9 results on '"Folawiyo O"'
Search Results
2. 33385 A polymeric emulsion of halobetasol propionate and tazarotene in the treatment of palmoplantar psoriasis
- Author
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Caroline R. Campbell, Folawiyo O. Babalola, and Jenna E. Yousif
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Dermatology - Published
- 2022
3. Cannabis use among adolescents and young adults during the COVID-19 pandemic: A systematic review
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Yuni Tang, Brenna Kirk, Folawiyo Olanrewaju, Christiaan G. Abildso, Erin L. Winstanley, Christa L. Lilly, and Toni M. Rudisill
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Adolescents ,Young adults ,COVID-19 ,Cannabis use ,Systematic Review ,Medicine - Abstract
Background: A systematic review of the literature was performed to summarize cannabis use among adolescents and young adults during the COVID-19 pandemic. Special focus was given to the prevalence of cannabis use during COVID-19, as well as factors that may explain changes in cannabis consumption patterns. Methods: The protocol of this systematic review was registered. Articles from seven publication databases were searched in January 2022. The inclusion criteria for studies were as follows: 1) published in English; 2) study instruments needed to include items on COVID-19; 3) conducted after January 1st, 2020; 4) published in a peer-reviewed journal, dissertation, or thesis; 5) study population ≤25 years of age; 6) study designs were limited to observational analytical studies; 7) measured cannabis use. This review excluded other reviews, editorials, and conference abstracts that were not available as full text manuscripts. Independent review, risk of bias assessment, and data abstraction were performed by two authors. Results: Fifteen articles from the United States (n=11) and Canada (n=4) were included in this review. The findings of this review showed that the prevalence of cannabis use during the pandemic among adolescents and young adults were mixed. Some mental health symptoms, including depression and anxiety, were identified as the most commonly reported reasons for increased cannabis use during the pandemic. Conclusions: This review highlights the inconsistencies in the prevalence of cannabis use among adolescents and young adults during the pandemic. Therapeutic interventions for mental health and continued public health surveillance should be conducted to understand the long-term effects of cannabis use among adolescents and young adults.
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- 2024
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4. 16S rRNA amplicon sequencing identifies microbiota associated with oral cancer, Human Papilloma Virus infection and surgical treatment
- Author
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Guerrero-Preston, R., primary, Godoy-Vitorino, F., additional, Jedlicka, A., additional, Rodriguez, A., additional, González, H., additional, Bondy, J., additional, Lawson, F., additional, Folawiyo, O., additional, Michailidi, M., additional, Dziedzic, A., additional, Thangavel, R., additional, Hadar, T., additional, Noordhuis, M.G., additional, Westra, W., additional, Koch, W., additional, and Sidransky, D., additional
- Published
- 2016
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5. Promoter DNA methylation patterns in oral, laryngeal and oropharyngeal anatomical regions are associated with tumor differentiation, nodal involvement and survival.
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Rivera-Peña B, Folawiyo O, Turaga N, Rodríguez-Benítez RJ, Felici ME, Aponte-Ortiz JA, Pirini F, Rodríguez-Torres S, Vázquez R, López R, Sidransky D, Guerrero-Preston R, and Báez A
- Abstract
Differentially methylated regions (DMRs) can be used as head and neck squamous cell carcinoma (HNSCC) diagnostic, prognostic and therapeutic targets in precision medicine workflows. DNA from 21 HNSCC and 10 healthy oral tissue samples was hybridized to a genome-wide tiling array to identify DMRs in a discovery cohort. Downstream analyses identified differences in promoter DNA methylation patterns in oral, laryngeal and oropharyngeal anatomical regions associated with tumor differentiation, nodal involvement and survival. Genome-wide DMR analysis showed 2,565 DMRs common to the three subsites. A total of 738 DMRs were unique to laryngeal cancer (n=7), 889 DMRs were unique to oral cavity cancer (n=10) and 363 DMRs were unique to pharyngeal cancer (n=6). Based on the genome-wide analysis and a Gene Ontology analysis, 10 candidate genes were selected to test for prognostic value and association with clinicopathological features. TIMP3 was associated with tumor differentiation in oral cavity cancer (P=0.039), DAPK1 was associated with nodal involvement in pharyngeal cancer (P=0.017) and PAX1 was associated with tumor differentiation in laryngeal cancer (P=0.040). A total of five candidate genes were selected, DAPK1, CDH1, PAX1, CALCA and TIMP3 , for a prevalence study in a larger validation cohort: Oral cavity cancer samples (n=42), pharyngeal cancer tissues (n=25) and laryngeal cancer samples (n=52). PAX1 hypermethylation differed across HNSCC anatomic subsites (P = 0.029), and was predominantly detected in laryngeal cancer. Kaplan-Meier survival analysis (P=0.043) and Cox regression analysis of overall survival (P=0.001) showed that DAPK1 methylation is associated with better prognosis in HNSCC. The findings of the present study showed that the HNSCC subsites oral cavity, pharynx and larynx display substantial differences in aberrant DNA methylation patterns, which may serve as prognostic biomarkers and therapeutic targets., Competing Interests: The authors declare that they have no competing interests., (Copyright: © Rivera-Peña et al.)
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- 2024
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6. HIST1H2BB and MAGI2 Methylation and Somatic Mutations as Precision Medicine Biomarkers for Diagnosis and Prognosis of High-grade Serous Ovarian Cancer.
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Valle BL, Rodriguez-Torres S, Kuhn E, Díaz-Montes T, Parrilla-Castellar E, Lawson FP, Folawiyo O, Ili-Gangas C, Brebi-Mieville P, Eshleman JR, Herman J, Shih IM, Sidransky D, and Guerrero-Preston R
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- Cell Line, Tumor, Cohort Studies, Cystadenocarcinoma, Serous drug therapy, Cystadenocarcinoma, Serous genetics, Cystadenocarcinoma, Serous mortality, DNA Methylation drug effects, Decitabine pharmacology, Decitabine therapeutic use, Down-Regulation, Epithelium, Fallopian Tubes pathology, Female, Gene Expression Regulation, Neoplastic drug effects, Humans, Hydroxamic Acids pharmacology, Hydroxamic Acids therapeutic use, Mutation, Ovarian Neoplasms drug therapy, Ovarian Neoplasms genetics, Ovarian Neoplasms mortality, Ovary pathology, Precision Medicine methods, Promoter Regions, Genetic, Survival Analysis, Adaptor Proteins, Signal Transducing genetics, Biomarkers, Tumor genetics, Cystadenocarcinoma, Serous diagnosis, Guanylate Kinases genetics, Histones genetics, Ovarian Neoplasms diagnosis
- Abstract
Molecular alterations that contribute to long-term (LT) and short-term (ST) survival in ovarian high-grade serous carcinoma (HGSC) may be used as precision medicine biomarkers. DNA promoter methylation is an early event in tumorigenesis, which can be detected in blood and urine, making it a feasible companion biomarker to somatic mutations for early detection and targeted treatment workflows. We compared the methylation profile in 12 HGSC tissue samples to 30 fallopian tube epithelium samples, using the Infinium Human Methylation 450K Array. We also used 450K methylation arrays to compare methylation among HGSCs long-term survivors (more than 5 years) and short-term survivors (less than 3 years). We verified the array results using bisulfite sequencing and methylation-specific PCR (qMSP). in another cohort of HGSC patient samples ( n = 35). Immunoblot and clonogenic assays after pharmacologic unmasking show that HIST1H2BB and MAGI2 promoter methylation downregulates mRNA expression levels in ovarian cancer cells. We then used qMSP in paired tissue, ascites, plasma/serum, vaginal swabs, and urine from a third cohort of patients with HGSC cancer ( n = 85) to test the clinical potential of HIST1H2BB and MAGI2 in precision medicine workflows. We also performed next-generation exome sequencing of 50 frequently mutated in human cancer genes, using the Ion AmpliSeqCancer Hotspot Panel, to show that the somatic mutation profile found in tissue and plasma can be quantified in paired urine samples from patients with HGSC. Our results suggest that HIST1H2BB and MAGI2 have growth-suppressing roles and can be used as HGSC precision medicine biomarkers., (©2020 American Association for Cancer Research.)
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- 2020
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7. JAK3 Variant, Immune Signatures, DNA Methylation, and Social Determinants Linked to Survival Racial Disparities in Head and Neck Cancer Patients.
- Author
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Guerrero-Preston R, Lawson F, Rodriguez-Torres S, Noordhuis MG, Pirini F, Manuel L, Valle BL, Hadar T, Rivera B, Folawiyo O, Baez A, Marchionni L, Koch WM, Westra WH, Kim YJ, Eshleman JR, and Sidransky D
- Subjects
- Adult, Black or African American statistics & numerical data, Biomarkers, Tumor analysis, Case-Control Studies, Female, Follow-Up Studies, Gene Expression Regulation, Neoplastic, Head and Neck Neoplasms ethnology, Head and Neck Neoplasms genetics, Head and Neck Neoplasms immunology, Humans, Male, Middle Aged, Prognosis, Squamous Cell Carcinoma of Head and Neck ethnology, Squamous Cell Carcinoma of Head and Neck genetics, Squamous Cell Carcinoma of Head and Neck immunology, Squamous Cell Carcinoma of Head and Neck mortality, Survival Rate, Tumor Suppressor Protein p53 genetics, White People statistics & numerical data, DNA Methylation, Germ-Line Mutation, Head and Neck Neoplasms mortality, Health Status Disparities, Janus Kinase 3 genetics, Lymphocytes, Tumor-Infiltrating immunology, Social Determinants of Health
- Abstract
To inform novel personalized medicine approaches for race and socioeconomic disparities in head and neck cancer, we examined germline and somatic mutations, immune signatures, and epigenetic alterations linked to neighborhood determinants of health in Black and non-Latino White (NLW) patients with head and neck cancer. Cox proportional hazards revealed that Black patients with squamous cell carcinoma of head and neck (HNSCC) with PAX5 ( P = 0.06) and PAX1 ( P = 0.017) promoter methylation had worse survival than NLW patients, after controlling for education, zipcode, and tumor-node-metastasis stage ( n = 118). We also found that promoter methylation of PAX1 and P AX5 ( n = 78), was correlated with neighborhood characteristics at the zip-code level ( P < 0.05). Analyses also showed differences in the frequency of TP53 mutations ( n = 32) and tumor-infiltrating lymphocyte (TIL) counts ( n = 24), and the presence of a specific C → A germline mutation in JAK3 , chr19:17954215 (protein P132T), in Black patients with HNSCC ( n = 73; P < 0.05), when compared with NLW ( n = 37) patients. TIL counts are associated ( P = 0.035) with long-term (>5 years), when compared with short-term survival (<2 years). We show bio-social determinants of health associated with survival in Black patients with HNSCC, which together with racial differences shown in germline mutations, somatic mutations, and TIL counts, suggests that contextual factors may significantly inform precision oncology services for diverse populations., (©2019 American Association for Cancer Research.)
- Published
- 2019
- Full Text
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8. Molecular Triage of Premalignant Lesions in Liquid-Based Cervical Cytology and Circulating Cell-Free DNA from Urine, Using a Panel of Methylated Human Papilloma Virus and Host Genes.
- Author
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Guerrero-Preston R, Valle BL, Jedlicka A, Turaga N, Folawiyo O, Pirini F, Lawson F, Vergura A, Noordhuis M, Dziedzic A, Pérez G, Renehan M, Guerrero-Diaz C, De Jesus Rodríguez E, Diaz-Montes T, Rodríguez Orengo J, Méndez K, Romaguera J, Trock BJ, Florea L, and Sidransky D
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- Adolescent, Adult, Aged, Aged, 80 and over, Biopsy, Cohort Studies, Colposcopy, DNA, Viral genetics, DNA, Viral urine, DNA-Binding Proteins genetics, Female, Human Papillomavirus DNA Tests, Human papillomavirus 16 genetics, Humans, Middle Aged, Papillomavirus Infections blood, Papillomavirus Infections urine, Papillomavirus Infections virology, Prospective Studies, Retrospective Studies, Sensitivity and Specificity, Tacrolimus Binding Proteins genetics, Uterine Cervical Neoplasms pathology, Uterine Cervical Neoplasms virology, Vaccines, Virus-Like Particle genetics, Vaginal Smears, Wnt1 Protein genetics, Uterine Cervical Dysplasia pathology, Uterine Cervical Dysplasia virology, Biomarkers, Tumor genetics, DNA Methylation, Human papillomavirus 16 isolation & purification, Papillomavirus Infections diagnosis, Uterine Cervical Neoplasms diagnosis, Uterine Cervical Dysplasia diagnosis
- Abstract
Clinically useful molecular tools to triage women for a biopsy upon referral to colposcopy are not available. We aimed to develop a molecular panel to detect cervical intraepithelial neoplasia (CIN) grade 2 or higher lesions (CIN2
+ ) in women with abnormal cervical cytology and high-risk HPV (HPV+ ). We tested a biomarker panel in cervical epithelium DNA obtained from 211 women evaluated in a cervical cancer clinic in Chile from 2006 to 2008. Results were verified in a prospective cohort of 107 women evaluated in a high-risk clinic in Puerto Rico from 2013 to 2015. Promoter methylation of ZNF516, FKBP6, and INTS1 discriminated cervical brush samples with CIN2+ lesions from samples with no intraepithelial lesions or malignancy (NILM) with 90% sensitivity, 88.9% specificity, 0.94 area under the curve (AUC), 93.1% positive predictive value (PPV), and 84.2% negative predictive value (NPV). The panel results were verified in liquid-based cervical cytology samples from an independent cohort with 90.9% sensitivity, 60.9% specificity, 0.90 AUC, 52.6% PPV, and 93.3% NPV, after adding HPV16-L1 methylation to the panel. Next-generation sequencing results in HPV+ cultured cells, and urine circulating cell-free DNA (ccfDNA) were used to design assays that show clinical feasibility in a subset (n = 40) of paired plasma (AUC = 0.81) and urine (AUC = 0.86) ccfDNA samples obtained from the prospective cohort. Viral and host DNA methylation panels can be tested in liquid cytology and urine ccfDNA from women referred to colposcopy, to triage CIN2+ lesions for biopsy and inform personalized screening algorithms. Cancer Prev Res; 9(12); 915-24. ©2016 AACR., (©2016 American Association for Cancer Research.)- Published
- 2016
- Full Text
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9. 16S rRNA amplicon sequencing identifies microbiota associated with oral cancer, human papilloma virus infection and surgical treatment.
- Author
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Guerrero-Preston R, Godoy-Vitorino F, Jedlicka A, Rodríguez-Hilario A, González H, Bondy J, Lawson F, Folawiyo O, Michailidi C, Dziedzic A, Thangavel R, Hadar T, Noordhuis MG, Westra W, Koch W, and Sidransky D
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- Aged, Cohort Studies, Female, Gene Amplification, Head and Neck Neoplasms genetics, Head and Neck Neoplasms microbiology, Head and Neck Neoplasms surgery, Head and Neck Neoplasms virology, Humans, Longitudinal Studies, Male, Middle Aged, Papillomaviridae genetics, Papillomavirus Infections microbiology, Papillomavirus Infections pathology, Papillomavirus Infections surgery, Prognosis, Risk Factors, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell genetics, Carcinoma, Squamous Cell microbiology, Carcinoma, Squamous Cell surgery, Carcinoma, Squamous Cell virology, Microbiota genetics, Mouth Neoplasms genetics, Mouth Neoplasms microbiology, Mouth Neoplasms surgery, Mouth Neoplasms virology, Oral Surgical Procedures, Papillomavirus Infections genetics, RNA, Ribosomal, 16S genetics
- Abstract
Systemic inflammatory events and localized disease, mediated by the microbiome, may be measured in saliva as head and neck squamous cell carcinoma (HNSCC) diagnostic and prognostic biomonitors. We used a 16S rRNA V3-V5 marker gene approach to compare the saliva microbiome in DNA isolated from Oropharyngeal (OPSCC), Oral Cavity Squamous Cell Carcinoma (OCSCC) patients and normal epithelium controls, to characterize the HNSCC saliva microbiota and examine their abundance before and after surgical resection.The analyses identified a predominance of Firmicutes, Proteobacteria and Bacteroidetes, with less frequent presence of Actinobacteria and Fusobacteria before surgery. At lower taxonomic levels, the most abundant genera were Streptococcus, Prevotella, Haemophilus, Lactobacillus and Veillonella, with lower numbers of Citrobacter and Neisseraceae genus Kingella. HNSCC patients had a significant loss in richness and diversity of microbiota species (p<0.05) compared to the controls. Overall, the Operational Taxonomic Units network shows that the relative abundance of OTU's within genus Streptococcus, Dialister, and Veillonella can be used to discriminate tumor from control samples (p<0.05). Tumor samples lost Neisseria, Aggregatibacter (Proteobacteria), Haemophillus (Firmicutes) and Leptotrichia (Fusobacteria). Paired taxa within family Enterobacteriaceae, together with genus Oribacterium, distinguish OCSCC samples from OPSCC and normal samples (p<0.05). Similarly, only HPV positive samples have an abundance of genus Gemellaceae and Leuconostoc (p<0.05). Longitudinal analyses of samples taken before and after surgery, revealed a reduction in the alpha diversity measure after surgery, together with an increase of this measure in patients that recurred (p<0.05). These results suggest that microbiota may be used as HNSCC diagnostic and prognostic biomonitors., Competing Interests: The authors have no conflicts of interest with the subject matter or materials discussed in this manuscript.
- Published
- 2016
- Full Text
- View/download PDF
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