Search

It had been demonstrated that apolipoprotein M (apoM) is an important carrier of sphingosine-1-phosphate (S1P) in blood, and the S1P has critical roles in the pathogenesis of sepsis-induced acute lung injury (ALI). In the present study, we investigated whether apoM has beneficial effects in a mouse model after lipopolysaccharide (LPS)-induced ALI. Forty-eight mice were divided into two groups: male C57BL/6 wild-type (apoM+/+) group (n = 24) and apoM gene-deficient (apoM−/−) group (n = 24) and then randomly subdivided into four subgroups (n = 6 each) according to different intraperitoneal (i.p.) injection: control group, W146 group, LPS group, and LPS + W146 group. Serum levels of interleukin-1 beta (IL-1β) and mRNA levels of IL-1β, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), lung histology, wet/dry weight ratio, and immunohistochemistry were measured at 3 h after the baseline and compared in each group. Our results clearly demonstrated that IL-1β mRNA levels and other inflammatory biomarkers were significantly increased in the lungs of LPS-induced ALI apoM−/− mice compared to those of the apoM+/+ mice. Moreover, when apoM+/+ mice were treated with W146, a S1P receptor (S1PR1) antagonist, these inflammatory biomarkers could be significantly upregulated by LPS-induced ALI. Therefore, it suggests that apoM-S1P-S1PR1 signaling might underlie the pathogenesis of ALI and apoM could have physiological benefits to alleviate LPS-induced ALI. [ABSTRACT FROM AUTHOR]

By using geo-statistics methods, an investigation was conducted on the spatial variability of soil pH, organic matter, total N, P, and K, and available N, P, K, Cu, Zn, Fe, and Mn and their relations with rice yield in Wenxing Village, Anshun City of Guizhou Province, Southwest China. The C0 / (C0 +C) ratios for the soil pH, total P, and available N, P, K, and Cu and the rice yield components were lower than 25%, indicating their strong spatial correlations, while the C0 / (C0 +C) ratios for the soil organic matter, total N and K, and available Zn, Fe, and Mn and the rice yield were 25% -75%, showing a medium spatial correlation. Of all the soil nutrients, the soil available K had the closest relation with rice yield (r =0. 4669, P<0. 0001). The direct path coefficients of the soil available N, K and P to the effective panicle and thousand-grain mass were positive, in line with the partial correlation analysis. The Kriging interpolation showed that the soil organic matter, total N, and available N, K, Cu, and Zn contents presented a decreasing trend from the southwest to northeast, but the rice yield was higher in the northwest and southeast of the Wenx-ing Village. [ABSTRACT FROM AUTHOR]

By using geo-statistics methods, an investigation was conducted on the spatial variability of soil pH, organic matter, total N, P, and K, and available N, P, K, Cu, Zn, Fe, and Mn and their relations with rice yield in Wenxing Village, Anshun City of Guizhou Province, Southwest China. The C0/(C0 + C) ratios for the soil pH, total P, and available N, P, K, and Cu and the rice yield components were lower than 25%, indicating their strong spatial correlations, while the C0/ (C0 + C) ratios for the soil organic matter, total N and K, and available Zn, Fe, and Mn and the rice yield were 25%-75%, showing a medium spatial correlation. Of all the soil nutrients, the soil available K had the closest relation with rice yield (r = 0.4669, P < 0.0001). The direct path coefficients of the soil available N, K and P to the effective panicle and thousand-grain mass were positive, in line with the partial correlation analysis. The Kriging interpolation showed that the soil organic matter, total N, and available N, K, Cu, and Zn contents presented a decreasing trend from the southwest to northeast, but the rice yield was higher in the northwest and southeast of the Wenxing Village.