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12 results on '"Freiwan, Abdullah"'

1. Engineering naturally occurring CD7− T cells for the immunotherapy of hematological malignancies

Author

Freiwan, Abdullah, Zoine, Jaquelyn T., Crawford, Jeremy Chase, Vaidya, Abishek, Schattgen, Stefan A., Myers, Jacquelyn A., Patil, Sagar L., Khanlari, Mahsa, Inaba, Hiroto, Klco, Jeffery M., Mullighan, Charles G., Krenciute, Giedre, Chockley, Peter J., Naik, Swati, Langfitt, Deanna M., Mamonkin, Maksim, Obeng, Esther A., Thomas, Paul G., Gottschalk, Stephen, and Velasquez, M. Paulina

Published
2022
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2. Redox-Regulation of α-Globin in Vascular Physiology

Author

Kiger, Laurent, primary, Keith, Julia, additional, Freiwan, Abdullah, additional, Fernandez, Alfonso G., additional, Tillman, Heather, additional, Isakson, Brant E., additional, Weiss, Mitchell J., additional, and Lechauve, Christophe, additional

Published
2022
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3. Engineering naturally occurring CD7−T cells for the immunotherapy of hematological malignancies

Author

Freiwan, Abdullah, Zoine, Jaquelyn T., Crawford, Jeremy Chase, Vaidya, Abishek, Schattgen, Stefan A., Myers, Jacquelyn A., Patil, Sagar L., Khanlari, Mahsa, Inaba, Hiroto, Klco, Jeffery M., Mullighan, Charles G., Krenciute, Giedre, Chockley, Peter J., Naik, Swati, Langfitt, Deanna M., Mamonkin, Maksim, Obeng, Esther A., Thomas, Paul G., Gottschalk, Stephen, and Velasquez, M. Paulina

Abstract

•Naturally occurring CD7 negative T cells are functional effector T cells that can be used for chimeric antigen receptor therapy.•CD7 negative T cells expressing a CD7-CAR have robust antitumor activity and bypass fratricide.

Published
2022
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4. Multi-Omic Based Antigen Discovery for the Immunotherapy of Pediatric Acute T Cell Lymphoblastic Leukemia

Author

Hebbar, Nikhil, primary, Qu, Chunxu, additional, Wang, Hong, additional, Shao, Ying, additional, Nguyen, Phuong, additional, Freiwan, Abdullah, additional, Epperly, Rebecca, additional, Li, Yuxin, additional, Cho, Ji-Hoon, additional, Shaw, Timothy, additional, Peng, Junmin, additional, Easton, John, additional, Gottschalk, Stephen, additional, Mullighan, Charles G, additional, and Velasquez, Mireya Paulina, additional

Published
2020
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6. The autophagy-activating kinase ULK1 mediates clearance of free α-globin in β-thalassemia

Author

Lechauve, Christophe, primary, Keith, Julia, additional, Khandros, Eugene, additional, Fowler, Stephanie, additional, Mayberry, Kalin, additional, Freiwan, Abdullah, additional, Thom, Christopher S., additional, Delbini, Paola, additional, Romero, Emilio Boada, additional, Zhang, Jingjing, additional, Motta, Irene, additional, Tillman, Heather, additional, Cappellini, M. Domenica, additional, Kundu, Mondira, additional, and Weiss, Mitchell J., additional

Published
2019
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7. Activation of ULK1 Kinase Mediates Clearance of Free Alpha-Globin in Human Beta-Thalassemic Erythroblasts

Author

Lechauve, Christophe, primary, Keith, Julia, additional, Khandros, Eugene, additional, Fowler, Stephanie, additional, Mayberry, Kalin, additional, Freiwan, Abdullah, additional, Thom, Christopher, additional, Zhang, Jingjing, additional, Tillman, Heather, additional, Kundu, Mondira, additional, Motta, Irene, additional, Cappellini, Maria Domenica, additional, and Weiss, Mitchell J., additional

Published
2018
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8. Unc 51–like autophagy-activating kinase (ULK1) mediates clearance of free α-globin in β-thalassemia

Author

Lechauve, Christophe, primary, Keith, Julia, additional, Khandros, Eugene, additional, Fowler, Stephanie, additional, Mayberry, Kalin, additional, Freiwan, Abdullah, additional, Thom, Christopher S., additional, Delbini, Paola, additional, Romero, Emilio Boada, additional, Zhang, Jingjing, additional, Motta, Irene, additional, Tillman, Heather, additional, Cappellini, M. Domenica, additional, Kundu, Mondira, additional, and Weiss, Mitchell J., additional

Published
2018
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9. Endothelial cell α-globin and its molecular chaperone α-hemoglobin–stabilizing protein regulate arteriolar contractility

Author

Lechauve, Christophe, primary, Butcher, Joshua T., additional, Freiwan, Abdullah, additional, Biwer, Lauren A., additional, Keith, Julia M., additional, Good, Miranda E., additional, Ackerman, Hans, additional, Tillman, Heather S., additional, Kiger, Laurent, additional, Isakson, Brant E., additional, and Weiss, Mitchell J., additional

Published
2018
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12. Elucidating the effects of TCDD on the polymorphic human hs1,2 enhancer .

Author

Freiwan, Abdullah

Subjects
Immunology, Microbiology, TCDD, human hs1,2, B-cellstimulation
Abstract

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a potent environmental toxin known to inhibitimmunoglobulin (Ig) gene expression in various animal studies. We have identified the mouse3’Ig heavy chain regulatory region (3’IgH RR) as a sensitive transcriptional target of TCDD,which may mediate the inhibitory effect of TCDD on Ig expression. Interestingly, the humanhs1,2 enhancer is polymorphic and has been associated with a number of autoimmune diseases.Suggesting a species difference, TCDD inhibited mouse hs1,2 enhancer activation and activatedbasal human hs1,2 (hs-hs1,2) enhancer activity in the mouse B-cell line. The objective of thisstudy was to elucidate the effects of TCDD on the polymorphic human hs1,2 enhancer using ahuman B-cell line (CL-01) and luciferase reporter constructs regulated by each of the humanhs1,2 alleles. Our results verify that TCDD alone activates each of the hu-hs1,2 alleles.Surprisingly, B-cell stimulation through the Toll-like receptors (TLR) 7, 8, and 9, and the AhRantagonist inhibited basal activity of the hu-hs1,2 alleles and TCDD co-treatment reversed TLR-inducedinhibition. Contrary to this, TLR stimulates IgM secretion as well as class switching toIgG secretion. These results suggest that the hu-hs1,2 enhancer may be a negative regulator of3’IgH RR activity and Ig expression.

Published
2014

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