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1. Risk assessment of contaminants in food and feed

Author

Alexander J, Benford D, Boobis A, Eskola M, Fink-Gremmels J, Fürst P, Heppner C, Schlatter J, and van Leeuwen R

Subjects
CONTAM Panel, risk assessment, contaminants, human health, animal health, Nutrition. Foods and food supply, TX341-641, Chemical technology, TP1-1185
Abstract

The EFSA Panel on Contaminants in the Food Chain (CONTAM Panel) carries out risk assessment on contaminants in food and feed. The presence of hazardous chemical contaminants or undesirable substances in food and feed is often unavoidable as these substances may occur ubiquitously or are of natural origin. Therefore, human and animal exposure to such substances is also unavoidable. The task of the CONTAM Panel is to assess whether or not exposure to a chemical contaminant in food is likely to be associated with adverse health effects in the European population. Similarly, the Panel assesses if the exposure to a contaminant in feed is likely to be associated with adverse health effects in farm animals, fish and pets in Europe, or to represent a risk to the consumer of foods of animal origin. In contrast to EFSA Panels dealing with regulated substances where inter alia applications are taken into account, the CONTAM Panel relies on scientific information that is in the public domain. EFSA often launches calls for data on occurrence of contaminants in food and feedstuffs where Member States and other interested stakeholders are invited to submit data. Whenever possible and required the CONTAM Panel establishes for a substance a health-based guidance value such as tolerable daily intake. For substances that are both genotoxic and carcinogenic, or for which the data are inadequate to establish a health-based guidance value, the margin of exposure approach is used. Recently the CONTAM Panel also used the threshold of toxicological concern approach. In addition, the CONTAM Panel considers inherent uncertainties in relation to objectives, exposure and hazard characterisation in its risk assessments. During 2003-2012, the CONTAM Panel published 107 scientific outputs (55 on food, 43 on feed, 9 on food and feed).

Published
2012
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3. Perioperative bleeding requiring blood transfusions is associated with increased risk of stroke after transcatheter and surgical aortic valve replacement

Author

Tauriainen, T. (Tuomas), Juvonen, T. (Tatu), Anttila, V. (Vesa), Maaranen, P. (Pasi), Niemelä, M. (Matti), Eskola, M. (Markku), Ahvenvaara, T. (Tuomas), Husso, A. (Annastiina), Virtanen, M. P. (Marko P.O.), Kinnunen, E.-M. (Eeva-Maija), Dahlbacka, S. (Sebastian), Jalava, M. (Maina), Laine, M. (Mika), Valtola, A. (Antti), Raivio, P. (Peter), Vento, A. (Antti), Airaksinen, J. (Juhani), Mäkikallio, T. (Timo), Biancari, F. (Fausto), Tauriainen, T. (Tuomas), Juvonen, T. (Tatu), Anttila, V. (Vesa), Maaranen, P. (Pasi), Niemelä, M. (Matti), Eskola, M. (Markku), Ahvenvaara, T. (Tuomas), Husso, A. (Annastiina), Virtanen, M. P. (Marko P.O.), Kinnunen, E.-M. (Eeva-Maija), Dahlbacka, S. (Sebastian), Jalava, M. (Maina), Laine, M. (Mika), Valtola, A. (Antti), Raivio, P. (Peter), Vento, A. (Antti), Airaksinen, J. (Juhani), Mäkikallio, T. (Timo), and Biancari, F. (Fausto)

Abstract

Objectives: The authors aimed to investigate the impact of severe bleeding and use of red blood cell (RBC) transfusion on the development of postoperative stroke after surgical (SAVR) and transcatheter aortic valve replacement (TAVR), taken from the FinnValve registry. Design: Nationwide, retrospective observational study. Setting: Five Finnish university hospitals participated in the registry. Participants: A total of 6,463 patients who underwent SAVR (n = 4,333) or TAVR (n = 2,130). Interventions: Patients who underwent TAVR or SAVR with a bioprosthesis with or without coronary revascularization. Measurements and Main Results: The incidence of postoperative stroke after SAVR was 3.8%. In multivariate analysis, the number of transfused RBC units (odds ratio [OR], 1.098; 95% confidence interval [CI], 1.064–1.133) was one of the independent predictors of postoperative stroke. The incidence of stroke increased, along with the severity of perioperative bleeding, according to the European Coronary Artery Bypass Grafting (E-CABG) bleeding grades were as follows: grade 0, 2.2% (reference group); grade 1, 3.4% (adjusted OR, 1.841; 95% CI, 1.105–3.066); grade 2, 5.5% (adjusted OR, 3.282; 95% CI, 1.948–5.529); and grade 3, 14.8% (adjusted OR, 7.103; 95% CI, 3.612–13.966). The incidence of postoperative stroke after TAVR was 2.5%. The number of transfused RBC units was an independent predictor of stroke after TAVR (adjusted OR, 1.155; 95% CI, 1.058–1.261). The incidence of postoperative stroke increased, along with the severity of perioperative bleeding, as stratified by the E-CABG bleeding grades: E-CABG grade 0, 1.7%; grade 1, 5.3% (adjusted OR, 1.270; 95% CI, 0.532–3.035); grade 2, 10.0% (adjusted OR, 2.898; 95% CI, 1.101–7.627); and grade 3, 30.0% (adjusted OR, 10.706; 95% CI, 2.389–47.987). Conclusions: Perioperative bleeding requiring RBC transfusion and/or reoperation for intrathoracic bleeding is associated with an increased risk of postoperative stroke after

Published
2022

4. Transcatheter and surgical aortic valve replacement in patients with left ventricular dysfunction

Author

Jalava, M. P. (Maina P.), Savontaus, M. (Mikko), Ahvenvaara, T. (Tuomas), Laakso, T. (Teemu), Virtanen, M. (Marko), Niemelä, M. (Matti), Tauriainen, T. (Tuomas), Maaranen, P. (Pasi), Husso, A. (Annastiina), Kinnunen, E. (Eve), Dahlbacka, S. (Sebastian), Jaakkola, J. (Jussi), Rosato, S. (Stefano), D’Errigo, P. (Paola), Laine, M. (Mika), Mäkikallio, T. (Timo), Raivio, P. (Peter), Eskola, M. (Markku), Valtola, A. (Antti), Juvonen, T. (Tatu), Biancari, F. (Fausto), Airaksinen, J. (Juhani), Anttila, V. (Vesa), Jalava, M. P. (Maina P.), Savontaus, M. (Mikko), Ahvenvaara, T. (Tuomas), Laakso, T. (Teemu), Virtanen, M. (Marko), Niemelä, M. (Matti), Tauriainen, T. (Tuomas), Maaranen, P. (Pasi), Husso, A. (Annastiina), Kinnunen, E. (Eve), Dahlbacka, S. (Sebastian), Jaakkola, J. (Jussi), Rosato, S. (Stefano), D’Errigo, P. (Paola), Laine, M. (Mika), Mäkikallio, T. (Timo), Raivio, P. (Peter), Eskola, M. (Markku), Valtola, A. (Antti), Juvonen, T. (Tatu), Biancari, F. (Fausto), Airaksinen, J. (Juhani), and Anttila, V. (Vesa)

Abstract

Background: Patients with severe aortic stenosis and left ventricular systolic dysfunction have a poor prognosis, and this may result in inferior survival also after aortic valve replacement. The outcomes of transcatheter and surgical aortic valve replacement were investigated in this comparative analysis. Methods: The retrospective nationwide FinnValve registry included data on patients who underwent transcatheter or surgical aortic valve replacement with a bioprosthesis for severe aortic stenosis. Propensity score matching was performed to adjust the outcomes for baseline covariates of patients with reduced (≤ 50%) left ventricular ejection fraction. Results: Within the unselected, consecutive 6463 patients included in the registry, the prevalence of reduced ejection fraction was 20.8% (876 patients) in the surgical cohort and 27.7% (452 patients) in the transcatheter cohort. Reduced left ventricular ejection fraction was associated with decreased survival (adjusted hazards ratio 1.215, 95%CI 1.067–1.385) after a mean follow-up of 3.6 years. Among 255 propensity score matched pairs, 30-day mortality was 3.1% after transcatheter and 7.8% after surgical intervention (p = 0.038). One-year and 4-year survival were 87.5% and 65.9% after transcatheter intervention and 83.9% and 69.6% after surgical intervention (restricted mean survival time ratio, 1.002, 95%CI 0.929–1.080, p = 0.964), respectively. Conclusions: Reduced left ventricular ejection fraction was associated with increased morbidity and mortality after surgical and transcatheter aortic valve replacement. Thirty-day mortality was higher after surgery, but intermediate-term survival was comparable to transcatheter intervention. Trial registration: The FinnValve registry ClinicalTrials.gov Identifier: NCT03385915.

Published
2022

6. Transcatheter and surgical aortic valve replacement in patients with bicuspid aortic valve

Author

Husso, A. (Annastiina), Airaksinen, J. (Juhani), Juvonen, T. (Tatu), Laine, M. (Mika), Dahlbacka, S. (Sebastian), Virtanen, M. (Marko), Niemelä, M. (Matti), Mäkikallio, T. (Timo), Savontaus, M. (Mikko), Eskola, M. (Markku), Raivio, P. (Peter), Valtola, A. (Antti), Biancari, F. (Fausto), Husso, A. (Annastiina), Airaksinen, J. (Juhani), Juvonen, T. (Tatu), Laine, M. (Mika), Dahlbacka, S. (Sebastian), Virtanen, M. (Marko), Niemelä, M. (Matti), Mäkikallio, T. (Timo), Savontaus, M. (Mikko), Eskola, M. (Markku), Raivio, P. (Peter), Valtola, A. (Antti), and Biancari, F. (Fausto)

Abstract

Objectives: To compare the outcomes after surgical (SAVR) and transcatheter aortic valve replacement (TAVR) for severe stenosis of bicuspid aortic valve (BAV). Methods: We evaluated the early and mid-term outcome of patients with stenotic BAV who underwent SAVR or TAVR for aortic stenosis from the nationwide FinnValve registry. Results: The FinnValve registry included 6463 AS patients and 1023 (15.8%) of them had BAV. SAVR was performed in 920 patients and TAVR in 103 patients with BAV. In the overall series, device success after TAVR was comparable to SAVR (94.2% vs. 97.1%, p = 0.115). TAVR was associated with increased rate of mild-to-severe paravalvular regurgitation (PVR) (19.4% vs. 7.9%, p < 0.0001) and of moderate-to-severe PVR (2.9% vs. 0.7%, p = 0.053). When newer-generation TAVR devices were evaluated, mild-to-severe PVR (11.9% vs. 7.9%, p = 0.223) and moderate-to-severe PVR (0% vs. 0.7%, p = 1.000) were comparable to SAVR. Type 1 N-L and type 2 L-R/R-N were the BAV morphologies with higher incidence of mild-to-severe PVR (37.5% and 100%, adjusted for new-generation prostheses p = 0.025) compared to other types of BAVs. Among 75 propensity score-matched cohorts, 30-day mortality was 1.3% after TAVR and 5.3% after SAVR (p = 0.375), and 2-year mortality was 9.7% after TAVR and 18.7% after SAVR (p = 0.268). Conclusions: In patients with stenotic BAV, TAVR seems to achieve early and mid-term results comparable to SAVR. Type 1 N-L and type 2 L-R/R-N BAV morphologies had higher incidence of PVR. Larger studies evaluating different phenotypes of BAV are needed to confirm these findings. Clinical trial registration: ClinicalTrials.gov Identifier: NCT03385915.

Published
2021

8. Terveydenhuollon kansalliset laaturekisteripilotit loppusuoralla

Author

Keinänen, M. (Mika), Brummer-Korvenkontio, H. (Henrikki), Eskola, M. (Markku), Ettala, O. (Otto), Hartikainen, J. (Juha), Hovi, P. (Petteri), Isosomppi, S. (Sanna), Kivelä, P. (Pia), Kärki, J. (Johanna), Kärkkäinen, J. (Jukka), Laatikainen, T. (Tiina), Liukko, E. (Emmi), Niemi, A. (Anu), Mattila, E. (Elina), Meriläinen, M. (Merja), Mustonen, P. (Pirjo), Pekkanen, L. (Liisa), Puolakka, K. (Kari), Relas, H. (Heikki), Sainio, S. (Salla), Salo, H. (Henri), Salonen, J. (Jonna), Sokka-Isler, T. (Tuulikki), Suvisaari, J. (Jaana), Tahkola, A. (Aapo), Tiirinki, H. (Hanna), Vähäsalo, P. (Paula), Malmivaara, A. (Antti), Keinänen, M. (Mika), Brummer-Korvenkontio, H. (Henrikki), Eskola, M. (Markku), Ettala, O. (Otto), Hartikainen, J. (Juha), Hovi, P. (Petteri), Isosomppi, S. (Sanna), Kivelä, P. (Pia), Kärki, J. (Johanna), Kärkkäinen, J. (Jukka), Laatikainen, T. (Tiina), Liukko, E. (Emmi), Niemi, A. (Anu), Mattila, E. (Elina), Meriläinen, M. (Merja), Mustonen, P. (Pirjo), Pekkanen, L. (Liisa), Puolakka, K. (Kari), Relas, H. (Heikki), Sainio, S. (Salla), Salo, H. (Henri), Salonen, J. (Jonna), Sokka-Isler, T. (Tuulikki), Suvisaari, J. (Jaana), Tahkola, A. (Aapo), Tiirinki, H. (Hanna), Vähäsalo, P. (Paula), and Malmivaara, A. (Antti)

Published
2020

9. Comparison of survival of transfemoral transcatheter aortic valve implantation versus surgical aortic valve replacement for aortic stenosis in low-risk patients without coronary artery disease

Author

Virtanen, M. P. (Marko P.O.), Airaksinen, J. (Juhani), Niemelä, M. (Matti), Laakso, T. (Teemu), Husso, A. (Annastiina), Jalava, M. P. (Maina P.), Tauriainen, T. (Tuomas), Maaranen, P. (Pasi), Kinnunen, E.-M. (Eeva-Maija), Dahlbacka, S. (Sebastian), Rosato, S. (Stefano), Savontaus, M. (Mikko), Juvonen, T. (Tatu), Laine, M. (Mika), Mäkikallio, T. (Timo), Valtola, A. (Antti), Raivio, P. (Peter), Eskola, M. (Markku), Biancari, F. (Fausto), Virtanen, M. P. (Marko P.O.), Airaksinen, J. (Juhani), Niemelä, M. (Matti), Laakso, T. (Teemu), Husso, A. (Annastiina), Jalava, M. P. (Maina P.), Tauriainen, T. (Tuomas), Maaranen, P. (Pasi), Kinnunen, E.-M. (Eeva-Maija), Dahlbacka, S. (Sebastian), Rosato, S. (Stefano), Savontaus, M. (Mikko), Juvonen, T. (Tatu), Laine, M. (Mika), Mäkikallio, T. (Timo), Valtola, A. (Antti), Raivio, P. (Peter), Eskola, M. (Markku), and Biancari, F. (Fausto)

Abstract

Increasing data support transcatheter aortic valve implantation (TAVI) as a valid option over surgical aortic valve replacement (SAVR) in the treatment for severe aortic stenosis (AS) also in patients with low operative risk. However, limited data exist on the outcome of TAVI and SAVR in low-risk patients without coronary artery disease (CAD). The FinnValve registry included data on 6463 patients who underwent TAVI or SAVR with bioprosthesis between 2008 and 2017. Herein, we evaluated the outcome of low operative risk as defined by STS-PROM score <3% and absence of CAD, previous stroke and other relevant co-morbidities. Only patients who underwent TAVI with third-generation prostheses and SAVR with Perimount Magna Ease or Trifecta prostheses were included in this analysis. The primary endpoints were 30-day and 3-year all-cause mortality. Overall, 1,006 patients (175 TAVI patients and 831 SAVR patients) met the inclusion criteria of this analysis. Propensity score matching resulted in 140 pairs with similar baseline characteristics. Among these matched pairs, 30-day mortality was 2.1% in both TAVI and SAVR cohorts (p = 1.00) and 3-year mortality was 17.0% after TAVI and 14.6% after SAVR (p = 0.805). Lower rates of bleeding and atrial fibrillation, and shorter hospital stay were observed after TAVI. The need of new permanent pacemaker implantation and the incidence of early stroke did not differ between groups. In conclusion, TAVI using third-generation prostheses achieved similar early and mid-term survival compared with SAVR in low-risk patients without CAD.

Published
2020

10. Subtype of atrial fibrillation and the outcome of transcatheter aortic valve replacement:the FinnValve study

Author

Jaakkola, J. (Jussi), Jaakkola, S. (Samuli), Airaksinen, K. E. (K. E. Juhani), Husso, A. (Annastiina), Juvonen, T. (Tatu), Laine, M. (Mika), Virtanen, M. (Marko), Maaranen, P. (Pasi), Niemelä, M. (Matti), Mäkikallio, T. (Timo), Savontaus, M. (Mikko), Tauriainen, T. (Tuomas), Valtola, A. (Antti), Vento, A. (Antti), Eskola, M. (Markku), Raivio, P. (Peter), Biancari, F. (Fausto), Jaakkola, J. (Jussi), Jaakkola, S. (Samuli), Airaksinen, K. E. (K. E. Juhani), Husso, A. (Annastiina), Juvonen, T. (Tatu), Laine, M. (Mika), Virtanen, M. (Marko), Maaranen, P. (Pasi), Niemelä, M. (Matti), Mäkikallio, T. (Timo), Savontaus, M. (Mikko), Tauriainen, T. (Tuomas), Valtola, A. (Antti), Vento, A. (Antti), Eskola, M. (Markku), Raivio, P. (Peter), and Biancari, F. (Fausto)

Abstract

Whether the subtype of atrial fibrillation affects outcomes after transcatheter aortic valve replacement for aortic stenosis is unclear. The nationwide FinnValve registry included 2130 patients who underwent primary after transcatheter aortic valve replacement for aortic stenosis during 2008–2017. Altogether, 281 (13.2%) patients had pre-existing paroxysmal atrial fibrillation, 651 (30.6%) had pre-existing non-paroxysmal atrial fibrillation and 160 (7.5%) were diagnosed with new-onset atrial fibrillation during the index hospitalization. The median follow-up was 2.4 (interquartile range: 1.6–3.8) years. Paroxysmal atrial fibrillation did not affect 30-day or overall mortality (p-values >0.05). Non-paroxysmal atrial fibrillation demonstrated an increased risk of overall mortality (hazard ratio: 1.61, 95% confidence interval: 1.35–1.92; p<0.001), but not 30-day mortality (p = 0.084). New-onset atrial fibrillation demonstrated significantly increased 30-day mortality (hazard ratio: 2.76, 95% confidence interval: 1.25–6.09; p = 0.010) and overall mortality (hazard ratio: 1.68, 95% confidence interval: 1.29–2.19; p<0.001). The incidence of early or late stroke did not differ between atrial fibrillation subtypes (p-values >0.05). In conclusion, non-paroxysmal atrial fibrillation and new-onset atrial fibrillation are associated with increased mortality after transcatheter aortic valve replacement for aortic stenosis, whereas paroxysmal atrial fibrillation has no effect on mortality. These findings suggest that non-paroxysmal atrial fibrillation rather than paroxysmal atrial fibrillation may be associated with structural cardiac damage which is of prognostic significance in patients with aortic stenosis undergoing transcatheter aortic valve replacement.

Published
2020

11. Mid-term outcomes of Sapien 3 versus Perimount Magna Ease for treatment of severe aortic stenosis

Author

Virtanen, M. P. (Marko P. O.), Eskola, M. (Markku), Savontaus, M. (Mikko), Juvonen, T. (Tatu), Niemelä, M. (Matti), Laakso, T. (Teemu), Husso, A. (Annastiina), Jalava, M. P. (Maina P.), Tauriainen, T. (Tuomas), Ahvenvaara, T. (Tuomas), Maaranen, P. (Pasi), Kinnunen, E.-M. (Eeva-Maija), Dahlbacka, S. (Sebastian), Laine, M. (Mika), Mäkikallio, T. (Timo), Valtola, A. (Antti), Raivio, P. (Peter), Rosato, S. (Stefano), D’Errigo, P. (Paola), Vento, A. (Antti), Airaksinen, J. (Juhani), Biancari, F. (Fausto), Virtanen, M. P. (Marko P. O.), Eskola, M. (Markku), Savontaus, M. (Mikko), Juvonen, T. (Tatu), Niemelä, M. (Matti), Laakso, T. (Teemu), Husso, A. (Annastiina), Jalava, M. P. (Maina P.), Tauriainen, T. (Tuomas), Ahvenvaara, T. (Tuomas), Maaranen, P. (Pasi), Kinnunen, E.-M. (Eeva-Maija), Dahlbacka, S. (Sebastian), Laine, M. (Mika), Mäkikallio, T. (Timo), Valtola, A. (Antti), Raivio, P. (Peter), Rosato, S. (Stefano), D’Errigo, P. (Paola), Vento, A. (Antti), Airaksinen, J. (Juhani), and Biancari, F. (Fausto)

Abstract

Background: There is limited information on the longer-term outcome after transcatheter aortic valve replacement (TAVR) with new-generation prostheses compared to surgical aortic valve replacement (SAVR). The aim of this study was to compare the mid-term outcomes after TAVR with Sapien 3 and SAVR with Perimount Magna Ease bioprostheses for severe aortic stenosis. Methods: In a retrospective study, we included patients who underwent transfemoral TAVR with Sapien 3 or SAVR with Perimount Magna Ease bioprosthesis between January 2008 and October 2017 from the nationwide FinnValve registry. Propensity score matching was performed to adjust for differences in the baseline characteristics. The Kaplan-Meir method was used to estimate late mortality. Results: A total of 2000 patients were included (689 in the TAVR cohort and 1311 in the SAVR cohort). Propensity score matching resulted in 308 pairs (STS score, TAVR 3.5 ± 2.2% vs. SAVR 3.5 ± 2.8%, p = 0.918). In-hospital mortality was 3.6% after SAVR and 1.3% after TAVR (p = 0.092). Stroke, acute kidney injury, bleeding and atrial fibrillation were significantly more frequent after SAVR, but higher rate of vascular complications was observed after TAVR. The cumulative incidence of permanent pacemaker implantation at 4 years was 13.9% in the TAVR group and 6.9% in the SAVR group (p = 0.0004). At 4-years, all-cause mortality was 20.6% for SAVR and 25.9% for TAVR (p = 0.910). Four-year rates of coronary revascularization, prosthetic valve endocarditis and repeat aortic valve intervention were similar between matched cohorts. Conclusions: The Sapien 3 bioprosthesis achieves comparable midterm outcomes to a surgical bioprosthesis with proven durability such as the Perimount Magna Ease. However, the Sapien 3 bioprosthesis was associated with better early outcome.

Published
2020

13. Assessing the cardiology community position on transradial intervention and the use of bivalirudin in patients with acute coronary syndrome undergoing invasive management: results of an EAPCI survey

Author

Adamo, Marianna, Byrne, Robert A., Baumbach, Andreas, Haude, Michael, Windecker, Stephan, Valgimigli, Marco, Aaroe, J., Abdeltawab, A. A., Accardi, R., Addad, F., Agostoni, P., Alajab, A., Alcázar, E., Alhabil, B., Altug Cakmak, H., Amico, F., Amoroso, G., Anderson, R., Andò, G., Andreou, A. Y., Antoniadis, D., Aquilina, M., Aramberry, L., Auer, J., Auffret, V., Ausiello, A., Austin, D., Avram, A., Ayman, E., Babunashvili, V., Bagur, R., Bakotic, Z., Balducelli, M., Ballesteros, S. M., Baptista, S., Baranauskas, A., Barbeau, G., Bax, M., Benchimol, C., Berroth, R., Biasco, L., Bilal, A., Binias, K., Blanco Mata, R., Boccuzzi, G., Bolognese, L., Boskovic, S., Bourboulis, N., Briguori, C., Bunc, M., Buysschaert, I., Calabro’, P., Campo, G., Candiello, A., Caprotta, U. F., Cardenas, M., Carrilho-Ferreira, P., Carrizo, S., Caruso, M., Cassar, A., Cernigliaro, C., Chacko, G., Chamie, D., Clapp, B., Coceani, M., Colangelo, S., Colombo, A., Comeglio, M., Connaughton, M., Conway, D., Cortese, B., Cosgrave, J., Costa, F., Couvoussis, E., Crimi, G., Crook, R., Cruz-Alvarado, J. E., Curello, S., D’Ascenzo, F., D’Urbano, M., Dana, A., De Backer, O., De Carlo, M., De Cesare, N., De Iaco, G., De La Torre, H. J. M., De Oliveira Netoj, B., Devlin, G. P., Di Lorenzo, E., Díaz, A., Dina, C., Dorsel, T. H., Eberli, F. R., Echeverría, R., Eftychiou, C., Elguindy, A., Ercilla, J., Ernst, A., Esposito, G., Ettori, F., Eufracino, Null, Ezquerra Aguilera, W., Falcone, C., Falu, R. M., Feres, F., Ferlini, M., Fernández, G., Fernández-Rodríguez, D., Fileti, L., Fischetti, D., Florescu, N., Formigli, D., Fouladvand, F., Franco, N., Fresco, C., Frigoli, E., Furmaniuk, J., Gabaldo, K., Galli, M., Galli, S., Garbo, R., Garducci, S., Garg, S., Gavrielatos, G., Gensch, J., Giacchi, G., Giunio, L., Giustino, G., Goldberg, L., Goldsmit, R., Gommeaux, A., González Godínez, H., Gosselin, G., Govorov, A., Grimfjard, P., Gross, E., Grosz, C., Guagliumi, G., Hadad, W., Hadadi, L., Hansen, P. R., Harb, S., Hatrick, R., Hayrapetyan, H. G., Hernández-Enríquez, M., Ho Heo, J., Horvath, I. G., Huan Loh, P., Ibrahim, A. M., Ierna, S., Ilic, I., Imperadore, F., Ionescu-Silva, E., Jacksch, R., James, S., Janiak, B., Jensen, S. E., Jeroen, S., Jugessur, R. K., Kala, P., Kambis, M., Kanakakis, J., Karamasis, G., Karchevsky, D., Karpovskiy, A., Kayaert, P., Kedev, S., Kemala, E., Ketteler, T., Khan, S. Q., Kharlamov, A., Kiernan, T., Kiviniem, T., Koltowski, L., Koskinas, K. C., Kouloumpinis, A., Kraaijeveld, A. O., Krizanic, F., Krötz, B., Kuczmik, W., Kukreja, N., Kuksa, D., Yav, K., Kyriakos, D., Labrunie, A., Laine, M., Lapin, O., Larosa, C., Latib, A., Lattuca, B., Lauer, B., Lefèvre, T., Legrand, V., Lehto, P., Leiva-Pons, J. L., Leone, A. M., Lev, G., Lim, R., Limbruno, U., Linares Vicente, J. A., Lindsay, S., Linnartz, C., Liso, A., Lluberas, R., Locuratolo, N., Lokshyn, S., Lunde, K., Lupi, A., Magnavacchi, P., Maia, F., Mainar, V., Mancone, M., Manolios, M. G., Mansour, S., Mariano, E., Marques, K., Martins, H., Mckenzie, D., Meco, S., Meemook, K., Mehmed, K., Melikyan, A., Mellwig, K. P., Mendiz, O. A., Merkulov, E., Mesquita, H. G., Mezzapelle, G., Miloradovic, V., Mohamed, S., Mohammed, B., Mohammed, F., Mohammed, K., Mohanad, A., Morawiec, B., More, R., Moreno-Martínez, F. L., Mrevlje, B., Muhammad, F., Näveri, H., Nazzaro, M. S., Neary, P., Negus, B. H., Nelson Durval, F. G., Nick, H., Nilva, E., Oldroyd, K. 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B., Quang Hung, D., Rada, I., Rafizadeh, O., Rahman, M. A., Rai, L., Ramsewak, A., Ravindran, R., Rodriguez De Leiras, O. S., Rodriguez Esteban, M., Roque Figueira, H., Saket, A., Sakhov, O., Saktheeswaran, M. K., Salachas, A., Sallam, A., Sampaolesi, A., Samy, A., Sanchis, J., Santaera, O., Santarelli, A., Santharaj, W. S., Sarango, B., Satheesh, S., Schmitz, T., Schuhlen, H., Seewoosagur, R., Segev, A., Seisembekov, V., Semitko, S., Sengottuvelu, G., Sepulveda Varela, P., Sethi, A., Sharma, A., Sharma, R. K., Shi, Hy., Simsek, M. A., Siqueira, B., Skalidis, E., Slawin, J., Sorokhtey, L., Spaulding, C., Srinivas, B., Srinivasan, M., Stakos, D., Stojkovic, S., Tacoy, G., Tawade, M., Tiecco, F., Tondi, S., Torresani, E. M., Tousek, P., Tran, T., Trantalis, G., Triantafyllou, K., Trivedi, R., Trivisonno, A., Tsui, K. L., Turkoglu, C., Tzung-Dau, W., Ueno, H., Urban, U., Uretsky, B. F., Uscumlic, A., Venugopal, V., Verney, R., Vilar, J. V., Villacorta, V. G., Vishwanath, R., Vlachojannis, G. J., Vlachojannis, M., Vlad, V., Von Birgelen, C., Vukcevic, V., Wahab, A., Waksman, R., Wei-Wen, L., Weisz, G., Whittaker, A., Yadav, A., Yokoi, Y., Zacharoulis, A., Zahran, M., Zamani, J., Ziakas, A., Zimmermann, J. P., and Cardiology

Subjects
Hirudin, Percutaneous, Antithrombin, medicine.medical_treatment, Psychological intervention, 030204 cardiovascular system & hematology, medical, 0302 clinical medicine, Peptide Fragment, Surveys and Questionnaires, Surveys and Questionnaire, Medicine, Bivalirudin, 030212 general & internal medicine, Societies, Medical, Transradial, Anticoagulant, Hirudins, Middle Aged, Recombinant Protein, Recombinant Proteins, Femoral Artery, Radial Artery, Cardiology, acute coronary syndrome, bivalirudin, transradial, adult, antithrombins, cardiology, femoral artery, hirudins, humans, middle aged, peptide fragments, percutaneous coronary intervention, recombinant proteins, societies, medical, surveys and questionnaires, attitude of health personnel, radial artery, Acute coronary syndrome, Cardiology and Cardiovascular Medicine, Human, medicine.drug, Adult, medicine.medical_specialty, Attitude of Health Personnel, medicine.drug_class, MEDLINE, Antithrombins, 03 medical and health sciences, societies, Percutaneous Coronary Intervention, Internal medicine, Humans, Acute Coronary Syndrome, Peptide Fragments, Management of acute coronary syndrome, business.industry, Percutaneous coronary intervention, medicine.disease, business
Abstract

AIMS Our aim was to report on a survey initiated by the European Association of Percutaneous Cardiovascular Interventions (EAPCI) collecting the opinion of the cardiology community on the invasive management of acute coronary syndrome (ACS), before and after the MATRIX trial presentation at the American College of Cardiology (ACC) 2015 Scientific Sessions. METHODS AND RESULTS A web-based survey was distributed to all individuals registered on the EuroIntervention mailing list (n=15,200). A total of 572 and 763 physicians responded to the pre- and post-ACC survey, respectively. The radial approach emerged as the preferable access site for ACS patients undergoing invasive management with roughly every other responder interpreting the evidence for mortality benefit as definitive and calling for a guidelines upgrade to class I. The most frequently preferred anticoagulant in ACS patients remains unfractionated heparin (UFH), due to higher costs and greater perceived thrombotic risks associated with bivalirudin. However, more than a quarter of participants declared the use of bivalirudin would increase after MATRIX. CONCLUSIONS The MATRIX trial reinforced the evidence for a causal association between bleeding and mortality and triggered consensus on the superiority of the radial versus femoral approach. The belief that bivalirudin mitigates bleeding risk is common, but UFH still remains the preferred anticoagulant based on lower costs and thrombotic risks.

Published
2016

17. Comparison of outcomes after transcatheter aortic valve replacement vs surgical aortic valve replacement among patients with aortic stenosis at low operative risk

Author

Virtanen, M. P. (Marko P. O.), Eskola, M. (Markku), Jalava, M. P. (Maina P.), Husso, A. (Annastiina), Laakso, T. (Teemu), Niemelä, M. (Matti), Ahvenvaara, T. (Tuomas), Tauriainen, T. (Tuomas), Maaranen, P. (Pasi), Kinnunen, E.-M. (Eeva-Maija), Dahlbacka, S. (Sebastian), Jaakkola, J. (Jussi), Vasankari, T. (Tuija), Airaksinen, J. (Juhani), Anttila, V. (Vesa), Rosato, S. (Stefano), D’Errigo, P. (Paola), Savontaus, M. (Mikko), Juvonen, T. (Tatu), Laine, M. (Mika), Mäkikallio, T. (Timo), Valtola, A. (Antti), Raivio, P. (Peter), Biancari, F. (Fausto), Virtanen, M. P. (Marko P. O.), Eskola, M. (Markku), Jalava, M. P. (Maina P.), Husso, A. (Annastiina), Laakso, T. (Teemu), Niemelä, M. (Matti), Ahvenvaara, T. (Tuomas), Tauriainen, T. (Tuomas), Maaranen, P. (Pasi), Kinnunen, E.-M. (Eeva-Maija), Dahlbacka, S. (Sebastian), Jaakkola, J. (Jussi), Vasankari, T. (Tuija), Airaksinen, J. (Juhani), Anttila, V. (Vesa), Rosato, S. (Stefano), D’Errigo, P. (Paola), Savontaus, M. (Mikko), Juvonen, T. (Tatu), Laine, M. (Mika), Mäkikallio, T. (Timo), Valtola, A. (Antti), Raivio, P. (Peter), and Biancari, F. (Fausto)

Abstract

Importance: Transcatheter aortic valve replacement (TAVR) has been shown to be a valid alternative to surgical aortic valve replacement (SAVR) in patients at high operative risk with severe aortic stenosis (AS). However, the evidence of the benefits and harms of TAVR in patients at low operative risk is still scarce. Objective: To compare the short-term and midterm outcomes after TAVR and SAVR in low-risk patients with AS. Design, Setting, and Participants: This retrospective comparative effectiveness cohort study used data from the Nationwide Finnish Registry of Transcatheter and Surgical Aortic Valve Replacement for Aortic Valve Stenosis of patients at low operative risk who underwent TAVR or SAVR with a bioprosthesis for severe AS from January 1, 2008, to November 30, 2017. Low operative risk was defined as a Society of Thoracic Surgeons Predicted Risk of Mortality score less than 3% without other comorbidities of clinical relevance. One-to-one propensity score matching was performed to adjust for baseline covariates between the TAVR and SAVR cohorts. Exposures: Primary TAVR or SAVR with a bioprosthesis for AS with or without associated coronary revascularization. Main Outcomes and Measures: The primary outcomes were 30-day and 3-year survival. Results: Overall, 2841 patients (mean [SD] age, 74.0 [6.2] years; 1560 [54.9%] men) fulfilled the inclusion criteria and were included in the analysis; TAVR was performed in 325 patients and SAVR in 2516 patients. Propensity score matching produced 304 pairs with similar baseline characteristics. Third-generation devices were used in 263 patients (86.5%) who underwent TAVR. Among these matched pairs, 30-day mortality was 1.3% after TAVR and 3.6% after SAVR (P = .12). Three-year survival was similar in the study cohorts (TAVR, 85.7%; SAVR, 87.7%; P = .45). Interaction tests found no differences in terms of 3-year survival between the study cohorts in patients younger than vs older than 80 years or in patients who r

Published
2019

18. Ten-year experience with transcatheter and surgical aortic valve replacement in Finland

Author

Mäkikallio, T. (Timo), Jalava, M. P. (Maina P.), Husso, A. (Annastiina), Virtanen, M. (Marko), Laakso, T. (Teemu), Ahvenvaara, T. (Tuomas), Tauriainen, T. (Tuomas), Maaranen, P. (Pasi), Kinnunen, E.-M. (Eeva-Maija), Dahlbacka, S. (Sebastian), Jaakkola, J. (Jussi), Airaksinen, J. (Juhani), Anttila, V. (Vesa), Savontaus, M. (Mikko), Laine, M. (Mika), Juvonen, T. (Tatu), Valtola, A. (Antti), Raivio, P. (Peter), Eskola, M. (Markku), Niemelä, M. (Matti), Biancari, F. (Fausto), Mäkikallio, T. (Timo), Jalava, M. P. (Maina P.), Husso, A. (Annastiina), Virtanen, M. (Marko), Laakso, T. (Teemu), Ahvenvaara, T. (Tuomas), Tauriainen, T. (Tuomas), Maaranen, P. (Pasi), Kinnunen, E.-M. (Eeva-Maija), Dahlbacka, S. (Sebastian), Jaakkola, J. (Jussi), Airaksinen, J. (Juhani), Anttila, V. (Vesa), Savontaus, M. (Mikko), Laine, M. (Mika), Juvonen, T. (Tatu), Valtola, A. (Antti), Raivio, P. (Peter), Eskola, M. (Markku), Niemelä, M. (Matti), and Biancari, F. (Fausto)

Abstract

Aim: We investigated the outcomes of transcatheter (TAVR) and surgical aortic valve replacement (SAVR) in Finland during the last decade. Methods: The nationwide FinnValve registry included data from 6463 patients who underwent TAVR or SAVR with a bioprosthesis for aortic stenosis from 2008 to 2017. Results: The annual number of treated patients increased three-fold during the study period. Thirty-day mortality declined from 4.8% to 1.2% for TAVR (p = 0.011) and from 4.1% to 1.8% for SAVR (p = 0.048). Two-year survival improved from 71.4% to 83.9% for TAVR (p < 0.001) and from 87.2% to 91.6% for SAVR (p = 0.006). During the study period, a significant reduction in moderate-to-severe paravalvular regurgitation was observed among TAVR patients and a reduction of the rate of acute kidney injury was observed among both SAVR and TAVR patients. Similarly, the rate of red blood cell transfusion and severe bleeding decreased significantly among SAVR and TAVR patients. Hospital stay declined from 10.4 ± 8.4 to 3.7 ± 3.4 days after TAVR (p < 0.001) and from 9.0 ± 5.9 to 7.8 ± 5.1 days after SAVR (p < 0.001). Conclusions: In Finland, the introduction of TAVR has led to an increase in the invasive treatment of severe aortic stenosis, which was accompanied by improved early outcomes after both SAVR and TAVR.

Published
2019

21. Risks to human and animal health related to the presence of moniliformin in food and feed

Author

EFSA Panel on Contaminants in the Food Chain (CONTAM), Knutsen, HK, Alexander, J, Barregård, L, Bignami, M, Brüschweiler, B, Ceccatelli, S, Cottrill, B, Dinovi, M, Grasl‐Kraupp, B, Hogstrand, C, Hoogenboom, LR, Nebbia, CS, Oswald, IP, Petersen, A, Rose, M, Roudot, AC, Schwerdtle, T, Vleminckx, C, Vollmer, G, Wallace, H, De Saeger, S, Eriksen, GS, Farmer, P, Fremy, J-M, Gong, YY, Meyer, K, Naegeli, H, Parent‐Massin, D, van Egmond, H, Altieri, A, Colombo, P, Eskola, M, van Manen, M, Edler, L, Norwegian Institute of Public Health [Oslo] (NIPH), King‘s College London, Biosynthèse & Toxicité des Mycotoxines (ToxAlim-BioToMyc), ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)

Subjects
Agriculture and Food Sciences, GIBBERELLA-FUJIKUROI, 0301 basic medicine, Novel Foods & Agrochains, IONIZATION MASS-SPECTROMETRY, assessment, Plant Science, medicine.disease_cause, Novel Foods & Agroketens, 01 natural sciences, chemistry.chemical_compound, Occurrence, Medicine and Health Sciences, TX341-641, TURKEY POULTS, BU Toxicology, Novel Foods & Agrochains, Mink, biology, BU Toxicology, 3. Good health, BU Toxicologie, Novel Foods & Agroketens, Human and animal risk assessment, [SDV.TOX]Life Sciences [q-bio]/Toxicology, Toxicity, LIQUID-CHROMATOGRAPHY, Risk assessment, moniliformin, BU Toxicologie, Veterinary (miscellaneous), 030106 microbiology, [SDV.TOX.TVM]Life Sciences [q-bio]/Toxicology/Vegetal toxicology and mycotoxicology, human and animal risk, FUSARIUM MYCOTOXIN MONILIFORMIN, FUMONISIN B-1, TP1-1185, [SDV.TOX.TCA]Life Sciences [q-bio]/Toxicology/Toxicology and food chain, occurrence, Microbiology, Exposure, 03 medical and health sciences, Animal science, SDG 3 - Good Health and Well-being, biology.animal, SELENIUM DEFICIENCY, medicine, Toxicokinetics, Veterinary Sciences, FUJIKUROI CULTURE MATERIAL, human and animal risk assessment, Mycotoxin, VLAG, Cardiotoxicity, [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, Nutrition. Foods and food supply, Chemical technology, 010401 analytical chemistry, MON, toxicity, ASPARAGUS SPEARS, PERFORMANCE, 0104 chemical sciences, Scientific Opinion, chemistry, BROILER CHICKS, Moniliformin, exposure, Animal Science and Zoology, Parasitology, Genotoxicity, Food Science
Abstract

International audience; Moniliformin (MON) is a mycotoxin with low molecular weight primarily produced by Fusarium fungi and occurring predominantly in cereal grains. Following a request of the European Commission, the CONTAM Panel assessed the risk of MON to human and animal health related to its presence in food and feed. The limited information available on toxicity and on toxicokinetics in experimental and farm animals indicated haematotoxicity and cardiotoxicity as major adverse health effects of MON. MON causes chromosome aberrations in vitro but no in vivo genotoxicity data and no carcinogenicity data were identified. Due to the limitations in the available toxicity data, human acute or chronic health-based guidance values (HBGV) could not be established. The margin of exposure (MOE) between the no-observed-adverse-effect level (NOAEL) of 6.0 mg/kg body weight (bw) for cardiotoxicity from a subacute study in rats and the acute upper bound (UB) dietary exposure estimates ranged between 4,000 and 73,000. The MOE between the lowest benchmark dose lower confidence limit (for a 5% response-BMDL 05) of 0.20 mg MON/kg bw per day for haematological hazards from a 28-day study in pigs and the chronic dietary human exposure estimates ranged between 370 and 5,000,000 for chronic dietary exposures. These MOEs indicate a low risk for human health but were associated with high uncertainty. The toxicity data available for poultry, pigs, and mink indicated a low or even negligible risk for these animals from exposure to MON in feed at the estimated exposure levels under current feeding practices. Assuming similar or lower sensitivity as for pigs, the CONTAM Panel considered a low or even negligible risk for the other animal species for which no toxicity data suitable for hazard characterisation were identified. Additional toxicity studies are needed and depending on their outcome, the collection of more occurrence data on MON in food and feed is recommended to enable a comprehensive human risk assessment.

Published
2018

22. 3037The prognostic significance of grade of ischemia in patients with STEMI: a substudy of the randomized trial of primary PCI with or without routine manual thrombectomy (TOTAL trial)

Author

Leivo, J, primary, Anttonen, E, additional, Jolly, S S, additional, Dzavik, V, additional, Koivumaki, J, additional, Tahvanainen, M, additional, Koivula, K, additional, Nikus, K, additional, Wang, J, additional, Cairns, J A, additional, Niemela, K, additional, and Eskola, M, additional

Published
2019
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23. The mycotox charter: Increasing awareness of, and concerted action for, minimizing mycotoxin exposure worldwide

Author

Logrieco, A.F. (Antonio F.), Miller, JD (J. David), Eskola, M. (Mari), Krska, R. (Rudolf), Ayalew, A. (Amare), Bandyopadhyay, R. (Ranajit), Battilani, P. (Paola), Bhatnagar, D. (Deepak), Chulze, S. (Sofia), De Saeger, S. (Sarah), Li, P. (Peiwu), Perrone, G. (Giancarlo), Poapolathep, A. (Amnart), Rahayu, E.S. (Endang S.), Shephard, G.S. (Gordon S.), Stepman, F. (François), Zhang, H. (Hao), Leslie, J.F. (John F.), Logrieco, A.F. (Antonio F.), Miller, JD (J. David), Eskola, M. (Mari), Krska, R. (Rudolf), Ayalew, A. (Amare), Bandyopadhyay, R. (Ranajit), Battilani, P. (Paola), Bhatnagar, D. (Deepak), Chulze, S. (Sofia), De Saeger, S. (Sarah), Li, P. (Peiwu), Perrone, G. (Giancarlo), Poapolathep, A. (Amnart), Rahayu, E.S. (Endang S.), Shephard, G.S. (Gordon S.), Stepman, F. (François), Zhang, H. (Hao), and Leslie, J.F. (John F.)

Abstract

Mycotoxins are major food contaminants affecting global food security, especially in low and middle-income countries. The European Union (EU) funded project, MycoKey, focuses on “Integrated and innovative key actions for mycotoxin management in the food and feed chains” and the right to safe food through mycotoxin management strategies and regulation, which are fundamental to minimizing the unequal access to safe and sufficient food worldwide. As part of the MycoKey project, a Mycotoxin Charter (charter.mycokey.eu) was launched to share the need for global harmonization of mycotoxin legislation and policies and to minimize human and animal exposure worldwide, with particular attention to less developed countries that lack effective legislation. This document is in response to a demand that has built through previous European Framework Projects—MycoGlobe and MycoRed—in the previous decade to control and reduce mycotoxin contamination worldwide. All suppliers, participants and beneficiaries of the food supply chain, for example, farmers, consumers, stakeholders, researchers, members of civil society and government and so forth, are invited to sign this charter and to support this initiative.

Published
2018
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24. Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes

Author

Pulit, SL, Weng, L-C, McArdle, PF, Trinquart, L, Choi, SH, Mitchell, BD, Rosand, J, de Bakker, PIW, Benjamin, EJ, Ellinor, PT, Kittner, SJ, Lubitz, SA, Anderson, CD, Christophersen, IE, Rienstra, M, Roselli, C, Yin, X, Geelhoed, B, Barnard, J, Lin, H, Arking, DE, Smith, A, Albert, CM, Chaffin, M, Tucker, NR, Li, M, Klarin, D, Bihlmeyer, NA, Low, S-K, Weeke, PE, Mueller-Nurasyid, M, Smith, JG, Brody, JA, Niemeijer, MN, Doerr, M, Trompet, S, Huffman, J, Gustafsson, S, Schurmann, C, Kleber, ME, Lyytikainen, L-P, Seppala, I, Malik, R, Horimoto, ARVR, Perez, M, Sinisalo, J, Aeschbacher, S, Theriault, S, Yao, J, Radmanesh, F, Weiss, S, Teumer, A, Clauss, S, Deo, R, Rader, DJ, Shah, S, Sun, A, Hopewell, JC, Debette, S, Chauhan, G, Yang, Q, Worrall, BB, Pare, G, Kamatani, Y, Hagemeijer, YP, Verweij, N, Siland, JE, Kubo, M, Smith, JD, Van Wagoner, DR, Bis, JC, Perz, S, Psaty, BM, Ridker, PM, Magnani, JW, Harris, TB, Launer, LJ, Shoemaker, MB, Padmanabhan, S, Haessler, J, Bartz, TM, Waldenberger, M, Lichtner, P, Arendt, M, Krieger, JE, Kahonen, M, Risch, L, Mansur, AJ, Peters, A, Smith, BH, Lind, L, Scott, SA, Lu, Y, Bottinger, EB, Hernesniemi, J, Lindgren, CM, Wong, JA, Huang, J, Eskola, M, Morris, AP, Ford, I, Reiner, AP, Delgado, G, Chen, LY, Chen, Y-DI, Sandhu, RK, Boerwinkle, E, Eisele, L, Lannfelt, L, Rost, N, Taylor, KD, Campbell, A, Magnusson, PK, Porteous, D, Hocking, LJ, Vlachopoulou, E, Pedersen, NL, Nikus, K, Orho-Melander, M, Hamsten, A, Heeringa, J, Denny, JC, Kriebel, J, Darbar, D, Newton-Cheh, C, Shaffer, C, Macfarlane, PW, Heilmann, S, Almgren, P, Huang, PL, Sotoodehnia, N, Soliman, EZ, Uitterlinden, AG, Hofman, A, Franco, OH, Voelker, U, Joeckel, K-H, Sinner, MF, Lin, HJ, Guo, X, Dichgans, M, Ingelsson, E, Kooperberg, C, Melander, O, Loos, RJF, Laurikka, J, Conen, D, van der Harst, P, Lokki, M-L, Kathiresan, S, Pereira, A, Jukema, JW, Hayward, C, Rotter, J, Maerz, W, Lehtimaki, T, Stricker, BH, Chung, MK, Felix, SB, Gudnason, V, Alonso, A, Roden, DM, Kaeaeb, S, Chasman, D, Heckbert, SR, Tanaka, T, Lunetta, KL, Smoller, S, Sorkin, J, Wang, X, Selim, M, Pikula, A, Wolf, P, Seshadri, S, de Bakker, P, Rexrode, K, Chen, I, Luke, M, Sale, M, Lee, T-H, Chang, K-C, Elkind, M, Goldstein, L, James, ML, Breteler, M, O'Donnell, C, Leys, D, Carty, C, Kidwell, C, Olesen, J, Sharma, P, Rich, S, Tatlisumak, T, Happola, O, Bijlenga, P, Soriano, C, Giralt, E, Roquer, J, Jimenez-Conde, J, Cotlarcius, I, Hardy, J, Korostynski, M, Boncoraglio, G, Ballabio, E, Parati, E, Mateusz, A, Urbanik, A, Dziedzic, T, Jagiella, J, Gasowski, J, Wnuk, M, Olszanecki, R, Pera, J, Slowik, A, Juchniewicz, KJ, Levi, C, Nyquist, P, Cendes, I, Cabral, N, Franca, P, Goncalves, A, Keller, L, Crisby, M, Kostulas, K, Lemmens, R, Ahmadi, K, Opherk, C, Duering, M, Gonik, M, Staals, J, Burri, P, Sadr-Nabavi, A, Romero, J, Biffi, A, Anderson, C, Falcone, G, Brouwers, B, Du, R, Kourkoulis, C, Battey, T, Lubitz, S, Mueller-Myhsok, B, Meschia, J, Brott, T, Pichler, A, Enzinger, C, Schmidt, H, Schmidt, R, Seiler, S, Blanton, S, Yamada, Y, Bersano, A, Rundek, T, Sacco, R, Chan, Y-FY, Gschwendtner, A, Deng, Z, Barr, T, Gwinn, K, Corriveau, R, Singleton, A, Waddy, S, Launer, L, Chen, C, Le, KE, Lee, WL, Tan, EK, Olugbodi, A, Rothwell, P, Schilling, S, Mok, V, Lebedeva, E, Jern, C, Jood, K, Olsson, S, Kim, H, Lee, C, Kilarski, L, Markus, H, Peycke, J, Bevan, S, Sheu, W, Chiou, HY, Chern, J, Giraldo, E, Taqi, M, Jain, V, Lam, O, Howard, G, Woo, D, Kittner, S, Mitchell, B, Cole, J, O'Connell, J, Milewicz, D, Illoh, K, Worrall, B, Stine, C, Karaszewski, B, Werring, D, Sofat, R, Smalley, J, Lindgren, A, Hansen, B, Norrving, B, Smith, G, Jose Martin, J, Thijs, V, Klijn, K, van't Hof, F, Algra, A, Macleod, M, Perry, R, Arnett, D, Pezzini, A, Padovani, A, Cramer, S, Fisher, M, Saleheen, D, Broderick, J, Kissela, B, Doney, A, Sudlow, C, Rannikmae, K, Silliman, S, McDonough, C, Walters, M, Pedersen, A, Nakagawa, K, Chang, C, Dobbins, M, McArdle, P, Chang, Y-C, Brown, R, Brown, D, Holliday, E, Kalaria, R, Maguire, J, Attia, J, Farrall, M, Giese, A-K, Fornage, M, Majersik, J, Cushman, M, Keene, K, Bennett, S, Tirschwell, D, Psaty, B, Reiner, A, Longstreth, W, Spence, D, Montaner, J, Fernandez-Cadenas, I, Langefeld, C, Bushnell, C, Heitsch, L, Lee, J-M, Sheth, K, Pulit, SL, Weng, L-C, McArdle, PF, Trinquart, L, Choi, SH, Mitchell, BD, Rosand, J, de Bakker, PIW, Benjamin, EJ, Ellinor, PT, Kittner, SJ, Lubitz, SA, Anderson, CD, Christophersen, IE, Rienstra, M, Roselli, C, Yin, X, Geelhoed, B, Barnard, J, Lin, H, Arking, DE, Smith, A, Albert, CM, Chaffin, M, Tucker, NR, Li, M, Klarin, D, Bihlmeyer, NA, Low, S-K, Weeke, PE, Mueller-Nurasyid, M, Smith, JG, Brody, JA, Niemeijer, MN, Doerr, M, Trompet, S, Huffman, J, Gustafsson, S, Schurmann, C, Kleber, ME, Lyytikainen, L-P, Seppala, I, Malik, R, Horimoto, ARVR, Perez, M, Sinisalo, J, Aeschbacher, S, Theriault, S, Yao, J, Radmanesh, F, Weiss, S, Teumer, A, Clauss, S, Deo, R, Rader, DJ, Shah, S, Sun, A, Hopewell, JC, Debette, S, Chauhan, G, Yang, Q, Worrall, BB, Pare, G, Kamatani, Y, Hagemeijer, YP, Verweij, N, Siland, JE, Kubo, M, Smith, JD, Van Wagoner, DR, Bis, JC, Perz, S, Psaty, BM, Ridker, PM, Magnani, JW, Harris, TB, Launer, LJ, Shoemaker, MB, Padmanabhan, S, Haessler, J, Bartz, TM, Waldenberger, M, Lichtner, P, Arendt, M, Krieger, JE, Kahonen, M, Risch, L, Mansur, AJ, Peters, A, Smith, BH, Lind, L, Scott, SA, Lu, Y, Bottinger, EB, Hernesniemi, J, Lindgren, CM, Wong, JA, Huang, J, Eskola, M, Morris, AP, Ford, I, Reiner, AP, Delgado, G, Chen, LY, Chen, Y-DI, Sandhu, RK, Boerwinkle, E, Eisele, L, Lannfelt, L, Rost, N, Taylor, KD, Campbell, A, Magnusson, PK, Porteous, D, Hocking, LJ, Vlachopoulou, E, Pedersen, NL, Nikus, K, Orho-Melander, M, Hamsten, A, Heeringa, J, Denny, JC, Kriebel, J, Darbar, D, Newton-Cheh, C, Shaffer, C, Macfarlane, PW, Heilmann, S, Almgren, P, Huang, PL, Sotoodehnia, N, Soliman, EZ, Uitterlinden, AG, Hofman, A, Franco, OH, Voelker, U, Joeckel, K-H, Sinner, MF, Lin, HJ, Guo, X, Dichgans, M, Ingelsson, E, Kooperberg, C, Melander, O, Loos, RJF, Laurikka, J, Conen, D, van der Harst, P, Lokki, M-L, Kathiresan, S, Pereira, A, Jukema, JW, Hayward, C, Rotter, J, Maerz, W, Lehtimaki, T, Stricker, BH, Chung, MK, Felix, SB, Gudnason, V, Alonso, A, Roden, DM, Kaeaeb, S, Chasman, D, Heckbert, SR, Tanaka, T, Lunetta, KL, Smoller, S, Sorkin, J, Wang, X, Selim, M, Pikula, A, Wolf, P, Seshadri, S, de Bakker, P, Rexrode, K, Chen, I, Luke, M, Sale, M, Lee, T-H, Chang, K-C, Elkind, M, Goldstein, L, James, ML, Breteler, M, O'Donnell, C, Leys, D, Carty, C, Kidwell, C, Olesen, J, Sharma, P, Rich, S, Tatlisumak, T, Happola, O, Bijlenga, P, Soriano, C, Giralt, E, Roquer, J, Jimenez-Conde, J, Cotlarcius, I, Hardy, J, Korostynski, M, Boncoraglio, G, Ballabio, E, Parati, E, Mateusz, A, Urbanik, A, Dziedzic, T, Jagiella, J, Gasowski, J, Wnuk, M, Olszanecki, R, Pera, J, Slowik, A, Juchniewicz, KJ, Levi, C, Nyquist, P, Cendes, I, Cabral, N, Franca, P, Goncalves, A, Keller, L, Crisby, M, Kostulas, K, Lemmens, R, Ahmadi, K, Opherk, C, Duering, M, Gonik, M, Staals, J, Burri, P, Sadr-Nabavi, A, Romero, J, Biffi, A, Anderson, C, Falcone, G, Brouwers, B, Du, R, Kourkoulis, C, Battey, T, Lubitz, S, Mueller-Myhsok, B, Meschia, J, Brott, T, Pichler, A, Enzinger, C, Schmidt, H, Schmidt, R, Seiler, S, Blanton, S, Yamada, Y, Bersano, A, Rundek, T, Sacco, R, Chan, Y-FY, Gschwendtner, A, Deng, Z, Barr, T, Gwinn, K, Corriveau, R, Singleton, A, Waddy, S, Launer, L, Chen, C, Le, KE, Lee, WL, Tan, EK, Olugbodi, A, Rothwell, P, Schilling, S, Mok, V, Lebedeva, E, Jern, C, Jood, K, Olsson, S, Kim, H, Lee, C, Kilarski, L, Markus, H, Peycke, J, Bevan, S, Sheu, W, Chiou, HY, Chern, J, Giraldo, E, Taqi, M, Jain, V, Lam, O, Howard, G, Woo, D, Kittner, S, Mitchell, B, Cole, J, O'Connell, J, Milewicz, D, Illoh, K, Worrall, B, Stine, C, Karaszewski, B, Werring, D, Sofat, R, Smalley, J, Lindgren, A, Hansen, B, Norrving, B, Smith, G, Jose Martin, J, Thijs, V, Klijn, K, van't Hof, F, Algra, A, Macleod, M, Perry, R, Arnett, D, Pezzini, A, Padovani, A, Cramer, S, Fisher, M, Saleheen, D, Broderick, J, Kissela, B, Doney, A, Sudlow, C, Rannikmae, K, Silliman, S, McDonough, C, Walters, M, Pedersen, A, Nakagawa, K, Chang, C, Dobbins, M, McArdle, P, Chang, Y-C, Brown, R, Brown, D, Holliday, E, Kalaria, R, Maguire, J, Attia, J, Farrall, M, Giese, A-K, Fornage, M, Majersik, J, Cushman, M, Keene, K, Bennett, S, Tirschwell, D, Psaty, B, Reiner, A, Longstreth, W, Spence, D, Montaner, J, Fernandez-Cadenas, I, Langefeld, C, Bushnell, C, Heitsch, L, Lee, J-M, and Sheth, K

Abstract

OBJECTIVE: We sought to assess whether genetic risk factors for atrial fibrillation (AF) can explain cardioembolic stroke risk. METHODS: We evaluated genetic correlations between a previous genetic study of AF and AF in the presence of cardioembolic stroke using genome-wide genotypes from the Stroke Genetics Network (N = 3,190 AF cases, 3,000 cardioembolic stroke cases, and 28,026 referents). We tested whether a previously validated AF polygenic risk score (PRS) associated with cardioembolic and other stroke subtypes after accounting for AF clinical risk factors. RESULTS: We observed a strong correlation between previously reported genetic risk for AF, AF in the presence of stroke, and cardioembolic stroke (Pearson r = 0.77 and 0.76, respectively, across SNPs with p < 4.4 × 10-4 in the previous AF meta-analysis). An AF PRS, adjusted for clinical AF risk factors, was associated with cardioembolic stroke (odds ratio [OR] per SD = 1.40, p = 1.45 × 10-48), explaining ∼20% of the heritable component of cardioembolic stroke risk. The AF PRS was also associated with stroke of undetermined cause (OR per SD = 1.07, p = 0.004), but no other primary stroke subtypes (all p > 0.1). CONCLUSIONS: Genetic risk of AF is associated with cardioembolic stroke, independent of clinical risk factors. Studies are warranted to determine whether AF genetic risk can serve as a biomarker for strokes caused by AF.

Published
2018

25. Risks to human and animal health related to the presence of deoxynivalenol and its acetylated and modified forms in food and feed

Author

EFSA Panel on Contaminants in the Food Chain (CONTAM), Knutsen, HK, Alexander, J, Barregård, L, Bignami, M, Brüschweiler, B, Ceccatelli, S, Cottrill, B, Dinovi, M, Grasl‐Kraupp, B, Hogstrand, C, Hoogenboom, LR, Nebbia, CS, Oswald, IP, Petersen, A, Rose, M, Roudot, A-C, Schwerdtle, T, Vleminckx, C, Vollmer, G, Wallace, H, De Saeger, S, Eriksen, GS, Farmer, P, Fremy, J-M, Gong, YY, Meyer, K, Naegeli, H, Parent‐Massin, D, Rietjens, I, van Egmond, H, Altieri, A, Eskola, M, Gergelova, P, Ramos Bordajandi, L, Benkova, B, Dörr, B, Gkrillas, A, Gustavsson, N, van Manen, M, and Edler, L

Subjects
food and beverages
Abstract

Deoxynivalenol (DON) is a mycotoxin primarily produced by Fusarium fungi, occurring predominantly in cereal grains. Following the request of the European Commission, the CONTAM Panel assessed the risk to animal and human health related to DON, 3-acetyl-DON (3-Ac-DON), 15-acetyl-DON (15-Ac-DON) and DON-3-glucoside in food and feed. A total of 27,537, 13,892, 7,270 and 2,266 analytical data for DON, 3-Ac-DON, 15-Ac-DON and DON-3-glucoside, respectively, in food, feed and unprocessed grains collected from 2007 to 2014 were used. For human exposure, grains and grain-based products were main sources, whereas in farm and companion animals, cereal grains, cereal by-products and forage maize contributed most. DON is rapidly absorbed, distributed, and excreted. Since 3-Ac-DON and 15-Ac-DON are largely deacetylated and DON-3-glucoside cleaved in the intestines the same toxic effects as DON can be expected. The TDI of 1 μg/kg bw per day, that was established for DON based on reduced body weight gain in mice, was therefore used as a group-TDI for the sum of DON, 3-Ac-DON, 15-Ac-DON and DON-3-glucoside. In order to assess acute human health risk, epidemiological data from mycotoxicoses were assessed and a group-ARfD of 8 μg/kg bw per eating occasion was calculated. Estimates of acute dietary exposures were below this dose and did not raise a health concern in humans. The estimated mean chronic dietary exposure was above the group-TDI in infants, toddlers and other children, and at high exposure also in adolescents and adults, indicating a potential health concern. Based on estimated mean dietary concentrations in ruminants, poultry, rabbits, dogs and cats, most farmed fish species and horses, adverse effects are not expected. At the high dietary concentrations, there is a potential risk for chronic adverse effects in pigs and fish and for acute adverse effects in cats and farmed mink.

Published
2017

26. Genetic loci associated with heart rate variability and their effects on cardiac disease risk

Author

Nolte, IM, Munoz, ML, Tragante, V, Amare, AT, Jansen, R, Vaez, A, Von Der Heyde, B, Avery, CL, Bis, JC, Dierckx, B, Van Dongen, J, Gogarten, SM, Goyette, P, Hernesniemi, J, Huikari, V, Hwang, SJ, Jaju, D, Kerr, KF, Kluttig, A, Krijthe, BP, Kumar, J, Van Der Laan, SW, Lyytikäinen, LP, Maihofer, AX, Minassian, A, Van Der Most, PJ, Müller-Nurasyid, M, Nivard, M, Salvi, E, Stewart, JD, Thayer, JF, Verweij, N, Wong, A, Zabaneh, D, Zafarmand, MH, Abdellaoui, A, Albarwani, S, Albert, C, Alonso, A, Ashar, F, Auvinen, J, Axelsson, T, Baker, DG, De Bakker, PIW, Barcella, M, Bayoumi, R, Bieringa, RJ, Boomsma, D, Boucher, G, Britton, AR, Christophersen, IE, Dietrich, A, Ehret, GB, Ellinor, PT, Eskola, M, Felix, JF, Floras, JS, Franco, OH, Friberg, P, Gademan, MGJ, Geyer, MA, Giedraitis, V, Hartman, CA, Hemerich, D, Hofman, A, Hottenga, JJ, Huikuri, H, Hutri-Kähönen, N, and Jouven, X

Abstract

Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide association studies for three HRV traits in up to 53,174 individuals of European ancestry, we detect 17 genome-wide significant SNPs in eight loci. HRV SNPs tag non-synonymous SNPs (in NDUFA11 and KIAA1755), expression quantitative trait loci (eQTLs) (influencing GNG11, RGS6 and NEO1), or are located in genes preferentially expressed in the sinoatrial node (GNG11, RGS6 and HCN4). Genetic risk scores account for 0.9 to 2.6% of the HRV variance. Significant genetic correlation is found for HRV with heart rate (-0.74

Published
2017

27. Multi-strains Bacillus DFM-mediated competition and exclusion in attachment of pathogens to broiler intestinal mucus in vitro

Author

Bernardeau, Marion, Eskola, M, Nurminen, P., Danisco Animal Nutrition, Aliments Bioprocédés Toxicologie Environnements (ABTE), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), DuPont Health & Nutrition, and Bernardeau, Marion

Subjects
[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, [SDV.BA.MVSA] Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2016

28. P1494The prognostic significance of atrial fibrillation in patients with ST-elevation myocardial infarction: a sub-study of the randomized TOTAL trial

Author

Anttonen, E M J, primary, Leivo, J, additional, Jolly, S S, additional, Dzavik, V, additional, Koivumaeki, J K, additional, Tahvanainen, M, additional, Koivula, K, additional, Nikus, K, additional, Wang, J, additional, Cairns, J A, additional, Niemelae, K, additional, and Eskola, M, additional

Published
2018
Full Text
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29. P3680The high-risk ECG pattern of ST-elevation myocardial infarction: a substudy of the randomized trial of primary PCI with or without routine manual thrombectomy (TOTAL trial)

Author

Leivo, J, primary, Anttonen, E, additional, Jolly, S S, additional, Dzavik, V, additional, Koivumaki, J, additional, Tahvanainen, M, additional, Koivula, K, additional, Nikus, K, additional, Wang, J, additional, Cairns, J A, additional, Niemela, K, additional, and Eskola, M J, additional

Published
2018
Full Text
View/download PDF

32. Permanent work disability in patients ≤50 years old after percutaneous coronary intervention and coronary artery bypass grafting (the CRAGS study)

Author

Lautamäki, A. (Anna), Gunn, J. M. (Jarmo M.), Airaksinen, K. E. (Kari Eino Juhani), Biancari, F. (Fausto), Kajander, O. A. (Olli A.), Anttila, V. (Vesa), Heikkinen, J. (Jouni), Eskola, M. (Markku), Ilveskoski, E. (Erkki), Mennander, A. (Ari), Korpilahti, K. (Kari), Wistbacka, J.-O. (Jan-Ola), Kiviniemi, T. O. (Tuomas O.), Lautamäki, A. (Anna), Gunn, J. M. (Jarmo M.), Airaksinen, K. E. (Kari Eino Juhani), Biancari, F. (Fausto), Kajander, O. A. (Olli A.), Anttila, V. (Vesa), Heikkinen, J. (Jouni), Eskola, M. (Markku), Ilveskoski, E. (Erkki), Mennander, A. (Ari), Korpilahti, K. (Kari), Wistbacka, J.-O. (Jan-Ola), and Kiviniemi, T. O. (Tuomas O.)

Abstract

Background: The aim of this study was to investigate the incidence of permanent working disability (PWD) in young patients after percutaneous or surgical coronary revascularization. Methods and Results: The study included 1035 consecutive patients ≤50 years old who underwent coronary revascularization [910 and 125 patients in percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) groups, respectively] between 2002 and 2012 at 4 Finnish hospitals. The median follow-up time was 41 months. The overall incidence of PWD was higher after CABG compared to PCI (at 5 years, 34.8 vs. 14.7%, P < 0.001). Freedom from PWD in the general population aged 45 was 97.2% at 4 years follow-up. Median time to grant disability pension was 11.6 months after CABG and 24.4 months after PCI (P = 0.018). Reasons for PWD were classified as cardiac (35.3 vs. 36.9%), psychiatric (14.7 vs. 14.6%), and musculoskeletal (14.7 vs. 15.5%) in patients undergoing CABG vs. PCI. Overall freedom from PWD was higher in patients without major adverse cardiac and cerebrovascular event (MACCE) (at 5 years, 85.6 vs. 71.9%, P < 0.001). Nevertheless, rate of PWD was high also in patients without MACCE and patients with preserved ejection fraction during follow-up. Conclusions: Although coronary revascularization confers good overall survival in young patients, PWD is common especially after CABG and mostly for cardiac reasons even without occurrence of MACCE. Supportive measures to preserve occupational health are warranted concomitantly with coronary revascularization at all levels of health care.

Published
2017

33. Genetic loci associated with heart rate variability and their effects on cardiac disease risk

Author

Nolte, I. M. (Ilja M.), Munoz, M. L. (M. Loretto), Tragante, V. (Vinicius), Amare, A. T. (Azmeraw T.), Jansen, R. (Rick), Vaez, A. (Ahmad), von der Heyde, B. (Benedikt), Avery, C. L. (Christy L.), Bis, J. C. (Joshua C.), Dierckx, B. (Bram), van Dongen, J. (Jenny), Gogarten, S. M. (Stephanie M.), Goyette, P. (Philippe), Hernesniemi, J. (Jussi), Huikari, V. (Ville), Hwang, S.-J. (Shih-Jen), Jaju, D. (Deepali), Kerr, K. F. (Kathleen F.), Kluttig, A. (Alexander), Krijthe, B. P. (Bouwe P.), Kumar, J. (Jitender), van der Laan, S. W. (Sander W.), Lyytikäinen, L.-P. (Leo-Pekka), Maihofer, A. X. (Adam X.), Minassian, A. (Arpi), van der Most, P. J. (Peter J.), Mueller-Nurasyid, M. (Martina), Nivard, M. (Michel), Salvi, E. (Erika), Stewart, J. D. (James D.), Thayer, J. F. (Julian F.), Verweij, N. (Niek), Wong, A. (Andrew), Zabaneh, D. (Delilah), Zafarmand, M. H. (Mohammad H.), Abdellaoui, A. (Abdel), Albarwani, S. (Sulayma), Albert, C. (Christine), Alonso, A. (Alvaro), Ashar, F. (Foram), Auvinen, J. (Juha), Axelsson, T. (Tomas), Baker, D. G. (Dewleen G.), de Bakker, P. I. (Paul I. W.), Barcella, M. (Matteo), Bayoumi, R. (Riad), Bieringa, R. J. (Rob J.), Boomsma, D. (Dorret), Boucher, G. (Gabrielle), Britton, A. R. (Annie R.), Christophersen, I. E. (Ingrid E.), Dietrich, A. (Andrea), Ehret, G. B. (George B.), Ellinor, P. T. (Patrick T.), Eskola, M. (Markku), Felix, J. F. (Janine F.), Floras, J. S. (John S.), Franco, O. H. (Oscar H.), Friberg, P. (Peter), Gademan, M. G. (Maaike G. J.), Geyer, M. A. (Mark A.), Giedraitis, V. (Vilmantas), Hartman, C. A. (Catharina A.), Hemerich, D. (Daiane), Hofman, A. (Albert), Hottenga, J.-J. (Jouke-Jan), Huikuri, H. (Heikki), Hutri-Kähönen, N. (Nina), Jouven, X. (Xavier), Junttila, J. (Juhani), Juonala, M. (Markus), Kiviniemi, A. M. (Antti M.), Kors, J. A. (Jan A.), Kumari, M. (Meena), Kuznetsova, T. (Tatiana), Laurie, C. C. (Cathy C.), Lefrandt, J. D. (Joop D.), Li, Y. (Yong), Li, Y. (Yun), Liao, D. (Duanping), Limacher, M. C. (Marian C.), Lin, H. J. (Henry J.), Lindgren, C. M. (Cecilia M.), Lubitz, S. A. (Steven A.), Mahajan, A. (Anubha), McKnight, B. (Barbara), zu Schwabedissen, H. M. (Henriette Meyer), Milaneschi, Y. (Yuri), Mononen, N. (Nina), Morris, A. P. (Andrew P.), Nalls, M. A. (Mike A.), Navis, G. (Gerjan), Neijts, M. (Melanie), Nikus, K. (Kjell), North, K. E. (Kari E.), O'Connor, D. T. (Daniel T.), Ormel, J. (Johan), Perz, S. (Siegfried), Peters, A. (Annette), Psaty, B. M. (Bruce M.), Raitakari, O. T. (Olli T.), Risbrough, V. B. (Victoria B.), Sinner, M. F. (Moritz F.), Siscovick, D. (David), Smit, J. H. (Johannes H.), Smith, N. L. (Nicholas L.), Soliman, E. Z. (Elsayed Z.), Sotoodehnia, N. (Nona), Staessen, J. A. (Jan A.), Stein, P. K. (Phyllis K.), Stilp, A. M. (Adrienne M.), Stolarz-Skrzypek, K. (Katarzyna), Strauch, K. (Konstantin), Sundström, J. (Johan), Swenne, C. A. (Cees A.), Syvänen, A.-C. (Ann-Christine), Tardif, J.-C. (Jean-Claude), Taylor, K. D. (Kent D.), Teumer, A. (Alexander), Thornton, T. A. (Timothy A.), Tinker, L. E. (Lesley E.), Uitterlinden, A. G. (Andre G.), van Setten, J. (Jessica), Voss, A. (Andreas), Waldenberger, M. (Melanie), Wilhelmsen, K. C. (Kirk C.), Willemsen, G. (Gonneke), Wong, Q. (Quenna), Zhang, Z.-M. (Zhu-Ming), Zonderman, A. B. (Alan B.), Cusi, D. (Daniele), Evans, M. K. (Michele K.), Greiser, H. K. (Halina K.), van der Harst, P. (Pim), Hassan, M. (Mohammad), Ingelsson, E. (Erik), Järvelin, M.-R. (Marjo-Riitta), Kaab, S. (Stefan), Kähönen, M. (Mika), Kivimäki, M. (Mika), Kooperberg, C. (Charles), Kuh, D. (Diana), Lehtimäki, T. (Terho), Lind, L. (Lars), Nievergelt, C. M. (Caroline M.), O'Donnell, C. J. (Chris J.), Oldehinkel, A. J. (Albertine J.), Penninx, B. (Brenda), Reiner, A. P. (Alexander P.), Riese, H. (Harriette), van Roon, A. M. (Arie M.), Rioux, J. D. (John D.), Rotter, J. I. (Jerome I.), Sofer, T. (Tamar), Stricker, B. H. (Bruno H.), Tiemeier, H. (Henning), Vrijkotte, T. G. (Tanja G. M.), Asselbergs, F. W. (Folkert W.), Brundel, B. J. (Bianca J. J. M.), Heckbert, S. R. (Susan R.), Whitsel, E. A. (Eric A.), den Hoed, M. (Marcel), Snieder, H. (Harold), de Geus, E. J. (Eco J. C.), Nolte, I. M. (Ilja M.), Munoz, M. L. (M. Loretto), Tragante, V. (Vinicius), Amare, A. T. (Azmeraw T.), Jansen, R. (Rick), Vaez, A. (Ahmad), von der Heyde, B. (Benedikt), Avery, C. L. (Christy L.), Bis, J. C. (Joshua C.), Dierckx, B. (Bram), van Dongen, J. (Jenny), Gogarten, S. M. (Stephanie M.), Goyette, P. (Philippe), Hernesniemi, J. (Jussi), Huikari, V. (Ville), Hwang, S.-J. (Shih-Jen), Jaju, D. (Deepali), Kerr, K. F. (Kathleen F.), Kluttig, A. (Alexander), Krijthe, B. P. (Bouwe P.), Kumar, J. (Jitender), van der Laan, S. W. (Sander W.), Lyytikäinen, L.-P. (Leo-Pekka), Maihofer, A. X. (Adam X.), Minassian, A. (Arpi), van der Most, P. J. (Peter J.), Mueller-Nurasyid, M. (Martina), Nivard, M. (Michel), Salvi, E. (Erika), Stewart, J. D. (James D.), Thayer, J. F. (Julian F.), Verweij, N. (Niek), Wong, A. (Andrew), Zabaneh, D. (Delilah), Zafarmand, M. H. (Mohammad H.), Abdellaoui, A. (Abdel), Albarwani, S. (Sulayma), Albert, C. (Christine), Alonso, A. (Alvaro), Ashar, F. (Foram), Auvinen, J. (Juha), Axelsson, T. (Tomas), Baker, D. G. (Dewleen G.), de Bakker, P. I. (Paul I. W.), Barcella, M. (Matteo), Bayoumi, R. (Riad), Bieringa, R. J. (Rob J.), Boomsma, D. (Dorret), Boucher, G. (Gabrielle), Britton, A. R. (Annie R.), Christophersen, I. E. (Ingrid E.), Dietrich, A. (Andrea), Ehret, G. B. (George B.), Ellinor, P. T. (Patrick T.), Eskola, M. (Markku), Felix, J. F. (Janine F.), Floras, J. S. (John S.), Franco, O. H. (Oscar H.), Friberg, P. (Peter), Gademan, M. G. (Maaike G. J.), Geyer, M. A. (Mark A.), Giedraitis, V. (Vilmantas), Hartman, C. A. (Catharina A.), Hemerich, D. (Daiane), Hofman, A. (Albert), Hottenga, J.-J. (Jouke-Jan), Huikuri, H. (Heikki), Hutri-Kähönen, N. (Nina), Jouven, X. (Xavier), Junttila, J. (Juhani), Juonala, M. (Markus), Kiviniemi, A. M. (Antti M.), Kors, J. A. (Jan A.), Kumari, M. (Meena), Kuznetsova, T. (Tatiana), Laurie, C. C. (Cathy C.), Lefrandt, J. D. (Joop D.), Li, Y. (Yong), Li, Y. (Yun), Liao, D. (Duanping), Limacher, M. C. (Marian C.), Lin, H. J. (Henry J.), Lindgren, C. M. (Cecilia M.), Lubitz, S. A. (Steven A.), Mahajan, A. (Anubha), McKnight, B. (Barbara), zu Schwabedissen, H. M. (Henriette Meyer), Milaneschi, Y. (Yuri), Mononen, N. (Nina), Morris, A. P. (Andrew P.), Nalls, M. A. (Mike A.), Navis, G. (Gerjan), Neijts, M. (Melanie), Nikus, K. (Kjell), North, K. E. (Kari E.), O'Connor, D. T. (Daniel T.), Ormel, J. (Johan), Perz, S. (Siegfried), Peters, A. (Annette), Psaty, B. M. (Bruce M.), Raitakari, O. T. (Olli T.), Risbrough, V. B. (Victoria B.), Sinner, M. F. (Moritz F.), Siscovick, D. (David), Smit, J. H. (Johannes H.), Smith, N. L. (Nicholas L.), Soliman, E. Z. (Elsayed Z.), Sotoodehnia, N. (Nona), Staessen, J. A. (Jan A.), Stein, P. K. (Phyllis K.), Stilp, A. M. (Adrienne M.), Stolarz-Skrzypek, K. (Katarzyna), Strauch, K. (Konstantin), Sundström, J. (Johan), Swenne, C. A. (Cees A.), Syvänen, A.-C. (Ann-Christine), Tardif, J.-C. (Jean-Claude), Taylor, K. D. (Kent D.), Teumer, A. (Alexander), Thornton, T. A. (Timothy A.), Tinker, L. E. (Lesley E.), Uitterlinden, A. G. (Andre G.), van Setten, J. (Jessica), Voss, A. (Andreas), Waldenberger, M. (Melanie), Wilhelmsen, K. C. (Kirk C.), Willemsen, G. (Gonneke), Wong, Q. (Quenna), Zhang, Z.-M. (Zhu-Ming), Zonderman, A. B. (Alan B.), Cusi, D. (Daniele), Evans, M. K. (Michele K.), Greiser, H. K. (Halina K.), van der Harst, P. (Pim), Hassan, M. (Mohammad), Ingelsson, E. (Erik), Järvelin, M.-R. (Marjo-Riitta), Kaab, S. (Stefan), Kähönen, M. (Mika), Kivimäki, M. (Mika), Kooperberg, C. (Charles), Kuh, D. (Diana), Lehtimäki, T. (Terho), Lind, L. (Lars), Nievergelt, C. M. (Caroline M.), O'Donnell, C. J. (Chris J.), Oldehinkel, A. J. (Albertine J.), Penninx, B. (Brenda), Reiner, A. P. (Alexander P.), Riese, H. (Harriette), van Roon, A. M. (Arie M.), Rioux, J. D. (John D.), Rotter, J. I. (Jerome I.), Sofer, T. (Tamar), Stricker, B. H. (Bruno H.), Tiemeier, H. (Henning), Vrijkotte, T. G. (Tanja G. M.), Asselbergs, F. W. (Folkert W.), Brundel, B. J. (Bianca J. J. M.), Heckbert, S. R. (Susan R.), Whitsel, E. A. (Eric A.), den Hoed, M. (Marcel), Snieder, H. (Harold), and de Geus, E. J. (Eco J. C.)

Abstract

Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide association studies for three HRV traits in up to 53,174 individuals of European ancestry, we detect 17 genome-wide significant SNPs in eight loci. HRV SNPs tag non-synonymous SNPs (in NDUFA11 and KIAA1755), expression quantitative trait loci (eQTLs) (influencing GNG11, RGS6 and NEO1), or are located in genes preferentially expressed in the sinoatrial node (GNG11, RGS6 and HCN4). Genetic risk scores account for 0.9 to 2.6% of the HRV variance. Significant genetic correlation is found for HRV with heart rate (-0.74

Published
2017

35. Coronary revascularization in patients that become stable

Author

MANFRINI, OLIVIA, PIZZI, CARMINE, BUGIARDINI, RAFFAELE, Eskola M., Karhunen P., Xhyheri B., Niemela K., Huhtala H., Nikus K., Manfrini O., Eskola M., Karhunen P., Xhyheri B., Niemela K., Pizzi C., Huhtala H., Nikus K., and Bugiardini R.

Subjects
CORONARY REVASCULARIZATION
Published
2012

38. Global Challenges and Solutions in the early Warning, Monitoring and Toxicity Assessment of Biotoxins in the Food and Feed Chain

Author

Rudolf Krska, Eskola Mari, BERTHILLER Franz, NIELEN Michel, OSWALD Isabelle, ELLIOTT Chris, MCNERNEY Oonagh, BOTANALUIS Miguel, and MALACHOVÁ Alexandra

Subjects
food and feed safety, prediction, early warning, phycotoxins, mycotoxins, plant toxins, Food processing and manufacture, TP368-456, Nutrition. Foods and food supply, TX341-641
Abstract

There is a massive and urgent need to ensure safety and security of the food supply of the world´s growing population. However, global agriculture and food industries continue to be vulnerable to problems of contamination with biotoxins produced by plants, algae and particularly by fungi; with global warming and extreme weather events making the occurrence of these toxic metabolites even more unpredictable. In this paper we summarize the multidisciplinary, multi-sectoral complementary competencies needed to innovate in various scientific fields and approaches, so strongly needed to develop improved early warning,monitoring and toxicity assessment of biotoxins in the food and feed chain. These include big data approaches using satellite and drone images, portable monitoring devices and (combined) toxicity testing of(emerging) biotoxins using proteomics and transcriptomics.

Published
2021
Full Text
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40. Genetic polymorphisms in Utsjoki Lapps

Author

Eskola, M.-R., primary, Kirjarinta, M., additional, Nijenhuis, L.E., additional, van den Berg-Loonen, E., additional, van Loghem, E., additional, Isokoski, M., additional, Sabi, T., additional, and Eriksson, A.W., additional

Published
1976
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41. Speed and Position Sensorless Control of Permanent Magnet Synchronous Motor in Matrix Converter and Voltage Source Converter Applications

Author

Eskola, M., Tehoelektroniikka - Tehoelektroniikka, and Sähkötekniikan osasto - Department of Elecrical Engineering

Abstract

In this thesis the sensorless control of a permanent magnet synchronous motor (PMSM) is studied. The study has two main purposes. The first is to find a simple and effective method to estimate the rotor position and angular speed of the PMSM. The second is to test the applicability of a matrix converter in sensorless PMSM drives. A matrix converter (MC) enables a direct frequency conversion without DC-link with energy storage. In this thesis two matrix converter topologies, direct and indirect, are studied. The vector modulation and the current commutation strategies of a matrix converter are described. Non-ideal properties of frequency converters such as dead times, overlapping times and voltage losses over semiconductors are disturbances for a control system and position estimator. These non-idealities are studied and the properties of a conventional voltage source inverter are compared to direct and indirect MC topologies. The rotor position and angular speed of the PMSM can be estimated by various methods. Estimators can be divided into model based estimators and signal injection estimators. Model based estimators calculate mechanical quantities using the mathematical representation of the motor. Injection methods usually exploit the saliency of the PMSM. Injected voltage creates currents which are modulated by the rotor position. The position information can be extracted from measured currents. In this thesis the best features of model based and injection estimators are combined. In the proposed hybrid method signal injection is used at low speeds and the transition to model based estimator is performed when the speed increases. The estimator methods used in the hybrid estimator are selected by a comparative analysis and simulations. The most important criteria in the selection of the estimator method in this thesis are: simple algorithm and no need for modification of the modulator software or frequency converter. The suitability of the proposed hybrid estimator is tested by simulations and experimental tests in various operating conditions. To test the performance of the matrix converter the experiments are carried out using both MC topologies and a conventional voltage source converter. The results obtained show that a matrix converter can be used in PMSM drives where the speed and position of the PMSM are not measured. The proposed estimator method is stable over the nominal speed range including the zero speed region with full load torque.

Published
2006

48. Randomized comparison of final kissing balloon dilatation versus no final kissing balloon dilatation in patients with coronary bifurcation lesions treated with main vessel stenting: the Nordic-Baltic Bifurcation Study III.

Author

Niemelä M, Kervinen K, Erglis A, Holm NR, Maeng M, Christiansen EH, Kumsars I, Jegere S, Dombrovskis A, Gunnes P, Stavnes S, Steigen TK, Trovik T, Eskola M, Vikman S, Romppanen H, Mäkikallio T, Hansen KN, Thayssen P, and Aberge L

Published
2011
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