Search

Your search keyword '"Fonseca, Carmen"' showing total 370 results
Start Over Author "Fonseca, Carmen"
370 results on '"Fonseca, Carmen"'

1. Prevalence and outcomes of fear of falling in older adults with falls at the emergency department: a multicentric observational study

Author

García-Martínez, Ana, García-Rosa, Sergio, Gil-Rodrigo, Adriana, Machado, Victoria Torres, Pérez-Fonseca, Carmen, Nickel, Christian H., Artajona, Lourdes, Jacob, Javier, Llorens, Pere, Herrero, Pablo, Canadell, Naila, Rangel, Carolina, Martín-Sánchez, Francisco Javier, del Nogal, Monserrat Lázaro, and Miró, Òscar

Published
2024
Full Text
View/download PDF

2. Complement component C4 structural variation and quantitative traits contribute to sex-biased vulnerability in systemic sclerosis

Author

Kerick, Martin, Acosta-Herrera, Marialbert, Simeón-Aznar, Carmen Pilar, Callejas, José Luis, Assassi, Shervin, Proudman, Susanna M., Nikpour, Mandana, Hunzelmann, Nicolas, Moroncini, Gianluca, de Vries-Bouwstra, Jeska K., Orozco, Gisela, Barton, Anne, Herrick, Ariane L., Terao, Chikashi, Allanore, Yannick, Fonseca, Carmen, Alarcón-Riquelme, Marta Eugenia, Radstake, Timothy R. D. J., Beretta, Lorenzo, Denton, Christopher P., Mayes, Maureen D., and Martin, Javier

Published
2022
Full Text
View/download PDF

4. Respiratory syncytial virus incidence and typing in the last six seasons in the north of Spain (Asturias). Genetic characterization during the SARS‐CoV‐2 pandemic

Author

Rojo‐Alba, Susana, primary, Martínez, Zulema Pérez, additional, González‐Alba, José María, additional, Boga, José Antonio, additional, Varela, Cristina Ochoa, additional, Álvarez, Maria Agustina Alonso, additional, Fonseca, Carmen Pérez, additional, Clemente, Marta María García, additional, Rodriguez, José Gutierrez, additional, García, Estibaliz Garrido, additional, Pérez, Mercedes Rodríguez, additional, García, Santiago Melón, additional, and Álvarez‐Argüelles, Marta Elena, additional

Published
2024
Full Text
View/download PDF

5. DNA combing versus DNA spreading and the separation of sister chromatids

Author

Meroni, Alice, Wells, Sophie E., Fonseca, Carmen, Ray Chaudhuri, Arnab, Caldecott, Keith W., Vindigni, Alessandro, Meroni, Alice, Wells, Sophie E., Fonseca, Carmen, Ray Chaudhuri, Arnab, Caldecott, Keith W., and Vindigni, Alessandro

Abstract

DNA combing and DNA spreading are two central approaches for studying DNA replication fork dynamics genome-wide at single-molecule resolution by distributing labeled genomic DNA on coverslips or slides for immunodetection. Perturbations in DNA replication fork dynamics can differentially affect either leading or lagging strand synthesis, for example, in instances where replication is blocked by a lesion or obstacle on only one of the two strands. Thus, we sought to investigate whether the DNA combing and/or spreading approaches are suitable for resolving adjacent sister chromatids during DNA replication, thereby enabling the detection of DNA replication dynamics within individual nascent strands. To this end, we developed a thymidine labeling scheme that discriminates between these two possibilities. Our data suggests that DNA combing resolves sister chromatids, allowing the detection of strand-specific alterations, whereas DNA spreading typically does not. These findings have important implications when interpreting DNA replication dynamics from data obtained by these two commonly used techniques.

Published
2024

10. Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.

Author

Gorlova, Olga, Martin, Jose-Ezequiel, Rueda, Blanca, Koeleman, Bobby PC, Ying, Jun, Teruel, Maria, Diaz-Gallo, Lina-Marcela, Broen, Jasper C, Vonk, Madelon C, Simeon, Carmen P, Alizadeh, Behrooz Z, Coenen, Marieke JH, Voskuyl, Alexandre E, Schuerwegh, Annemie J, van Riel, Piet LCM, Vanthuyne, Marie, van 't Slot, Ruben, Italiaander, Annet, Ophoff, Roel A, Hunzelmann, Nicolas, Fonollosa, Vicente, Ortego-Centeno, Norberto, González-Gay, Miguel A, García-Hernández, Francisco J, González-Escribano, María F, Airo, Paolo, van Laar, Jacob, Worthington, Jane, Hesselstrand, Roger, Smith, Vanessa, de Keyser, Filip, Houssiau, Fredric, Chee, Meng May, Madhok, Rajan, Shiels, Paul G, Westhovens, Rene, Kreuter, Alexander, de Baere, Elfride, Witte, Torsten, Padyukov, Leonid, Nordin, Annika, Scorza, Raffaella, Lunardi, Claudio, Lie, Benedicte A, Hoffmann-Vold, Anna-Maria, Palm, Oyvind, García de la Peña, Paloma, Carreira, Patricia, Spanish Scleroderma Group, Varga, John, Hinchcliff, Monique, Lee, Annette T, Gourh, Pravitt, Amos, Christopher I, Wigley, Frederick M, Hummers, Laura K, Nelson, J Lee, Riemekasten, Gabriella, Herrick, Ariane, Beretta, Lorenzo, Fonseca, Carmen, Denton, Christopher P, Gregersen, Peter K, Agarwal, Sandeep, Assassi, Shervin, Tan, Filemon K, Arnett, Frank C, Radstake, Timothy RDJ, Mayes, Maureen D, and Martin, Javier

Subjects
Spanish Scleroderma Group, Humans, Scleroderma, Systemic, Genetic Predisposition to Disease, Genetic Markers, Autoantibodies, HLA Antigens, Phenotype, Polymorphism, Single Nucleotide, Alleles, Middle Aged, Female, Male, Genome-Wide Association Study, Genetic Loci, Polymorphism, Single Nucleotide, Scleroderma, Systemic, Genetics, Developmental Biology
Abstract

The aim of this study was to determine, through a genome-wide association study (GWAS), the genetic components contributing to different clinical sub-phenotypes of systemic sclerosis (SSc). We considered limited (lcSSc) and diffuse (dcSSc) cutaneous involvement, and the relationships with presence of the SSc-specific auto-antibodies, anti-centromere (ACA), and anti-topoisomerase I (ATA). Four GWAS cohorts, comprising 2,296 SSc patients and 5,171 healthy controls, were meta-analyzed looking for associations in the selected subgroups. Eighteen polymorphisms were further tested in nine independent cohorts comprising an additional 3,175 SSc patients and 4,971 controls. Conditional analysis for associated SNPs in the HLA region was performed to explore their independent association in antibody subgroups. Overall analysis showed that non-HLA polymorphism rs11642873 in IRF8 gene to be associated at GWAS level with lcSSc (P = 2.32×10(-12), OR = 0.75). Also, rs12540874 in GRB10 gene (P = 1.27 × 10(-6), OR = 1.15) and rs11047102 in SOX5 gene (P = 1.39×10(-7), OR = 1.36) showed a suggestive association with lcSSc and ACA subgroups respectively. In the HLA region, we observed highly associated allelic combinations in the HLA-DQB1 locus with ACA (P = 1.79×10(-61), OR = 2.48), in the HLA-DPA1/B1 loci with ATA (P = 4.57×10(-76), OR = 8.84), and in NOTCH4 with ACA P = 8.84×10(-21), OR = 0.55) and ATA (P = 1.14×10(-8), OR = 0.54). We have identified three new non-HLA genes (IRF8, GRB10, and SOX5) associated with SSc clinical and auto-antibody subgroups. Within the HLA region, HLA-DQB1, HLA-DPA1/B1, and NOTCH4 associations with SSc are likely confined to specific auto-antibodies. These data emphasize the differential genetic components of subphenotypes of SSc.

Published
2011

14. EUinLAC Lecture 6 Slides: Portuguese foreign policy towards Latin America: A yo-yo approach

Author

Gardini, Gian Luca (Editor) and Fonseca, Carmen

Abstract

The project “The reconfiguration of the European Union presence in Latin America and the Caribbean” (EUinLAC) was conceived and launched between 2019 and 2020. The European Union Jean Monnet programme generously financed it in 2020 and the project activities were carried out between 2020 and 2023. The project was designed to promote both research and teaching on European Union (EU)-Latin America and the Caribbean (LAC) relations. The first mission was accomplished with the publication of the volume named after the project “The Redefinition of EU presence in Latin America and the Caribbean”, which brings together 18 original contributions on the topic and was published by Peter Lang in 2023. The second objective was met by the release of this innovative open educational resource, or teaching tool, an undertaking that Friedrich-Alexander University Press enthusiastically embraced and published in full open access to reach as wide an audience as possible.

Published
2023
Full Text
View/download PDF

16. Traspasando fronteras: internacionalización de la formación en políticas europeas y gestión de conflictos internacionales desde un prisma multinacional

Author

Nieto Fernández, María Isabel, Díaz Matey, Gustavo, Fuente Casamar, Miguel Ángel de la, Segoviano Monterrubio, Soledad, Fonseca, Carmen, León Reyes, Bernardino, Nieto Fernández, María Isabel, Díaz Matey, Gustavo, Fuente Casamar, Miguel Ángel de la, Segoviano Monterrubio, Soledad, Fonseca, Carmen, and León Reyes, Bernardino

Abstract

Este proyecto está en consonancia con las necesidades detectadas por la Comisión europea y el respaldo de la Unión para que los centros de enseñanza superior, mediante el incremento de las oportunidades digitales para el profesorado y el alumnado, apuesten por cursos en línea y modelos de aprendizaje mixtos. El objetivo general del proyecto es incrementar la internacionalización de la docencia de las relaciones internacionales en tres campus: la UCM, NOVA de Lisboa y Sciences Po, de tres países España, Portugal y Francia, buscando la mejora de la calidad, la relevancia y el incremento de competitividad a través de partenariado.

Published
2023

17. La educación ambiental en las niños(as) del sexto año de vida de la primera infancia

Author

de la Torre Fonseca, Carmen Rosa, Fernández Rosado, Julio César, de la Torre Fonseca, Carmen Rosa, and Fernández Rosado, Julio César

Abstract

This research work addresses the theoretical and methodological foundations that support environmental education in preschool children. In previous research, several inadequacies in the process of environmental education in the preschool grade have been recognized, which is confirmed in the pedagogical practice of the researcher. During the research process, different methods were used, such as the analysis and critique of sources, hermeneutics, the systemic approach, observation, interview, survey and statistical-mathematical elements, which allowed the development of the research. The contribution of the work is the proposal of activities to favor environmental education in children of the sixth year of life of the Luis Saiz Monte De Oca School Center., En el presente trabajo de investigación se abordan los fundamentos teórico-metodológicos que sustentan la educación ambiental en los niños en el grado preescolar. En investigaciones realizadas se reconocen varias insuficiencias en el proceso de educación ambiental en el grado preescolar, lo cual es constatado en la práctica pedagógica por parte de la investigadora. Durante el proceso investigativo se utilizaron diferentes métodos tales como el análisis y crítica de fuentes, el hermenéutico, el enfoque sistémico, la observación, la entrevista, la encuesta y elementos del estadístico-matemático los cuales permitieron desarrollar la investigación. El aporte del trabajo es, la propuesta de actividades para favorecer la educación ambiental en las niñas y niños del sexto año de vida del Centro Escolar Luis Saiz Monte De Oca.

Published
2023

18. The Effect of Body Fat Distribution on Systemic Sclerosis

Author

Villanueva-Martin, Gonzalo, primary, Acosta-Herrera, Marialbert, additional, Kerick, Martin, additional, López-Isac, Elena, additional, Simeón, Carmen P., additional, Callejas, José L., additional, Assassi, Shervin, additional, Beretta, Lorenzo, additional, SSc Group, International, additional, (ASIG), Australian Scleroderma Interest Group, additional, Allanore, Yannick, additional, Proudman, Susanna M., additional, Nikpour, Mandana, additional, Fonseca, Carmen, additional, Denton, Christopher P., additional, Radstake, Timothy R. D. J., additional, Mayes, Maureen D., additional, Jiang, Xia, additional, Martin, Javier, additional, and Bossini-Castillo, Lara, additional

Published
2022
Full Text
View/download PDF

19. LAS PRÁCTICAS DE REFLEXIÓN GUIADAS EN UN CONTEXTO DE FORMACIÓN INICIAL DOCENTE.

Author

Ch#225;vez Rojas, Jorge Eduardo, Almuna Fern#225;ndez, Jesús Andrés, Myrna Méndez-Alarcón, Claudia, Garrido Fonseca, Carmen Gloria, and Fauré Ninñoles, Jaime

Subjects
TEACHER training, TEACHER educators, TEACHING methods, PROFESSIONAL identity, ACTIVE learning, TEACHER development
Abstract

Copyright of Perspectiva Educacional is the property of Perspectiva Educacional and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
Full Text
View/download PDF

21. The effect of body fat distribution on systemic sclerosis.

Author

Ministerio de Ciencia e Innovación (España), European Commission, Instituto de Salud Carlos III, European Science Foundation, Villanueva-Martín, Gonzalo, Acosta-Herrera, Marialbert, Kerick, Martin, López-Isac, Elena, Simeón, Carmen P., Calleja, José Luis, Assassi, Shervin, Beretta, Lorenzo, Allanore, Yannick, Proudman, Susanna, Nikpour, Mandana, Fonseca, Carmen, Denton, Christopher, Radstake, Timothy R. D. J., Mayes, Maureen D., Jiang, Xia, Martin, Javier, Bossini-Castillo, Lara, Ministerio de Ciencia e Innovación (España), European Commission, Instituto de Salud Carlos III, European Science Foundation, Villanueva-Martín, Gonzalo, Acosta-Herrera, Marialbert, Kerick, Martin, López-Isac, Elena, Simeón, Carmen P., Calleja, José Luis, Assassi, Shervin, Beretta, Lorenzo, Allanore, Yannick, Proudman, Susanna, Nikpour, Mandana, Fonseca, Carmen, Denton, Christopher, Radstake, Timothy R. D. J., Mayes, Maureen D., Jiang, Xia, Martin, Javier, and Bossini-Castillo, Lara

Abstract

Obesity contributes to a chronic proinflammatory state, which is a known risk factor to develop immune-mediated diseases. However, its role in systemic sclerosis (SSc) remains to be elucidated. Therefore, we conducted a two-sample mendelian randomization (2SMR) study to analyze the effect of three body fat distribution parameters in SSc. As instrumental variables, we used the allele effects described for single nucleotide polymorphisms (SNPs) in different genome-wide association studies (GWAS) for SSc, body mass index (BMI), waist-to-hip ratio (WHR) and WHR adjusted for BMI (WHRadjBMI). We performed local (pHESS) and genome-wide (LDSC) genetic correlation analyses between each of the traits and SSc and we applied several Mendelian randomization (MR) methods (i.e., random effects inverse-variance weight, MR-Egger regression, MR pleiotropy residual sum and outlier method and a multivariable model). Our results show no genetic correlation or causal relationship between any of these traits and SSc. Nevertheless, we observed a negative causal association between WHRadjBMI and SSc, which might be due to the effect of gastrointestinal complications suffered by the majority of SSc patients. In conclusion, reverse causality might be an especially difficult confounding factor to define the effect of obesity in the onset of SSc.

Published
2022

22. The effect of body fat distribution on systemic sclerosis.

Author

Villanueva-Martín, Gonzalo, Acosta-Herrera, Marialbert, Kerick, Martin, López-Isac, Elena, Simeón, Carmen P., Callejas, Jose Luis, Assassi, S., Beretta, Lorenzo, Allanore, Yannick, Proudman, Susan, Nikpour, M, Fonseca, Carmen, Denton, Christopher, Radstake, Timothy R. D. J., Mayes, Maureen D., Jiang, Xia, Martin, Javier, Bossini-Castillo, Lara, Villanueva-Martín, Gonzalo, Acosta-Herrera, Marialbert, Kerick, Martin, López-Isac, Elena, Simeón, Carmen P., Callejas, Jose Luis, Assassi, S., Beretta, Lorenzo, Allanore, Yannick, Proudman, Susan, Nikpour, M, Fonseca, Carmen, Denton, Christopher, Radstake, Timothy R. D. J., Mayes, Maureen D., Jiang, Xia, Martin, Javier, and Bossini-Castillo, Lara

Published
2022

24. Comprehensive analysis of the major histocompatibility complex in systemic sclerosis identifies differential HLA associations by clinical and serological subtypes

Author

Acosta-Herrera, Marialbert, Kerick, Martin, Lopéz-Isac, Elena, Assassi, Shervin, Beretta, Lorenzo, Simeón-Aznar, Carmen Pilar, Ortego-Centeno, Norberto, International SSc Group, Proudman, Susanna M, Australian Scleroderma Interest Group (ASIG), Hunzelmann, Nicolas, Moroncini, Gianluca, de Vries-Bouwstra, Jeska K, Orozco, Gisela, Barton, Anne, Herrick, Ariane L, Terao, Chikashi, Allanore, Yannick, Brown, Matthew A, Radstake, Timothy Rdj, Fonseca, Carmen, Denton, Christopher P, Mayes, Maureen D, Martin, Javier, Ministerio de Ciencia e Innovación (España), Instituto de Salud Carlos III, National Institutes of Health (US), Manchester Biomedical Research Centre, Universidad de Cantabria, Institut Català de la Salut, [Acosta-Herrera M, Kerick M, Lopéz-Isac E] Department of Cell Biology and Immunology, Institute of Parasitology and Biomedicine López-Neyra, CSIC, Granada, Andalucía, Spain. [Assassi S] Rheumatology and Clinical Immunogenetics, The University of Texas Health Science Center at Houston, Houston, Texas, USA. [Beretta L] Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy. [Simeón-Aznar CP] Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
0301 basic medicine, autoantibodies, systemic sclerosis, Immunology, Locus (genetics), Single-nucleotide polymorphism, Human leukocyte antigen, Major histocompatibility complex, General Biochemistry, Genetics and Molecular Biology, polymorphism, Major Histocompatibility Complex, 03 medical and health sciences, 0302 clinical medicine, Antígens HLA, Rheumatology, Polymorphism (computer science), Other subheadings::Other subheadings::/immunology [Other subheadings], Immunology and Allergy, Medicine, Humans, Genetic Predisposition to Disease, Otros calificadores::Otros calificadores::/inmunología [Otros calificadores], Allele, skin and connective tissue diseases, Alleles, 030203 arthritis & rheumatology, Skin and Connective Tissue Diseases::Skin and Connective Tissue Diseases::Skin Diseases::Scleroderma, Systemic [DISEASES], Scleroderma, Systemic, Amino Acids, Peptides, and Proteins::Proteins::Glycoproteins::Membrane Glycoproteins::Histocompatibility Antigens Class II [CHEMICALS AND DRUGS], biology, immune complex diseases, business.industry, enfermedades de la piel y tejido conjuntivo::enfermedades de la piel y tejido conjuntivo::enfermedades de la piel::esclerodermia sistémica [ENFERMEDADES], Autoantibody, 030104 developmental biology, biology.protein, Esclerosi sistemàtica progressiva, genetic, Immunogenètica, business, Immune complex disease, aminoácidos, péptidos y proteínas::proteínas::glicoproteínas::glicoproteínas de membranas::antígenos de histocompatibilidad de clase II [COMPUESTOS QUÍMICOS Y DROGAS], Genome-Wide Association Study, HLA-DRB1 Chains
Abstract

Objective The greatest genetic effect reported for systemic sclerosis (SSc) lies in the major histocompatibility complex (MHC) locus. Leveraging the largest SSc genome-wide association study, we aimed to fine-map this region to identify novel human leucocyte antigen (HLA) genetic variants associated with SSc susceptibility and its main clinical and serological subtypes. Methods 9095 patients with SSc and 17 584 controls genome-wide genotyped were used to impute and test single-nucleotide polymorphisms (SNPs) across the MHC, classical HLA alleles and their composite amino acid residues. Additionally, patients were stratified according to their clinical and serological status, namely, limited cutaneous systemic sclerosis (lcSSc), diffuse cutaneous systemic sclerosis (dcSSc), anticentromere (ACA), antitopoisomerase (ATA) and anti-RNApolIII autoantibodies (ARA). Results Sequential conditional analyses showed nine SNPs, nine classical alleles and seven amino acids that modelled the observed associations with SSc. This confirmed previously reported associations with HLA-DRB1*11:04 and HLA-DPB1*13:01, and revealed a novel association of HLA-B*08:01. Stratified analyses showed specific associations of HLA-DQA1*02:01 with lcSSc, and an exclusive association of HLA-DQA1*05:01 with dcSSc. Similarly, private associations were detected in HLA-DRB1*08:01 and confirmed the previously reported association of HLA-DRB1*07:01 with ACA-positive patients, as opposed to the HLA-DPA1*02:01 and HLA-DQB1*03:01 alleles associated with ATA presentation. Conclusions This study confirms the contribution of HLA class II and reveals a novel association of HLA class I with SSc, suggesting novel pathways of disease pathogenesis. Furthermore, we describe specific HLA associations with SSc clinical and serological subtypes that could serve as biomarkers of disease severity and progression., This work was supported by the Spanish Ministry of Science and Innovation (grant ref. SAF2015-66761-P and RTI20181013 (32-B-100)), Red de Investigación en Inflamación y Enfermedades Reumáticas from Instituto de Salud Carlos III (RD16/0012/0013) and grants from National Institutes of Health (R01AR073284) and DoD (W81XWH-16-1-0296). MAH was funded by the Spanish Ministry of Science and Innovation through the Juan de la Cierva Incorporacion program (ref. IJC2018-035131-I). GO, AB and ALH were supported by the NIHR Manchester Biomedical Research Centre and Versus Arthritis (grant ref 21754)

Published
2021

25. Identification of IL12RB1 as a Novel Systemic Sclerosis Susceptibility Locus

Author

López-Isac, Elena, Bossini-Castillo, Lara, Guerra, Sandra G., Denton, Christopher, Fonseca, Carmen, Assassi, Shervin, Zhou, Xiaodong, Mayes, Maureen D., Simeón, Carmen Pilar, Ortego-Centeno, Norberto, Castellví, Iván, Carreira, Patricia, Gorlova, Olga, Beretta, Lorenzo, Santaniello, Alessandro, Lunardi, Claudio, Hesselstrand, Roger, Nordin, Annika, Riemekasten, Gabriela, Witte, Torsten, Hunzelmann, Nicolas, Kreuter, Alexander, Distler, Jörg H. W., Voskuyl, Alexandre E., de Vries-Bouwstra, Jeska, Koeleman, Bobby P., Herrick, Ariane, Worthington, Jane, Radstake, Timothy R. D. J., and Martin, Javier

Published
2014
Full Text
View/download PDF

26. Surviving Older Patients Show Preserved Cellular and Humoral Immunological Memory Several Months After SARS-CoV-2 Infection

Author

García-Torre, Alejandra, primary, Bueno-García, Eva, additional, López-Martínez, Rocío, additional, Rioseras, Beatriz, additional, Moro-García, Marco Antonio, additional, Alonso-Alvarez, Sara, additional, Lluna-González, Alba, additional, Sousa-Fernández, Alejandra, additional, Fernández-Gudin, Marta, additional, Campos-Riopedre, Laura, additional, Castro-del Cueto, Corina, additional, Pérez-Fernández, Ana Belén, additional, Alonso-Rodríguez, Ana, additional, Menéndez-Peña, Carla, additional, Menéndez-Peña, Lara, additional, García-Arnaldo, Noelia, additional, Feito-Díaz, Estefanía, additional, Fernández-Lorences, Adriana, additional, Fraile-Manzano, Agustín, additional, Fernández-Iglesias, Carolina, additional, Rivera, José Arturo, additional, Pérez-Fonseca, Carmen, additional, Urdiales-Ruano, Estibaliz, additional, Debán-Fernández, María, additional, Mendes-Moreira, Hugo, additional, Herrero-Puente, Pablo, additional, and Alonso-Arias, Rebeca, additional

Published
2021
Full Text
View/download PDF

27. Supplemental Material, sj-pdf-1-ptd-10.1177_0896860820973120 - Intraperitoneal pressure: Stability over time and validation of Durand’s measurement method

Author

Sobrino-Pérez, Alicia, Pérez-Escudero, Alfonso, Fernández-Arroyo, Lucila, Dorado-García, Ana, Martín-Alcón, Berta, Gutiérrez-Martín, Carmen, Sánchez-Fonseca, Carmen, Barrios-Rebollo, Cristina, and Pérez-Díaz, Vicente

Subjects
Medicine
Abstract

Supplemental Material, sj-pdf-1-ptd-10.1177_0896860820973120 for Intraperitoneal pressure: Stability over time and validation of Durand’s measurement method by Alicia Sobrino-Pérez, Alfonso Pérez-Escudero, Lucila Fernández-Arroyo, Ana Dorado-García, Berta Martín-Alcón, Carmen Gutiérrez-Martín, Carmen Sánchez-Fonseca, Cristina Barrios-Rebollo, Vicente Pérez-Díaz and on behalf of Group PIPDPCyL in Peritoneal Dialysis International

Published
2021
Full Text
View/download PDF

28. Genomic Risk Score impact on susceptibility to systemic sclerosis

Author

Bossini-Castillo, Lara, Villanueva-Martin, Gonzalo, Kerick, Martin, Acosta-Herrera, Marialbert, Lopez-Isac, Elena, Simeon, Carmen P., Ortego-Centeno, Norberto, Assassi, Shervin, Hunzelmann, Nicolas, Gabrielli, Armando, de Vries-Bouwstra, J. K., Allanore, Yannick, Fonseca, Carmen, Denton, Christopher P., Radstake, Timothy R. D. J., Eugenia Alarcon-Riquelme, Marta, Beretta, Lorenzo, Mayes, Maureen D., Martin, Javier, Bossini-Castillo, Lara, Villanueva-Martin, Gonzalo, Kerick, Martin, Acosta-Herrera, Marialbert, Lopez-Isac, Elena, Simeon, Carmen P., Ortego-Centeno, Norberto, Assassi, Shervin, Hunzelmann, Nicolas, Gabrielli, Armando, de Vries-Bouwstra, J. K., Allanore, Yannick, Fonseca, Carmen, Denton, Christopher P., Radstake, Timothy R. D. J., Eugenia Alarcon-Riquelme, Marta, Beretta, Lorenzo, Mayes, Maureen D., and Martin, Javier

Abstract

Objectives Genomic Risk Scores (GRS) successfully demonstrated the ability of genetics to identify those individuals at high risk for complex traits including immune-mediated inflammatory diseases (IMIDs). We aimed to test the performance of GRS in the prediction of risk for systemic sclerosis (SSc) for the first time. Methods Allelic effects were obtained from the largest SSc Genome-Wide Association Study (GWAS) to date (9 095 SSc and 17 584 healthy controls with European ancestry). The best-fitting GRS was identified under the additive model in an independent cohort that comprised 400 patients with SSc and 571 controls. Additionally, GRS for clinical subtypes (limited cutaneous SSc and diffuse cutaneous SSc) and serological subtypes (anti-topoisomerase positive (ATA+) and anti-centromere positive (ACA+)) were generated. We combined the estimated GRS with demographic and immunological parameters in a multivariate generalised linear model. Results The best-fitting SSc GRS included 33 single nucleotide polymorphisms (SNPs) and discriminated between patients with SSc and controls (area under the receiver operating characteristic (ROC) curve (AUC)=0.673). Moreover, the GRS differentiated between SSc and other IMIDs, such as rheumatoid arthritis and Sjogren's syndrome. Finally, the combination of GRS with age and immune cell counts significantly increased the performance of the model (AUC=0.787). While the SSc GRS was not able to discriminate between ATA+ and ACA+ patients (AUC<0.5), the serological subtype GRS, which was based on the allelic effects observed for the comparison between ACA+ and ATA+ patients, reached an AUC=0.693. Conclusions GRS was successfully implemented in SSc. The model discriminated between patients with SSc and controls or other IMIDs, confirming the potential of GRS to support early and differential diagnosis for SSc.

Published
2021

30. Innovación y escenas pedagógicas: formadores de profesores en laboratorio de aprendizaje.

Author

Gloria Garrido-Fonseca, Carmen and Salinas-Carvajal, Danisa

Subjects
TEACHER educators, LEARNING laboratories, EDUCATIONAL innovations, SCHOOL year, GROUP process
Abstract

Copyright of Revista Colombiana de Educación is the property of Universidad Pedaggica Nacional and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022
Full Text
View/download PDF

31. New insight on the Xq28 association with systemic sclerosis

Author

Carmona, F David, Cénit, M Carmen, Diaz-Gallo, Lina-Marcela, Broen, Jasper C A, Simeón, Carmen P, Carreira, Patricia E, Callejas-Rubio, José-Luis, Fonollosa, Vicente, López-Longo, Francisco J, González-Gay, Miguel A, Hunzelmann, Nicolas, Riemekasten, Gabriela, Witte, Torsten, Kreuter, Alexander, Distler, Jörg H W, Madhok, Rajan, Shiels, Paul, van Laar, Jacob M, Schuerwegh, Annemie J, Vonk, Madelon C, Voskuyl, Alexandre E, Fonseca, Carmen, Denton, Christopher P, Herrick, Ariane, Worthington, Jane, Arnett, Frank C, Tan, Filemon K, Assassi, Shervin, Radstake, Timothy R D J, Mayes, Maureen D, and Martín, Javier

Published
2013
Full Text
View/download PDF

32. Genomic Risk Score impact on susceptibility to systemic sclerosis

Author

Bossini-Castillo, Lara, Villanueva-Martin, Gonzalo, Kerick, Martin, Acosta-Herrera, Marialbert, López-Isac, Elena, Simeón, Carmen P, Ortego-Centeno, Norberto, Assassi, Shervin, International SSc Group, Australian Scleroderma Interest Group (ASIG), PRECISESADS Clinical Consortium, PRECISESADS Flow Cytometry study group, Hunzelmann, Nicolas, Gabrielli, Armando, de Vries-Bouwstra, J K, Allanore, Yannick, Fonseca, Carmen, Denton, Christopher P, Radstake, Timothy Rdj, Alarcón-Riquelme, Marta Eugenia, Beretta, Lorenzo, Mayes, Maureen D, and Martin, Javier

Subjects
0301 basic medicine, Oncology, Male, Genome-wide association study, Arthritis, Rheumatoid, 0302 clinical medicine, Risk Factors, Immunology and Allergy, Medicine, Lupus Erythematosus, Systemic, scleroderma, skin and connective tissue diseases, Framingham Risk Score, integumentary system, Middle Aged, Sjogren's Syndrome, Rheumatoid arthritis, Antibodies, Antinuclear, Cohort, Female, Adult, medicine.medical_specialty, Immunology, Single-nucleotide polymorphism, Polymorphism, Single Nucleotide, General Biochemistry, Genetics and Molecular Biology, White People, 03 medical and health sciences, Rheumatology, Scleroderma, Limited, Internal medicine, Humans, autoimmune diseases, Genetic Predisposition to Disease, Allele, Aged, Autoantibodies, Scleroderma, Systemic, Receiver operating characteristic, immune complex diseases, business.industry, fungi, systemic, medicine.disease, 030104 developmental biology, Case-Control Studies, Scleroderma, Diffuse, Linear Models, business, 030217 neurology & neurosurgery, Immune complex disease, DNA Topoisomerases, Genome-Wide Association Study
Abstract

ObjectivesGenomic Risk Scores (GRS) successfully demonstrated the ability of genetics to identify those individuals at high risk for complex traits including immune-mediated inflammatory diseases (IMIDs). We aimed to test the performance of GRS in the prediction of risk for systemic sclerosis (SSc) for the first time.MethodsAllelic effects were obtained from the largest SSc Genome-Wide Association Study (GWAS) to date (9 095 SSc and 17 584 healthy controls with European ancestry). The best-fitting GRS was identified under the additive model in an independent cohort that comprised 400 patients with SSc and 571 controls. Additionally, GRS for clinical subtypes (limited cutaneous SSc and diffuse cutaneous SSc) and serological subtypes (anti-topoisomerase positive (ATA+) and anti-centromere positive (ACA+)) were generated. We combined the estimated GRS with demographic and immunological parameters in a multivariate generalised linear model.ResultsThe best-fitting SSc GRS included 33 single nucleotide polymorphisms (SNPs) and discriminated between patients with SSc and controls (area under the receiver operating characteristic (ROC) curve (AUC)=0.673). Moreover, the GRS differentiated between SSc and other IMIDs, such as rheumatoid arthritis and Sjögren’s syndrome. Finally, the combination of GRS with age and immune cell counts significantly increased the performance of the model (AUC=0.787). While the SSc GRS was not able to discriminate between ATA+ and ACA+ patients (AUCConclusionsGRS was successfully implemented in SSc. The model discriminated between patients with SSc and controls or other IMIDs, confirming the potential of GRS to support early and differential diagnosis for SSc.

Published
2020

33. América Latina em tempos de COVID-19

Author

Malamud, Andrés, Fonseca, Carmen, Romão, Filipe Luís de Vasconcelos, and Morriconi, Marcelo

Subjects
América Latina, COVID-19
Abstract

Integra-se num Ciclo de Conferências em parceria: IDN-ISCTE-DN N/A

Published
2020

34. Cotidianidad y producción de textos narrativos: Trabajo colaborativo para fortalecer prácticas pedagógicas en las instituciones educativas Rafael Nuñez y Soledad Acosta de Samper de Cartagena de Indias

Author

Arrieta Balvera, Yulieth Paola, Baldiris Revollo, Virginia, Padilla Fonseca, Carmen Rosa, Utria Hernández, Yuris Leandra, and Barrios Salas, Modesta (Asesora)

Subjects
Escritura - Enseñanza - Metodología, Promoción de la escritura - Metodología
Abstract

Tesis (Magister en Educación con Énfasis en Ciencias Exactas, Naturales y del Lenguaje) -- Universidad de Cartagena. Facultad de Ciencias Sociales y Educación. Maestría en Educación con Énfasis en Ciencias Exactas, Naturales y del Lenguaje, 2020 Informe de sistematización y transformación de las prácticas pedagógicas para favorecer el desarrollo de la competencia comunicativa escritora y las habilidades para la vida mediante la implementación de proyectos de aula y la incorporación de metodologías dinámicas, a través de un proyecto interinstitucional denominado cotidianidad y producción de textos narrativos, correspondientes a las instituciones educativas Soledad Acosta de Samper y Rafael Núñez de Cartagena de Indias

Published
2020

35. Supplemental Material, PVC_Durand_VPD_PDI_SupplMaterial_(1) - Intraperitoneal pressure: Stability over time and validation of Durand’s measurement method

Author

Sobrino-Pérez, Alicia, Pérez-Escudero, Alfonso, Fernández-Arroyo, Lucila, Dorado-García, Ana, Martín-Alcón, Berta, Gutiérrez-Martín, Carmen, Sánchez-Fonseca, Carmen, Barrios-Rebollo, Cristina, and Pérez-Díaz, Vicente

Subjects
Medicine
Abstract

Supplemental Material, PVC_Durand_VPD_PDI_SupplMaterial_(1) for Intraperitoneal pressure: Stability over time and validation of Durand’s measurement method by Alicia Sobrino-Pérez, Alfonso Pérez-Escudero, Lucila Fernández-Arroyo, Ana Dorado-García, Berta Martín-Alcón, Carmen Gutiérrez-Martín, Carmen Sánchez-Fonseca, Cristina Barrios-Rebollo, Vicente Pérez-Díaz and on behalf of Group PIPDPCyL in Peritoneal Dialysis International

Published
2020
Full Text
View/download PDF

36. A polymorphism in the CTGF promoter region associated with systemic sclerosis

Author

Fonseca, Carmen, Lindahl, Gisela E., Ponticos, Markella, Sestini, Piersante, Renzoni, Elisabetta A., Holmes, Alan M., Spagnolo, Paolo, Pantelidis, Panagiotis, Leoni, Patricia, McHugh, Neil, Stock, Carmel J., Xu Shi-Wen, Penton, Christopher P., Black, Carol M., Welsh, Kenneth I., du Bois, Ronald M., and Abraham, David J.

Subjects
Scleroderma (Disease) -- Research, Scleroderma (Disease) -- Genetic aspects, Scleroderma (Disease) -- Care and treatment, Systemic scleroderma -- Research, Systemic scleroderma -- Genetic aspects, Systemic scleroderma -- Care and treatment, Genetic polymorphisms -- Research, Genetic polymorphisms -- Physiological aspects, Connective tissues -- Research, Connective tissues -- Genetic aspects
Abstract

A polymorphism is genotyped in the promoter of the connective-tissue growth factor (CTGF) to study more about systemic sclerosis (scleroderma), an autoimmune disease. The results show that the polymorphism helps in the treatment of the disease by repressing the CTGF transcription.

Published
2007

37. Analysis of Anti-RNA Polymerase III Antibody-positive Systemic Sclerosis and Altered GPATCH2L and CTNND2 Expression in Scleroderma Renal Crisis

Author

Stern, E.P., Guerra, S. G., Chinque, H., Acquaah, V., González-Serna, David, Ponticos, M., Martín, J., Ong, V.H., Khan, K., Nihtyanova, S.I., Harber, M., Burns, A., Mayes, Maureen D., Assassi, S., Fonseca, Carmen, Denton, C.P., Stern, E.P., Guerra, S. G., Chinque, H., Acquaah, V., González-Serna, David, Ponticos, M., Martín, J., Ong, V.H., Khan, K., Nihtyanova, S.I., Harber, M., Burns, A., Mayes, Maureen D., Assassi, S., Fonseca, Carmen, and Denton, C.P.

Abstract

OBJECTIVE: Scleroderma renal crisis (SRC) is a life-threatening complication of systemic sclerosis (SSc) strongly associated with anti-RNA polymerase III antibody (ARA) autoantibodies. We investigated genetic susceptibility and altered protein expression in renal biopsy specimens in ARA-positive patients with SRC. METHODS: ARA-positive patients (n = 99) with at least 5 years' follow-up (49% with a history of SRC) were selected from a well characterized SSc cohort (n = 2254). Cases were genotyped using the Illumina Human Omni-express chip. Based on initial regression analysis, 9 single-nucleotide polymorphisms (SNP) were chosen for validation in a separate cohort of 256 ARA-positive patients (40 with SRC). Immunostaining of tissue sections from SRC or control kidney was used to quantify expression of candidate proteins based upon genetic analysis of the discovery cohort. RESULTS: Analysis of 641,489 SNP suggested association of POU2F1 (rs2093658; P = 1.98 × 10-5), CTNND2 (rs1859082; P = 5.58 × 10-5), HECW2 (rs16849716; P = 1.2 × 10-4), and GPATCH2L (rs935332; P = 4.92 × 10-5) with SRC. Further, the validation cohort showed an association between rs935332 within the GPATCH2L region, with SRC (P = 0.025). Immunostaining of renal biopsy sections showed increased tubular expression of GPATCH2L (P = 0.026) and glomerular expression of CTNND2 (P = 0.026) in SRC samples (n = 8) compared with normal human kidney controls (n = 8), despite absence of any genetic replication for the associated SNP. CONCLUSION: Increased expression of 2 candidate proteins, GPATCH2L and CTNND2, in SRC compared with control kidney suggests a potential role in pathogenesis of SRC. For GPATCH2L, this may reflect genetic susceptibility in ARA-positive patients with SSc based upon 2 independent cohorts.

Published
2020

39. A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci

Author

Martin, Jose-Ezequiel, Assassi, Shervin, Diaz-Gallo, Lina-Marcela, Broen, Jasper C., Simeon, Carmen P., Castellvi, Ivan, Vicente-Rabaneda, Esther, Fonollosa, Vicente, Ortego-Centeno, Norberto, González-Gay, Miguel A., Espinosa, Gerard, Carreira, Patricia, Camps, Mayte, Sabio, Jose M., Dʼalfonso, Sandra, Vonk, Madelon C., Voskuyl, Alexandre E., Schuerwegh, Annemie J., Kreuter, Alexander, Witte, Torsten, Riemekasten, Gabriella, Hunzelmann, Nicolas, Airo, Paolo, Beretta, Lorenzo, Scorza, Raffaella, Lunardi, Claudio, Van Laar, Jacob, Chee, Meng May, Worthington, Jane, Herrick, Arianne, Denton, Christopher, Fonseca, Carmen, Tan, Filemon K., Arnett, Frank, Zhou, Xiaodong, Reveille, John D., Gorlova, Olga, Koeleman, Bobby P.C., Radstake, Timothy R.D.J., Vyse, Timothy, Mayes, Maureen D., Alarcón-Riquelme, Marta E., and Martin, Javier

Published
2013
Full Text
View/download PDF

40. Implication of IL-2/IL-21 region in systemic sclerosis genetic susceptibility

Author

Diaz-Gallo, Lina-Marcela, Simeon, Carmen P, Broen, Jasper C, Ortego-Centeno, Norberto, Beretta, Lorenzo, Vonk, Madelon C, Carreira, Patricia E, Vargas, Sofia, Román-Ivorra, José Andrés, González-Gay, Miguel A, Tolosa, Carlos, López-Longo, Francisco Javier, Espinosa, Gerard, Vicente, Esther F, Hesselstrand, Roger, Riemekasten, Gabriela, Witte, Torsten, Distler, Jörg H W, Voskuyl, Alexandre E, Schuerwegh, Annemie J, Shiels, Paul G, Nordin, Annika, Padyukov, Leonid, Hoffmann-Vold, Anna-Maria, Scorza, Raffaella, Lunardi, Claudio, Airo, Paolo, van Laar, Jacob M, Hunzelmann, Nicolas, Gathof, Birgit S, Kreuter, Alexander, Herrick, Ariane, Worthington, Jane, Denton, Christopher P, Zhou, Xiaodong, Arnett, Frank C, Fonseca, Carmen, Koeleman, Bobby PC, Assasi, Shervin, Radstake, Timothy R D J, Mayes, Maureen D, Martín, Javier, Callejas, Jose Luis, Ríos, Raquel, Navarrete, Nuria, Portales, Rosa García, Camps, María Teresa, Fernández-Nebro, Antonio, González-Escribano, María F., Sánchez-Román, Julio, García-Hernández, Francisco J, Castillo, M Jesús, Aguirre, M Ángeles, Gómez-Gracia, Inmaculada, Fernández-Gutiérrez, Benjamín, Rodríguez-Rodríguez, Luis, Andreu, José Luis, de la Peña, Paloma García, Martínez, Lina, Robles, María Ángeles, Oreiro, Natividad, de Reumatología, Servicio, Fonollosa, Vicente, Pros, Anna, Carballeira, Mónica Rodríguez, Narváez, Francisco Javier, Díaz, Bernardino, Trapiella, Luis, Gallego, María, del Carmen Freire, María, Vaqueiro, Inés, Egurbide, María Victoria, Sáez-Comet, Luis, Díaz, Federico, Hernández, Vanesa, and Beltrán, Emma

Published
2013
Full Text
View/download PDF

42. Confirmation of TNIP1 but not RHOB and PSORS1C1 as systemic sclerosis risk factors in a large independent replication study

Author

Bossini-Castillo, Lara, Martin, Jose Ezequiel, Broen, Jasper, Simeon, Carmen P, Beretta, Lorenzo, Gorlova, Olga Y, Vonk, Madelon C, Ortego-Centeno, Norberto, Espinosa, Gerard, Carreira, Patricia, García de la Peña, Paloma, Oreiro, Natividad, Román-Ivorra, José Andrés, Castillo, María Jesús, González-Gay, Miguel A, Sáez-Comet, Luis, Castellví, Ivan, Schuerwegh, Annemie J, Voskuyl, Alexandre E, Hoffmann-Vold, Anna-Maria, Hesselstrand, Roger, Nordin, Annika, Lunardi, Claudio, Scorza, Raffaella, van Laar, Jacob M, Shiels, Paul G, Herrick, Ariane, Worthington, Jane, Fonseca, Carmen, Denton, Christopher, Tan, Filemon K, Arnett, Frank C, Assassi, Shervin, Koeleman, Bobby P, Mayes, Maureen D, Radstake, Timothy R D J, and Martin, Javier

Published
2013
Full Text
View/download PDF

45. Identification of CSK as a systemic sclerosis genetic risk factor through Genome Wide Association Study follow-up

Author

Martin, Jose-Ezequiel, Broen, Jasper C., Carmona, F. David, Teruel, Maria, Simeon, Carmen P., Vonk, Madelon C., van ‘t Slot, Ruben, Rodriguez-Rodriguez, Luis, Vicente, Esther, Fonollosa, Vicente, Ortego-Centeno, Norberto, González-Gay, Miguel A., García-Hernández, Francisco J., de la Peña, Paloma García, Carreira, Patricia, Voskuyl, Alexandre E., Schuerwegh, Annemie J., van Riel, Piet L.C.M., Kreuter, Alexander, Witte, Torsten, Riemekasten, Gabriella, Airo, Paolo, Scorza, Raffaella, Lunardi, Claudio, Hunzelmann, Nicolas, Distler, Jörg H.W., Beretta, Lorenzo, van Laar, Jacob, Chee, Meng May, Worthington, Jane, Herrick, Ariane, Denton, Christopher, Tan, Filemon K., Arnett, Frank C., Assassi, Shervin, Fonseca, Carmen, Mayes, Maureen D., Radstake, Timothy R.D.J., Koeleman, Bobby P.C., and Martin, Javier

Published
2012
Full Text
View/download PDF

46. A GWAS follow-up study reveals the association of the IL12RB2 gene with systemic sclerosis in Caucasian populations

Author

Bossini-Castillo, Lara, Martin, Jose-Ezequiel, Broen, Jasper, Gorlova, Olga, Simeo[Combining Acute Accent]n, Carmen P., Beretta, Lorenzo, Vonk, Madelon C., Luis Callejas, Jose, Castellví, Ivan, Carreira, Patricia, José García-Hernández, Francisco, Ferna[Combining Acute Accent]ndez Castro, Mo[Combining Acute Accent]nica, Coenen, Marieke J.H., Riemekasten, Gabriela, Witte, Torsten, Hunzelmann, Nicolas, Kreuter, Alexander, Distler, Jörg H.W., Koeleman, Bobby P., Voskuyl, Alexandre E., Schuerwegh, Annemie J., Palm, Øyvind, Hesselstrand, Roger, Nordin, Annika, Airó, Paolo, Lunardi, Claudio, Scorza, Raffaella, Shiels, Paul, van Laar, Jacob M., Herrick, Ariane, Worthington, Jane, Denton, Christopher, Tan, Filemon K., Arnett, Frank C., Agarwal, Sandeep K., Assassi, Shervin, Fonseca, Carmen, Mayes, Maureen D., Radstake, Timothy R.D.J., and Martin, Javier

Published
2012
Full Text
View/download PDF

47. Confirmation of association of the macrophage migration inhibitory factor gene with systemic sclerosis in a large European population

Author

Bossini-Castillo, Lara, Simeon, Carmen P., Beretta, Lorenzo, Vonk, Madelon C., Callejas-Rubio, José Luis, Espinosa, Gerard, Carreira, Patricia, Camps, María T., Rodríguez-Rodríguez, Luis, Rodríguez-Carballeira, Mónica, García-Hernández, Francisco J., López-Longo, Francisco J., Hernández-Hernández, Vanesa, Sáez-Comet, Luis, Egurbide, María Victoria, Hesselstrand, Roger, Nordin, Annika, Hoffmann-Vold, Anna-Maria, Vanthuyne, Marie, Smith, Vanessa, De Langhe, Ellen, Kreuter, Alexander, Riemekasten, Gabriela, Witte, Torsten, Hunzelmann, Nicolas, Voskuyl, Alexandre E., Schuerwegh, Annemie J., Lunardi, Claudio, Airó, Paolo, Scorza, Raffaella, Shiels, Paul, van Laar, Jacob M., Fonseca, Carmen, Denton, Christopher, Herrick, Ariane, Worthington, Jane, Koeleman, Bobby P., Rueda, Blanca, Radstake, Timothy R. D. J., and Martin, Javier

Published
2011
Full Text
View/download PDF

48. Association of a non-synonymous functional variant of the ITGAM gene with systemic sclerosis

Author

Carmona, F David, Simeon, Carmen P, Beretta, Lorenzo, Carreira, Patricia, Vonk, Madelon C, Ríos-Fernández, Raquel, Espinosa, Gerard, Navarrete, Nuria, Vicente-Rabaneda, Esther, Rodríguez-Rodríguez, Luis, Tolosa, Carlos, García-Hernández, Francisco J, Castellví, Iván, Egurbide, María Victoria, Fonollosa, Vicente, González-Gay, Miguel A, Rodríguez-Carballeira, Mónica, Díaz-Gónzalez, Federico, Sáez-Comet, Luis, Hesselstrand, Roger, Riemekasten, Gabriela, Witte, Torsten, Voskuyl, Alexandre E, Schuerwegh, Annemie J, Madhok, Rajan, Shiels, Paul, Fonseca, Carmen, Denton, Christopher, Nordin, Annika, Palm, Øyvind, Hoffmann-Vold, Anna-Maria, Airó, Paolo, Scorza, Raffaella, Lunardi, Claudio, van Laar, Jacob M, Hunzelmann, Nicolas, Kreuter, Alexander, Herrick, Ariane, Worthington, Jane, Koeleman, Bobby P C, Radstake, Timothy R D J, and Martín, Javier

Published
2011
Full Text
View/download PDF

49. A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort

Author

Bossini-Castillo, Lara, Broen, Jasper C A, Simeon, Carmen P, Beretta, Lorenzo, Vonk, Madelon C, Ortego-Centeno, Norberto, Espinosa, Gerard, Carreira, Patricia, Camps, María Teresa, Navarrete, Nuria, González-Escribano, María F, Vicente-Rabaneda, Esther, Rodríguez, Luis, Tolosa, Carlos, Román-Ivorra, José A, Gómez-Gracia, Inmaculada, García-Hernández, Francisco J, Castellví, Iván, Gallego, María, Fernández-Nebro, Antonio, García-Portales, Rosa, Egurbide, María Victoria, Fonollosa, Vicente, de la Peña, Paloma García, Pros, Ana, González-Gay, Miguel A, Hesselstrand, Roger, Riemekasten, Gabriela, Witte, Torsten, Coenen, Marieke J H, Koeleman, Bobby P, Houssiau, Frederic, Smith, Vanessa, de Keyser, Filip, Westhovens, Rene, De Langhe, Ellen, Voskuyl, Alexandre E, Schuerwegh, Annemie J, Chee, Meng May, Madhok, Rajan, Shiels, Paul, Fonseca, Carmen, Denton, Christopher, Claes, Kathleen, Padykov, Leonid, Nordin, Annika, Palm, Øyvind, Lie, Benedicte A, Airó, Paolo, Scorza, Raffaella, van Laar, Jacob M, Hunzelmann, Nicolas, Kreuter, Alexander, Herrick, Ariane, Worthington, Jane, Radstake, Timothy R D J, Martín, Javier, and Rueda, Blanca

Published
2011
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results