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Background: Intravascular large B-cell lymphoma (IVLBCL) is a rare entity among large B-cell non-Hodgkin lymphomas and is often difficult to diagnose. We report the case of a patient with IVLBCL who presented with central nervous system (CNS) symptoms alone, in which positron emission tomography (PET) enabled a rapid and accurate diagnosis. Case Description: An 81-year-old woman was admitted to our hospital with a 3-month history of gradually progressive dementia and declining spontaneity. Magnetic resonance imaging revealed multiple hyperintense lesions bilaterally on diffusion-weighted imaging without enhancement on gadolinium-enhanced T1-weighted imaging. Laboratory findings showed elevated serum lactate dehydrogenase (626 U/L) and soluble interleukin-2 receptor (sIL-2R) (4692 U/mL). Cerebrospinal fluid (CSF) analysis showed slightly elevated levels of protein (166 mg/dL) and lymphocytic cells (29/μL), and β2-microglobulin (β2-MG) (4.6 mg/L) was highly elevated. Whole-body computed tomography revealed faint ground-glass opacities in the upper and middle lung fields and diffuse enlargement of both kidneys without lymph node swelling. 18F-fluorodeoxyglucose (FDG)-PET showed diffuse and remarkably high FDG uptake in both upper lungs and kidneys without uptake by lymph nodes, suggesting a malignant hematological disease. IVLBCL was confirmed histologically by incisional random skin biopsy from the abdomen. Chemotherapy using R-CHOP regimen in combination with intrathecal methotrexate injection was started on day 5 after admission and follow-up neuroimaging showed no signs of recurrence. Conclusion: IVLBCL presenting with CNS symptoms alone is rare and often has a poor prognosis associated with delayed diagnosis, and various evaluations (including systemic analysis) are therefore necessary for early diagnosis. FDG-PET, in addition to identification of clinical symptoms and evaluation of serum sIL-2R and CSF β2-MG, enables rapid therapeutic intervention in IVLBCL presenting with CNS symptoms.

Eine Umsatzzahl (TON) von 2 400 000 und einen Umsatz pro Zeit (TOF) von 63 s−1 ermoglicht der chirale RuII-Komplex 1 (R=p-H3CC6H4) als Katalysator bei der asymmetrischen Hydrierung von Acetophenon. Mit verwandten RuII-Katalysatoren werden α,β-ungesattigte Ketone selektiv an der Carbonylgruppe asymmetrisch hydriert und aus 4-substituierten Cyclohexanonen die entsprechenden cis-Alkohole erhalten.

A turnover number (TON) of 2 400 000 and a turnover frequency (TOF) of 63 s-1 are achieved with the chiral RuII complex 1 (R=p-CH3 C6 H4 ) in the asymmetric hydrogenation of acetophenone. Carbonyl-selective asymmetric hydrogenation of α,β-unsaturated ketones proceeds in the presence of these RuII catalysts, and 4-substituted cyclohexanones are selectively converted into cis alcohols.

A turnover number (TON) of 2 400 000 and a turnover frequency (TOF) of 63 s

Reductive pinacol-type rearrangement of chiral α-mesyloxy ketones was effected by organoaluminums (DIBAL in combination with Et 3 Al or Et 2 AlCl) leading to enantiomerically pure 2-aryl- or 2-alkenyl-1-propanols.

All four diastereomere of chiral alcohol 2 with three contiguous chiral centers were stereoselectively prepared via diastereoselective addition of nucleophiles (crotyl metal or H-) to α-methyl-β,γ-unsaturated carbonyl compounds 1 .

Asymmetric (stereospecific) pinacol-type rearrangement of aryl or vinyl group in α-hydroxy methanesulfonates is promoted by Et3Al in CH2Cl2 at −78°C to afford optically pure α-aryl or α-vinyl ketones.

Reduction of α-methyl-β,γ-unsaturated ketones with L-Selectride proceeded with high threo -selectivity to afford threo -β-methyl homoallylic alcohols of high enantio- and diastereomerical purities.

Optically pure α-methyl-β,γ-unsaturated ketones are synthesized by the Et3Al-mediated pinacol-type rearrangement where alkenyl groups migrate stereospecifically with complete retention of the olefin-geometry.

Two chiral intermediates, C(1)–C(9) and C(11)–C(17) portionsof protomycinolide IV, were synthesized both from (S)-ethyl lactatevia asymmetric pinacol-type rearrangement followed bydiastereoselective reactions on α-methyl-β,γ-unsaturatedcarbonyl compounds.