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443 results on '"Fleming, Stewart"'

1. Experience of a systematic approach to care and prevention of fragility fractures in New Zealand

Author

Gill, Christine Ellen, Mitchell, Paul James, Clark, Jan, Cornish, Jillian, Fergusson, Peter, Gilchrist, Nigel, Hayman, Lynne, Hornblow, Sue, Kim, David, Mackenzie, Denise, Milsom, Stella, von Tunzelmann, Adrienne, Binns, Elizabeth, Fergusson, Kim, Fleming, Stewart, Hurring, Sarah, Lilley, Rebbecca, Miller, Caroline, Navarre, Pierre, Pettett, Andrea, Sankaran, Shankar, Seow, Min Yee, Sincock, Jenny, Ward, Nicola, Wright, Mark, Close, Jacqueline Clare Therese, Harris, Ian Andrew, Armstrong, Elizabeth, Hallen, Jamie, Hikaka, Joanna, Kerse, Ngaire, Vujnovich, Andrea, Ganda, Kirtan, Seibel, Markus Joachim, Jackson, Thomas, Kennedy, Paul, Malpas, Kirsten, Dann, Leona, Shuker, Carl, Dunne, Colleen, Wood, Philip, Magaziner, Jay, Marsh, David, Tabu, Irewin, Cooper, Cyrus, Halbout, Philippe, Javaid, Muhammad Kassim, Åkesson, Kristina, Mlotek, Anastasia Soulié, Brûlé-Champagne, Eric, and Harris, Roger

Published
2022
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9. Challenges in Pathologic Staging of Renal Cell Carcinoma: A Study of Interobserver Variability Among Urologic Pathologists

Author

Williamson, Sean R., Rao, Priya, Hes, Ondrej, Epstein, Jonathan I., Smith, Steven C., Picken, Maria M., Zhou, Ming, Tretiakova, Maria S., Tickoo, Satish K., Chen, Ying-Bei, Reuter, Victor E., Fleming, Stewart, Maclean, Fiona M., Gupta, Nilesh S., Kuroda, Naoto, Delahunt, Brett, Mehra, Rohit, Przybycin, Christopher G., Cheng, Liang, Eble, John N., Grignon, David J., Moch, Holger, Lopez, Jose I., Kunju, Lakshmi P., Tamboli, Pheroze, Srigley, John R., Amin, Mahul B., Martignoni, Guido, Hirsch, Michelle S., Bonsib, Stephen M., and Trpkov, Kiril

Published
2018
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25. When gluttony ruled!

Author

Ruscillo, Deborah and Fleming, Stewart J.

Subjects
Civilization, Greco-Roman -- History, Anthropology/archeology/folklore
Abstract

Evidence of the significant role played by feasting in Roman society provided by classical literature and by mosaics of banquets is described. Banquets included many courses and were accompanied by wine. Typical recipes are given.

Published
2001

29. Immunocytochemical studies of the developmental biology and pathology of the human kidney

Author

Fleming, Stewart

Subjects
616.07
Abstract

This thesis describes my study of normal and abnormal differentiation in the human kidney. Firstly, I have used immunocytochemical techniques to map the appearance of differentiation markers during renal organogenesis. I have shown that at the stage of tubular induction the induced cells underwent transferrin dependent proliferation. Simultaneously there was a change in intermediate filament phenotype from vimentin to cytokeratin. Tubular epithelium continued to express cytokeratins during development but in the glomerular epithelium cytokeratin expression was transient and was lost during glomerular maturation. As tubular development progressed the segregation of proximal and distal tubular epithelium was marked by the expression of different cell surface antigens, brush border antigen in the proximal tubule and epithelial membrane antigen in the distal tubule. Further developmental progress was accompanied by the appearance of new maturation markers such as ferritin, alpha-1-antitrypsin and carbonic anhydrase C. It is the ureteric bud which induces tubulogenesis from the metanephric blastema. During this process the ureteric bud expressed a specialised group of cell surface carbohydrates, which have been shown to be important in cell interactions during other embryogenic processes. These molecules were lost as the ureteric bud differentiated to the collecting duct epithelium. Changes in the extracellular matrix, vascular tree and juxta-glomerular apparatus have also been described. I have concluded this first part of the study by formulating a classification of the cell markers according to the developmental stage and site at which they first appeared. I have then used the same markers to study differentiation in different types of renal dysplasia and renal neoplasms. These are diseases in which differentiation may be abnormal. In the cases of renal dysplasia I identified two different types of abnormality of differentiation. Firstly, the different components of the nephron showed evidence of developmental arrest. There was morphological immaturity and a failure of all segments of the nephron to express various maturation markers. Secondly, in the mesenchymal compartment heterologous differentiation into non-renal tissues such as cartilage and fat was a frequent occurrence. The renal neoplasms also showed different forms of abnormal differentiation. The tubular elements of nephroblastoma expressed cytokeratins and either epithelial membrane antigen or brush border antigen but did not express the mature tubular markers such as carbonic anhydrase C and ferritin. The mesenchyme of some cases contained morphologically and immunologically detectable heterologous tissues particularly skeletal muscle. I have provided immunocytochemical evidence that the type B tubules in nephroblastoma are derived from the ureteric bud and grow into the tumours from the adjacent kidney. It has previously been proposed that renal cell carcinomas arise from the proximal tubule, but I have herein shown that these tumours co-express markers of both proximal and distal tubular epithelium. Similar results have been seen in regenerative epithelium. Neoplastic epithelial cells in the majority of renal cell carcinomas expressed both the vimentin and cytokeratin types of intermediate filament protein. The proliferation of the renal tumours has been studied by the monoclonal antibodies Ki 67 and HB 21 . Renin containing cells have been found in a proportion of both of the main types of renal neoplasm. These were characteristically seen in a perivascular distribution. During the course of the study a distinct type of renal carcinoma was identified. I have called this tumour collecting duct carcinoma because the tumour cells had the same cytokeratin phenotype and cell surface markers as normal collecting duct epithelium. Finally I have discussed these various results in the context of our present knowledge of cell commitment and differentiation in the kidney and other tissues. The lack of heterologous epithelial differentiation in renal pathology has suggested that the commitment to renal differentiation persists in disease states. The renal connective tissues showed no such commitment and heterologous differentiation in this cell compartment was relatively common.

Published
1988

44. Cystic fibrosis in the mouse by targeted insertional mutagenesis

Author

Dorin, Julia R., Dickinson, Paul, Alton, Eric W.F.W., Smith, Stephen N., Geddes, Duncan M., Stevenson, Barbara J., Kimber, Wendy L., Fleming, Stewart, Clarke, Alan R., Hooper, Martin L., Anderson, Louise, Beddington, Rosa S.P., and Porteous, David J.

Subjects
Cystic fibrosis -- Models, Mice as laboratory animals -- Innovations, Mutagenesis -- Usage, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

A new mouse model for cystic fibrosis (CF) has been devised that should be useful in trials of potential treatments for this deadly autosomal recessive disorder. The new model was produced through mutagenesis or the genetic disruption of the CF transmembrane conductance regulator gene in murine embryonic stem cells. The detection of the characteristic CF pathophysiology in the mice such as abnormal chloride ion transport verified the similarity of the model to human CF.

Published
1992

47. Dataset for the reporting of renal biopsy for tumour: recommendations from the International Collaboration on Cancer Reporting (ICCR)

Author

Delahunt, Brett, primary, Srigley, John R, additional, Judge, Meagan, additional, Amin, Mahul, additional, Billis, Athanase, additional, Camparo, Philippe, additional, Fleming, Stewart, additional, Griffiths, David, additional, Lopez-Beltran, Antonio, additional, Martignoni, Guido, additional, Moch, Holger, additional, Nacey, John N, additional, Zhou, Ming, additional, and Evans, Andrew John, additional

Published
2019
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49. Data set for the reporting of carcinoma of renal tubular origin: recommendations from the International Collaboration on Cancer Reporting (ICCR)

Author

Delahunt, Brett, primary, Srigley, John R, additional, Judge, Meagan J, additional, Amin, Mahul B, additional, Billis, Athanase, additional, Camparo, Philippe, additional, Evans, Andrew J, additional, Fleming, Stewart, additional, Griffiths, David F, additional, Lopez‐Beltran, Antonio, additional, Martignoni, Guido, additional, Moch, Holger, additional, Nacey, John N, additional, and Zhou, Ming, additional

Published
2019
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50. Phenotypic dissection of the mouse Ren-1(d) knockout by complementation with human renin

Author

Buckley, Charlotte, Nelson, Robert J., Mullins, Linda J., Sharp, Matthew G. F., Fleming, Stewart, Kenyon, Christopher J., Semprini, Sabrina, Steppan, Dominik, Peti-Peterdi, Janos, Kurtz, Armin, Christian, Helen, and Mullins, John J.

Subjects
Mice, Knockout, renin angiotensin system, urogenital system, animal model, Genetic Complementation Test, human renin, Cell Biology, transgenic mice, confocal microscopy, urologic and male genital diseases, juxtaglomerular, macula densa, Juxtaglomerular Apparatus, QR, secretion, Mice, granulation, renin, immunochemistry, Journal Article, Animals, Humans, Transgenes, electron microscopy (EM), mouse
Abstract

Normal renin synthesis and secretion is important for the maintenance of juxtaglomerular apparatus architecture. Mice lacking a functional Ren-1(d) gene are devoid of renal juxtaglomerular cell granules and exhibit an altered macula densa morphology. Due to the species-specificity of renin activity, transgenic mice are ideal models for experimentally investigating and manipulating expression patterns of the human renin gene in a native cellular environment without confounding Renin-angiotensin-system interactions. A 55 kb transgene encompassing the human renin locus was crossed onto the mouse Ren-1(d)-null background, restoring granulation in juxtaglomerular cells. Correct processing of human renin in dense core granules was confirmed by immunogold labelling. After stimulation of the renin-angiotensin system, juxtaglomerular cells contained rhomboid protogranules with paracrystalline contents, dilated rough endoplasmic reticulum and electron-lucent granular structures. However, complementation of Ren-1(d-/-) mice with human renin was unable to rescue the abnormality seen in macula densa structure. The juxtaglomerular apparatus was still able to respond to tubuloglomerular feedback in isolated perfused juxtaglomerular apparatus preparations, although minor differences in glomerular tuft contractility and macula densa cell calcium handling were observed. This study reveals that the human renin protein is able to complement the mouse Ren-1(d-/-) non-granulated defect and suggests that granulopoiesis requires a structural motif that is conserved between the mouse Ren-1(d) and human renin proteins. It also suggests that the altered macula densa phenotype is related to the activity of the renin-1d enzyme in a local juxtaglomerular renin-angiotensin system.

Published
2017

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