1. The study of the possibility of drug dissolution of gallbladder calculi
- Author
-
Ekaterina Dikman, Anatoly Chirev, and Alexey Soldatov
- Subjects
medicine.medical_specialty ,Cholesterol calculus ,business.industry ,Gallbladder ,0206 medical engineering ,Ultrasound ,Urology ,Ultrasound exposure ,02 engineering and technology ,Conventional ultrasound ,020601 biomedical engineering ,Industrial and Manufacturing Engineering ,Ursodeoxycholic acid ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,medicine ,030211 gastroenterology & hepatology ,Dissolution testing ,Electrical and Electronic Engineering ,business ,Pig liver ,medicine.drug - Abstract
Purpose The purpose of this paper is to verify the possibility of ultrasonic intensification of drug dissolution of cholesterol calculi of the gallbladder using conventional ultrasound frequency and intensity from 0.1 to 0.5 W/cm2. Design/methodology/approach For research purposes, the physical model was developed containing pig bile, pig liver, pigskin, fat and muscles, as well as human cholesterol calculus removed by surgery and a drug with ursodeoxycholic acid. Findings The studies have shown the possibility of accelerating the drug dissolution of calculi of the gallbladder with ultrasound exposure. The ultrasound intensity of 0.4 W/cm2 is the most preferable to intensify the dissolution of calculus. Originality/value The results will be used to advance with development of the device and methodology for ultrasonic intensification of drug dissolution of gallbladder calculi.
- Published
- 2020