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2. Lifetime spirometry patterns of obstruction and restriction, and their risk factors and outcomes: a prospective cohort study

Author

Dharmage, Shyamali C, Bui, Dinh S, Walters, Eugene H, Lowe, Adrian J, Thompson, Bruce, Bowatte, Gayan, Thomas, Paul, Garcia-Aymerich, Judith, Jarvis, Debbie, Hamilton, Garun S, Johns, David P, Frith, Peter, Senaratna, Chamara V, Idrose, Nur S, Wood-Baker, Richard R, Hopper, John, Gurrin, Lyle, Erbas, Bircan, Washko, George R, Faner, Rosa, Agusti, Alvar, Abramson, Michael J, Lodge, Caroline J, and Perret, Jennifer L

Published
2023
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4. Effects of combined tiotropium/olodaterol on inspiratory capacity and exercise endurance in COPD.

Author

O'Donnell, Denis E, Casaburi, Richard, Frith, Peter, Kirsten, Anne, De Sousa, Dorothy, Hamilton, Alan, Xue, Wenqiong, and Maltais, François

Subjects
Humans, Pulmonary Disease, Chronic Obstructive, Benzoxazines, Bronchodilator Agents, Drug Combinations, Inspiratory Capacity, Forced Expiratory Volume, Cross-Over Studies, Double-Blind Method, Nebulizers and Vaporizers, Exercise Tolerance, Adult, Aged, Middle Aged, Female, Male, Tiotropium Bromide, Pulmonary Disease, Chronic Obstructive, Respiratory System, Medical and Health Sciences
Abstract

Two replicate, double-blind, 6-week, incomplete-crossover studies (MORACTO 1 and 2) assessed the effects of tiotropium/olodaterol on inspiratory capacity and exercise endurance time in patients with moderate to severe chronic obstructive pulmonary disease.For each patient, four of five treatments were administered once daily for 6 weeks, with a 21-day washout between treatments: tiotropium/olodaterol 2.5/5 µg or 5/5 µg, tiotropium 5 µg, olodaterol 5 µg or placebo, all via the Respimat inhaler. Primary outcomes were inspiratory capacity prior to exercise and exercise endurance time during constant work-rate cycle ergometry to symptom limitation at 75% of peak incremental work rate after 6 weeks (2 h post-dose).295 and 291 patients were treated in MORACTO 1 and 2, respectively. Tiotropium/olodaterol 2.5/5 and 5/5 µg provided significant improvements in inspiratory capacity versus placebo and monotherapies (p

Published
2017

6. Can We Use Lung Function Thresholds and Respiratory Symptoms to Identify Pre-COPD? A Prospective, Population-based Cohort Study

Author

Tan, Daniel J, primary, Lodge, Caroline J., additional, Walters, E. Haydn, additional, Bui, Dinh S., additional, Pham, Jonathan, additional, Lowe, Adrian J., additional, Bowatte, Gayan, additional, Vicendese, Don, additional, Erbas, Bircan, additional, Johns, David P, additional, James, Alan L, additional, Frith, Peter, additional, Hamilton, Garun S, additional, Thomas, Paul S, additional, Wood-Baker, Richard, additional, Han, MeiLan K., additional, Washko, George R, additional, Abramson, Michael J, additional, Perret, Jennifer L., additional, and Dharmage, Shaymali C., additional

Published
2024
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7. Can We Use Lung Function Thresholds and Respiratory Symptoms to Identify Pre-Chronic Obstructive Pulmonary Disease? A Prospective, Population-based Cohort Study.

Author

Tan, Daniel J., Lodge, Caroline J., Walters, E. Haydn, Bui, Dinh S., Pham, Jonathan, Lowe, Adrian J., Bowatte, Gayan, Vicendese, Don, Erbas, Bircan, Johns, David P., James, Alan L., Frith, Peter, Hamilton, Garun S., Thomas, Paul S., Wood-Baker, Richard, Han, MeiLan K., Washko, George R., Abramson, Michael J., Perret, Jennifer L., and Dharmage, Shyamali C.

Subjects
LUNG diseases, LUNGS, COHORT analysis, MIDDLE-aged persons, LUNG volume
Abstract

Rationale: The term "pre–chronic obstructive pulmonary disease" ("pre-COPD") refers to individuals at high risk of developing COPD who do not meet conventional spirometric criteria for airflow obstruction. New approaches to identifying these individuals are needed, particularly in younger populations. Objectives: To determine whether lung function thresholds and respiratory symptoms can be used to identify individuals at risk of developing COPD. Methods: The Tasmanian Longitudinal Health Study comprises a population-based cohort first studied in 1968 (at age 7 yr). Respiratory symptoms, pre- and post-bronchodilator (BD) spirometry, diffusing capacity, and static lung volumes were measured in a subgroup at age 45, and the incidence of COPD was assessed at age 53. For each lung function measure, z-scores were calculated using Global Lung Function Initiative references. The optimal threshold for best discrimination of COPD incidence was determined by the unweighted Youden index. Measurements and Main Results: Among 801 participants who did not have COPD at age 45, the optimal threshold for COPD incidence by age 53 was pre-BD FEV1/FVC z-score less than −1.264, corresponding to the lowest 10th percentile. Those below this threshold had a 36-fold increased risk of developing COPD over an 8-year follow-up period (risk ratio, 35.8; 95% confidence interval, 8.88 to 144), corresponding to a risk difference of 16.4% (95% confidence interval, 3.7 to 67.4). The sensitivity was 88%, and the specificity was 87%. Positive and negative likelihood ratios were 6.79 and 0.14, respectively. Respiratory symptoms, post-BD spirometry, diffusing capacity, and static lung volumes did not improve on the classification achieved by pre-BD FEV1/FVC alone. Conclusions: This is the first study, to our knowledge, to evaluate the discriminatory accuracy of spirometry, diffusing capacity, and static lung volume thresholds for COPD incidence in middle-aged adults. Our findings support the inclusion of pre-BD spirometry in the physiological definition of pre-COPD and indicate that pre-BD FEV1/FVC at the 10th percentile accurately identifies individuals at high risk of developing COPD in community-based settings. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Childhood predictors of lung function trajectories and future COPD risk: a prospective cohort study from the first to the sixth decade of life

Author

Bui, Dinh S, Lodge, Caroline J, Burgess, John A, Lowe, Adrian J, Perret, Jennifer, Bui, Minh Q, Bowatte, Gayan, Gurrin, Lyle, Johns, David P, Thompson, Bruce R, Hamilton, Garun S, Frith, Peter A, James, Alan L, Thomas, Paul S, Jarvis, Deborah, Svanes, Cecilie, Russell, Melissa, Morrison, Stephen C, Feather, Iain, Allen, Katrina J, Wood-Baker, Richard, Hopper, John, Giles, Graham G, Abramson, Michael J, Walters, Eugene H, Matheson, Melanie C, and Dharmage, Shyamali C

Published
2018
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9. Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary

Author

Vogelmeier, Claus F., Criner, Gerard J., Martinez, Fernando J., Anzueto, Antonio, Barnes, Peter J., Bourbeau, Jean, Celli, Bartolome R., Chen, Rongchang, Decramer, Marc, Fabbri, Leonardo M., Frith, Peter, Halpin, David M.G., Varela, M. Victorina López, Nishimura, Masaharu, Roche, Nicolas, Rodriguez-Roisin, Roberto, Sin, Don D., Singh, Dave, Stockley, Robert, Vestbo, Jørgen, Wedzicha, Jadwiga A., and Agusti, Alvar

Published
2017
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10. Informe 2017 de la Iniciativa Global para el Diagnóstico, Tratamiento y Prevención de la Enfermedad Pulmonar Obstructiva Crónica: Resumen Ejecutivo de GOLD

Author

Vogelmeier, Claus F., Criner, Gerard J., Martínez, Fernando J., Anzueto, Antonio, Barnes, Peter J., Bourbeau, Jean, Celli, Bartolome R., Chen, Rongchang, Decramer, Marc, Fabbri, Leonardo M., Frith, Peter, Halpin, David M.G., López Varela, M. Victorina, Nishimura, Masaharu, Roche, Nicolás, Rodríguez-Roisin, Roberto, Sin, Don D., Singh, Dave, Stockley, Robert, Vestbo, Jørgen, Wedzicha, Jadwiga A., and Agustí, Alvar

Published
2017
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12. Pulmonary Rehabilitation with and without a Cognitive Behavioral Intervention for Breathlessness in People Living with Chronic Obstructive Pulmonary Disease: Randomized Controlled Trial.

Author

Williams, Marie T., Lewthwaite, Hayley, Paquet, Catherine, Cafarella, Paul, and Frith, Peter

Subjects
CHRONIC obstructive pulmonary disease, RANDOMIZED controlled trials, COGNITIVE therapy, DYSPNEA, COGNITIVE rehabilitation, PEDOMETERS, NEUROPSYCHOLOGICAL rehabilitation
Abstract

(1) Background: Most controlled trials of cognitive behavior therapy (CBT) in people living with chronic obstructive pulmonary disease (COPD) have targeted anxiety and depression. (2) Methods: This pragmatic randomized controlled trial explored whether a comprehensive pulmonary rehabilitation program (CPRP) with CBT for breathlessness or social group control (CPRP + SC) significantly improved health outcomes. (3) Results: People with moderate-to-severe COPD were block randomized (CPRP + CBT n = 52 or CPRP + SC n = 49). Primary outcomes (Hospital Anxiety and Depression scale (HADs), six-minute walk distance (6MWD)) and secondary outcomes (breathlessness, quality of life and habitual physical activity) were assessed before and 1, 6 and 12 months post intervention. Between-group differences were calculated with mixed models for each time point to baseline (intention to treat (ITT)). Participants (n = 101, mean ± SD age 70 ± 8.5 years, 54 (53%) males, FEV1% pred 47.7 ± 16.3) were similar between groups. Post intervention, primary outcomes did not differ significantly between groups at 1 (6MWD mean difference −7.5 [95% CI −34.3 to 19.4], HADs-A −0.3 [−1.4 to 0.9], HADs-D 0.2 [−0.8 to 1.3]), 6 (6MWD −11.5 [−38.1 to 15.1], HADs-A 1.1 [0.0 to 2.2], HADs-D 0.2 [−0.9 to 1.3]), or 12 months (6MWD −3.8 [−27.2 to 19.6], HADS-A −0.4 [−1.5 to 0.6], HADs-D −0.7 [−1.7 to 0.4]). (4) Conclusions: In this cohort, combining CBT with a CPRP did not provide additional health benefits beyond those achieved by a standard CPRP. [ABSTRACT FROM AUTHOR]

Published
2023
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13. Lifetime spirometry patterns of obstruction and restriction, and their risk factors and outcomes: a prospective cohort study

Author

Dharmage, Shyamali C, primary, Bui, Dinh S, additional, Walters, Eugene H, additional, Lowe, Adrian J, additional, Thompson, Bruce, additional, Bowatte, Gayan, additional, Thomas, Paul, additional, Garcia-Aymerich, Judith, additional, Jarvis, Debbie, additional, Hamilton, Garun S, additional, Johns, David P, additional, Frith, Peter, additional, Senaratna, Chamara V, additional, Idrose, Nur S, additional, Wood-Baker, Richard R, additional, Hopper, John, additional, Gurrin, Lyle, additional, Erbas, Bircan, additional, Washko, George R, additional, Faner, Rosa, additional, Agusti, Alvar, additional, Abramson, Michael J, additional, Lodge, Caroline J, additional, and Perret, Jennifer L, additional

Published
2022
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22. Ten-year prediction model for post-bronchodilator airflow obstruction and early detection of COPD: development and validation in two middle-aged population-based cohorts

Author

Perret, Jennifer L, primary, Vicendese, Don, additional, Simons, Koen, additional, Jarvis, Debbie L, additional, Lowe, Adrian J, additional, Lodge, Caroline J, additional, Bui, Dinh S, additional, Tan, Daniel, additional, Burgess, John A, additional, Erbas, Bircan, additional, Bickerstaffe, Adrian, additional, Hancock, Kerry, additional, Thompson, Bruce R, additional, Hamilton, Garun S, additional, Adams, Robert, additional, Benke, Geza P, additional, Thomas, Paul S, additional, Frith, Peter, additional, McDonald, Christine F, additional, Blakely, Tony, additional, Abramson, Michael J, additional, Walters, E Haydn, additional, Minelli, Cosetta, additional, and Dharmage, Shyamali C, additional

Published
2021
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25. Glycopyrronium once-daily significantly improves lung function and health status when combined with salmeterol/fluticasone in patients with COPD: the GLISTEN study—a randomised controlled trial

Author

Frith, Peter A, Thompson, Philip J, Ratnavadivel, Rajeev, Chang, Catherina L, Bremner, Peter, Day, Peter, Frenzel, Christina, Kurstjens, Nicol, Waddell, Ainslie, Daniel, Alexander, Khoussousi, Alireza, Springfield, Andrew, Veale, Andrew, Graham, Anthony Neil, Gallagher, Brad, Pande, Braj Raj, OʼKane, Brendan, Jones, Christopher, Baldi, Claudio, Helm, Colin, OʼDochartaigh, Conor, Chambers, Daniel, Quinn, Dean, Yull, Derek, Karthigesu, Dhanalakshi, Then, Edward, Graham, Frank, Faigenbaum, Fred, Geddam, Geetha, Cameron, Gillian, Blom, Hans, Goldman, Hershel, Snell, Hilary, Chia, Imagard, Jeong, James, Liew, James, Salvaris, James, Pryke, Jason, Reid, Jim, Kolbe, John, OʼSullivan, John, Pak, John, Upham, John, Feiber, Joseph, Ford, Judith OʼMalley, Yong, Kevin, Perrin, Kyle, Noonan, Lawrence, Atlas, Len, Murdoch, Louise, Pearce, Margaret, Bloch, Mark, Holmes, Mark, Chia, Michael, Epton, Michael, Leadston, Michelle, Tandon, MK, Chitgopeker, Mohan, Liebenberg, Naomi, Hendry, Neil, Olaniyi, Olakunle, Singh, Omesh, Kendall, Peter, Van Niekerk, Peter, Willet, Rodney, Tomlins, Ronald, Pillay, Salven, Sharifeh, Sammy, Carson, Simon, Bingham, Stephen, Walford, Ted, Erasmus, Tersia, Claridge, Trevor, and Hess, Zofia

Published
2015
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27. Lifetime spirometric patterns of obstruction and restriction: risk factors and outcomes

Author

Dharmage, Shyamali, primary, Bui, Dinh, additional, Walters, Haydn, additional, Lowe, Andrian, additional, Thompson, Bruce, additional, Thomas, Paul, additional, Garcia-Aymerich, Judith, additional, Hamilton, Garun, additional, John, Davids, additional, Frith, Peter, additional, Faner, Rosa, additional, Agusti, Alvar, additional, Abramson, Michael, additional, Perret, Jennifer, additional, and Lodge, Caroline, additional

Published
2021
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29. Lung function trajectory and biomarkers in the Tasmanian Longitudinal Health Study

Author

Bui, Dinh S., primary, Agusti, Alvar, additional, Walters, Haydn, additional, Lodge, Caroline, additional, Perret, Jennifer L., additional, Lowe, Adrian, additional, Bowatte, Gayan, additional, Cassim, Raisa, additional, Hamilton, Garun S., additional, Frith, Peter, additional, James, Alan, additional, Thomas, Paul S., additional, Jarvis, Debbie, additional, Abramson, Michael J., additional, Faner, Rosa, additional, and Dharmage, Shyamali C., additional

Published
2021
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35. Exposure to household air pollution over 10 years is related to asthma and lung function decline

Author

Dai, Xin, primary, Bui, Dinh S., additional, Perret, Jennifer L., additional, Lowe, Adrian J., additional, Frith, Peter A., additional, Bowatte, Gayan, additional, Thomas, Paul S., additional, Giles, Graham G., additional, Hamilton, Garun S., additional, Tsimiklis, Helen, additional, Hui, Jennie, additional, Burgess, John, additional, Win, Aung K., additional, Abramson, Michael J., additional, Walters, E. Haydn, additional, Dharmage, Shyamali C., additional, and Lodge, Caroline J., additional

Published
2020
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38. Response

Author

Williams, Marie Therese, Olds, Timothy, Petkov, John, Cafarella, Paul, and Frith, Peter

Published
2009
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42. Pragmatic randomised controlled trial of a personalised intervention for carers of people requiring home oxygen therapy

Author

Frith, Peter, Sladek, Ruth, Woodman, Richard, Effing, Tanja, Bradley, Sandra, van Asten, Suzanne, Jones, Tina, Hnin, Khin, Luszcz, Mary, Cafarella, Paul, Eckermann, Simon, Rowett, Debra, Phillips, Paddy, Frith, Peter, Sladek, Ruth, Woodman, Richard, Effing, Tanja, Bradley, Sandra, van Asten, Suzanne, Jones, Tina, Hnin, Khin, Luszcz, Mary, Cafarella, Paul, Eckermann, Simon, Rowett, Debra, and Phillips, Paddy

Abstract

© The Author(s) 2020. We used a pragmatic randomised controlled trial to evaluate a behavioural change strategy targeting carers of chronically hypoxaemic patients using long-term home oxygen therapy. Intervention group carers participated in personalised educational sessions focusing on motivating carers to take actions to assist patients. All patients received usual care. Effectiveness was measured through a composite event of patient survival to hospitalisation, residential care admission or death to 12 months. Secondary outcomes at baseline, 3, 6 and 12 months included carer and patient emotional and physical well-being. No difference between intervention (n = 100) and control (n = 97) patients was found for the composite outcome (hazard ratio (HR) 1.22, 95% confidence interval (CI) = 0.89, 1.68; p = 0.22). Improved fatigue, mastery, vitality and general health occurred in intervention group patients (all p values < 0.05). No benefits were seen in carer outcomes. Mortality was significantly higher in intervention patients (HR = 2.01, 95% CI = 1.00, 4.14; p = 0.05; adjusted for Australia-modified Karnofsky Performance Status), with a significant diagnosis–intervention interaction (p = 0.028) showing higher mortality in patients with COPD (HR 4.26; 95% CI = 1.60, 11.35) but not those with interstitial lung disease (HR 0.83; 95% CI = 0.28, 2.46). No difference was detected in the primary outcome, but patient mortality was higher when carers had received the intervention, especially in the most disabled patients. Trials examining behavioural change interventions in severe disease should stratify for functionality, and both risks and benefits should be independently monitored. Trial registration: Australian New Zealand Clinical Trials Registry (ACTRN12607000177459).

Published
2020

43. COPDX: An update of guidelines for the management of chronic obstructive pulmonary disease with a review of recent evidence

Author

Abramson, Michael J., Crockett, Alan J., Frith, Peter A., and McDonald, Christine F.

Subjects
Lung diseases, Obstructive -- Care and treatment, Medical societies -- Standards, Practice guidelines (Medicine), Health
Abstract

Chronic obstructive pulmonary disease (COPD), a major public health problem is a single leading cause of death that is continuing to increase and has become the third largest contributor to the burden of disease in Australia. For this purpose the Australian Lung Foundation and Thoracic Society of Australia and New Zealand developed a clinical practice guidelines (COPDX) to improve the diagnosis and management of COPD.

Published
2006

48. The COPDX Plan: Australian and New Zealand Guidelines for the management of Chronic Obstructive Pulmonary Disease 2003

Author

McKenzie, David K., Frith, Peter A., Burdon, Jonathan G.W., and Town, G. Ian

Subjects
Lung diseases, Obstructive -- Research, Lung diseases, Obstructive -- Care and treatment, Health
Abstract

This supplement contains the report of a committee concerning the treatment of chronic obstructive pulmonary disease (COPD). The COPDX guidelines include Confirmation of the diagnosis, Optimization of lung function, Prevention of deterioration, Developing a support network and self-management plan, and managing eXacerbations. The supplement provides an in-depth look at each stage.

Published
2003

49. The effectiveness of coordinated care for people with chronic respiratory disease

Author

Smith, Brian J., McElroy, Heather J., Ruffin, Richard E., Frith, Peter A., Heard, Adrian R., Battersby, Malcolm W., Esterman, Adrian J., Fante, Peter Del, and McDonald, Peter J.

Subjects
Respiratory disease nursing -- Influence, Respiratory tract diseases -- Care and treatment, Health
Abstract

A control study of patients with acute respiratory conditions living in western and northern Adelaide, Australia, was conducted in 1999 to determine if coordinated care would reduce the need for hospitalization. The results of the study suggest that coordinated care given to patients with chronic respiratory disease did not affect hospitalisation and are associated with an improvement in some quality-of-life measures.

Published
2002

50. Automated attention flags in chronic disease care planning

Author

Warren, James R., Noone, Joseph T., Smith, Brian J., Ruffin, Richard, Frith, Peter, van der Zwaag, Berend J., Beliakov, Gleb V., Frankel, Heath K., and McElroy, Heather J.

Subjects
Decision support systems -- Evaluation, Diseases -- Care and treatment, Respiratory disease nursing -- Practice, Health
Abstract

An investigated is conducted into the value of automated decision support in the management of chronic respiratory disease. A comparison is made of the agreements of three respiratory specialists. It is seen that computerised decision support can allow GPs improved access to the intent of guidelines.

Published
2001

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