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1. Intratumoral Immunotherapy: Is It Ready for Prime Time?

Author

Ghosn, Mario, Tselikas, Lambros, Champiat, Stéphane, Deschamps, Frederic, Bonnet, Baptiste, Carre, Émilie, Testan, Marine, Danlos, François-Xavier, Farhane, Siham, Susini, Sandrine, Suzzoni, Steve, Ammari, Samy, Marabelle, Aurélien, and De Baere, Thierry

Published
2023
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2. Protective effect of obesity on survival in cancers treated with immunotherapy vanishes when controlling for type of cancer, weight loss and reduced skeletal muscle

Author

Antoun, Sami, Lanoy, Emilie, Ammari, Samy, Farhane, Siham, Martin, Lisa, Robert, Caroline, Planchard, David, Routier, Emilie, Voisin, Anne Laure, Messayke, Sabine, Champiat, Stephane, Michot, Jean Marie, Laghouati, Salim, Lambotte, Olivier, Marabelle, Aurélien, and Baracos, Vickie

Published
2023
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3. Feasibility, safety and efficacy of human intra-tumoral immuno-therapy. Gustave Roussy's initial experience with its first 100 patients

Author

Tselikas, Lambros, Dardenne, Antoine, de Baere, Thierry, Faron, Matthieu, Ammari, Samy, Farhane, Siham, Suzzoni, Steve, Danlos, François-Xavier, Raoult, Thibault, Susini, Sandrine, Al Shatti, Nael, Mouraud, Severine, Deschamps, Frédéric, Kobe, Adrian, Delpla, Alexandre, Roux, Charles, Baldini, Capucine, Soria, Jean-Charles, Barlesi, Fabrice, Massard, Christophe, Robert, Caroline, Champiat, Stéphane, and Marabelle, Aurélien

Published
2022
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4. Safety, recommended dose, efficacy and immune correlates for nintedanib in combination with pembrolizumab in patients with advanced cancers

Author

Baldini, Capucine, Danlos, Francois-Xavier, Varga, Andreea, Texier, Matthieu, Halse, Heloise, Mouraud, Severine, Cassard, Lydie, Champiat, Stéphane, Signolle, Nicolas, Vuagnat, Perrine, Martin-Romano, Patricia, Michot, Jean-Marie, Bahleda, Rastislav, Gazzah, Anas, Boselli, Lisa, Bredel, Delphine, Grivel, Jonathan, Mohamed-Djalim, Chifaou, Escriou, Guillaume, Grynszpan, Laetitia, Bigorgne, Amelie, Rafie, Saloomeh, Abbassi, Alae, Ribrag, Vincent, Postel-Vinay, Sophie, Hollebecque, Antoine, Susini, Sandrine, Farhane, Siham, Lacroix, Ludovic, Parpaleix, Aurelien, Laghouati, Salim, Zitvogel, Laurence, Adam, Julien, Chaput, Nathalie, Soria, Jean-Charles, Massard, Christophe, and Marabelle, Aurelien

Published
2022
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5. Human virome profiling identified CMV as the major viral driver of a high accumulation of senescent CD8 + T cells in patients with advanced NSCLC

Author

Naigeon, Marie, primary, Roulleaux Dugage, Matthieu, additional, Danlos, François-Xavier, additional, Boselli, Lisa, additional, Jouniaux, Jean-Mehdi, additional, de Oliveira, Caroline, additional, Ferrara, Roberto, additional, Duchemann, Boris, additional, Berthot, Caroline, additional, Girard, Lou, additional, Flippot, Ronan, additional, Albiges, Laurence, additional, Farhane, Siham, additional, Saulnier, Patrick, additional, Lacroix, Ludovic, additional, Griscelli, Frank, additional, Roman, Gabriel, additional, Hulett, Tyler, additional, Marabelle, Aurélien, additional, Cassard, Lydie, additional, Besse, Benjamin, additional, and Chaput, Nathalie, additional

Published
2023
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6. Synergic prognostic value of 3D CT scan subcutaneous fat and muscle masses for immunotherapy-treated cancer

Author

Decazes, Pierre, primary, Ammari, Samy, additional, Belkouchi, Younes, additional, Mottay, Léo, additional, Lawrance, Littisha, additional, de Prévia, Antoine, additional, Talbot, Hugues, additional, Farhane, Siham, additional, Cournède, Paul-Henry, additional, Marabelle, Aurelien, additional, Guisier, Florian, additional, Planchard, David, additional, Ibrahim, Tony, additional, Robert, Caroline, additional, Barlesi, Fabrice, additional, Vera, Pierre, additional, and Lassau, Nathalie, additional

Published
2023
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7. Supplementary Figure S5 from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy

Author

Belkouchi, Younes, primary, Talbot, Hugues, primary, Lassau, Nathalie, primary, Lawrance, Littisha, primary, Farhane, Siham, primary, Feki-Mkaouar, Rahma, primary, Hadchiti, Joya, primary, Dawi, Lama, primary, Vibert, Julien, primary, Cournède, Paul-Henry, primary, Cousteix, Clara, primary, Mazza, Camille, primary, Kind, Michele, primary, Italiano, Antoine, primary, Marabelle, Aurelien, primary, Ammari, Samy, primary, and Champiat, Stephane, primary

Published
2023
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8. Data from Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy

Author

Belkouchi, Younes, primary, Talbot, Hugues, primary, Lassau, Nathalie, primary, Lawrance, Littisha, primary, Farhane, Siham, primary, Feki-Mkaouar, Rahma, primary, Hadchiti, Joya, primary, Dawi, Lama, primary, Vibert, Julien, primary, Cournède, Paul-Henry, primary, Cousteix, Clara, primary, Mazza, Camille, primary, Kind, Michele, primary, Italiano, Antoine, primary, Marabelle, Aurelien, primary, Ammari, Samy, primary, and Champiat, Stephane, primary

Published
2023
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9. Supplementary Table S4 from Genomic Instability and Protumoral Inflammation Are Associated with Primary Resistance to Anti–PD-1 + Antiangiogenesis in Malignant Pleural Mesothelioma

Author

Danlos, François-Xavier, primary, Texier, Matthieu, primary, Job, Bastien, primary, Mouraud, Severine, primary, Cassard, Lydie, primary, Baldini, Capucine, primary, Varga, Andrea, primary, Yurchenko, Andrey A., primary, Rabeau, Audrey, primary, Champiat, Stéphane, primary, Letourneur, Diane, primary, Bredel, Delphine, primary, Susini, Sandrine, primary, Blum, Yuna, primary, Parpaleix, Aurelien, primary, Parlavecchio, Cedric, primary, Tselikas, Lambros, primary, Fahrner, Jean-Eudes, primary, Goubet, Anne-Gaelle, primary, Rouanne, Mathieu, primary, Rafie, Saloomeh, primary, Abbassi, Alae, primary, Kasraoui, Ines, primary, Breckler, Marie, primary, Farhane, Siham, primary, Ammari, Samy, primary, Laghouati, Salim, primary, Gazzah, Anas, primary, Lacroix, Ludovic, primary, Besse, Benjamin, primary, Droin, Nathalie, primary, Deloger, Marc, primary, Cotteret, Sophie, primary, Adam, Julien, primary, Zitvogel, Laurence, primary, Nikolaev, Sergey I., primary, Chaput, Nathalie, primary, Massard, Christophe, primary, Soria, Jean-Charles, primary, Gomez-Roca, Carlos, primary, Zalcman, Gerard, primary, Planchard, David, primary, and Marabelle, Aurelien, primary

Published
2023
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10. Supplementary Figure S5 from Genomic Instability and Protumoral Inflammation Are Associated with Primary Resistance to Anti–PD-1 + Antiangiogenesis in Malignant Pleural Mesothelioma

Author

Danlos, François-Xavier, primary, Texier, Matthieu, primary, Job, Bastien, primary, Mouraud, Severine, primary, Cassard, Lydie, primary, Baldini, Capucine, primary, Varga, Andrea, primary, Yurchenko, Andrey A., primary, Rabeau, Audrey, primary, Champiat, Stéphane, primary, Letourneur, Diane, primary, Bredel, Delphine, primary, Susini, Sandrine, primary, Blum, Yuna, primary, Parpaleix, Aurelien, primary, Parlavecchio, Cedric, primary, Tselikas, Lambros, primary, Fahrner, Jean-Eudes, primary, Goubet, Anne-Gaelle, primary, Rouanne, Mathieu, primary, Rafie, Saloomeh, primary, Abbassi, Alae, primary, Kasraoui, Ines, primary, Breckler, Marie, primary, Farhane, Siham, primary, Ammari, Samy, primary, Laghouati, Salim, primary, Gazzah, Anas, primary, Lacroix, Ludovic, primary, Besse, Benjamin, primary, Droin, Nathalie, primary, Deloger, Marc, primary, Cotteret, Sophie, primary, Adam, Julien, primary, Zitvogel, Laurence, primary, Nikolaev, Sergey I., primary, Chaput, Nathalie, primary, Massard, Christophe, primary, Soria, Jean-Charles, primary, Gomez-Roca, Carlos, primary, Zalcman, Gerard, primary, Planchard, David, primary, and Marabelle, Aurelien, primary

Published
2023
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11. Data from Genomic Instability and Protumoral Inflammation Are Associated with Primary Resistance to Anti–PD-1 + Antiangiogenesis in Malignant Pleural Mesothelioma

Author

Danlos, François-Xavier, primary, Texier, Matthieu, primary, Job, Bastien, primary, Mouraud, Severine, primary, Cassard, Lydie, primary, Baldini, Capucine, primary, Varga, Andrea, primary, Yurchenko, Andrey A., primary, Rabeau, Audrey, primary, Champiat, Stéphane, primary, Letourneur, Diane, primary, Bredel, Delphine, primary, Susini, Sandrine, primary, Blum, Yuna, primary, Parpaleix, Aurelien, primary, Parlavecchio, Cedric, primary, Tselikas, Lambros, primary, Fahrner, Jean-Eudes, primary, Goubet, Anne-Gaelle, primary, Rouanne, Mathieu, primary, Rafie, Saloomeh, primary, Abbassi, Alae, primary, Kasraoui, Ines, primary, Breckler, Marie, primary, Farhane, Siham, primary, Ammari, Samy, primary, Laghouati, Salim, primary, Gazzah, Anas, primary, Lacroix, Ludovic, primary, Besse, Benjamin, primary, Droin, Nathalie, primary, Deloger, Marc, primary, Cotteret, Sophie, primary, Adam, Julien, primary, Zitvogel, Laurence, primary, Nikolaev, Sergey I., primary, Chaput, Nathalie, primary, Massard, Christophe, primary, Soria, Jean-Charles, primary, Gomez-Roca, Carlos, primary, Zalcman, Gerard, primary, Planchard, David, primary, and Marabelle, Aurelien, primary

Published
2023
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12. Table S3 from Circulating T-cell Immunosenescence in Patients with Advanced Non–small Cell Lung Cancer Treated with Single-agent PD-1/PD-L1 Inhibitors or Platinum-based Chemotherapy

Author

Ferrara, Roberto, primary, Naigeon, Marie, primary, Auclin, Edouard, primary, Duchemann, Boris, primary, Cassard, Lydie, primary, Jouniaux, Jean-Mehdi, primary, Boselli, Lisa, primary, Grivel, Jonathan, primary, Desnoyer, Aude, primary, Mezquita, Laura, primary, Texier, Matthieu, primary, Caramella, Caroline, primary, Hendriks, Lizza, primary, Planchard, David, primary, Remon, Jordi, primary, Sangaletti, Sabina, primary, Proto, Claudia, primary, Garassino, Marina C., primary, Soria, Jean-Charles, primary, Marabelle, Aurelien, primary, Voisin, Anne-Laure, primary, Farhane, Siham, primary, Besse, Benjamin, primary, and Chaput, Nathalie, primary

Published
2023
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13. Supplementary Methods from Circulating T-cell Immunosenescence in Patients with Advanced Non–small Cell Lung Cancer Treated with Single-agent PD-1/PD-L1 Inhibitors or Platinum-based Chemotherapy

Author

Ferrara, Roberto, primary, Naigeon, Marie, primary, Auclin, Edouard, primary, Duchemann, Boris, primary, Cassard, Lydie, primary, Jouniaux, Jean-Mehdi, primary, Boselli, Lisa, primary, Grivel, Jonathan, primary, Desnoyer, Aude, primary, Mezquita, Laura, primary, Texier, Matthieu, primary, Caramella, Caroline, primary, Hendriks, Lizza, primary, Planchard, David, primary, Remon, Jordi, primary, Sangaletti, Sabina, primary, Proto, Claudia, primary, Garassino, Marina C., primary, Soria, Jean-Charles, primary, Marabelle, Aurelien, primary, Voisin, Anne-Laure, primary, Farhane, Siham, primary, Besse, Benjamin, primary, and Chaput, Nathalie, primary

Published
2023
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14. Figure S4 from Circulating T-cell Immunosenescence in Patients with Advanced Non–small Cell Lung Cancer Treated with Single-agent PD-1/PD-L1 Inhibitors or Platinum-based Chemotherapy

Author

Ferrara, Roberto, primary, Naigeon, Marie, primary, Auclin, Edouard, primary, Duchemann, Boris, primary, Cassard, Lydie, primary, Jouniaux, Jean-Mehdi, primary, Boselli, Lisa, primary, Grivel, Jonathan, primary, Desnoyer, Aude, primary, Mezquita, Laura, primary, Texier, Matthieu, primary, Caramella, Caroline, primary, Hendriks, Lizza, primary, Planchard, David, primary, Remon, Jordi, primary, Sangaletti, Sabina, primary, Proto, Claudia, primary, Garassino, Marina C., primary, Soria, Jean-Charles, primary, Marabelle, Aurelien, primary, Voisin, Anne-Laure, primary, Farhane, Siham, primary, Besse, Benjamin, primary, and Chaput, Nathalie, primary

Published
2023
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15. Supplementary Figure S1 from Interventional Radiology for Local Immunotherapy in Oncology

Author

Tselikas, Lambros, primary, Champiat, Stephane, primary, Sheth, Rahul A., primary, Yevich, Steve, primary, Ammari, Samy, primary, Deschamps, Frederic, primary, Farhane, Siham, primary, Roux, Charles, primary, Susini, Sandrine, primary, Mouraud, Severine, primary, Delpla, Alexandre, primary, Raoult, Thibault, primary, Robert, Caroline, primary, Massard, Christophe, primary, Barlesi, Fabrice, primary, Soria, Jean-Charles, primary, Marabelle, Aurélien, primary, and de Baere, Thierry, primary

Published
2023
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16. Supplementary Video S1 from Interventional Radiology for Local Immunotherapy in Oncology

Author

Tselikas, Lambros, primary, Champiat, Stephane, primary, Sheth, Rahul A., primary, Yevich, Steve, primary, Ammari, Samy, primary, Deschamps, Frederic, primary, Farhane, Siham, primary, Roux, Charles, primary, Susini, Sandrine, primary, Mouraud, Severine, primary, Delpla, Alexandre, primary, Raoult, Thibault, primary, Robert, Caroline, primary, Massard, Christophe, primary, Barlesi, Fabrice, primary, Soria, Jean-Charles, primary, Marabelle, Aurélien, primary, and de Baere, Thierry, primary

Published
2023
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17. Better than RECIST and Faster than iRECIST: Defining the Immunotherapy Progression Decision Score to Better Manage Progressive Tumors on Immunotherapy

Author

Belkouchi, Younes, primary, Talbot, Hugues, additional, Lassau, Nathalie, additional, Lawrance, Littisha, additional, Farhane, Siham, additional, Feki-Mkaouar, Rahma, additional, Hadchiti, Joya, additional, Dawi, Lama, additional, Vibert, Julien, additional, Cournède, Paul-Henry, additional, Cousteix, Clara, additional, Mazza, Camille, additional, Kind, Michele, additional, Italiano, Antoine, additional, Marabelle, Aurelien, additional, Ammari, Samy, additional, and Champiat, Stephane, additional

Published
2023
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18. Genomic Instability and Protumoral Inflammation Are Associated with Primary Resistance to Anti–PD-1 + Antiangiogenesis in Malignant Pleural Mesothelioma

Author

Danlos, François-Xavier, primary, Texier, Matthieu, additional, Job, Bastien, additional, Mouraud, Severine, additional, Cassard, Lydie, additional, Baldini, Capucine, additional, Varga, Andrea, additional, Yurchenko, Andrey A., additional, Rabeau, Audrey, additional, Champiat, Stéphane, additional, Letourneur, Diane, additional, Bredel, Delphine, additional, Susini, Sandrine, additional, Blum, Yuna, additional, Parpaleix, Aurelien, additional, Parlavecchio, Cedric, additional, Tselikas, Lambros, additional, Fahrner, Jean-Eudes, additional, Goubet, Anne-Gaelle, additional, Rouanne, Mathieu, additional, Rafie, Saloomeh, additional, Abbassi, Alae, additional, Kasraoui, Ines, additional, Breckler, Marie, additional, Farhane, Siham, additional, Ammari, Samy, additional, Laghouati, Salim, additional, Gazzah, Anas, additional, Lacroix, Ludovic, additional, Besse, Benjamin, additional, Droin, Nathalie, additional, Deloger, Marc, additional, Cotteret, Sophie, additional, Adam, Julien, additional, Zitvogel, Laurence, additional, Nikolaev, Sergey I., additional, Chaput, Nathalie, additional, Massard, Christophe, additional, Soria, Jean-Charles, additional, Gomez-Roca, Carlos, additional, Zalcman, Gerard, additional, Planchard, David, additional, and Marabelle, Aurelien, additional

Published
2023
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21. Additional file 2 of Safety, recommended dose, efficacy and immune correlates for nintedanib in combination with pembrolizumab in patients with advanced cancers

Author

Baldini, Capucine, Danlos, Francois-Xavier, Varga, Andreea, Texier, Matthieu, Halse, Heloise, Mouraud, Severine, Cassard, Lydie, Champiat, Stéphane, Signolle, Nicolas, Vuagnat, Perrine, Martin-Romano, Patricia, Michot, Jean-Marie, Bahleda, Rastislav, Gazzah, Anas, Boselli, Lisa, Bredel, Delphine, Grivel, Jonathan, Mohamed-Djalim, Chifaou, Escriou, Guillaume, Grynszpan, Laetitia, Bigorgne, Amelie, Rafie, Saloomeh, Abbassi, Alae, Ribrag, Vincent, Postel-Vinay, Sophie, Hollebecque, Antoine, Susini, Sandrine, Farhane, Siham, Lacroix, Ludovic, Parpaleix, Aurelien, Laghouati, Salim, Zitvogel, Laurence, Adam, Julien, Chaput, Nathalie, Soria, Jean-Charles, Massard, Christophe, and Marabelle, Aurelien

Abstract

Additional file 2: Supplementary Fig. 2. Evolution of plasma soluble cytokines between after the first pembrolizumab infusion, between cycle 1 and cycle 2. Tests were paired Wilcoxon signed rank test (paired samples) (representation of p-value: ns > 0.05, * ≤ 0.05). Abbreviations: PD = Progressive disease; SD = Stable disease; PR = Partial response; Ninte. = nintedanib; DCB = Durable clinical benefit; D-7 = day − 7; C1D1 = Cycle 1 day 1; MIP = Macrophage Inflammatory Protein; MCP1 = Monocyte Chemoattractant protein; MDC = Macrophage Derived Chemokine.

Published
2022
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22. Additional file 3 of Safety, recommended dose, efficacy and immune correlates for nintedanib in combination with pembrolizumab in patients with advanced cancers

Author

Baldini, Capucine, Danlos, Francois-Xavier, Varga, Andreea, Texier, Matthieu, Halse, Heloise, Mouraud, Severine, Cassard, Lydie, Champiat, Stéphane, Signolle, Nicolas, Vuagnat, Perrine, Martin-Romano, Patricia, Michot, Jean-Marie, Bahleda, Rastislav, Gazzah, Anas, Boselli, Lisa, Bredel, Delphine, Grivel, Jonathan, Mohamed-Djalim, Chifaou, Escriou, Guillaume, Grynszpan, Laetitia, Bigorgne, Amelie, Rafie, Saloomeh, Abbassi, Alae, Ribrag, Vincent, Postel-Vinay, Sophie, Hollebecque, Antoine, Susini, Sandrine, Farhane, Siham, Lacroix, Ludovic, Parpaleix, Aurelien, Laghouati, Salim, Zitvogel, Laurence, Adam, Julien, Chaput, Nathalie, Soria, Jean-Charles, Massard, Christophe, and Marabelle, Aurelien

Abstract

Additional file 3: Supplementary Fig. 3. Illustration of multiplex chromogenic staining dedicated to myeloid cells. A Representative image displays a 500umx669um image after multispectral imaging and spectral unmixing (merged image). B All markers. C CD68 (pseudocoloured white). D DAPI nuclear marker (pseudocoloured blue). E CD163 (pseudocoloured green). F DC-LAMP (pseudocoloured magenta). G IDO1 (pseudocoloured yellow). H CD163 measurement was undertaken using Inform v2.2 software segmentation by pixel-based threshold. I CD163+ density in biopsies of patients with DCB or without DCB at baseline and C2D1 were not significantly different (Wilcoxon rank-sum test).

Published
2022
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23. 277 Safety and efficacy of intratumoral ipilimumab with IV nivolumab in metastatic melanoma. The NIVIPIT trial

Author

Tselikas, Lambros, primary, Robert, Caroline, additional, Dalle, Stephane, additional, Meyer, Nicolas, additional, Lebbe, Celeste, additional, Ammari, Samy, additional, Danlos, François-Xavier, additional, Roy, Severine, additional, Jannin, Camille, additional, Farhane, Siham, additional, Mourad, Severine, additional, Escriou, Guillaume, additional, Raoult, Thibault, additional, Scoazec, Jean-Yves, additional, Texier, Matthieuu, additional, Chaput-Gras, Nathalie, additional, Zitvogel, Laurence, additional, Baere, Thierry De, additional, and Marabelle, Aurélien, additional

Published
2021
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24. Intratumoral Immunotherapy: From Trial Design to Clinical Practice

Author

Champiat, Stéphane, primary, Tselikas, Lambros, additional, Farhane, Siham, additional, Raoult, Thibault, additional, Texier, Matthieu, additional, Lanoy, Emilie, additional, Massard, Christophe, additional, Robert, Caroline, additional, Ammari, Samy, additional, De Baère, Thierry, additional, and Marabelle, Aurélien, additional

Published
2021
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25. Circulating T-cell Immunosenescence in Patients with Advanced Non–small Cell Lung Cancer Treated with Single-agent PD-1/PD-L1 Inhibitors or Platinum-based Chemotherapy

Author

Ferrara, Roberto, primary, Naigeon, Marie, additional, Auclin, Edouard, additional, Duchemann, Boris, additional, Cassard, Lydie, additional, Jouniaux, Jean-Mehdi, additional, Boselli, Lisa, additional, Grivel, Jonathan, additional, Desnoyer, Aude, additional, Mezquita, Laura, additional, Texier, Matthieu, additional, Caramella, Caroline, additional, Hendriks, Lizza, additional, Planchard, David, additional, Remon, Jordi, additional, Sangaletti, Sabina, additional, Proto, Claudia, additional, Garassino, Marina C., additional, Soria, Jean-Charles, additional, Marabelle, Aurelien, additional, Voisin, Anne-Laure, additional, Farhane, Siham, additional, Besse, Benjamin, additional, and Chaput, Nathalie, additional

Published
2021
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26. Interventional Radiology for Local Immunotherapy in Oncology

Author

Tselikas, Lambros, primary, Champiat, Stephane, additional, Sheth, Rahul A., additional, Yevich, Steve, additional, Ammari, Samy, additional, Deschamps, Frederic, additional, Farhane, Siham, additional, Roux, Charles, additional, Susini, Sandrine, additional, Mouraud, Severine, additional, Delpla, Alexandre, additional, Raoult, Thibault, additional, Robert, Caroline, additional, Massard, Christophe, additional, Barlesi, Fabrice, additional, Soria, Jean-Charles, additional, Marabelle, Aurélien, additional, and de Baere, Thierry, additional

Published
2021
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29. Human virome profiling identified CMV as the major viral driver of a high accumulation of senescent CD8+ T cells in patients with advanced NSCLC.

Author

Naigeon, Marie, Dugage, Matthieu Roulleaux, Danlos, François-Xavier, Boselli, Lisa, Jouniaux, Jean-Mehdi, de Oliveira, Caroline, Ferrara, Roberto, Duchemann, Boris, Berthot, Caroline, Girard, Lou, Flippot, Ronan, Albiges, Laurence, Farhane, Siham, Saulnier, Patrick, Lacroix, Ludovic, Griscelli, Frank, Roman, Gabriel, Hulett, Tyler, Marabelle, Aurélien, and Cassard, Lydie

Subjects
*IMMUNOSENESCENCE, *T cells, *NON-small-cell lung carcinoma
Abstract

Circulating senescent CD8+ T (T8sen) cells are characterized by a lack of proliferative capacities but retain cytotoxic activity and have been associated to resistance to immunotherapy in patients with advanced non-small cell lung cancer (aNSCLC). We aimed to better characterize T8sen and to determine which factors were associated with their accumulation in patients with aNSCLC. Circulating T8sen cells were characterized by a higher expression of SA-ßgal and the transcription factor T-bet, confirming their senescent status. Using whole virome profiling, cytomegalovirus (CMV) was the only virus associated with T8sen. CMV was necessary but not sufficient to explain high accumulation of T8sen (T8senhigh status). In CMV+ patients, the proportion of T8sen cells increased with cancer progression. Last, CMV-induced T8senhigh phenotype but not CMV seropositivity itself was associated with worse progression-free and overall survival in patients treated with anti-PD-(L)1 therapy but not with chemotherapy. Overall, CMV is the unique viral driver of T8sen-driven resistance to anti-PD-(L)1 antibodies in patients with aNSCLC. [ABSTRACT FROM AUTHOR]

Published
2023
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