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5. Recommendations for quantitative cerebral perfusion MRI using multi‐timepoint arterial spin labeling: Acquisition, quantification, and clinical applications.

Author

Woods, Joseph G., Achten, Eric, Asllani, Iris, Bolar, Divya S., Dai, Weiying, Detre, John A., Fan, Audrey P., Fernández‐Seara, María A., Golay, Xavier, Günther, Matthias, Guo, Jia, Hernandez‐Garcia, Luis, Ho, Mai‐Lan, Juttukonda, Meher R., Lu, Hanzhang, MacIntosh, Bradley J., Madhuranthakam, Ananth J., Mutsaerts, Henk‐Jan, Okell, Thomas W., and Parkes, Laura M.

Subjects
SPIN labels, PERFUSION, CLINICAL medicine, PERFUSION imaging, MAGNETIC resonance imaging
Abstract

Accurate assessment of cerebral perfusion is vital for understanding the hemodynamic processes involved in various neurological disorders and guiding clinical decision‐making. This guidelines article provides a comprehensive overview of quantitative perfusion imaging of the brain using multi‐timepoint arterial spin labeling (ASL), along with recommendations for its acquisition and quantification. A major benefit of acquiring ASL data with multiple label durations and/or post‐labeling delays (PLDs) is being able to account for the effect of variable arterial transit time (ATT) on quantitative perfusion values and additionally visualize the spatial pattern of ATT itself, providing valuable clinical insights. Although multi‐timepoint data can be acquired in the same scan time as single‐PLD data with comparable perfusion measurement precision, its acquisition and postprocessing presents challenges beyond single‐PLD ASL, impeding widespread adoption. Building upon the 2015 ASL consensus article, this work highlights the protocol distinctions specific to multi‐timepoint ASL and provides robust recommendations for acquiring high‐quality data. Additionally, we propose an extended quantification model based on the 2015 consensus model and discuss relevant postprocessing options to enhance the analysis of multi‐timepoint ASL data. Furthermore, we review the potential clinical applications where multi‐timepoint ASL is expected to offer significant benefits. This article is part of a series published by the International Society for Magnetic Resonance in Medicine (ISMRM) Perfusion Study Group, aiming to guide and inspire the advancement and utilization of ASL beyond the scope of the 2015 consensus article. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Variations in Neonatal Length of Stay of Babies Born Extremely Preterm: An International Comparison Between iNeo Networks

Author

Lui, Kei, Marshall, Peter, Schmidt, Peter, Dhawan, Anjali, Korostenski, Larissa, Travadi, Javeed Travadi, Sharp, Mary, Gill, Andy, Pillow, Jane, Stack, Jacqueline, Birch, Pita, Nothdurft, Karen, Cooke, Lucy, Casalaz, Dan, Holberton, Jim, Stewart, Alice, Downe, Lyn, Stewart, Michael, Berry, Andrew, Hunt, Rod, Morris, Peter, Paoli, Tony De, Bolisetty, Srinivas, Paradisis, Mary, Greenhalgh, Mark, Koorts, Pieter, Kuschel, Carl, Jacobs, Sue, Doyle, Lex, Craven, John, Numa, Andrew, Carlisle, Hazel, Badawi, Nadia, Popat, Himanshu, Koh, Guan, Davis, Jonathan, Luig, Melissa, Headley, Bevan, Andersen, Chad, Ng, Linda, Chambers, Georgina, Austin, Nicola, Lynn, Adrienne, Darlow, Brian, Edmonds, Liza, Mildenhall, Lindsay, Buksh, Mariam, Battin, Malcolm, Boom, Jutta van den, Richardson, Vaughan, Barker, David, Hammond, Barbara, Rajadurai, Victor Samuel, Lam, Simon, Fung, Genevieve, Shah, Prakesh S., Beltempo, Marc, Kanungo, Jaideep, Ting, Joseph, Cieslak, Zenon, Sherlock, Rebecca, Mehrem, Ayman Abou, Toye, Jennifer, Aziz, Khalid, Fajardo, Carlos, Bodani, Jaya, Strueby, Lannae, Seshia, Mary, Louis, Deepak, Alvaro, Ruben, Mukerji, Amit, Da Silva, Orlando, Adie, Mohammad, Lee, Kyong-Soon, Ng, Eugene, Lemyre, Brigitte, Daboval, Thierry, Khurshid, Faiza, Pelausa, Ermelinda, Barrington, Keith, Lapoint, Anie, Ethier, Guillaume, Drolet, Christine, Piedboeuf, Bruno, Claveau, Martine, St-Hilaire, Marie, Bertelle, Valerie, Masse, Edith, Canning, Roderick, Makary, Hala, Ojah, Cecil, Monterrosa, Luis, Emberley, Julie, Afifi, Jehier, Kajetanowicz, Andrzej, Lee, Shoo K., Metsäranta, Marjo, Lehtonen, Liisa, Tammela, Outi, Sankilampi, Ulla, Saarela, Timo, Morag, Iris, Zangen, Shmuel, Smolkin, Tatyana, Mimouni, Francis, Bader, David, Rothschild, Avi, Strauss, Zipora, Felszer, Clari, Omari, Hussam, Tov-Friedman, Smadar Even, Bar-Oz, Benjamin, Feldman, Michael, Saad, Nizar, Flidel-Rimon, Orna, Weisbrod, Meir, Lubin, Daniel, Litmanovitz, Ita, Kugelman, Amir, Shinwell, Eric, Klinger, Gil, Nijim, Yousif, Bin-Nun, Alona, Golan, Agneta, Mandel, Dror, Fleisher-Sheffer, Vered, Oron, Anat, Bakhrakh, Lev, Hattori, Satoshi, Shirai, Masaru, Ishioka, Toru, Mori, Toshihiko, Amizuka, Takasuke, Huchimukai, Toru, Yoshida, Hiroshi, Sasaki, Ayako, Shimizu, Junichi, Nakamura, Toshihiko, Maruyama, Mami, Matsumoto, Hiroshi, Hosokawa, Shinichi, Taki, Atsuko, Nakagawa, Machiko, Ko, Kyone, Uozumi, Azusa, Nakata, Setsuko, Shimazaki, Akira, Yoda, Tatsuya, Numata, Osamu, Imamura, Hiroaki, Kobayashi, Azusa, Tokuriki, Shuko, Uchida, Yasushi, Arai, Takahiro, Ito, Mitsuhiro, Ieda, Kuniko, Ono, Toshiyuki, Hayashi, Masashi, Maki, Kanemasa, Yamakawa, MieToru, Kawai, Masahiko, Fujii, Noriko, Shiomi, Kozue, Nozaki, Koji, Wada, Hiroshi, Kim, Taho, Tokunaga, Yasuyuki, Takatera, Akihiro, Oshima, Toshio, Sumida, Hiroshi, Michinomae, Yae, Kusumoto, Yoshio, Yoshimoto, Seiji, Morisawa, Takeshi, Ohashi, Tamaki, Takahashi, Yukihiro, Sugimoto, Moriharu, Ono, Noriaki, Miyagawa, Shinichiro, Saijo, Takahiko, Yamagami, Takashi, Koyano, Kosuke, Kobayashi, Shoko, Kanda, Takeshi, Sakemi, Yoshihiro, Aoki, Mikio, Iida, Koichi, Goshi, Mitsushi, Maruyama, Yuko, Avila-Alvarez, Alejandro, Fernandez-Trisac, José Luis, Pico, M<ce:sup loc='post">a</ce:sup> Luz Couce, Fernández Seara, María José, Gutiérrez, Andrés Martínez, Vizcaíno, Carolina, Iglesias, Miriam Salvador, Zaplana, Honorio Sánchez, Colomer, Belén Fernández, García López, José Enrique, Mozo, Rafael García, González Martínez, M. Teresa, Sebastián, M<ce:sup loc='post">a</ce:sup> Dolores Muro, Carbonell, Marta Balart, Barnusell, Joan Badia, Puiggròs, Mònica Domingo, Aloy, Josep Figueras, Mussons, Francesc Botet, Sanz, Israel Anquela, Galiana, Gemma Ginovart, Coroleu, W., Iriondo, Martin, Vilella, Laura Castells, Porta, Roser, Demestre, Xavier, Nadal, Silvia Martínez, de Frutos Martínez, Cristina, López Cuesta, María Jesús, Mora, Dolores Esquivel, Tardío, Joaquín Ortiz, Benavente, Isabel, Alonso, Almudena, Olmos, Ramón Aguilera, García Cabezas, Miguel A., Jiménez, M<ce:sup loc='post">a</ce:sup> Dolores Martínez, Caballero, M<ce:sup loc='post">a</ce:sup> Pilar Jaraba, Díaz, M<ce:sup loc='post">a</ce:sup> Dolores Ordoñez, Fagundo, Alberto Trujillo, Canals, Lluis Mayol, García-Muñoz Rodrigo, Fermín, Martí, Lourdes Urquía, Moreno Galdo, María Fernanda, Suazo, José Antonio Hurtado, López, Eduardo Narbona, Fernández, José Uberos, Cortajarena Altuna, Miguel A., Zuriarrain, Oihana Muga, Navarro, David Mora, Domínguez, María Teresa, Ruiz del Prado, M<ce:sup loc='post">a</ce:sup> Yolanda, Díez, Inés Esteban, Palau Benavides, María Teresa, Lapeña, Santiago, Prada, Teresa, Mir, Eduard Soler, Sánchez, Araceli Corredera, Vega, Enrique Criado, Prado, Náyade del, Fernández, Cristina, Vilaplana, Lucía Cabanillas, Pérez, Irene Cuadrado, Gómez, Luisa López, Comeche, Laura Domingo, Martín, Isabel Llana, Armengod, Carmen González, Labián, Carmen Muñoz, Muñoz, M<ce:sup loc='post">a</ce:sup> José Santos, Bravo, Dorotea Blanco, Pérez, Vicente, Fernández, M<ce:sup loc='post">a</ce:sup> Dolores Elorza, González, Celia Díaz, Segura, Susana Ares, Azorín, Manuela López, Jimenez, Ana Belén, Sánchez-Tamayo, Tomás, Moreno, Elías Tapia, González, María, Sánchez Martínez, José Enrique, Lloreda García, José María, Orayen, Concepción Goñi, González, Javier Vilas, Albo, María Suárez, Colmenero, Eva González, Gutiérrez González, Elena Pilar, Vacas del Arco, Beatriz, Fernández, Josefina Márquez, Gordillo, Laura Acosta, Asensio, Mercedes Granero, Díaz, Carmen Macías, Albújar, Mar, Jorge, Pedro Fuster, Romero, Sabina, Falero, Mónica Rivero, Escobar Izquierdo, Ana Belén, Capell, Javier Estañ, Macián, M<ce:sup loc='post">a</ce:sup> Isabel Izquierdo, Vicente, M<ce:sup loc='post">a</ce:sup> Mar Montejo, Caballero, Raquel Izquierdo, Martínez, M<ce:sup loc='post">a</ce:sup> Mercedes, Euba, Aintzane, Serna, Amaya Rodríguez, López de Heredia Goya, Juan María, Legorburu, Alberto Pérez, Amorós, Ana Gutiérrez, Marugán Isabel, Víctor Manuel, González, Natalio Hernández, Gracia, Segundo Rite, Faci, M<ce:sup loc='post">a</ce:sup> Purificación Ventura, Villagrasa, M<ce:sup loc='post">a</ce:sup> Pilar Samper, Kofron, Jiri, Brodd, Katarina Strand, Odlind, Andreas, Alberg, Lars, Arwehed, Sofia, Hafström, Ola, Kasemo, Anna, Nederman, Karin, Åhman, Lars, Ingemarsson, Fredrik, Petersson, Henrik, Thurn, Pernilla, Albinsson, Eva, Selander, Bo, Abrahamsson, Thomas, Heimdahl, Ingela, Sveinsdottir, Kristbjorg, Wejryd, Erik, Hedlund, Anna, Söderberg, Maria Katarina, Navér, Lars, Brune, Thomas, Bäckström, Jens, Robinson, Johan, Farooqi, Aijaz, Normann, Erik, Fredriksson, Magnus, Palm, Anders, Rosenqvist, Urban, Walde, Bengt, Hagman, Cecilia, Ohlin, Andreas, Florell, Rein, Smedsaas-Löfvenberg, Agneta, Adams, Mark, Meyer, Philipp, Kusche, Rachel, Schulzke, Sven, Nelle, Mathias, Wagner, Bendicht, Riedel, Thomas, Kaczala, Grégoire, Pfister, Riccardo E., Tolsa, Jean-François, Roth, Matthias, Stocker, Martin, Laubscher, Bernhard, Malzacher, Andreas, Micallef, John P., Hegi, Lukas, Bassler, Dirk, Arlettaz, Romaine, Bernet, Vera, Dani, Carlo, Fiorini, Patrizio, Ghirri, Paolo, Tomasini, Barbara, Mittal, Anita, Kefas, Jonathan, Kamalanathan, Anand, Grosdenier, Michael, Dewhurst, Christopher, Bontea, Andreea, Webb, Delyth, Garr, Ross, Hassan, Ahmed, Ambadkar, Priyadarshan, Dyke, Mark, McDevitt, Katharine, Rewitzky, Glynis, D'Amore, Angela, Kamath, P., Settle, Paul, Maddock, Natasha, Edi-Osagie, Ngozi, Zipitis, Christos, Heal, Carrie, Birch, Jacqeline, Hasib, Abdul, Soe, Aung, Abdul-Malik, Bushra, Kisat, Hamudi, Vasu, Vimal, Sivashankar, Savi, Gupta, Richa, Rawlingson, Chris, Wickham, Tim, Theron, Marice, Kendall, Giles, Gupta, Aashish, Aladangady, Narendra, Ali, Imdad, Jain, Neeraj, Mannan, Khalid, Murthy, Vadivelam, Sullivan, Caroline, Chuang, Shu-Ling, Bate, Tristan, Tyszcuzk, Lidia, Lee, Geraint, Obi, Ozioma, Chang, John, Pai, Vinay, Huddy, Charlotte, Yasin, Salim, Nicholl, Richard, Pandey, Poornima, Cusack, Jonathan, Kairamkonda, Venkatesh, Muogbo, Dominic, Harry, Liza, Surana, Pinki, Broggio, Penny, Pillay, Tilly, Deshpande, Sanjeev, Mahadevan, Moore, Alison, Bastani, Porus, Garbash, Mehdi, Lal, Mithilesh, Abu-Harb, Majd, Allwood, Alex, Selter, Michael, Munyard, Paul, Bartle, David, Paul, Siba, Whincup, Graham, Rekha, Sanghavi, Amess, Philip, Obi, Ben, Reynolds, Peter, Misra, Indranil, De Halpert, Peter, Salgia, Sanjay, Sanghavi, Rekha, Paul, Nicola, Deketelaere, Abby, Khashu, Minesh, Johnson, Mark, Groves, Charlotte, Baird, Jim, Brennan, Nick, Vamvakiti, Katia, McIntyre, John, Holman, Jennifer, Jones, Stephen, Pike, Alison, Cairns, Pamela, Eaton, Megan, Schwarz, Karin, Gibson, David, Miall, Lawrence, Krishnamurthy, Dr, Narayanan, Sankara, Seaton, Sarah E., Draper, Elizabeth S., Kusuda, Satoshi, Håkansson, Stellan, Helenius, Kjell, Reichman, Brian, Vento, Maximo, Darlow, Brian A., Rusconi, Franca, Isayama, Tetsuya, Norman, Mikael, Yang, Junmin, and Modi, Neena

Published
2021
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11. Consensus-based technical recommendations for clinical translation of renal ASL MRI

Author

Nery, Fabio, Buchanan, Charlotte E., Harteveld, Anita A., Odudu, Aghogho, Bane, Octavia, Cox, Eleanor F., Derlin, Katja, Gach, H. Michael, Golay, Xavier, Gutberlet, Marcel, Laustsen, Christoffer, Ljimani, Alexandra, Madhuranthakam, Ananth J., Pedrosa, Ivan, Prasad, Pottumarthi V., Robson, Philip M., Sharma, Kanishka, Sourbron, Steven, Taso, Manuel, Thomas, David L., Wang, Danny J. J., Zhang, Jeff L., Alsop, David C., Fain, Sean B., Francis, Susan T., and Fernández-Seara, María A.

Published
2020
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14. Clinical utility of intraoperative Arterial Spin Labeling for resection control in brain tumor surgery at 3 T

Author

Calvo‐Imirizaldu, Marta, primary, Aramendía‐Vidaurreta, Verónica, additional, Sánchez‐Albardíaz, Carmen, additional, Vidorreta, Marta, additional, de Eulate, Reyes García, additional, Domínguez Echávarri, Pablo D., additional, Pfeuffer, Josef, additional, Herruzo, Bartolomé Bejarano, additional, Gonzalez‐Quarante, Lain H., additional, Martinez‐Simon, Antonio, additional, and Fernández‐Seara, María A., additional

Published
2023
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15. Assessment of Splenic Switch‐Off With Arterial Spin Labeling in Adenosine Perfusion Cardiac MRI.

Author

Aramendía‐Vidaurreta, Verónica, Solis‐Barquero, Sergio M., Ezponda, Ana, Vidorreta, Marta, Echeverria‐Chasco, Rebeca, Pascual, Marina, Bastarrika, Gorka, and Fernández‐Seara, María A.

Subjects
SPIN labels, CARDIAC magnetic resonance imaging, ADENOSINES, PERFUSION, PEARSON correlation (Statistics)
Abstract

Background: In patients with suspected coronary artery disease (CAD), myocardial perfusion is assessed under rest and pharmacological stress to identify ischemia. Splenic switch‐off, defined as the stress to rest splenic perfusion attenuation in response to adenosine, has been proposed as an indicator of stress adequacy. Its occurrence has been previously assessed in first‐pass perfusion images, but the use of noncontrast techniques would be highly beneficial. Purpose: To explore the ability of pseudo‐continuous arterial spin labeling (PCASL) to identify splenic switch‐off in patients with suspected CAD. Study Type: Prospective. Population: Five healthy volunteers (age 24.8 ± 3.8 years) and 32 patients (age 66.4 ± 8.2 years) with suspected CAD. Field strength/Sequence: A 1.5‐T/PCASL (spin‐echo) and first‐pass imaging (gradient‐echo). Assessment: In healthy subjects, multi‐delay PCASL data (500–2000 msec) were acquired to quantify splenic blood flow (SBF) and determine the adequate postlabeling delay (PLD) for single‐delay acquisitions (PLD > arterial transit time). In patients, single‐delay PCASL (1200 msec) and first‐pass perfusion images were acquired under rest and adenosine conditions. PCASL data were used to compute SBF maps and SBF stress‐to‐rest ratios. Three observers classified patients into "switch‐off" and "failed switch‐off" groups by visually comparing rest‐stress perfusion data acquired with PCASL and first‐pass, independently. First‐pass categories were used as reference to evaluate the accuracy of quantitative classification. Statistical Tests: Wilcoxon signed‐rank, Pearson correlation, kappa, percentage agreement, Generalized Linear Mixed Model, Mann–Whitney, Pearson Chi‐squared, receiver operating characteristic, area‐under‐the‐curve (AUC) and confusion matrix. Significance: P value < 0.05. Results: A total of 27 patients (84.4%) experienced splenic switch‐off according to first‐pass categories. Comparison of PCASL‐derived SBF maps during stress and rest allowed assessment of splenic switch‐off, reflected in a reduction of SBF values during stress. SBF stress‐to‐rest ratios showed a 97% accuracy (sensitivity = 80%, specificity = 100%, AUC = 85.2%). Data Conclusion: This study could demonstrate the feasibility of PCASL to identify splenic switch‐off during adenosine perfusion MRI, both by qualitative and quantitative assessments. Evidence Level: 2 Technical Efficacy: 2 [ABSTRACT FROM AUTHOR]

Published
2023
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17. A Bilateral Whitish Lesion on the Mucosa of the Cheek

Author

Arredondo Montero, Javier, primary, Bronte Anaut, Mónica, additional, Antona, Giuseppa, additional, Peñafiel-Freire, Diego Mauricio, additional, Fernández Seara, María Pilar, additional, Ruiz de Azúa, Yerani, additional, and Guarch Troyas, Rosa, additional

Published
2022
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22. Hippocampus-Specific fMRI Group Activation Analysis with Continuous M-Reps

Author

Yushkevich, Paul A., Detre, John A., Tang, Kathy Z., Hoang, Angela, Mechanic-Hamilton, Dawn, Fernández-Seara, María A., Korczykowski, Marc, Zhang, Hui, Gee, James C., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Larsen, Rasmus, editor, Nielsen, Mads, editor, and Sporring, Jon, editor

Published
2006
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28. Corrigendum: Case Report: Two Monochorionic Twins With a Critically Different Course of Progressive Osseous Heteroplasia

Author

Justicia-Grande, Antonio José, primary, Gómez-Ríal, Jose, additional, Rivero-Calle, Irene, additional, Pischedda, Sara, additional, Curras-Tuala, María José, additional, Gómez-Carballa, Alberto, additional, Cebey-López, Miriam, additional, Pardo-Seco, Jacobo, additional, Méndez-Gallart, Roberto, additional, Fernández-Seara, María José, additional, Salas, Antonio, additional, and Martinón-Torres, Federico, additional

Published
2021
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32. Association between Circulating Levels of 25-Hydroxyvitamin D 3 and Matrix Metalloproteinase-10 (MMP-10) in Patients with Type 2 Diabetes.

Author

Abasheva, Daria, Dolcet-Negre, Marta M., Fernández-Seara, María A., Mora-Gutiérrez, José María, Orbe, Josune, Escalada, Francisco Javier, and Garcia-Fernandez, Nuria

Abstract

Background: Matrix metalloproteinase-10 (MMP-10) levels increase progressively starting from early diabetic kidney disease (DKD) stages. Vitamin D3 (vitD3) deficit is associated with a higher risk of diabetic microangiopathy. Reduced MMP-10 expression has been observed after exposure to vitD3. Aim: to assess how vitD3 status is related to MMP-10 levels in patients with Type 2 diabetes (T2D). Methods: 256 patients with T2D were included in this cross-sectional study. Demographic, clinical and serum MMP-10 and 25-hydroxyvitamin D3 (25(OH)D3) levels were collected from each patient. The association between MMP-10 and (25(OH)D3) levels was assessed using a correlation analysis and fitting a multivariate linear regression model. Results: Serum MMP-10 levels were inversely correlated with circulating 25(OH)D3 (rho = −0.25; p < 0.001). In the subgroup analysis this correlation was significant in patients with DKD (rho = −0.28; p = 0.001) and in subjects with vitD3 deficit (rho = −0.24; p = 0.005). In the regression model adjusted for kidney function, body adiposity, smoking and vitD supplementation MMP-10 levels were 68.7 pg/mL lower in patients with 25(OH)D3 > 20 ng/mL, with respect to ≤20 ng/mL (p = 0.006). Conclusions: vitD3 repletion status is an independent predictor of MMP-10 levels in T2D patients. Perhaps, high 25(OH)D3 values should be targeted in these patients in order to prevent vascular complications. [ABSTRACT FROM AUTHOR]

Published
2022
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33. Case Report: Two Monochorionic Twins With a Critically Different Course of Progressive Osseous Heteroplasia

Author

Justicia-Grande, Antonio José, primary, Gómez-Ríal, Jose, additional, Rivero-Calle, Irene, additional, Pischedda, Sara, additional, Curras-Tuala, María José, additional, Gómez-Carballa, Alberto, additional, Cebey-López, Miriam, additional, Pardo-Seco, Jacobo, additional, Méndez-Gallart, Roberto, additional, Fernández-Seara, María José, additional, Salas, Antonio, additional, and Martinón-Torres, Federico, additional

Published
2021
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39. Breath-Hold Induced Cerebrovascular Reactivity Measurements Using Optimized Pseudocontinuous Arterial Spin Labeling

Author

Solis-Barquero, Sergio M., primary, Echeverria-Chasco, Rebeca, additional, Calvo-Imirizaldu, Marta, additional, Cacho-Asenjo, Elena, additional, Martinez-Simon, Antonio, additional, Vidorreta, Marta, additional, Dominguez, Pablo D., additional, García de Eulate, Reyes, additional, Fernandez-Martinez, Miguel, additional, and Fernández-Seara, María A., additional

Published
2021
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43. Reduction of motion effects in myocardial arterial spin labeling.

Author

Aramendía‐Vidaurreta, Verónica, Gordaliza, Pedro M., Vidorreta, Marta, Echeverría‐Chasco, Rebeca, Bastarrika, Gorka, Muñoz‐Barrutia, Arrate, and Fernández‐Seara, María A.

Subjects
SPIN labels, BLOOD flow measurement, BLOOD flow, PERFUSION imaging, IMAGE registration
Abstract

Purpose: To evaluate the accuracy and reproducibility of myocardial blood flow measurements obtained under different breathing strategies and motion correction techniques with arterial spin labeling. Methods: A prospective cardiac arterial spin labeling study was performed in 12 volunteers at 3 Tesla. Perfusion images were acquired twice under breath‐hold, synchronized‐breathing, and free‐breathing. Motion detection based on the temporal intensity variation of a myocardial voxel, as well as image registration based on pairwise and groupwise approaches, were applied and evaluated in synthetic and in vivo data. A region of interest was drawn over the mean perfusion‐weighted image for quantification. Original breath‐hold datasets, analyzed with individual regions of interest for each perfusion‐weighted image, were considered as reference values. Results: Perfusion measurements in the reference breath‐hold datasets were in line with those reported in literature. In original datasets, prior to motion correction, myocardial blood flow quantification was significantly overestimated due to contamination of the myocardial perfusion with the high intensity signal of blood pool. These effects were minimized with motion detection or registration. Synthetic data showed that accuracy of the perfusion measurements was higher with the use of registration, in particular after the pairwise approach, which probed to be more robust to motion. Conclusion: Satisfactory results were obtained for the free‐breathing strategy after pairwise registration, with higher accuracy and robustness (in synthetic datasets) and higher intrasession reproducibility together with lower myocardial blood flow variability across subjects (in in vivo datasets). Breath‐hold and synchronized‐breathing after motion correction provided similar results, but these breathing strategies can be difficult to perform by patients. [ABSTRACT FROM AUTHOR]

Published
2022
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45. Brain ventricular enlargement in human and murine acute intermittent porphyria

Author

Jericó, Daniel, primary, Luis, Elkin O, additional, Cussó, Lorena, additional, Fernández-Seara, María A, additional, Morales, Xabier, additional, Córdoba, Karol M, additional, Benito, Marina, additional, Sampedro, Ana, additional, Larriva, María, additional, Ramírez, María J, additional, de Salamanca, Rafael Enríquez, additional, Ortiz-de-Solorzano, Carlos, additional, Alegre, Manuel, additional, Prieto, Jesús, additional, Lanciego, José Luis, additional, D’Avola, Delia, additional, Gonzalez-Aseguinolaza, Gloria, additional, Pastor, María A, additional, Desco, Manuel, additional, and Fontanellas, Antonio, additional

Published
2020
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48. Neonatal Outcomes in Very Preterm Infants With Severe Congenital Heart Defects: An International Cohort Study

Author

Norman, Mikael, primary, Håkansson, Stellan, additional, Kusuda, Satoshi, additional, Vento, Maximo, additional, Lehtonen, Liisa, additional, Reichman, Brian, additional, Darlow, Brian A., additional, Adams, Mark, additional, Bassler, Dirk, additional, Isayama, Tetsuya, additional, Rusconi, Franca, additional, Lee, Shoo, additional, Lui, Kei, additional, Yang, Junmin, additional, Shah, Prakesh S., additional, Marshall, Peter, additional, Schmidt, Peter, additional, Dhawan, Anjali, additional, Craven, Paul, additional, de Waal, Koert, additional, Simmer, Karen, additional, Gill, Andy, additional, Pillow, Jane, additional, Stack, Jacqueline, additional, Birch, Pita, additional, Cooke, Lucy, additional, Casalaz, Dan, additional, Holberton, Jim, additional, Stewart, Alice, additional, Downe, Lyn, additional, Stewart, Michael, additional, Bajuk, Barbara, additional, Berry, Andrew, additional, Hunt, Rod, additional, Kilburn, Charles, additional, De Paoli, Tony, additional, Bolisetty, Srinivas, additional, Paradisis, Mary, additional, Rieger, Ingrid, additional, Koorts, Pieter, additional, Kuschel, Carl, additional, Doyle, Lex, additional, Numa, Andrew, additional, Carlisle, Hazel, additional, Badawi, Nadia, additional, Loughran‐Fowlds, Alison, additional, Koh, Guan, additional, Davis, Jonathan, additional, Luig, Melissa, additional, Andersen, Chad, additional, Chambers, Georgina, additional, Austin, Nicola, additional, Lynn, Adrienne, additional, Darlow, Brian, additional, Edmonds, Liza, additional, Mildenhall, Lindsay, additional, Buksh, Mariam, additional, Battin, Malcolm, additional, van den Boom, Jutta, additional, Bourchier, David, additional, Richardson, Vaughan, additional, Dineen, Fiona, additional, Rajadurai, Victor Samuel, additional, Lam, Simon, additional, Fung, Genevieve, additional, Harrison, Adele, additional, Synnes, Anne, additional, Ting, Joseph, additional, Cieslak, Zenon, additional, Sherlock, Rebecca, additional, Yee, Wendy, additional, Aziz, Khalid, additional, Toye, Jennifer, additional, Fajardo, Carlos, additional, Kalapesi, Zarin, additional, Sankaran, Koravangattu, additional, Daspal, Sibasis, additional, Seshia, Mary, additional, Alvaro, Ruben, additional, Mukerji, Amit, additional, Da Silva, Orlando, additional, Nwaesei, Chuks, additional, Lee, Kyong‐Soon, additional, Dunn, Michael, additional, Lemyre, Brigitte, additional, Dow, Kimberly, additional, Pelausa, Ermelinda, additional, Barrington, Keith, additional, Drolet, Christine, additional, Piedboeuf, Bruno, additional, Claveau, Martine, additional, Beltempo, Marc, additional, Bertelle, Valerie, additional, Masse, Edith, additional, Canning, Roderick, additional, Makary, Hala, additional, Ojah, Cecil, additional, Monterrosa, Luis, additional, Deshpandey, Akhil, additional, Afifi, Jehier, additional, Kajetanowicz, Andrzej, additional, Lee, Shoo K., additional, Andersson, Sture, additional, Tammela, Outi, additional, Sankilampi, Ulla, additional, Saarela, Timo, additional, Heymann, Eli, additional, Zangen, Shmuel, additional, Smolkin, Tatyana, additional, Mimouni, Francis, additional, Bader, David, additional, Rothschild, Avi, additional, Strauss, Zipora, additional, Felszer, Clari, additional, Omari, Hussam, additional, Tov‐Friedman, Smadar Even, additional, Bar‐Oz, Benjamin, additional, Feldman, Michael, additional, Saad, Nizar, additional, Flidel‐Rimon, Orna, additional, Weisbrod, Meir, additional, Lubin, Daniel, additional, Litmanovitz, Ita, additional, Kugelman, Amir, additional, Shinwell, Eric, additional, Klinger, Gil, additional, Nijim, Yousif, additional, Bin‐Nun, Alona, additional, Golan, Agneta, additional, Mandel, Dror, additional, Fleisher‐Sheffer, Vered, additional, Kohelet, David, additional, Bakhrakh, Lev, additional, Hattori, Satoshi, additional, Shirai, Masaru, additional, Ishioka, Toru, additional, Mori, Toshihiko, additional, Amizuka, Takasuke, additional, Huchimukai, Toru, additional, Yoshida, Hiroshi, additional, Sasaki, Ayako, additional, Shimizu, Junichi, additional, Nakamura, Toshihiko, additional, Maruyama, Mami, additional, Matsumoto, Hiroshi, additional, Hosokawa, Shinichi, additional, Taki, Atsuko, additional, Nakagawa, Machiko, additional, Ko, Kyone, additional, Uozumi, Azusa, additional, Nakata, Setsuko, additional, Shimazaki, Akira, additional, Yoda, Tatsuya, additional, Numata, Osamu, additional, Imamura, Hiroaki, additional, Kobayashi, Azusa, additional, Tokuriki, Shuko, additional, Uchida, Yasushi, additional, Arai, Takahiro, additional, Ito, Mitsuhiro, additional, Ieda, Kuniko, additional, Ono, Toshiyuki, additional, Hayashi, Masashi, additional, Maki, Kanemasa, additional, Yamakawa, MieToru, additional, Kawai, Masahiko, additional, Fujii, Noriko, additional, Shiomi, Kozue, additional, Nozaki, Koji, additional, Wada, Hiroshi, additional, Kim, Taho, additional, Tokunaga, Yasuyuki, additional, Takatera, Akihiro, additional, Oshima, Toshio, additional, Sumida, Hiroshi, additional, Michinomae, Yae, additional, Kusumoto, Yoshio, additional, Yoshimoto, Seiji, additional, Morisawa, Takeshi, additional, Ohashi, Tamaki, additional, Takahashi, Yukihiro, additional, Sugimoto, Moriharu, additional, Ono, Noriaki, additional, Miyagawa, Shinichiro, additional, Saijo, Takahiko, additional, Yamagami, Takashi, additional, Koyano, Kosuke, additional, Kobayashi, Shoko, additional, Kanda, Takeshi, additional, Sakemi, Yoshihiro, additional, Aoki, Mikio, additional, Iida, Koichi, additional, Goshi, Mitsushi, additional, Maruyama, Yuko, additional, Avila‐Alvarez, Alejandro, additional, Fernandez‐Trisac, José Luis, additional, Pico, Mª Luz Couce, additional, Fernández Seara, María José, additional, Gutiérrez, Andrés Martínez, additional, Vizcaíno, Carolina, additional, Salvador Iglesias, Miriam, additional, Zaplana, Honorio Sánchez, additional, Fernández Colomer, Belén, additional, García López, José Enrique, additional, Mozo, Rafael García, additional, Martínez, M. Teresa González, additional, Muro Sebastián, Mª Dolores, additional, Carbonell, Marta Balart, additional, Barnusell, Joan Badia, additional, Puiggròs, Mònica Domingo, additional, Taulí, Corporacio Parc, additional, Aloy, Josep Figueras, additional, Mussons, Francesc Botet, additional, Sanz, Israel Anquela, additional, Galiana, Gemma Ginovart, additional, De La Santa, H., additional, Coroleu, W., additional, Iriondo, Martin, additional, Castells Vilella, Laura, additional, Porta, Roser, additional, Demestre, Xavier, additional, Martínez Nadal, Silvia, additional, de Frutos Martínez, Cristina, additional, López Cuesta, María Jesús, additional, Mora, Dolores Esquivel, additional, Tardío, Joaquín Ortiz, additional, Benavente, Isabel, additional, Alonso, Almudena, additional, Aguilera Olmos, Ramón, additional, García Cabezas, Miguel A., additional, Martínez Jiménez, Mª Dolores, additional, Jaraba Caballero, Mª Pilar, additional, Ordoñez Díaz, Mª Dolores, additional, Fagundo, Alberto Trujillo, additional, Canals, Lluis Mayol, additional, Rodrigo, Fermín García‐Muñoz, additional, Martí, Lourdes Urquía, additional, Galdo, María Fernanda Moreno, additional, Suazo, José Antonio Hurtado, additional, López, Eduardo Narbona, additional, Fernández, José Uberos, additional, Cortajarena Altuna, Miguel A., additional, Muga Zuriarrain, Oihana, additional, Mora Navarro, David, additional, Domínguez, María Teresa, additional, del Prado, Mª Yolanda Ruiz, additional, Díez, Inés Esteban, additional, Palau Benavides, María Teresa, additional, Lapeña, Santiago, additional, Prada, Teresa, additional, Mir, Eduard Soler, additional, Sánchez, Araceli Corredera, additional, Vega, Enrique Criado, additional, del Prado, Náyade, additional, Fernández, Cristina, additional, Vilaplana, Lucía Cabanillas, additional, Pérez, Irene Cuadrado, additional, Gómez, Luisa López, additional, Comeche, Laura Domingo, additional, Martín, Isabel Llana, additional, González Armengod, Carmen, additional, Labián, Carmen Muñoz, additional, Santos Muñoz, Mª José, additional, Bravo, Dorotea Blanco, additional, Pérez, Vicente, additional, Fernández, Mª Dolores Elorza, additional, González, Celia Díaz, additional, Segura, Susana Ares, additional, Azorín, Manuela López, additional, MD, Ana Belén Jimenez, additional, Sánchez‐Tamayo, Tomás, additional, Moreno, Elías Tapia, additional, González, María, additional, Sánchez Martínez, José Enrique, additional, Lloreda García, José María, additional, Orayen, Concepción Goñi, additional, González, Javier Vilas, additional, Albo, María Suárez, additional, Colmenero, Eva González, additional, Gutiérrez González, Elena Pilar, additional, Vacas del Arco, Beatriz, additional, Fernández, Josefina Márquez, additional, Gordillo, Laura Acosta, additional, Asensio, Mercedes Granero, additional, Díaz, Carmen Macías, additional, Albújar, Mar, additional, Fuster Jorge, Pedro, additional, Romero, Sabina, additional, Falero, Mónica Rivero, additional, Escobar Izquierdo, Ana Belén, additional, Estañ Capell, Javier, additional, Izquierdo Macián, Mª Isabel, additional, Montejo Vicente, Mª Mar, additional, Caballero, Raquel Izquierdo, additional, Martínez, Mª Mercedes, additional, Euba, Aintzane, additional, Serna, Amaya Rodríguez, additional, de Heredia Goya, Juan María López, additional, Legorburu, Alberto Pérez, additional, Amorós, Ana Gutiérrez, additional, Isabel, Víctor Manuel Marugán, additional, González, Natalio Hernández, additional, Gracia, Segundo Rite, additional, Faci, Mª Purificación Ventura, additional, Villagrasa, Mª Pilar Samper, additional, Kofron, Jiri, additional, Strand Brodd, Katarina, additional, Odlind, Andreas, additional, Alberg, Lars, additional, Arwehed, Sofia, additional, Hafström, Ola, additional, Kasemo, Anna, additional, Nederman, Karin, additional, Åhman, Lars, additional, Ingemarsson, Fredrik, additional, Petersson, Henrik, additional, Thurn, Pernilla, additional, Albinsson, Eva, additional, Selander, Bo, additional, Abrahamsson, Thomas, additional, Heimdahl, Ingela, additional, Sveinsdottir, Kristbjorg, additional, Wejryd, Erik, additional, Hedlund, Anna, additional, Söderberg, Maria Katarina, additional, Navér, Lars, additional, Brune, Thomas, additional, Bäckström, Jens, additional, Robinson, Johan, additional, Farooqi, Aijaz, additional, Normann, Erik, additional, Fredriksson, Magnus, additional, Palm, Anders, additional, Rosenqvist, Urban, additional, Walde, Bengt, additional, Hagman, Cecilia, additional, Ohlin, Andreas, additional, Florell, Rein, additional, Smedsaas‐Löfvenberg, Agneta, additional, Meyer, Philipp, additional, Kusche, Rachel, additional, Schulzke, Sven, additional, Nelle, Mathias, additional, Wagner, Bendicht, additional, Riedel, Thomas, additional, Kaczala, Grégoire, additional, Pfister, Riccardo E., additional, Tolsa, Jean‐François, additional, Roth, Matthias, additional, Stocker, Martin, additional, Laubscher, Bernhard, additional, Malzacher, Andreas, additional, Micallef, John P., additional, Hegi, Lukas, additional, Arlettaz, Romaine, additional, Bernet, Vera, additional, Dani, Carlo, additional, Fiorini, Patrizio, additional, Ghirri, Paolo, additional, and Tomasini, Barbara, additional

Published
2020
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49. Consensus-based technical recommendations for clinical translation of renal ASL MRI

Author

Nery, Fabio, primary, Buchanan, Charlotte E., additional, Harteveld, Anita A., additional, Odudu, Aghogho, additional, Bane, Octavia, additional, Cox, Eleanor F., additional, Derlin, Katja, additional, Gach, H. Michael, additional, Golay, Xavier, additional, Gutberlet, Marcel, additional, Laustsen, Christoffer, additional, Ljimani, Alexandra, additional, Madhuranthakam, Ananth J., additional, Pedrosa, Ivan, additional, Prasad, Pottumarthi V., additional, Robson, Philip M., additional, Sharma, Kanishka, additional, Sourbron, Steven, additional, Taso, Manuel, additional, Thomas, David L., additional, Wang, Danny J. J., additional, Zhang, Jeff L., additional, Alsop, David C., additional, Fain, Sean B., additional, Francis, Susan T., additional, and Fernández-Seara, María A., additional

Published
2019
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