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2. Regular football training down-regulates miR-1303 muscle expression in veterans

Author

F. M. Orlandella, Daniela Vitucci, Peter Krustrup, Stefania Orrù, G. Salvatore, Pasqualina Buono, E. Grazioli, Esther Imperlini, R. M. Mariniello, Annamaria Mancini, and A. Terracciano

Subjects
0301 basic medicine, Male, Physiology, Longevity, Football, Down-Regulation, BAG-2, Biology, 03 medical and health sciences, 0302 clinical medicine, Western blot, Physiology (medical), microRNA, Soccer, medicine, Autophagy, Myocyte, Humans, Orthopedics and Sports Medicine, miR-1303, Muscle, Skeletal, Gene, Exercise, Aged, Veterans, medicine.diagnostic_test, Public Health, Environmental and Occupational Health, Skeletal muscle, General Medicine, Cell biology, MicroRNAs, 030104 developmental biology, medicine.anatomical_structure, Football training, 030220 oncology & carcinogenesis, Gene chip analysis, Original Article
Abstract

Purpose Regular exercise affects the expression of several genes, proteins and microRNAs (miRNAs) in time- and intensity-dependent manner promoting longevity. We previously identified from GeneChip Array analysis several differentially expressed genes and miRNAs in muscle from veteran football players (VPG) compared to active untrained elderly subjects (CG); here we focussed on miRNA-1303 (miR-1303). The aims of the present research were: to analyse the effects of football training on the expression of miR-1303 and to identify its putative target involved in the longevity pathways in skeletal muscle from VPG compared to CG. Methods RNA samples from 12 VPG and 12 CG muscle biopsies were used to validate miR-1303 expression. Crossing four different bioinformatic algorithms, we identified 16 putative targets of miR-1303; from these, BAG-2, KLHL7 and KBTBD6 were chosen for further validation by Western blot analysis in LHCN-M2 human myoblasts transiently transfected with miR-1303. Results Football training down-regulates miR-1303 expression in muscle from VPG compared to CG and the expression of BAG-2, a chaperon protein involved in the autophagy pathway, inversely correlated to overexpression of miR-1303 in a time-dependent manner, indicating that it is a miR-1303 potential target. Conclusions This is the first report, to our knowledge, describing miR-1303 regulation in skeletal muscle by football training and the identification of a target protein, BAG-2, involved in the autophagy pathway. This result contributes to the enlargement of knowledge on the molecular mechanisms linking football training, autophagy and longevity.

Published
2021
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3. Tumor-associated macrophages (TAMs) modulate response to HER2-targeted agents in a humanized mouse model of breast cancer

Author

M, Loi, G, Salvatore, M, Sottili, L, Calosi, I, Desideri, C, Becherini, V, Salvestrini, L P, Ciccone, G, Stocchi, I, Meattini, G, Francolini, M, Mangoni, and L, Livi

Subjects
Mice, Paclitaxel, Receptor, ErbB-2, Cell Line, Tumor, Tumor-Associated Macrophages, Animals, Humans, Antineoplastic Agents, Breast Neoplasms, Female, Clodronic Acid, Trastuzumab
Abstract

Tumor-associated macrophages (TAM) may participate to antitumor activity of anti-HER2-targeted therapies (Pertuzumab, Trastuzumab) in breast cancers harbouring HER-2 overexpression through antibody-dependent phagocytosis. Additive antitumor effect of concurrent cytotoxic chemotherapies, including Paclitaxel, may be counterbalanced by alteration in TAM infiltrate. The aim of this study is to evaluate the role of TAM in tumor response to anti-HER2-targeted therapies and chemotherapy in an experimental model of HER2-amplified breast cancer.A xenograft mouse model was built by subcutaneous injection of the SKBR-3 human HER2-amplified breast cancer cell line in Hu-CD34+ mice. Animals were randomized to receive weekly administration of Cremophor (control), Trastuzumab+Pertuzumab (TP), and Paclitaxel+Trastuzumab+Pertuzumab (PTP) with or without macrophage depletion with clodronate (C). At week 4, mice were euthanised and tumors were harvested for immunohistochemical analysis of TAM infiltration (RBP-J CD163 and CD68 for M1, M2, and overall TAM, respectively).Tumor size was significantly lower in mice treated with TP, PTP, and PTP+C as compared to control, while no meaningful difference was observed in the TP+C arm. Analysis of TAM infiltrate showed significantly lower CD68 and CD163 expression in PTP, TP+C, and PTP+C as compared to TP and control arm. RBP-J expression was significantly decreased in mice treated with clodronate depletion.Activity of TP is modulated by TAM infiltrate, that is inhibited by concurrent administration of Paclitaxel. To enhance the effect of anti-HER2-targeted therapies and minimize chemotherapy-related side effects, modulation of TAM should be considered in novel therapeutic combinations.

Published
2021

5. In response to the FDA warning about the use of photomedicine in gynecology

Author

Escribano, J.J. González-Isaza, P. Tserotas, K. Athanasiou, S. Zerbinati, N. Leibaschoff, G. Salvatore, S. Sánchez-Borrego, R.

Abstract

To alert patients and health care providers about the use of energy-based devices to perform a vaginal “rejuvenation,” cosmetic vaginal procedures, or nonsurgical vaginal procedures to treat symptoms related to menopause, urinary incontinence, or sexual function, the US Food and Drug Administration (FDA) has issued a warning about the effectiveness and safety of such devices. We agree with the FDA that certain devices (laser, radiofrequency, etc.) have been marketed inappropriately for uses that are outside of their cleared or approved intended uses. We want to position ourselves in the strict training of professionals so that the indications and techniques are used in the best possible way, knowing that, similar to any medical or surgical technique, the side effects can appear in the short and long term, and should be recognized and remedied. © 2019, Springer-Verlag London Ltd., part of Springer Nature.

Published
2019

6. A Review of Bovine Urothelial Tumours and Tumour-Like Lesions of the Urinary Bladder

Author

Sante Roperto, Giuseppe Borzacchiello, G. Salvatore, Orlando Paciello, Chiara Urraro, R. Brun, Valentina Russo, Manuela Martano, Paola Maiolino, Brunella Restucci, Franco Roperto, Serenella Papparella, Leonardo Leonardi, Roperto, Sante, Borzacchiello, Giuseppe, R., Brun, L., Leonardi, Maiolino, Paola, Martano, Manuela, Paciello, Orlando, Papparella, Serenella, Restucci, Brunella, Russo, Valeria, G., Salvatore, Urraro, Chiara, and Roperto, FRANCO PEPPINO

Subjects
Pathology, medicine.medical_specialty, Cattle Diseases, urothelial tumors, medicine.disease_cause, papillomavirus, World health, Pathology and Forensic Medicine, Lesion, medicine, Carcinoma, Animals, Bovine papillomavirus, Urinary bladder, Papilloma, General Veterinary, biology, Carcinoma in situ, cattle, medicine.disease, biology.organism_classification, Carcinoma, Papillary, medicine.anatomical_structure, Urinary Bladder Neoplasms, Urothelium, medicine.symptom, Carcinogenesis, Carcinoma in Situ
Abstract

Four hundred bovine urothelial tumours and tumour-like lesions were classified in accordance with the 2004 World Health Organization (WHO) morphological classification for human urothelial tumours. The spectrum of neoplastic lesions of the urinary bladder of cattle is becoming wider and bovine urothelial tumours share striking morphological features with their human counterparts. A classification system based on the WHO scheme would also be appropriate for the classification of bovine bladder tumours. Bovine urothelial tumours are most often multiple. Four distinct growth patterns of bovine urothelial tumours and tumour-like lesions are recognized: flat, exophytic or papillary, endophytic and invasive. Carcinoma in situ (CIS) is the most common flat urothelial lesion, accounting for approximately 4% of urothelial tumours. CIS is detected adjacent to papillary and invasive tumours in 80-90% of cases. Approximately 3% of papillary lesions are papillomas and approximately 5% are 'papillary urothelial neoplasms of low malignant potential' (PUNLMP). Low-grade carcinoma is the most common urothelial tumour of cattle. High-grade carcinomas, and low and high-grade invasive tumours, are less commonly seen. Bovine papillomavirus (BPV) infection and ingestion of bracken fern both play a central role in carcinogenesis of these lesions.

Published
2010
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9. Prognostic Impact of Diabetes and Prediabetes on Survival Outcomes in Patients With Chronic Heart Failure: A Post-Hoc Analysis of the GISSI-HF (Gruppo Italiano per lo Studio della Sopravvivenza nella Insufficienza Cardiaca-Heart Failure) Trial

Author

Marco Dauriz, Giovanni Targher, Pier Luigi Temporelli, Donata Lucci, Lucio Gonzini, Gian Luigi Nicolosi, Roberto Marchioli, Gianni Tognoni, Roberto Latini, Franco Cosmi, Luigi Tavazzi, Aldo Pietro Maggioni, Simona Barlera, Maria Grazia Franzosi, Aldo P. Maggioni, Maurizio Porcu, Salim Yusuf, Fulvio Camerini, Jay N. Cohn, Adriano Decarli, Bertram Pitt, Peter Sleight, Philip A. Poole‐Wilson, Enrico Geraci, Marino Scherillo, Gianna Fabbri, Barbara Bartolomei, Daniele Bertoli, Franco Cobelli, Claudio Fresco, Antonietta Ledda, Giacomo Levantesi, Cristina Opasich, Franco Rusconi, Gianfranco Sinagra, Fabio Turazza, Alberto Volpi, Martina Ceseri, Gianluca Alongi, Antonio Atzori, Filippo Bambi, Desiree Bastarolo, Francesca Bianchini, Iacopo Cangioli, Vittoriana Canu, Concetta Caporusso, Gabriele Cenni, Laura Cintelli, Michele Cocchio, Alessia Confente, Eva Fenicia, Giorgio Friso, Marco Gianfriddo, Gianluca Grilli, Beatrice Lazzaro, Giuseppe Lonardo, Alessia Luise, Rachele Nota, Mariaelena Orlando, Rosaria Petrolo, Chiara Pierattini, Valeria Pierota, Alessandro Provenzani, Velia Quartuccio, Anna Ragno, Chiara Serio, Alvise Spolaor, Arianna Tafi, Elisa Tellaroli, Stefano Ghio, Elisa Ghizzardi, Serge Masson, Lella Crociati, Maria Teresa La Rovere, Ugo Corrà, Andrea Finzi, Marco Gorini, Valentina Milani, Giampietro Orsini, Elisa Bianchini, Silvia Cabiddu, Ilaria Cangioli, Laura Cipressa, Maria Lucia Cipressa, Giuseppina Di Bitetto, Barbara Ferri, Luisa Galbiati, Andrea Lorimer, Carla Pera, Paola Priami, Antonella Vasamì, T. Moccetti, M.G. Rossi, E. Pasotti, F. Vaghi, P. Roncarolo, M.T. Zunino, F. Matta, E. Actis Perinetto, F. Gaita, G. Azzaro, M. Zanetta, A.M. Paino, U. Parravicini, D. Vegis, R. Conte, P. Ferraro, A. De Bernardi, S. Morelloni, M. Fagnani, P. Greco Lucchina, L. Montagna, E. Bellone, D. Sappè, F. Ferraro, M. Delucchi, S.G. Reynaud, M. Dore, A. La Brocca, N. Massobrio, L. Bo, R. Trinchero, M. Imazio, G. Brocchi, A. Nejrotti, L. Rissone, S. Gabasio, C. Zocchi, S. Randazzo, A. Crenna, P. Giannuzzi, E. Bonanomi, A. Mezzani, M. De Marchi, G. Begliuomini, C.A. Gianonatti, A. Gavazzi, A. Grosu, L. Dei Cas, S. Nodari, P. Garyfallidis, A. Bertoletti, C. Bonifazi, S. Arisi, F. Mascaro, M. Fraccarollo, S. Dell'Orto, M. Sfolcini, F. Bortolini, D. Raccagni, A. Turelli, M. Santarone, E. Miglierina, L. Sormani, R. Jemoli, F. Tettamanti, S. Pirelli, C. Bianchi, S. Verde, M. Mariani, V. Ziacchi, A. Ferrazza, A. Russo, M. Bortolotti, G.F. Pasini, A. Volpi, K.N. Jones, D. Cuzzucrea, G. Gullace, C. Carbone, A. Granata, S. De Servi, G. Del Rosso, C. Inserra, E. Renaldini, C. Zappa, M. Moretti, R. Zanini, M. Ferrari, E. Moroni, A. Cei, C. Lissi, E. Dovico, C. Fiorentini, P. Palermo, B. Brusoni, M. Negrini, J. Heyman, G.B. Danzi, A. Finzi, M. Frigerio, F. Turazza, L. Beretta, A. Sachero, F. Casazza, L. Squadroni, F. Lombardi, L. Marano, A. Margonato, G. Fragasso, O.C. Febo, E. Aiolfi, F. Olmetti, A. Grieco, V. Antonazzo, G. Specchia, A. Mortara, F. Robustelli, M.G. Songini, C. Schweiger, A. Frisinghelli, M. Palvarini, C. Campana, L. Scelsi, N. Ajmone Marsan, F. Cobelli, A. Gualco, C. Opasich, S. De Feo, R. Mazzucco, M.A. Iannone, T. Diaco, D. Zaniboni, G. Milanesi, D. Nassiacos, S. Meloni, P. Giani, T. Nicoli, C. Malinverni, A. Gusmini, L. Pozzoni, G. Bisiani, P. Margaroli, A. Schizzarotto, A. Daverio, G. Occhi, N. Partesana, P. Bandini, M.G. Rosella, S. Giustiniani, G. Cucchi, R. Pedretti, R. Raimondo, R. Vaninetti, A. Fedele, I. Ghezzi, E. Rezzonico, J.A. Salerno Uriarte, F. Morandi, F. Salvucci, C. Valenti, G. Graziano, M. Romanò, C. Cimminiello, I. Mangone, M. Lombardo, P. Quorso, G. Marinoni, M. Breghi, M. Erckert, A. Dienstl, G. Mirante Marini, C. Stefenelli, G. Cioffi, E. Buczkowska, A. Bonanome, F. Bazzanini, L. Parissenti, C. Serafini, G. Catania, L. Tarantini, G. Rigatelli, S. Boni, A. Pasini, E. Masini, A.A. Zampiero, M. Zanchetta, L. Franceschetto, P. Delise, C. Marcon, A. Sacchetta, L. Borgese, L. Artusi, P. Casolino, F. Corbara, A. Banzato, M. Barbiero, M.P. Aldegheri, R. Bazzucco, G. Crivellenti, A. Raviele, C. Zanella, P. Pascotto, P. Sarto, S. Milan, E. Barbieri, P. Girardi, W. Dalla Villa, J. Dalle Mule, M.L. Di Sipio, R. Cazzin, D. Milan, P. Zonzin, M. Carraro, R. Rossi, E. Carbonieri, I. Rossi, P. Stritoni, P. Meneghetti, G. Risica, P.L. Tenderini, C. Vassanelli, L. Zanolla, G. Perini, G. Brighetti, R. Chiozza, G. Giuliano, R. Gortan, R. Cesanelli, G.L. Nicolosi, R. Piazza, L. Mos, O. Vriz, D. Pavan, G. Pascottini, E. Alberti, M. Werren, L. Solinas, G. Sinagra, F. Longaro, P. Fioretti, M.C. Albanese, D. Miani, R. Gianrossi, A. Pende, P. Rubartelli, O. Magaia, S. Domenicucci, D. Caruso, A.S. Faraguti, L. Magliani, F. Miccoli, G. Guglielmino, D. Bertoli, A. Cantarelli, S. Orlandi, A. Vallebona, A. Pozzati, G. Brega, L.G. Pancaldi, R. Vandelli, S. Urbinati, M.G. Poci, M. Zoli, G.M. Costa, U. Guiducci, G. Zobbi, F. Tartagni, A. Tisselli, A. Gentili, P. Pieri, E. Cagnetta, S. Bendinelli, A. Barbieri, R. Conti, R. Ferrari, F. Merlini, A. Fucili, P. Moruzzi, E. Buia, M. Galvani, D. Ferrini, G. Baggioni, P. Yiannacopulu, G. Canè, A. Bonfiglioli, R. Zandomeneghi, L. Brugioni, A. Giannini, R. Di Ruvo, M. Giuliani, L. Rusconi, P. Del Corso, G. Piovaccari, F. Bologna, P. Venturi, F. Melandri, E. Bagni, L. Bolognese, R. Perticucci, A. Zuppiroli, M. Nannini, N. Consoli, P. Petrone, C. Pipitò, L. Colombi, D. Bernardi, P.R. Mariani, R. Testa, F. Mazzinghi, F. Cosmi, D. Cosmi, A. Zipoli, A. Cecchi, G. Castelli, M. Ciaccheri, F. Mori, F. Pieri, P. Valoti, D. Chiarantini, G.M. Santoro, C. Minneci, F. Marchi, M. Milli, G. Zambaldi, A.A. Brandinelli Geri, M. Cipriani, M. Alessandri, S. Severi, S. Stefanelli, A. Comella, R. Poddighe, A. Digiorgio, M. Carluccio, S. Berti, A. Rizza, V. Bonatti, V. Molendi, A. Brancato, N. D'Aprile, G. Giappichini, S. Del Vecchio, G. Mantini, F. De Tommasi, G. Meucci, M. Cordoni, S. Bechi, L. Barsotti, P. Baldini, M. Romei, G. Scopelliti, G. Lauri, F. Pestelli, F. Furiozzi, M. Cocchieri, D. Severini, F. Patriarchi, P. Chiocchi, M. Buccolieri, S. Martinelli, A. Wee, F. Angelici, M. Bernardinangeli, G. Proietti, B. Biscottini, R. Panciarola, L. Marinacci, G.P. Perna, D. Gabrielli, A. Moraca, L. Moretti, L. Partemi, G. Gregori, R. Amici, G. Patteri, P. Capone, E. Savini, G.L. Morgagni, L. Paccaloni, F. Pezzuoli, S. Carincola, S. Papi, S. De Crescentini, P. Gerardi, P. Midi, E. Gallenzi, G. Pajes, C. Mancone, V. Di Spirito, M. Di Gennaro, S. Calcagno, S. Toscano, S. Antonicoli, F. Carta, G. Giorgi, F. Comito, E. Daniele, O. Ciarla, P.G. Gelfo, A. Acquaviva, D. Testa, G. Testa, F.A. Pagliaro, F. Russo, F. Vetta, I. Marchese, G. Di Sciascio, A. D'Ambrosio, F. Leggio, D. Del Sindaco, A. Lacchè, A. Avallone, M.P. Risa, P. Azzolini, E. Baldo, E. Giovannini, G. Pulignano, C. Tondo, E. Picchio, E. ani, P. Tanzi, F. Pozzar, F. Farnetti, M. Azzarito, M. Santini, A. Varveri, G. Ferraiuolo, C. Valtorta, A. Gaspardone, G. Barbato, V. Ceci, N. Aspromonte, F. Bellocci, C. Colizzi, F. Fedele, F.I. Perez, A. Galati, A. Rossetti, A. Mainella, D. etta, C. Matteucci, G. Busi, A. De Angelis, G. Farina, A. Granatelli, F. Leone, F. Frasca, R. Di Giovambattista, G. Castellani, G. Massaro, G. Mastrogiuseppe, A. Vacri, F. De Sanctis, M. Cioli, S. Di Luzio, C. Napoletano, L.L. Piccioni, G. De Simone, A. Ottaviano, V. Mazza, C. Spedaliere, D. Staniscia, E. Calgione, G. De Marco, T. Chiacchio, T. Di Napoli, S. Romanzi, G. Salvatore, P. Golino, A. Palermo, F. Mascia, A. Vetrano, A. Vinciguerra, L. Caliendo, R. Longobardi, G. De Caro, R. Di Nola, F. Piemonte, D. Prinzi, P. De Rosa, V. De Rosa, F. Riello, V. Capuano, G. Vecchio, M. Landi, S. Amato, M. Garofalo, M. D'Avino, P. Sensale, O. Maiolica, R. Santoro, P. Caso, D. Miceli, N. Maurea, U. Bianchi, C. Crispo, M. Chiariello, P. Perrone Filardi, L. Russo, N. Capuano, G. Ungaro, G. Vergara, F. Scafuro, G. D'Angelo, C. Campaniello, P. Bottiglieri, A. Volpe, R. Battista, L. De Risi, G. Cardillo, G. Sibilio, A.P. Marino, F. Silvestri, P. Predotti, A. Iervoglini, C. De Matteis, P. Sarnicola, M.M. Matarazzo, S. Baldi, V. Iuliano, C. Astarita, P. Cuccaro, A. Liguori, G. Liguori, G. Gregorio, L. Petraglia, G. Antonelli, G. Amodio, I. De Luca, D. Traversa, G. Franchini, M.L. Lenti, D. Cavallari, C. D'Agostino, G. Scalera, C.M. Altamura, M. Russo, A.R. Mascolo, G. Pettinati, S.A. Ciricugno, D. Scrutinio, A. Passantino, D. Mastrangelo, A. Di Masi, R. De Carne, M. Cannone, F. Dibiase, M. Pensato, F. Loliva, F. Trapani, I. Panettieri, L. Leone, M. Di Biase, M. Carrone, V. Gallone, F. Cocco, M. Costantini, C. Tritto, F. Cavalieri, L. Stella, F. Magliari, M. Callerame, A. De Giorgi, L. Pellegrino, M. Correra, V. Portulano, G.L. Nisi, G. Grassi, E. Cristallo, D. De Laura, C. Salerno, R. Fanelli, M. Villella, S. Pede, A. Renna, E. De Lorenzi, L. Urso, V. Lenti, A. Peluso, N. Baldi, G. Polimeni, P. Palma, R. Lauletta, E. Tagliamonte, T. Cirillo, B. Silvestri, G. Centonze, B. D'Alessandro, L. Truncellito, D. Mecca, M.A. Petruzzi, R.O.M. Coviello, A. Lopizzo, M. telli, S. Barbuzzi, S. Gubelli, G. Germinario, N. Cosentino, A. Mingrone, R. Vico, G. Borrello, M.L. Mazza, R. Cimino, D. Galasso, F. Cassadonte, U. Talarico, F. Perticone, S. Cassano, F. Catapano, S. Calemme, E. Feraco, C. Cloro, G. Misuraca, R. Caporale, L. Vigna, V. Spagnuolo, F. De Rosa, G. Spadafora, G. Zampaglione, R. Russo, F.A. Schipani, A.F. Ferragina, D. Stranieri, G. Musca, C. Carpino, P. Bencardino, F. Raimondo, D. Musacchio, G. Pulitanò, A. Ruggeri, A. Provenzano, S. Salituri, M. Musolino, S. Calandruccio, A. Marrari, E. Tripodi, R. Scali, L. Anastasio, A. Arone, P. Aragona, L. Donnangelo, M.G.A. Comito, F. Bilotta, I. Vaccaro, R. Rametta, V. Ventura, A. Bonvegna, A. Alì, C. Cinnirella, M. Raineri, F. Pompeo, N. Cascio Ingurgio, V. Carini, R. Coco, G. Giunta, G. Leonardi, V. Randazzo, V. Di Blasi, C. Tamburino, G. Russo, S. Mangiameli, R. Cardillo, D. Castelli, V. Inserra, A. Arena, M.M. Gulizia, S. Raciti, G. Rapisarda, R. Romano, P. Prestifilippo, G.B. Braschi, G. Ledda, R. Terrazzino, M. De Caro, G. Scilabra, B. agnino, R. Grassi, G. Di Tano, G.F. Scimone, L. Vasquez, C. Coppolino, A. Casale, M. Castelli, G. D'Urso, E. D'Antonio, L. Lo Presti, E. Badalamenti, P. Conti, N. Sanfilippo, V. Cirrincione, M.T. Cinà, G. Cusimano, A. Taormina, P. Giuliano, A. Bajardi, V. Mandalà, A. Canonico, G. Geraci, F.P. Sabella, F. Enia, A.M. Floresta, I. Lo Cascio, D. Gumina, A. Cavallaro, G. Piccione, R. Ferrante, M. Blandino, M.S. Iudicello, E. Mossuti, G. Romano, L. Lombardo, P. Monastra, D. Di Vincenzo, M. Porcu, P. Orrù, F. Muscas, G. Giardina, M. Corda, G. Locci, A. Podda, M. Ledda, P. Siddi, C. Lai, G. Pili, G. Mercuro, G. Mureddu, A. Ganau, G. Meloni, G. Poddighe, G. Sanna, Dauriz, Marco, Targher, Giovanni, Temporelli, Pier Luigi, Lucci, Donata, Gonzini, Lucio, Nicolosi, Gian Luigi, Marchioli, Roberto, Tognoni, Gianni, Latini, Roberto, Cosmi, Franco, Tavazzi, Luigi, Maggioni, Aldo Pietro, on behalf of the GISSI-HF, Investigator, Margonato, Alberto, Moccetti, T., Rossi, M. G., Pasotti, E., Vaghi, F., Roncarolo, P., Zunino, M. T., Matta, F., Actis Perinetto, E., Gaita, F., Azzaro, G., Zanetta, M., Paino, A. M., Parravicini, U., Vegis, D., Conte, R., Ferraro, P., De Bernardi, A., Morelloni, S., Fagnani, M., Greco Lucchina, P., Montagna, L., Bellone, E., Sappè, D., Ferraro, F., Delucchi, M., Reynaud, S. G., Dore, M., La Brocca, A., Massobrio, N., Bo, L., Trinchero, R., Imazio, M., Brocchi, G., Nejrotti, A., Rissone, L., Gabasio, S., Zocchi, C., Randazzo, S., Crenna, A., Giannuzzi, P., Bonanomi, E., Mezzani, A., De Marchi, M., Begliuomini, G., Gianonatti, C. A., Gavazzi, A., Grosu, A., Dei Cas, L., Nodari, S., Garyfallidis, P., Bertoletti, A., Bonifazi, C., Arisi, S., Mascaro, F., Fraccarollo, M., Dell'Orto, S., Sfolcini, M., Bortolini, F., Raccagni, D., Turelli, A., Santarone, M., Miglierina, E., Sormani, L., Jemoli, R., Tettamanti, F., Pirelli, S., Bianchi, C., Verde, S., Mariani, M., Ziacchi, V., Ferrazza, A., Russo, A., Bortolotti, M., Pasini, G. F., Volpi, A., Jones, K. N., Cuzzucrea, D., Gullace, G., Carbone, C., Granata, A., De Servi, S., Del Rosso, G., Inserra, C., Renaldini, E., Zappa, C., Moretti, M., Zanini, R., Ferrari, M., Moroni, E., Cei, A., Lissi, C., Dovico, E., Fiorentini, C., Palermo, P., Brusoni, B., Negrini, M., Heyman, J., Danzi, G. B., Finzi, A., Frigerio, M., Turazza, F., Beretta, L., Sachero, A., Casazza, F., Squadroni, L., Lombardi, F., Marano, L., Margonato, A., Fragasso, G., Febo, O. C., Aiolfi, E., Olmetti, F., Grieco, A., Antonazzo, V., Specchia, G., Mortara, A., Robustelli, F., Songini, M. G., Schweiger, C., Frisinghelli, A., Palvarini, M., Campana, C., Scelsi, L., Ajmone Marsan, N., Cobelli, F., Gualco, A., Opasich, C., De Feo, S., Mazzucco, R., Iannone, M. A., Diaco, T., Zaniboni, D., Milanesi, G., Nassiacos, D., Meloni, S., Giani, P., Nicoli, T., Malinverni, C., Gusmini, A., Pozzoni, L., Bisiani, G., Margaroli, P., Schizzarotto, A., Daverio, A., Occhi, G., Partesana, N., Bandini, P., Rosella, M. G., Giustiniani, S., Cucchi, G., Pedretti, R., Raimondo, R., Vaninetti, R., Fedele, A., Ghezzi, I., Rezzonico, E., Salerno Uriarte, J. A., Morandi, F., Salvucci, F., Valenti, C., Graziano, G., Romanò, M., Cimminiello, C., Mangone, I., Lombardo, M., Quorso, P., Marinoni, G., Breghi, M., Erckert, M., Dienstl, A., Mirante Marini, G., Stefenelli, C., Cioffi, G., Buczkowska, E., Bonanome, A., Bazzanini, F., Parissenti, L., Serafini, C., Catania, G., Tarantini, L., Rigatelli, G., Boni, S., Pasini, A., Masini, E., Zampiero, A. A., Zanchetta, M., Franceschetto, L., Delise, P., Marcon, C., Sacchetta, A., Borgese, L., Artusi, L., Casolino, P., Corbara, F., Banzato, A., Barbiero, M., Aldegheri, M. P., Bazzucco, R., Crivellenti, G., Raviele, A., Zanella, C., Pascotto, P., Sarto, P., Milan, S., Barbieri, E., Girardi, P., Dalla Villa, W., Dalle Mule, J., Di Sipio, M. L., Cazzin, R., Milan, D., Zonzin, P., Carraro, M., Rossi, R., Carbonieri, E., Rossi, I., Stritoni, P., Meneghetti, P., Risica, G., Tenderini, P. L., Vassanelli, C., Zanolla, L., Perini, G., Brighetti, G., Chiozza, R., Giuliano, G., Baldin, M. G., Gortan, R., Cesanelli, R., Nicolosi, G. L., Piazza, R., Mos, L., Vriz, O., Pavan, D., Pascottini, G., Alberti, E., Werren, M., Solinas, L., Sinagra, G., Longaro, F., Fioretti, P., Albanese, M. C., Miani, D., Gianrossi, R., Pende, A., Rubartelli, P., Magaia, O., Domenicucci, S., Caruso, D., Faraguti, A. S., Magliani, L., Miccoli, F., Guglielmino, G., Bertoli, D., Cantarelli, A., Orlandi, S., Vallebona, A., Pozzati, A., Brega, G., Pancaldi, L. G., Vandelli, R., Urbinati, S., Poci, M. G., Zoli, M., Costa, G. M., Guiducci, U., Zobbi, G., Tartagni, F., Tisselli, A., Gentili, A., Pieri, P., Cagnetta, E., Bendinelli, S., Barbieri, A., Conti, R., Ferrari, R., Merlini, F., Fucili, A., Moruzzi, P., Buia, E., Galvani, M., Ferrini, D., Baggioni, G., Yiannacopulu, P., Canè, G., Bonfiglioli, A., Zandomeneghi, R., Brugioni, L., Giannini, A., Di Ruvo, R., Giuliani, M., Rusconi, L., Del Corso, P., Piovaccari, G., Bologna, F., Venturi, P., Melandri, F., Bagni, E., Bolognese, L., Perticucci, R., Zuppiroli, A., Nannini, M., Consoli, N., Petrone, P., Pipitò, C., Colombi, L., Bernardi, D., Mariani, P. R., Testa, R., Mazzinghi, F., Cosmi, F., Cosmi, D., Zipoli, A., Cecchi, A., Castelli, G., Ciaccheri, M., Mori, F., Pieri, F., Valoti, P., Chiarantini, D., Santoro, G. M., Minneci, C., Marchi, F., Milli, M., Zambaldi, G., Brandinelli Geri, A. A., Cipriani, M., Alessandri, M., Severi, S., Stefanelli, S., Comella, A., Poddighe, R., Digiorgio, A., Carluccio, M., Berti, S., Rizza, A., Bonatti, V., Molendi, V., Brancato, A., D'Aprile, N., Giappichini, G., Del Vecchio, S., Mantini, G., De Tommasi, F., Meucci, G., Cordoni, M., Bechi, S., Barsotti, L., Baldini, P., Romei, M., Scopelliti, G., Lauri, G., Pestelli, F., Furiozzi, F., Cocchieri, M., Severini, D., Patriarchi, F., Chiocchi, P., Buccolieri, M., Martinelli, S., Wee, A., Angelici, F., Bernardinangeli, M., Proietti, G., Biscottini, B., Panciarola, R., Marinacci, L., Perna, G. P., Gabrielli, D., Moraca, A., Moretti, L., Partemi, L., Gregori, G., Amici, R., Patteri, G., Capone, P., Savini, E., Morgagni, G. L., Paccaloni, L., Pezzuoli, F., Carincola, S., Papi, S., De Crescentini, S., Gerardi, P., Midi, P., Gallenzi, E., Pajes, G., Mancone, C., Di Spirito, V., Di Gennaro, M., Calcagno, S., Toscano, S., Antonicoli, S., Carta, F., Giorgi, G., Comito, F., Daniele, E., Ciarla, O., Gelfo, P. G., Acquaviva, A., Testa, D., Testa, G., Pagliaro, F. A., Russo, F., Vetta, F., Marchese, I., Di Sciascio, G., D'Ambrosio, A., Leggio, F., Del Sindaco, D., Lacchè, A., Avallone, A., Risa, M. P., Azzolini, P., Baldo, E., Giovannini, E., Pulignano, G., Tondo, C., Picchio, E., Biffani, E., Tanzi, P., Pozzar, F., Farnetti, F., Azzarito, M., Santini, M., Varveri, A., Ferraiuolo, G., Valtorta, C., Gaspardone, A., Barbato, G., Ceci, V., Aspromonte, N., Bellocci, F., Colizzi, C., Fedele, F., Perez, F. I., Galati, A., Rossetti, A., Mainella, A., Ciuffetta, D., Matteucci, C., Busi, G., De Angelis, A., Farina, G., Granatelli, A., Leone, F., Frasca, F., Di Giovambattista, R., Castellani, G., Massaro, G., Mastrogiuseppe, G., Vacri, A., De Sanctis, F., Cioli, M., Di Luzio, S., Napoletano, C., Piccioni, L. L., De Simone, G., Ottaviano, A., Mazza, V., Spedaliere, C., Staniscia, D., Calgione, E., De Marco, G., Chiacchio, T., Di Napoli, T., Romanzi, S., Salvatore, G., Golino, P., Palermo, A., Mascia, F., Vetrano, A., Vinciguerra, A., Caliendo, L., Longobardi, R., De Caro, G., Di Nola, R., Piemonte, F., Prinzi, D., De Rosa, P., De Rosa, V., Riello, F., Capuano, V., Vecchio, G., Landi, M., Amato, S., Garofalo, M., D'Avino, M., Sensale, P., Maiolica, O., Santoro, R., Caso, P., Miceli, D., Maurea, N., Bianchi, U., Crispo, C., Chiariello, M., Perrone Filardi, P., Russo, L., Capuano, N., Ungaro, G., Vergara, G., Scafuro, F., D'Angelo, G., Campaniello, C., Bottiglieri, P., Volpe, A., Battista, R., De Risi, L., Cardillo, G., Sibilio, G., Marino, A. P., Silvestri, F., Predotti, P., Iervoglini, A., De Matteis, C., Sarnicola, P., Matarazzo, M. M., Baldi, S., Iuliano, V., Astarita, C., Cuccaro, P., Liguori, A., Liguori, G., Gregorio, G., Petraglia, L., Antonelli, G., Amodio, G., De Luca, I., Traversa, D., Franchini, G., Lenti, M. L., Cavallari, D., D'Agostino, C., Scalera, G., Altamura, C. M., Russo, M., Mascolo, A. R., Pettinati, G., Ciricugno, S. A., Scrutinio, D., Passantino, A., Mastrangelo, D., Di Masi, A., De Carne, R., Cannone, M., Dibiase, F., Pensato, M., Loliva, F., Trapani, F., Panettieri, I., Leone, L., Di Biase, M., Carrone, M., Gallone, V., Cocco, F., Costantini, M., Tritto, C., Cavalieri, F., Stella, L., Magliari, F., Callerame, M., De Giorgi, A., Pellegrino, L., Correra, M., Portulano, V., Nisi, G. L., Grassi, G., Cristallo, E., De Laura, D., Salerno, C., Fanelli, R., Villella, M., Pede, S., Renna, A., De Lorenzi, E., Urso, L., Lenti, V., Peluso, A., Baldi, N., Polimeni, G., Palma, P., Lauletta, R., Tagliamonte, E., Cirillo, T., Silvestri, B., Centonze, G., D'Alessandro, B., Truncellito, L., Mecca, D., Petruzzi, M. A., Coviello, R. O. M., Lopizzo, A., Chiaffitelli, M., Barbuzzi, S., Gubelli, S., Germinario, G., Cosentino, N., Mingrone, A., Vico, R., Borrello, G., Mazza, M. L., Cimino, R., Galasso, D., Cassadonte, F., Talarico, U., Perticone, F., Cassano, S., Catapano, F., Calemme, S., Feraco, E., Cloro, C., Misuraca, G., Caporale, R., Vigna, L., Spagnuolo, V., De Rosa, F., Spadafora, G., Zampaglione, G., Russo, R., Schipani, F. A., Ferragina, A. F., Stranieri, D., Musca, G., Carpino, C., Bencardino, P., Raimondo, F., Musacchio, D., Pulitanò, G., Ruggeri, A., Provenzano, A., Salituri, S., Musolino, M., Calandruccio, S., Marrari, A., Tripodi, E., Scali, R., Anastasio, L., Arone, A., Aragona, P., Donnangelo, L., Comito, M. G. A., Bilotta, F., Vaccaro, I., Rametta, R., Ventura, V., Bonvegna, A., Alì, A., Cinnirella, C., Raineri, M., Pompeo, F., Cascio Ingurgio, N., Carini, V., Coco, R., Giunta, G., Leonardi, G., Randazzo, V., Di Blasi, V., Tamburino, C., Russo, G., Mangiameli, S., Cardillo, R., Castelli, D., Inserra, V., Arena, A., Gulizia, M. M., Raciti, S., Rapisarda, G., Romano, R., Prestifilippo, P., Braschi, G. B., Ledda, G., Terrazzino, R., De Caro, M., Scilabra, G., Graffagnino, B., Grassi, R., Di Tano, G., Scimone, G. F., Vasquez, L., Coppolino, C., Casale, A., Castelli, M., D'Urso, G., D'Antonio, E., Lo Presti, L., Badalamenti, E., Conti, P., Sanfilippo, N., Cirrincione, V., Cinà, M. T., Cusimano, G., Taormina, A., Giuliano, P., Bajardi, A., Mandalà, V., Canonico, A., Geraci, G., Sabella, F. P., Enia, F., Floresta, A. M., Lo Cascio, I., Gumina, D., Cavallaro, A., Piccione, G., Ferrante, R., Blandino, M., Iudicello, M. S., Mossuti, E., Romano, G., Lombardo, L., Monastra, P., Di Vincenzo, D., Porcu, M., Orrù, P., Muscas, F., Giardina, G., Corda, M., Locci, G., Podda, A., Ledda, M., Siddi, P., Lai, C., Pili, G., Mercuro, G., Mureddu, G., Ganau, A., Meloni, G., Poddighe, G., Sanna, G., Barlera, Simona, Franzosi, Maria Grazia, Porcu, Maurizio, Yusuf, Salim, Camerini, Fulvio, Cohn, Jay N., Decarli, Adriano, Pitt, Bertram, Sleight, Peter, Poole-Wilson, Philip A., Geraci, Enrico, Scherillo, Marino, Fabbri, Gianna, Bartolomei, Barbara, Bertoli, Daniele, Cobelli, Franco, Fresco, Claudio, Ledda, Antonietta, Levantesi, Giacomo, Opasich, Cristina, Rusconi, Franco, Sinagra, Gianfranco, Turazza, Fabio, Volpi, Alberto, Ceseri, Martina, Alongi, Gianluca, Atzori, Antonio, Bambi, Filippo, Bastarolo, Desiree, Bianchini, Francesca, Cangioli, Iacopo, Canu, Vittoriana, Caporusso, Concetta, Cenni, Gabriele, Cintelli, Laura, Cocchio, Michele, Confente, Alessia, Fenicia, Eva, Friso, Giorgio, Gianfriddo, Marco, Grilli, Gianluca, Lazzaro, Beatrice, Lonardo, Giuseppe, Luise, Alessia, Nota, Rachele, Orlando, Mariaelena, Petrolo, Rosaria, Pierattini, Chiara, Pierota, Valeria, Provenzani, Alessandro, Quartuccio, Velia, Ragno, Anna, Serio, Chiara, Spolaor, Alvise, Tafi, Arianna, Tellaroli, Elisa, Ghio, Stefano, Ghizzardi, Elisa, Masson, Serge, Crociati, Lella, La Rovere, Maria Teresa, Corrà, Ugo, Di Giulio, Paola, Finzi, Andrea, Gorini, Marco, Milani, Valentina, Orsini, Giampietro, Bianchini, Elisa, Cabiddu, Silvia, Cangioli, Ilaria, Cipressa, Laura, Cipressa, Maria Lucia, Di Bitetto, Giuseppina, Ferri, Barbara, Galbiati, Luisa, Lorimer, Andrea, Pera, Carla, Priami, Paola, and Vasamì, Antonella

Subjects
Blood Glucose, Male, Glycated Hemoglobin A, heart failure, Kaplan-Meier Estimate, prediabetes, 030204 cardiovascular system & hematology, time factors, Settore MED/11, cause of death, 0302 clinical medicine, Glycemic control, prediabetic state, Cause of Death, italy, middle aged, Prevalence, 80 and over, double-blind method, blood glucose, risk factors, 030212 general & internal medicine, Prediabetes, Rosuvastatin Calcium, humans, rosuvastatin calcium, Cause of death, Original Research, Metabolic Syndrome, Aged, 80 and over, adult, Chronic heart failure, Diabetes mellitus, Heart failure, Mortality, Cardiology and Cardiovascular Medicine, Hazard ratio, chronic heart failure, diabetes mellitus, glycemic control, mortality, Treatment Outcome, Adolescent, Biomarkers, Chronic Disease, Diabetes Mellitus, Fatty Acids, Omega-3, Double-Blind Method, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Hospitalization, Heart Failure, Italy, Prediabetic State, Risk Assessment, Proportional Hazards Models, Risk Factors, Time Factors, risk assessment, Middle Aged, kaplan-meier estimate, aged, female, Prediabete, young adult, Female, omega-3, Human, hospitalization, Adult, medicine.medical_specialty, Diabetes mellitu, proportional hazards models, Time Factor, hydroxymethylglutaryl-coa reductase inhibitors, prevalence, fatty acids, 03 medical and health sciences, Young Adult, male, Internal medicine, Post-hoc analysis, glycated hemoglobin a, medicine, Intensive care medicine, Aged, Glycated Hemoglobin, Proportional hazards model, business.industry, Risk Factor, biomarkers, Biomarker, medicine.disease, Clinical trial, adolescent, Proportional Hazards Model, treatment outcome, aged, 80 and over, chronic disease, fatty acids, omega-3, cardiology and cardiovascular medicine, Hydroxymethylglutaryl-CoA Reductase Inhibitor, business
Abstract

Background The independent prognostic impact of diabetes mellitus ( DM ) and prediabetes mellitus (pre‐ DM ) on survival outcomes in patients with chronic heart failure has been investigated in observational registries and randomized, clinical trials, but the results have been often inconclusive or conflicting. We examined the independent prognostic impact of DM and pre‐ DM on survival outcomes in the GISSI ‐HF (Gruppo Italiano per lo Studio della Sopravvivenza nella Insufficienza Cardiaca‐Heart Failure) trial. Methods and Results We assessed the risk of all‐cause death and the composite of all‐cause death or cardiovascular hospitalization over a median follow‐up period of 3.9 years among the 6935 chronic heart failure participants of the GISSI ‐ HF trial, who were stratified by presence of DM (n=2852), pre‐ DM (n=2013), and non‐ DM (n=2070) at baseline. Compared with non‐ DM patients, those with DM had remarkably higher incidence rates of all‐cause death (34.5% versus 24.6%) and the composite end point (63.6% versus 54.7%). Conversely, both event rates were similar between non‐ DM patients and those with pre‐ DM . Cox regression analysis showed that DM , but not pre‐ DM , was associated with an increased risk of all‐cause death (adjusted hazard ratio, 1.43; 95% CI , 1.28–1.60) and of the composite end point (adjusted hazard ratio, 1.23; 95% CI , 1.13–1.32), independently of established risk factors. In the DM subgroup, higher hemoglobin A1c was also independently associated with increased risk of both study outcomes (all‐cause death: adjusted hazard ratio, 1.21; 95% CI , 1.02–1.43; and composite end point: adjusted hazard ratio, 1.14; 95% CI , 1.01–1.29, respectively). Conclusions Presence of DM was independently associated with poor long‐term survival outcomes in patients with chronic heart failure. Clinical Trial Registration URL : http://www.clinicaltrials.gov . Unique identifier: NCT 00336336.

Published
2017
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10. Iodine compounds speciation in HI–I 2 aqueous solutions by Raman spectroscopy

Author

Raffaele Liberatore, Michele Marrocco, G. Salvatore Sau, Annarita Spadoni, Pietro Tarquini, Michela Lanchi, and Mauro Falconieri

Subjects
Aqueous solution, Hydrogen, Renewable Energy, Sustainability and the Environment, Inorganic chemistry, Analytical chemistry, Energy Engineering and Power Technology, chemistry.chemical_element, Electrolyte, Condensed Matter Physics, Decomposition, symbols.namesake, Fuel Technology, chemistry, Bunsen reaction, symbols, Thermochemical cycle, Raman spectroscopy, Hydrogen production
Abstract

The Sulphur–Iodine (S–I) thermochemical cycle for hydrogen production from water is one of the widest investigated cycles in the world. The S–I cycle is composed of three main sections which correspond to its three main reactions: the Bunsen reaction, the hydriodic acid (HI) decomposition and the sulphuric acid decomposition. The investigation, comprehension and modelling of the complex electrolytic chemistry of the HI solutions is crucial for the process optimization. In particular, the analysis of chemical speciation in the HI solutions is a key factor for the full understanding of the chemical equilibria involved at varying I 2 :HI ratio in the mixtures. The aim of the present study is to use Raman spectroscopy for characterizing the chemical speciation of iodine compounds existing in the mixtures that pertain to the S–I process. For this purpose, Raman spectra of solutions with known HI and I 2 concentration have been recorded. It has been found that the chemistry of these solutions is highly dependent on I 2 :HI molar ratio. Up to 1:1 ratio, I 3 − and its corresponding ion pair HI 3 * are the dominant iodine compounds. At higher values, the formation of higher polyiodine and polyiodides compounds has been suggested.

Published
2012
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13. Occult stress urinary incontinence in women with pelvic organ prolapse: Is the one step surgical approach a risky choice?

Author

Zacharakis, D. Grigoriadis, T. Kastanias, S. Giannoulis, G. Salvatore, S. Athanasiou, S.

Abstract

Objectives Occult stress urinary incontinence (SUI, OSUI) is defined as the demonstration of SUI after pelvic organ prolapse (POP) reduction. The aim of this study was to evaluate the effectiveness and complication rates of the 1-step surgical approach for treating women with POP and OSUI. Methods Retrospective study of women with POP and OSUI who underwent a concomitant prolapse and midurethral sling procedure was conducted. Main outcome measures were absence of postoperative urodynamic stress incontinence (USI) and absence of postoperative SUI at 12 months. Secondary outcome measures included evaluation of objective and subjective parameters related to the lower urinary tract function and assessment of the quality of life. Results Of the 244 women, 205 women (84%) attended the 12-month postoperative follow-up visit and were included in the study. Overall, 87.8% (180/205) of the patients had absence of postoperative urodynamic stress incontinence, whereas 95.1% (195/205) did not report postoperative SUI. Evaluation of parameters related to the postoperative lower urinary tract dysfunction showed that (a) 43% of women with preexisting urgency symptoms continued to have urgency, (b) 16.7% of patients presented de novo urgency, (c) de novo detrusor overactivity occurred in 9.3% of patients, and (d) 4.9% of women with preoperative obstructive voiding symptoms continued to have obstructive voiding symptoms after combined surgery. King's Health Questionnaire data analysis showed a statistically significant improvement in all domains. Conclusions This 1-step approach is both safe and effective and could be offered as a valid operative choice for those women who wish or should avoid a repeat surgical procedure for postoperative SUI. © 2015 Wolters Kluwer Health, Inc.

Published
2016

14. Chromatin assembly factor-1 (CAF-1)-mediated regulation of cell proliferation and DNA repair: a link with the biological behaviour of squamous cell carcinoma of the tongue?

Author

G Salvatore, C Mignogna, Lorenzo Lo Muzio, M Mascolo, L Califano, Corrado Rubini, M Di Benedetto, S Staibano, G De Rosa, Staibano, Stefania, Mignogna, C, LO MUZIO, L, Mascolo, Massimo, Salvatore, G, DI BENEDETTO, M, Califano, Luigi, Rubini, C, and DE ROSA, Gaetano

Subjects
Male, Pathology, medicine.medical_specialty, Histology, DNA Repair, DNA repair, Blotting, Western, Down-Regulation, Biology, Pathology and Forensic Medicine, Immunoenzyme Techniques, Proliferating Cell Nuclear Antigen, Biomarkers, Tumor, medicine, Humans, Proliferation Marker, Chromatin Assembly Factor-1, Aged, Cell Proliferation, Aged, 80 and over, Cell growth, DNA, Neoplasm, General Medicine, Middle Aged, Cell cycle, Tongue Neoplasms, Chromatin, Proliferating cell nuclear antigen, Survival Rate, Epidermoid carcinoma, Fluorescent Antibody Technique, Direct, Carcinoma, Squamous Cell, Cancer research, biology.protein, Female, Transcription Factors
Abstract

Aims: Squamous cell carcinoma (SCC) of the tongue shows aggressive behaviour and a poor prognosis. Clinicopathological parameters fail to provide reliable prognostic information, so the search continues for new molecular markers for this tumour. Chromatin assembly factor-1 (CAF-1) plays a major role in chromatin assembly during cell replication and DNA repair and has been proposed as a new proliferation marker. The aim of this study was to investigate its expression in SCC of the tongue. Methods and results: The immunohistochemical expression of the p60 and p150 subunits of CAF-1 were evaluated in a series of SCCs of the tongue. The findings were correlated with the expression of proliferation cell nuclear antigen (PCNA) and patients' clinicopathological and follow-up data. CAF-1/p60 was expressed in all the tumours, whereas CAF-1/p150 was down-regulated in a number of cases. Overexpression of CAF-1/p60 and down-regulation of CAF-1/p150 identified SCCs with poor outcome, in addition to the classical prognostic parameters. Conclusions: Simultaneous CAF-1-mediated deregulation of cell proliferation and DNA repair takes place in aggressive SCC of the tongue. Therefore, the evaluation of CAF-1 expression may be a valuable tool for evaluation of the biological behaviour of these tumours. This may be relevant to the introduction of improved follow-up protocols and/or alternative therapeutic regimens.

Published
2007
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15. Acaricidal properties of the essential oil of Melaleuca alternifolia Cheel (tea tree oil) against nymphs of Ixodes ricinus

Author

D Grazioli, E Gentile, A. Iori, G Salvatore, and G Marano

Subjects
Nymph, Insecticides, Veterinary medicine, Time Factors, Ixodes ricinus, Melaleuca, law.invention, Random Allocation, Tea Tree Oil, law, Botany, medicine, Animals, Essential oil, Random allocation, Dose-Response Relationship, Drug, Ixodes, Tick Control, General Veterinary, biology, Tea tree oil, Melaleuca alternifolia, General Medicine, biology.organism_classification, humanities, Arachnid Vectors, Parasitology, medicine.drug
Abstract

The aim of the study was to examine the acaricidal effect of essential oil of Melaleuca alternifolia (tea tree oil, TTO) at different doses (4, 6, 8 and 10 microl) and for different exposure times (30, 60, 90 and 120 min) on nymphs of Ixodes ricinus. A dose of 8 microl TTO was lethal for more than 70% of ticks when inhaled and this effect was enhanced when the dose was increased to 10 microl (> 80%). The effect was correlated with the duration of exposure of ticks to TTO, with a significant effect being observed after 90 min exposure. The findings show that TTO has acaricidal properties and could be extremely useful in controlling ticks that are efficient vectors of pathogens.

Published
2005
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16. Psychological Aspects in Parents of Children with Disability and Behavior Problems

Author

C. Levi, A. antonella, G. Salvatore, E. Nardecchia, P. Andrea, and F. Ricci

Subjects
Rehabilitation, media_common.quotation_subject, medicine.medical_treatment, CBCL, Developmental psychology, Psychiatry and Mental health, Increased risk, Developmental stage theories, medicine, Family resilience, Psychological aspects, Psychology, Welfare, Depression (differential diagnoses), Clinical psychology, media_common
Abstract

IntroductionParents of children with disabilities are at increased risk of experiencing psychological stress compared to other parents. Children's high levels of internalizing and externalizing problems have been found to contribute to this elevated level of stress. Childhood disability often imposes a social and emotional burden for children and their families.ObjectiveWith this study we evaluated several parents’ psychological aspects and the emotional behavioral functioning of their children with disability.AimTo investigate the possible correlation between parenting stress, level of depression in parents and behavior problems in their children, taking in to account the differences between mothers and fathers.Methodstandardized forms (CBCL, PSI, BDI) were completed from 57 (28 mothers) parents of children aged from 6 to18 years, focusing on psychological well-being includes depression, parenting stress, family resilience and family adjustment.ResultsThe mean age of our sample was 41.55 ± 5.4. The level of depression and stress index were higher in mothers than in fathers. Parenting stress was significantly associated with children internalizing and externalizing behavior problems in children.ConclusionThe results of this investigation indicate the importance of examining relations between parenting stress and behavior problems in children with disabilities. Objective of ensuring the rehabilitation process aimed at the welfare of the family. These patterns have implications for both developmental theory and for service provision for individuals with disability and their families.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Published
2017
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20. DETECTION OF BIOLOGICAL PROFILE OF CUTANEOUS MALIGNANT MELANOMA: A ROLE FOR CAF-1/P60 PROTEIN AND STEM-CELL MARKER CD133 EXPRESSION?

Author

STAIBANO, STEFANIA, MASCOLO, MASSIMO, M. Di Benedetto, ILARDI, GENNARO, M. L. Vecchione, G. Salvatore, L. Nugnes, DE ROSA, GAETANO, Stefania Staibano, Massimo Mascolo, Maria Di Benedetto, Gennaro Ilardi, Maria Luisa Vecchione, Gaetano Salvatore, Loredana Nugnes, and Gaetano De Rosa., Staibano, Stefania, Mascolo, Massimo, Di Benedetto, Maria, Ilardi, Gennaro, Vecchione, Maria Luisa, Salvatore, Gaetano, Nugnes, Loredana, DE ROSA, Gaetano, M., Di Benedetto, M. L., Vecchione, G., Salvatore, and L., Nugne

Abstract

Cutaneous melanoma (CM) is the most lethal skin malignancy, with a constant increase in incidence. These tumors show a biological behavior unpredictable by the classical parameters Moreover, conventional therapies are ineffective to treat advanced stage case. Therefore, the identification of molecular alterations involved in their biological aggressiveness represents a major challenge for researchers. Accumulating evidence supports the involvement of cancer stem cells (CSC) in initiation, progression, chemoresistance and therapeutic failure of malignant melanoma, and the aggressive subsets of melanoma cells have been frequently associated with molecular markers shared by stem cells.

Published
2008

21. CAF-1 p60 as a new marker of cell proliferation in plaque psoriasis

Author

STAIBANO, STEFANIA, MASCOLO, MASSIMO, DE ROSA, GAETANO, A. Longobardi, G. Salvatore, M. Di Benedetto, M. Nino, N. Balato, AYALA, FABIO, Staibano, Stefania, A., Longobardi, G., Salvatore, M., Di Benedetto, Mascolo, Massimo, M., Nino, N., Balato, DE ROSA, Gaetano, and Ayala, Fabio

Abstract

Previous studies of psoriatic epidermis showed that keratinocytes within psoriatic plaques have a resistance to apoptosis and are characterized by increased cell proliferation if compared with normal skin. The resistance to apoptosis has been particularly linked to the absence of a significant amount of double-stranded DNA breaks, in spite of the reported TUNEL (Terminal deoxynucleotidyl Transferase Biotin-dUTP Nick End Labeling) reactivity of most psoriatic lesions. This phenomenon has been interpreted as due to the increase in the number of DNA nicks resulting from active DNA replication, instead that DNA double-strands breaks resulting from the apoptotic process. CAF-1 p60 is a newly proposed proliferation marker, which plays a key role in chromatin assembly during cell replication and DNA repair. It is a part of a heterotrimeric complex (CAF-1) that regulates, in particular, DNA chromosome assembly during cell replication and the resulting chromatin structure after nucleotide excision repair (NER)-mediated DNA repair. CAF-1 has to interact with PCNA (Proliferating Cell Nuclear Antigen); p60, in particular, is down-regulated in quiescent cells, whereas it is over-expressed in hyperproliferating and neoplastic cells. We analyzed the immunohistochemical expression of p60 and PCNA in a series of plaque psoriasis samples (formalin-fixed, paraffin-embedded). A significant higher labelling of psoriatic keratinocytes for p60 than to PCNA was found. Our data suggest that the immunohistochemical p60 expression could represent a sensible instrument to evaluate the deregulation of cell proliferation in psoriasis, giving useful informations on both the cell-cycle progression and DNA-repair status of keratinocytes. In addition p60 expression could represent a valuable tool to evaluate the effect of therapy in follow-up of psoriatic patients.

Published
2007

22. Synthesis and potential coanthracyclinic activity of pyridylmethylene and indolylmethylene lactams

Author

Iraklis Galatulas, Fraccari A, Alberto Leoni, Rita Morigi, M Chiericozzi, G Salvatore, Alessandra Locatelli, and Aldo Andreani

Subjects
Pharmacology, chemistry.chemical_compound, 2-indolinone, chemistry, Established cell line, Stereochemistry, Organic Chemistry, Drug Discovery, Lactam, General Medicine, Chemical synthesis
Abstract

The synthesis of pyridylmethylene lactams and indolylmethylene-2-indolinones is reported. These compounds were tested for their cytotoxic and positive inotropic activity. The presence of both the effects (coanthracyclinic activity) was confirmed in some of the indolylmethylene-2-indolinones.

Published
1998
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23. Potential Antitumor Agents. 24. Synthesis and Pharmacological Behavior of Imidazo[2,1-b]thiazole Guanylhydrazones Bearing at Least One Chlorine

Author

Alberto Leoni, G Salvatore, Aldo Andreani, Rosaria Bossa, Mirella Rambaldi, Iraklis Galatulas, Alessandra Locatelli, and Fraccari A

Subjects
Cardiotonic Agents, Stereochemistry, Antineoplastic Agents, Chemical synthesis, HeLa, Mice, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Drug Discovery, Animals, Humans, Structure–activity relationship, Carcinoma, Ehrlich Tumor, Thiazole, Cytotoxicity, biology, Bicyclic molecule, Hydrazones, biology.organism_classification, Combinatorial chemistry, Thiazoles, chemistry, Molecular Medicine, Female, Chlorine, Drug Screening Assays, Antitumor, HeLa Cells
Abstract

In connection with a previous research dealing with the antitumor activity of imidazo[2,1-b]-thiazole guanylhydrazones, this paper reports the synthesis of new derivatives which were tested for antitumor and positive inotropic activity. In most cases the cytotoxic data from the in vitro experiments (HeLa) were in agreement with the antitumor data in vivo (Ehrlich). The active compounds bear a phenyl ring at the 6 position. On the other hand, the most active cardiotonic agents were devoid of the phenyl ring.

Published
1996
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24. Synthesis and cardiotonic activity of imidazo[2,l-b]thiazoles bearing a lactam ring

Author

Aldo Andreani, G Salvatore, M Chiericozzi, Mirella Rambaldi, Rosaria Bossa, Iraklis Galatulas, Alessandra Locatelli, and Alberto Leoni

Subjects
Pharmacology, Barbituric acid, Bicyclic molecule, Imidazothiazole, Stereochemistry, Organic Chemistry, Substituent, General Medicine, Ring (chemistry), Chemical synthesis, chemistry.chemical_compound, chemistry, Methine group, Drug Discovery, polycyclic compounds, Lactam
Abstract

Summary This paper describes the synthesis of 6-substituted imidazo[2,1- b ]thiazoles with a lactam ring connected, by means of a methine group, to the 5-position. The pharmacological results show that interesting cardiotonic activity is obtained when the lactam ring is pseudothiohydantoin ( 8 ) or barbituric acid ( 9 ). Even the substituent at position 6 plays an important role in the pharmacological behavior of these derivatives. The following activity rank order was observed: phenyl > methyl > chlorine.

Published
1996
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26. Molecular heterogeneity of covalently-linked bovine thyroglobulin dimers

Author

Gaetano Salvatore, Fabrizio Gentile, and G. Salvatore

Subjects
Chemistry, medicine.medical_treatment, medicine, Disulfide bond, General Earth and Planetary Sciences, Thyroglobulin, General Agricultural and Biological Sciences, Molecular heterogeneity, Molecular biology, General Environmental Science
Abstract

L’elettroforesi della tireoglobulina 19 S bovina in condizioni denaturanti, non riducenti ha rivelato, oltre ai monomeri di tireoglobulina 12 S, quattro specie distinte di dimeri covalenti. Dimeri diversi esposti all’azionedel 2-mer-captoetanolo hanno mostrato composizione in polipeptidi simile, ma diversa suscettibilita alla dissociazione per mezzo della riduzione dei ponti disolfuro intermonomerici. L’abbondanza di questi dimeri era correlata al contenuto in iodio della tireoglobulina. I vari tipi di dimeri covalenti della tireoglobulina differiscono, apparentemente, per il numero e la posizione dei ponti disolfuro intermonomerici.

Published
1995
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29. Synthesis and cardiotonic activity of aryl- or pyridyl-substituted fused imidazoles

Author

Alessandra Locatelli, Iraklis Galatulas, G Salvatore, Aldo Andreani, Mirella Rambaldi, and Rosaria Bossa

Subjects
Pharmacology, chemistry.chemical_compound, Benzothiazole, chemistry, Bicyclic molecule, Group (periodic table), Aryl, Organic Chemistry, Drug Discovery, Biological activity, General Medicine, Medicinal chemistry
Abstract

The syntheses of 4 different fused imidazoles bearing a 2,5-dimethoxyphenyl group or a pyridyl group are reported. All the heterocycles, except 2a , display positive inotropic activity. Some are approximately equipotent with sulmazole, and the imidazo[2,1- b ]benzothiazole that bears a 4-pyridyl group is the most active of whole series.

Published
1994
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30. Synthesis of lactams with potential cardiotonic activity

Author

Alessandra Locatelli, G Salvatore, M Chiericozzi, Aldo Andreani, Iraklis Galatulas, Alberto Leoni, Mirella Rambaldi, and Rosaria Bossa

Subjects
Pharmacology, 2-indolinone, chemistry.chemical_compound, Chemistry, Organic Chemistry, Drug Discovery, Lactam, Organic chemistry, Biological activity, General Medicine, Combinatorial chemistry
Published
1993
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32. ChemInform Abstract: Synthesis and Cardiotonic Activity of Aryl- or Pyridyl-Substituted Fused Imidazoles

Author

Rosaria Bossa, Alessandra Locatelli, Aldo Andreani, Iraklis Galatulas, G Salvatore, and Mirella Rambaldi

Subjects
chemistry.chemical_compound, Benzothiazole, chemistry, Group (periodic table), Stereochemistry, Aryl, General Medicine
Abstract

The syntheses of 4 different fused imidazoles bearing a 2,5-dimethoxyphenyl group or a pyridyl group are reported. All the heterocycles, except 2a , display positive inotropic activity. Some are approximately equipotent with sulmazole, and the imidazo[2,1- b ]benzothiazole that bears a 4-pyridyl group is the most active of whole series.

Published
2010
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34. ChemInform Abstract: Potential Antitumor Agents. Part 24. Synthesis and Pharmacological Behavior of Imidazo(2,1-b)thiazole Guanylhydrazones Bearing at Least One Chlorine

Author

Aldo Andreani, Fraccari A, G Salvatore, Mirella Rambaldi, Rosaria Bossa, Alessandra Locatelli, Iraklis Galatulas, and Alberto Leoni

Subjects
chemistry.chemical_compound, Bearing (mechanical), chemistry, law, Chlorine, chemistry.chemical_element, General Medicine, Thiazole, Combinatorial chemistry, law.invention
Published
2010
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37. Metacognition as a mediator of the effects of impairments in neurocognition on social function in schizophrenia spectrum disorders

Author

Paul H, Lysaker, A M, Shea, K D, Buck, G, Dimaggio, G, Nicolò, M, Procacci, G, Salvatore, and K L, Rand

Subjects
Male, Psychiatric Status Rating Scales, Cross-Sectional Studies, Quality of Life, Schizophrenia, Humans, Female, Schizophrenic Psychology, Middle Aged, Neuropsychological Tests, Cognition Disorders, Social Behavior, Social Adjustment
Abstract

This study explored whether Mastery, a domain of metacognition that reflects the ability to use knowledge about mental states to respond to psychological challenges, mediated the effects of neurocognition on the frequency of social contact and persons' capacity for social relatedness.Participants were 102 adults with schizophrenia or schizoaffective disorder. Neurocognition was represented by a single factor score produced by a principal components analysis of a neurocognitive test battery. Mastery was assessed using the metacognitive assessment scale and social functioning by the quality of life scale.Using structural equation modeling, specifically measured-variable path analysis, a mediational model consisting of neurocognitive capacity linked to mastery and capacity for social relationships and mastery linked with frequency of social contact and capacity for social relatedness showed acceptable fit to the observed data. This persisted after controlling for negative and cognitive symptoms.Results suggest that certain forms of metacognition mediate the influence of neurocognition upon function in schizophrenia.

Published
2010

38. [Hernia repair and local anesthesia. Results of a controlled randomized clinical trial]

Author

F, Milone, G, Salvatore, M, Leongito, M, Milone, Milone, F, Salvatore, Giuseppe, Leongito, M, and Milone, M.

Subjects
Male, Wound Healing, Treatment Outcome, Ambulatory Surgical Procedures, Patient Satisfaction, Outpatients, Humans, Hernia, Inguinal, Prospective Studies, Anesthetics, Local, Anesthesia, Spinal, Anesthesia, Local
Abstract

In the past, general and spinal anesthesia were used for hernia surgery, but nowadays local anesthesia has become the method of choice for hernia repair, especially in outpatient patients. The one-day surgery is sufficient in the management of this pathology. The advantages of local anesthesia are simplicity, safety, extended postoperative analgesia, early mobilization, lack post-anesthesia effects, and low costs. From January 2004 to December 2008 we observed 297 male patients with inguinal hernia. These patients were divided, with rigorous chronological order of hospital admission, in two study groups, different for anesthetic techniques used. Our controlled randomized clinical trial examines the effectiveness of local anesthesia to reduce the time of hospitalization, without alteration of results, and particularly the degree of satisfaction of patients surgical treated for inguinal hernia.

Published
2010

39. The PTC oncogene is able to dedifferentiate a rat thyroid epithelial cell line in culture

Author

Rosa Marina Melillo, Massimo Santoro, M. Grieco, Alfredo Fusco, Aniello Cerrato, Giancarlo Vecchio, and Corrisp G. Salvatore

Subjects
endocrine system, Oncogene, medicine.medical_treatment, Cellular differentiation, Thyroid, Biology, medicine.disease_cause, Virology, Viral vector, Thyroid carcinoma, medicine.anatomical_structure, Cell culture, Cancer research, medicine, General Earth and Planetary Sciences, Thyroglobulin, General Agricultural and Biological Sciences, Carcinogenesis, General Environmental Science
Abstract

We have recently cloned a new oncogene from human papillary thyroid carcinomas, which we have designatedPTC. This oncogene consists of a chimeric gene, the 5′-end of which corresponds to a gene of unknown function, designated H4, while the 3′ portion corresponds to the tyrosine kinase domain of theRET proto-oncogene. We constructed a retroviral vector containing thePTC oncogene under the transcriptional control of the Moloney LTR, and then produced the corresponding defective retrovirus by transfecting the retroviral vector onto Psi-2 cells. We subsequently used this retrovirus to infect a differentiated rat thyroid cell line (PC-C1-3) which is dependent on TSH for growth. Upon infection with thePTC virus the PC-C1-3 cells no longer depended on TSH for growth. Furthermore, the infected cells lost completely their differentiated functions,i.e. thyroglobulin and TSH-receptor genes expression and iodide uptake. However, they retained their non malignant phenotype in that they were not able to grow in semisolid media nor in the athymic mice. The introduction in the PC-C1-3 cell line of both thePTC and the activated viral Ha-ras oncogenes resulted in the appearance of a completely undifferentiated and malignant phenotype. These results demonstrate that:a) ThePTC oncogene, which plays an important role in human thyroid carcinogenesis, is also able to induce the complete dedifferentiation of rat thyroid cellsin vitro;b) Two cytoplasmic oncogenes (Ha-ras andPTC) cooperate in the induction of a fully malignant phenotype of a thyroid differentiated cell line.

Published
1992
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40. Myocyte apoptosis and regeneration in the development of left ventricular pressure overload hypertrophy (LVH) in humans

Author

S. DI SOMMA, G. CUDEMO, G. SALVATORE, M. CAPUTO, M. DI BENEDETTO, F. NOVIELLO, C. MAIELLO, G. CAPUTO, M. COTRUFO, J. KAJSTURA, O. DE DIVITIIS, P. ANVERSA, MAROTTA, MARCELLO, S., DI SOMMA, G., Cudemo, G., Salvatore, M., Caputo, M., DI BENEDETTO, F., Noviello, Marotta, Marcello, C., Maiello, G., Caputo, M., Cotrufo, J., Kajstura, O., DE DIVITIIS, and P., Anversa

Published
1999

41. Acquisition of Helicobacter pylori infection in childhood: a risk for gastric carcinogenesis

Author

NARDONE, GERARDO ANTONIO PIO, ROCCO, ALBA, STAIBANO, STEFANIA, T. Balzano, V. Donofrio, E. Mezza, G. Salvatore, G. Ventriglia, ML Basile, B. Grazioli, G. De Rosa, G. Budillon, Nardone, GERARDO ANTONIO PIO, Rocco, Alba, Staibano, Stefania, T., Balzano, V., Donofrio, E., Mezza, G., Salvatore, G., Ventriglia, Ml, Basile, B., Grazioli, G., De Rosa, and G., Budillon

Published
1999

42. Identification of hormonogenic tyrosines in fragment 1218-1591 of bovine thyroglobulin by mass spectrometry. Hormonogenic acceptor Tyr-1291 and donor Tyr-1375

Author

F. Gentile, G. Mamone, A. Malorni, G. Salvatore, FERRANTI, PASQUALE, F., Gentile, Ferranti, Pasquale, G., Mamone, A., Malorni, and G., Salvatore

Subjects
hormonogenic tyrosines, thyroglobulin, mass spectrometry
Abstract

A fragment of bovine thyroglobulin encompassing residues 1218-1591 was prepared by limited proteolysis with thermolysin and continuous-elution polyacrylamide gel electrophoresis in SDS. The reduced and carboxymethylated peptide was digested with endoproteinase Asp-N and fractionated by reverse-phase high performance liquid chromatography. The fractions were analyzed by electrospray and fast atom bombardment mass spectrometry in combination with Edman degradation. The post-translational modifications of all seven tyrosyl residues of the fragment were characterized at an unprecedented level of definition. The analysis revealed the formation of: 1) monoiodotyrosine from tyrosine 1234; 2) monoiodotyrosine, diiodotyrosine, triiodothyronine (T-3), and tetraiodothyronine (thyroxine, T-4) from tyrosine 1291; and 3) monoiodotyrosine, diiodotyrosine, and dehydroalanine from tyrosine 1375. Iodothyronine formation from tyrosine 1291 accounted for 10% of total T-4 of thyroglobulin (0.30 mol of T-4/mol of 660-kDa thyroglobulin), and 8% of total T-3 (0.08 mol of T-3/mol of thyroglobulin). This is the first documentation of the hormonogenic nature of tyrosine 1291 of bovine thyroglobulin, as thyroxine formation at a corresponding site was so far reported only in rabbit, guinea pig, and turtle thyroglobulin. This is also the first direct identification of tyrosine 1375 of bovine thyroglobulin as a donor residue. It is suggested that tyrosyl residues 1291 and 1375 may support together the function of an independent hormonogenic domain in the mid-portion of the polypeptide chain of thyroglobulin.

Published
1997

46. Microcystin diversity in a 'Planktothrix rubescens' population from Lake Albano (Central Italy)

Author

Roberto Mazza, Serena Melchiorre, Valentina Messineo, Sara Bogialli, Daniela Mattei, G. Capelli, Milena Bruno, R. Salzano, G. Salvatore, Messineo, V, Mattei, D, Melchiorre, S, Salvatore, G, Bogialli, S, Salzano, R, Mazza, Roberto, Capelli, G, Bruno, M., Mazza, R, and Capelli, Giuseppe

Subjects
Cyanobacteria, Lake Albano, microcystin, Microcystins, Cyanotoxins, Population, Water source, Bacterial Toxins, Zoology, Fresh Water, Microcystin, Biology, Toxicology, Peptides, Cyclic, Planktothrix rubescens, Mass Spectrometry, Albano lake, Crater lake, Water Pollutants, education, Chromatography, High Pressure Liquid, chemistry.chemical_classification, Oscillatoria rubescens, education.field_of_study, Ecology, Species diversity, cyanotoxins, lake albano, microcystins, planktothrix rubescens, biology.organism_classification, chemistry, Italy, Seasons, cianotoxin, Water Microbiology, Environmental Monitoring
Abstract

Microcystin diversity in a Planktothrix rubescens population from Lake Albano (Central Italy). Toxicon 48, 160-174. Elsevier. Abstract The cyanobacterium Planktothrix rubescens Anagnostidis & Komarek (previously Oscillatoria rubescens DC ex Gomont) is present in several Italian lakes and it is known to produce cyanotoxins. The dynamics and toxin production of P. rubescens population in Lake Albano, a volcanic crater lake in Central Italy, has been studied for 5 years (January 2001–April 2005). Winter–spring super.cial blooms with frequent scums were observed every year. Total microcystin (MC) levels were measured from April 2004 to October 2005 by liquid chromatography-tandem mass spectrometry. MC levels up to 14.2 mg/l were measured, with high concentrations found in summer at a 20–25m depth. The intracellular toxin content varied between 1.5 (surface, January 2004) and 0.21 pg/cell (surface, May 2004). Six different MCs were detected, the most abundant being two desmethyl-MC-RR isomers. Of the 13 water wells monitored in the Lake Albano area, two of them showed MC contamination during winter, con.rming the ability of these toxins to migrate through groundwater towards public water sources. These results highlight the need for further studies on the mobility and fate of these pervasive cyanobacterial toxins.

Published
2006

47. Melaleuca alternifolia essential oil possesses potent anti-staphylococcal activity extended to strains resistant to antibiotics

Author

T. Ceddia, Anna Maria Ferrini, Paolo Aureli, G. Salvatore, Brunello Oliva, Rosa Sessa, E. Pontieri, E. Piccirillp, and Veruscka Mannoni

Subjects
Staphylococcus aureus, TTO, medicine.drug_class, Fusidic acid, Immunology, Antibiotics, Mupirocin, Biology, Staphylococcal infections, medicine.disease_cause, anti-staphylococcal activity, Microbiology, Melaleuca alternifolia, TTO, terpinen-4-ol, anti-staphylococcal activity, resistant staphylococci, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Drug Resistance, Bacterial, Oils, Volatile, medicine, resistant staphylococci, Immunology and Allergy, Pharmacology, terpinen-4-ol, Terpenes, Melaleuca alternifolia, Melaleuca, melaleuca alternifolia, tto, medicine.disease, biology.organism_classification, humanities, Anti-Bacterial Agents, chemistry, 030220 oncology & carcinogenesis, Mutation, Linezolid, Vancomycin, 030215 immunology, medicine.drug
Abstract

Melaleuca alternifolia Cheel essential oil (TTO) and its major component terpinen-4-ol were examined against a large number of clinical isolates of Staphylococcus aureus to establish their anti-staphylococcal activities. Classic and established procedures were used to study M.I.C., time-kill curves, synergism and mutational frequency. The anti-staphylococcal activity of terpinen-4-ol and TTO were superior to those of antibiotics belonging to the major families (all the tested drugs are for topical use or included in ointments, eye drops or used during surgery); terpinen 4-ol and TTO were active against strains resistant to mupirocin, fusidic acid, vancomycin, methicillin and linezolid. TTO and terpinen-4-ol were bactericidal as revealed by time-kill curves; the frequency of mutational frequency to TTO was < 2.9×109. The study demonstrates good anti-staphylococcal activity of TTO and terpinen-4-ol against a large number of S.aureus isolates and suggests the possible application of these agents for topical treatment of staphylococcal infections. This is the first extensive study on the anti-staphylococcal activity of TTO. The results suggest that this compound may have application as a topical agent for the control of superficial staphylococcal infections, including activity against organisms resistant to antibiotics which can be used, or are specific, for topical use.

Published
2006

50. [Long-term evaluation of the endoscopic treatment of gastric polyps]

Author

M, Bellini, R, Di Palma, S, Lombardi, G, Ferraiuolo, and G, Salvatore

Subjects
Adult, Male, Polyps, Time Factors, Stomach Neoplasms, Gastroscopy, Humans, Female, Middle Aged, Aged
Abstract

The authors intend to evaluate the long-term efficacy of endoscopic treatment of gastric polyps.They report their experience in 5000 upper gastro intestinal endoscopies performed between 1985 and 1998. The method used aimed to evaluate the distribution of polyps by sex and age, the frequency of various histological types and the incidence of complications in relation to histological type and the size of the polyps. The authors also analysed the indications and criteria of choice between endoscopic treatment and surgery and they calculated the incidence of malignant neoplasm and complications in relation to the endoscopic method used, as well as the incidence of relapse at the medium and long-term follow-up. They searched for the presence of neoplasms in the follow-up and compared their personal experience with data from international literature.The results obtained show that non-surgical treatment of gastric polyps is resolutive in most cases. The endoscopic resection of polyps was performed using a polypectomy loop. In patients converted to surgery, the necessity for the operation was caused by an unexpected hemorrhage that could not be controlled using endoscopic treatment. In this case, the operation consisted of resecting the entire wall of the lesion, including an extemporary histological analysis.The authors' experience allows them to state that endoscopic treatment of this gastric pathology is efficacious and free from risks and complications if stringent patient selection criteria are used (dimensions, morphological characteristics of the lesion) and control procedures over time suited to the potential malignancy of each histological type are carried out.

Published
2001

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