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280 results on '"Fiorentini, S"'

11. Stellar evolution and large extra dimensions

Author

Cassisi, S., Castellani, V., Fiorentini, S. Degl'Innocenti G., and Ricci, B.

Subjects
Astrophysics, High Energy Physics - Phenomenology
Abstract

We discuss in detail the information on large extra dimensions which can be derived in the framework of stellar evolution theory and observation. The main effect of large extra dimensions arises from the production of the Kaluza-Klein (KK) excitations of the graviton. The KK-graviton and matter interactions are of gravitational strength, so the KK states never become thermalized and always freely escape. In this paper we first pay attention to the sun. Production of KK gravitons is incompatible with helioseismic constraints unless the 4+n dimensional Planck mass M_s exceeds 300 Gev/c^2. Next we show that stellar structures in their advanced phase of H burning evolution put much more severe constraints, M_s > 3-4 TeV/c^2, improving on current laboratory lower limits., Comment: 13 pages RevTeX file, 8 figures ps files

Published
2000
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13. Impact of wildfire on the edaphic microarthropod community in a Pinus pinaster forest in central Italy

Author

Lisa C, Paffetti D, Nocentini S, Marchi E, Bottalico F, Fiorentini S, and Travaglini D

Subjects
Biomonitoring, Microarthropod Community, Forest Fires, Pinus pinaster Aiton, Forestry, SD1-669.5
Abstract

The purpose of this study was to investigate the response of the soil microarthropod community to wildfire in forest ecosystems. The edaphic microarthropod communities of pine stands burned in 2001, in 2009, both in 2001 and in 2009, in 2012 were compared to an area never burned. Sampling was conducted in the spring and autumn of 2011 and 2012 in the areas burned in 2001, in 2009 and those never burned, while in the area burned in 2012, soil samples were collected in March (10 days after fire), June and September. The abundance and biodiversity of the microarthropod community were assessed. A multitemporal analysis was also carried out to assess the effect of fire on soil microarthropod abundance 5 months, 2-3 years and 10-11 years after fire. The results showed that the abundance of edaphic microarthropod communities decreased dramatically in areas burned twice, but also in areas burned once in 2009 and five months after the fire in the area burned in 2012. Different taxonomic groups did not seem to respond to fire in the same way, some taxa being more sensitive than others. Pseudoscorpionida decreased in both the short- and the long-term, while Diplopoda, Thysanoptera and Symphyla showed a reduction in the intermediate- and long-term. In the short-term, Diptera and Coleoptera larvae appeared to be the most influenced taxonomic groups. Our study shows that biomonitoring is a valuable tool to investigate the reaction of forest ecosystems to fire, and that edaphic microarthropods can provide interesting answers about the direct and indirect effects of fire on soil.

Published
2015
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15. Stand dynamics and natural regeneration in silver fir (Abies alba Mill.) plantations after traditional rotation age

Author

Bottalico F, Travaglini D, Fiorentini S, Lisa C, and Nocentini S

Subjects
Abies alba Mill., Plantations, Gap Dynamics, Natural Regeneration, Forest Biodiversity, Forestry, SD1-669.5
Abstract

In the Apennine mountains most pure silver fir stands originated from planting and were managed according to the traditional model, with clear cutting and a 100 year rotation. In the last decades in most of these stands there has been a change towards nature conservation and active management has stopped. The aim of this work was (1) to analyse stand dynamics and spontaneous regeneration processes that are taking place with increasing age in even aged fir plantations, and (2) to discuss if these processes can be useful for defining management approaches answering biodiversity conservation aims. The study was carried out in the Vallombrosa Forest (Central Italy). The relationship between fir stand age and structural parameters was analyzed using inventory data. Gap dynamics were monitored between 1983 and 2007 on the basis of remote sensing data. Based on a field survey of a sample of gaps, species composition and density of seedlings and saplings were analysed in relation to gap size and within-gap position. From 1983 to 2007 the number of gaps and their total area increased, following increasing stand age. Significant relationships (p < 0.01) were found between fir stand age and number of trees per hectare (r = -0.30), quadratic mean diameter (r = 0.65) and volume per hectare (r = 0.50). In the fir stands with lower stand density, a layer of trees with DBH < 15 cm had filled in the structure: fifteen different broadleaf species were recorded in this layer, usually mixed with fir. Gap size had an influence on presence of young firs (seedlings and fir < 0.5 m), which were significantly more numerous in gaps < 200 m2, but it had relatively limited influence on species diversity. Within-gap position did not influence regeneration density. Results indicate that a possible management option for gradually transforming even aged fir plantations in the Apennines into mixed, naturally regenerating systems, could be based on the creation of small gaps (< 200 m2) in the canopy cover, simulating the natural dynamics that are taking place in ageing fir plantations.

Published
2014
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16. Spin Transfer Torques in Ultra-Scaled MRAM Cells

Author

Bendra, M., primary, Fiorentini, S., additional, Ender, J., additional, de Orio, R. L., additional, Hadamek, T., additional, Loch, W. J., additional, Jorstad, N. P., additional, Selberherr, S., additional, Goes, W., additional, and Sverdlov, V., additional

Published
2022
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23. Micromagnetic modeling of double spin-torque magnetic tunnel junction devices.

Author

Pruckner, B., Fiorentini, S., Goes, W., Selberherr, S., and Sverdlov, V.

Subjects
*MAGNETIC tunnelling, *NONVOLATILE random-access memory, *TUNNEL junctions (Materials science), *SPIN valves, *MAGNETIC torque, *FLASH memory, *TORQUE
Abstract

Emerging nonvolatile magnetoresistive random access memory exhibits high endurance and long data retention compared to flash memory. Additionally, devices with double spin torque magnetic tunnel junctions (dsMTJ) featuring two magnetic reference layers demonstrate enhanced torques, fast switching, and reduced switching currents. To accurately model these devices, we adopt a coupled spin and charge transport approach allowing to describe spin-transfer torques in metallic spin valves and magnetic tunnel junctions on equal footing. Our findings indicate the critical influence of metallic non-magnetic spacers (NMS) properties separating the free layer from the second reference layer on the switching speed improvement in dsMTJ devices. • Coupled charge, spin and magnetization dynamics. • Spin torques in novel STT-MRAM sturcture, double spin-torque MTJ (dsMTJ). • Additional torque in dsMTJ due to second RL. • Two times faster switching compard to regular MTJs. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Lymphomagenic properties of a HIV p17 variant derived from a splenic marginal zone lymphoma occurred in a HIV-infected patient

Author

Caccuri, F, Muraro, E, Gloghini, A, Turriziani, O, Riminucci, M, Giagulli, C, Mastorci, K, Fae, DA, Fiorentini, S, Caruso, A, Carbone, A, Dolcetti, R, Caccuri, F, Muraro, E, Gloghini, A, Turriziani, O, Riminucci, M, Giagulli, C, Mastorci, K, Fae, DA, Fiorentini, S, Caruso, A, Carbone, A, and Dolcetti, R

Abstract

Despite antiretroviral therapy, HIV+ individuals still have increased risk to develop lymphomas, including marginal zone lymphomas, suggesting that factors other than HIV-related immunosuppression are probably acting as lymphomagenic factors in the HIV setting. The possible pathogenic involvement of HIV p17 protein variants was investigated in a particularly informative case of HIV-related splenic marginal zone lymphoma, which was negative for oncogenic virus infections, thus allowing us to assess the possible direct contribution of these HIV-encoded proteins to lymphomagenesis. The presence of p17 protein was analyzed by immunohistochemistry in lymphoma tissue. Recombinant p17 protein derived from the dominant sequence detected in plasma and lymphoma biopsy was characterized for B-cell proliferation, clonogenicity in soft agar, in vitro tube formation and wound healing. Intracellular signaling was investigated by immunoblotting. HIV p17 protein was detected in reactive lymphoid follicles but not within lymphoma cells. An identical dominant variant p17 sequence, p17-Lyrm, carrying a 117 to 118 Ala-Ala insertion was detected in both plasma and lymphoma tissue. Recombinant p17-Lyrm enhanced B-cell proliferation and clonogenicity promoted the formation of capillary-like structures and enhanced endothelial cell migration. Unlike reference p17, the p17-Lyrm variant enhanced the activation of Akt and ERK, critical kinases in lymphomagenesis. p17-Lyrm clonogenic activity was dependent on the activation of Akt but not of ERK1/2. These results indicated that HIV p17 variants with distinct molecular signatures and functional properties may accumulate in lymphoid tissues of HIV-infected individuals where they may act as a local stimulus promoting the development of lymphomas.

Published
2019

33. A single amino acid substitution confers B-cell clonogenic activity to the HIV-1 matrix protein p17

Author

Giagulli, C, D'Ursi, P, He, W, Zorzan, S, Caccuri, F, Varney, K, Orro, A, Marsico, S, Otjacques, B, Laudanna, C, Milanesi, L, Dolcetti, R, Fiorentini, S, Lu, W, Caruso, A, Giagulli, C, D'Ursi, P, He, W, Zorzan, S, Caccuri, F, Varney, K, Orro, A, Marsico, S, Otjacques, B, Laudanna, C, Milanesi, L, Dolcetti, R, Fiorentini, S, Lu, W, and Caruso, A

Abstract

Recent data highlight the presence, in HIV-1-seropositive patients with lymphoma, of p17 variants (vp17s) endowed with B-cell clonogenicity, suggesting a role of vp17s in lymphomagenesis. We investigated the mechanisms responsible for the functional disparity on B cells between a wild-type p17 (refp17) and a vp17 named S75X. Here, we show that a single Arginine (R) to Glycine (G) mutation at position 76 in the refp17 backbone (p17R76G), as in the S75X variant, is per se sufficient to confer a B-cell clonogenic potential to the viral protein and modulate, through activation of the PTEN/PI3K/Akt signaling pathway, different molecules involved in apoptosis inhibition (CASP-9, CASP-7, DFF-45, NPM, YWHAZ, Src, PAX2, MAPK8), cell cycle promotion and cancer progression (CDK1, CDK2, CDK8, CHEK1, CHEK2, GSK-3 beta, NPM, PAK1, PP2C-alpha). Moreover, the only R to G mutation at position 76 was found to strongly impact on protein folding and oligomerization by altering the hydrogen bond network. This generates a conformational shift in the p17 R76G mutant which enables a functional epitope(s), masked in refp17, to elicit B-cell growth-promoting signals after its interaction with a still unknown receptor(s). Our findings offer new opportunities to understand the molecular mechanisms accounting for the B-cell growth-promoting activity of vp17s.

Published
2017

35. Multicenter Evaluation of Anyplex Plus MTB/NTM MDR-TB Assay for Rapid Detection of Mycobacterium tuberculosis Complex and Multidrug-Resistant Isolates in Pulmonary and Extrapulmonary Specimens

Author

Sali, Michela, De Maio, Flavio, Caccuri, F, Campilongo, F, Sanguinetti, Maurizio, Fiorentini, S, Delogu, Giovanni, Giagulli, C., Sali, Michela (ORCID:0000-0003-3609-2990), Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), Delogu, Giovanni (ORCID:0000-0003-0182-8267), Sali, Michela, De Maio, Flavio, Caccuri, F, Campilongo, F, Sanguinetti, Maurizio, Fiorentini, S, Delogu, Giovanni, Giagulli, C., Sali, Michela (ORCID:0000-0003-3609-2990), Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), and Delogu, Giovanni (ORCID:0000-0003-0182-8267)

Abstract

The rapid diagnosis of tuberculosis (TB) and the detection of drug-resistant Mycobacterium tuberculosis strains are critical for successful public health interventions. Therefore, TB diagnosis requires the availability of diagnostic tools that allow the rapid detection of M. tuberculosis and drug resistance in clinical samples. Here, we performed a multicenter study to evaluate the performance of the Seegene Anyplex MTB/NTM MDR-TB assay, a new molecular method based on a multiplex real-time PCR system, for detection of Mycobacterium tuberculosis complex (MTBC), nontuberculous mycobacteria (NTM), and genetic determinants of drug resistance. In total, the results for 755 samples (534 pulmonary and 221 extrapulmonary samples) were compared with the results of smears and cultures. For pulmonary specimens, the sensitivities of the Anyplex assay and acid-fast bacillus smear testing were 86.4% and 75.0%, respectively, and the specificities were 99% and 99.4%. For extrapulmonary specimens, the sensitivities of the Anyplex assay and acid-fast bacillus smear testing were 83.3% and 50.0%, respectively, and the specificities of both were 100%. The negative and positive predictive values of the Anyplex assay for pulmonary specimens were 97% and 100%, respectively, and those for extrapulmonary specimens were 84.6% and 100%. The sensitivities of the Anyplex assay for detecting isoniazid resistance in MTBC strains from pulmonary and extrapulmonary specimens were 83.3% and 50%, respectively, while the specificities were 100% for both specimen types. These results demonstrate that the Anyplex MTB/NTM MDR-TB assay is an efficient and rapid method for the diagnosis of pulmonary and extrapulmonary TB and the detection of isoniazid resistance.

Published
2016

37. Phenotypic and functional characteristics of tumour-derived microvascular endothelial cells

Author

Alessandri, G, Chirivi, R, Fiorentini, S, Dossi, R, Bonardelli, S, Giulini, S, Zanetta, G, Landoni, F, Graziotti, P, Turano, A, Caruso, A, Zardi, L, Giavazzi, R, Bani, M, Alessandri G., Chirivi R. G. S., Fiorentini S., Dossi R., Bonardelli S., Giulini S. M., Zanetta G., Landoni F., Graziotti P. P., Turano A., Caruso A., Zardi L., Giavazzi R., Bani M. R., Alessandri, G, Chirivi, R, Fiorentini, S, Dossi, R, Bonardelli, S, Giulini, S, Zanetta, G, Landoni, F, Graziotti, P, Turano, A, Caruso, A, Zardi, L, Giavazzi, R, Bani, M, Alessandri G., Chirivi R. G. S., Fiorentini S., Dossi R., Bonardelli S., Giulini S. M., Zanetta G., Landoni F., Graziotti P. P., Turano A., Caruso A., Zardi L., Giavazzi R., and Bani M. R.

Abstract

We recently developed a method for the isolation and purification of tumour-derived endothelium. In this study the phenotypic and functional properties of human tumour-derived microvascular endothelial cells (TdMEC) were examined. Endothelium obtained from human adrenal gland specimens (HAMEC) was used as a reference microvascular endothelial cell population. TdMEC formed a confluent monolayer with the typical morphological appearance of endothelium and were positive for endothelial markers such as Ulex-1 lectin, CD31 antigen, von Willebrand Factor and VE-cadherin. The addition of acidic Fibroblast Growth Factor (aFGF), basic FGF (bFGF) or Vascular Endothelial Growth Factor (VEGF) substantially improved proliferation of TdMEC; and kidney carcinoma derived endothelial cells were more responsive to FGFs, whereas glioblastoma derived endothelial cells greatly responded to VEGF. TdMEC expressed high levels of the VEGF receptors, KDR/flk-1 and Flt-1, as shown by northern blot analysis. TdMEC expressed the adhesion molecules ICAM-1, VCAM-1 and E-selectin that could be further increased by exposing TdMEC culture to interleukin-1. All the TdMEC expressed interleukin-8 mRNA. These findings show that TdMEC in vitro maintain several of the features described for microvasculature. Thus, TdMEC represent a useful tool to study markers for tumor vasculature

Published
1999

39. Molecular interaction studies of HIV-1 matrix protein p17 and heparin: identification of the heparin-binding motif of p17 as a target for the development of multitarget antagonists

Author

Bugatti A, Giagulli C, Urbinati C, Caccuri F, Chiodelli P, Oreste P, Fiorentini S, Orro A, Milanesi L, D'Ursi P, Caruso A, and Rusnati M.

Subjects
immune system diseases, viruses, virus diseases
Abstract

Background: HIV-1 p17 binds heparin and heparan sulfate proteoglycans of the cell surface. Results: Heparin/p17interactionoccursthroughheparinsulfategroupsandalinearbasicmotifofp17Nterminus,alsoinvolved in p17/CXCR1 interaction. Conclusion: Targeting the basic motif inhibits p17-receptors interaction and consequent biological activities. Significance: Heparin-like molecules represent template for the development of new treatments of p17-dependent/AIDS- associated pathologies.

Published
2013
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43. Cognitive experience of oral cancer among young people of 'Sapienza' University of Rome

Author

Ottolenghi, Livia, Romeo, Umberto, Carpenteri, F., Fiorentini, S., Boatta, D., Vestri, Anna Rita, Barbato, Ersilia, and Polimeni, Antonella

Subjects
Original Article
Abstract

the aim of this study was to analyse the awareness of oral cancer among young adults in the city of Rome.during the orientation period for new graduates students, or "Porte aperte", organised by the Sapienza University of Rome in July 2009 and 2010, a survey among young people regarding their knowledge on the risk factors, the importance of early diagnosis, and the methods for primary and secondary prevention of oral cancer was conducted. A total of 1125 questionnaires were administered to subjects who agreed to respond to assess the level of knowledge of the disease.only 45.3% of the sample population was aware of the existence of oral cancer; among these individuals, 36.9% did not perceive seriousness of the malignancy. High school students who attended a scientific high school knew the risk factors better than the students who attended classical and technical high school.rigorous educational programs along with diagnostic strategies promise to reduce the burden of oral cancer. The data obtained from this study highlight the need to increase health education, especially among young people in humanistic or technical high schools and universities (Classical High School, Technical Institutes, Faculty of Letters, Faculty of Law) where there is a lack of knowledge concerning oral cancer prevention.

Published
2012

46. Phenotypic and functional characteristics of tumour-derived microvascular endothelial cells

Author

Alessandri G., Chirivi R. G. S., Fiorentini S., Dossi R., Bonardelli S., Giulini S. M., Zanetta G., Landoni F., Graziotti P. P., Turano A., Caruso A., Zardi L., Giavazzi R., Bani M. R., Alessandri, G, Chirivi, R, Fiorentini, S, Dossi, R, Bonardelli, S, Giulini, S, Zanetta, G, Landoni, F, Graziotti, P, Turano, A, Caruso, A, Zardi, L, Giavazzi, R, and Bani, M

Subjects
Vascular Endothelial Growth Factor A, Adhesion molecule, Mitogen, Endothelial Growth Factors, Endothelial Growth Factor, Antigens, CD, Lectins, Neoplasms, Proto-Oncogene Proteins, Tumour microvessel, von Willebrand Factor, Tumor Cells, Cultured, Humans, Receptors, Growth Factor, Endothelium, Cytokine, Platelet-Derived Growth Factor, Proto-Oncogene Protein, Lymphokines, Vascular Endothelial Growth Factor Receptor-1, Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor, Microcirculation, Interleukin-8, Receptor Protein-Tyrosine Kinases, Cadherins, VEGF, Receptor Protein-Tyrosine Kinase, Platelet Endothelial Cell Adhesion Molecule-1, Phenotype, Receptors, Vascular Endothelial Growth Factor, Cell Adhesion Molecule, Cadherin, Lymphokine, Neoplasm, Fibroblast Growth Factor 1, Fibroblast Growth Factor 2, Endothelium, Vascular, Mitogens, Plant Lectins, Lectin, Cell Adhesion Molecules, Cell Division, Human
Abstract

We recently developed a method for the isolation and purification of tumour-derived endothelium. In this study the phenotypic and functional properties of human tumour-derived microvascular endothelial cells (TdMEC) were examined. Endothelium obtained from human adrenal gland specimens (HAMEC) was used as a reference microvascular endothelial cell population. TdMEC formed a confluent monolayer with the typical morphological appearance of endothelium and were positive for endothelial markers such as Ulex-1 lectin, CD31 antigen, von Willebrand Factor and VE-cadherin. The addition of acidic Fibroblast Growth Factor (aFGF), basic FGF (bFGF) or Vascular Endothelial Growth Factor (VEGF) substantially improved proliferation of TdMEC; and kidney carcinoma derived endothelial cells were more responsive to FGFs, whereas glioblastoma derived endothelial cells greatly responded to VEGF. TdMEC expressed high levels of the VEGF receptors, KDR/flk-1 and Flt-1, as shown by northern blot analysis. TdMEC expressed the adhesion molecules ICAM-1, VCAM-1 and E-selectin that could be further increased by exposing TdMEC culture to interleukin-1. All the TdMEC expressed interleukin-8 mRNA. These findings show that TdMEC in vitro maintain several of the features described for microvasculature. Thus, TdMEC represent a useful tool to study markers for tumor vasculature

Published
2000

47. Valutazione dell'impatto di possibili coltivazioni di pioppo transgenico in aree protette

Author

Buonamici, A., Paffetti, D., Travaglini, D., Biricolti, S., Bottalico, F., Chelazzi, L., Cimò, F., Colombini, I, Fiorentini, S., Tomaselli, V., Fasano, G., Materassi, A., and Vettori, C.

Subjects
Biodiversità, Populus, Piante Transgeniche, ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS, Flusso Genico, InformationSystems_MISCELLANEOUS, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Populus, Biodiversità, Piante Transgeniche, Flusso Genico
Abstract

Il Parco Regionale di Migliarino-San Rossore-Massaciuccoli in Toscana è stato scelto come sito di studio nell'ambito del progetto europeo LIFE08 NAT/IT/342. Questo progetto è volto allo sviluppo di un indice di monitoraggio rapido (quick monitoring index, QMI) per valutare il rischio potenziale generato da piante transgeniche sugli ecosistemi agroforestali. Per questo scopo sono state selezionate tre aree di studio per determinarne la biodiversità vegetale, animale e dei microrganismi del suolo. Sono state prese particolarmente in considerazione aree vicine a superfici agricole dove potrebbero essere coltivate piante geneticamente modificate (PGM). Per ridurre il rischio di inquinamento genico di aree naturali da parte di polline di PGM, è utile sviluppare un sistema di monitoraggio efficiente che tenga conto della diversità genetica e di possibili incroci tra specie affini. Per quando riguarda la biodiversità arborea, nelle aree di studio sono state studiate specie del genere Populus. Le aree di studio selezionate per il pioppo distano tra loro 8 Km: l'area A è situata nella Tenuta di San Rossore ed è caratterizzata da un bosco misto composto da Populus alba, P. x canescens, Fraxinus angustifolia e Alnus glutinosa.; l'area B è situata presso il Lago di Massaciuccoli ed è costituita da una popolazione frammentata di Populus sp Sono state esaminate le popolazioni di Populus presenti nelle due aree insieme a due varietà coltivate. Le due aree sono state anche caratterizzate per la loro copertura erbacea. Sono stati utilizzati marcatori microsatelliti nucleari per determinare la variabilità genetica delle popolazioni di pioppo e il livello d'incrocio tra le popolazioni spontanee e quelle coltivate. Inoltre sono state studiate le popolazioni d'insetti presenti sui maschi e sulle femmine di pioppo durante il periodo di fioritura. Per determinare la densità e la composizione delle specie erbacee, nelle aree di studio è stato utilizzato l'approccio multiscala standardizzato di Dengler. Le possibili variazioni di distribuzione e/o densità delle specie sono state valutate seguendo l'approccio di Braun Blanquet. Le osservazioni fatte finora sullo strato erbaceo mostrano una certa variabilità nella distribuzione delle specie tra un quadrato e l'altro, dovuta probabilmente alle caratteristiche micro-topologiche del sito di studio. L'analisi della biodiversità degli artropodi presenti sulle infiorescenze del pioppo indica un'evidente differenza tra alberi dei due sessi e un numero piuttosto basso di specie. Nelle infiorescenze maschili predominano le larve di dittero seguite da coleotteri coccinellidi e ragni, nelle infiorescenze femminili, invece, predominano i ragni seguiti dai coleotteri curculionidi e dalle larve di lepidotteri. I dati dei microsatelliti sono stati analizzati con il software Geneland. I risultati di questa analisi mostrano tre gruppi distinti nell'area A. Il primo gruppo è composto da individui con lo stesso genotipo, probabilmente polloni, mentre gli altri due gruppi mostrano flusso genico all'interno e tra gruppi indicando che le altre specie arboree nell'area impediscono solo in parte il flusso genico. Nell'area B sono presenti due gruppi che mostrano un livello più alto di flusso genico rispetto all'area A. Questa popolazione, infatti, si trova in un'area più aperta in cui di solito il flusso genico è favorito. In generale il livello di biodiversità nelle aree è alto e in particolare il flusso genico nel lago di Massaciuccoli è considerevole. Quindi una possibile coltivazione di pioppo transgenico vicino a queste aree protette potrebbe influenzare la loro diversità. Lo sviluppo del QMI basato su dati sperimentali è in corso.

Published
2011

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