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2. Synthesis, Characterization and Antitumor Activity of Some New Oganotellurium Compounds Containing Azomethine Group, Part One

Author

Al-Asadi, Rafid H., Fahad, Tarik A., Saeed, Bahjat A., Al-Masoudi, Wasfi A., Al-Asadi, Rafid H., Fahad, Tarik A., Saeed, Bahjat A., and Al-Masoudi, Wasfi A.

Abstract

New tellurated schiff bases were synthesized by the reaction of the corresponding mercurated Schiff  bases compounds A1-A3 with tellurium tetrabromide in 1:1 mole ratio and  that  gave organyltellurium tribromides  A4-A6.  On the other hand, when mercurated schiff bases and tellurium tetrabromide brought  together in 2:1 mole ratio gave diorganyltellurium dibromides compounds A10-A12 followed by reduction with hydrazine hydrate gave new diorganyl tellurides A13-A15. Reduction of compounds A4-A6 by hydrazine hydrate gave new ditellurides A7-A9.  All compounds were characterized by elemental analysis, IR, 1H , 13C NMR, HSQC-NMR and mass spectra. Invitro anti-tumor bioactivity of some compounds were tested.Â

Published
2016

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