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11 results on '"Dumitru, R.S."'

1. Occupational exposure to organic dust increases lung cancer risk in the general population

Author

Peters, S., Kromhout, H., Olsson, A.C., Wichmann, H.E., Bruske, I., Consonni, D., Landi, M.T., Caporaso, N., Siemiatycki, J., Richiardi, L., Mirabelli, D., Simonato, L., Gustavsson, P., Plato, N., Jockel, K.H., Ahrens, W., Pohlabeln, H., Boffetta, P., Brennan, P., Zaridze, D., Cassidy, A., Lissowska, J, Szeszenia-Dabrowska, N., Rudnai, P., Fabianova, E., Forastiere, F., Bencko, V., Foretova, L., Janout, V., Stucker, I., Dumitru, R.S., Benhamou, S., Bueno-de-Mesquita, B., Kendzia, B., Pesch, B., Straif, K., Bruning, T., Vermeulen, R., Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Peters, S., Kromhout, H., Olsson, A.C., Wichmann, H.-E., Brüske, I., Consonni, D., Landi, M.T., Caporaso, N., Siemiatycki, J., Richiardi, L., Mirabelli, D., Simonato, L., Gustavsson, P., Plato, N., Jöckel, K.-H., Ahrens, W., Pohlabeln, H., Boffetta, P., Brennan, P., Zaridze, D., Cassidy, A., Lissowska, J., Szeszenia-Dabrowska, N., Rudnai, P., Fabianova, E., Forastiere, F., Bencko, V., Foretova, L., Janout, V., Stücker, I., Dumitru, R.S., Benhamou, S., Bueno-de-Mesquita, B., Kendzia, B., Pesch, B., Straif, K., Brüning, T., Vermeulen, R., Risk Assessment of Toxic and Immunomodulatory Agents, and Dep IRAS

Subjects
Adult, Male, Pulmonary and Respiratory Medicine, Canada, Lung Neoplasms, case-control study, Population, Medizin, Cumulative Exposure, Logistic regression, Article, Toxicology, Occupational Exposure, Environmental health, Humans, Medicine, Lung cancer, education, Aged, Asthma, education.field_of_study, business.industry, Smoking, Case-control study, Public Health, Environmental and Occupational Health, Dust, Middle Aged, medicine.disease, Occupational exposure to organic du, respiratory tract diseases, Europe, Occupational Diseases, lung cancer, Quartile, Case-Control Studies, Meta-analysis, Female, business
Abstract

Background: Organic dust is a complex mixture of particulate matter from microbial, plant or animal origin. Occupations with exposure to animal products have been associated with an increased lung cancer risk, while exposure to microbial components (eg, endotoxin) has been associated with a decreased risk. To date there has not been a comprehensive evaluation of the possible association between occupational organic dust exposure (and its specific constituents) and lung cancer risk in the general population. Methods: The SYNERGY project has pooled information on lifetime working and smoking from 13 300 lung cancer cases and 16 273 controls from 11 case - control studies conducted in Europe and Canada. A newly developed general population job-exposure matrix (assigning no, low or high exposure to organic dust, endotoxin, and contact with animals or fresh animal products) was applied to determine level of exposure. ORs for lung cancer were estimated by logistic regression, adjusted for age, sex, study, cigarette pack-years, time since quitting smoking, and ever employment in occupations with established lung cancer risk. Results: Occupational organic dust exposure was associated with increased lung cancer risk. The second to the fourth quartile of cumulative exposure showed significant risk estimates ranging from 1.12 to 1.24 in a dose-dependent manner (p

Published
2012

2. Occupational exposure to organic dust increases lung cancer risk in the general population.

Author

Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Peters, S., Kromhout, H., Olsson, A.C., Wichmann, H.E., Bruske, I., Consonni, D., Landi, M.T., Caporaso, N., Siemiatycki, J., Richiardi, L., Mirabelli, D., Simonato, L., Gustavsson, P., Plato, N., Jockel, K.H., Ahrens, W., Pohlabeln, H., Boffetta, P., Brennan, P., Zaridze, D., Cassidy, A., Lissowska, J, Szeszenia-Dabrowska, N., Rudnai, P., Fabianova, E., Forastiere, F., Bencko, V., Foretova, L., Janout, V., Stucker, I., Dumitru, R.S., Benhamou, S., Bueno-de-Mesquita, B., Kendzia, B., Pesch, B., Straif, K., Bruning, T., Vermeulen, R., Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Peters, S., Kromhout, H., Olsson, A.C., Wichmann, H.E., Bruske, I., Consonni, D., Landi, M.T., Caporaso, N., Siemiatycki, J., Richiardi, L., Mirabelli, D., Simonato, L., Gustavsson, P., Plato, N., Jockel, K.H., Ahrens, W., Pohlabeln, H., Boffetta, P., Brennan, P., Zaridze, D., Cassidy, A., Lissowska, J, Szeszenia-Dabrowska, N., Rudnai, P., Fabianova, E., Forastiere, F., Bencko, V., Foretova, L., Janout, V., Stucker, I., Dumitru, R.S., Benhamou, S., Bueno-de-Mesquita, B., Kendzia, B., Pesch, B., Straif, K., Bruning, T., and Vermeulen, R.

Published
2012

3. Lung cancer and socioeconomic status in a pooled analysis of case-control studies

Author

Hovanec, J., Siemiatycki, J., Conway, D. I., Olsson, A., Stücker, I., Guida, F., Jockel, K. -H., Pohlabeln, H., Ahrens, W., Brüske, I., Wichmann, H. -E., Gustavsson, P., Consonni, D., Merletti, F., Richiardi, L., Simonato, L., Fortes, C., Parent, M. -E., McLaughlin, J., Demers, P., L, i, M. T., Caporaso, N., Tardón, A., Zaridze, D., Szeszenia-Dabrowska, N., Rudnai, P., Lissowska, J., Fabianova, E., Field, J., Dumitru, R. S., Bencko, V., Foretova, L., Janout, V., Kromhout, H., Vermeulen, R., Boffetta, P., Straif, K., Schüz, J., Kendzia, B., Pesch, B., Brüning, T., Behrens, T., Hovanec, J. and Siemiatycki, J. and Conway, D.I. and Olsson, A. and Stücker, I. and Guida, F. and Jockel, K.-H. and Pohlabeln, H. and Ahrens, W. and Brüske, I. and Wichmann, H.-E. and Gustavsson, P. and Consonni, D. and Merletti, F. and Richiardi, L. and Simonato, L. and Fortes, C. and Parent, M.-E. and McLaughlin, J. and Demers, P. and Landi, M.T. and Caporaso, N. and Tardón, A. and Zaridze, D. and Szeszenia-Dabrowska, N. and Rudnai, P. and Lissowska, J. and Fabianova, E. and Field, J. and Dumitru, R.S. and Bencko, V. and Foretova, L. and Janout, V. and Kromhout, H. and Vermeulen, R. and Boffetta, P. and Straif, K. and Schüz, J. and Kendzia, B. and Pesch, B. and Brüning, T. and Behrens, T., Ruhr-Universität Bochum [Bochum], Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM), University of Glasgow, Karolinska Institutet [Stockholm], Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Universitätsklinikum Essen [Universität Duisburg-Essen] (Uniklinik Essen), Leibniz Institute for Prevention Research and Epidemiology - BIPS, Leibniz Association, University of Bremen, Helmholtz-Zentrum München (HZM), Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, University of Turin, Universita degli Studi di Padova, Istituto Dermopatico dell'Immacolata, Institut Armand Frappier (INRS-IAF), Institut National de la Recherche Scientifique [Québec] (INRS)-Réseau International des Instituts Pasteur (RIIP), Public Health Ontario - Santé publique Ontario, Occupational Cancer Research Centre, National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH), CIBER de Epidemiología y Salud Pública (CIBERESP), Russian Cancer Research Centre, Nofer Institute of Occupational Medicine (NIOM), National center for public health [Hungary], Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology (MCMCC), Regional Authority of Public Health [Slovaquia] (RAPH), Ministry of Health of the Slovak Republic [Slovaquia], University of Liverpool, National Institute of Public Health [Romania] (INSP), Charles University [Prague] (CU), Masaryk University [Brno] (MUNI), Palacky University Olomouc, Ostravská univerzita / University of Ostrava, Utrecht University [Utrecht], Icahn School of Medicine at Mount Sinai [New York] (MSSM), Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), This study was supported by the German Social Accident Insurance, grant number FP 271. Grant sponsors of the individual studies were the Canadian Institutes for Health Research and Guzzo-SRC Chair in Environment and Cancer, National Cancer Institute of Canada, Canadian Cancer Society, Occupational Cancer Research Centre, Workplace Safety and Insurance Board, Canadian Cancer Society, and Cancer Care Ontario, Grant sponsor: European Commission’s INCO Copernicus program, Grant number: IC15-CT96-0313, Grant sponsor: European Union Nuclear Fission Safety Program, Grant number: F14P-CT96-0055, Grant sponsors: French Agency of Health Security (ANSES), Fondation de France, French National Research Agency (ANR), National Institute of Cancer (INCA), Fondation pour la Recherche Medicale, French Institute for Public Health Surveillance (InVS), Health Ministry (DGS), Organization for the Research on Cancer (ARC), and FrenchMinistry of work, solidarity, and public function (DGT), Grant sponsor: Federal Ministry of Education, Science, Research, and Technology, Grant number: 01 HK 173/0), Grant sponsor: Federal Ministry of Science, Grant number: 01 HK 546/8, Grant sponsor: Ministry of Labour and Social Affairs, Grant number: IIIb7-27/13, Grant sponsor: Research Grants Council of the Hong Kong Special Administrative Region, China, Grant number: CUHK4460/03M, Grant sponsors: Environmental Epidemiology Program of the Lombardy Region, INAIL, Italian Association for Cancer Research, Region Piedmont, Compagnia di San Paolo, Lazio Region, Health Research Council of New Zealand, New Zealand Department of Labour, Lottery Health Research, Cancer Society of New Zealand, Grant sponsor: Polish State Committee for Scientific Research, Grant number: SPUB-M-COPERNICUS/P-05/DZ-30/99/2000, Grant sponsors: Instituto Universitario de Oncologia, Universidad de Oviedo, Asturias, Fondo de Investigacion Sanitaria (FIS) and Ciber de Epidemiologia y Salud Publica (CIBERESP), Swedish Council for Work Life Research and Swedish Environmental Protection Agency, Dutch Ministry of Health, Welfare and Sports, National Institute of Public Health and the Environment, and Europe Against Cancer Program, Roy Castle Foundation, and Intramural Research Program of the National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, Maryland., Nofer Institute of Occupational Medicine, Lodz, Poland, Courcelles, Michel, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Helmholtz Zentrum München = German Research Center for Environmental Health, Università degli studi di Torino = University of Turin (UNITO), Università degli Studi di Padova = University of Padua (Unipd), One Health Chemisch, and dIRAS RA-2

Subjects
Genetics and Molecular Biology (all), Male, Lung Neoplasms, Economics, [SDV]Life Sciences [q-bio], Medizin, lcsh:Medicine, Social Sciences, MESH: Logistic Models, Sex Factor, cancer risk, Biochemistry, MESH: Occupational Exposure, Lung and Intrathoracic Tumors, lung tumor, Geographical Locations, Habits, Small Cell Lung Cancer, Biochemistry, Genetics and Molecular Biology (all), Agricultural and Biological Sciences (all), MESH: Risk Factors, Risk Factors, middle aged, Medicine and Health Sciences, Smoking Habits, Odds Ratio, Public and Occupational Health, lcsh:Science, health care economics and organizations, MESH: Aged, MESH: Middle Aged, adult, Age Factors, Socioeconomic Aspects of Health, educational statu, [SDV] Life Sciences [q-bio], Europe, Professions, female, Oncology, Anatomy, Research Article, Employment, MESH: Smoking, Canada, Histology, Logistic Model, sex difference, education, Jobs, Article, smoking, statistical model, Age Factor, MESH: Social Class, Sex Factors, MESH: Sex Factors, MESH: Canada, Occupational Exposure, Humans, controlled study, human, social cla, Aged, MESH: Age Factors, Behavior, MESH: Humans, meta analysi, Risk Factor, lcsh:R, disease association, high risk population, Small cell lung cancer, Smoking habits, Lung and intrathoracic tumors, Socioeconomic aspects of health, Cancers and Neoplasms, Biology and Life Sciences, case control study, lung carcinogenesi, social statu, MESH: Male, MESH: Odds Ratio, MESH: Lung Neoplasms, Health Care, Lung Neoplasm, lung cancer, Logistic Models, age, Social Class, Labor Economics, People and Places, lcsh:Q, Population Groupings, pathology, MESH: Europe, MESH: Female
Abstract

An association between low socioeconomic status (SES) and lung cancer has been observed in several studies, but often without adequate control for smoking behavior. We studied the association between lung cancer and occupationally derived SES, using data from the international pooled SYNERGY study. Twelve case-control studies from Europe and Canada were included in the analysis. Based on occupational histories of study participants we measured SES using the International Socio-Economic Index of Occupational Status (ISEI) and the European Socio-economic Classification (ESeC). We divided the ISEI range into categories, using various criteria. Stratifying by gender, we calculated odds ratios (OR) and 95% confidence intervals (CI) by unconditional logistic regression, adjusting for age, study, and smoking behavior. We conducted analyses by histological subtypes of lung cancer and subgroup analyses by study region, birth cohort, education and occupational exposure to known lung carcinogens. The analysis dataset included 17,021 cases and 20,885 controls. There was a strong elevated OR between lung cancer and low SES, which was attenuated substantially after adjustment for smoking, however a social gradient persisted. SES differences in lung cancer risk were higher among men (lowest vs. highest SES category: ISEI OR 1.84 (95% CI 1.61-2.09); ESeC OR 1.53 (95% CI 1.44-1.63)), than among women (lowest vs. highest SES category: ISEI OR 1.54 (95% CI 1.20-1.98); ESeC OR 1.34 (95% CI 1.19-1.52)). SES remained a risk factor for lung cancer after adjustment for smoking behavior. Funding: This study was supported by the German Social Accident Insurance, grant number FP 271. Grant sponsors of the individual studies were the Canadian Institutes for Health Research and Guzzo-SRC Chair in Environment and Cancer, National Cancer Institute of Canada, Canadian Cancer Society, Occupational Cancer Research Centre, Workplace Safety and Insurance Board, Canadian Cancer Society, and Cancer Care Ontario; Grant sponsor: European Commission’s INCO Copernicus program; Grant number: IC15-CT96-0313; Grant sponsor: European Union Nuclear Fission Safety Program; Grant number: F14P-CT96-0055; Grant sponsors: French Agency of Health Security (ANSES), Fondation de France, French National Research Agency (ANR), National Institute of Cancer (INCA), Fondation pour la Recherche Medicale, French Institute for Public Health Surveillance (InVS), Health Ministry (DGS), Organization for the Research on Cancer (ARC), and FrenchMinistry of work, solidarity, and public function (DGT); Grant sponsor: Federal Ministry of Education, Science, Research, and Technology; Grant number: 01 HK 173/0); Grant sponsor: Federal Ministry of Science; Grant number: 01 HK 546/8; Grant sponsor: Ministry of Labour and Social Affairs; Grant number: IIIb7-27/13; Grant sponsor: Research Grants Council of the Hong Kong Special Administrative Region, China; Grant number: CUHK4460/03M; Grant sponsors: Environmental Epidemiology Program of the Lombardy Region, INAIL, Italian Association for Cancer Research, Region Piedmont, Compagnia di San Paolo, Lazio Region, Health Research Council of New Zealand, New Zealand Department of Labour, Lottery Health Research, Cancer Society of New Zealand; Grant sponsor: Polish State Committee for Scientific Research; Grant number: SPUB-M-COPERNICUS/P-05/DZ-30/99/2000; Grant sponsors: Instituto Universitario de Oncologia, Universidad de Oviedo, Asturias, Fondo de Investigacion Sanitaria (FIS) and Ciber de Epidemiologia y Salud Publica (CIBERESP), Swedish Council for Work Life Research and Swedish Environmental Protection Agency, Dutch Ministry of Health, Welfare and Sports, National Institute of Public Health and the Environment, and Europe Against Cancer Program, Roy Castle Foundation, and Intramural Research Program of the National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, Maryland.

Published
2018
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4. Lung Cancer Among Firefighters: Smoking-Adjusted Risk Estimates in a Pooled Analysis of Case-Control Studies

Author

Bigert, C, Gustavsson, P, Straif, K, Taeger, D, Pesch, B, Kendzia, B, Schuz, J, Stucker, I, Guida, F, Bruske, I, Wichmann, H E, Pesatori, A C, Landi, M T, Caporaso, N, Tse, L A, Yu, I T, Siemiatycki, J, Lavoue, J, Richiardi, L, Mirabelli, D, Simonato, L, Jockel, K H, Ahrens, W, Pohlabeln, H, Tardon, A, Zaridze, D, Field, J K, t Mannetje, A, Pearce, N, McLaughlin, J, Demers, P, Szeszenia-Dabrowska, N, Lissowska, J, Rudnai, P, Fabianova, E, Stanescu Dumitru, R, Bencko, V, Foretova, L, Janout, V, Boffetta, P, Peters, S, Vermeulen, R, Kromhout, H, Bruning, T, Olsson, A C, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, dIRAS RA-I&I RA, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, dIRAS RA-I&I RA, Bigert, C., Gustavsson, P., Straif, K., Taeger, D., Pesch, B., Kendzia, B., Schüz, J., Stücker, I., Guida, F., Brüske, I., Wichmann, H.-E., Pesatori, A.C., Landi, M.T., Caporaso, N., Tse, L.A., Yu, I.T.-S., Siemiatycki, J., Lavoué, J., Richiardi, L., Mirabelli, D., Simonato, L., Jöckel, K.-H., Ahrens, W., Pohlabeln, H., Tardón, A., Zaridze, D., Field, J.K., Mannetje, A., Pearce, N., McLaughlin, J., Demers, P., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Dumitru, R.S., Bencko, V., Foretova, L., Janout, V., Boffetta, P., Peters, S., Vermeulen, R., Kromhout, H., Brüning, T., and Olsson, A.C.

Subjects
Gerontology, Canada, China, Lung Neoplasms, Medizin, Logistic regression, Article, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Occupational Exposure, Odds Ratio, Medicine, Humans, 030212 general & internal medicine, Lung cancer, Cell specific, business.industry, Environmental and Occupational Health, Smoking, Public Health, Environmental and Occupational Health, Absolute risk reduction, Case-control study, Odds ratio, medicine.disease, 030210 environmental & occupational health, Europe, Occupational Diseases, Pooled analysis, Case-Control Studies, Firefighters, Lung cancer - firefighters, Public Health, Occupational exposure, business, Demography, New Zealand
Abstract

Objectives: The aim of this study was to explore lung cancer risk among firefighters, with adjustment for smoking. Methods: We used pooled information from the SYNERGY project including 14 case-control studies conducted in Europe, Canada, New Zealand, and China, with lifetime work histories and smoking habits for 14,748 cases of lung cancer and 17,543 controls. We estimated odds ratios by unconditional logistic regression with adjustment for smoking and having ever been employed in a job known to present an excess risk of lung cancer. Results: There was no increased lung cancer risk overall or by specific cell type among firefighters (n=190), neither before nor after smoking adjustment. We observed no significant exposure-response relationship in terms of work duration. Conclusions: We found no evidence of an excess lung cancer risk related to occupational exposure as a firefighter. Copyright © 2016 American College of Occupational and Environmental Medicine. Unauthorized reproduction of this article is prohibited.

Published
2016

5. Occupational prestige, social mobility and the association with lung cancer in men

Author

Behrens, Thomas, Groß, Is, Siemiatycki, Jack, Conway, David I., Olsson, Ann, Stücker, Isabelle, Guida, Florence, Jöckel, Karl-Heinz, Pohlabeln, Hermann, Ahrens, Wolfgang, Brüske, Irene, Wichmann, Heinz-Erich, Gustavsson, Per, Consonni, Dario, Merletti, Franco, Richiardi, Lorenzo, Simonato, Lorenzo, Fortes, Cristina, Parent, Marie-Elise, McLaughlin, John, Demers, Paul, Landi, Maria Teresa, Caporaso, Neil, Zaridze, David, Szeszenia-Dabrowska, Neonila, Rudnai, Peter, Lissowska, Jolanta, Fabianova, Eleonora, Tardón, Adonina, Field, John K, Dumitru, Rodica Stanescu, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Kromhout, Hans, Vermeulen, Roel, Boffetta, Paolo, Straif, Kurt, Schüz, Joachim, Hovanec, Jan, Kendzia, Benjamin, Pesch, Beate, Brüning, Thomas, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Montreal University Hospital Research Center (CRCHUM), Université de Montréal, University of Glasgow, Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation mondiale de la santé (OMS/WHO), The Institute of Environmental Medicine [Stockholm] (IMM), Karolinska Institutet [Stockholm], Centre de recherche en Épidémiologie et Santé des Populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ) - Université Paris-Sud 11 - Faculté de médecine (UP11 UFR Médecine) - Institut National de la Santé et de la Recherche Médicale (INSERM) - AP-HP Hôpital Paul Brousse [Paris], University of Duisburg-Essen [Germany], Leibniz Institute for Prevention Research and Epidemiology, University of Bremen, Helmholtz Zentrum München, Technical University Munich [Munich] (TUM), Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Unit of Cancer Epidemiology, Université de Turin - CERMS and Centre for Oncologic Prevention, University of Padova (ITALY), University of Padova, Istituto dermopatico dell'immacolata (IDI-IRCCS), Institut Armand Frappier (INRS-IAF), Institut National de la Recherche Scientifique [Québec] (INRS) - Réseau International des Instituts Pasteur - Institut Armand Frappier, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Occupational Cancer Research Centre, National Cancer Institute (NIH), Institute of Carcinogenesis, Russian Cancer Research Centre, The Nofer Institute of Occupational Medicine, National Institutes of Environmental Health Sciences, National Institutes of Health (NIH), The M Sklodowska-Curie Cancer Center and Institute of Oncology, Regional Authority of Public Health, CIBER de Epidemiología y Salud Pública (CIBERESP), University of Liverpool [Liverpool], University of Liverpool, National Institute of Public Health, Institute of Hygiene and Epidemiology, Charles University and General University Hospital - First Faculty of Medicine, Masaryk Memorial Cancer Institute and Medical Faculty of Masaryk University, Palacky University, Institute for Risk Assessment Sciences, Utrecht University [Utrecht], International Prevention Research Institute (IPRI), Icahn School of Medicine at Mount Sinai [New York], This work was supported by the German Social Accident Insurance (grant number FP 271). Grant sponsors of the individual studies were the Canadian Institutes of Health Research and Guzzo-SRC Chair in Environment and Cancer, the Fondation de France, the German Federal Ministry of Education, Science, Research, and Technology and the Ministry of Labour and Social Affairs, EC’s INCO-COPERNICUS Program, Polish State Committee for Science Research, Roy Castle Foundation, NIH/NCI/DCEG Intramural Research Program, Lombardy Region, INAIL and the European Union Nuclear Fission Safety Program, Italian Association for Cancer Research, Region Piedmont, Compagnia di San Paolo, Europe Against Cancer Program, the Swedish Council for Work Life Research and the Swedish EPA, the University of Oviedo, the European Regional Development Fund and the State Budget of the Czech Republic (RECAMO, CZ.1.05/2.1.00/03.0101), CIBERESP, and FISS-PI060604., LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-I&I RA, dIRAS RA-2, Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CR CHUM), Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM)-Université de Montréal (UdeM), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Universität Duisburg-Essen [Essen], Leibniz Institute for Prevention Research and Epidemiology - BIPS, Leibniz Association, Helmholtz Zentrum München = German Research Center for Environmental Health, Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Université de Turin-CERMS and Centre for Oncologic Prevention, Università degli Studi di Padova = University of Padua (Unipd), Institut National de la Recherche Scientifique [Québec] (INRS)-Réseau International des Instituts Pasteur (RIIP), Mount Sinai Hospital [Toronto, Canada] (MSH), National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH), Regional Authority of Public Health [Slovaquia] (RAPH), Ministry of Health of the Slovak Republic [Slovaquia], Charles University [Prague] (CU)-First Faculty of Medicine, Masaryk University [Brno] (MUNI), Department of Optics [Univ Palacký], Faculty of Science [Univ Palacký], Palacky University Olomouc-Palacky University Olomouc, Icahn School of Medicine at Mount Sinai [New York] (MSSM), Courcelles, Michel, Behrens, T., Groß, I., Siemiatycki, J., Conway, D.I., Olsson, A., Stücker, I., Guida, F., Jöckel, K.-H., Pohlabeln, H., Ahrens, W., Brüske, I., Wichmann, H.-E., Gustavsson, P., Consonni, D., Merletti, F., Richiardi, L., Simonato, L., Fortes, C., Parent, M.-E., McLaughlin, J., Demers, P., Landi, M.T., Caporaso, N., Zaridze, D., Szeszenia-Dabrowska, N., Rudnai, P., Lissowska, J., Fabianova, E., Tardón, A., Field, J.K., Dumitru, R.S., Bencko, V., Foretova, L., Janout, V., Kromhout, H., Vermeulen, R., Boffetta, P., Straif, K., Schüz, J., Hovanec, J., Kendzia, B., Pesch, B., Brüning, T., Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Helmholtz-Zentrum München (HZM), Universita degli Studi di Padova, and Charles University and General University Hospital-First Faculty of Medicine

Subjects
Adult, Male, Cancer Research, Occupational history, Lung Neoplasms, [SDV]Life Sciences [q-bio], socio-economic status, Socio-economic status, Medizin, Young Adult, Life Course, Occupational History, Synergy, Social Prestige, Socio-economic Status, Transitions, Social prestige, SYNERGY, Life course, Risk Factors, Occupational Exposure, Genetics, Odds Ratio, Humans, Occupational prestige, social mobility and the association with lung cancer in men, Aged, Aged, 80 and over, Smoking, Middle Aged, Social Mobility, [SDV] Life Sciences [q-bio], Oncology, Socioeconomic Factors, Case-Control Studies, transitions, occupational history, social prestige, Research Article
Abstract

BACKGROUND: The nature of the association between occupational social prestige, social mobility, and risk of lung cancer remains uncertain. Using data from the international pooled SYNERGY case–control study, we studied the association between lung cancer and the level of time-weighted average occupational social prestige as well as its lifetime trajectory. METHODS: We included 11,433 male cases and 14,147 male control subjects. Each job was translated into an occupational social prestige score by applying Treiman’s Standard International Occupational Prestige Scale (SIOPS). SIOPS scores were categorized as low, medium, and high prestige (reference). We calculated odds ratios (OR) with 95 % confidence intervals (CI), adjusting for study center, age, smoking, ever employment in a job with known lung carcinogen exposure, and education. Trajectories in SIOPS categories from first to last and first to longest job were defined as consistent, downward, or upward. We conducted several subgroup and sensitivity analyses to assess the robustness of our results. RESULTS: We observed increased lung cancer risk estimates for men with medium (OR = 1.23; 95 % CI 1.13–1.33) and low occupational prestige (OR = 1.44; 95 % CI 1.32–1.57). Although adjustment for smoking and education reduced the associations between occupational prestige and lung cancer, they did not explain the association entirely. Traditional occupational exposures reduced the associations only slightly. We observed small associations with downward prestige trajectories, with ORs of 1.13, 95 % CI 0.88–1.46 for high to low, and 1.24; 95 % CI 1.08–1.41 for medium to low trajectories. CONCLUSIONS: Our results indicate that occupational prestige is independently associated with lung cancer among men. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12885-016-2432-9) contains supplementary material, which is available to authorized users.

Published
2016
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6. Lung cancer risk among bricklayers in a pooled analysis of case-control studies

Author

Consonni, Dario, De Matteis, Sara, Pesatori, Angela C, Bertazzi, Pier Alberto, Olsson, Ann C, Kromhout, Hans, Peters, Susan, Vermeulen, Roel Ch, Pesch, Beate, Brüning, Thomas, Kendzia, Benjamin, Behrens, Thomas, Stücker, Isabelle, Guida, Florence, Wichmann, Heinz-Erich, Brüske, Irene, Landi, Maria Teresa, Caporaso, Neil E, Gustavsson, Per, Plato, Nils, Tse, Lap Ah, Yu, Ignatius Tak-Sun, Jöckel, Karl-Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Merletti, Franco, Richiardi, Lorenzo, Simonato, Lorenzo, Forastiere, Francesco, Siemiatycki, Jack, Parent, Marie-Élise, Tardón, Adonina, Boffetta, Paolo, Zaridze, David, Chen, Ying, Field, John K, 't Mannetje, Andrea, Pearce, Neil, McLaughlin, John, Demers, Paul, Lissowska, Jolanta, Szeszenia-Dabrowska, Neonila, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Rudnai, Peter, Fabiánová, Eleonóra, Stanescu Dumitru, Rodica, Bueno-de-Mesquita, Bas, Schüz, Joachim, Straif, Kurt, Risk Assessment, Infection & Immunity, dIRAS RA-2, dIRAS RA-I&I RA, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), LS IRAS EEPI GRA (Gezh.risico-analyse), Consonni, D. and De Matteis, S. and Pesatori, A.C. and Bertazzi, P.A. and Olsson, A.C. and Kromhout, H. and Peters, S. and Vermeulen, R.C.H. and Pesch, B. and Brüning, T. and Kendzia, B. and Behrens, T. and Stücker, I. and Guida, F. and Wichmann, H.-E. and Brüske, I. and Landi, M.T. and Caporaso, N.E. and Gustavsson, P. and Plato, N. and Tse, L.A. and Yu, I.T.-S. and Jöckel, K.-H. and Ahrens, W. and Pohlabeln, H. and Merletti, F. and Richiardi, L. and Simonato, L. and Forastiere, F. and Siemiatycki, J. and Parent, M.-É. and Tardón, A. and Boffetta, P. and Zaridze, D. and Chen, Y. and Field, J.K. and Mannetje, A. and Pearce, N. and McLaughlin, J. and Demers, P. and Lissowska, J. and Szeszenia-Dabrowska, N. and Bencko, V. and Foretova, L. and Janout, V. and Rudnai, P. and Fabiánová, E. and Dumitru, R.S. and Bueno-De-Mesquita, H.B. and Schüz, J. and Straif, K., Courcelles, Michel, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Università degli Studi di Milano = University of Milan (UNIMI), Imperial College London, Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), The Institute of Environmental Medicine [Stockholm] (IMM), Karolinska Institutet [Stockholm], Institute for Risk Assessment Sciences, Utrecht University [Utrecht], The University of Western Australia (UWA), Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH), The Chinese University of Hong Kong [Hong Kong], University Hospital Essen, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Leibniz Association, University of Bremen, Unit of Cancer Epidemiology, Université de Turin-CERMS and Centre for Oncologic Prevention, Università degli Studi di Padova = University of Padua (Unipd), Azienda Sanitaria Locale [ROMA] (ASL), Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM), Institut Armand Frappier (INRS-IAF), Institut National de la Recherche Scientifique [Québec] (INRS)-Réseau International des Instituts Pasteur (RIIP), CIBER de Epidemiología y Salud Pública (CIBERESP), International Prevention Research Institute (IPRI), Icahn School of Medicine at Mount Sinai [New York] (MSSM), Institute of Carcinogenesis, Russian Cancer Research Centre, Keele University [Keele], University of Liverpool, London School of Hygiene and Tropical Medicine (LSHTM), Samuel Lunenfeld Research Institute, Mount Sinai Hospital [Toronto, Canada] (MSH), Cancer Care Ontario, The M Sklodowska-Curie Cancer Center and Institute of Oncology, The Nofer Institute of Occupational Medicine, Institute of Hygiene and Epidemiology, Charles University [Prague] (CU)-First Faculty of Medicine, Masaryk University [Brno] (MUNI), Department of Optics [Univ Palacký], Faculty of Science [Univ Palacký], Palacky University Olomouc-Palacky University Olomouc, National Institutes of Environmental Health Sciences, Regional Authority of Public Health [Slovaquia] (RAPH), Ministry of Health of the Slovak Republic [Slovaquia], Institute of Public Health, National Institute for Public Health and the Environment [Bilthoven] (RIVM), Grant sponsor: German Social Accident Insurance (DGUV), Grant number: FP 271, Grant sponsors: Canadian Institutes for Health Researchand Guzzo-SRC Chair in Environm ent and Cancer, National Cancer Institute of Canada, Canadian Cancer Society, Occupational Cancer ResearchCentre, Workplace Safety and Insuranc e Boar d, Canadian Cancer Society, and Cancer Care Ontario, Grant sponsor: European Commission’s INCO Copernicus program, Grant number: IC15-CT96-0313, Grant sponsor: European Union Nuclear Fission Safety Program, Grant number:F14P-CT96-0055, Grant sponsors: French Agency of Health Security (ANSES), Fondation de France, French National Research Agency (ANR),National Institute of Cancer (INCA), Fondation pour la Recherche Medicale, French Institute for Public Health Surveillance (InVS), Health Ministry (DGS), Organization for the Research on Cancer (ARC), and French Ministry of work, solidarity, and public function (DGT), Grant sponsor: Federal Ministry of Education, Science, Research, and Technology, Grant number: 01 HK 173/0), Grant sponsor: Federal Ministry of Science, Grant number:01 HK 546/8, Grant sponsor: Ministry of Labour and Social Affairs, Grant number: IIIb7-27/13, Grant sponsor: Research Grants Council of the Hong Kong Special Administrative Region, China, Grant number: CUHK4460/03M, Grant sponsors: Environmental Epidemiology Program of the Lombardy Region, INAIL, Italian Association for Cancer Research, Region Piedmont, Compagnia di San Paolo, Lazio Region, Health Research Council of New Zealand, New Zealand Department of Labour, Lottery Health Research, Cancer Society of New Zealand, Grant sponsor: Polish State Committee for Scientific Research, Grant number: SPUB-M-COPERNICUS/P-05/DZ-30/99/2000, Grant sponsors: Instituto Universitario de Oncologia, Universidad de Oviedo, Asturias, Fondo de Investigacion Sanitaria (FIS) and Ciber de Epidemiologia y Salud Publica (CIBERESP), Swedish Council for Work Life Research and Swedish Environmental Protection Agency, Dutch Ministry of Health, Welfare and Sports, National Institute of Public Health and the Environment, and Europe Against Cancer Program, Roy Castle Foundation, and Intramural Research Program of the National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, Maryland, Risk Assessment, Infection & Immunity, dIRAS RA-2, dIRAS RA-I&I RA, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), LS IRAS EEPI GRA (Gezh.risico-analyse), Università degli Studi di Milano [Milano] (UNIMI), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Universita degli Studi di Padova, Charles University and General University Hospital-First Faculty of Medicine, and Masaryk Memorial Cancer Institute and Medical Faculty of Masaryk University

Subjects
Male, Epidemiology, control studies, cancer risk, bricklayer, middle aged, occupation, CARCINOGENS, blue collar worker, POPULATION, comparative study, education.field_of_study, MESH: Middle Aged, risk assessment, WORKERS, MEN, MESH: Carcinoma, Squamous Cell, clinical trial, MESH: Follow-Up Studies, Prognosis, MESH: Case-Control Studies, 3. Good health, Occupational Diseases, [SDV] Life Sciences [q-bio], OCCUPATIONAL-EXPOSURE, hospital based case control study, Oncology, priority journal, risk factor, Adenocarcinoma, Carcinoma, Squamous Cell, case, Human, MESH: Occupational Diseases, medicine.medical_specialty, national cancer institute of, additional supporting information may, case–control studies, employment statu, MESH: Prognosis, Article, Follow-Up Studie, MESH: International Agencies, [SDV.CAN] Life Sciences [q-bio]/Cancer, carcinogen, adult, Humans, [SDV.EE.SANT] Life Sciences [q-bio]/Ecology, environment/Health, research and guzzo-src chair, education, CRYSTALLINE SILICA DUST, fp 271, Science & Technology, MESH: Humans, Occupational health, MORTALITY, health care facility, Construction Industry, Case-control study, bricklayers, Odds ratio, case control study, medicine.disease, dguv, lung adenocarcinoma, major clinical study, Lung neoplasm, occupational hazard, MESH: Lung Neoplasms, Occupational Disease, occupational cancer, multicenter study, age, Relative risk, small cell lung cancer, Occupational medicine, MESH: Female, population research, Cancer Research, online version of this, [SDV]Life Sciences [q-bio], canada, Medizin, medicine.disease_cause, MESH: Occupational Exposure, grant number, Risk Factors, MESH: Risk Factors, Carcinoma, Small Cell, Medicine (all), international cooperation, grant sponsor, article, canadian institutes for health, MESH: Carcinoma, Small Cell, be found in the, MESH: Construction Industry, female, NORDIC COUNTRIES, International Agencie, canadian cancer society, epidemiology, grant sponsors, Gustavsson, in environment and cancer, Case-Control Studie, Life Sciences & Biomedicine, lifespan, prognosi, Population, UNITED-STATES, [SDV.CAN]Life Sciences [q-bio]/Cancer, lung neoplasms, Asbestos, smoking, building industry, occupational health, Internal medicine, Occupational Exposure, medicine, follow up, controlled study, occupational, Lung cancer, population based case control study, Plato, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, adenocarcinoma, business.industry, case-control studies, Risk Factor, Carcinoma, MESH: Adenocarcinoma, International Agencies, Small Cell, Confidence interval, MESH: Male, human tissue, Surgery, lung cancer, german social accident insurance, Squamous Cell, Bricklayers, Case-control studies, Lung neoplasms, Adenocarcinoma, Case-Control Studies, Female, Follow-Up Studies, Lung Neoplasms, Middle Aged, business, CONSTRUCTION-INDUSTRY, squamous cell lung carcinoma
Abstract

Bricklayers may be exposed to several lung carcinogens, including crystalline silica and asbestos. Previous studies that analyzed lung cancer risk among these workers had several study design limitations. We examined lung cancer risk among bricklayers within SYNERGY, a large international pooled analysis of case–control studies on lung cancer and the joint effects of occupational carcinogens. For men ever employed as bricklayers we estimated odds ratios (OR) and 95% confidence intervals (CI) adjusted for study center, age, lifetime smoking history and employment in occupations with exposures to known or suspected lung carcinogens. Among 15,608 cases and 18,531 controls, there were 695 cases and 469 controls who had ever worked as bricklayers (OR: 1.47; 95% CI: 1.28–1.68). In studies using population controls the OR was 1.55 (95% CI: 1.32–1.81, 540/349 cases/controls), while it was 1.24 (95% CI: 0.93–1.64, 155/120 cases/controls) in hospital-based studies. There was a clear positive trend with length of employment (p < 0.001). The relative risk was higher for squamous (OR: 1.68, 95% CI: 1.42–1.98, 309 cases) and small cell carcinomas (OR: 1.78, 95% CI: 1.44–2.20, 140 cases), than for adenocarcinoma (OR: 1.17, 95% CI: 0.95–1.43, 150 cases) (p-homogeneity: 0.0007). ORs were still elevated after additional adjustment for education and in analyses using blue collar workers as referents. This study provided robust evidence of increased lung cancer risk in bricklayers. Although non-causal explanations cannot be completely ruled out, the association is plausible in view of the potential for exposure to several carcinogens, notably crystalline silica and to a lesser extent asbestos. WHAT'S NEW?: In their work, bricklayers can be exposed to various airborne carcinogens, including crystalline silica and asbestos. Previous studies of cancer risk have not accounted for full employment history or smoking status, and failed to establish a firm relationship between bricklaying and lung cancer. In this study, the authors used data from the largest collection of case-control studies on lung cancer with complete occupational and smoking history existing today, the SYNERGY project. They found clear evidence that lung cancer risk increases in proportion to the length of time spent working as a bricklayer, paving the way for better protection and compensation for those in this occupation.

Published
2015
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7. Is previous respiratory disease a risk factor for lung cancer?

Author

Denholm, Rachel, Schüz, Joachim, Straif, Kurt, Stücker, Isabelle, Jöckel, Karl-Heinz, Brenner, Darren R, De Matteis, Sara, Boffetta, Paolo, Guida, Florence, Brüske, Irene, Wichmann, Heinz-Erich, Landi, Maria Teresa, Caporaso, Neil, Siemiatycki, Jack, Ahrens, Wolfgang, Pohlabeln, Hermann, Zaridze, David, Field, John K, McLaughlin, John, Demers, Paul, Szeszenia-Dabrowska, Neonila, Lissowska, Jolanta, Rudnai, Peter, Fabianova, Eleonora, Dumitru, Rodica Stanescu, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Kendzia, Benjamin, Peters, Susan, Behrens, Thomas, Vermeulen, Roel, Brüning, Thomas, Kromhout, Hans, Olsson, Ann, Risk Assessment of Toxic and Immunomodulatory Agents, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), LS IRAS EEPI GRA (Gezh.risico-analyse), IRAS RATIA2, IRAS RATIA-SIB, Risk Assessment of Toxic and Immunomodulatory Agents, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), LS IRAS EEPI GRA (Gezh.risico-analyse), IRAS RATIA2, IRAS RATIA-SIB, Coppens, Kim, Denholm, R., Schüz, J., Straif, K., Stücker, I., Jöckel, K.-H., Brenner, D.R., De Matteis, S., Boffetta, P., Guida, F., Brüske, I., Wichmann, H.-E., Landi, M.T., Caporaso, N., Siemiatycki, J., Ahrens, W., Pohlabeln, H., Zaridze, D., Field, J.K., McLaughlin, J., Demers, P., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Dumitru, R.S., Bencko, V., Foretova, L., Janout, V., Kendzia, B., Peters, S., Behrens, T., Vermeulen, R., Brüning, T., Kromhout, H., and Olsson, A.C.

Subjects
Male, Chronic bronchitis, Lung Neoplasms, Medizin, Critical Care and Intensive Care Medicine, Case–control Study, Data Pooling, Epidemiologic Study, Lung Neoplasm, Pulmonary Disease, Risk Factors, Odds Ratio, Prevalence, Epidemiologic study, ComputingMilieux_MISCELLANEOUS, pulmonary disease, Respiratory disease, respiratory system, Middle Aged, Bronchitis, Chronic, Europe, Pulmonary Emphysema, Female, Original Article, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Canada, Case–control study, Data pooling, Internal medicine, medicine, Humans, Risk factor, Intensive care medicine, Lung cancer, Asthma, business.industry, Case-control study, case–control study, Odds ratio, Pneumonia, medicine.disease, Lung neoplasm, lung neoplasm, respiratory tract diseases, Logistic Models, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, data pooling, Case-Control Studies, epidemiologic study, Multivariate Analysis, Pulmonary disease, business
Abstract

Rationale: Previous respiratory diseases have been associated with increased risk of lung cancer. Respiratory conditions often co-occur and few studies have investigated multiple conditions simultaneously. Objectives: Investigate lung cancer risk associated with chronic bronchitis, emphysema, tuberculosis, pneumonia, and asthma. Methods: The SYNERGY project pooled information on previous respiratory diseases from 12,739 case subjects and 14,945 control subjects from 7 case-control studies conducted in Europe and Canada. Multivariate logistic regression models were used to investigate the relationship between individual diseases adjusting for co-occurring conditions, and patterns of respiratory disease diagnoses and lung cancer. Analyses were stratified by sex, and adjusted for age, center, ever-employed in a high-risk occupation, education, smoking status, cigarette pack-years, and time since quitting smoking. Measurements and Main Results: Chronic bronchitis and emphysema were positively associated with lung cancer, after accounting for other respiratory diseases and smoking (e.g., in men: odds ratio [OR], 1.33; 95% confidence interval [CI], 1.20-1.48 and OR, 1.50; 95% CI, 1.21-1.87, respectively). A positive relationship was observed between lung cancer and pneumonia diagnosed 2 years or less before lung cancer (OR, 3.31; 95% CI, 2.33-4.70 for men), but not longer. Co-occurrence of chronic bronchitis and emphysema and/or pneumonia had a stronger positive association with lung cancer than chronic bronchitis "only." Asthma had an inverse association with lung cancer, the association being stronger with an asthma diagnosis 5 years or more before lung cancer compared with shorter. Conclusions: Findings from this large international case-control consortium indicate that after accounting for co-occurring respiratory diseases, chronic bronchitis and emphysema continue to have a positive association with lung cancer. Copyright © 2014 by the American Thoracic Society.

Published
2014

8. Lung cancer risk among bakers, pastry cooks and confectionary makers: the SYNERGY study

Author

Maria Teresa Landi, Per Gustavsson, John R. McLaughlin, Hans Erich Wichmann, Tabea Treppmann, David Zaridze, Florence Guida, Kurt Straif, Roel Vermeulen, Nils Plato, Eleonora Fabianova, Lap Ah Tse, Marie-Élise Parent, Vladimir Janout, Peter Rudnai, Vladimir Bencko, Neil E. Caporaso, Ann Olsson, Neil Pearce, Adonina Tardón, Paolo Boffetta, Isabelle Stücker, Lorenzo Richiardi, Dario Consonni, Rodica Stanescu Dumitru, Andrea 't Mannetje, Thomas Behrens, Neonila Szeszenia-Dabrowska, Karl-Heinz Jöckel, Franco Merletti, Ignatius Tak-sun Yu, Bas Bueno-de-Mesquita, Dario Mirabelli, Simone Benhamou, Jolanta Lissowska, Hermann Pohlabeln, Hans Kromhout, Susan Peters, Lenka Foretova, John K. Field, Joachim Schüz, Irene Brüske, Lorenzo Simonato, Thomas Brüning, Wolfgang Ahrens, Beate Pesch, Benjamin Kendzia, Jack Siemiatycki, Paul A. Demers, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), The Institute of Environmental Medicine [Stockholm] (IMM), Karolinska Institutet [Stockholm], Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Leibniz Association, Institute for Statistics, University of Bremen, Institute of Epidemiology I, German Research Center for Environmental Health-Helmholtz-Zentrum München (HZM), Cancer Epidemiology Unit, Université de Turin, Department of Environmental Medicine and Public Health, Universita degli Studi di Padova, Institute of Carcinogenesis, Russian Academy of Medical Sciences, The Nofer Institute of Occupational Medicine, National Institute of Environmental Health, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Regional Authority of Public Health [Slovaquia] (RAPH), Ministry of Health of the Slovak Republic [Slovaquia], Molecular Epidemiology of Cancer Unit, CIBER de Epidemiología y Salud Pública (CIBERESP), Roy Castle Lung Cancer Research Programme, University of Liverpool, National Institute of Public Health [Romania] (INSP), Institute of Hygiene and Epidemiology, Charles University [Prague] (CU)-1st Faculty of Medicine, Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute (RECAMO), Faculty of Medicine, Palacky University Olomouc, Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CR CHUM), Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM)-Université de Montréal (UdeM), Institut Armand Frappier (INRS-IAF), Réseau International des Instituts Pasteur (RIIP)-Institut National de la Recherche Scientifique [Québec] (INRS), Cancer Care Ontario, Occupational Cancer Research Centre, National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH), Division of Environmental Epidemiology, Utrecht University [Utrecht]-Institute of Risk Assessment Sciences, Western Australian Institute for Medical Research, The University of Western Australia (UWA), Variabilité Génétique et Maladies Humaines, Institut Universitaire d'Hématologie (IUH), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), University Paris-Sud, Unit of Epidemiology, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, National Institute for Public Health and the Environment [Bilthoven] (RIVM), Centre for Public Health Research, Faculty of Epidemiology and Population Health [London], London School of Hygiene and Tropical Medicine (LSHTM), Division of Occupational and Environmental Health, JC School of Public Health and Primary Care, The Chinese University of Hong Kong [Hong Kong]-The Chinese University of Hong Kong [Hong Kong], The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai [New York] (MSSM), International Prevention Research Institute (IPRI), This study was supported by the German Social Accident Insurance, grant FP 271. Grant sponsors of the individual studies were the Canadian Institutes of Health Research and Guzzo-SRC Chair in Environment and Cancer, the Fondation de France, the German Federal Ministry of Education, Science, Research, and Technology and the Ministry of Labour and Social Affairs, the EC's INCO-COPERNICUS Program, the Polish State Committee for Science Research, the Roy Castle Foundation, the NIH/NCI/DCEG Intramural Research Program, Lombardy Region, INAIL and the European Union Nuclear Fission Safety Program, the Italian Association for Cancer Research, Region Piedmont, the Compagnia di San Paolo, the Europe Against Cancer Program, the Swedish Council for Work Life Research and the Swedish EPA, the University of Oviedo, the European Regional Development Fund and the State Budget of the Czech Republic (RECAMO, CZ.1.05/2.1.00/03.0101), CIBERESP and FISS-PI060604., Behrens, T., Kendzia, B., Treppmann, T., Olsson, A., Jöckel, K.-H., Gustavsson, P., Pohlabeln, H., Ahrens, W., Brüske, I., Wichmann, H.-E., Merletti, F., Mirabelli, D., Richiardi, L., Simonato, L., Zaridze, D., Szeszenia-Dabrowska, N., Rudnai, P., Lissowska, J., Fabianova, E., Tardón, A., Field, J., Dumitru, R.S., Bencko, V., Foretova, L., Janout, V., Siemiatycki, J., Parent, M.-E., McLaughlin, J., Demers, P., Landi, M.T., Caporaso, N., Kromhout, H., Vermeulen, R., Peters, S., Benhamou, S., Stücker, I., Guida, F., Consonni, D., Bueno-de-Mesquita, B., Mannetje, A.'., Pearce, N., Tse, L.A., Yu, I.T.-S., Plato, N., Boffetta, P., Straif, K., Schüz, J., Pesch, B., and Brüning, T.

Subjects
Male, xposure to occupational lung carcinogens, Lung Neoplasms, [SDV]Life Sciences [q-bio], Medizin, MESH: Logistic Models, Logistic regression, MESH: Occupational Exposure, baker, 0302 clinical medicine, Risk Factors, MESH: Risk Factors, Odds Ratio, Food Industry, smoking behaviour, baking-related occupation, Control subjects, 030210 environmental & occupational health, MESH: Case-Control Studies, MESH: Food Industry, Occupational Diseases, 030220 oncology & carcinogenesis, Smoking status, Female, MESH: Occupational Diseases, medicine.medical_specialty, Article, 03 medical and health sciences, Occupational Exposure, medicine, Humans, Occupations, Lung cancer, MESH: Occupations, MESH: Humans, business.industry, Public Health, Environmental and Occupational Health, Case-control study, Odds ratio, medicine.disease, MESH: Male, MESH: Odds Ratio, Surgery, MESH: Lung Neoplasms, lung cancer, Increased risk, Logistic Models, Case-Control Studies, business, MESH: Female, Demography
Abstract

Introduction Some studies have suggested increased lung cancer risks among bakers, however the results overall were inconsistent. The authors studied lung cancer risks among bakers and baking-related occupations in the SYNERGY pooled case–control database from 16 countries. Methods Occupation in a baking-related job was identified from the subjects’ job histories. ORs adjusted for log(age), study centre, smoking behaviour and ever employment in a job with known exposure to occupational lung carcinogens were calculated by unconditional logistic regression. Findings were stratified by sex, histological subtype of lung cancer and smoking status. Results 19 366 cases (15 606 men) and 23 670 control subjects (18 528 men) were included. 473 cases (415 men, 58 women) and 501 controls (437 men, 64 women) had ever worked in baking or a related job. We did not observe an increased risk for men in baking (OR 1.01; 95% CI 0.86 to 1.18). No linear trends were observed for duration of employment. Some results suggested increased lung cancer risks for women, for example, for working as a baker for >30 years and in never-smokers, but after exclusion of one study these increased risks disappeared. Discussion The findings from this study do not suggest increased lung cancer risks in baking-related professions.

Published
2013
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9. Lung cancer risk among hairdressers : a pooled analysis of case-control studies conducted between 1985 and 2010

Author

Adonina Tardón, Paul A. Demers, David Zaridze, Neil E. Caporaso, Cristina Fortes, Ann Olsson, Benjamin Kendzia, Per Gustavsson, Dario Mirabelli, Jack Siemiatycki, Isabelle Stücker, Jelle Vlaanderen, Nils Plato, Lap Ah Tse, Thomas Brüning, Bas Bueno-de-Mesquita, Vladimir Janout, Lesley Richardson, Susan Peters, Irene Brüske, Roel Vermeulen, Vladimir Bencko, Lenka Foretova, Lorenzo Richiardi, Kurt Straif, Jolanta Lissowska, Andrea 't Mannetje, Beate Pesch, Peter Rudnai, Hermann Pohlabeln, Neil Pearce, Michael W. Marcus, Heinz Erich Wichmann, Joachim Schüz, Eleonora Fabianova, Rodica Stanescu Dumitru, John R. McLaughlin, Karl-Heinz Jöckel, Ignatius Tak-sun Yu, Florence Guida, Dario Consonni, Lorenzo Simonato, Wolfgang Ahrens, Thomas Behrens, Neonila Szeszenia-Dabrowska, Paolo Boffetta, Yiwen Xu, Hans Kromhout, Maria Teresa Landi, Olsson, A.C., Xu, Y., Schüz, J., Vlaanderen, J., Kromhout, H., Vermeulen, R., Peters, S., Stücker, I., Guida, F., Brüske, I., Wichmann, H.-E., Consonni, D., Landi, M.T., Caporaso, N., Tse, L.A., Yu, I.T.-S., Siemiatycki, J., Richardson, L., Mirabelli, D., Richiardi, L., Simonato, L., Gustavsson, P., Plato, N., Jöckel, K.-H., Ahrens, W., Pohlabeln, H., Tardón, A., Zaridze, D., Marcus, M.W., Mannetje, A., Pearce, N., McLaughlin, J., Demers, P., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Dumitru, R.S., Bencko, V., Foretova, L., Janout, V., Boffetta, P., Fortes, C., Bueno-De-Mesquita, B., Kendzia, B., Behrens, T., Pesch, B., Brüning, T., and Straif, K.

Subjects
Male, medicine.medical_specialty, Lung Neoplasms, Time Factors, Epidemiology, Population, Medizin, Barbering, 03 medical and health sciences, 0302 clinical medicine, Sex Factors, Risk Factors, Internal medicine, Occupational Exposure, Odds Ratio, Medicine, Humans, education, Lung cancer, education.field_of_study, business.industry, Confounding, Smoking, Case-control study, Odds ratio, medicine.disease, 030210 environmental & occupational health, Confidence interval, 3. Good health, Surgery, Occupational Diseases, case-control studies, hair bleaching agents, hair color, lung neoplasms, occupational exposure, 030220 oncology & carcinogenesis, Case-Control Studies, Adenocarcinoma, Female, business, Systematic Reviews and Meta- and Pooled Analyses, Cohort study
Abstract

Increased lung cancer risks among hairdressers were observed in large registry-based cohort studies from Scandinavia, but these studies could not adjust for smoking. Our objective was to evaluate the lung cancer risk among hairdressers while adjusting for smoking and other confounders in a pooled database of 16 case-control studies conducted in Europe, Canada, China, and New Zealand between 1985 and 2010 (the Pooled Analysis of Case-Control Studies on the Joint Effects of Occupational Carcinogens in the Development of Lung Cancer). Lifetime occupational and smoking information was collected through interviews with 19,369 cases of lung cancer and 23,674 matched population or hospital controls. Overall, 170 cases and 167 controls had ever worked as hairdresser or barber. The odds ratios for lung cancer in women were 1.65 (95% confidence interval (CI): 1.16, 2.35) without adjustment for smoking and 1.12 (95% CI: 0.75, 1.68) with adjustment for smoking; however, women employed before 1954 also experienced an increased lung cancer risk after adjustment for smoking (odds ratio = 2.66, 95% CI: 1.09, 6.47). The odds ratios in male hairdressers/barbers were generally not elevated, except for an increased odds ratio for adenocarcinoma in long-term barbers (odds ratio = 2.20, 95% CI: 1.02, 4.77). Our results suggest that the increased lung cancer risks among hairdressers are due to their smoking behavior; single elevated risk estimates should be interpreted with caution and need replication in other studies. © The Author 2013.

Published
2013

10. Cigarette smoking and lung cancer-relative risk estimates for the major histological types from a pooled analysis of case-control studies

Author

Kurt Straif, Rodica Stanescu Dumitru, Lorenzo Simonato, Cristina Fortes, Adrian Cassidy, Karl-Heinz Jöckel, Lorenzo Richiardi, Vladimir Janout, Georg Johnen, Lenka Foretova, Irene Brüske, Vladimir Bencko, Jolanta Lissowska, Franco Merletti, Peter Rudnai, Benjamin Kendzia, Beate Pesch, Jack Siemiatycki, Charles M. Rudin, Heinz Erich Wichmann, Dario Consonni, David Zaridze, Marie-Élise Parent, Neonila Szeszenia-Dabrowska, Per Gustavsson, Wolfgang Ahrens, Isabelle M. Gross, Paul Brennan, Hermann Pohlabeln, Eleonora Fabianova, Neil E. Caporaso, Ann Olsson, Isabelle Stücker, Thomas Brüning, Paolo Boffetta, Maria Teresa Landi, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), The Institute of Environmental Medicine [Stockholm] (IMM), Karolinska Institutet [Stockholm], Institute for Medical Informatics, Biometry, and Epidemiology, University Hospital of Essen, Bremen Institute for Prevention Research and Social Medicine, University of Bremen, International Agency for Cancer Research (IACR), Institute of Epidemiology, Helmholtz-Zentrum München (HZM), Cancer Epidemiology Unit, Université de Turin-CPO-Piemonte, Department of Environmental Medicine and Public Health, Universita degli Studi di Padova, Clinical Epidemiology Unit, IDI-IRCCS, Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CR CHUM), Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM)-Université de Montréal (UdeM), Institut Armand Frappier (INRS-IAF), Institut National de la Recherche Scientifique [Québec] (INRS)-Réseau International des Instituts Pasteur (RIIP), Unit of Epidemiology, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico-Ospedale Maggiore Policlinico, Division of Cancer Epidemiology and Genetics, National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH)-National Institutes of Health [Bethesda] (NIH), Institute of Carcinogenesis, Russian Cancer Research Centre, Roy Castle Lung Cancer Research Programme, University of Liverpool-Cancer Research Centre, The Nofer Institute of Occupational Medicine, National Institute of Environment Health, The M Sklodowska-Curie Cancer Center, Institute of Oncology, Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Occupational Health, Regional Authority of Public Health-Specialized State Health Institute, National Institute of Public Health [Romania] (INSP), Institute of Hygiene and Epidemiology, Charles University [Prague] (CU)-1st Faculty of Medicine, Masaryk Memorial Cancer Institute, Masaryk Memorial Cancer Institute (RECAMO), Department of Preventive Medicine, Faculty of Medicine-Palacky University Olomouc, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine [Baltimore], The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai [New York] (MSSM), International Prevention Research Institute (IPRI), Grant sponsor: German Social Accident Insurance, Grant number: FP 271, Grant sponsors: Canadian Institutes of Health Research and Guzzo-SRC Chair in Environment and Cancer, the Fondation de France, the German Federal Ministry of Education, Science, Research, and Technology and the Ministry of Labour and Social Affairs, EC's INCO-COPERNICUS Program, Polish State Committee for Science Research, Roy Castle Foundation, NIH/NCI/DCEG Intramural Research Program, Lombardy Region, INAIL and the European Union Nuclear Fission Safety Program, Italian Association for Cancer Research, Region Piedmont, Compagnia di San Paolo, Europe Against Cancer Program, the Swedish Council for Work Life Research and the Swedish EPA, Pesch, B., Kendzia, B., Gustavsson, P., Jöckel, K.-H., Johnen, G., Pohlabeln, H., Olsson, A., Ahrens, W., Gross, I.M., Brüske, I., Wichmann, H.-E., Merletti, F., Richiardi, L., Simonato, L., Fortes, C., Siemiatycki, J., Parent, M.-E., Consonni, D., Landi, M.T., Caporaso, N., Zaridze, D., Cassidy, A., Szeszenia-Dabrowska, N., Rudnai, P., Lissowska, J., Stücker, I., Fabianova, E., Dumitru, R.S., Bencko, V., Foretova, L., Janout, V., Rudin, C.M., Brennan, P., Boffetta, P., Straif, K., and Brüning, T.

Subjects
Male, Oncology, Cancer Research, Lung Neoplasms, Medizin, cigarette smoking, Tobacco smoke, 0302 clinical medicine, Prevalence, Child, 0303 health sciences, education.field_of_study, relative risk characterization, Smoking, Middle Aged, Prognosis, 3. Good health, Europe, 030220 oncology & carcinogenesis, Carcinoma, Squamous Cell, Adenocarcinoma, Female, tobacco smoke, Adult, Risk, Canada, medicine.medical_specialty, Adolescent, Population, [SDV.CAN]Life Sciences [q-bio]/Cancer, Article, Young Adult, 03 medical and health sciences, stem cells, Internal medicine, medicine, Humans, education, Lung cancer, Neoplasm Staging, 030304 developmental biology, Gynecology, cigarette smoking, lung cancer, relative risk characterization, tobacco smoke, stem cells, business.industry, Case-control study, Odds ratio, medicine.disease, Small Cell Lung Carcinoma, Confidence interval, respiratory tract diseases, lung cancer, lung cancer, cigarette smoking, Case-Control Studies, Relative risk, business
Abstract

International audience; Lung cancer is mainly caused by smoking, but the quantitative relations between smoking and histologic subtypes of lung cancer remain inconclusive. By using one of the largest lung cancer datasets ever assembled, we explored the impact of smoking on risks of the major cell types of lung cancer. This pooled analysis included 13,169 cases and 16,010 controls from Europe and Canada. Studies with population controls comprised 66.5% of the subjects. Adenocarcinoma (AdCa) was the most prevalent subtype in never smokers and in women. Squamous cell carcinoma (SqCC) predominated in male smokers. Age-adjusted odds ratios (ORs) were estimated with logistic regression. ORs were elevated for all metrics of exposure to cigarette smoke and were higher for SqCC and small cell lung cancer (SCLC) than for AdCa. Current male smokers with an average daily dose of >30 cigarettes had ORs of 103.5 (95% confidence interval (CI): 74.8-143.2) for SqCC, 111.3 (95% CI: 69.8-177.5) for SCLC and 21.9 (95% CI: 16.6-29.0) for AdCa. In women, the corresponding ORs were 62.7 (95% CI: 31.5-124.6), 108.6 (95% CI: 50.7-232.8) and 16.8 (95% CI: 9.2-30.6), respectively. Although ORs started to decline soon after quitting, they did not fully return to the baseline risk of never smokers even 35 years after cessation. The major result that smoking exerted a steeper risk gradient on SqCC and SCLC than on AdCa is in line with previous population data and biological understanding of lung cancer development.

Published
2012
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11. Exposure to diesel motor exhaust and lung cancer risk in a pooled analysis from case-control studies in Europe and Canada

Author

Paul Brennan, Dario Consonni, Vladimir Bencko, Eleonora Fabianova, Dario Mirabelli, Francesco Forastiere, Simone Benhamou, Bas Bueno-de-Mesquita, Heinz Erich Wichmann, Benjamin Kendzia, Jack Siemiatycki, Susan Peters, Neil E. Caporaso, Nils Plato, Per Gustavsson, Lenka Foretova, Thomas Brüning, Ann Olsson, Roel Vermeulen, Paolo Boffetta, Isabelle Stücker, Javier Pintos, Lorenzo Richiardi, David Zaridze, Jolanta Lissowska, Rodica Stanescu Dumitru, Hans Kromhout, Franco Merletti, Wolfgang Ahrens, Peter Rudnai, Maria Teresa Landi, Karl-Heinz Jöckel, Neonila Szeszenia-Dabrowska, Irene Brüske, Beate Pesch, Adrian Cassidy, Vladimir Janout, Kurt Straif, Hermann Pohlabeln, Isabelle M. Gross, Olsson, A.C., Gustavsson, P., Kromhout, H., Peters, S., Vermeulen, R., Brüske, I., Pesch, B., Siemiatycki, J., Pintos, J., Brüning, T., Cassidy, A., Wichmann, H.-E., Consonni, D., Landi, M.T., Caporaso, N., Plato, N., Merletti, F., Mirabelli, D., Richiardi, L., Jöckel, K.-H., Ahrens, W., Pohlabeln, H., Lissowska, J., Szeszenia-Dabrowska, N., Zaridze, D., Stücker, I., Benhamou, S., Bencko, V., Foretova, L., Janout, V., Rudnai, P., Fabianova, E., Dumitru, R.S., Gross, I.M., Kendzia, B., Forastiere, F., Bueno-de-Mesquita, B., Brennan, P., Boffetta, P., and Straif, K.

Subjects
Pulmonary and Respiratory Medicine, Adult, Male, Canada, Lung Neoplasms, Time Factors, Job-exposure matrix, Population, Medizin, Critical Care and Intensive Care Medicine, Logistic regression, complex mixtures, Risk Assessment, Severity of Illness Index, Occupational safety and health, Age Distribution, Reference Values, Environmental health, vehicle emissions, medicine, Confidence Intervals, Odds Ratio, Humans, Sex Distribution, Lung cancer, education, Occupational Health, Aged, education.field_of_study, business.industry, Incidence, Smoking, Case-control study, Odds ratio, occupational exposure, Middle Aged, medicine.disease, Survival Analysis, lung neoplasm, Europe, Logistic Models, Case-Control Studies, Carcinogens, epidemiologic studie, Female, Risk assessment, business, epidemiologic studies
Abstract

Rationale: Diesel motor exhaust is classified by the International Agency for Research on Cancer as probably carcinogenic to humans. The epidemiologic evidence is evaluated as limited because most studies lack adequate control for potential confounders and only a few studies have reported on exposure-response relationships. Objectives: Investigate lung cancer risk associated with occupational exposure to diesel motor exhaust, while controlling for potential confounders. Methods: The SYNERGY project pooled information on lifetime work histories and tobacco smoking from13,304 cases and 16,282 controls from 11 case-control studies conducted in Europe and Canada. A general population job exposure matrix based on ISCO-68 occupational codes, assigning no, low, or high exposure to diesel motor exhaust, was applied to determine level of exposure. Measurements and Main Results: Odds ratios of lung cancer and 95% confidence intervals were estimated by unconditional logistic regression, adjusted for age, sex, study, ever-employment in an occupation with established lung cancer risk, cigarette pack-years, and time-since-quitting smoking. Cumulative diesel exposure was associated with an increased lung cancer risk highest quartile versus unexposed (odds ratio 1.31; 95%confidence interval, 1.19-1.43), and a significant exposure-response relationship (P value < 0.01). Corresponding effect estimates were similar in workers never employed in occupations with established lung cancer risk, and in women and neversmokers, although not statistically significant. Conclusions: Our results show a consistent association between occupational exposure to diesel motor exhaust and increased risk of lung cancer. This association is unlikely explained by bias or confounding, which we addressed by adjusted models ands ubgroup analyses. Copyright © 2011 American Thoracic Society.

Published
2011

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