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1. Development of a Mass Sensitive Quartz Crystal Microbalance (QCM)-Based DNA Biosensor Using a 50 MHz Electronic Oscillator Circuit

Author

Claude Gabrielli, Gonzalo García-Martinez, Enrique Alonso Bustabad, Hubert Perrot, Antonio Arnau Vives, Chantal Compère, Jose Fariña, Daniel Rose, Loreto Rodriguez-Pardo, Mathieu Lazerges, and Bogdan Bucur

Subjects
DNA sequence detection, quartz crystal microbalance, electronic oscillator, sensitivity, frequency noise, resolution, Chemical technology, TP1-1185
Abstract

This work deals with the design of a high sensitivity DNA sequence detector using a 50 MHz quartz crystal microbalance (QCM) electronic oscillator circuit. The oscillator circuitry is based on Miller topology, which is able to work in damping media. Calibration and experimental study of frequency noise are carried out, finding that the designed sensor has a resolution of 7.1 ng/cm2 in dynamic conditions (with circulation of liquid). Then the oscillator is proved as DNA biosensor. Results show that the system is able to detect the presence of complementary target DNAs in a solution with high selectivity and sensitivity. DNA target concentrations higher of 50 ng/mL can be detected.

Published
2011
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2. Development of a Mass Sensitive Quartz Crystal Microbalance (QCM)-Based DNA Biosensor Using a 50 MHz Electronic Oscillator Circuit

Author

Bogdan Bucur, Gonzalo García-Martinez, Enrique Alonso Bustabad, Daniel Rose, Jose Farina, Chantal Compère, Claude Gabrielli, Mathieu Lazerges, Antonio Arnau Vives, Hubert Perrot, L. Rodriguez-Pardo, Departamento de Tecnología Electrónica, Universidade de Vigo, Laboratoire Interfaces et Systèmes Electrochimiques (LISE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Service Interfaces et Capteurs (IFREMER), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), Department of Electronic Engineering [Universitat Politecnica de Valencia], Universitat Politècnica de València (UPV), and Service Interfaces et capteurs (IC)

Subjects
Genetic procedures, Analytical chemistry, 02 engineering and technology, Biosensing Techniques, frequency noise, lcsh:Chemical technology, 01 natural sciences, Biochemistry, Analytical Chemistry, quartz crystal microbalance, Sensitivity, Quartz crystal microbalance, Electrochemistry, lcsh:TP1-1185, Disulfides, DNA sequence detection, Instrumentation, Chemistry, Physics, Detector, Quartz Crystal Microbalance Techniques, 021001 nanoscience & nanotechnology, Atomic and Molecular Physics, and Optics, Reproducibility, electronic oscillator, sensitivity, resolution, Calibration, Equipment design, 0210 nano-technology, Topology (electrical circuits), Electronic oscillator, Article, TECNOLOGIA ELECTRONICA, Disulfide, Oscillometry, Electrical and Electronic Engineering, 010401 analytical chemistry, Methodology, Reproducibility of Results, DNA, 0104 chemical sciences, Frequency noise, Resolution, Electronics, [CHIM.OTHE]Chemical Sciences/Other, Sensitivity (electronics), Biosensor
Abstract

This work deals with the design of a high sensitivity DNA sequence detector using a 50 MHz quartz crystal microbalance (QCM) electronic oscillator circuit. The oscillator circuitry is based on Miller topology, which is able to work in damping media. Calibration and experimental study of frequency noise are carried out, finding that the designed sensor has a resolution of 7.1 ng/cm 2 in dynamic conditions (with circulation of liquid). Then the oscillator is proved as DNA biosensor. Results show that the system is able to detect the presence of complementary target DNAs in a solution with high selectivity and sensitivity. DNA target concentrations higher of 50 ng/mL can be detected. © 2011 by the authors; licensee MDPI, Basel, Switzerland., ANR PRECODD (HAB SEACHIP) and Erasmus Program (European Union) are gratefully acknowledged for financially supporting this research.

Published
2011
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