1. Newly Explored Faecalibacterium Diversity Is Connected to Age, Lifestyle, Geography, and Disease
- Author
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Danilo Ercolini, Edoardo Pasolli, Francesca De Filippis, DE FILIPPIS, Francesca, Pasolli, Edoardo, and Ercolini, Danilo
- Subjects
Adult ,0301 basic medicine ,Adolescent ,media_common.quotation_subject ,Datasets as Topic ,Faecalibacterium prausnitzii ,Disease ,Biology ,Genome ,General Biochemistry, Genetics and Molecular Biology ,Feces ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Human gut ,Animals ,Humans ,Child ,Life Style ,Faecalibacterium ,Phylogeny ,Aged ,media_common ,Geography ,Probiotics ,Age Factors ,Infant ,Middle Aged ,biology.organism_classification ,Gut microbiome ,Gastrointestinal Microbiome ,Faecalibacterium prausnitzii, gut microbiome, strain diversity, pangenome, novel probiotics, biotherapeutics ,030104 developmental biology ,Evolutionary biology ,Child, Preschool ,Dysbiosis ,Macaca ,Metagenome ,Metagenomics ,General Agricultural and Biological Sciences ,030217 neurology & neurosurgery ,Diversity (politics) - Abstract
Faecalibacterium is prevalent in the human gut and a promising microbe for the development of next-generation probiotics (NGPs) or biotherapeutics. Analyzing reference Faecalibacterium genomes and almost 3,000 Faecalibacterium-like metagenome-assembled genomes (MAGs) reconstructed from 7,907 human and 203 non-human primate gut metagenomes, we identified the presence of 22 different Faecalibacterium-like species-level genome bins (SGBs), some further divided in different strains according to the subject geographical origin. Twelve SGBs are globally spread in the human gut and show different genomic potential in the utilization of complex polysaccharides, suggesting that higher SGB diversity may be related with increased utilization of plant-based foods. Moreover, up to 11 different species may co-occur in the same subject, with lower diversity in Western populations, as well as intestinal inflammatory states and obesity. The newly explored Faecalibacterium diversity will be able to support the choice of strains suitable as NGPs, guided by the consideration of the differences existing in their functional potential.
- Published
- 2020