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450 results on '"Forghieri, Fabio"'

1. Distribution of different classes of CSF3R mutations and co-mutational pattern in 360 myeloid neoplasia

Author

Maffei, Rossana, Paolini, Ambra, Conte, Benedetta, Riva, Giovanni, Nasillo, Vincenzo, Cretì, Federica, Martinelli, Silvia, Giacobbi, Francesca, Corradini, Giorgia, Pilato, Flora, Bernabei, Daniela, Lancellotti, Cesare, Debbia, Giulia, Morselli, Monica, Potenza, Leonardo, Giusti, Davide, Colaci, Elisabetta, Bettelli, Francesca, Bresciani, Paola, Cuoghi, Angela, Gilioli, Andrea, Messerotti, Andrea, Pioli, Valeria, Maccaferri, Monica, Leonardi, Giovanna, Manfredini, Rossella, Marasca, Roberto, Eccher, Albino, Luppi, Mario, Forghieri, Fabio, Candoni, Anna, and Tagliafico, Enrico

Published
2025
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2. Management of latent tuberculosis infection (LTBI) in adult patients with newly diagnosed acute leukemia: results of a survey among Italian centers belonging to SEIFEM (Sorveglianza Epidemiologica Infezioni nelle Emopatie) group

Author

Forghieri, Fabio, Bettelli, Francesca, Sgromo, Simona, Nadali, Gianpaolo, Del Principe, Maria Ilaria, Buzzatti, Elisa, Farina, Francesca, Cesini, Laura, Giordano, Antonio, Criscuolo, Marianna, Facchinelli, Davide, Piedimonte, Monica, Sartor, Chiara, De Marchi, Roberta, Delia, Mario, Mosna, Federico, Cudillo, Laura, Tolomelli, Giulia, Basilico, Claudia Maria, Cattaneo, Chiara, Fracchiolla, Nicola Stefano, Lessi, Federica, Finizio, Olimpia, Zannetti, Beatrice Anna, Santoni, Adele, Fazi, Paola, Marchesi, Francesco, Venditti, Adriano, Candoni, Anna, Luppi, Mario, Busca, Alessandro, and Pagano, Livio

Published
2024
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3. Antiviral prophylaxis to prevent herpes simplex virus (HSV) and varicella zoster virus (VZV) reactivation in adult patients with newly diagnosed acute leukemia: results of a survey submitted to Italian centers belonging to SEIFEM (Sorveglianza Epidemiologica Infezioni nelle Emopatie) group

Author

Forghieri, Fabio, Cordella, Stefano, Marchesi, Francesco, Itri, Federico, Del Principe, Maria Ilaria, Cavalieri, Elena, Pasciolla, Crescenza, Bonanni, Matteo, Criscuolo, Marianna, Fiorentini, Alessandro, Guolo, Fabio, Buquicchio, Caterina, Prezioso, Lucia, Delia, Mario, Melillo, Lorella, Audisio, Ernesta, Zannier, Maria Elena, Cerchione, Claudio, Dargenio, Michelina, Cattaneo, Chiara, Fracchiolla, Nicola Stefano, Pezone, Sara, Perruccio, Katia, Santoni, Adele, Candoni, Anna, Vignetti, Marco, Luppi, Mario, Pagano, Livio, and Busca, Alessandro

Published
2024
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4. COVID-19 omicron variant outbreak in a hematopoietic stem cell transplant unit

Author

Gilioli, Andrea, Bresciani, Paola, Franceschini, Erica, Messerotti, Andrea, Pioli, Valeria, Colasante, Corrado, Bettelli, Francesca, Giusti, Davide, Forghieri, Fabio, Morselli, Monica, Colaci, Elisabetta, Potenza, Leonardo, Gennari, William, Pecorari, Monica, Marasca, Roberto, Candoni, Anna, Mussini, Cristina, Trenti, Tommaso, Comoli, Patrizia, Luppi, Mario, and Cuoghi, Angela

Published
2023
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5. The dynamic functions of IRF4 in B cell malignancies

Author

Maffei, Rossana, Fiorcari, Stefania, Atene, Claudio Giacinto, Martinelli, Silvia, Mesini, Nicolò, Pilato, Flora, Lagreca, Ivana, Barozzi, Patrizia, Riva, Giovanni, Nasillo, Vincenzo, Paolini, Ambra, Forghieri, Fabio, Potenza, Leonardo, Trenti, Tommaso, Tagliafico, Enrico, Luppi, Mario, and Marasca, Roberto

Published
2023
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6. Vancomycin resistant enterococcus risk factors for hospital colonization in hematological patients: a matched case-control study

Author

Meschiari, Marianna, Kaleci, Shaniko, Monte, Martina Del, Dessilani, Andrea, Santoro, Antonella, Scialpi, Francesco, Franceschini, Erica, Orlando, Gabriella, Cervo, Adriana, Monica, Morselli, Forghieri, Fabio, Venturelli, Claudia, Ricchizzi, Enrico, Chester, Johanna, Sarti, Mario, Guaraldi, Giovanni, Luppi, Mario, and Mussini, Cristina

Published
2023
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7. Predicting the next pandemic: VACCELERATE ranking of the WorldHealth Organization's Blueprint forAction toPreventEpidemics

Author

Busch, Martin, Seifert, Ulrike, Widmer, Andreas, Nagao, Miki, Rello, Jordi, Todorova, Tatina, Cviljević, Sabina, Heath, Christopher H., Jančorienė, Ligita, Fischer, Thea Koelsen, Orth, Hans Martin, Johansen, Isik Somuncu, Doymaz, Mehmet, Tragiannidis, Athanasios, Löscher, Thomas, Xu, Jin-Fu, Husa, Petr, Oteo, José Antonio, Issack, Mohammad I., Zeitlinger, Markus, Le Grand, Roger, Zdziarski, Przemysław, Demirkan, Fatih, Amador, Paloma Merino, García-Lozano, Tomás, Cao, Qing, Vázquez, Lourdes, Caeiro, Juan Pablo, Hermans, Peter, Nahrwar, Shahroch, Avsar, Korkut, Kumar, Deepak, Fernández, Norma, Mardani, Masoud, Segal, Esther, Pan, Angelo, Gkentzi, Despoina, Gioula, Georgia, Cortés, Jorge Alberto, Oliveira, Joaquim, van Damme, Pierre, Bin Mohd Zaili, Mohd Zaki, Antinori, Spinello, Zablockienė, Birutė, Papazisis, Georgios, Aneke, Chioma Inyang, Valerio, Maricela, McConkey, Samuel, Aujayeb, Avinash, Azzini, Anna Maria, Roganović, Jelena, Greve-Isdahl Mohn, Kristin, Kremsner, Peter, Gkrania-Klotsas, Effrossyni, Corzo, Dora, Khanna, Nina, Smiatacz, Tomasz, Scheithauer, Simone, Merelli, Maria, Klempa, Boris, Vrḫovac, Radovan, Ruggiero, Antonio, Chaudhary, Pankaj, Maquera-Afaray, Julio, Ekkelenkamp, Miquel, Jindra, Pavel, Pantić, Nikola, Guerra, Gemma Jiménez, Weiss, Guenter, Roohi, Behrad, Argyropoulos, Christos D., Silfverdal, Sven Aprne, van Praet, Jens, Bal, Zumrut Sahbudak, Kanj, Souha, Young, Barnaby, Pana, Zoi Dorothea, Roilides, Emmanuel, Stearns, Stephen C., Wauters, Joost, Baño, Jesús Rodríguez, Pletz, Mathias W., Travar, Maja, Kühn, Steven, Riera, Fernando, Cornely, Daniel, Laura, Vlad Jeni, Koehler, Philipp, Eley, Brian, Nair, Pravin K., Ciesek, Sandra, Olaru, Ioana Diana, Marques, Laura, Pontali, Emanuele, Naunheim, Alexandra, Lieb, Adrian, Gerhard, Markus, Farooqi, Joveria Qais, Turtle, Lance, Méndez, Gustavo Adolfo, Cox, Rebecca Jane, Goodman, Nigel, Caceca, Billie, Pemán, Javier, Dawood, Halima, Askling, Helena Hervius, Fomsgaard, Anders, Hernández, Alejandra Calderón, Staehelin, Cornelia, Liu, Chia-Ying, Icardi, Giancarlo, Castagnola, Elio, Salzer, Helmut J.F., Lundgren, Jens, Javadli, Samir, Forghieri, Fabio, Salmanton-García, Jon, Wipfler, Pauline, Leckler, Janina, Nauclér, Pontus, Mallon, Patrick W., Bruijning-Verhagen, Patricia C.J.L., Schmitt, Heinz-Joseph, Bethe, Ullrich, Olesen, Ole F., Stewart, Fiona A., Albus, Kerstin, and Cornely, Oliver A.

Published
2024
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8. Multicenter retrospective analysis of clinical outcome of adult patients with mixed-phenotype acute leukemia treated with acute myeloid leukemia–like or acute lymphoblastic leukemia–like chemotherapy and impact of allogeneic stem cell transplantation: a Campus ALL study

Author

Lazzarotto, Davide, Tanasi, Ilaria, Vitale, Antonella, Piccini, Matteo, Dargenio, Michelina, Giglio, Fabio, Forghieri, Fabio, Fracchiolla, Nicola, Cerrano, Marco, Todisco, Elisabetta, Papayannidis, Cristina, Leoncin, Matteo, Defina, Marzia, Guolo, Fabio, Pasciolla, Crescenza, Delia, Mario, Chiusolo, Patrizia, Mulè, Antonino, Candoni, Anna, Bonifacio, Massimiliano, Pizzolo, Giovanni, and Foà, Robin

Published
2023
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9. 10-day decitabine versus 3 + 7 chemotherapy followed by allografting in older patients with acute myeloid leukaemia: an open-label, randomised, controlled, phase 3 trial

Author

Finke, Jürgen, Schaap, Nicolaas Petrus Michael, Zucenka, Andrius, Metzelder, Stephan, Jost, Edgar, Perić, Zinaida, Forghieri, Fabio, Allione, Bernadino, Martelli, Maurizio, Iori, Anna Paola, Wittnebel, Sebastian, Mengarelli, Andrea, Imovilli, Annalisa, Olivieri, Attilio, De Prijck, Bernard José Marie, van der Poel, Marjolein W.M., Junghanß, Christian, Salih, Helmut Rainer, Tafuri, Agostino, Guimarães, José Eduardo, Musso, Maurizio, De Fabritiis, Paolo, Chevallier, Patrice, Selleslag, Dominik Luc, Cascavilla, Nicola, Berneman, Zwi, Jaspers, Aurélie, Zuffa, Eliana, Vanstraelen, Gaëtan, Visani, Giuseppe, Cuijpers, Maria Louisa Henriëtte, De Becker, Ann, Mianulli, Anna Maria, Hackanson, Björn, Mihaylov, Georgi Georgiev, Martinelli, Giovanni, Paolini, Stefania, Zinzani, Pier Luigi, Henkes, Martin, Al-Ali, Haifa Kathrin, La Rosée, Paul, Chierichini, Anna, Cudillo, Laura, Specchia, Giorgina, Šimec, Njetočka Gredelj, Capalbo, Silvana Franca, Spinosa, Giuseppina, Molica, Stefano, de Jonge-Peeters, Susan Dorothé, Lübbert, Michael, Wijermans, Pierre W, Kicinski, Michal, Chantepie, Sylvain, Van der Velden, Walter J F M, Noppeney, Richard, Griškevičius, Laimonas, Neubauer, Andreas, Crysandt, Martina, Vrhovac, Radovan, Luppi, Mario, Fuhrmann, Stephan, Audisio, Ernesta, Candoni, Anna, Legrand, Olivier, Foà, Robin, Gaidano, Gianluca, van Lammeren-Venema, Danielle, Posthuma, Eduardus F M, Hoogendoorn, Mels, Giraut, Anne, Stevens-Kroef, Marian, Jansen, Joop H, de Graaf, Aniek O, Efficace, Fabio, Ammatuna, Emanuele, Vilque, Jean-Pierre, Wäsch, Ralph, Becker, Heiko, Blijlevens, Nicole, Dührsen, Ulrich, Baron, Frédéric, Suciu, Stefan, Amadori, Sergio, Venditti, Adriano, and Huls, Gerwin

Published
2023
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10. Feasibility of autologous peripheral blood stem cell mobilization and harvest in adult patients with FLT3-mutated acute myeloid leukemia receiving chemotherapy combined with midostaurin: a single-center experience

Author

Cordella, Stefano, Parisotto, Angelica, Bettelli, Francesca, Morselli, Monica, Barbieri, Emiliano, Pozzi, Stefano, Aquilino, Anna, Repaci, Gianluca, Cuoghi, Angela, Bresciani, Paola, Messerotti, Andrea, Colasante, Corrado, Gilioli, Andrea, Pioli, Valeria, Giusti, Davide, Colaci, Elisabetta, Cassanelli, Luca, Ceccherelli, Giovanni, Bevini, Mirco, Malavolti, Roberta, Venturelli, Donatella, Paolini, Ambra, Martinelli, Silvia, Maffei, Rossana, Riva, Giovanni, Nasillo, Vincenzo, Trenti, Tommaso, Comoli, Patrizia, Tagliafico, Enrico, Manfredini, Rossella, Barozzi, Patrizia, Potenza, Leonardo, Marasca, Roberto, Luppi, Mario, and Forghieri, Fabio

Published
2023
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12. Chromothripsis is a frequent event and underlies typical genetic changes in early T-cell precursor lymphoblastic leukemia in adults

Author

Arniani, Silvia, Pierini, Valentina, Pellanera, Fabrizia, Matteucci, Caterina, Di Giacomo, Danika, Bardelli, Valentina, Quintini, Martina, Mavridou, Elena, Lema Fernandez, Anair Graciela, Nardelli, Carlotta, Moretti, Martina, Gorello, Paolo, Crescenzi, Barbara, Romoli, Silvia, Beacci, Donatella, Cerrano, Marco, Fracchiolla, Nicola, Sica, Simona, Forghieri, Fabio, Giglio, Fabio, Dargenio, Michela, Elia, Loredana, La Starza, Roberta, and Mecucci, Cristina

Published
2022
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13. Genomic and clinical findings in myeloid neoplasms with PDGFRB rearrangement

Author

Di Giacomo, Danika, Quintini, Martina, Pierini, Valentina, Pellanera, Fabrizia, La Starza, Roberta, Gorello, Paolo, Matteucci, Caterina, Crescenzi, Barbara, Fiumara, Paolo Fabio, Veltroni, Marinella, Borlenghi, Erika, Albano, Francesco, Forghieri, Fabio, Maccaferri, Monica, Bettelli, Francesca, Luppi, Mario, Cuneo, Antonio, Rossi, Giuseppe, and Mecucci, Cristina

Published
2022
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14. Secondary acute myeloid leukemia and early infection are independent predictors of poor survival in acute myeloid leukemia treated with hypomethylating agents and venetoclax.

Author

Cordella, Stefano, Giusti, Davide, De Bellis, Eleonora, Dargenio, Michelina, Creti', Federica, Lazzarotto, Davide, Cattaneo, Chiara, Fracchiolla, Nicola Stefano, Piccini, Matteo, Forghieri, Fabio, Pagano, Livio, and Candoni, Anna

Subjects
DISEASE risk factors, CHRONIC obstructive pulmonary disease, BIOMARKERS, ACUTE myeloid leukemia, MYELOPROLIFERATIVE neoplasms
Abstract

A study published in the journal Hematological Oncology analyzed the outcomes of 263 patients with acute myeloid leukemia (AML) who were treated with hypomethylating agents (HMAs) and venetoclax. The study aimed to identify simple baseline predictors of overall survival (OS) in this patient population. The results showed that secondary AML and early infection were independent predictors of poor survival. The study proposed a predictive OS score based on these two parameters, which could help stratify patients and personalize their care. However, further research is needed to validate these findings. [Extracted from the article]

Published
2024
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15. Early palliative care versus usual haematological care in multiple myeloma: retrospective cohort study.

Author

Giusti, Davide, Colaci, Elisabetta, Pioli, Valeria, Banchelli, Federico, Maccaferri, Monica, Leonardi, Giovanna, Marasca, Roberto, Morselli, Monica, Forghieri, Fabio, Bettelli, Francesca, Cuoghi, Angela, Bresciani, Paola, Messerotti, Andrea, Gilioli, Andrea, Candoni, Anna, Cassanelli, Luca, Sbadili, Elena, Bassoli, Ilaria, Longo, Giuseppe, and Gilioli, Fabio

Published
2024
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16. Long-term survival can be achieved in a significant fraction of older patients with core binding factor acute myeloid leukemia treated with intensive chemotherapy

Author

Mosna, F, Borlenghi, E, Litzow, M, Byrd, J, Papayannidis, C, Tecchio, C, Ferrara, F, Marcucci, G, Cairoli, R, Morgan, E, Gurrieri, C, Yeung, C, Deeg, H, Capelli, D, Candoni, A, Gotlib, J, Lunghi, M, Pullarkat, S, Lanza, F, Galimberti, S, Forghieri, F, Venditti, A, Festuccia, M, Audisio, E, Marvalle, D, Rigolin, G, Roti, G, Dibona, E, Visani, G, Albano, F, Eisfeld, A, Valent, P, Huls, G, Borthakur, G, Krampera, M, Martinelli, G, Kröger, N, Sperotto, A, Gottardi, M, Mosna, Federico, Borlenghi, Erika, Litzow, Mark, Byrd, John C, Papayannidis, Cristina, Tecchio, Cristina, Ferrara, Felicetto, Marcucci, Guido, Cairoli, Roberto, Morgan, Elizabeth A, Gurrieri, Carmela, Yeung, Cecilia C S, Deeg, H Joachim, Capelli, Debora, Candoni, Anna, Gotlib, Jason R, Lunghi, Monia, Pullarkat, Sheeja, Lanza, Francesco, Galimberti, Sara, Forghieri, Fabio, Venditti, Adriano, Festuccia, Moreno, Audisio, Ernesta, Marvalle, Denise, Rigolin, Gian Matteo, Roti, Giovanni, DiBona, Eros, Visani, Giuseppe, Albano, Francesco, Eisfeld, Ann-Kathrin, Valent, Peter, Huls, Gerwin, Borthakur, Gautam, Krampera, Mauro, Martinelli, Giovanni, Kröger, Nicolaus, Sperotto, Alessandra, Gottardi, Michele, Mosna, F, Borlenghi, E, Litzow, M, Byrd, J, Papayannidis, C, Tecchio, C, Ferrara, F, Marcucci, G, Cairoli, R, Morgan, E, Gurrieri, C, Yeung, C, Deeg, H, Capelli, D, Candoni, A, Gotlib, J, Lunghi, M, Pullarkat, S, Lanza, F, Galimberti, S, Forghieri, F, Venditti, A, Festuccia, M, Audisio, E, Marvalle, D, Rigolin, G, Roti, G, Dibona, E, Visani, G, Albano, F, Eisfeld, A, Valent, P, Huls, G, Borthakur, G, Krampera, M, Martinelli, G, Kröger, N, Sperotto, A, Gottardi, M, Mosna, Federico, Borlenghi, Erika, Litzow, Mark, Byrd, John C, Papayannidis, Cristina, Tecchio, Cristina, Ferrara, Felicetto, Marcucci, Guido, Cairoli, Roberto, Morgan, Elizabeth A, Gurrieri, Carmela, Yeung, Cecilia C S, Deeg, H Joachim, Capelli, Debora, Candoni, Anna, Gotlib, Jason R, Lunghi, Monia, Pullarkat, Sheeja, Lanza, Francesco, Galimberti, Sara, Forghieri, Fabio, Venditti, Adriano, Festuccia, Moreno, Audisio, Ernesta, Marvalle, Denise, Rigolin, Gian Matteo, Roti, Giovanni, DiBona, Eros, Visani, Giuseppe, Albano, Francesco, Eisfeld, Ann-Kathrin, Valent, Peter, Huls, Gerwin, Borthakur, Gautam, Krampera, Mauro, Martinelli, Giovanni, Kröger, Nicolaus, Sperotto, Alessandra, and Gottardi, Michele

Abstract

Acute Myeloid Leukemia is mainly a disease of the elderly: however, the knowledge on the outcomes of treatment in core binding factor AML (CBFAML) in older population, is limited. We retrospectively collected data on 229 patients with CBF- AML followed long-term in the last two decades. A 5-year overall survival (OS) of 44.2% (95%CI, 39.9-47.5) and a 5-year event - free survival (EFS) of 32.9% (95%CI, 25.5-40.1) was observed. In a subgroup of >70-year patients who completed intensive therapy (induction + >3 courses of consolidation including autologous stem cell transplant: 10 patients) the median EFS was 11.8 months (95%CI, 9.4 - 15.2) and OS was 40.0% (95%CI, 36.4 - 44.1) at 5yr. In univariate analysis, age >70 (hazard ratio (HR) 1.78, [95%CI, 1.15 - 2.54], p=.008), failure to achieve remission following induction (HR, 8.96 [95%CI, 5.5 - 13.8], p=<.0001), no consolidation therapy (HR, 0.75 [95%CI, 0.47 - 1.84], p=.04) and less than 3 cycles of consolidation (HR, 1.48 [95%CI, 0.75 - 3.2], p=.0004), predicted poorer EFS. Our study shows that intensive therapy, in selected older CBF-AML patients, leads to longer survival. Achieving a CR seems to be the most important first step and at least 3 cycles of consolidation, an important second one. The analysis suggests that these patients should not be excluded from studies with intensive therapies.

Published
2024

17. Predicting the next pandemic: VACCELERATE ranking of the World Health Organization's Blueprint for Action to Prevent Epidemics

Author

Hart- en Vaatziekten Team A, Epi Infectieziekten Team 1, Child Health, Infection & Immunity, JC onderzoeksprogramma Infectious Diseases, MMB Medische Staf, Salmanton-García, Jon, Wipfler, Pauline, Leckler, Janina, Nauclér, Pontus, Mallon, Patrick W., Bruijning-Verhagen, Patricia C.J.L., Schmitt, Heinz Joseph, Bethe, Ullrich, Olesen, Ole F., Stewart, Fiona A., Albus, Kerstin, Cornely, Oliver A., Busch, Martin, Seifert, Ulrike, Widmer, Andreas, Nagao, Miki, Rello, Jordi, Todorova, Tatina, Cviljević, Sabina, Heath, Christopher H., Jančorienė, Ligita, Fischer, Thea Koelsen, Orth, Hans Martin, Johansen, Isik Somuncu, Doymaz, Mehmet, Tragiannidis, Athanasios, Löscher, Thomas, Xu, Jin Fu, Husa, Petr, Oteo, José Antonio, Issack, Mohammad I., Zeitlinger, Markus, Le Grand, Roger, Zdziarski, Przemysław, Demirkan, Fatih, Amador, Paloma Merino, García-Lozano, Tomás, Cao, Qing, Vázquez, Lourdes, Caeiro, Juan Pablo, Hermans, Peter, Nahrwar, Shahroch, Avsar, Korkut, Kumar, Deepak, Fernández, Norma, Mardani, Masoud, Segal, Esther, Pan, Angelo, Gkentzi, Despoina, Gioula, Georgia, Cortés, Jorge Alberto, Oliveira, Joaquim, van Damme, Pierre, Bin Mohd Zaili, Mohd Zaki, Antinori, Spinello, Zablockienė, Birutė, Papazisis, Georgios, Aneke, Chioma Inyang, Valerio, Maricela, McConkey, Samuel, Aujayeb, Avinash, Azzini, Anna Maria, Roganović, Jelena, Greve-Isdahl Mohn, Kristin, Kremsner, Peter, Gkrania-Klotsas, Effrossyni, Corzo, Dora, Khanna, Nina, Smiatacz, Tomasz, Scheithauer, Simone, Merelli, Maria, Klempa, Boris, Vrḫovac, Radovan, Ruggiero, Antonio, Chaudhary, Pankaj, Maquera-Afaray, Julio, Ekkelenkamp, Miquel, Jindra, Pavel, Pantić, Nikola, Guerra, Gemma Jiménez, Weiss, Guenter, Roohi, Behrad, Argyropoulos, Christos D., Silfverdal, Sven Aprne, van Praet, Jens, Bal, Zumrut Sahbudak, Kanj, Souha, Young, Barnaby, Pana, Zoi Dorothea, Roilides, Emmanuel, Stearns, Stephen C., Wauters, Joost, Baño, Jesús Rodríguez, Pletz, Mathias W., Travar, Maja, Kühn, Steven, Riera, Fernando, Cornely, Daniel, Laura, Vlad Jeni, Koehler, Philipp, Eley, Brian, Nair, Pravin K., Ciesek, Sandra, Olaru, Ioana Diana, Marques, Laura, Pontali, Emanuele, Naunheim, Alexandra, Lieb, Adrian, Gerhard, Markus, Farooqi, Joveria Qais, Turtle, Lance, Méndez, Gustavo Adolfo, Cox, Rebecca Jane, Goodman, Nigel, Caceca, Billie, Pemán, Javier, Dawood, Halima, Askling, Helena Hervius, Fomsgaard, Anders, Hernández, Alejandra Calderón, Staehelin, Cornelia, Liu, Chia Ying, Icardi, Giancarlo, Castagnola, Elio, Salzer, Helmut J.F., Lundgren, Jens, Javadli, Samir, Forghieri, Fabio, Hart- en Vaatziekten Team A, Epi Infectieziekten Team 1, Child Health, Infection & Immunity, JC onderzoeksprogramma Infectious Diseases, MMB Medische Staf, Salmanton-García, Jon, Wipfler, Pauline, Leckler, Janina, Nauclér, Pontus, Mallon, Patrick W., Bruijning-Verhagen, Patricia C.J.L., Schmitt, Heinz Joseph, Bethe, Ullrich, Olesen, Ole F., Stewart, Fiona A., Albus, Kerstin, Cornely, Oliver A., Busch, Martin, Seifert, Ulrike, Widmer, Andreas, Nagao, Miki, Rello, Jordi, Todorova, Tatina, Cviljević, Sabina, Heath, Christopher H., Jančorienė, Ligita, Fischer, Thea Koelsen, Orth, Hans Martin, Johansen, Isik Somuncu, Doymaz, Mehmet, Tragiannidis, Athanasios, Löscher, Thomas, Xu, Jin Fu, Husa, Petr, Oteo, José Antonio, Issack, Mohammad I., Zeitlinger, Markus, Le Grand, Roger, Zdziarski, Przemysław, Demirkan, Fatih, Amador, Paloma Merino, García-Lozano, Tomás, Cao, Qing, Vázquez, Lourdes, Caeiro, Juan Pablo, Hermans, Peter, Nahrwar, Shahroch, Avsar, Korkut, Kumar, Deepak, Fernández, Norma, Mardani, Masoud, Segal, Esther, Pan, Angelo, Gkentzi, Despoina, Gioula, Georgia, Cortés, Jorge Alberto, Oliveira, Joaquim, van Damme, Pierre, Bin Mohd Zaili, Mohd Zaki, Antinori, Spinello, Zablockienė, Birutė, Papazisis, Georgios, Aneke, Chioma Inyang, Valerio, Maricela, McConkey, Samuel, Aujayeb, Avinash, Azzini, Anna Maria, Roganović, Jelena, Greve-Isdahl Mohn, Kristin, Kremsner, Peter, Gkrania-Klotsas, Effrossyni, Corzo, Dora, Khanna, Nina, Smiatacz, Tomasz, Scheithauer, Simone, Merelli, Maria, Klempa, Boris, Vrḫovac, Radovan, Ruggiero, Antonio, Chaudhary, Pankaj, Maquera-Afaray, Julio, Ekkelenkamp, Miquel, Jindra, Pavel, Pantić, Nikola, Guerra, Gemma Jiménez, Weiss, Guenter, Roohi, Behrad, Argyropoulos, Christos D., Silfverdal, Sven Aprne, van Praet, Jens, Bal, Zumrut Sahbudak, Kanj, Souha, Young, Barnaby, Pana, Zoi Dorothea, Roilides, Emmanuel, Stearns, Stephen C., Wauters, Joost, Baño, Jesús Rodríguez, Pletz, Mathias W., Travar, Maja, Kühn, Steven, Riera, Fernando, Cornely, Daniel, Laura, Vlad Jeni, Koehler, Philipp, Eley, Brian, Nair, Pravin K., Ciesek, Sandra, Olaru, Ioana Diana, Marques, Laura, Pontali, Emanuele, Naunheim, Alexandra, Lieb, Adrian, Gerhard, Markus, Farooqi, Joveria Qais, Turtle, Lance, Méndez, Gustavo Adolfo, Cox, Rebecca Jane, Goodman, Nigel, Caceca, Billie, Pemán, Javier, Dawood, Halima, Askling, Helena Hervius, Fomsgaard, Anders, Hernández, Alejandra Calderón, Staehelin, Cornelia, Liu, Chia Ying, Icardi, Giancarlo, Castagnola, Elio, Salzer, Helmut J.F., Lundgren, Jens, Javadli, Samir, and Forghieri, Fabio

Published
2024

18. Predicting the next pandemic: VACCELERATE ranking of the World Health Organization's Blueprint for Action to Prevent Epidemics

Author

Salmanton-García, Jon, primary, Wipfler, Pauline, additional, Leckler, Janina, additional, Nauclér, Pontus, additional, Mallon, Patrick W., additional, Bruijning-Verhagen, Patricia C.J.L., additional, Schmitt, Heinz-Joseph, additional, Bethe, Ullrich, additional, Olesen, Ole F., additional, Stewart, Fiona A., additional, Albus, Kerstin, additional, Cornely, Oliver A., additional, Busch, Martin, additional, Seifert, Ulrike, additional, Widmer, Andreas, additional, Nagao, Miki, additional, Rello, Jordi, additional, Todorova, Tatina, additional, Cviljević, Sabina, additional, Heath, Christopher H., additional, Jančorienė, Ligita, additional, Fischer, Thea Koelsen, additional, Orth, Hans Martin, additional, Johansen, Isik Somuncu, additional, Doymaz, Mehmet, additional, Tragiannidis, Athanasios, additional, Löscher, Thomas, additional, Xu, Jin-Fu, additional, Husa, Petr, additional, Oteo, José Antonio, additional, Issack, Mohammad I., additional, Zeitlinger, Markus, additional, Le Grand, Roger, additional, Zdziarski, Przemysław, additional, Demirkan, Fatih, additional, Amador, Paloma Merino, additional, García-Lozano, Tomás, additional, Cao, Qing, additional, Vázquez, Lourdes, additional, Caeiro, Juan Pablo, additional, Hermans, Peter, additional, Nahrwar, Shahroch, additional, Avsar, Korkut, additional, Kumar, Deepak, additional, Fernández, Norma, additional, Mardani, Masoud, additional, Segal, Esther, additional, Pan, Angelo, additional, Gkentzi, Despoina, additional, Gioula, Georgia, additional, Cortés, Jorge Alberto, additional, Oliveira, Joaquim, additional, van Damme, Pierre, additional, Bin Mohd Zaili, Mohd Zaki, additional, Antinori, Spinello, additional, Zablockienė, Birutė, additional, Papazisis, Georgios, additional, Aneke, Chioma Inyang, additional, Valerio, Maricela, additional, McConkey, Samuel, additional, Aujayeb, Avinash, additional, Azzini, Anna Maria, additional, Roganović, Jelena, additional, Greve-Isdahl Mohn, Kristin, additional, Kremsner, Peter, additional, Gkrania-Klotsas, Effrossyni, additional, Corzo, Dora, additional, Khanna, Nina, additional, Smiatacz, Tomasz, additional, Scheithauer, Simone, additional, Merelli, Maria, additional, Klempa, Boris, additional, Vrḫovac, Radovan, additional, Ruggiero, Antonio, additional, Chaudhary, Pankaj, additional, Maquera-Afaray, Julio, additional, Ekkelenkamp, Miquel, additional, Jindra, Pavel, additional, Pantić, Nikola, additional, Guerra, Gemma Jiménez, additional, Weiss, Guenter, additional, Roohi, Behrad, additional, Argyropoulos, Christos D., additional, Silfverdal, Sven Aprne, additional, van Praet, Jens, additional, Bal, Zumrut Sahbudak, additional, Kanj, Souha, additional, Young, Barnaby, additional, Pana, Zoi Dorothea, additional, Roilides, Emmanuel, additional, Stearns, Stephen C., additional, Wauters, Joost, additional, Baño, Jesús Rodríguez, additional, Pletz, Mathias W., additional, Travar, Maja, additional, Kühn, Steven, additional, Riera, Fernando, additional, Cornely, Daniel, additional, Laura, Vlad Jeni, additional, Koehler, Philipp, additional, Eley, Brian, additional, Nair, Pravin K., additional, Ciesek, Sandra, additional, Olaru, Ioana Diana, additional, Marques, Laura, additional, Pontali, Emanuele, additional, Naunheim, Alexandra, additional, Lieb, Adrian, additional, Gerhard, Markus, additional, Farooqi, Joveria Qais, additional, Turtle, Lance, additional, Méndez, Gustavo Adolfo, additional, Cox, Rebecca Jane, additional, Goodman, Nigel, additional, Caceca, Billie, additional, Pemán, Javier, additional, Dawood, Halima, additional, Askling, Helena Hervius, additional, Fomsgaard, Anders, additional, Hernández, Alejandra Calderón, additional, Staehelin, Cornelia, additional, Liu, Chia-Ying, additional, Icardi, Giancarlo, additional, Castagnola, Elio, additional, Salzer, Helmut J.F., additional, Lundgren, Jens, additional, Javadli, Samir, additional, and Forghieri, Fabio, additional

Published
2024
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19. Identification and validation of diagnostic cut-offs of the ELISpot assay for the diagnosis of invasive aspergillosis in high-risk patients.

Author

Bettelli, Francesca, Vallerini, Daniela, Lagreca, Ivana, Barozzi, Patrizia, Riva, Giovanni, Nasillo, Vincenzo, Paolini, Ambra, D'Amico, Roberto, Forghieri, Fabio, Morselli, Monica, Pioli, Valeria, Gilioli, Andrea, Giusti, Davide, Messerotti, Andrea, Bresciani, Paola, Cuoghi, Angela, Colaci, Elisabetta, Marasca, Roberto, Pagano, Livio, and Candoni, Anna

Subjects
ASPERGILLOSIS, HEMATOLOGIC malignancies, T cells, SENSITIVITY & specificity (Statistics), INTERLEUKIN-10
Abstract

Objective: We investigated the performance of enzyme linked immunospot (ELISpot) assay for the diagnosis of invasive aspergillosis (IA) in high-risk patients with hematologic malignancies. Methods: We prospectively enrolled two cohorts of patients undergoing intensive myelosuppressive or immunosuppressive treatments at high risk for IA. ELISpot was performed to detect Aspergillus-specific T cells producing Interleukin-10. Results: In the discovery cohort, a derived cut-off of 40 spot forming cells (SFCs)/106 PBMCs has shown to correctly classify IA cases with a sensitivity and specificity of 89.5% and 88.6%, respectively. This cut-off is lowered to 25 SFC when considering the subset of possible IA patients, with sensitivity and specificity of 76% and 93%, respectively. The application of the 40 SFCs cut-off to the validation cohort resulted in a positivity rate of 83.3% in proven/probable cases and a negativity rate of 92.5% in possible/non-IA cases. Adopting the 25 SCFs cut-off, the assay resulted positive in 83.3% of proven/probable cases while it resulted negative in 66.7% of possible/non-IA cases. Conclusions: ELISpot shows promises in the diagnosis of IA and the possibility to use two distinct cut-offs with similar diagnostic performances according to patients' different pre-test probability of infection can widen its use in patients at risk. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Characteristics and clinical behavior of acute myeloid leukemia harboring rare non-A/B/D nucleophosmin ( NPM1 ) gene mutation subtypes: a single-center experience and review of the literature

Author

Mutti, Martina, primary, Cordella, Stefano, additional, Parisotto, Angelica, additional, Bettelli, Francesca, additional, Morselli, Monica, additional, Cuoghi, Angela, additional, Bresciani, Paola, additional, Messerotti, Andrea, additional, Gilioli, Andrea, additional, Pioli, Valeria, additional, Giusti, Davide, additional, Colaci, Elisabetta, additional, Cassanelli, Luca, additional, Paolini, Ambra, additional, Martinelli, Silvia, additional, Maffei, Rossana, additional, Riva, Giovanni, additional, Nasillo, Vincenzo, additional, Sarti, Mario, additional, Trenti, Tommaso, additional, Comoli, Patrizia, additional, Tagliafico, Enrico, additional, Manfredini, Rossella, additional, Eccher, Albino, additional, Lagreca, Ivana, additional, Barozzi, Patrizia, additional, Potenza, Leonardo, additional, Marasca, Roberto, additional, Candoni, Anna, additional, Luppi, Mario, additional, and Forghieri, Fabio, additional

Published
2023
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21. Early palliative care versus usual haematological care in multiple myeloma: retrospective cohort study

Author

Giusti, Davide, primary, Colaci, Elisabetta, additional, Pioli, Valeria, additional, Banchelli, Federico, additional, Maccaferri, Monica, additional, Leonardi, Giovanna, additional, Marasca, Roberto, additional, Morselli, Monica, additional, Forghieri, Fabio, additional, Bettelli, Francesca, additional, Cuoghi, Angela, additional, Bresciani, Paola, additional, Messerotti, Andrea, additional, Gilioli, Andrea, additional, Candoni, Anna, additional, Cassanelli, Luca, additional, Sbadili, Elena, additional, Bassoli, Ilaria, additional, Longo, Giuseppe, additional, Gilioli, Fabio, additional, Borelli, Eleonora, additional, Bigi, Sarah, additional, D'Amico, Roberto, additional, Porro, Carlo Adolfo, additional, Odejide, Oreofe, additional, Zimmermann, Camilla, additional, Efficace, Fabio, additional, Bruera, Eduardo, additional, Luppi, Mario, additional, Bandieri, Elena, additional, and Potenza, Leonardo, additional

Published
2023
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22. Blinatumomab and Inotuzumab Ozogamicin Sequential Use for the Treatment of Relapsed/Refractory Acute Lymphoblastic Leukemia: A Real-Life Campus All Study

Author

Fracchiolla, Nicola Stefano, primary, Sciumè, Mariarita, additional, Papayannidis, Cristina, additional, Vitale, Antonella, additional, Chiaretti, Sabina, additional, Annunziata, Mario, additional, Giglio, Fabio, additional, Salutari, Prassede, additional, Forghieri, Fabio, additional, Lazzarotto, Davide, additional, Lunghi, Monia, additional, Imovilli, Annalisa, additional, Scappini, Barbara, additional, Bonifacio, Massimiliano, additional, Dargenio, Michelina, additional, Gurrieri, Carmela, additional, Todisco, Elisabetta, additional, Defina, Marzia, additional, Del Principe, Maria Ilaria, additional, Zappasodi, Patrizia, additional, Cerrano, Marco, additional, Santoro, Lidia, additional, Tagliaferri, Elena, additional, Barozzi, Enrico, additional, De Roberto, Pasquale, additional, Canzi, Marta, additional, Buzzatti, Elisa, additional, Sartor, Chiara, additional, Passamonti, Francesco, additional, Foà, Robin, additional, and Curti, Antonio, additional

Published
2023
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23. Characterization of FLT3-ITDmut acute myeloid leukemia: molecular profiling of leukemic precursor cells

Author

Travaglini, Serena, Angelini, Daniela Francesca, Alfonso, Valentina, Guerrera, Gisella, Lavorgna, Serena, Divona, Mariadomenica, Nardozza, Anna Maria, Consalvo, Maria Irno, Fabiani, Emiliano, De Bardi, Marco, Neri, Benedetta, Forghieri, Fabio, Marchesi, Francesco, Paterno, Giovangiacinto, Cerretti, Raffaella, Barragan, Eva, Fiori, Valentina, Dominici, Sabrina, Del Principe, Maria Ilaria, Venditti, Adriano, Battistini, Luca, Arcese, William, Lo-Coco, Francesco, Voso, Maria Teresa, and Ottone, Tiziana

Published
2020
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24. Investigating the association between physicians self-efficacy regarding communication skills and risk of “burnout”

Author

Messerotti, Andrea, Banchelli, Federico, Ferrari, Silvia, Barbieri, Emiliano, Bettelli, Francesca, Bandieri, Elena, Giusti, Davide, Catellani, Hillary, Borelli, Eleonora, Colaci, Elisabetta, Pioli, Valeria, Morselli, Monica, Forghieri, Fabio, Galeazzi, Gian Maria, Marasca, Roberto, Bigi, Sarah, D’Amico, Roberto, Martin, Peter, Efficace, Fabio, Luppi, Mario, and Potenza, Leonardo

Published
2020
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25. Early palliative/supportive care in acute myeloid leukaemia allows low aggression end-of-life interventions: observational outpatient study.

Author

Potenza, Leonardo, Scaravaglio, Miki, Fortuna, Daniela, Giusti, Davide, Colaci, Elisabetta, Pioli, Valeria, Morselli, Monica, Forghieri, Fabio, Bettelli, Francesca, Messerotti, Andrea, Catellani, Hillary, Gilioli, Andrea, Marasca, Roberto, Borelli, Eleonora, Bigi, Sarah, Longo, Giuseppe, Banchelli, Federico, D'Amico, Roberto, Back, Anthony L., and Efficace, Fabio

Published
2024
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27. Preclinical Validation of an Advanced Therapy Medicinal Product Based on Cytotoxic T Lymphocytes Specific for Mutated Nucleophosmin (NPM1mut) for the Treatment of NPM1mut-Acute Myeloid Leukemia

Author

De Cicco, Marica, primary, Lagreca, Ivana, additional, Basso, Sabrina, additional, Barozzi, Patrizia, additional, Muscianisi, Stella, additional, Bianco, Alba, additional, Riva, Giovanni, additional, Di Vincenzo, Sara, additional, Pulvirenti, Chiara, additional, Sapuppo, Davide, additional, Siciliano, Mariangela, additional, Rosti, Vittorio, additional, Candoni, Anna, additional, Zecca, Marco, additional, Forghieri, Fabio, additional, Luppi, Mario, additional, and Comoli, Patrizia, additional

Published
2023
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28. Extracting Information from Google Fusion Tables

Author

Brambilla, Marco, Ceri, Stefano, Cinefra, Nicola, Das Sarma, Anish, Forghieri, Fabio, Quarteroni, Silvia, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Ceri, Stefano, editor, and Brambilla, Marco, editor

Published
2012
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30. Prognostic Relevance of Multi-Antigenic Myeloma-Specific T-Cell Assay in Patients with Monoclonal Gammopathies

Author

Lagreca, Ivana, primary, Nasillo, Vincenzo, additional, Barozzi, Patrizia, additional, Castelli, Ilaria, additional, Basso, Sabrina, additional, Castellano, Sara, additional, Paolini, Ambra, additional, Maccaferri, Monica, additional, Colaci, Elisabetta, additional, Vallerini, Daniela, additional, Natali, Patrizia, additional, Debbia, Daria, additional, Pirotti, Tommaso, additional, Ottomano, Anna Maria, additional, Maffei, Rossana, additional, Bettelli, Francesca, additional, Giusti, Davide, additional, Messerotti, Andrea, additional, Gilioli, Andrea, additional, Pioli, Valeria, additional, Leonardi, Giovanna, additional, Forghieri, Fabio, additional, Bresciani, Paola, additional, Cuoghi, Angela, additional, Morselli, Monica, additional, Manfredini, Rossella, additional, Longo, Giuseppe, additional, Candoni, Anna, additional, Marasca, Roberto, additional, Potenza, Leonardo, additional, Tagliafico, Enrico, additional, Trenti, Tommaso, additional, Comoli, Patrizia, additional, Luppi, Mario, additional, and Riva, Giovanni, additional

Published
2023
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31. The dynamic functions of IRF4 in B cell malignancies

Author

Maffei, Rossana, primary, Fiorcari, Stefania, additional, Atene, Claudio Giacinto, additional, Martinelli, Silvia, additional, Mesini, Nicolò, additional, Pilato, Flora, additional, Lagreca, Ivana, additional, Barozzi, Patrizia, additional, Riva, Giovanni, additional, Nasillo, Vincenzo, additional, Paolini, Ambra, additional, Forghieri, Fabio, additional, Potenza, Leonardo, additional, Trenti, Tommaso, additional, Tagliafico, Enrico, additional, Luppi, Mario, additional, and Marasca, Roberto, additional

Published
2022
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32. Blinatumomab differentially modulates peripheral blood and bone marrow immune cell repertoire: A Campus ALL study.

Author

Ocadlikova, Darina, Lussana, Federico, Fracchiolla, Nicola, Bonifacio, Massimiliano, Santoro, Lidia, Delia, Mario, Chiaretti, Sabina, Pasciolla, Crescenza, Cignetti, Alessandro, Forghieri, Fabio, Grimaldi, Francesco, Corradi, Giulia, Zannoni, Letizia, De Propris, Stefania, Borleri, Gian Maria, Tanasi, Ilaria, Vadakekolathu, Jayakumar, Rutella, Sergio, Guarini, Anna Rita, and Foà, Robin

Subjects
BONE marrow cells, REGULATORY T cells, LYMPHOBLASTIC leukemia, KILLER cells, IMMUNE checkpoint proteins
Abstract

Summary: Blinatumomab is the first bi‐specific T‐cell engager approved for relapsed or refractory B‐cell precursor acute lymphoblastic leukaemia (B‐ALL). Despite remarkable clinical results, the effects of blinatumomab on the host immune cell repertoire are not fully elucidated. In the present study, we characterized the peripheral blood (PB) and, for the first time, the bone marrow (BM) immune cell repertoire upon blinatumomab treatment. Twenty‐nine patients with B‐ALL received blinatumomab according to clinical practice. Deep multiparametric flow cytometry was used to characterize lymphoid subsets during the first treatment cycle. Blinatumomab induced a transient redistribution of PB effector T‐cell subsets and Treg cells with a persistent increase in cytotoxic NK cells, which was associated with a transient upregulation of immune checkpoint receptors on PB CD4 and CD8 T‐cell subpopulations and of CD39 expression on suppressive Treg cells. Of note, BM immune T‐cell subsets showed a broader post‐treatment subversion, including the modulation of markers associated with a T‐cell‐exhausted phenotype. In conclusion, our study indicates that blinatumomab differentially modulates the PB and BM immune cell repertoire, which may have relevant clinical implications in the therapeutic setting. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Incidence, treatment and outcome of central nervous system relapse in adult acute lymphoblastic leukaemia patients treated front‐line with paediatric‐inspired regimens: A retrospective multicentre Campus ALL study

Author

Dargenio, Michelina, primary, Bonifacio, Massimiliano, additional, Chiaretti, Sabina, additional, Vitale, Antonella, additional, Fracchiolla, Nicola Stefano, additional, Papayannidis, Cristina, additional, Giglio, Fabio, additional, Salutari, Prassede, additional, Audisio, Ernesta, additional, Scappini, Barbara, additional, Zappasodi, Patrizia, additional, Defina, Marzia, additional, Forghieri, Fabio, additional, Scattolin, Anna Maria, additional, Todisco, Elisabetta, additional, Lunghi, Monia, additional, Guolo, Fabio, additional, Del Principe, Maria Ilaria, additional, Annunziata, Mario, additional, Lazzarotto, Davide, additional, Cedrone, Michele, additional, Pasciolla, Crescenza, additional, Imovilli, Annalisa, additional, Tanasi, Ilaria, additional, Trappolini, Silvia, additional, Cerrano, Marco, additional, La Starza, Roberta, additional, Krampera, Mauro, additional, Di Renzo, Nicola, additional, Candoni, Anna, additional, Pizzolo, Giovanni, additional, Ferrara, Felicetto, additional, and Foà, Robin, additional

Published
2022
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34. Levocarnitine supplementation for asparaginase-induced hepatotoxicity in adult acute lymphoblastic leukemia patients: A multicenter observational study of the campus all group

Author

Defina, Marzia, primary, Lazzarotto, Davide, additional, Guolo, Fabio, additional, Minetto, Paola, additional, Fracchiolla, Nicola Stefano, additional, Giglio, Fabio, additional, Forghieri, Fabio, additional, Vitale, Antonella, additional, Chiaretti, Sabina, additional, Papayannidis, Cristina, additional, Piccini, Matteo, additional, Mulè, Antonino, additional, Bocchia, Monica, additional, Leoncin, Matteo, additional, Gurrieri, Carmela, additional, Aprile, Lara, additional, Lunghi, Monia, additional, Bonifacio, Massimiliano, additional, Pasciolla, Crescenza, additional, Cerrano, Marco, additional, Fumagalli, Monica, additional, Foà, Robin, additional, and Candoni, Anna, additional

Published
2022
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35. Feasibility of autologous peripheral blood stem cell mobilization and harvest in adult patients with FLT3-mutated acute myeloid leukemia receiving chemotherapy combined with midostaurin: a single-center experience

Author

Cordella, Stefano, primary, Parisotto, Angelica, additional, Bettelli, Francesca, additional, Morselli, Monica, additional, Barbieri, Emiliano, additional, Pozzi, Stefano, additional, Aquilino, Anna, additional, Repaci, Gianluca, additional, Cuoghi, Angela, additional, Bresciani, Paola, additional, Messerotti, Andrea, additional, Colasante, Corrado, additional, Gilioli, Andrea, additional, Pioli, Valeria, additional, Giusti, Davide, additional, Colaci, Elisabetta, additional, Cassanelli, Luca, additional, Ceccherelli, Giovanni, additional, Bevini, Mirco, additional, Malavolti, Roberta, additional, Venturelli, Donatella, additional, Paolini, Ambra, additional, Martinelli, Silvia, additional, Maffei, Rossana, additional, Riva, Giovanni, additional, Nasillo, Vincenzo, additional, Trenti, Tommaso, additional, Comoli, Patrizia, additional, Tagliafico, Enrico, additional, Manfredini, Rossella, additional, Barozzi, Patrizia, additional, Potenza, Leonardo, additional, Marasca, Roberto, additional, Luppi, Mario, additional, and Forghieri, Fabio, additional

Published
2022
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37. Epidemiology and clinical outcome of lower respiratory tract infections by respiratory syncytial virus or parainfluenza virus type 3 in adults receiving treatment for either acute leukemia or severe aplastic anemia: a retrospective single center study

Author

Bigliardi, Sara, Morselli, Monica, Potenza, Leonardo, Riva, Giovanni, Coluccio, Valeria, Maccaferri, Monica, Paolini, Ambra, Colaci, Elisabetta, Fantuzzi, Valeria, Soci, Francesco, Nasillo, Vincenzo, Messerotti, Andrea, Arletti, Laura, Pioli, Valeria, Lugli, Elisabetta, Gilioli, Andrea, Quadrelli, Chiara, Vallerini, Daniela, Barozzi, Patrizia, Lagreca, Ivana, Marasca, Roberto, Narni, Franco, Franceschini, Erica, Codeluppi, Mauro, Mussini, Cristina, Luppi, Mario, and Forghieri, Fabio

Published
2015
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38. Edmonton symptom assessment system Global Distress Score and overall survival in acute leukaemia

Author

Morselli, Monica, primary, Banchelli, Federico, additional, Borelli, Eleonora, additional, Cordella, Stefano, additional, Forghieri, Fabio, additional, Bettelli, Francesca, additional, Bigi, Sarah, additional, Longo, Giuseppe, additional, D'Amico, Roberto, additional, Porro, Carlo Adolfo, additional, Efficace, Fabio, additional, Bruera, Eduardo, additional, Luppi, Mario, additional, Bandieri, Elena, additional, and Potenza, Leonardo, additional

Published
2022
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39. Prevalence and Prognostic Role of IDH Mutations in Acute Myeloid Leukemia: Results of the GIMEMA AML1516 Protocol

Author

Messina, Monica, primary, Piciocchi, Alfonso, additional, Ottone, Tiziana, additional, Paolini, Stefania, additional, Papayannidis, Cristina, additional, Lessi, Federica, additional, Fracchiolla, Nicola Stefano, additional, Forghieri, Fabio, additional, Candoni, Anna, additional, Mengarelli, Andrea, additional, Martelli, Maria Paola, additional, Venditti, Adriano, additional, Carella, Angelo Michele, additional, Albano, Francesco, additional, Mancini, Valentina, additional, Massimo, Bernardi, additional, Arena, Valentina, additional, Sargentini, Valeria, additional, Sciumè, Mariarita, additional, Pastore, Domenico, additional, Todisco, Elisabetta, additional, Roti, Giovanni, additional, Siragusa, Sergio, additional, Ladetto, Marco, additional, Pravato, Stefano, additional, De Bellis, Eleonora, additional, Simonetti, Giorgia, additional, Marconi, Giovanni, additional, Cerchione, Claudio, additional, Fazi, Paola, additional, Vignetti, Marco, additional, Amadori, Sergio, additional, Martinelli, Giovanni, additional, and Voso, Maria Teresa, additional

Published
2022
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40. 10-day decitabine versus 3 + 7 chemotherapy followed by allografting in older patients with acute myeloid leukaemia: an open-label, randomised, controlled, phase 3 trial

Author

Lübbert, Michael, Wijermans, Pierre W, Kicinski, Michal, Chantepie, Sylvain, Van der Velden, Walter J F M, Noppeney, Richard, Griškevičius, Laimonas, Neubauer, Andreas, Crysandt, Martina, Vrhovac, Radovan, Luppi, Mario, Fuhrmann, Stephan, Audisio, Ernesta, Candoni, Anna, Legrand, Olivier, Foà, Robin, Gaidano, Gianluca, van Lammeren-Venema, Danielle, Posthuma, Eduardus F M, Hoogendoorn, Mels, Giraut, Anne, Stevens-Kroef, Marian, Jansen, Joop H, de Graaf, Aniek O, Efficace, Fabio, Ammatuna, Emanuele, Vilque, Jean-Pierre, Wäsch, Ralph, Becker, Heiko, Blijlevens, Nicole, Dührsen, Ulrich, Baron, Frédéric, Suciu, Stefan, Amadori, Sergio, Venditti, Adriano, Huls, Gerwin, Finke, Jürgen, Schaap, Nicolaas Petrus Michael, Zucenka, Andrius, Metzelder, Stephan, Jost, Edgar, Perić, Zinaida, Forghieri, Fabio, Allione, Bernadino, Martelli, Maurizio, Iori, Anna Paola, Wittnebel, Sebastian, Mengarelli, Andrea, Imovilli, Annalisa, Olivieri, Attilio, De Prijck, Bernard José Marie, van der Poel, Marjolein W.M., Junghanß, Christian, Salih, Helmut Rainer, Tafuri, Agostino, Guimarães, José Eduardo, Musso, Maurizio, De Fabritiis, Paolo, Chevallier, Patrice, Selleslag, Dominik Luc, Cascavilla, Nicola, Berneman, Zwi, Jaspers, Aurélie, Zuffa, Eliana, Vanstraelen, Gaëtan, Visani, Giuseppe, Cuijpers, Maria Louisa Henriëtte, De Becker, Ann, Mianulli, Anna Maria, Hackanson, Björn, Mihaylov, Georgi Georgiev, Martinelli, Giovanni, Paolini, Stefania, Zinzani, Pier Luigi, Henkes, Martin, Al-Ali, Haifa Kathrin, La Rosée, Paul, Chierichini, Anna, Cudillo, Laura, Specchia, Giorgina, Šimec, Njetočka Gredelj, Capalbo, Silvana Franca, Spinosa, Giuseppina, Molica, Stefano, and de Jonge-Peeters, Susan Dorothé

Abstract

Many older patients with acute myeloid leukaemia die or cannot undergo allogeneic haematopoietic stem-cell transplantation (HSCT) due to toxicity caused by intensive chemotherapy. We hypothesised that replacing intensive chemotherapy with decitabine monotherapy could improve outcomes.

Published
2023
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41. The Role of T Cell Immunity in Monoclonal Gammopathy and Multiple Myeloma: From Immunopathogenesis to Novel Therapeutic Approaches

Author

Lagreca, Ivana, primary, Riva, Giovanni, additional, Nasillo, Vincenzo, additional, Barozzi, Patrizia, additional, Castelli, Ilaria, additional, Basso, Sabrina, additional, Bettelli, Francesca, additional, Giusti, Davide, additional, Cuoghi, Angela, additional, Bresciani, Paola, additional, Messerotti, Andrea, additional, Gilioli, Andrea, additional, Pioli, Valeria, additional, Colasante, Corrado, additional, Vallerini, Daniela, additional, Paolini, Ambra, additional, Maccaferri, Monica, additional, Donatelli, Francesca, additional, Forghieri, Fabio, additional, Morselli, Monica, additional, Colaci, Elisabetta, additional, Leonardi, Giovanna, additional, Marasca, Roberto, additional, Potenza, Leonardo, additional, Manfredini, Rossella, additional, Tagliafico, Enrico, additional, Trenti, Tommaso, additional, Comoli, Patrizia, additional, and Luppi, Mario, additional

Published
2022
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42. COVID-19 infection in acute lymphoblastic leukemia over 15 months of the pandemic. A Campus ALL report

Author

Chiaretti, Sabina, primary, Bonifacio, Massimiliano, additional, Agrippino, Roberta, additional, Giglio, Fabio, additional, Annunziata, Mario, additional, Curti, Antonio, additional, Principe, Maria Ilaria Del, additional, Salutari, Prassede, additional, Sciumè, Mariarita, additional, Delia, Mario, additional, Armenio, Marco, additional, Mancini, Valentina, additional, Mulè, Antonino, additional, Grimaldi, Francesco, additional, Rege-Cambrin, Giovanna, additional, Santoro, Lidia, additional, Lussana, Federico, additional, Chiusolo, Patrizia, additional, Pasciolla, Crescenza, additional, Scattolin, Anna Maria, additional, Cerrano, Marco, additional, Ciccone, Maria, additional, Defina, Marzia, additional, Forghieri, Fabio, additional, Mazzone, Carla, additional, Piccini, Matteo, additional, Ferrara, Felicetto, additional, Pizzolo, Giovanni, additional, and Foà, Robin, additional

Published
2022
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43. In BCR-ABL1 Positive B-Cell Acute Lymphoblastic Leukemia, Steroid Therapy Induces Hypofibrinogenemia

Author

Buzzatti, Elisa, primary, Forghieri, Fabio, additional, Paterno, Giovangiacinto, additional, Marchesi, Francesco, additional, Sarlo, Chiara, additional, Giglio, Fabio, additional, Fracchiolla, Nicola, additional, Sciumè, Mariarita, additional, Palmieri, Raffaele, additional, Esposito, Fabiana, additional, Guarnera, Luca, additional, Mercante, Lisa, additional, Pascale, Maria Rosaria, additional, Mallegni, Flavia, additional, Savi, Arianna, additional, Forte, Vittorio, additional, Maurillo, Luca, additional, Buccisano, Francesco, additional, Venditti, Adriano, additional, and Del Principe, Maria Ilaria, additional

Published
2022
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44. BTK Inhibitors Impair Platelet-Mediated Antifungal Activity

Author

Nasillo, Vincenzo, primary, Lagreca, Ivana, additional, Vallerini, Daniela, additional, Barozzi, Patrizia, additional, Riva, Giovanni, additional, Maccaferri, Monica, additional, Paolini, Ambra, additional, Forghieri, Fabio, additional, Fiorcari, Stefania, additional, Maffei, Rossana, additional, Martinelli, Silvia, additional, Atene, Claudio Giacinto, additional, Castelli, Ilaria, additional, Marasca, Roberto, additional, Potenza, Leonardo, additional, Comoli, Patrizia, additional, Manfredini, Rossella, additional, Tagliafico, Enrico, additional, Trenti, Tommaso, additional, and Luppi, Mario, additional

Published
2022
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45. Daratumumab with or without chemotherapy in relapsed and refractory acute lymphoblastic leukemia. A retrospective observational Campus Acute Lymphoblastic Leukemia study

Author

Cerrano, Marco, Bonifacio, Massimiliano, Olivi, Matteo, Curti, Antonio, Malagola, Michele, Dargenio, Michelina, Scattolin, Anna Maria, Papayannidis, Cristina, Forghieri, Fabio, Gurrieri, Carmela, Tanasi, Ilaria, Zappasodi, Patrizia, La Starza, Roberta, Fracchiolla, Nicola Stefano, Chiusolo, Patrizia, Giaccone, Luisa, Del Principe, Maria Ilaria, Giglio, Fabio, Defina, Marzia, Favre, Claudio, Rizzari, Carmelo, Castella, Barbara, Pizzolo, Giovanni, Ferrara, Felicetto, Chiaretti, Sabina, and Foà, Robin

Subjects
Not available, Settore MED/15
Published
2022

49. The bone marrow represents an enrichment site of specific T lymphocytes against filamentous fungi

Author

Vallerini, Daniela, Riva, Giovanni, Barozzi, Patrizia, Forghieri, Fabio, Lagreca, Ivana, Quadrelli, Chiara, Morselli, Monica, Bresciani, Paola, Cuoghi, Angela, Coluccio, Valeria, Maccaferri, Monica, Paolini, Ambra, Colaci, Elisabetta, Marasca, Roberto, Narni, Franco, Latgè, Jean-Paul, Romani, Luigina, Comoli, Patrizia, Campioli, Daniele, Trenti, Tommaso, Luppi, Mario, and Potenza, Leonardo

Published
2016
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50. Preclinical Validation of an Advanced Therapy Medicinal Product Based on Cytotoxic T Lymphocytes Specific for Mutated Nucleophosmin (NPM1 mut) for the Treatment of NPM1 mut -Acute Myeloid Leukemia.

Author

De Cicco, Marica, Lagreca, Ivana, Basso, Sabrina, Barozzi, Patrizia, Muscianisi, Stella, Bianco, Alba, Riva, Giovanni, Di Vincenzo, Sara, Pulvirenti, Chiara, Sapuppo, Davide, Siciliano, Mariangela, Rosti, Vittorio, Candoni, Anna, Zecca, Marco, Forghieri, Fabio, Luppi, Mario, and Comoli, Patrizia

Subjects
CYTOKINES, FLOW cytometry, CLINICAL drug trials, NUCLEOPHOSMIN, GENETIC mutation, MONONUCLEAR leukocytes, HUMAN research subjects, CELLULAR therapy, MANN Whitney U Test, INFORMED consent (Medical law), T-test (Statistics), IMMUNOPHENOTYPING, ENZYME-linked immunosorbent assay, CHI-squared test, DESCRIPTIVE statistics, RESEARCH funding, DRUG development, T cells, CELL surface antigens, HEMATOPOIETIC stem cells, HEMATOPOIETIC stem cell transplantation, DATA analysis software, IMMUNOTHERAPY, IMMUNODIAGNOSIS
Abstract

Simple Summary: Nearly 30% of adult acute myeloid leukemias (AML) harbor mutations of the nucleophosmin (NPM1) gene. These forms have a favorable outcome but, despite notable treatment advances, about 50% of patients still die of progressive disease. Thus, identification of new therapeutic opportunities is important to improve the prognosis. The aim of our study was to assess the feasibility of obtaining a cell therapy medicinal product specific for the mutated NPM1 protein from patients or healthy donors that could be employed to control leukemia and prevent hematologic relapse. We demonstrated that cytotoxic T cells specific for the mutated antigen can be reproducibly expanded, and these cells efficiently recognize and lyse leukemia blasts or other cell types carrying the NPM1-mutated antigen, without causing damage to normal hematopoietic cells. We believe that these T cells may integrate other therapy options in the treatment of patients with refractory or relapsed AML. Acute myeloid leukemia (AML) with nucleophosmin (NPM1) genetic mutations is the most common subtype in adult patients. Refractory or relapsed disease in unfit patients or after allogeneic hematopoietic stem cell transplantation (allo-HSCT) has a poor prognosis. NPM1-mutated protein, stably expressed on tumor cells but not on normal tissues, may serve as an ideal target for NPM1-mutated AML immunotherapy. The study aim was to investigate the feasibility of producing mutated-NPM1-specific cytotoxic T cells (CTLs) suitable for somatic cell therapy to prevent or treat hematologic relapse in patients with NPM1-mutated AML. T cells were expanded or primed from patient or donor peripheral blood mononuclear cells by NPM1-mutated protein-derived peptides, and tested for leukemia antigen-targeted cytotoxic activity, cytokine production and hematopoietic precursor inhibitory effect. We found that mutated-NPM1-specific CTLs, displaying specific cytokine production and high-level cytotoxicity against patients' leukemia blasts, and limited inhibitory activity in clonogenic assays, could be obtained from both patients and donors. The polyfunctional mutated-NPM1-specific CTLs included both CD8+ and CD4+ T cells endowed with strong lytic capacity. Our results suggest that mutated-NPM1-targeted CTLs may be a useful therapeutic option to control low-tumor burden relapse following conventional chemotherapy in older NPM1-mutated AML patients or eradicate persistent MRD after HSCT. [ABSTRACT FROM AUTHOR]

Published
2023
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