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2. Viral rhodopsins 1 are an unique family of light-gated cation channels

Author

Dmitrii Zabelskii, Alexey Alekseev, Kirill Kovalev, Vladan Rankovic, Taras Balandin, Dmytro Soloviov, Dmitry Bratanov, Ekaterina Savelyeva, Elizaveta Podolyak, Dmytro Volkov, Svetlana Vaganova, Roman Astashkin, Igor Chizhov, Natalia Yutin, Maksim Rulev, Alexander Popov, Ana-Sofia Eria-Oliveira, Tatiana Rokitskaya, Thomas Mager, Yuri Antonenko, Riccardo Rosselli, Grigoriy Armeev, Konstantin Shaitan, Michel Vivaudou, Georg Büldt, Andrey Rogachev, Francisco Rodriguez-Valera, Mikhail Kirpichnikov, Tobias Moser, Andreas Offenhäusser, Dieter Willbold, Eugene Koonin, Ernst Bamberg, and Valentin Gordeliy

Subjects
Science
Abstract

Nucleocytoplasmic Large DNA Viruses (NCLDV) that infect algae encode two distinct families of microbial rhodopsins. Here, the authors characterise two proteins form the viral rhodopsin group 1 OLPVR1 and VirChR1, present the 1.4 Å crystal structure of OLPVR1 and show that viral rhodopsins 1 are light-gated cation channels.

Published
2020
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3. Hijacking of internal calcium dynamics by intracellularly residing rhodopsins

Author

Eria-Oliveira, Ana-Sofia, primary, Folacci, Mathilde, additional, Chassot, Anne Amandine, additional, Fedou, Sandrine, additional, Theze, Nadine, additional, Zabelskii, Dmitrii, additional, Alekseev, Alexey, additional, Bamberg, Ernst, additional, Gordeliy, Valentin, additional, Sandoz, Guillaume, additional, and Vivaudou, Michel, additional

Published
2023
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4. Hijacking of internal calcium dynamics by intracellularly residing rhodopsins

Author

Ana-Sofia Eria-Oliveira, Mathilde Folacci, Anne Amandine Chassot, Sandrine Fedou, Nadine Thézé, Dmitrii Zabelskii, Alexey Alekseev, Ernst Bamberg, Valentin Gordeliy, Guillaume Sandoz, and Michel Vivaudou

Abstract

Rhodopsins are ubiquitous light-driven membrane proteins with diverse functions, including ion transport. Widely distributed, they are also coded in the genomes of giant viruses infecting phytoplankton where their function is not settled. We examined the properties of three type 1 viral channelrhodopsins (VCR1s), and, unexpectedly, found that VCR1s accumulate exclusively intracellularly, and, upon illumination, induced calcium release from intracellular IP3-dependent stores. In vivo, this light-induced calcium release was sufficient to remote control muscle contraction and behavior in VCR1-expressing tadpoles. VCR1s are the first rhodopsins shown to natively confer light-induced Ca2+release, suggesting an original mechanism for reshaping the response to light of virus-infected algae. The ability of VCR1s to photorelease calcium without altering plasma membrane electrical properties marks them as precursors for novel optogenetics tools, with potential applications in basic research and medicine.

Published
2023
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5. Viral rhodopsins 1 are an unique family of light-gated cation channels

Author

Zabelskii, Dmitrii, primary, Alekseev, Alexey, additional, Kovalev, Kirill, additional, Rankovic, Vladan, additional, Balandin, Taras, additional, Soloviov, Dmytro, additional, Bratanov, Dmitry, additional, Savelyeva, Ekaterina, additional, Podolyak, Elizaveta, additional, Volkov, Dmytro, additional, Vaganova, Svetlana, additional, Astashkin, Roman, additional, Chizhov, Igor, additional, Yutin, Natalia, additional, Rulev, Maksim, additional, Popov, Alexander, additional, Eria-Oliveira, Ana-Sofia, additional, Rokitskaya, Tatiana, additional, Mager, Thomas, additional, Antonenko, Yuri, additional, Rosselli, Riccardo, additional, Armeev, Grigoriy, additional, Shaitan, Konstantin, additional, Vivaudou, Michel, additional, Büldt, Georg, additional, Rogachev, Andrey, additional, Rodriguez-Valera, Francisco, additional, Kirpichnikov, Mikhail, additional, Moser, Tobias, additional, Offenhäusser, Andreas, additional, Willbold, Dieter, additional, Koonin, Eugene, additional, Bamberg, Ernst, additional, and Gordeliy, Valentin, additional

Published
2020
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6. Viral rhodopsins 1 are an unique family of light-gated cation channels

Author

Zabelskii, Dmitrii, Alekseev, Alexey, Kovalev, Kirill, Rankovic, Vladan, Balandin, Taras, Soloviov, Dmytro, Bratanov, Dmitry, Savelyeva, Ekaterina, Podolyak, Elizaveta, Volkov, Dmytro, Vaganova, Svetlana, Astashkin, Roman, Chizhov, Igor, Yutin, Natalia, Rulev, Maksim, Popov, Alexander, Eria-Oliveira, Ana-Sofia, Rokitskaya, Tatiana, Mager, Thomas, Antonenko, Yuri, Rosselli, Riccardo, Armeev, Grigoriy, Shaitan, Konstantin, Vivaudou, Michel, Büldt, Georg, Rogachev, Andrey, Rodriguez-Valera, Francisco, Kirpichnikov, Mikhail, Moser, Tobias, Offenhäusser, Andreas, Willbold, Dieter, Koonin, Eugene, Bamberg, Ernst, and Gordeliy, Valentin

Subjects
ddc:500
Abstract

Nature Communications 11(1), 5707 (2020). doi:10.1038/s41467-020-19457-7, Published by Nature Publishing Group UK, [London]

Published
2020
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