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1. Age-related reduction in motor adaptation: brain structural correlates and the role of explicit memory

Author

Tyler, Lorraine K., Brayne, Carol, Bullmore, Edward T., Calder, Andrew C., Cusack, Rhodri, Dalgleish, Tim, Duncan, John, Matthews, Fiona E., Marslen-Wilson, William D., Shafto, Meredith A., Campbell, Karen, Cheung, Teresa, Davis, Simon, Geerligs, Linda, Kievit, Rogier, McCarrey, Anna, Mustafa, Abdur, Price, Darren, Samu, David, Taylor, Jason R., Treder, Matthias, van Belle, Janna, Williams, Nitin, Bates, Lauren, Emery, Tina, Erzinçlioglu, Sharon, Gadie, Andrew, Gerbase, Sofia, Georgieva, Stanimira, Hanley, Claire, Parkin, Beth, Troy, David, Auer, Tibor, Correia, Marta, Gao, Lu, Green, Emma, Henriques, Rafael, Allen, Jodie, Amery, Gillian, Amunts, Liana, Barcroft, Anne, Castle, Amanda, Dias, Cheryl, Dowrick, Jonathan, Fair, Melissa, Fisher, Hayley, Goulding, Anna, Grewal, Adarsh, Hale, Geoff, Hilton, Andrew, Johnson, Frances, Johnston, Patricia, Kavanagh-Williamson, Thea, Kwasniewska, Magdalena, McMinn, Alison, Norman, Kim, Penrose, Jessica, Roby, Fiona, Rowland, Diane, Sargeant, John, Squire, Maggie, Stevens, Beth, Stoddart, Aldabra, Stone, Cheryl, Thompson, Tracy, Yazlik, Ozlem, Barnes, Dan, Dixon, Marie, Hillman, Jaya, Mitchell, Joanne, Villis, Laura, Wolpe, Noham, Ingram, James N., Tsvetanov, Kamen A., Henson, Richard N., Wolpert, Daniel M., and Rowe, James B.

Published
2020
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4. Idiosyncratic responding during movie-watching predicted by age differences in attentional control

Author

Tyler, Lorraine K., Brayne, Carol, Bullmore, Ed, Calder, Andrew, Cusack, Rhodri, Dalgleish, Tim, Duncan, John, Henson, Rik, Matthews, Fiona, Marslen-Wilson, William, Rowe, James, Shafto, Meredith, Campbell, Karen, Cheung, Teresa, Davis, Simon, Geerligs, Linda, Kievit, Rogier, McCarrey, Anna, Price, Darren, Taylor, Jason, Tsvetanov, Kamen, Williams, Nitin, Bates, Lauren, Emery, Tina, Erzinçlioglu, Sharon, Gadie, Andrew, Gerbase, Sofia, Georgieva, Stanimira, Hanley, Claire, Parkin, Beth, Troy, David, Allen, Jodie, Amery, Gillian, Amunts, Liana, Barcroft, Anne, Castle, Amanda, Dias, Cheryl, Dowrick, Jonathan, Fair, Melissa, Fisher, Hayley, Goulding, Anna, Grewal, Adarsh, Hale, Geoff, Hilton, Andrew, Johnson, Frances, Johnston, Patricia, Kavanagh-Williamson, Thea, Kwasniewska, Magdalena, McMinn, Alison, Norman, Kim, Penrose, Jessica, Roby, Fiona, Rowland, Diane, Sargeant, John, Squire, Maggie, Stevens, Beth, Stoddart, Aldabra, Stone, Cheryl, Thompson, Tracy, Yazlik, Ozlem, Dixon, Marie, Barnes, Dan, Hillman, Jaya, Mitchell, Joanne, Villis, Laura, Campbell, Karen L., Shafto, Meredith A., Wright, Paul, and Tsvetanov, Kamen A.

Published
2015
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5. Distinct components of cardiovascular health are linked with age-related differences in cognitive abilities

Author

King, Deborah LO, Henson, Richard N, Kievit, Rogier, Wolpe, Noham, Brayne, Carol, Tyler, Lorraine K, Rowe, James B, Bullmore, Edward T, Calder, Andrew C, Cusack, Rhodri, Dalgleish, Tim, Duncan, John, Matthews, Fiona E, Marslen-Wilson, William D, Shafto, Meredith A, Campbell, Karen, Cheung, Teresa, Davis, Simon, Geerligs, Linda, McCarrey, Anna, Mustafa, Abdur, Price, Darren, Samu, David, Taylor, Jason R, Treder, Matthias, van Belle, Janna, Williams, Nitin, Mitchell, Daniel, Fisher, Simon, Eising, Else, Knights, Ethan, Bates, Lauren, Emery, Tina, Erzinçlioglu, Sharon, Gadie, Andrew, Gerbase, Sofia, Georgieva, Stanimira, Hanley, Claire, Parkin, Beth, Troy, David, Auer, Tibor, Correia, Marta, Gao, Lu, Green, Emma, Henriques, Rafael, Allen, Jodie, Amery, Gillian, Amuntse, Liana, Barcroft, Anne, Castle, Amanda, Dias, Cheryl, Dowrick, Jonathan, Fair, Melissa, Fisher, Hayley, Goulding, Anna, Grewale, Adarsh, Hale, Geoff, Hilton, Andrew, Johnson, Frances, Johnston, Patricia, Kavanagh-Williamson, Thea, Kwasniewska, Magdalena, McMinn, Alison, Norman, Kim, Penrose, Jessica, Roby, Fiona, Rowland, Diane, Sargeant, John, Squire, Maggie, Stevens, Beth, Stoddart, Aldabra, Stone, Cheryl, Thompson, Tracy, Yazlik, Ozlem, Barnes, Dan, Dixon, Marie, Hillman, Jaya, Mitchell, Joanne, Villis, Laura, Tsvetanov, Kamen A, and Apollo - University of Cambridge Repository

Subjects
692/4019/592, 631/378/2612, article, 692/499
Abstract

Cardiovascular ageing contributes to cognitive impairment. However, the unique and synergistic contributions of multiple cardiovascular factors to cognitive function remain unclear because they are often condensed into a single composite score or examined in isolation. We hypothesized that vascular risk factors, electrocardiographic features and blood pressure indices reveal multiple latent vascular factors, with independent contributions to cognition. In a population-based deep-phenotyping study (n = 708, age 18–88), path analysis revealed three latent vascular factors dissociating the autonomic nervous system response from two components of blood pressure. These three factors made unique and additive contributions to the variability in crystallized and fluid intelligence. The discrepancy in fluid relative to crystallized intelligence, indicative of cognitive decline, was associated with a latent vascular factor predominantly expressing pulse pressure. This suggests that higher pulse pressure is associated with cognitive decline from expected performance. The effect was stronger in older adults. Controlling pulse pressure may help to preserve cognition, particularly in older adults. Our findings highlight the need to better understand the multifactorial nature of vascular aging.

Published
2023
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6. Noradrenergic-dependent functions are associated with age-related locus coeruleus signal intensity differences

Author

Liu, Kathy Y., Kievit, Rogier A., Tsvetanov, Kamen A., Betts, Matthew J., Düzel, Emrah, Rowe, James B., Howard, Robert, Hämmerer, Dorothea, Tyler, Lorraine K., Brayne, Carol, Bullmore, Edward T., Calder, Andrew C., Cusack, Rhodri, Dalgleish, Tim, Duncan, John, Henson, Richard N., Matthews, Fiona E., Marslen-Wilson, William D., Shafto, Meredith A., Campbell, Karen, Cheung, Teresa, Davis, Simon, Geerligs, Linda, Kievit, Rogier, McCarrey, Anna, Mustafa, Abdur, Price, Darren, Samu, David, Taylor, Jason R., Treder, Matthias, Belle, Janna Van, Williams, Nitin, Bates, Lauren, Emery, Tina, Erzinçlioglu, Sharon, Gadie, Andrew, Gerbase, Sofia, Georgieva, Stanimira, Hanley, Claire, Parkin, Beth, Troy, David, Auer, Tibor, Correia, Marta, Gao, Lu, Green, Emma, Henriques, Rafael, Allen, Jodie, Amery, Gillian, Amunts, Liana, Barcroft, Anne, Castle, Amanda, Dias, Cheryl, Dowrick, Jonathan, Fair, Melissa, Fisher, Hayley, Goulding, Anna, Grewal, Adarsh, Hale, Geoff, Hilton, Andrew, Johnson, Frances, Johnston, Patricia, Kavanagh-Williamson, Thea, Kwasniewska, Magdalena, McMinn, Alison, Norman, Kim, Penrose, Jessica, Roby, Fiona, Rowland, Diane, Sargeant, John, Squire, Maggie, Stevens, Beth, Stoddart, Aldabra, Stone, Cheryl, Thompson, Tracy, Yazlik, Ozlem, Barnes, Dan, Dixon, Marie, Hillman, Jaya, Mitchell, Joanne, Villis, Laura, Liu, Kathy Y. [0000-0002-7482-2758], Kievit, Rogier A. [0000-0003-0700-4568], and Apollo - University of Cambridge Repository

Subjects
631/378/2649, 631/378/2612, article
Abstract

The locus coeruleus (LC), the origin of noradrenergic modulation of cognitive and behavioral function, may play an important role healthy ageing and in neurodegenerative conditions. We investigated the functional significance of age-related differences in mean normalized LC signal intensity values (LC-CR) in magnetization-transfer (MT) images from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) cohort - an open-access, population-based dataset. Using structural equation modelling, we tested the pre-registered hypothesis that putatively noradrenergic (NA)-dependent functions would be more strongly associated with LC-CR in older versus younger adults. A unidimensional model (within which LC-CR related to a single factor representing all cognitive and behavioral measures) was a better fit with the data than the a priori two-factor model (within which LC-CR related to separate NA-dependent and NA-independent factors). Our findings support the concept that age-related reduction of LC structural integrity is associated with impaired cognitive and behavioral function.

Published
2021
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7. Age-related reduction in motor adaptation: brain structural correlates and the role of explicit memory

Author

Wolpe, Noham, primary, Ingram, James N., additional, Tsvetanov, Kamen A., additional, Henson, Richard N., additional, Wolpert, Daniel M., additional, Rowe, James B., additional, Tyler, Lorraine K., additional, Brayne, Carol, additional, Bullmore, Edward T., additional, Calder, Andrew C., additional, Cusack, Rhodri, additional, Dalgleish, Tim, additional, Duncan, John, additional, Matthews, Fiona E., additional, Marslen-Wilson, William D., additional, Shafto, Meredith A., additional, Campbell, Karen, additional, Cheung, Teresa, additional, Davis, Simon, additional, Geerligs, Linda, additional, Kievit, Rogier, additional, McCarrey, Anna, additional, Mustafa, Abdur, additional, Price, Darren, additional, Samu, David, additional, Taylor, Jason R., additional, Treder, Matthias, additional, van Belle, Janna, additional, Williams, Nitin, additional, Bates, Lauren, additional, Emery, Tina, additional, Erzinçlioglu, Sharon, additional, Gadie, Andrew, additional, Gerbase, Sofia, additional, Georgieva, Stanimira, additional, Hanley, Claire, additional, Parkin, Beth, additional, Troy, David, additional, Auer, Tibor, additional, Correia, Marta, additional, Gao, Lu, additional, Green, Emma, additional, Henriques, Rafael, additional, Allen, Jodie, additional, Amery, Gillian, additional, Amunts, Liana, additional, Barcroft, Anne, additional, Castle, Amanda, additional, Dias, Cheryl, additional, Dowrick, Jonathan, additional, Fair, Melissa, additional, Fisher, Hayley, additional, Goulding, Anna, additional, Grewal, Adarsh, additional, Hale, Geoff, additional, Hilton, Andrew, additional, Johnson, Frances, additional, Johnston, Patricia, additional, Kavanagh-Williamson, Thea, additional, Kwasniewska, Magdalena, additional, McMinn, Alison, additional, Norman, Kim, additional, Penrose, Jessica, additional, Roby, Fiona, additional, Rowland, Diane, additional, Sargeant, John, additional, Squire, Maggie, additional, Stevens, Beth, additional, Stoddart, Aldabra, additional, Stone, Cheryl, additional, Thompson, Tracy, additional, Yazlik, Ozlem, additional, Barnes, Dan, additional, Dixon, Marie, additional, Hillman, Jaya, additional, Mitchell, Joanne, additional, and Villis, Laura, additional

Published
2020
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8. Perceptual and conceptual processing of visual objects across the adult lifespan

Author

Bruffaerts, Rose, Tyler, Lorraine K., Shafto, Meredith, Tsvetanov, Kamen A., Clarke, Alex, Brayne, Carol, Bullmore, Edward T., Calder, Andrew C., Cusack, Rhodri, Dalgleish, Tim, Duncan, John, Henson, Richard N., Matthews, Fiona E., Marslen-Wilson, William D., Rowe, James B., Campbell, Karen, Cheung, Teresa, Davis, Simon, Geerligs, Linda, Kievit, Rogier, McCarrey, Anna, Mustafa, Abdur, Price, Darren, Samu, David, Taylor, Jason R., Treder, Matthias, Van Belle, Janna, Williams, Nitin, Bates, Lauren, Emery, Tina, Erzinçlioglu, Sharon, Gadie, Andrew, Gerbase, Sofia, Georgieva, Stanimira, Hanley, Claire, Parkin, Beth, Troy, David, Auer, Tibor, Correia, Marta, Gao, Lu, Green, Emma, Henriques, Rafael, Allen, Jodie, Amery, Gillian, Amunts, Liana, Barcroft, Anne, Castle, Amanda, Dias, Cheryl, Dowrick, Jonathan, Fair, Melissa, Fisher, Hayley, Goulding, Anna, Grewal, Adarsh, Hale, Geoff, Hilton, Andrew, Johnson, Frances, Johnston, Patricia, Kavanagh-Williamson, Thea, Kwasniewska, Magdalena, McMinn, Alison, Norman, Kim, Penrose, Jessica, Roby, Fiona, Rowland, Diane, Sargeant, John, Squire, Maggie, Stevens, Beth, Stoddart, Aldabra, Stone, Cheryl, Thompson, Tracy, Yazlik, Ozlem, Barnes, Dan, Dixon, Marie, Hillman, Jaya, Mitchell, Joanne, Villis, Laura, Clarke, Alex [0000-0001-7768-5229], and Apollo - University of Cambridge Repository

Subjects
Male, DYNAMICS, 123, Visual Physiology, lcsh:Medicine, 631/378/2649/1723, Visual processing, 0302 clinical medicine, Cognition, Visual Objects, lcsh:Science, Language, computer.programming_language, media_common, Aged, 80 and over, Multidisciplinary, medicine.diagnostic_test, 05 social sciences, Cognitive neuroscience of visual object recognition, article, Brain, Middle Aged, STATISTICS, STATE, Semantics, Multidisciplinary Sciences, Pattern Recognition, Visual, 9, Visual Perception, Science & Technology - Other Topics, Female, Psychology, Cognitive psychology, Adult, media_common.quotation_subject, Longevity, 050105 experimental psychology, AGE-RELATED-CHANGES, 03 medical and health sciences, Young Adult, Perception, medicine, Humans, 0501 psychology and cognitive sciences, KNOWLEDGE, SPEED, Aged, Science & Technology, lcsh:R, RECOGNITION, Magnetoencephalography, 631/378/2649/1594, COGNITION, lcsh:Q, 119, computer, 030217 neurology & neurosurgery, RESPONSES
Abstract

Making sense of the external world is vital for multiple domains of cognition, and so it is crucial that object recognition is maintained across the lifespan. We investigated age differences in perceptual and conceptual processing of visual objects in a population-derived sample of 85 healthy adults (24-87 years old) by relating measures of object processing to cognition across the lifespan. Magnetoencephalography (MEG) was recorded during a picture naming task to provide a direct measure of neural activity, that is not confounded by age-related vascular changes. Multiple linear regression was used to estimate neural responsivity for each individual, namely the capacity to represent visual or semantic information relating to the pictures. We find that the capacity to represent semantic information is linked to higher naming accuracy, a measure of task-specific performance. In mature adults, the capacity to represent semantic information also correlated with higher levels of fluid intelligence, reflecting domain-general performance. In contrast, the latency of visual processing did not relate to measures of cognition. These results indicate that neural responsivity measures relate to naming accuracy and fluid intelligence. We propose that maintaining neural responsivity in older age confers benefits in task-related and domain-general cognitive processes, supporting the brain maintenance view of healthy cognitive ageing. ispartof: SCIENTIFIC REPORTS vol:9 issue:1 ispartof: location:England status: published

Published
2019

9. Exploring patterns of response across the lifespan: the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) study

Author

Green, Emma, Bennett, Holly, Brayne, Carol, Tyler, Lorraine K., Bullmore, Edward T., Calder, Andrew C., Cusack, Rhodri, Dalgleish, Tim, Duncan, John, Henson, Richard N., Marslen-Wilson, William D., Rowe, James B., Shafto, Meredith A., Campbell, Karen, Cheung, Teresa, Davis, Simon, Geerligs, Linda, Kievit, Rogier, McCarrey, Anna, Mustafa, Abdur, Price, Darren, Samu, David, Taylor, Jason R., Treder, Matthias, Tsvetanov, Kamen, Van Belle, Janna, Williams, Nitin, Bates, Lauren, Emery, Tina, Erzinçlioglu, Sharon, Gadie, Andrew, Gerbase, Sofia, Georgieva, Stanimira, Hanley, Claire, Parkin, Beth, Troy, David, Auer, Tibor, Correia, Marta, Gao, Lu, Henriques, Rafael, Allen, Jodie, Amery, Gillian, Amunts, Liana, Barcroft, Anne, Castle, Amanda, Dias, Cheryl, Dowrick, Jonathan, Fair, Melissa, Fisher, Hayley, Goulding, Anna, Cam-CAN, Green, Emma [0000-0002-8687-5590], and Apollo - University of Cambridge Repository

Subjects
Male, medicine.medical_specialty, ResearchInstitutes_Networks_Beacons/MICRA, Epidemiological study, Population, Logistic regression, Affect (psychology), Non-participation, Cohort Studies, 03 medical and health sciences, Cognition, 0302 clinical medicine, Surveys and Questionnaires, Epidemiology, medicine, Humans, 030212 general & internal medicine, education, Aged, education.field_of_study, Lifespan, business.industry, lcsh:Public aspects of medicine, Age Factors, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, Odds ratio, Middle Aged, United Kingdom, Middle age, Ageing, Epidemiologic Studies, Cross-Sectional Studies, Manchester Institute for Collaborative Research on Ageing, Cohort, Female, Biostatistics, business, Neuroscience, 030217 neurology & neurosurgery, Research Article
Abstract

Background With declining rates of participation in epidemiological studies there is an important need to attempt to understand what factors might affect response. This study examines the pattern of response at different adult ages within a contemporary cross-sectional population-based cohort, the Cambridge Centre for Ageing and Neuroscience (Cam-CAN). Methods Using logistic regression, we investigated associations between age, gender and Townsend deprivation level for both participants and non-participants. Weighted estimates of the odds ratios with confidence intervals for each demographic characteristic were calculated. Reasons given for refusal were grouped into three broad categories: ‘active’, ‘passive’ and illness preventing interview. Results An association of age and participation was found, with individuals in middle age groups more likely to participate (age group 48–57 OR: 1.8, 95% CI: 1.5–2.2 and age group 58–67 OR: 2.1, 95% CI: 1.7–2.4). Overall, there was no difference in participation between men and women. An association with deprivation was found, with those living in the most deprived areas being the least willing to participate (fifth quintile OR: 0.6, 95% CI: 0.5–0.7). An interaction between age and gender was found whereby younger women and older men were more likely to agree to participate (p = 0.01). Conclusion Our findings highlight some of the factors affecting recruitment into epidemiological studies in the UK and suggest that targeted age-specific recruitment strategies might be needed to increase participation rates in future cohort investigations. Electronic supplementary material The online version of this article (10.1186/s12889-018-5663-7) contains supplementary material, which is available to authorized users.

Published
2018
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10. Ageing increases reliance on sensorimotor prediction through structural and functional differences in frontostriatal circuits

Author

Wolpe, Noham, Ingram, James N., Tsvetanov, Kamen A., Geerligs, Linda, Kievit, Rogier A., Henson, Richard N., Wolpert, Daniel M., Tyler, Lorraine K., Brayne, Carol, Bullmore, Edward, Calder, Andrew, Cusack, Rhodri, Dalgleish, Tim, Duncan, John, Matthews, Fiona E., Marslen-Wilson, William, Shafto, Meredith A., Campbell, Karen, Cheung, Teresa, Davis, Simon, McCarrey, Anna, Mustafa, Abdur, Price, Darren, Samu, David, Taylor, Jason R., Treder, Matthias, van Belle, Janna, Williams, Nitin, Bates, Lauren, Emery, Tina, Erzinçlioglu, Sharon, Gadie, Andrew, Gerbase, Sofia, Georgieva, Stanimira, Hanley, Claire, Parkin, Beth, Troy, David, Auer, Tibor, Correia, Marta, Gao, Lu, Green, Emma, Henriques, Rafael, Allen, Jodie, Amery, Gillian, Amunts, Liana, Barcroft, Anne, Castle, Amanda, Dias, Cheryl, Dowrick, Jonathan, Fair, Melissa, Fisher, Hayley, Goulding, Anna, Grewal, Adarsh, Hale, Geoff, Hilton, Andrew, Johnson, Frances, Johnston, Patricia, Kavanagh-Williamson, Thea, Kwasniewska, Magdalena, McMinn, Alison, Norman, Kim, Penrose, Jessica, Roby, Fiona, Rowland, Diane, Sargeant, John, Squire, Maggie, Stevens, Beth, Stoddart, Aldabra, Stone, Cheryl, Thompson, Tracy, Yazlik, Ozlem, Barnes, Dan, Dixon, Marie, Hillman, Jaya, Mitchell, Joanne, Villis, Laura, and Rowe, James B.

Published
2016

11. Idiosyncratic responding during movie-watching predicted by age differences in attentional control

Author

Campbell, Karen L., primary, Shafto, Meredith A., additional, Wright, Paul, additional, Tsvetanov, Kamen A., additional, Geerligs, Linda, additional, Cusack, Rhodri, additional, Tyler, Lorraine K., additional, Brayne, Carol, additional, Bullmore, Ed, additional, Calder, Andrew, additional, Dalgleish, Tim, additional, Duncan, John, additional, Henson, Rik, additional, Matthews, Fiona, additional, Marslen-Wilson, William, additional, Rowe, James, additional, Shafto, Meredith, additional, Campbell, Karen, additional, Cheung, Teresa, additional, Davis, Simon, additional, Kievit, Rogier, additional, McCarrey, Anna, additional, Price, Darren, additional, Taylor, Jason, additional, Tsvetanov, Kamen, additional, Williams, Nitin, additional, Bates, Lauren, additional, Emery, Tina, additional, Erzinçlioglu, Sharon, additional, Gadie, Andrew, additional, Gerbase, Sofia, additional, Georgieva, Stanimira, additional, Hanley, Claire, additional, Parkin, Beth, additional, Troy, David, additional, Allen, Jodie, additional, Amery, Gillian, additional, Amunts, Liana, additional, Barcroft, Anne, additional, Castle, Amanda, additional, Dias, Cheryl, additional, Dowrick, Jonathan, additional, Fair, Melissa, additional, Fisher, Hayley, additional, Goulding, Anna, additional, Grewal, Adarsh, additional, Hale, Geoff, additional, Hilton, Andrew, additional, Johnson, Frances, additional, Johnston, Patricia, additional, Kavanagh-Williamson, Thea, additional, Kwasniewska, Magdalena, additional, McMinn, Alison, additional, Norman, Kim, additional, Penrose, Jessica, additional, Roby, Fiona, additional, Rowland, Diane, additional, Sargeant, John, additional, Squire, Maggie, additional, Stevens, Beth, additional, Stoddart, Aldabra, additional, Stone, Cheryl, additional, Thompson, Tracy, additional, Yazlik, Ozlem, additional, Dixon, Marie, additional, Barnes, Dan, additional, Hillman, Jaya, additional, Mitchell, Joanne, additional, and Villis, Laura, additional

Published
2015
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14. Multiple determinants of lifespan memory differences

Author

Henson, Richard N., Campbell, Karen L., Davis, Simon W., Taylor, Jason R., Emery, Tina, Erzinclioglu, Sharon, Tyler, Lorraine K., Brayne, Carol, Bullmore, Edward T., Calder, Andrew C., Cusack, Rhodri, Dalgleish, Tim, Duncan, John, Matthews, Fiona E., Marslen-Wilson, William D., Rowe, James B., Shafto, Meredith A., Cheung, Teresa, Geerligs, Linda, McCarrey, Anna, Mustafa, Abdur, Price, Darren, Samu, David, Treder, Matthias, Tsvetanov, Kamen A., van Belle, Janna, Williams, Nitin, Bates, Lauren, Gadie, Andrew, Gerbase, Sofia, Georgieva, Stanimira, Hanley, Claire, Parkin, Beth, Troy, David, Auer, Tibor, Correia, Marta, Gao, Lu, Green, Emma, Henriques, Rafael, Allen, Jodie, Amery, Gillian, Amunts, Liana, Barcroft, Anne, Castle, Amanda, Dias, Cheryl, Dowrick, Jonathan, Fair, Melissa, Fisher, Hayley, Goulding, Anna, Grewa, Adarsh, Hale, Geoff, Hilton, Andrew, Johnson, Frances, Johnston, Patricia, Kavanagh-Williamson, Thea, Kwasniewska, Magdalena, McMinn, Alison, Norman, Kim, Penrose, Jessica, Roby, Fiona, Rowland, Diane, Sargeant, John, Squire, Maggie, Stevens, Beth, Stoddart, Aldabra, Stone, Cheryl, Thompson, Tracy, Yazlik, Ozlem, Barnes, Dan, Dixon, Marie, Hillman, Jaya, Mitchell, Joanne, Villis, Laura, and Kievit, Rogier A.

Abstract

Memory problems are among the most common complaints as people grow older. Using structural equation modeling of commensurate scores of anterograde memory from a large (N = 315), population-derived sample (www.cam-can.org), we provide evidence for three memory factors that are supported by distinct brain regions and show differential sensitivity to age. Associative memory and item memory are dramatically affected by age, even after adjusting for education level and fluid intelligence, whereas visual priming is not. Associative memory and item memory are differentially affected by emotional valence, and the age-related decline in associative memory is faster for negative than for positive or neutral stimuli. Gray-matter volume in the hippocampus, parahippocampus and fusiform cortex, and a white-matter index for the fornix, uncinate fasciculus and inferior longitudinal fasciculus, show differential contributions to the three memory factors. Together, these data demonstrate the extent to which differential ageing of the brain leads to differential patterns of memory loss.

Published
2016
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15. Idiosyncratic responding during movie-watching predicted by age differences in attentional control

Author

Campbell, Karen L., Shafto, Meredith A., Wright, Paul, Tsvetanov, Kamen A., Geerligs, Linda, Cusack, Rhodri, Tyler, Lorraine K., Brayne, Carol, Bullmore, Ed, Calder, Andrew, Dalgleish, Tim, Duncan, John, Henson, Rik, Matthews, Fiona, Marslen-Wilson, William, Rowe, James, Shafto, Meredith, Campbell, Karen, Cheung, Teresa, Davis, Simon, Kievit, Rogier, McCarrey, Anna, Price, Darren, Taylor, Jason, Tsvetanov, Kamen, Williams, Nitin, Bates, Lauren, Emery, Tina, Erzinçlioglu, Sharon, Gadie, Andrew, Gerbase, Sofia, Georgieva, Stanimira, Hanley, Claire, Parkin, Beth, Troy, David, Allen, Jodie, Amery, Gillian, Amunts, Liana, Barcroft, Anne, Castle, Amanda, Dias, Cheryl, Dowrick, Jonathan, Fair, Melissa, Fisher, Hayley, Goulding, Anna, Grewal, Adarsh, Hale, Geoff, Hilton, Andrew, Johnson, Frances, Johnston, Patricia, Kavanagh-Williamson, Thea, Kwasniewska, Magdalena, McMinn, Alison, Norman, Kim, Penrose, Jessica, Roby, Fiona, Rowland, Diane, Sargeant, John, Squire, Maggie, Stevens, Beth, Stoddart, Aldabra, Stone, Cheryl, Thompson, Tracy, Yazlik, Ozlem, Dixon, Marie, Barnes, Dan, Hillman, Jaya, Mitchell, Joanne, and Villis, Laura

Subjects
Intersubject correlation, Ageing, Aging, Neuroscience(all), fMRI, Independent components analysis, Clinical Neurology, Natural vision, Geriatrics and Gerontology, Developmental Biology, Attentional control
Abstract

Much is known about how age affects the brain during tightly controlled, though largely contrived, experiments, but do these effects extrapolate to everyday life? Naturalistic stimuli, such as movies, closely mimic the real world and provide a window onto the brain's ability to respond in a timely and measured fashion to complex, everyday events. Young adults respond to these stimuli in a highly synchronized fashion, but it remains to be seen how age affects neural responsiveness during naturalistic viewing. To this end, we scanned a large (N = 218), population-based sample from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) during movie-watching. Intersubject synchronization declined with age, such that older adults' response to the movie was more idiosyncratic. This decreased synchrony related to cognitive measures sensitive to attentional control. Our findings suggest that neural responsivity changes with age, which likely has important implications for real-world event comprehension and memory.

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