15 results on '"Elena Carboni"'
Search Results
2. Repurposing Ketamine in Depression and Related Disorders: Can This Enigmatic Drug Achieve Success?
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Ezio Carboni, Anna R. Carta, Elena Carboni, and Antonello Novelli
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depression ,anxiety ,suicide ,glutamate ,esketamine ,drug repositioning ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Repurposing ketamine in the therapy of depression could well represent a breakthrough in understanding the etiology of depression. Ketamine was originally used as an anesthetic drug and later its use was extended to other therapeutic applications such as analgesia and the treatment of addiction. At the same time, the abuse of ketamine as a recreational drug has generated a concern for its psychotropic and potential long-term effects; nevertheless, its use as a fast acting antidepressant in treatment-resistant patients has boosted the interest in the mechanism of action both in psychiatry and in the wider area of neuroscience. This article provides a comprehensive overview of the actions of ketamine and intends to cover: (i) the evaluation of its clinical use in the treatment of depression and suicidal behavior; (ii) the potential use of ketamine in pediatrics; (iii) a description of its mechanism of action; (iv) the involvement of specific brain areas in producing antidepressant effects; (v) the potential interaction of ketamine with the hypothalamic-pituitary-adrenal axis; (vi) the effect of ketamine on neuronal transmission in the bed nucleus of stria terminalis and on its output; (vii) the evaluation of any gender-dependent effects of ketamine; (viii) the interaction of ketamine with the inflammatory processes involved in depression; (ix) the evaluation of the effects observed with single or repeated administration; (x) a description of any adverse or cognitive effects and its abuse potential. Finally, this review attempts to assess whether ketamine’s use in depression can improve our knowledge of the etiopathology of depression and whether its therapeutic effect can be considered an actual cure for depression rather than a therapy merely aimed to control the symptoms of depression.
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- 2021
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- View/download PDF
3. Changing Admission Patterns in Pediatric Emergency Departments during the COVID-19 Pandemic in Italy Were Due to Reductions in Inappropriate Accesses
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Ivana Rabbone, Francesco Tagliaferri, Elena Carboni, Beatrice Crotti, Jessica Ruggiero, Alice Monzani, Lorenza Bonetti, Martina Soliani, Simonetta Bellone, Claudio Cavalli, and Andrea E. Scaramuzza
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COVID-19 ,pediatrics ,emergency department ,inappropriate accesses ,Pediatrics ,RJ1-570 - Abstract
During the initial phase of the national lockdown, we found that there were sharp decreases in admissions to two pediatric emergency departments (EDs) in northern Italy (Cremona and Novara). Here we present a detailed analysis of these admission patterns and types of admissions over a longer timeframe. ED admissions data were anonymously extracted from the departmental management software. Admissions data from 2019 and 2020 were analyzed and compared separately for each ED and combined. There was a 73.2% decrease in total admissions compared with the same period in 2019. With respect to admission diagnoses, there was a significant (p < 0.001) drop in infectious (−51%), respiratory (−25.5%), and nervous systems diseases (−50%) and injuries and poisoning (−17%) but not endocrine, metabolic, neoplastic, circulatory, or musculoskeletal diseases. White codes (patients with minor injuries for whom ED medical care is not required) significantly decreased by 56.3% (p < 0.001). Even if the COVID-19 pandemic represented an enormous healthcare burden in Italy, especially during the first months of the pandemic (late February to May), the workload of pediatric EDs was significantly reduced, especially for unnecessary accesses (white codes).
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- 2021
- Full Text
- View/download PDF
4. Case Report: Acute hemorrhagic edema of infancy (Seidlmayer purpura) – a dramatic presentation for a benign disease [version 1; peer review: 2 approved]
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Elena Carboni, Maria Scavone, Ettore Stefanelli, Valentina Talarico, Stefania Zampogna, Maria Concetta Galati, and Giuseppe Raiola
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Medicine ,Science - Abstract
We present a case of an 11-month-old girl who was referred to our unit for an erythematous rash that appeared on the face and extremities. Personal and family history was not relevant. Laboratory tests were normal. During recovery, diameter and colour intensity of the cutaneous lesions increased, but after some weeks, lesions had a self-limited resolution without any treatment. Based on clinical and laboratory findings, a diagnosis of acute hemorrhagic edema of infancy (AHEI) was made. AHEI is a rare cutaneous leukocytoclastic vasculitis that usually affects children aged between 4 and 24 months. Etiology is unknown but almost of 75% of cases are preceded by infectious episodes, vaccinations or use of medications. In contrast to the dramatic cutaneous eruption, clinical conditions are usually optimal. Classically, AHEI is characterized by a triad of symptoms: fever, edema and purpura. Skin lesions are erythematous, annular, medallion-like, purpuric plaques that have a rapid onset and appear on the face and extremities, sparing trunk and mucosal membranes. Initially interpreted as a variant of Henoch-Schönlein purpura, now it is considered a distinct disease. In the majority of cases the disease is benign and self-limited without a visceral involvement, so a conservative approach is most often chosen.
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- 2019
- Full Text
- View/download PDF
5. How molecular allergology can shape the management of allergic airways diseases
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Davide Caimmi, Pascal Demoly, Enrica Manca, Elena Carboni, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Università degli Studi di Foggia - University of Foggia, and Università degli Studi 'Magna Graecia' di Catanzaro [Catanzaro, Italie] (UMG)
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Allergen immunotherapy ,Allergy ,MESH: Allergens ,MESH: Asthma ,Immunology ,MESH: Molecular Diagnostic Techniques ,Disease ,Cross Reactions ,Immunologic Tests ,Immunoglobulin E ,medicine.disease_cause ,[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,MESH: Cross Reactions ,03 medical and health sciences ,0302 clinical medicine ,Allergen ,medicine ,Humans ,Immunology and Allergy ,030212 general & internal medicine ,MESH: Desensitization, Immunologic ,[SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology ,Sensitization ,MESH: Treatment Outcome ,Asthma ,[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics ,MESH: Humans ,biology ,business.industry ,MESH: Immunoglobulin E ,Allergens ,medicine.disease ,Rhinitis, Allergic ,3. Good health ,Treatment Outcome ,medicine.anatomical_structure ,Molecular Diagnostic Techniques ,030228 respiratory system ,Desensitization, Immunologic ,MESH: Immunologic Tests ,MESH: Rhinitis, Allergic ,biology.protein ,Personalized medicine ,business - Abstract
International audience; In allergy, personalized medicine passes through the assessment of molecular allergens sensitization profiles. Such technique may help to better diagnose and treat patients suffering from allergic respiratory diseases.Recent findings: Different laboratory tests are available today to assess sensitization to molecular allergens, from singleplex assays, to unspecific, screening multiplex assays, mainly performed through microarrays or macroarrays. It is important to collect both results from specific IgE toward allergen extracts and toward molecular allergens, to collect the most complete information on the patient's profile, and therefore to highlight genuine sensitization, and exclude cross-reaction and sensitization because of pan-allergens. Being able to know the exact molecular sensitization profile of the patient, also helps predicting the possible evolution of the disease, and targeting the most appropriate allergen immunotherapy treatment to prescribe.Summary: Even though a cost-effective analysis of running multiple assays in allergic patients has not been performed yet, such technique proved to be more efficient in detecting the appropriate treatment in each patient and in analyzing the true sensitization profile in patients suffering from allergic rhinitis, conjunctivitis, and asthma.
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- 2020
6. Changing Admission Patterns in Pediatric Emergency Departments during the COVID-19 Pandemic in Italy Were Due to Reductions in Inappropriate Accesses
- Author
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Andrea Scaramuzza, Alice Monzani, Jessica Ruggiero, C Cavalli, Elena Carboni, Francesco Tagliaferri, Martina Soliani, Lorenza Bonetti, Ivana Rabbone, Beatrice Crotti, and S. Bellone
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Pediatric emergency ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,pediatrics ,emergency department ,business.industry ,COVID-19 ,Workload ,Emergency department ,Medical care ,humanities ,Article ,RJ1-570 ,Departmental management ,inappropriate accesses ,Pediatrics, Perinatology and Child Health ,Emergency medicine ,Pandemic ,Health care ,medicine ,business - Abstract
During the initial phase of the national lockdown, we found that there were sharp decreases in admissions to two pediatric emergency departments (EDs) in northern Italy (Cremona and Novara). Here we present a detailed analysis of these admission patterns and types of admissions over a longer timeframe. ED admissions data were anonymously extracted from the departmental management software. Admissions data from 2019 and 2020 were analyzed and compared separately for each ED and combined. There was a 73.2% decrease in total admissions compared with the same period in 2019. With respect to admission diagnoses, there was a significant (p <, 0.001) drop in infectious (−51%), respiratory (−25.5%), and nervous systems diseases (−50%) and injuries and poisoning (−17%) but not endocrine, metabolic, neoplastic, circulatory, or musculoskeletal diseases. White codes (patients with minor injuries for whom ED medical care is not required) significantly decreased by 56.3% (p <, 0.001). Even if the COVID-19 pandemic represented an enormous healthcare burden in Italy, especially during the first months of the pandemic (late February to May), the workload of pediatric EDs was significantly reduced, especially for unnecessary accesses (white codes).
- Published
- 2021
7. Consensus statement of the Italian society of pediatric allergy and immunology for the pragmatic management of children and adolescents with allergic or immunological diseases during the COVID-19 pandemic
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Fabio Cardinale, Giorgio Ciprandi, Salvatore Barberi, Roberto Bernardini, Carlo Caffarelli, Mauro Calvani, Giovanni Cavagni, Elena Galli, Domenico Minasi, Michele Miraglia Del Giudice, Viviana Moschese, Elio Novembre, Francesco Paravati, Diego G Peroni, Maria Angela Tosca, Giovanni Traina, Salvatore Tripodi, Gian Luigi Marseglia, Doriana Amato, Caterina Anania, Elisa Anastasio, Rachele Antignani, Stefania Arasi, Martire Baldassarre, Ermanno Baldo, Andrea Barbalace, Simona Barni, Federica Betti, Annamaria Bianchi, Ezio Bolzacchini, Maira Bonini, Paolo Bottau, Sara Bozzetto, Maria Antonia Brighetti, Davide Caimmi, Silvia Caimmi, Luigi Calzone, Caterina Cancrini, Lucia Caminiti, Giulia Capata, Lucetta Capra, Carlo Capristo, Elena Carboni, Francesco Carella, Riccardo Castagnoli, Elena Chiappini, Fernanda Chiera, Iolanda Chinellato, Loredana Chini, Francesca Cipriani, Flavio Civitelli, Pasquale Comberiati, Daniele Contini, Stefania Corrente, Claudio Cravidi, Giuseppe Crisafulli, Barbara Cuomo, Enza D'Auria, Sofia D'Elios, Fabio Decimo, Auro Della Giustina, Rosa Maria Delle Piane, Maria De Filippo, Valentina De Vittori, Lucia Diaferio, Maria Elisa Di Cicco, Dora Di Mauro, Marzia Duse, Silvia Federici, Giuseppe Felice, Maria Grazia Fenu, Giuliana Ferrante, Tiziana Foti, Fabrizio Franceschini, Daniele Ghiglioni, Giuliana Giardino, Mattia Giovannini, Giovanni Cosimo Indirli, Cristiana Indolfi, Massimo Landi, Francesco La Torre, Lucia Maddalena Leone, Amelia Licari, Lucia Liotti, Vassilios Lougaris, Nunzia Maiello, Paride Mantecca, Sara Manti, Marco Maria Mariani, Alberto Martelli, Carla Mastrorilli, Violetta Mastrorilli, Davide Montin, Francesca Mori, Roberta Olcese, Giorgio Ottaviano, Claudia Paglialunga, Giovanni Pajno, Giuseppe Parisi, Stefano Pattini, Luca Pecoraro, Umberto Pelosi, Claudio Pignata, Giampaolo Ricci, Silvia Ricci, Stefano Rizzi, Caterina Rizzo, Sara Rosati, Paolo Rosso, Maria Sangerardi, Angelica Santoro, Francesca Saretta, Lucrezia Sarti, Marco Sartorio, Majla Sgruletti, Annarosa Soresina, Ifigenia Sfika, Mayla Sgrulletti, Nuccia Tesse, Valentina Tranchino, Alessandro Travaglini, Malizia Velia, Elvira Verduci, Mario Vernich, Elisabetta Veronelli, Stefano Volpi, Martina Votto, Anna Maria Zicari, Cardinale, F., Ciprandi, G., Barberi, S., Bernardini, R., Caffarelli, C., Calvani, M., Cavagni, G., Galli, E., Minasi, D., Del Giudice, M. M., Moschese, V., Novembre, E., Paravati, F., Peroni, D. G., Tosca, M. A., Traina, G., Tripodi, S., Marseglia, G. L., Amato, D., Anania, C., Anastasio, E., Antignani, R., Arasi, S., Baldassarre, M., Baldo, E., Barbalace, A., Barni, S., Betti, F., Bianchi, A., Bolzacchini, E., Bonini, M., Bottau, P., Bozzetto, S., Brighetti, M. A., Caimmi, D., Caimmi, S., Calzone, L., Cancrini, C., Caminiti, L., Capata, G., Capra, L., Capristo, C., Carboni, E., Carella, F., Castagnoli, R., Chiappini, E., Chiera, F., Chinellato, I., Chini, L., Cipriani, F., Civitelli, F., Comberiati, P., Contini, D., Corrente, S., Cravidi, C., Crisafulli, G., Cuomo, B., D'Auria, E., D'Elios, S., Decimo, F., Giustina, A. D., Piane, R. M. D., De Filippo, M., De Vittori, V., Diaferio, L., Di Mauro, M. E., Duse, M., Federici, S., Felice, G., Fenu, G., Ferrante, G., Foti, T., Franceschini, F., Ghiglioni, D., Giardino, G., Giovannini, M., Indirli, G. C., Indolfi, C., Landi, M., La Torre, F., Leone, L. M., Licari, A., Liotti, L., Lougaris, V., Maiello, N., Mantecca, P., Manti, S., Mariani, M. M., Martelli, A., Mastrorilli, C., Mastrorilli, V., Montin, D., Mori, F., Olcese, R., Ottaviano, G., Paglialunga, C., Pajno, G., Parisi, G., Pattini, S., Pecoraro, L., Pelosi, U., Pignata, C., Ricci, G., Ricci, S., Rizzi, S., Rizzo, C., Rosati, S., Rosso, P., Sangerardi, M., Santoro, A., Saretta, F., Sarti, L., Sartorio, M., Sgruletti, M., Soresina, A., Sfika, I., Sgrulletti, M., Tesse, N., Tranchino, V., Travaglini, A., Velia, M., Verduci, E., Vernich, M., Veronelli, E., Volpi, S., Votto, M., Zicari, A. M., Cardinale, Fabio, Ciprandi, Giorgio, Barberi, Salvatore, Bernardini, Roberto, Caffarelli, Carlo, Calvani, Mauro, Cavagni, Giovanni, Galli, Elena, Minasi, Domenico, Del Giudice, Michele Miraglia, Moschese, Viviana, Novembre, Elio, Paravati, Francesco, Peroni, Diego G, Tosca, Maria Angela, Traina, Giovanni, Tripodi, Salvatore, Marseglia, Gian Luigi, SIAIP task force Pignata, Claudio, Cardinale, F, Ciprandi, G, Barberi, S, Bernardini, R, Caffarelli, C, Calvani, M, Cavagni, G, Galli, E, Minasi, D, Del Giudice, M, Moschese, V, Novembre, E, Paravati, F, Peroni, D, Tosca, M, Traina, G, Tripodi, S, Marseglia, G, Amato, D, Anania, C, Anastasio, E, Antignani, R, Arasi, S, Baldassarre, M, Baldo, E, Barbalace, A, Barni, S, Betti, F, Bianchi, A, Bolzacchini, E, Bonini, M, Bottau, P, Bozzetto, S, Brighetti, M, Caimmi, D, Caimmi, S, Calzone, L, Cancrini, C, Caminiti, L, Capata, G, Capra, L, Capristo, C, Carboni, E, Carella, F, Castagnoli, R, Chiappini, E, Chiera, F, Chinellato, I, Chini, L, Cipriani, F, Civitelli, F, Comberiati, P, Contini, D, Corrente, S, Cravidi, C, Crisafulli, G, Cuomo, B, D'Auria, E, D'Elios, S, Decimo, F, Giustina, A, Piane, R, De Filippo, M, De Vittori, V, Diaferio, L, Di Mauro, M, Duse, M, Federici, S, Felice, G, Fenu, G, Ferrante, G, Foti, T, Franceschini, F, Ghiglioni, D, Giardino, G, Giovannini, M, Indirli, G, Indolfi, C, Landi, M, La Torre, F, Leone, L, Licari, A, Liotti, L, Lougaris, V, Maiello, N, Mantecca, P, Manti, S, Mariani, M, Martelli, A, Mastrorilli, C, Mastrorilli, V, Montin, D, Mori, F, Olcese, R, Ottaviano, G, Paglialunga, C, Pajno, G, Parisi, G, Pattini, S, Pecoraro, L, Pelosi, U, Pignata, C, Ricci, G, Ricci, S, Rizzi, S, Rizzo, C, Rosati, S, Rosso, P, Sangerardi, M, Santoro, A, Saretta, F, Sarti, L, Sartorio, M, Sgruletti, M, Soresina, A, Sfika, I, Sgrulletti, M, Tesse, N, Tranchino, V, Travaglini, A, Velia, M, Verduci, E, Vernich, M, Veronelli, E, Volpi, S, Votto, M, Zicari, A, and Fabio Cardinale, Giorgio Ciprandi, Salvatore Barberi, Roberto Bernardini, Carlo Caffarelli, Mauro Calvani, Giovanni Cavagni, Elena Galli, Domenico Minasi, Michele Miraglia Del Giudice, Viviana Moschese, Elio Novembre, Francesco Paravati, Diego G Peroni, Maria Angela Tosca, Giovanni Traina, Salvatore Tripodi, Gian Luigi Marseglia, Doriana Amato, Caterina Anania, Elisa Anastasio, Rachele Antignani, Stefania Arasi, Martire Baldassarre, Ermanno Baldo, Andrea Barbalace, Simona Barni, Federica Betti, Annamaria Bianchi, Ezio Bolzacchini, Maira Bonini, Paolo Bottau, Sara Bozzetto, Maria Antonia Brighetti, Davide Caimmi, Silvia Caimmi, Luigi Calzone, Caterina Cancrini, Lucia Caminiti, Giulia Capata, Lucetta Capra, Carlo Capristo, Elena Carboni, Francesco Carella, Riccardo Castagnoli, Elena Chiappini, Fernanda Chiera, Iolanda Chinellato, Loredana Chini, Francesca Cipriani, Flavio Civitelli, Pasquale Comberiati, Daniele Contini, Stefania Corrente, Claudio Cravidi, Giuseppe Crisafulli, Barbara Cuomo, Enza D'Auria, Sofia D'Elios, Fabio Decimo, Auro Della Giustina, Rosa Maria Delle Piane, Maria De Filippo, Valentina De Vittori, Lucia Diaferio, Maria Elisa Di Cicco, Dora Di Mauro, Marzia Duse, Silvia Federici, Giuseppe Felice, Maria Grazia Fenu, Giuliana Ferrante, Tiziana Foti, Fabrizio Franceschini, Daniele Ghiglioni, Giuliana Giardino, Mattia Giovannini, Giovanni Cosimo Indirli, Cristiana Indolfi, Massimo Landi, Francesco La Torre, Lucia Maddalena Leone, Amelia Licari, Lucia Liotti, Vassilios Lougaris, Nunzia Maiello, Paride Mantecca, Sara Manti, Marco Maria Mariani, Alberto Martelli, Carla Mastrorilli, Violetta Mastrorilli, Davide Montin, Francesca Mori, Roberta Olcese, Giorgio Ottaviano, Claudia Paglialunga, Giovanni Pajno, Giuseppe Parisi, Stefano Pattini, Luca Pecoraro, Umberto Pelosi, Claudio Pignata, Giampaolo Ricci, Silvia Ricci, Stefano Rizzi, Caterina Rizzo, Sara Rosati, Paolo Rosso, Maria Sangerardi, Angelica Santoro, Francesca Saretta, Lucrezia Sarti, Marco Sartorio, Majla Sgruletti, Annarosa Soresina, Ifigenia Sfika, Mayla Sgrulletti, Nuccia Tesse, Valentina Tranchino, Alessandro Travaglini, Malizia Velia, Elvira Verduci, Mario Vernich, Elisabetta Veronelli, Stefano Volpi, Martina Votto, Anna Maria Zicari
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Allergy ,Review ,030207 dermatology & venereal diseases ,Settore MED/38 - Pediatria Generale E Specialistica ,0302 clinical medicine ,COVID-19 ,Child ,Pandemic ,Immunologic disease ,Asthma ,Adolescent ,Viral ,030212 general & internal medicine ,Disease management (health) ,Societies, Medical ,pandemic ,child ,adolescent ,allergy ,asthma ,immunologic disease ,Incidence (epidemiology) ,lcsh:RJ1-570 ,Disease Management ,General Medicine ,Atopic dermatitis ,Settore MED/38 ,Coronavirus Infections ,Decision Making ,Humans ,Italy ,Pneumonia, Viral ,Pragmatic Clinical Trials as Topic ,SARS-CoV-2 ,Allergy and Immunology ,Betacoronavirus ,Consensus ,Pandemics ,Latex allergy ,Human ,Telemedicine ,Consensu ,03 medical and health sciences ,Medical ,medicine ,Risk factor ,Betacoronaviru ,business.industry ,Coronavirus Infection ,lcsh:Pediatrics ,Pneumonia ,medicine.disease ,Immunology ,Societies ,business ,Rare disease - Abstract
The COVID-19 pandemic has surprised the entire population. The world has had to face an unprecedented pandemic. Only, Spanish flu had similar disastrous consequences. As a result, drastic measures (lockdown) have been adopted worldwide. Healthcare service has been overwhelmed by the extraordinary influx of patients, often requiring high intensity of care. Mortality has been associated with severe comorbidities, including chronic diseases. Patients with frailty were, therefore, the victim of the SARS-COV-2 infection. Allergy and asthma are the most prevalent chronic disorders in children and adolescents, so they need careful attention and, if necessary, an adaptation of their regular treatment plans. Fortunately, at present, young people are less suffering from COVID-19, both as incidence and severity. However, any age, including infancy, could be affected by the pandemic.Based on this background, the Italian Society of Pediatric Allergy and Immunology has felt it necessary to provide a Consensus Statement. This expert panel consensus document offers a rationale to help guide decision-making in the management of children and adolescents with allergic or immunologic diseases.
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- 2020
8. Les tests de provocation alimentaire dans 4 pays européens : France, Espagne, Italie et Royaume-Uni
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Antoine Deschildre, A. Santos, Pascal Demoly, F. Paravati, P. Rodriguez del Rio, Elena Carboni, J. Just, J. Litovsky, Davide Caimmi, E. Manca, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), and Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)
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0303 health sciences ,03 medical and health sciences ,0302 clinical medicine ,030228 respiratory system ,[SDV]Life Sciences [q-bio] ,Immunology and Allergy ,3. Good health ,030304 developmental biology - Abstract
Resume En Europe, il y a une variabilite dans les modalites de realisation de tests de provocation aux aliments dans les differents centres d’allergologie. La Societe italienne d’allergologie et immunologie pediatrique (SIAIP) a mene une enquete, dans plusieurs pays, pour evaluer les pratiques locales de realisation de ces tests et rechercher les possibles differences. Nous presentons les resultats d’un questionnaire realise sur une plateforme en ligne par 120 centres d’allergologie, distribues en 4 pays europeens differents : France, Italie, Espagne, Royaume-Uni. Malgre quelques differences, les modalites de prise en charge des patients restent assez concordantes entre les differents pays.
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- 2020
9. Should cashew and pistachio be clinically considered as one allergen?
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Elena Carboni, Maria De Filippo, Davide Caimmi, Pascal Demoly, Lucia Diaferio, Nidhal Touati, and Enrica Manca
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Pediatrics ,medicine.medical_specialty ,Allergen ,Allergy Unit ,business.industry ,Medicine ,Pediatric unit ,business ,medicine.disease_cause ,University hospital - Abstract
Should cashew and pistachio be clinically considered as one allergen?Authors (Last Name and First Name): Manca Enrica1,2, Touati Nidhal1, De Filippo Maria1,3, Carboni Elena1,4, Diaferio Lucia1,5, Demoly Pascal1,6, Caimmi Davide1,6Affiliations :1. Allergy Unit of the Department of Respiratory Diseases, University Hospital of Montpellier, France.2. Pediatric Unit, University Hospital of Foggia, Italy.3. Pediatric Unit, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Italy.4. Pediatric Unit, Ospedale Maggiore, ASST Cremona, Italy.5. Department of Pediatrics, Giovanni XXIII Hospital, Aldo Moro University of Bari, Bari, Italy.6. UMR-S 1136 INSERM-Sorbonne Universite, Equipe EPAR – IPLESP, Paris, France.Running title: Allergy to cashew and pistachio
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- 2020
10. Can pioglitazone be potentially useful therapeutically in treating patients with COVID-19?
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Anna R. Carta, Elena Carboni, and Ezio Carboni
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0301 basic medicine ,medicine.medical_specialty ,Pneumonia, Viral ,Anti-Inflammatory Agents ,Fibrin Fibrinogen Degradation Products ,03 medical and health sciences ,Betacoronavirus ,0302 clinical medicine ,Insulin resistance ,Diabetes mellitus ,Intensive care ,Internal medicine ,medicine ,Humans ,Hypoglycemic Agents ,Pandemics ,Inflammation ,Respiratory distress ,L-Lactate Dehydrogenase ,Pioglitazone ,business.industry ,Interleukin-6 ,SARS-CoV-2 ,Incidence ,COVID-19 ,General Medicine ,medicine.disease ,Prognosis ,COVID-19 Drug Treatment ,Pneumonia ,Intensive Care Units ,030104 developmental biology ,C-Reactive Protein ,Ferritins ,Hypertension ,Thiazolidinediones ,Metabolic syndrome ,Insulin Resistance ,Rosiglitazone ,business ,Coronavirus Infections ,030217 neurology & neurosurgery ,medicine.drug - Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a pandemic disease (COVID-19) that has spread globally causing more than 30,000 deaths. Despite the immense and ongoing global effort, no efficacious drugs to fight this plague have been identified and patients admitted to the intensive care units (ICU), for respiratory distress, are managed mostly by means of supportive care based on oxygen maintenance. Several authors have reported that the prevalence of hypertension, diabetes, cardiovascular and cerebrovascular diseases comorbidities were indeed frequent among patients with COVID-19, which suggests that these conditions are likely to aggravate and complicate the prognosis. What the aforementioned diseases have in common is a latent chronic inflammatory state that may be associated with the alteration of laboratory parameters that are typical of the metabolic syndrome and insulin resistance. In severe COVID-19 patients laboratory markers of inflammation such as C-reactive protein, IL-6, D-dimer, serum ferritin and lactate dehydrogenase are elevated in many patients; assessed since the 4th-6th day of illness onset, such increases seem to be predictive of an adverse prognosis. Our hypothesis is that drugs belonging to the family of thiazolidinediones (TZD) such as pioglitazone or rosiglitazone, approved for treating the condition of insulin resistance and the accompanying inflammation, could ameliorate the prognosis of those COVID-19 patients with diabetes, hypertension and cardiovascular disorders comorbidities. TZD are PPARγ agonists that act on nuclear receptors, thereby triggering certain transcription factors. TZD were widely used for type-2 diabetes in the first decade of this century and although concerns have been raised for possible side effects associated with long-term treatment, their use has been recently revaluated for their anti-inflammatory properties in numerous medical conditions.
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- 2020
11. Acute abdominal pain in an adolescent girl with an ovarian yolk sac tumor
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Ettore, Stefanelli, Valentina, Talarico, Maria, Scavone, Elena, Carboni, Giuseppe, Stranieri, Maria Concetta, Galati, Domenico, Salerno, and Giuseppe, Raiola
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Abdomen, Acute ,Ovarian Neoplasms ,alpha-fetoprotein ,Adolescent ,ovarian tumor ,Endodermal Sinus Tumor ,ovarian torsion ,Humans ,yolk sac tumor ,Female ,Case Report ,germ cell tumor - Abstract
Yolk sac tumor (YST) is a rare tumor that usually occurs in the first two decades of life. It is considered the second most common malignant germ cell tumor of the ovary, characterized by a rapid growth and a bad prognosis due to the frequent metastasis. We report the case of a 12-year-old girl who came to our observation for an acute abdominal pain. Clinical examination evidenced a vague mass in the suprapubic region and a lower abdomen tenderness, the US imaging revealed a complex lesion of the left ovary (19 x 13 cm) and the alpha-fetoprotein (AFP) resulted high (5858 ng/mL). Computed tomography (CT) revealed a large pelvic mass. The treatment consisted of debulking surgery of yolk sac tumor followed by 4 cycles of BEP protocol (Bleomycin, Etoposide, Cisplatin). After 3 years of follow-up there was no evidence of disease recurrence. (www.actabiomedica.it).
- Published
- 2019
12. Prediction of Transient or Permanent Congenital Hypothyroidism from Initial Thyroid Stimulating Hormone Levels
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Anna Vero, Giusy Romano, Elena Carboni, Roberto Miniero, Valentina Talarico, Laura Giancotti, Maria Scavone, and Ettore Stefanelli
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Male ,endocrine system ,medicine.medical_specialty ,Pediatrics ,genetic structures ,endocrine system diseases ,Remission, Spontaneous ,Thyrotropin ,030209 endocrinology & metabolism ,Decision Support Techniques ,03 medical and health sciences ,Transient hypothyroidism ,0302 clinical medicine ,Thyroid-stimulating hormone ,Pediatric surgery ,Congenital Hypothyroidism ,medicine ,Humans ,030212 general & internal medicine ,Retrospective Studies ,business.industry ,Disease progression ,Infant, Newborn ,Follow up studies ,Infant ,Retrospective cohort study ,Prognosis ,medicine.disease ,Congenital hypothyroidism ,Thyroxine ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Disease Progression ,Female ,business ,Cretinism ,Biomarkers ,hormones, hormone substitutes, and hormone antagonists ,Follow-Up Studies - Abstract
To identify factors that discriminate between transient and permanent congenital hypothyroidism.Retrospective evaluation of 58 children with congenital hypothyroidism and eutopic thyroid gland. Gender, gestational age, birth weight, TSH and serum thyroxine levels at diagnosis and L-thyroxine dose at 12 and 24 months of age were analyzed.Median (IQR) initial TSH levels were 73.3 (276.5) µIU/mL in permanent hypothyroidism and 24.24 (52.7) µU/mL in transient hypothyroidism (P =0.0132). The optimum cut-off value of initial TSH to predict transient hypothyroidism was 90 µIU/mL. Mean (SD) L-thyroxine doses at 24 months of age were 2.64 (0.98) µg/kg/day in permanent hypothyroidism and 1.91 (0.65) µg/kg/day in transient hypothyroidism. Requirement of L-thyroxine dose at 24 months of ≤0.94 µg/kg/day had the highest sensitivity (100%) to predict transient hypothyroidism.L-thyroxine doses at 24 months can predict transient hypothyroidism in patients with eutopic thyroid gland earlier than at 36 months.
- Published
- 2018
13. Il 'perché' dello skin care nella dermatite atopica
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Elena Galli, Nunzia Maiello, Giampaolo Ricci, Elisa Anastasio, Giuseppe Baviera, Lucia Caminiti, Elena Carboni, Rossella Carello, Francesca Cipriani, Iria Neri, and Elena Galli, Nunzia Maiello, Giampaolo Ricci, Elisa Anastasio, Giuseppe Baviera, Lucia Caminiti, Elena Carboni, Rossella Carello, Francesca Cipriani, Iria Neri
- Subjects
dermatite atopica, skin care, emollienti, idratanti - Abstract
È noto come la patogenesi della dermatite atopica sia determinata dall’interazione fra fattori genetici, epigenetici ed ambientali, eterogeneo spettro di difetti immunologici e numerose alterazioni della barriera e del microbioma cutaneo. Questa complessa patogenesi ci induce subito a comprendere perché attualmente non esista ancora una terapia definitiva della malattia. Il trattamento di base consiste nel cercare di raggiungere rapidamente un buon miglioramento cutaneo e un buon controllo del prurito e mantenere questa situazione “ottimale“ stabile il più a lungo possibile mediante un corretto e costante utilizzo di emollienti e detergenti specifici, il cosidetto skin care. L’utilizzo quotidiano dello skin care, consigliato da tutte le più recenti Linee Guida, rappresenta infatti un complemento indispensabile per aiutare il ripristino delle funzioni della barriera cutanea sempre altamente compromessa nella dermatite, anche in apparente fase di benessere.
- Published
- 2018
14. Puis-je consommer la pistache à la maison, en cas de tests négatifs pour la noix de cajou ?
- Author
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Nidhal Touati, M. de Filippo, Elena Carboni, Davide Caimmi, and Enrica Manca
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Immunology and Allergy - Abstract
Introduction L’allergie a la noix de cajou (NC) est associee a des reactions anaphylactiques severes. La NC montre une forte reactivite croisee avec la pistache (P), a cause d’une homologie elevee entre les proteines de stockage des deux fruits. En cas de bilan negatif pour la NC, souvent il est conseille de consommer la P a domicile, sans realiser un work-up allergique complet vis-a-vis de ce deuxieme allergene. Le but de cette etude etait de verifier la securite d’une telle prise en charge. Methodes Nous avons realise une etude retrospective, en incluant tous les patients consecutifs ayant beneficie d’un test de provocation orale (TPO) a la NC et a la P au CHU de Montpellier, entre 2005 et 2020. Nous avons evalue les resultats des tests cutanes (TC) realistes, des dosages d’IgE specifiques (P, NC et la proteine de stockage rAna o 3), des TPO, les comorbidites des patients et les sensibilisations a d’autres fruits a coque. Resultats Nous avons inclus 96 patients, dont 43 hommes (44,8 %), avec un âge median de 10 ans [8-26]. 23 patients (24,0 %) avaient un TPO positif a la NC et 16 (16,7 %) a la pistache. Sur 16 patients avec des TC negatifs pour la NC, 14 (87,5 %) avaient un TC positif pour la P, alors que sur 16 avec des TC negatifs pour la P, 9 (56,3 %) avaient un TC positif pour la NC. Parmi les 58 patients avec un TPO negatif a la NC, 2 (3,4 %) avaient un TPO positif a la P. Parmi les 66 patients avec un TPO negatif a la P, 9 (13,6 %) avaient un TPO positif a la NC. L’analyse post hoc a montre que la specificite des TC a la NC est de 73,1 % et a la P de 77,2 %. Aussi, la valeur predictive positive du TPO a la NC pour predire une allergie a la P est de 77,2 %. Discussion Les resultats de cette etude preliminaire montrent qu’il y a des divergences entre la sensibilisation et l’allergie a la NC et a la P, et qu’il n’est pas indique d’autoriser un patient non allergique a la NC a consommer la P a domicile, si les TC et les IgE sont positifs pour ce dernier allergene. Conclusion En cas de sensibilisation a NC et P, il est necessaire de realiser un TPO aux deux allergenes, avant de poser un diagnostic definitif ou d’autoriser la consommation de l’aliment a domicile.
- Published
- 2020
15. Case Report: Acute hemorrhagic edema of infancy (Seidlmayer purpura) – a dramatic presentation for a benign disease
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Giuseppe Raiola, Valentina Talarico, Stefania Zampogna, Ettore Stefanelli, Maria Scavone, Elena Carboni, and Maria Concetta Galati
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medicine.medical_specialty ,Case Report ,Hemorrhage ,Disease ,General Biochemistry, Genetics and Molecular Biology ,Seidlmayer purpura ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,children ,030225 pediatrics ,Edema ,medicine ,Humans ,General Pharmacology, Toxicology and Pharmaceutics ,Family history ,Purpura ,General Immunology and Microbiology ,leukocytoclastic vasculitis ,business.industry ,Acute hemorrhagic edema of infancy ,Infant ,Articles ,General Medicine ,medicine.disease ,Dermatology ,Trunk ,Acute Disease ,Etiology ,Vasculitis, Leukocytoclastic, Cutaneous ,Female ,medicine.symptom ,Presentation (obstetrics) ,erythematous rash ,business - Abstract
We present a case of an 11-month-old girl who was referred to our unit for an erythematous rash that appeared on the face and extremities. Personal and family history was not relevant. Laboratory tests were normal. During recovery, diameter and colour intensity of the cutaneous lesions increased, but after some weeks, lesions had a self-limited resolution without any treatment. Based on clinical and laboratory findings, a diagnosis of acute hemorrhagic edema of infancy (AHEI) was made. AHEI is a rare cutaneous leukocytoclastic vasculitis that usually affects children aged between 4 and 24 months. Etiology is unknown but almost of 75% of cases are preceded by infectious episodes, vaccinations or use of medications. In contrast to the dramatic cutaneous eruption, clinical conditions are usually optimal. Classically, AHEI is characterized by a triad of symptoms: fever, edema and purpura. Skin lesions are erythematous, annular, medallion-like, purpuric plaques that have a rapid onset and appear on the face and extremities, sparing trunk and mucosal membranes. Initially interpreted as a variant of Henoch-Schönlein purpura, now it is considered a distinct disease. In the majority of cases the disease is benign and self-limited without a visceral involvement, so a conservative approach is most often chosen.
- Published
- 2019
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