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4 results on '"F.G. Larsen"'

1. A Study of the Safety and Efficacy of Calcipotriol and Betamethasone Dipropionate Scalp Formulation in the Long-Term Management of Scalp Psoriasis

Author

P. Kidson, Neil H. Shear, F. Clonier, T.A. Luger, F. Cambazard, G. Gupta, F.G. Larsen, and M. Bourcier

Subjects
Adult, Male, Canada, medicine.medical_specialty, Adolescent, Denmark, Anti-Inflammatory Agents, Betamethasone dipropionate, Dermatology, Administration, Cutaneous, Betamethasone, Severity of Illness Index, law.invention, Ointments, chemistry.chemical_compound, Calcitriol, Double-Blind Method, Randomized controlled trial, law, Germany, Psoriasis, Long term management, medicine, Humans, Prospective Studies, Calcipotriol, Aged, Aged, 80 and over, Scalp, business.industry, Pharmacology and Treatment, Middle Aged, medicine.disease, United Kingdom, Drug Combinations, Treatment Outcome, medicine.anatomical_structure, chemistry, Female, Dermatologic Agents, France, Pharmaceutical Vehicles, business, Scalp psoriasis, medicine.drug
Abstract

Background: Effective and safe products are needed for long-term management of scalp psoriasis. This study investigated the long-term safety and efficacy of a two-compound formulation (calcipotriol 50 µg/g plus betamethasone dipropionate 0.5 mg/g) for scalp psoriasis. Methods: In this 52-week, international, double-blind study, 869 patients with moderate-to-severe scalp psoriasis were randomized to either a two-compound scalp formulation (n = 429) or calcipotriol (n = 440). Results: Adverse drug reactions were less frequent in the two-compound group compared with the calcipotriol group (17.2 vs. 29.5%; p < 0.001). Incidences of adverse events possibly associated with long-term corticosteroid use were low in both the two-compound (2.6%) and the calcipotriol (3.0%) groups. Disease was satisfactorily controlled in 92.3% of visits in the two-compound group versus 80.0% in the calcipotriol group (p < 0.001). Conclusion: The two-compound scalp formulation demonstrated a high level of safety and efficacy in long-term management of scalp psoriasis.

Published
2008
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2. Safety and efficacy of combined high-dose treatment with calcipotriol ointment and solution in patients with psoriasis

Author

Peter E. Hutchinson, D.M. Tillman, F.G. Larsen, C. Green, K.J. Hamberg, C.S. Munro, P. Kidson, Knud Kragballe, P.C.M. van de Kerkhof, and J.K. Jensen

Subjects
Adult, Male, medicine.medical_specialty, Calcitriol, medicine.medical_treatment, Administration, Topical, Dermatology, Severity of Illness Index, law.invention, Ointments, chemistry.chemical_compound, Pharmacotherapy, Randomized controlled trial, law, Psoriasis, Medicine, Humans, Calcipotriol, Aged, Probability, Chemotherapy, Analysis of Variance, Dose-Response Relationship, Drug, business.industry, Epidermal differentiation and cutaneous inflammation, Anthralin, Middle Aged, medicine.disease, Surgery, Clinical trial, Solutions, medicine.anatomical_structure, Treatment Outcome, chemistry, Scalp, Epidermale differentiatie en cutane ontstekingsprocessen, Drug Therapy, Combination, Female, business, medicine.drug, Follow-Up Studies
Abstract

Background: In the vast majority of psoriatic patients, psoriatic lesions are localised on the body as well as on the scalp. Therefore, safety data on the combined use of calcipotriol in lotion and calcipotriol in ointment are needed. Objective: This study investigated the effect of high-dose treatment with a combination of calcipotriol ointment and scalp solution on calcium metabolism, indices of bone turnover and PASI in patients with extensive psoriasis. Methods: Following a 2-week wash-out period, 88 patients were randomised to 4 weeks of treatment with either calcipotriol ointment/scalp solution (80–100 g/week and 30–50 ml/week, respectively; n = 41) or with a dithranol/tar regimen (n = 47). Patients were seen at weeks 1, 2 and 4 during treatment and 1 week following cessation of treatment. Results: No significant differences at the end of treatment were found between the 2 groups with respect to 24-hour urinary excretion of calcium (expressed as calcium/creatinine ratio), phosphate or pyridinoline, serum concentrations of calcium (albumin corrected), creatinine, phosphate, parathyroid hormone, 25-hydroxyvitamin D3, 1,25-dihydroxyvitamin D3, osteocalcin, alkaline phosphatase (total and bone-specific iso-enzymes) or 1-collagen telopeptide. At the end of treatment, the psoriasis area and severity index had decreased by 57.4% in the calcipotriol group and by 36.1% in the dithranol/tar group (p = 0.004). Investigators’ and patients’ assessments of overall efficacy also favoured treatment with calcipotriol (p < 0.001). Conclusion: The combined use of calcipotriol ointment/scalp solution did not affect the indices of calcium metabolism or bone turnover and was significantly more effective than dithranol/tar in reducing disease severity and extent in patients with extensive psoriasis.

Published
2002

3. Subject Index Vol. 217, 2008

Author

Josep Malvehy, F. Berard, Mauro Picardo, Carlo Tomino, Natalija Novak, Eugenia Caggese, Tetsuya Higuchi, Cataldo Patruno, Michiie Sakamoto, G. Safa, Pablo F. Peñas, T.A. Luger, Thomas Bieber, Knut Schäkel, G. Gupta, Daniele Torchia, Thomas Ruzicka, Susana Puig, N. Okiyama, Emilio Pedrosa, Renato G. Panizzon, M. Loppin, Mario Arico, Lucia Gallo, Michael Meurer, Paola Bertuccio, Masayuki Kimoto, Paula Aguilera, Abdul-Ghani Kibbi, Uta Schwanebeck, Carmelo Urso, Anna Balato, Alexander V. Kuznetsov, Rosanna Cuscito, María Jones-Caballero, Mirjana Urosevic, Peter Weisenseel, J. Lamoril, N.H. Shear, Masaru Tanaka, I. Katayama, T. Satoh, Luca Borradori, B. Ben-Said, Ghassan Awar, Fabio Ayala, F.G. Larsen, Joerg C. Prinz, Nicola Balato, Reinhard Dummer, K. Nishioka, Mazen Kurban, Shigeki Inui, L. Tisseau, O. Lejeune, Liliane Chatenoud, J.F. Nicolas, Patrick A. Oberholzer, Carola Berking, Antonio Addis, Hans C. Steinert, Samer Ghosn, Hiroo Yokozeki, Gabriel Salerni, Y. Chaves, Dagmar Wilsmann-Theis, Alberto Giannetti, P. Kidson, Maria Rita Bongiorno, Cristina Carrera, Marlies Wakkee, Giovanni Maria Palleschi, Zenus Saleh, N. Ueda, M. Bourcier, Takahiro Satoh, Xina Grählert, F. Cambazard, Satoshi Itami, Sergio Chimenti, G. Duarte, Anastasia A. Garrido-Ríos, Sonja Molin, Mara Maccarone, H. Yokozeki, Eugenio Torre, T. Simonart, Luigi Naldi, Hitoshi Iyatomi, F. Clonier, Jochen Schmitt, Emmanuel Laffitte, J. Tebib, Tamar Nijsten, Takeshi Nakajima, and H. Kohsaka

Subjects
Index (economics), Statistics, Subject (documents), Dermatology, Mathematics
Published
2008
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4. Acknowledgement to Referees for Dermatology 2008

Author

Pablo F. Peñas, T.A. Luger, María Jones-Caballero, G. Duarte, Emmanuel Laffitte, N. Okiyama, F. Clonier, Anastasia A. Garrido-Ríos, J. Tebib, Carola Berking, N. Ueda, Tamar Nijsten, Thomas Bieber, G. Gupta, Alberto Giannetti, Carmelo Urso, Sonja Molin, M. Bourcier, Samer Ghosn, Rosanna Cuscito, K. Nishioka, Dagmar Wilsmann-Theis, J.F. Nicolas, Takeshi Nakajima, T. Satoh, Satoshi Itami, T. Simonart, Mara Maccarone, H. Yokozeki, Natalija Novak, Maria Rita Bongiorno, Eugenio Torre, Paula Aguilera, Mirjana Urosevic, Cataldo Patruno, Hiroo Yokozeki, Sergio Chimenti, Knut Schäkel, Michiie Sakamoto, Paola Bertuccio, Gabriel Salerni, F. Cambazard, Peter Weisenseel, Y. Chaves, Shigeki Inui, I. Katayama, Luigi Naldi, O. Lejeune, Zenus Saleh, Antonio Addis, Masayuki Kimoto, Hitoshi Iyatomi, Fabio Ayala, Liliane Chatenoud, Jochen Schmitt, Anna Balato, F.G. Larsen, Takahiro Satoh, H. Kohsaka, L. Tisseau, Mazen Kurban, Reinhard Dummer, Uta Schwanebeck, Carlo Tomino, Giovanni Maria Palleschi, Daniele Torchia, Susana Puig, Thomas Ruzicka, Renato G. Panizzon, Alexander V. Kuznetsov, Nicola Balato, P. Kidson, Cristina Carrera, Patrick A. Oberholzer, Marlies Wakkee, Mauro Picardo, Emilio Pedrosa, Mario Arico, Lucia Gallo, Masaru Tanaka, N.H. Shear, Joerg C. Prinz, G. Safa, Abdul-Ghani Kibbi, J. Lamoril, M. Loppin, Xina Grählert, Michael Meurer, Luca Borradori, B. Ben-Said, Ghassan Awar, Hans C. Steinert, Eugenia Caggese, Tetsuya Higuchi, Josep Malvehy, and F. Berard

Subjects
Medical education, Acknowledgement, Dermatology, Psychology
Published
2008
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