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8,249 results on '"Flori A"'

1. Durability of Original Monovalent mRNA Vaccine Effectiveness Against COVID-19 Omicron-Associated Hospitalization in Children and Adolescents - United States, 2021-2023.

Author

Zambrano, Laura, Newhams, Margaret, Simeone, Regina, Payne, Amanda, Wu, Michael, Orzel-Lockwood, Amber, Halasa, Natasha, Calixte, Jemima, Pannaraj, Pia, Mongkolrattanothai, Kanokporn, Boom, Julie, Sahni, Leila, Kamidani, Satoshi, Chiotos, Kathleen, Cameron, Melissa, Maddux, Aline, Irby, Katherine, Schuster, Jennifer, Mack, Elizabeth, Biggs, Austin, Coates, Bria, Michelson, Kelly, Bline, Katherine, Nofziger, Ryan, Crandall, Hillary, Hobbs, Charlotte, Gertz, Shira, Heidemann, Sabrina, Bradford, Tamara, Walker, Tracie, Schwartz, Stephanie, Staat, Mary, Bhumbra, Samina, Hume, Janet, Kong, Michele, Stockwell, Melissa, Connors, Thomas, Cullimore, Melissa, Flori, Heidi, Levy, Emily, Cvijanovich, Natalie, Zinter, Matt, Maamari, Mia, Bowens, Cindy, Zerr, Danielle, Guzman-Cottrill, Judith, Gonzalez, Ivan, Campbell, Angela, and Randolph, Adrienne

Subjects
Humans, Adolescent, Child, United States, COVID-19 Vaccines, COVID-19, mRNA Vaccines, Vaccine Efficacy, SARS-CoV-2, Hospitalization, RNA, Messenger
Abstract

Pediatric COVID-19 vaccination is effective in preventing COVID-19-related hospitalization, but duration of protection of the original monovalent vaccine during SARS-CoV-2 Omicron predominance merits evaluation, particularly given low coverage with updated COVID-19 vaccines. During December 19, 2021-October 29, 2023, the Overcoming COVID-19 Network evaluated vaccine effectiveness (VE) of ≥2 original monovalent COVID-19 mRNA vaccine doses against COVID-19-related hospitalization and critical illness among U.S. children and adolescents aged 5-18 years, using a case-control design. Too few children and adolescents received bivalent or updated monovalent vaccines to separately evaluate their effectiveness. Most case-patients (persons with a positive SARS-CoV-2 test result) were unvaccinated, despite the high frequency of reported underlying conditions associated with severe COVID-19. VE of the original monovalent vaccine against COVID-19-related hospitalizations was 52% (95% CI = 33%-66%) when the most recent dose was administered

Published
2024

2. Heterogeneous drivers of overnight and same-day visits

Author

Scotti, Francesco, Flori, Andrea, Secchi, Piercesare, Arena, Marika, and Azzone, Giovanni

Subjects
Economics - General Economics
Abstract

This paper aims to explore the factors stimulating different tourism behaviours, with specific reference to same-day visits and overnight stays. To this aim, we employ mobile network data referred to the area of Lombardy. The paper highlights that larger availability of tourism accommodations, cultural and natural endowments are relevant factors explaining overnight stays. Conversely, temporary entertainment and transportation facilities increase municipalities attractiveness for same-day visits. The results also highlight a trade-off in the capability of municipalities of being attractive in connection to both the tourism behaviours, with higher overnight stays in areas with more limited same-day visits. Mobile data offer a spatial and temporal granularity allowing to detect relevant patterns and support the design of tourism precision policies.

Published
2024

3. Budget impact analysis of introducing digital breast tomosynthesis in breast cancer screening in Italy

Author

Djuric, Olivera, Deandrea, Silvia, Mantellini, Paola, Sardanelli, Francesco, Venturelli, Francesco, Montemezzi, Stefania, Vecchio, Riccardo, Bucchi, Lauro, Senore, Carlo, Giordano, Livia, Paci, Eugenio, Bonifacino, Adriana, Calabrese, Massimo, Caumo, Francesca, Degrassi, Flori, Sassoli de’ Bianchi, Priscilla, Battisti, Francesca, Zappa, Marco, Pattacini, Pierpaolo, Campari, Cinzia, Nitrosi, Andrea, Di Leo, Giovanni, Frigerio, Alfonso, Magni, Veronica, Fornasa, Francesca, Romanucci, Giovanna, Falini, Patrizia, Auzzi, Noemi, Armaroli, Paola, and Giorgi Rossi, Paolo

Published
2024
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4. Organizational impact of systemic implementation of digital breast tomosynthesis as a primary test for breast cancer screening in Italy

Author

Djuric, Olivera, Deandrea, Silvia, Mantellini, Paola, Sardanelli, Francesco, Venturelli, Francesco, Montemezzi, Stefania, Vecchio, Riccardo, Bucchi, Lauro, Senore, Carlo, Giordano, Livia, Paci, Eugenio, Bonifacino, Adriana, Calabrese, Massimo, Caumo, Francesca, Degrassi, Flori, Sassoli de’ Bianchi, Priscilla, Battisti, Francesca, Zappa, Marco, Pattacini, Pierpaolo, Campari, Cinzia, Nitrosi, Andrea, Di Leo, Giovanni, Frigerio, Alfonso, Magni, Veronica, Fornasa, Francesca, Romanucci, Giovanna, Falini, Patrizia, Auzzi, Noemi, Armaroli, Paola, and Giorgi Rossi, Paolo

Published
2024
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5. Oil palm (Elaeis guineensis Jacq.) genetic differences in mineral nutrition: environmental effects on leaflet mineral concentrations of four oil palm progenies☆

Author

Dassou Olivier Sènankpon, Ollivier Jean, Vanhove Wouter, Aholoukpè Hervé, Impens Reinout, Bonneau Xavier, Flori Albert, Durand-Gasselin Tristan, Augustin Sinsin Brice, Adjanohoun Adolphe, and Van Damme Patrick

Subjects
oil palm genetic origins, genetic determination, leaf analysis, leaflet mineral concentrations, Oils, fats, and waxes, TP670-699
Abstract

Oil palm fertilizer requirements are based on leaflet mineral concentrations. Four oil palm progenies representing a wide genetic diversity of Elaeis guineensis species and with contrasting K and Mg leaflet concentrations were tested in Indonesia and Nigeria, environments which differ predominantly in climate. During 5 years, we compared oil palm progenies’ leaflet mineral concentrations between both countries under abundant fertilizer applications to investigate the extent to which they depend on the environment. In the two studied environments, leaflet concentrations significantly differed between progenies for K, Mg and Ca, but the country effect was not found significant (p = 0.352) for any leaflet mineral’s concentration. In both countries, progenies ranked similarly in their mineral categories (lowest and highest cation concentrations within the 4 progenies population), indicating that leaflet mineral concentrations in the tested oil palm progenies are mainly determined by their genetic background. For each progeny, with abundant fertilization, K, Mg and Ca proportions to total leaf cation charge (TLCC) were similar, irrespective of the environments in which the palms were cultivated. We have strong indications that foliar concentrations of K, Mg and Ca are determined by genetic factors which dominate the environmental effect. However, it remains uncertain whether differences in oil palm foliar concentrations between different oil palm progenies imply that they require specific fertilizer amounts to attain an optimal production.

Published
2022
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6. Oil palm (Elaeis guineensis Jacq.) genetic differences in mineral nutrition: potassium and magnesium effects on morphological characteristics of four oil palm progenies in Nigeria (West Africa)☆

Author

Dassou Olivier Sènankpon, Bonneau Xavier, Aholoukpè Hervé, Vanhove Wouter, Ollivier Jean, Peprah Stephen, Flori Albert, Durand-Gasselin Tristan, Mensah Apollinaire Guy, Sinsin Brice Augustin, and Van Damme Patrick

Subjects
oil palm, genetic origin, genetic background, morphological characteristics, growth, leaflet mineral concentrations, Oils, fats, and waxes, TP670-699
Abstract

We compared four oil palm (Elaeis guineensis Jacq.) progenies’ morphological growth characteristics to reveal genotypic differences in plant growth and assess their adaptability in Nigeria’s environment in response to different levels of potassium chloride (KCl) and kieserite fertilizer applications. The studied progenies (C1, C2 and C3 of Deli × La Mé origin and C4 of Deli × Yangambi origin) represent a wide genetic diversity of oil palm and have shown among a population of 116 different progenies, a contrasting K and Mg leaflet concentrations that covered the extreme ranges of leaflet concentrations in these minerals. The trial consisted of a completely randomized split-plot factorial design with six replicates, where progenies, considered as sub-factor were treated with combinations of 3 levels of potassium chloride (0, 1.5, 3.0 kg of KCl palm−1 year−1) and kieserite (0, 0.75, 1.5 kg of MgSO4 palm−1 year−1) fertilizers (main factor), respectively. Growth characteristics differed significantly among progenies, but not in all studied years. In all progenies, KCl treatments significantly increased the average annual collar girth increment and projected canopy area. Adding 3.0 kg palm−1 year−1 of KCl significantly increased the total leaf area of progeny C4. Kieserite applications did not have an effect on progenies’ growth characteristics whereas potassium showed to be the main mineral needed for oil palm growth. It was shown that with equal amounts of fertilizers applied, progeny C3 had better morphological traits than the other progenies, suggesting that the effective nutrient requirements should be assessed for each individual progeny and that fertilization should be adapted accordingly.

Published
2022
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8. Statistical characterization of residual noise in the low-rank approximation filter framework, general theory and application to hyperpolarized tracer spectroscopy

Author

Francischello, R., Santarelli, M. F., Flori, A., Menichetti, L., and Geppi, M.

Subjects
Physics - Data Analysis, Statistics and Probability
Abstract

The use of low-rank approximation filters in the field of NMR is increasing due to their flexibility and effectiveness. Despite their ability to reduce the Mean Square Error between the processed signal and the true signal is well known, the statistical distribution of the residual noise is still undescribed. In this article, we show that low-rank approximation filters are equivalent to linear filters, and we calculate the mean and the covariance matrix of the processed data. We also show how to use this knowledge to build a maximum likelihood estimator, and we test the estimator's performance with a Montecarlo simulation of a 13C pyruvate metabolic tracer. While the article focuses on NMR spectroscopy experiment with hyperpolarized tracer, we also show that the results can be applied to tensorial data (e.g. using HOSVD) or 1D data (e.g. Cadzow filter)., Comment: 27 pages, 7 figures

Published
2023

9. Effectiveness of Maternal mRNA COVID-19 Vaccination During Pregnancy Against COVID-19-Associated Hospitalizations in Infants Aged <6 Months During SARS-CoV-2 Omicron Predominance - 20 States, March 9, 2022-May 31, 2023.

Author

Simeone, Regina, Zambrano, Laura, Halasa, Natasha, Fleming-Dutra, Katherine, Newhams, Margaret, Wu, Michael, Orzel-Lockwood, Amber, Kamidani, Satoshi, Pannaraj, Pia, Irby, Katherine, Maddux, Aline, Hobbs, Charlotte, Cameron, Melissa, Boom, Julie, Sahni, Leila, Kong, Michele, Nofziger, Ryan, Schuster, Jennifer, Crandall, Hillary, Hume, Janet, Staat, Mary, Mack, Elizabeth, Bradford, Tamara, Heidemann, Sabrina, Levy, Emily, Gertz, Shira, Bhumbra, Samina, Walker, Tracie, Bline, Katherine, Michelson, Kelly, Zinter, Matt, Flori, Heidi, Campbell, Angela, and Randolph, Adrienne

Subjects
Female, Pregnancy, Infant, Humans, SARS-CoV-2, COVID-19, COVID-19 Vaccines, RNA, Messenger, Stored, Case-Control Studies, Hospitalization, Mothers, Vaccination
Abstract

Infants aged

Published
2023

12. Precision agriculture in oil palm plantations: diagnostic tools for sustainable N and K nutrient supply

Author

Dubos Bernard, Baron Victor, Bonneau Xavier, Dassou Olivier, Flori Albert, Impens Reinout, Ollivier Jean, and Pardon Lénaïc

Subjects
oil palm, fertilization, nutrient balance, leaf analyses, environmental risk, Oils, fats, and waxes, TP670-699
Abstract

Predicting the fertilizer requirements of an oil palm plantation has long been a difficult task. Two main methods have emerged. Leaf analyses (LA) were used for fertilization management as early as the 1950s. Leaf contents are compared to optimum references, making it possible to adjust the fertilizer rates applied in each block. Another approach, based on the nutrient balance (NB), is to evaluate and replace nutrients that are exported from the field, or immobilized by the plant. Plantations must adopt environmentally friendly practices; in particular, fertilizer inputs must be estimated with sufficient precision to achieve the highest possible yields, without applying excessive amounts of nutrients in relation to plant demand and the storage capacity of soils. We questioned the relevance of each method for achieving these objectives. We did so using some long-term fertilization trials to compare the optimum N and K rates recommended by each method in the adult phase. It appeared that LA led to moderate rates compared to NB. It also appeared that calculating a precise nutrient balance on a field scale was hampered by a lack of precise information (i) about the biomasses produced and their composition and (ii) about the highly variable outputs of the environmental losses. On the other hand, LA provided a simple indicator of the ability for each block to achieve its potential yield. We believe that this perfectible method is more protective of the environment, without the risk of a significant decrease in yields or a decrease in soil mineral reserves.

Published
2019
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13. NFKB2 haploinsufficiency identified via screening for IFN-α2 autoantibodies in children and adolescents hospitalized with SARS-CoV-2–related complications

Author

Bodansky, Aaron, Vazquez, Sara E, Chou, Janet, Novak, Tanya, Al-Musa, Amer, Young, Cameron, Newhams, Margaret, Kucukak, Suden, Zambrano, Laura D, Mitchell, Anthea, Wang, Chung-Yu, Moffitt, Kristin, Halasa, Natasha B, Loftis, Laura L, Schwartz, Stephanie P, Walker, Tracie C, Mack, Elizabeth H, Fitzgerald, Julie C, Gertz, Shira J, Rowan, Courtney M, Irby, Katherine, Sanders, Ronald C, Kong, Michele, Schuster, Jennifer E, Staat, Mary A, Zinter, Matt S, Cvijanovich, Natalie Z, Tarquinio, Keiko M, Coates, Bria M, Flori, Heidi R, Dahmer, Mary K, Crandall, Hillary, Cullimore, Melissa L, Levy, Emily R, Chatani, Brandon, Nofziger, Ryan, Investigators, Overcoming COVID-19 Network Study Group, Yates, Masson, Smith, Chelsea, Zinter, MattS, McLaughlin, Gwenn, Randolph, Adrienne G, Newhams, Margaret M, Moon, Hye Kyung, Kobayashi, Takuma, Melo, Jeni, Chen, Sabrina R, Behl, Supriya, Drapeau, Noelle M, McCulloh, Russell J, Nofziger, Ryan A, Staat, Mary Allen, Rohlfs, Chelsea C, Reed, Nelson, Geha, Raif S, DeRisi, Joseph, Campbell, Angela P, and Anderson, Mark

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Lung, Vaccine Related, Infectious Diseases, Rare Diseases, Pneumonia, Clinical Research, Prevention, Emerging Infectious Diseases, Biodefense, Pediatric, Genetics, Autoimmune Disease, Aetiology, 2.1 Biological and endogenous factors, Inflammatory and immune system, Good Health and Well Being, Adult, Humans, Child, Adolescent, SARS-CoV-2, COVID-19, Autoantibodies, NF-kappa B, Haploinsufficiency, Leukocytes, Mononuclear, Interferon Type I, NF-kappa B p52 Subunit, Anti-interferon autoantibody, MIS-C, NFKB2, inborn errors of immunity, Overcoming COVID-19 Network Study Group Investigators, Immunology, Allergy
Abstract

BackgroundAutoantibodies against type I IFNs occur in approximately 10% of adults with life-threatening coronavirus disease 2019 (COVID-19). The frequency of anti-IFN autoantibodies in children with severe sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is unknown.ObjectiveWe quantified anti-type I IFN autoantibodies in a multicenter cohort of children with severe COVID-19, multisystem inflammatory syndrome in children (MIS-C), and mild SARS-CoV-2 infections.MethodsCirculating anti-IFN-α2 antibodies were measured by a radioligand binding assay. Whole-exome sequencing, RNA sequencing, and functional studies of peripheral blood mononuclear cells were used to study any patients with levels of anti-IFN-α2 autoantibodies exceeding the assay's positive control.ResultsAmong 168 patients with severe COVID-19, 199 with MIS-C, and 45 with mild SARS-CoV-2 infections, only 1 had high levels of anti-IFN-α2 antibodies. Anti-IFN-α2 autoantibodies were not detected in patients treated with intravenous immunoglobulin before sample collection. Whole-exome sequencing identified a missense variant in the ankyrin domain of NFKB2, encoding the p100 subunit of nuclear factor kappa-light-chain enhancer of activated B cells, aka NF-κB, essential for noncanonical NF-κB signaling. The patient's peripheral blood mononuclear cells exhibited impaired cleavage of p100 characteristic of NFKB2 haploinsufficiency, an inborn error of immunity with a high prevalence of autoimmunity.ConclusionsHigh levels of anti-IFN-α2 autoantibodies in children and adolescents with MIS-C, severe COVID-19, and mild SARS-CoV-2 infections are rare but can occur in patients with inborn errors of immunity.

Published
2023

14. Microbiota alterations associated with vascular diseases: postbiotics as a next-generation magic bullet for gut-vascular axis

Author

Lorenzo Flori, Giada Benedetti, Alma Martelli, and Vincenzo Calderone

Subjects
Vascular diseases, microbiota, gut-vascular axis, postbiotics, aging, short‑chain fatty acids, Therapeutics. Pharmacology, RM1-950
Abstract

The intestinal microbiota represents a key element in maintaining the homeostasis and health conditions of the host. Vascular pathologies and other risk factors such as aging have been recently associated with dysbiosis. The qualitative and quantitative alteration of the intestinal microbiota hinders correct metabolic homeostasis, causing structural and functional changes of the intestinal wall itself. Impairment of the intestinal microbiota, combined with the reduction of the barrier function, worsen the pathological scenarios of peripheral tissues over time, including the vascular one. Several experimental evidence, collected in this review, describes in detail the changes of the intestinal microbiota in dysbiosis associated with vascular alterations, such as atherosclerosis, hypertension, and endothelial dysfunction, the resulting metabolic disorders and how these can impact on vascular health. In this context, the gut-vascular axis is considered, for the first time, as a merged unit involved in the development and progression of vascular pathologies and as a promising target. Current approaches for the management of dysbiosis such as probiotics, prebiotics and dietary modifications act mainly on the intestinal district. Postbiotics, described as preparation of inanimate microorganisms and/or their components that confers health benefits on the host, represent an innovative strategy for a dual management of intestinal dysbiosis and vascular pathologies. In this context, this review has the further purpose of defining the positive effects of the supplementation of bacterial strains metabolites (short‑chain fatty acids, exopolysaccharides, lipoteichoic acids, gallic acid, and protocatechuic acid) restoring intestinal homeostasis and acting directly on the vascular district through the gut-vascular axis.

Published
2024
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15. Executive Summary of the Second International Guidelines for the Diagnosis and Management of Pediatric Acute Respiratory Distress Syndrome (PALICC-2).

Author

Emeriaud, Guillaume, López-Fernández, Yolanda, Iyer, Narayan, Bembea, Melania, Agulnik, Asya, Barbaro, Ryan, Baudin, Florent, Bhalla, Anoopindar, Brunow de Carvalho, Werther, Carroll, Christopher, Cheifetz, Ira, Chisti, Mohammod, Cruces, Pablo, Curley, Martha, Dahmer, Mary, Dalton, Heidi, Erickson, Simon, Essouri, Sandrine, Fernández, Analía, Flori, Heidi, Grunwell, Jocelyn, Jouvet, Philippe, Killien, Elizabeth, Kneyber, Martin, Kudchadkar, Sapna, Korang, Steven, Lee, Jan, Macrae, Duncan, Maddux, Aline, Modesto I Alapont, Vicent, Morrow, Brenda, Nadkarni, Vinay, Napolitano, Natalie, Newth, Christopher, Pons-Odena, Martí, Quasney, Michael, Rajapreyar, Prakadeshwari, Rambaud, Jerome, Randolph, Adrienne, Rimensberger, Peter, Rowan, Courtney, Sanchez-Pinto, L, Sapru, Anil, Sauthier, Michael, Shein, Steve, Smith, Lincoln, Steffen, Katerine, Takeuchi, Muneyuki, Thomas, Neal, Tse, Sze, Valentine, Stacey, Ward, Shan, Watson, R, Yehya, Nadir, Zimmerman, Jerry, and Khemani, Robinder

Subjects
Child, Humans, Respiratory Distress Syndrome, Respiration, Artificial, Acute Lung Injury, Consensus
Abstract

OBJECTIVES: We sought to update our 2015 work in the Second Pediatric Acute Lung Injury Consensus Conference (PALICC-2) guidelines for the diagnosis and management of pediatric acute respiratory distress syndrome (PARDS), considering new evidence and topic areas that were not previously addressed. DESIGN: International consensus conference series involving 52 multidisciplinary international content experts in PARDS and four methodology experts from 15 countries, using consensus conference methodology, and implementation science. SETTING: Not applicable. PATIENTS: Patients with or at risk for PARDS. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Eleven subgroups conducted systematic or scoping reviews addressing 11 topic areas: 1) definition, incidence, and epidemiology; 2) pathobiology, severity, and risk stratification; 3) ventilatory support; 4) pulmonary-specific ancillary treatment; 5) nonpulmonary treatment; 6) monitoring; 7) noninvasive respiratory support; 8) extracorporeal support; 9) morbidity and long-term outcomes; 10) clinical informatics and data science; and 11) resource-limited settings. The search included MEDLINE, EMBASE, and CINAHL Complete (EBSCOhost) and was updated in March 2022. Grading of Recommendations, Assessment, Development, and Evaluation methodology was used to summarize evidence and develop the recommendations, which were discussed and voted on by all PALICC-2 experts. There were 146 recommendations and statements, including: 34 recommendations for clinical practice; 112 consensus-based statements with 18 on PARDS definition, 55 on good practice, seven on policy, and 32 on research. All recommendations and statements had agreement greater than 80%. CONCLUSIONS: PALICC-2 recommendations and consensus-based statements should facilitate the implementation and adherence to the best clinical practice in patients with PARDS. These results will also inform the development of future programs of research that are crucially needed to provide stronger evidence to guide the pediatric critical care teams managing these patients.

Published
2023

16. Risk factors for health impairments in children after hospitalization for acute COVID-19 or MIS-C.

Author

Maddux, Aline, Young, Cameron, Kucukak, Suden, Zambrano, Laura, Newhams, Margaret, Rollins, Caitlin, Halasa, Natasha, Gertz, Shira, Mack, Elizabeth, Schwartz, Stephanie, Kong, Michele, Loftis, Laura, Irby, Katherine, Rowan, Courtney, Tarquinio, Keiko, Zinter, Matt, Crandall, Hillary, Cvijanovich, Natalie, Schuster, Jennifer, Fitzgerald, Julie, Staat, Mary, Hobbs, Charlotte, Nofziger, Ryan, Shein, Steven, Flori, Heidi, Cullimore, Melissa, Chatani, Brandon, Levy, Emily, Typpo, Katri, Hume, Janet, Campbell, Angela, and Randolph, Adrienne

Subjects
COVID-19, COVID-19 post-intensive care syndrome, MIS-C, SARS-CoV-2, critical care outcomes, multisystem inflammatory syndrome in children, pediatrics, post-acute COVID-19 syndrome
Abstract

OBJECTIVE: To identify risk factors for persistent impairments after pediatric hospitalization for acute coronavirus disease 2019 (COVID-19) or multisystem inflammatory syndrome in children (MIS-C) during the SARS-CoV-2 pandemic. METHODS: Across 25 U.S. Overcoming COVID-19 Network hospitals, we conducted a prospective cohort study of patients

Published
2023

19. Author Correction: Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C.

Author

Tang, Juanjie, Novak, Tanya, Hecker, Julian, Grubbs, Gabrielle, Zahra, Fatema Tuz, Bellusci, Lorenza, Pourhashemi, Sara, Chou, Janet, Moffitt, Kristin, Halasa, Natasha B, Schwartz, Stephanie P, Walker, Tracie C, Tarquinio, Keiko M, Zinter, Matt S, Staat, Mary A, Gertz, Shira J, Cvijanovich, Natalie Z, Schuster, Jennifer E, Loftis, Laura L, Coates, Bria M, Mack, Elizabeth H, Irby, Katherine, Fitzgerald, Julie C, Rowan, Courtney M, Kong, Michele, Flori, Heidi R, Maddux, Aline B, Shein, Steven L, Crandall, Hillary, Hume, Janet R, Hobbs, Charlotte V, Tremoulet, Adriana H, Shimizu, Chisato, Burns, Jane C, Chen, Sabrina R, Moon, Hye Kyung, Lange, Christoph, Randolph, Adrienne G, and Khurana, Surender

Subjects
Good Health and Well Being
Published
2022

27. Immunocompromised-Associated Pediatric Acute Respiratory Distress Syndrome: Experience From the 2016/2017 Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology Prospective Cohort Study*

Author

Gertz, Shira J., Bhalla, Anoopindar, Chima, Ranjit S., Emeriaud, Guillaume, Fitzgerald, Julie C., Hsing, Deyin D., Jeyapalan, Asumthia S., Pike, Francis, Sallee, Colin J., Thomas, Neal J., Yehya, Nadir, Rowan, Courtney M., Sforza, Jesica, Poterala, Rossana, Fernandez, Analia, Avila Vera, Antonio, Orqueda, Daniel, Agueda Vidal, Nilda, Rosemary, Deheza, Turon, Gonzalo, Monjes, Cecilia, Fernando Espanol, Segundo, Siaba Serrate, Alejandro, Iolster, Thomas, Torres, Silvio, Cinquegrani, Karina, Jose Montes, Maria, Capocasa, Patricia, Ferreyra, Marcela, Castellani, Pablo, Giampieri, Martin, Pedraza, Claudia, Martin Landry, Luis, Althabe, Maria, Vanesa Fortini, Yanina, Botta, Priscila, Paziencia, Fernando, Erickson, Simon, Barr, Samantha, Shea, Sara, Butt, Warwick, Delzoppo, Carmel, Pintimalla, Alyssa, Martinez Leon, Alejandro Fabio, Guzman Rivera, Gustavo Alfredo, Jouvet, Philippe, Emeriaud, Guillaume, Dumitrascu, Mariana, Ellen French, Mary, Caro, Daniel, Castillo, I, Andres, E., Cruces Romero, Pablo, Medina, Tania, Pavez Madrid, Paula, Cortez, Ambar, Alvear, Jimena, Acuna, Carlos, Diaz, Franco, Jose Nunez, Maria, Wegner Araya, Adriana, Godoy Mundaca, Loreto, Chen, Yang, Perez Lozano, German, Pardo Carrero, Rosalba, Lopez Alarcon, Yurika Paola, Mazzillo Vega, Liliana, Maria Izquierdo, Ledys, Piñeres Olave, Byron Enrique, Zuluaga Orrego, Cesar, Quinonez Lopez, Deyanira, Vasquez Hoyos, Pablo, Vavrina, Martin, Zurek, Jiri, Campos-Miño, Santiago, Yerovi, Rocio, Bridier, Armelle, Payen, Valerie, Milesi, Christophe, Bourgoin, Pierre, Travert, Brendan, Genuini, Mathieu, Starck, Julie, Maria, Matthieu, Guichoux, Julie, Baudin, Florent, Briassoulis, George, Ilia, Stavroula, Di Nardo, Matteo, Camporesi, Anna, Chiusolo, Fabrizio, Shime, Nobuaki, Ohshimo, Shinichiro, Kida, Yoshiko, Kyo, Michihito, Tabata, Yuichi, Fong Tang, Swee, Wern Tai, Chian, See Lum, Lucy Chai, Elghuwael, Ismail, Jimenez Rivera, Nestor Javier, Jarillo Quijada, Alberto E, Kneyber, Martin, Dijkstra, Sandra, Beca, John, Sherring, Claire, Miriam, Rea, Vargas G, Sonia I, Vasquez Miranda, Daniel, Ramirez Cortez, Grimaldo, Tantalean, Jose, Pagowska-Klimek, Izabela, Gil Escobar, Carlos, Sousa Moniz, Marta, Camilo, Cristina, Hazwani, Tarek, Aldairi, Nedaa, Al Amoudi, Ahmed, Alahmadti, Ahmad, Taylor, Ryan, Mendizabal, Mikel, Goni Orayen, Concepcion, Lopez Fernandez, Yolanda, Ramon Valle, Juan, Martinez, Lidia, Pilar Orive, Javier, Brezmes, Marta, Lopez-Herce, Jesus, Parrilla, Julio, Gaboli, Mirella, Gonzalez Gomez, Jose Manuel, Morales Martinez, Antonio, Alapont, Vicent Modesto I, Sanchez Diaz, Juan Ignacio, Llorente de la Fuente, Ana M., Palanca Arias, Daniel, Madurga Revilla, Paula, Martinez de Azagra, Amelia, Garcia Gonzalez, Maria, Arjona Villanueva, David, Garcia Casas, Paula, Brio Sanagustin, Sonia, Pons Odena, Marti, Medina, Alberto, Onate Vergara, Eider, Rodriguez Campoy, Patricia, Reyes Dominguez, Susana, Dursun, Oguz, Atike Ongun, Ebru, Kamit Can, Fulya, Berna Anil, Ayse, Baines, Paul, Walsh, Laura, Jones, Dawn, Sadasivam, Kalaimaran, Mildner, Reinout, Plunkett, Adrian, Lillie, Jon, Tibby, Shane, Wellman, Paul, Belfield, Holly, Brierley, Joe, Dominguez, Troy E., Abaleke, Eugenia, Feinstein, Yael, Deep, Akash, Sundararajan, Santosh, Oruganti, Siva, Silvestre, Catarina, Weitz, James, Sheward, Victoria, Macrae, Duncan, Aramburo, Angela, Fortune, Peter-Marc, Subramanian, Gayathri, Jennings, Claire, Dwarakanathan, Buvana, Inwald, David, Feather, Calandra, Agbeko, Rachel, Lawton-Woodhall, Angela, McIntyre, Karen, Sykes, Kim, Pappachan, Jon, Gale, Helen, Mellish, Christie, McCorkell, Jenni, Torero, Luis, Nofziger, Ryan, Latifi, Samir, Anthony, Heather, Sanders, Ron, Hefley, Glenda, Virk, Manpreet, Jaimon, Nancy, Maddux, Aline B., Mourani, Peter M., Ralston, Kimberly, Sierra, Yamila, Khemani, Robinder, Newth, Christopher, Bhalla, Anoopindar, Kwok, Jeni, Morzov, Rica, Mahapatra, Sidharth, Truemper, Edward, Kustka, Lucinda, Nett, Sholeen T., Singleton, Marcy, Dean Jarvis, J., Yehya, Nadir, Napolitano, Natalie, Murphy, Marie, Ronan, Laurie, Morgan, Ryan, Kubis, Sherri, Broden, Elizabeth, Willson, Douglas, Henderson, Grace, Gedeit, Rainer, Murkowski, Kathy, Woods, Katherine, Kasch, Mary, Han, Yong Y, Affolter, Jeremy T, Tieves, Kelly S, Hughes-Schalk, Amber, Chima, Ranjit S., Krallman, Kelli, Stoneman, Erin, Benken, Laura, Yunger, Toni, Schneider, James, Sweberg, Todd, Kessel, Aaron, Carroll, Christopher L., Santanelli, James, Ackerman, Kate G, Cullimore, Melissa, Rowan, Courtney, Bales, Melissa, Keith Dockery, W., Jafari-Namin, Shirin, Barry, Dana, Jane’t, Keary, Alibrahim, Omar, Patankar, Nikhil, Qiao, Haiping, Gertz, Shira, Su, Felice, Haileselassie, Bereketeab, Song, Hanqiu, Bysani, Kris, Monjure, Tracey, Beltramo, Fernando, Totapally, Balagangadhar, Govantes, Beatriz, Coates, Bria, Wellisch, Lawren, Allen, Kiona, Shukla, Avani, Thomas, Neal J., Spear, Debbie, Shein, Steven L., Gertz, Shira, Parker, Margaret M., Sloniewsky, Daniel, Allen, Christine, Harrell, Amy, Pinto, Neethi, Kniola, Allison, Rodgers, Chiara, Cvijanovich, Natalie, Typpo, Katri, Kelley, Connor, King, Caroline, Sapru, Anil, Ratiu, Anna, Ashtari, Neda, Sikora, Lindsay, Jeyapalan, Asumthia S., Coronado-Munoz, Alvaro, Flori, Heidi, Dahmer, Mary K., Jayachandran, Chaandini, Hume, Janet, Nerheim, Dan, Smith, Rebecca, Spaeder, Michael, Adu-Darko, Michelle, Smith, Lincoln, Hartmann, Silvia, Sullivan, Erin, Merritt, Courtney, Al-Subu, Awni, Blom, Andrea, Lin, John C., Spinella, Philip, Hsing, Deyin D., Pon, Steve, Brian Estil, Jim, Gautam, Richa, Giuliano, John S., Jr, and Tala, Joana

Published
2024
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28. Segmental analysis of cardiac metabolism by hyperpolarized [1-13C] pyruvate: an in-vivo 3D MRI study in pigs

Author

Positano Vincenzo, Santarelli Maria, Frijia Francesca, Aquaro Giovanni, Menichetti Luca, Lionetti Vincenzo, Bianchi Giacomo, Flori Alessandra, Ardenkjaer-Larsen Jan, Wiesinger Florian, Schulte Rolf F, Giovannetti Giulio, Recchia Fabio A, Landini Luigi, and Lombardi Massimo

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Published
2012
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30. Detection of 3D Cardiac metabolism after injection of hyperpolarized [1-13C]pyruvate

Author

Landini Luigi, Flori Alessandra, De Marchi Daniele, Lionetti Vincenzo, Aquaro Giovanni, Bianchi Giacomo, Giovannetti Giulio, Menichetti Luca, Schulte Rolf, Ardenkjaer-Larsen Jan, Positano Vincenzo, Santarelli Maria, Wiesinger Florian, Frijia Francesca, Recchia Fabio, and Lombardi Massimo

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Published
2011
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31. Effects of mobility restrictions during COVID19 in Italy

Author

Smolyak, Alex, Bonaccorsi, Giovanni, Flori, Andrea, Pammolli, Fabio, and Havlin, Shlomo

Subjects
Physics - Physics and Society
Abstract

To reduce the spread and the effect of the COVID-19 global pandemic, non-pharmaceutical interventions (NPIs) have been adopted on multiple occasions by governments. In particular lockdown policies, i.e., generalized mobility restrictions, have been employed to fight the first wave of the pandemic. We analyze data reflecting mobility levels over time in Italy before, during and after the national lockdown, in order to assess some direct and indirect effects. By applying methodologies based on percolation and network science approaches, we find that the typical network characteristics, while very revealing, do not tell the whole story. In particular, the Italian mobility network during lockdown has been damaged much more than node- and edge-level metrics indicate. Additionally, many of the main Provinces of Italy are affected by the lockdown in a surprisingly similar fashion, despite their geographical and economic dissimilarity. Based on our findings we offer an approach to estimate unavailable high-resolution economic dimensions, such as real time Province-level GDP, based on easily measurable mobility information., Comment: 15 pages, 8 figures

Published
2021

36. Light-independent regulation of algal photoprotection by CO2 availability

Author

Ruiz-Sola, M. Águila, Flori, Serena, Yuan, Yizhong, Villain, Gaelle, Sanz-Luque, Emanuel, Redekop, Petra, Tokutsu, Ryutaro, Küken, Anika, Tsichla, Angeliki, Kepesidis, Georgios, Allorent, Guillaume, Arend, Marius, Iacono, Fabrizio, Finazzi, Giovanni, Hippler, Michael, Nikoloski, Zoran, Minagawa, Jun, Grossman, Arthur R., and Petroutsos, Dimitris

Published
2023
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37. Movement and health beyond care, MoviS: study protocol for a randomized clinical trial on nutrition and exercise educational programs for breast cancer survivors

Author

Natalucci, Valentina, Ferri Marini, Carlo, De Santi, Mauro, Annibalini, Giosuè, Lucertini, Francesco, Vallorani, Luciana, Panico, Andrea Rocco, Sisti, Davide, Saltarelli, Roberta, Donati Zeppa, Sabrina, Agostini, Deborah, Gervasi, Marco, Baldelli, Giulia, Grassi, Eugenio, Nart, Alessandra, Rossato, Massimo, Biancalana, Vincenzo, Piccoli, Giovanni, Benelli, Piero, Villarini, Anna, Somaini, Matteo, Catalano, Vincenzo, Guarino, Stefania, Pietrelli, Alice, Monaldi, Silvia, Sarti, Donatella, Barocci, Simone, Flori, Marco, Rocchi, Marco Bruno Luigi, Brandi, Giorgio, Stocchi, Vilberto, Emili, Rita, and Barbieri, Elena

Published
2023
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38. Identification of phenotypes in paediatric patients with acute respiratory distress syndrome: a latent class analysis

Author

Dahmer, Mary K, Yang, Guangyu, Zhang, Min, Quasney, Michael W, Sapru, Anil, Weeks, Heidi M, Sinha, Pratik, Curley, Martha AQ, Delucchi, Kevin L, Calfee, Carolyn S, Flori, Heidi, investigators, RESTORE and BALI study, Matthay, Michael A, Bateman, Scot T, Berg, Marc D, Borasino, Santiago, Bysani, Gokul K, Cowl, Allison S, Bowens, Cindy D, Faustino, Vincent S, Fineman, Lori D, Godshall, Aaron J, Hirshberg, Eliotte L, Kirby, Aileen L, McLaughlin, Gwenn E, Medar, Shivanand S, Oren, Phineas P, Schneider, James B, Schwarz, Adam J, Shanley, Thomas P, Source, Lauren R, Truemper, Edward J, Heyden, Michele A Vender, Wittmayer, Kimberly, Zuppa, Athena F, Wypij, David, and Network, Pediatric Acute Lung Injury and Sepsis Investigators

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Orphan Drug, Clinical Research, Rare Diseases, Acute Respiratory Distress Syndrome, Lung, 2.1 Biological and endogenous factors, Aetiology, Respiratory, Area Under Curve, Child, Humans, Latent Class Analysis, Phenotype, Respiration, Artificial, Respiratory Distress Syndrome, RESTORE and BALI study investigators, Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, Public Health and Health Services, Other Medical and Health Sciences, Cardiovascular medicine and haematology, Clinical sciences
Abstract

BackgroundPrevious latent class analysis of adults with acute respiratory distress syndrome (ARDS) identified two phenotypes, distinguished by the degree of inflammation. We aimed to identify phenotypes in children with ARDS in whom developmental differences might be important, using a latent class analysis approach similar to that used in adults.MethodsThis study was a secondary analysis of data aggregated from the Randomized Evaluation of Sedation Titration for Respiratory Failure (RESTORE) clinical trial and the Genetic Variation and Biomarkers in Children with Acute Lung Injury (BALI) ancillary study. We used latent class analysis, which included demographic, clinical, and plasma biomarker variables, to identify paediatric ARDS (PARDS) phenotypes within a cohort of children included in the RESTORE and BALI studies. The association of phenotypes with clinically relevant outcomes and the performance of paediatric data in adult ARDS classification algorithms were also assessed.Findings304 children with PARDS were included in this secondary analysis. Using latent class analysis, a two-class model was a better fit for the cohort than a one-class model (p

Published
2022

39. Effectiveness of Maternal Vaccination with mRNA COVID-19 Vaccine During Pregnancy Against COVID-19-Associated Hospitalization in Infants Aged <6 Months - 17 States, July 2021-January 2022.

Author

Halasa, Natasha, Olson, Samantha, Staat, Mary, Newhams, Margaret, Price, Ashley, Boom, Julie, Sahni, Leila, Cameron, Melissa, Pannaraj, Pia, Bline, Katherine, Bhumbra, Samina, Bradford, Tamara, Chiotos, Kathleen, Coates, Bria, Cullimore, Melissa, Cvijanovich, Natalie, Flori, Heidi, Gertz, Shira, Heidemann, Sabrina, Hobbs, Charlotte, Hume, Janet, Irby, Katherine, Kamidani, Satoshi, Kong, Michele, Levy, Emily, Mack, Elizabeth, Maddux, Aline, Michelson, Kelly, Nofziger, Ryan, Schuster, Jennifer, Schwartz, Stephanie, Smallcomb, Laura, Tarquinio, Keiko, Walker, Tracie, Zinter, Matt, Gilboa, Suzanne, Polen, Kara, Campbell, Angela, Randolph, Adrienne, and Patel, Manish

Subjects
COVID-19, COVID-19 Vaccines, Case-Control Studies, Female, Hospitalization, Hospitals, Pediatric, Humans, Immunity, Maternally-Acquired, Immunization, Passive, Infant, Infant, Newborn, Pregnancy, SARS-CoV-2, United States, Vaccines, Synthetic, mRNA Vaccines
Abstract

COVID-19 vaccination is recommended for persons who are pregnant, breastfeeding, trying to get pregnant now, or who might become pregnant in the future, to protect them from COVID-19.§ Infants are at risk for life-threatening complications from COVID-19, including acute respiratory failure (1). Evidence from other vaccine-preventable diseases suggests that maternal immunization can provide protection to infants, especially during the high-risk first 6 months of life, through passive transplacental antibody transfer (2). Recent studies of COVID-19 vaccination during pregnancy suggest the possibility of transplacental transfer of SARS-CoV-2-specific antibodies that might provide protection to infants (3-5); however, no epidemiologic evidence currently exists for the protective benefits of maternal immunization during pregnancy against COVID-19 in infants. The Overcoming COVID-19 network conducted a test-negative, case-control study at 20 pediatric hospitals in 17 states during July 1, 2021-January 17, 2022, to assess effectiveness of maternal completion of a 2-dose primary mRNA COVID-19 vaccination series during pregnancy against COVID-19 hospitalization in infants. Among 379 hospitalized infants aged

Published
2022

40. Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C

Author

Tang, Juanjie, Novak, Tanya, Hecker, Julian, Grubbs, Gabrielle, Zahra, Fatema Tuz, Bellusci, Lorenza, Pourhashemi, Sara, Chou, Janet, Moffitt, Kristin, Halasa, Natasha B, Schwartz, Stephanie P, Walker, Tracie C, Tarquinio, Keiko M, Zinter, Matt S, Staat, Mary A, Gertz, Shira J, Cvijanovich, Natalie Z, Schuster, Jennifer E, Loftis, Laura L, Coates, Bria M, Mack, Elizabeth H, Irby, Katherine, Fitzgerald, Julie C, Rowan, Courtney M, Kong, Michele, Flori, Heidi R, Maddux, Aline B, Shein, Steven L, Crandall, Hillary, Hume, Janet R, Hobbs, Charlotte V, Tremoulet, Adriana H, Shimizu, Chisato, Burns, Jane C, Chen, Sabrina R, Moon, Hye Kyung, Lange, Christoph, Randolph, Adrienne G, and Khurana, Surender

Subjects
Pediatric, Pneumonia, Emerging Infectious Diseases, Infectious Diseases, Biodefense, Immunization, Prevention, Vaccine Related, Lung, Clinical Research, Good Health and Well Being, Adolescent, Antibodies, Viral, COVID-19, Child, Child, Preschool, Humans, Membrane Glycoproteins, Neutralization Tests, SARS-CoV-2, Spike Glycoprotein, Coronavirus, Systemic Inflammatory Response Syndrome, Viral Envelope Proteins
Abstract

Neutralization capacity of antibodies against Omicron after a prior SARS-CoV-2 infection in children and adolescents is not well studied. Therefore, we evaluated virus-neutralizing capacity against SARS-CoV-2 Alpha, Beta, Gamma, Delta and Omicron variants by age-stratified analyses (5 years of age. As expected, convalescent pediatric COVID-19 and MIS-C cohorts demonstrate higher neutralization titers than hospitalized acute COVID-19 patients. Overall, children and adolescents show some loss of cross-neutralization against all variants, with the most pronounced loss against Omicron. In contrast to SARS-CoV-2 infection, children vaccinated twice demonstrated higher titers against Alpha, Beta, Gamma, Delta and Omicron. These findings can influence transmission, re-infection and the clinical disease outcome from emerging SARS-CoV-2 variants and supports the need for vaccination in children.

Published
2022

42. Spread of Perturbations in Supply Chain Networks: The Effect of the Bow-Tie Organization on the Resilience of the Global Automotive System

Author

Flori, Elisa, Zhu, Yi, Paterlini, Sandra, Pattarin, Francesco, Villani, Marco, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, De Stefano, Claudio, editor, Fontanella, Francesco, editor, and Vanneschi, Leonardo, editor

Published
2023
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48. Adverse Tracheal Intubation Events in Critically Ill Underweight and Obese Children: Retrospective Study of the National Emergency Airway for Children Registry (2013–2020)

Author

Gladen, Kelsey M., Tellez, David, Napolitano, Natalie, Edwards, Lauren R., Sanders, Ronald C., Jr, Kojima, Taiki, Malone, Matthew P., Shults, Justine, Krawiec, Conrad, Ambati, Shashikanth, McCarthy, Riley, Branca, Aline, Polikoff, Lee A., Jung, Philipp, Parsons, Simon J., Mallory, Palen, Komeswaran, Kavipriya, Page-Goertz, Christopher, Toal, Megan C., Bysani, G. Kris, Meyer, Keith, Chiusolo, Fabrizio, Glater-Welt, Lily B., Al-Subu, Awni, Biagas, Katherine, Hau Lee, Jan, Miksa, Michael, Giuliano, John S., Jr, Kierys, Krista L., Talukdar, Andrea M., DeRusso, Michelle, Cucharme-Crevier, Laurence, Adu-Arko, Michelle, Shenoi, Asha, Kimura, Dai, Flottman, Molly, Gangu, Shantaveer, Freeman, Ashley D., Piehl, Mark D., Nuthall, G. A., Tarquinio, Keiko M., Harwayne-Gidansky, Ilana, Hasegawa, Tatsuya, Rescoe, Erin S., Breuer, Ryan K., Kasagi, Mioko, Nadkarni, Vinay M., Nishisaki, Akira, Flori, Heidi, Thomas, Neal, Agus, Michael, Dahmer, Mary, Goertzen, Lexie, Khemani, Robinder, Pinto, Neethi, Faustino, Vincent, Brown, Ann-Marie, Prieto, Monica, Wing, Robyn, and Buffman, Hayley

Published
2023
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50. Evidence of economic segregation from mobility lockdown during COVID-19 epidemic

Author

Bonaccorsi, Giovanni, Pierri, Francesco, Cinelli, Matteo, Porcelli, Francesco, Galeazzi, Alessandro, Flori, Andrea, Schmidt, Ana Lucia, Valensise, Carlo Michele, Scala, Antonio, Quattrociocchi, Walter, and Pammolli, Fabio

Subjects
Physics - Physics and Society, Computer Science - Social and Information Networks
Abstract

In response to the COVID-19 pandemic, National governments have applied lockdown restrictions to reduce the infection rate. We perform a massive analysis on near real-time Italian data provided by Facebook to investigate how lockdown strategies affect economic conditions of individuals and local governments. We model the change in mobility as an exogenous shock similar to a natural disaster. We identify two ways through which mobility restrictions affect Italian citizens. First, we find that the impact of lockdown is stronger in municipalities with higher fiscal capacity. Second, we find a segregation effect, since mobility restrictions are stronger in municipalities for which inequality is higher and where individuals have lower income per capita.

Published
2020
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