G) inflocculation, or slow mixing (10, 50 y 100 s-1), three different flocculation times (FT)(10, 15 y 20 min.), and three different sedimentation times (ST) (20, 30 y 40 min.),respectively, and their impact on turbidity removal. The results showed that the optimaloperational conditions in the jar test were: (G= 100 s-1, TF = 20 min. y TS = 20 min.),respectively for obtaining a residual turbidity of 0,77 UNT, which correspond to 78% ofturbidity removal. In addition, it was possible to predict final turbidity values of 0,20UNT in the jar test using a surface response methodology, the low turbidity valuecorresponds to operational parameters of (G=78 s-1, TF= 23 min. y TS = 30 min.),respectively. Magíster en Ingeniería Civil con Énfasis en Hidroambiental Maestría
- Published
- 2022
36. Diseño experimental aplicado al desarrollo de jabón líquido a partir de extractos de andiroba y mulateiro
- Author
-
Silva, Rudyere Nascimento Silva and Cavalcante, Heloide de Lima Cavalcante
- Subjects
Liquid soap ,Mulateiro ,Jabón líquido ,Diseño factorial ,Factorial planning ,Planejamento fatorial ,Andiroba ,Sabonete líquido - Abstract
Due to their attractive properties, plant extracts from the Amazon region have made them fundamental raw materials for the manufacture of cosmetic products on the world market. In the creation and development of new products, factorial planning presents itself as an efficient scientific tool to be used. Thus, the objective of this work was to carry out the development of a liquid soap combining the plant extracts of mulateiro and andiroba, since there is no knowledge of any product that combines the actions of both, with the aid of statistical experimental planning. With this statistical tool, it was possible to evaluate the influence of the main components of the formulation (lauryl, amide, amphoteric, plant extract and essence) on the physicochemical properties of the product. After the experimental development, it was found that the proposal to create a liquid soap using two extracts is viable, as there was no physical-chemical imbalance promoted by the combination in the developed formulations. In turn, the factorial design analysis demonstrates that lauryl (sodium lauryl ether sulfate) influenced the following responses: pH, electrical conductivity, viscosity, density and dry residue. The amide (coconut fatty acid diethanolamine) was significant for pH, viscosity and dry residue. The amphoteric component (bezainic amphoteric) influenced the responses to viscosity, density and dry residue. In turn, the essence was significant only for the dry residue response. Finally, the plant extract in the formulations did not show statistical significance in the responses obtained. Por sus atractivas propiedades, los extractos de plantas de la región amazónica los han convertido en materia prima fundamental para la elaboración de productos cosméticos en el mercado mundial. En la creación y desarrollo de nuevos productos, la planificación factorial se presenta como una herramienta científica eficiente a utilizar. Así, el objetivo de este trabajo fue llevar a cabo el desarrollo de un jabón líquido combinando los extractos vegetales de mulateiro y andiroba, ya que no se conoce ningún producto que combine las acciones de ambos, con la ayuda de una planificación experimental estadística. Con esta herramienta estadística fue posible evaluar la influencia de los principales componentes de la formulación (lauril, amida, anfótero, extracto vegetal y esencia) sobre las propiedades fisicoquímicas del producto. Luego del desarrollo experimental, se encontró que la propuesta de crear un jabón líquido a partir de dos extractos es viable, ya que no hubo desequilibrio físico-químico promovido por la combinación en las formulaciones desarrolladas. A su vez, el análisis de diseño factorial demuestra que el lauril (lauril éter sulfato de sodio) influyó en las siguientes respuestas: pH, conductividad eléctrica, viscosidad, densidad y residuo seco. La amida (dietanolamina de ácido graso de coco) fue significativa para el pH, la viscosidad y el residuo seco. El componente anfótero (anfótero bezaínico) influyó en las respuestas a la viscosidad, la densidad y el residuo seco. A su vez, la esencia fue significativa solo para la respuesta del residuo seco. Finalmente, el extracto vegetal en las formulaciones no mostró significación estadística en las respuestas obtenidas. Por suas atraentes propriedades, os extratos vegetais da região amazônica tornaram-se matérias-primas fundamentais para a fabricação de produtos cosméticos no mercado mundial, neste contexto incluem-se os extratos de andiroba e mulateiro que possuem excelentes propriedades benéficas à pele. Na criação e desenvolvimento de novos produtos, o planejamento fatorial apresenta-se como uma ferramenta científica eficiente a ser empregada. Desta forma, o objetivo deste trabalho consistiu em realizar o desenvolvimento de um sabonete líquido combinando os extratos vegetais de mulateiro e andiroba, uma vez que não se tem conhecimento de qualquer produto que combine as ações de ambos, com o auxílio de planejamento experimental estatístico. Com esta ferramenta estatística foi possível avaliar a influência dos principais componentes da formulação (lauril, amida, anfótero, extrato vegetal e essência) nas propriedades físico-químicas do produto. Após o desenvolvimento experimental, verificou-se que a proposta de criação de um sabonete líquido com a utilização dos dois extratos é viável, pois não observou-se desiquilíbrio físico-químico promovido pela combinação nas formulações desenvolvidas. Por sua vez, a análise do planejamento fatorial demonstra que o lauril (lauril éter sulfato de sódio) influenciou as seguintes propriedades: pH, condutividade elétrica, viscosidade, densidade e resíduo seco. A amida (dietanolamina de ácido graxo de coco), por sua vez, influencia o pH, viscosidade e resíduo seco. O componente anfótero (anfótero bezaínico) influenciou as respostas para viscosidade, densidade e resíduo seco. Por fim, a essência foi significativa apenas para a resposta de resíduo seco, enquanto o extrato vegetal nas formulações não apresentou significância estatística nas respostas obtidas.
- Published
- 2022
37. Efecto de la velocidad de calentamiento sobre las propiedades mecánicas y resistencia a la corrosión de aleaciones de titanio modificadas.
- Author
-
Mercedes Cely, Ma., Castellar O., Grey, Pereira C., Jhorman, and Ángel V., Robert
- Subjects
- *
CORROSION resistance , *MECHANICAL behavior of materials , *HEATING , *TITANIUM alloys , *BIOMEDICAL materials - Abstract
Titanium alloys are widely used as biocompatibles materials, due to their chemical stability inside of the body, a good relationship between density/resistance, fatigue resistance, corrosion resistance and other. The capacity of these materials to develop a naturally passive oxide layer on the surface, makinge them favorable for different applications. However, the stability of the film is affected by aggressive environment. Therefore, the surface modification process has been an alternative to improve the corrosion resistance, and some mechanical properties. This research evaluated the effect of the heating rate on the thermal oxidation of titanium alloys (Ti6Al4V). The method consisted in producing oxide films by thermal oxidation at 600, 700 and 800°C at different heating rates 3, 4 and 5 °Cmin-1 and isothermal cooling in furnace. Morphological characterization was carried out through Scanning Electronic Microscopy, and the corrosion resistance test was carried out by potentiodynamic polarization study using Ringer's solution as an electrolyte. The results showed the influence of the temperature and heating rate on the thickness of the oxide layer in factorial design 3². Thermally oxidized samples at 600 and 800°C showed the best results regarding corrosion resistance compared to untreated samples, and the hardness increased 2.5 fold in samples oxidized at 800°C compared to the base alloy. [ABSTRACT FROM AUTHOR]
- Published
- 2018
38. An experimental study of surface roughness in electrical discharge machining of AISI 304 stainless steel.
- Author
-
Hernández-Castillo, Ignacio, Sánchez-López, Orquídea, Lancho-Romero, Guillermo Arturo, and Castañeda-Roldán, Cuauhtémoc Héctor
- Published
- 2018
- Full Text
- View/download PDF
39. OPTIMIZACAO DOS PARAMETOS DE PROCESSO PARA A OBTENCAO DE UM CATALIZADOR DE DOS VIAS La2O3/Cu/Al.
- Author
-
CHIRINOS COLLANTES, Hugo David and PEREZ ALARCON, Renzo Jeampiare
- Subjects
- *
CARBON monoxide , *CATALYSTS , *CALCINATION (Heat treatment) - Abstract
The surface methodology of response to the factorial design was used to relate the catalytic activity in a two-way catalyst and the following process parameters: concentration ratio La2O3 / Cu and La2O3 / Al; matrix weight; impregnation time; the calcination temperature. The factors that influenced directly under the CO reduction efficiency were studied. The objective was to identify the process factors, which had the greatest effect, in the adition to evaluating the interaction between them. It was observed that there is an increase of 0.195%, on average of the CO reduction when the concentration ratio varies from 0.5g to 1.25g and there is an increase of 0.47%, on average, of the CO reduction when the impregnation time varies from 6h to 12h. It is also observed that the effect of the block is significant but negative, there is a significant decrease of 3,7%, in average, in the reduction of CO when using the ratio La2O3 / Al confirming that the catalyst with the aluminum metal presents higher catalytic efficiency in CO reduction. It was also observed that there is an interaction between the immersion time and the calcination temperature and that it had a synergic effect. The linear correlation was determined by the following mathematical equation: y = ... . [ABSTRACT FROM AUTHOR]
- Published
- 2018
40. Evaluación de la resistencia al impacto y a la tracción de un material compuesto de polietileno de alta densidad y guadua usando un diseño factorial 2 ³.
- Author
-
Lemus, Diego F., Niño, Jimmy A., and Rojas, Alberto
- Abstract
Copyright of Comunicaciones en Estadística is the property of Universidad Santo Tomas and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2018
- Full Text
- View/download PDF
41. Estudio comparativo del porcentaje de germinación para variedades Lactuca sativa: huertos sustentables en entornos urbanos.
- Author
-
Bedoya Corrales, Laura Isabel, García Arango, David Alberto, Sepúlveda-Aguirre, Jovany, Echeverri Gutiérrez, Camilo Andrés, and Acosta Agudelo, Leidy Catalina
- Abstract
Introduction: Urban agriculture promotes the cultivation of vegetables in the city, however seeds are required to germinate and obtain seedlings that allow to start this practice. Objective. The present research evaluates the percentage of germination of two varieties of lettuce (Lactuca sativa), Milanesa and Conconina, to determine if there is a significant difference in their germination to obtain seedlings. Materials and methods. A factorial design 22 was developed, taking into consideration the combinations of variety and luminosity; a statistical model was proposed to describe its behavior. Results. The most influential factor in the percentage of germination is the variety, the best results were found Milanesa variety under natural Light conditions. Conclusions. The Milanesa variety is a good option to generate seedlings and, under natural Light conditions, a germination percentage of 92.5% can be obtained, a value higher than that reported by the producer. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
42. Precipitación salina de un extracto crudo con actividad celulolítica producido por Aspergillus niger UC33
- Author
-
Morales, Dayana, Baryolo González, Linnet, Mora González, Néstor, Ramos Sánchez, Luis Beltrán, Pérez Sánchez, Amaury, Morales, Dayana, Baryolo González, Linnet, Mora González, Néstor, Ramos Sánchez, Luis Beltrán, and Pérez Sánchez, Amaury
- Abstract
The purification of cellulase enzymes is a critical step for their production because it is often very expensive. The objective of this study was to evaluate the saline precipitation of cellulases produced by Aspergillus niger UC33 in solid-state fermentation, to increase the yield and purity of the enzyme at the lowest possible cost. The Design-Expert 11.1.2 program was used for the experimental design and the optimization of the experimental conditions. Ammonium sulfate between 60 and 90 % saturation was used for precipitation, among 1 and 3 h of precipitation time were employed and the temperatures applied were 4 and 25 °C. The optimal conditions found to maximize yield and purity were 68.97% saturation with ammonium sulfate, precipitation time of 1.28 h and temperature of 25 °C. Under these conditions, the yield, purity and cost values were: 74.81%, 1.26 and USD $ 0.2609, respectively. The molecular weight of the enzyme was 38.47 kDa and the cellulolytic activity was 31.854 IU., La purificación de enzimas celulasas constituye un paso crítico para su producción debido a que a menudo resulta ser muy costoso. El objetivo de este estudio fue evaluar la precipitación salina de celulasas producidas por Aspergillus niger UC33 en fermentación en estado sólido, para incrementar el rendimiento y pureza de la enzima con el menor costo posible. Se empleó el programa Design-Expert 11.1.2 para el diseño experimental y la optimización de las condiciones experimentales. El sulfato de amonio se utilizó para la precipitación entre 60 y 90 % de saturación, se emplearon entre 1 y 3 h de precipitación y las temperaturas utilizadas fueron 4 y 25 °C. Las condiciones óptimas encontradas para maximizar el rendimiento y la pureza fueron 68,97 % de saturación con sulfato de amonio, tiempo de precipitación de 1,28 h y temperatura de 25 °C. En estas condiciones los valores de rendimiento, pureza y costo, fueron: 74,81 %, 1,26 y USD $ 0,2609, respectivamente. El peso molecular de la enzima fue 38,47 kDa y la actividad celulolítica fue de 31,854 UI.
- Published
- 2022
43. Development and characterization of biofilms from mixtures of corn - potato starch, sorbitol and oregano essential oil (Origanum vulgare)
- Author
-
León Moncada, Alexandra, Bravo Aranibar, Noemi, Pandia Estrada, Silvia, Aleman Polo, Miguel, and Romero Santivañez, Renzo
- Subjects
aceite esencial ,Biopelículas ,Biofilms ,factorial design ,sorbitol ,General Earth and Planetary Sciences ,diseño factorial ,essential oil ,General Environmental Science - Abstract
RESUMEN En el presente trabajo se elaboraron biopelículas mediante el método de casting utilizando diseño factorial multinivel 2x2x3, siendo los factores: concentración de sorbitol (60% y 80%), temperatura de proceso (85°C y 95°C) y proporciones de almidón de papa (P) y almidón de maíz (M): 0%M:100%P, 25%M:75%P y 50%M:50%P, para la determinación de la mejor formulación en base a sus propiedades mecánicas: resistencia a la tracción (RT, N/mm2) y elongación (E, %). Los resultados se aceptaron con un nivel de 95% de confianza (p < 0.05) y mediante comparación de medias LSD. El tratamiento seleccionado fue obtenido empleando sorbitol al 60%, temperatura de proceso al 95°C y proporción de mezcla al 50%P:50%M, obteniéndose 6,23 N/mm2 de RT y 14,67 % de elongación. Esta formulación se empleó como base polimérica para la segunda etapa, donde se adicionó 0, 1 y 2,5 % de aceite esencial de orégano (AEO) utilizando un diseño factor categórico individual, en el que se determinó la influencia del AEO sobre la actividad antimicrobiana. Se seleccionó la biopelícula con 1% de AEO, con un nivel de 95 % de confianza (p < 0,05), la cual mostró un valor de RT de 4,03 N/mm2, 30,21 % de E y actividad antimicrobiana frente a Staphylococcus aureus, seguido de Bacillus cereus. Todos los resultados fueron evaluados mediante análisis de varianza (ANOVA) y aceptados con un nivel de 95 % de confianza (p < 0,05). ABSTRACT In the present work, biofilms were elaborated by means of the casting method using a 2x2x3 multilevel factorial design with a replica, being the factors: sorbitol concentration (60% and 80%), process temperature (85°C and 95°C) and proportions of potato starch (P) and corn starch (M): 0%M:100%P, 25%M:75%P and 50%M:50%P, for the determination of the best formulation based on their mechanical properties: tensile strength (RT, MPa) and elongation (E, %). The results were accepted with a 95% confidence level (p < 0.05) and by comparison of LSD means. The selected treatment was obtained using sorbitol at 60%, process temperature at 95°C and mixing ratio at 50%P:50%M, obtaining 6,23 N/mm2 of RT and 14,67% of elongation. This formulation was used as a polymeric base for the second stage, where 0, 1 and 2,5% of oregano essential oil (AEO) was added using an individual categorical factor design, in which the influence of AEO on antimicrobial activity was determined. The biofilm with 1% AEO was selected, with a 95% confidence level (p < 0,05), which showed an N/mm2 value of 4,03 MPa, 30,21% E, and antimicrobial activity against Staphylococcus aureus, followed by Bacillus cereus. All results were evaluated by analysis of variance (ANOVA) and accepted at a 95% confidence level (p < 0,05).
- Published
- 2022
- Full Text
- View/download PDF
44. Análisis de poder estadístico y cálculo de tamaño de muestra en R: Guía práctica
- Author
-
Leongómez, Juan David
- Subjects
Tamaño de muestra ,ANOVA ,Superpower ,Poder estadístico ,YouTube ,pwr ,Correlación ,Medidas repetidas ,Video ,G*Power ,Ciencia abierta ,Potencia estadística ,jpower ,jamovi ,Prueba t ,Diseños mixtos ,Error tipo I ,Diseño factorial ,Error tipo II ,Alfa ,Tamaño de efecto - Abstract
Opciones gratuitas y abiertas, con énfasis en los paquetes {pwr} y {Superpower} para R. La guía se encuentra publicada en Zonodo http://doi.org/10.5281/zenodo.3988777
- Published
- 2022
- Full Text
- View/download PDF
45. EVALUACIÓN DE NANOMEMBRANAS MEDIANTE SOLUCIONES MODELOS DEL PERMEADO DE LA ULTRAFILTRACIÓN DE SALMUERA DE ACEITUNAS
- Author
-
Karem Y. Cazares Carrión, Reinier Abreu Naranjo, Silvia Álvarez Blanco, and Amparo Bes Piá
- Subjects
membranas ,nofiltración ,permeabilidad ,diseño factorial ,Special industries and trades ,HD9000-9999 - Abstract
El objetivo de este estudio fue evaluar la nanofiltración mediante el uso de soluciones modelos del permeado de la ultrafiltración en el tratamiento de salmuera residual del proceso de elaboración de aceitunas de mesa. Para la realización de los experimentos se consideró un diseño factorial de dos niveles (23 ). Como variables independientes fueron seleccionadas: la presión operación, velocidad tangencial y tipo de membrana. La variable de respuesta fue densidad de flujo de permeado. Además, se usó el método gráfico de Half-Daniel para determinar los efectos significativos. El coeficiente de permeabilidad de las membranas NF 270, NF 245, NF 90 es de 9,93; 3,47 y 3,45 L/hm2 bar, respectivamente. Siendo la membrana NF 270 la de mayor permeabilidad, mientras que la NF 245 y NF 90 presentó valores similares. La estimación de los efectos estandarizados de los factores estudiados sobre la densidad de flujo arrojó que las variables: tipo de membrana, presión y su interacción ejercieron mayor influencia sobre la densidad de flujo de permeado en las condiciones consideradas. La velocidad tangencial del líquido y las interacciones restantes presentaron efectos significativos, pero en menor grado. El modelo factorial resultó significativo (p-valor < 0,0001) para un coeficiente de correlación R2 igual a 0,98. Lo que implica que el 97,90% de la variación total en el proceso estudiado se atribuyó a los factores considerados. Por lo que se concluye que modelo es adecuado para representar los datos experimentales con un nivel de confianza del 95%.
- Published
- 2019
46. Estudio numérico para evaluar las características hidrodinámicas de perfiles NACA aplicados al rodete de una microturbina axial
- Author
-
Yanza Vargas, Jorge Israel and Reinoso Avecillas, Fran Zhovani
- Subjects
HIDRODINÁMICA ,DISEÑO FACTORIAL ,DINÁMICA DE FLUIDOS - SIMULACIÓN POR COMPUTADORES ,MICROTURBINAS ,INGENIERÍA MECÁNICA - Abstract
Este trabajo investiga numéricamente, mediante la combinación de CFD y un diseño factorial, el comportamiento hidrodinámico de un perfil NACA aplicado al rodete de una microturbina hidráulica de flujo axial. Se concluye que es posible incrementar un 8% el rendimiento de la turbina empleando un perfil NACA 5412 a un ángulo de ataque de 5°. Combining CFD and a factorial design, this work numerically investigates the hydrodynamic behavior of a NACA airfoil applied to the runner of an propeller microturbine. In this way, it is possible to increase by 8% the efficiency of the turbine using a NACA 5412 airfoil at an angle of attack of 5°.
- Published
- 2022
47. USO DEL DISEÑO FACTORIAL EN LOS ENSAYOS DE LIBERACIÓN CONTROLADA DEL ÁCIDO 1,3 INDOLACÉTICO CARGADO EN MATRICES DE QUITOSANO.
- Author
-
Valderrama Negrón, Ana, Jacinto Hernández, Christian, Ponce García, Susana, and Manrique Pollera, Luis
- Abstract
Copyright of Revista de la Sociedad Química del Perú is the property of Sociedad Quimica del Peru and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2017
- Full Text
- View/download PDF
48. Effect of particle size and oxidant concentration in the yield of humic acids from mineral coal using response surface methodology.
- Author
-
Pájaro-Payares, Adolfo A., Espinosa-Fuentes, Eduardo A., Colpas-Castillo, Fredy, Rodríguez-Ruiz, Johana, Fernández-Maestre, Roberto, and Meza-Fuentes, Edgardo
- Subjects
HUMIC acid analysis ,OXIDATION ,BITUMINOUS coal - Abstract
Copyright of Revista de la Academia Colombiana de Ciencias Exactas, Físicas y Naturales is the property of Academia Colombiana de Ciencias Exactas, Fisicas y Naturales and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2017
- Full Text
- View/download PDF
49. Una prueba del proceso de percepción-elección mediante la encuesta factorial en Venezuela.
- Author
-
Antonio Rodríguez, Juan and Birkbeck, Christopher
- Published
- 2017
50. Formulación y Optimización del Sistema Flotante de Amoxicilina para el tratamiento efectivo de la infección por Helicobacter pylori
- Author
-
Chaitanya Barghav G, Subba Reddy P, Akhil Kamsali, Bhargav Eranti, Ravi Manne, and Mounika Ch
- Subjects
Sustained delivery ,Guar gum ,Helicobacter pylori ,Chemistry ,Floating raft system ,Cmax ,Pharmaceutical Science ,Factorial experiment ,RM1-950 ,Estudios in vivo ,Glyceryl monostearate ,Lag time ,History and Philosophy of Science ,Invivo studies ,Drug release ,Factorial design ,Food science ,Therapeutics. Pharmacology ,Sistema flotante ,Design space ,Diseño factorial ,factorial Design - Abstract
The authors thank DST-FIST Lab (RERDS-CPR), R&D Director, for providing necessary facilities and assistance to perform this research work., Introducción: El objetivo del presente estudio fue formular y caracterizar el Sistema Flotante (FRS, siglas en Inglés) de Amoxicilina para prolongar el tiempo de residencia gástrica y liberación del fármaco para el enfoque efectivo del Helicobacter pylori. Método: Para el presente estudio se seleccionaron como factores goma guar, Monoestearato de glicerilo (GMS), carbonato de calcio. Como reacciones, se seleccionaros el período de congelación (h), el lapso de flotación (min), y el porcentaje acumulado de liberación del fármaco (CDR). Para la experimentación se seleccionaron el diseño factorial 23 con réplicas. Resultados: Se observó que la goma guar y el GMS fueron los factores principales que afectaron el período de congelación y mostraron un efecto sinérgico (positivo). Mientras que la goma guar y el carbonato de calcio mostraron un efecto positivo y el GMS mostró un efecto antagónico (negativo) en el lapso de flotación. El porcentaje CDR mostró un efecto antagónico en todos los factores. Se emplearon curvas de nivel para identificar el diseño del espacio, análisis numéricos posteriores produjeron 12 soluciones óptimas en base a la deseabilidad. El FRS mostró un mayor AUCo-t, Cmax, tmaxy t1/2 cuando se comparó con la formulación comercial, aproximadamente 2.30 cambios múltiplos y prolongación con liberación sostenida por más de 24 h que pudo deberse a una mejor congelación. Conclusiones: Se puede concluir que el sistema flotante se desarrolló satisfactoriamente por la aplicación del Diseño de Experimentos (DoE) con menores ensayos y utilizando fácilmente los excipientes disponibles para una mejor flotación, congelación y suministro constante del fármaco., Introduction: The aim of the present study was to develop and to characterize the floating raft system (FRS) of Amoxicillin to enhance gastric residence time and drug release to target Helicobacter pylori effectively. Method: In the present study, guar gum, glyceryl monostearate (GMS), calcium carbonate were selected as factors. Gelation duration (h), floating lag time (min), and % Cumulative drug release (CDR) were selected as responses. 23 factorial design with replicates was selected for experimentation. Results: It was observed that guar gum and GMS were the major factors affecting gelation duration, increase in the quantity of both guar gum and GMS increased gelation duration i.e., sustained gelation period (24 h). Floating time increased with an increase in the amount of guar gum and calcium carbonate, whereas an increase in the quantity of GMS decreased floating time. Guar gum, calcium carbonate, and GMS exhibited an antagonistic effect on % CDR. Contour plots were used to identify design space; further numerical analysis yielded 12 best solutions based on desirability. FRS exhibited greater AUCo-t, Cmax, tmax, and t1/2 when compared to marketed formulation approximately 2.30 folds enhancement and prolongation with a sustained release for greater than 24 h that might be due to better gelation. Conclusions: It can be concluded that the floating raft system was successfully developed by the Design of experiment (DoE) application with fewer trails and by utilizing easily available excipients for better floating, gelation, and sustained delivery of the drug.
- Published
- 2020
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.