1. Effect of recombinant erythropoietin on functional activity of cultured human cells.
- Author
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Emel'yanova EA, Kosykh AV, Sukhanov YV, Vorotelyak EA, and Vasil'ev AV
- Subjects
- Cell Line, Cells, Cultured, Collagen drug effects, Epithelial Cells drug effects, Fibroblasts drug effects, Gels, Humans, In Situ Nick-End Labeling, Keratinocytes drug effects, Mesoderm cytology, Stromal Cells drug effects, Time Factors, Adipose Tissue drug effects, Apoptosis drug effects, Cell Proliferation drug effects, Erythropoietin pharmacology, Mesoderm drug effects, Recombinant Proteins pharmacology
- Abstract
We studied the effect of recombinant human erythropoietin on functional activity of skin cells in vitro. It was found that erythropoietin stimulated proliferation of mesenchymal and epithelial cells and effectively protected epidermal HaCaT cells from apoptosis. Insignificant effect of erythropoietin on contraction of collagen gel by mesenchymal cells was revealed. These findings suggest that erythropoietin can be a promising component of wound-healing preparations.
- Published
- 2012
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