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3. Assessment of lmage-guided Programming (IGP) on Bilateral STN and GPi Deep Brain Stimulation Programming Time (P1-3.003)

Author

Aldred, Jason, primary, Zesiewicz, Theresa, additional, Okun, Michael, additional, Castaneda, Juan Ramirez, additional, Metman, Leonard Verhagen, additional, Luca, Corneliu, additional, Ramdhani, Ritesh, additional, Durphy, Jennifer, additional, Bezchlibnyk, Yarema, additional, Carlson, Jonathan, additional, Foote, Kelly, additional, Sani, Sepehr, additional, Papanastassiou, Alexander, additional, Jagid, Jonathan, additional, Weintraub, David, additional, Pilitsis, Julie, additional, Reese, Ben, additional, Chen, Lilly, additional, Shivacharan, Rajat, additional, and Goldberg, Edward, additional

Published
2024
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4. Real-world Outcomes Using DBS Systems with Directionality and Multiple Independent Current Control: USA Experience (P1-3.007)

Author

Okun, Michael, primary, Foote, Kelly, additional, Zesiewicz, Theresa, additional, Bezchlibnyk, Yarema, additional, Papanastassiou, Alexander, additional, Castaneda, Juan Ramirez, additional, Carlson, Jonathan, additional, Aldred, Jason, additional, Krishna, Vibhor, additional, Luca, Corneliu, additional, Jagid, Jonathan, additional, Durphy, Jennifer, additional, Metman, Leonard Verhagen, additional, Sani, Sepehr, additional, Ojemann, Steven, additional, Kern, Drew, additional, Ramdhani, Ritesh, additional, Weintraub, David, additional, Siadati, Abdolreza, additional, Sundaram, Bharathy, additional, Zhao, Cong Zhi, additional, Martinez, Derek, additional, Siddiqui, Mustafa, additional, Tatter, Stephen, additional, Chen, Lilly, additional, and Goldberg, Edward, additional

Published
2024
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5. EP013 / #143 IMPACT OF IMAGE-GUIDED PROGRAMMING (IGP) ON INITIAL DBS CLINIC VISIT TIMES AND OUTCOMES

Author

Aldred, Jason, primary, Zesiewicz, Theresa, additional, Okun, Michael S., additional, Ramirez-Castaneda, Juan, additional, Verhagen-Metman, Leo, additional, Luca, Corneliu, additional, Ramdhani, Ritesh, additional, Durphy, Jennifer, additional, Bezchlibnyk, Yarema, additional, Carlson, Jonathan, additional, Foote, Kelly, additional, Sani, Sepehr, additional, Papanastassiou, Alexander, additional, Jagid, Jonathan, additional, Weintraub, David, additional, Pilitsis, Julie, additional, Reese, Benjamin, additional, Chen, Lilly, additional, and Goldberg, Edward, additional

Published
2023
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9. ID: 197707 Quality-of-Life Improvement and Patient's Impression of Change With Use of Directional DBS Therapy for PD

Author

Zesiewicz, Theresa, primary, Volkmann, Jens, additional, Barbe, Michael, additional, Paschen, Steffen, additional, Luca, Corneliu, additional, Zhao, Cong Zhi, additional, Ponce, Francisco, additional, Clement, Frederik, additional, Durphy, Jennifer, additional, Loret, Griet, additional, Prell, Tino, additional, Ostrem, Jill, additional, Siddiqui, Mustafa, additional, Tomycz, Nestor, additional, Pei, Yu, additional, and Jain, Roshini, additional

Published
2023
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11. Real-World Outcomes in USA using DBS Systems with Directionality and Multiple Independent Current Control (P5-11.017)

Author

Okun, Michael, primary, Foote, Kelly, additional, Zesiewicz, Theresa, additional, Bezchlibnyk, Yarema, additional, Papanastassiou, Alexander, additional, Carlson, Jonathan, additional, Aldred, Jason, additional, Krishna, Vibhor, additional, Merola, Aristide, additional, Luca, Corneliu, additional, Jagid, Jonathan, additional, Durphy, Jennifer, additional, Metman, Leonard Verhagen, additional, Sani, Sepehr, additional, Ojemann, Steven, additional, Kern, Drew, additional, Weintraub, David, additional, Ramdhani, Ritesh, additional, Siadati, Abdolreza, additional, Sundaram, Bharathy, additional, Zhao, Cong Zhi, additional, Martinez, Derek, additional, Siddiqui, Mustafa, additional, Tatter, Stephen, additional, Chen, Lilly, additional, and Jain, Roshini, additional

Published
2023
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12. Image-Guided Programming Tool for DBS Programming Used with a Multiple-Source, Constant-Current System Reduces Initial Programming Time (P4-11.012)

Author

Aldred, Jason, primary, Zesiewicz, Theresa, additional, Okun, Michael, additional, Castaneda, Juan Ramirez, additional, Metman, Leonard Verhagen, additional, Luca, Corneliu, additional, Ramdhani, Ritesh, additional, Durphy, Jennifer, additional, Bezchlibnyk, Yarema, additional, Carlson, Jonathan, additional, Foote, Kelly, additional, Sani, Sepehr, additional, Papanastassiou, Alexander, additional, Jagid, Jonathan, additional, Weintraub, David, additional, Pilitsis, Julie, additional, Chen, Lilly, additional, and Jain, Roshini, additional

Published
2023
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13. O132 / #543 REAL-WORLD DEEP BRAIN STIMULATION OUTCOMES USING SYSTEMS WITH DIRECTIONALITY AND MULTIPLE INDEPENDENT CURRENT CONTROL

Author

Zesiewicz, Theresa, primary, Barbe, Michael, additional, Paschen, Steffen, additional, Luca, Corneliu, additional, Zhao, Cong Zhi, additional, Ponce, Francisco, additional, Durphy, Jennifer, additional, Ostrem, Jill, additional, Tomycz, Nestor, additional, Prell, Tino, additional, Pei, Yu, additional, and Jain, Roshini, additional

Published
2022
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14. PO269 / #622 PROGRAMMING TIME AND THE USE OF A VISUALIZATION TOOL FOR DBS PROGRAMMING OF A MULTIPLE-SOURCE, CONSTANT-CURRENT SYSTEM

Author

Aldred, Jason, primary, Zesiewicz, Theresa, additional, Okun, Michael, additional, Ramirez-Castaneda, Juan, additional, Verhagen-Metman, Leo, additional, Luca, Corneliu, additional, Ramdhani, Ritesh, additional, Durphy, Jennifer, additional, Bezchlibnyk, Yarema, additional, Foote, Kelly, additional, Sani, Sepehr, additional, Papanastassiou, Alexander, additional, Carlson, Jonathan, additional, Jagid, Jonathan, additional, Weintraub, David, additional, Pilitsis, Julie, additional, Pei, Yu, additional, and Jain, Roshini, additional

Published
2022
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15. ID: 318062 Assessment of lmage-Guided Programming (IGP) on Bilateral STN and GPi Deep Brain Stimulation Programming Time

Author

Aldred, Jason, Zesiewicz, Theresa, Okun, Michael, Ramirez-Castaneda, Juan, Verhagen-Metman, Leo, Luca, Corneliu, Ramdhani, Ritesh, Durphy, Jennifer, Bezchlibnyk, Yarema, Carlson, Jonathan, Foote, Kelly, Sani, Sepehr, Papanastassiou, Alexander, Jagid, Jonathan, Weintraub, David, Pilitsis, Julie, Reese, Benjamin, and Chen, Lilly

Published
2024
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16. ID: 309438 Real-World Outcomes Using DBS Systems With Directionality and Multiple Independent Current Control: USA Experience

Author

Okun, Michael, Foote, Kelly, Zesiewicz, Theresa, Bezchlibnyk, Yarema, Papanastassiou, Alexander, Ramirez-Castaneda, Juan, Carlson, Jonathan, Aldred, Jason, Krishna, Vibhor, Luca, Corneliu, Jagid, Jonathan, Durphy, Jennifer, Verhagen-Metman, Leo, Sani, Sepehr, Ojemann, Steven, Kern, Drew, Weintraub, David, Ramdhani, Ritesh, Siadati, Abdolreza, Sundaram, Bharathy, Zhao, Cong Zhi, Martinez, Derek, Siddiqui, Mustafa, Tatter, Stephen, and Chen, Lilly

Published
2024
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17. P070 REAL-WORLD OUTCOMES USING DBS SYSTEMS WITH DIRECTIONALITY AND MULTIPLE INDEPENDENT CURRENT CONTROL: USA EXPERIENCE

Author

Okun, Michael, Foote, Kelly, Zesiewicz, Theresa, Bezchlibnyk, Yarema, Papanastassiou, Alexander, Ramirez-Castaneda, Juan, Carlson, Jonathan, Aldred, Jason, Krishna, Vibhor, Luca, Corneliu, Jagid, Jonathan, Durphy, Jennifer, Metman, Leo Verhagen, Sani, Sepehr, Ojemann, Steven, Kern, Drew, Weintraub, David, Ramdhani, Ritesh, Siadati, Abdolreza, Sundaram, Bharathy, Zhao, Cong, Martinez, Derek, Siddiqui, Mustafa, Tatter, Stephen, Chen, Lilly, Shivacharan, Rajat, and Goldberg, Edward

Published
2025
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18. ID:16220 Visualization Tool for DBS Programming Used With a Multiple-Source, Constant-Current System Reduces Initial Programming Time

Author

Aldred, Jason, primary, Zesiewicz, Theresa, additional, Okun, Michael, additional, Ramirez-Castaneda, Juan, additional, Verhagen-Metman, Leo, additional, Luca, Corneliu, additional, Ramdhani, Ritesh, additional, Durphy, Jennifer, additional, Bezchlibnyk, Yarema, additional, Carlson, Jonathan, additional, Foote, Kelly, additional, Sani, Sepehr, additional, Papanastassiou, Alexander, additional, Jagid, Jonathan, additional, Weintraub, David, additional, Pilitsis, Julie, additional, Chen, Lilly, additional, and Jain, Roshini, additional

Published
2022
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20. Programming Time and the Use of a Visualization Tool for DBS Programming of a Multiple-Source, Constant-Current System (P5-11.006)

Author

Aldred, Jason, primary, Zesiewicz, Theresa, additional, Ramirez-Castaneda, Juan, additional, Okun, Michael, additional, Luca, Corneliu, additional, Ramdhani, Ritesh, additional, Verhagen-Metman, Leo, additional, Durphy, Jennifer, additional, Siddiqui, Mustafa, additional, Bezchlibnyk, Yarema, additional, Carlson, Jonathan, additional, Foote, Kelly, additional, Sani, Sepehr, additional, Papanastassiou, Alexander, additional, Weintraub, David, additional, Jagid, Jonathan, additional, Pilitsis, Julie, additional, Chen, Lilly, additional, and Jain, Roshini, additional

Published
2022
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21. Real-World Deep Brain Stimulation Outcomes Using DBS Systems with Directionality and Multiple Independent Current Control (P2-11.003)

Author

Zesiewicz, Theresa, primary, Barbe, Michael, additional, Paschen, Steffen, additional, Luca, Corneliu, additional, Zhao, Cong Zhi, additional, Ponce, Francisco, additional, Durphy, Jennifer, additional, Ostrem, Jill, additional, Tomycz, Nestor, additional, Prell, Tino, additional, Siddiqui, Mustafa, additional, Chen, Lilly, additional, and Jain, Roshini, additional

Published
2022
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22. Use of Functional MRI to Assess Effects of Deep Brain Stimulation Frequency Changes on Brain Activation in Parkinson Disease

Author

DiMarzio, Marisa, primary, Madhavan, Radhika, additional, Hancu, Ileana, additional, Fiveland, Eric, additional, Prusik, Julia, additional, Joel, Suresh, additional, Gillogly, Michael, additional, Telkes, Ilknur, additional, Staudt, Michael D, additional, Durphy, Jennifer, additional, Shin, Damian, additional, and Pilitsis, Julie G, additional

Published
2021
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23. Sex-specific effects of subthalamic nucleus stimulation on pain in Parkinson’s disease

Author

Khazen, Olga, primary, DiMarzio, Marisa, additional, Platanitis, Kelsey, additional, Grimaudo, Heather C., additional, Hancu, Maria, additional, Shao, Miriam M., additional, Staudt, Michael D., additional, Maguire, Lucy, additional, Sukul, Vishad V., additional, Durphy, Jennifer, additional, Hanspal, Era K., additional, Adam, Octavian, additional, Molho, Eric, additional, and Pilitsis, Julie G., additional

Published
2021
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24. P056 ASSESSMENT OF IMAGE-GUIDED PROGRAMMING (IGP) ON BILATERAL STN AND GPI DEEP BRAIN STIMULATION PROGRAMMING TIME

Author

Aldred, Jason, Zesiewicz, Theresa, Okun, Michael, Ramirez-Castaneda, Juan, Metman, Leo Verhagen, Luca, Corneliu, Ramdhani, Ritesh, Durphy, Jennifer, Bezchlibnyk, Yarema, Carlson, Jonathan, Foote, Kelly, Sani, Sepehr, Papanastassiou, Alexander, Jagid, Jonathan, Weintraub, David, Pilitsis, Julie, Reese, Benjamin, Shivacharan, Rajat, Chen, Lilly, and Goldberg, Edward

Published
2025
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26. ID: 197975 Real-World Outcomes Using DBS Systems With Directionality and Multiple Independent Current Control: USA Experience

Author

Okun, Michael, Foote, Kelly, Zesiewicz, Theresa, Bezchlibnyk, Yarema, Papanastassiou, Alexander, Ramirez-Castaneda, Juan, Carlson, Jonathan, Aldred, Jason, Krishna, Vibhor, Merola, Aristide, Luca, Corneliu, Jagid, Jonathan, Durphy, Jennifer, Verhagen, Leonard, Sani, Sepehr, Ojemann, Steven, Kern, Drew, Weintraub, David, Ramdhani, Ritesh, Siadati, Abdolreza, Sundaram, Bharathy, Zhao, Cong Zhi, Martinez, Derek, Siddiqui, Mustafa, Tatter, Stephen, Chen, Lilly, and Jain, Roshini

Published
2023
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31. Use of Functional Magnetic Resonance Imaging to Assess How Motor Phenotypes of Parkinson's Disease Respond to Deep Brain Stimulation

Author

DiMarzio, Marisa D, primary, Madhavan, Radhika, additional, Joel, Suresh, additional, Hancu, Ileana, additional, Fiveland, Eric, additional, Prusik, Julia, additional, Gillogly, Michael, additional, Rashid, Tanweer, additional, Ashe, Jeffrey, additional, Telkes, Ilknur, additional, Feustel, Paul, additional, Shin, Damian, additional, Durphy, Jennifer, additional, Hwang, Roy S, additional, Hanspal, Era, additional, and Pilitsis, Julie G, additional

Published
2019
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33. Functional MRI Signature of Chronic Pain Relief From Deep Brain Stimulation in Parkinson Disease Patients

Author

DiMarzio, Marisa, primary, Rashid, Tanweer, additional, Hancu, Ileana, additional, Fiveland, Eric, additional, Prusik, Julia, additional, Gillogly, Michael, additional, Madhavan, Radhika, additional, Joel, Suresh, additional, Durphy, Jennifer, additional, Molho, Eric, additional, Hanspal, Era, additional, Shin, Damian, additional, and Pilitsis, Julie G, additional

Published
2019
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35. Use of Functional Magnetic Resonance Imagingto Assess How Motor Phenotypes of Parkinson's Disease Respond to Deep Brain Stimulation

Author

DiMarzio, Marisa, Madhavan, Radhika, Joel, Suresh, Hancu, Ileana, Fiveland, Eric, Prusik, Julia, Gillogly, Michael, Rashid, Tanweer, MacDonell, Jacquelyn, Ashe, Jeffrey, Telkes, Ilknur, Feustel, Paul, Staudt, Michael D, Shin, Damian S., Durphy, Jennifer, Hwang, Roy, Hanspal, Era, and Pilitsis, Julie G.

Abstract

Deep brain stimulation (DBS) is a well‐accepted treatment of Parkinson's disease (PD). Motor phenotypes include tremor‐dominant (TD), akinesia‐rigidity (AR), and postural instability gait disorder (PIGD). The mechanism of action in how DBS modulates motor symptom relief remains unknown. Blood oxygen level‐dependent (BOLD) functional magnetic resonance imaging (fMRI) was used to determine whether the functional activity varies in response to DBS depending on PD phenotypes. Subjects underwent an fMRI scan with DBS cycling ON and OFF. The effects of DBS cycling on BOLD activation in each phenotype were documented through voxel‐wise analysis. For each region of interest, ANOVAs were performed using T‐values and covariate analyses were conducted. Further, a correlation analysis was performed comparing stimulation settings to T‐values. Lastly, T‐values of subjects with motor improvement were compared to those who worsened. As a group, BOLD activation with DBS‐ON resulted in activation in the motor thalamus (p< 0.01) and globus pallidus externa (p< 0.01). AR patients had more activation in the supplementary motor area (SMA) compared to PIGD (p< 0.01) and TD cohorts (p< 0.01). Further, the AR cohort had more activation in primary motor cortex (MI) compared to the TD cohort (p= 0.02). Implanted nuclei (p= 0.01) and phenotype (p= <0.01) affected activity in MI and phenotype alone affected SMA activity (p= <0.01). A positive correlation was seen between thalamic activation and pulse‐width (p= 0.03) and between caudate and total electrical energy delivered (p= 0.04). These data suggest that DBS modulates network activity differently based on patient motor phenotype. Improved understanding of these differences may further our knowledge about the mechanisms of DBS action on PD motor symptoms and to optimize treatment.

Published
2020
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38. The Influence of Bilateral Subthalamic Nucleus Deep Brain Stimulation on Impulsivity and Prepulse Inhibition in Parkinson's Disease Patients

Author

Gee, Lucy, primary, Smith, Heather, additional, De La Cruz, Priscilla, additional, Campbell, Joannalee, additional, Fama, Chris, additional, Haller, Jessica, additional, Ramirez-Zamora, Adolfo, additional, Durphy, Jennifer, additional, Hanspal, Era, additional, Molho, Eric, additional, Barba, Anne, additional, Shin, Damian, additional, and Pilitsis, Julie G., additional

Published
2015
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41. Major Ecological Transitions in Wild Sunflowers Facilitatedby Hybridization.

Author

Rieseberg, Loren H., Raymond, Olivier, Rosenthal, David M., Lai, Zhao, Livingstone, Kevin, Nakazato, Takuya, Durphy, Jennifer L., Schwarzbach, Andrea E., Donovan, Lisa A., and Lexer, Christian

Subjects
*SUNFLOWERS, *WILD flowers, *PLANT hybridization, *HABITATS
Abstract

Hybridization is frequent in many organismal groups, but its role in adaptation is poorly understood. In sunflowers, species found in the most extreme habitats are ancient hybrids, and new gene combinations generated by hybridization are speculated to have contributed to ecological divergence. This possibility was tested through phenotypic and genomic comparisons of ancient and synthetic hybrids. Most trait differences in ancient hybrids could be recreated by complementary gene action in synthetic hybrids and were favored by selection. The same combinations of parental chromosomal segments required to generate extreme phenotypes in synthetic hybrids also occurred in ancient hybrids. Thus, hybridization facilitated ecological divergence in sunflowers. [ABSTRACT FROM AUTHOR]

Published
2003
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42. Effect of Urate-Elevating Inosine on Early Parkinson Disease Progression: The SURE-PD3 Randomized Clinical Trial.

Author

Schwarzschild MA, Ascherio A, Casaceli C, Curhan GC, Fitzgerald R, Kamp C, Lungu C, Macklin EA, Marek K, Mozaffarian D, Oakes D, Rudolph A, Shoulson I, Videnovic A, Scott B, Gauger L, Aldred J, Bixby M, Ciccarello J, Gunzler SA, Henchcliffe C, Brodsky M, Keith K, Hauser RA, Goetz C, LeDoux MS, Hinson V, Kumar R, Espay AJ, Jimenez-Shahed J, Hunter C, Christine C, Daley A, Leehey M, de Marcaida JA, Friedman JH, Hung A, Bwala G, Litvan I, Simon DK, Simuni T, Poon C, Schiess MC, Chou K, Park A, Bhatti D, Peterson C, Criswell SR, Rosenthal L, Durphy J, Shill HA, Mehta SH, Ahmed A, Deik AF, Fang JY, Stover N, Zhang L, Dewey RB Jr, Gerald A, Boyd JT, Houston E, Suski V, Mosovsky S, Cloud L, Shah BB, Saint-Hilaire M, James R, Zauber SE, Reich S, Shprecher D, Pahwa R, Langhammer A, LaFaver K, LeWitt PA, Kaminski P, Goudreau J, Russell D, Houghton DJ, Laroche A, Thomas K, McGraw M, Mari Z, Serrano C, Blindauer K, Rabin M, Kurlan R, Morgan JC, Soileau M, Ainslie M, Bodis-Wollner I, Schneider RB, Waters C, Ratel AS, Beck CA, Bolger P, Callahan KF, Crotty GF, Klements D, Kostrzebski M, McMahon GM, Pothier L, Waikar SS, Lang A, and Mestre T

Subjects
Aged, Biomarkers blood, Dopamine Plasma Membrane Transport Proteins deficiency, Double-Blind Method, Female, Humans, Inosine adverse effects, Kidney Calculi chemically induced, Male, Middle Aged, Parkinson Disease blood, Parkinson Disease physiopathology, Severity of Illness Index, Treatment Failure, Disease Progression, Inosine therapeutic use, Parkinson Disease drug therapy, Uric Acid blood
Abstract

Importance: Urate elevation, despite associations with crystallopathic, cardiovascular, and metabolic disorders, has been pursued as a potential disease-modifying strategy for Parkinson disease (PD) based on convergent biological, epidemiological, and clinical data., Objective: To determine whether sustained urate-elevating treatment with the urate precursor inosine slows early PD progression., Design, Participants, and Setting: Randomized, double-blind, placebo-controlled, phase 3 trial of oral inosine treatment in early PD. A total of 587 individuals consented, and 298 with PD not yet requiring dopaminergic medication, striatal dopamine transporter deficiency, and serum urate below the population median concentration (<5.8 mg/dL) were randomized between August 2016 and December 2017 at 58 US sites, and were followed up through June 2019., Interventions: Inosine, dosed by blinded titration to increase serum urate concentrations to 7.1-8.0 mg/dL (n = 149) or matching placebo (n = 149) for up to 2 years., Main Outcomes and Measures: The primary outcome was rate of change in the Movement Disorder Society Unified Parkinson Disease Rating Scale (MDS-UPDRS; parts I-III) total score (range, 0-236; higher scores indicate greater disability; minimum clinically important difference of 6.3 points) prior to dopaminergic drug therapy initiation. Secondary outcomes included serum urate to measure target engagement, adverse events to measure safety, and 29 efficacy measures of disability, quality of life, cognition, mood, autonomic function, and striatal dopamine transporter binding as a biomarker of neuronal integrity., Results: Based on a prespecified interim futility analysis, the study closed early, with 273 (92%) of the randomized participants (49% women; mean age, 63 years) completing the study. Clinical progression rates were not significantly different between participants randomized to inosine (MDS-UPDRS score, 11.1 [95% CI, 9.7-12.6] points per year) and placebo (MDS-UPDRS score, 9.9 [95% CI, 8.4-11.3] points per year; difference, 1.26 [95% CI, -0.59 to 3.11] points per year; P = .18). Sustained elevation of serum urate by 2.03 mg/dL (from a baseline level of 4.6 mg/dL; 44% increase) occurred in the inosine group vs a 0.01-mg/dL change in serum urate in the placebo group (difference, 2.02 mg/dL [95% CI, 1.85-2.19 mg/dL]; P<.001). There were no significant differences for secondary efficacy outcomes including dopamine transporter binding loss. Participants randomized to inosine, compared with placebo, experienced fewer serious adverse events (7.4 vs 13.1 per 100 patient-years) but more kidney stones (7.0 vs 1.4 stones per 100 patient-years)., Conclusions and Relevance: Among patients recently diagnosed as having PD, treatment with inosine, compared with placebo, did not result in a significant difference in the rate of clinical disease progression. The findings do not support the use of inosine as a treatment for early PD., Trial Registration: ClinicalTrials.gov Identifier: NCT02642393.

Published
2021
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43. Sex-specific effects of subthalamic nucleus stimulation on pain in Parkinson's disease.

Author

Khazen O, DiMarzio M, Platanitis K, Grimaudo HC, Hancu M, Shao MM, Staudt MD, Maguire L, Sukul VV, Durphy J, Hanspal EK, Adam O, Molho E, and Pilitsis JG

Abstract

Objective: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is known to reduce motor symptoms of Parkinson's disease (PD). The effects of DBS on various nonmotor symptoms often differ from patient to patient. The factors that determine whether or not a patient will respond to treatment have not been elucidated. Here, the authors evaluated sex differences in pain relief after DBS for PD., Methods: The authors prospectively evaluated 20 patients preoperatively and postoperatively after bilateral STN DBS with the validated numeric rating scale (NRS), Revised Oswestry Disability Index for low-back pain (RODI), and King's Parkinson's Disease Pain Scale (KPDPS) and assessed the impact of sex as a biological variable., Results: The cohort consisted of 6 female and 14 male patients with a mean duration of 11.8 ± 2.0 months since DBS surgery. Females were significantly older (p = 0.02). Covariate analysis, however, showed no effect of age, stimulation settings, or other confounding variables. KPDPS total scores statistically significantly improved only among males (p < 0.001). Males improved more than females in musculoskeletal and chronic subsets of the KPDPS (p = 0.03 and p = 0.01, respectively). RODI scores significantly improved in males but not in females (p = 0.03 and p = 0.30, respectively). Regarding the NRS score, the improvements seen in both sexes in NRS were not significant., Conclusions: Although it is well recognized that pain complaints in PD are different between men and women, this study is unique in that it examines the sex-specific DBS effects on this symptom. Considering sex as a biological variable may have important implications for DBS pain outcome studies moving forward.

Published
2020
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