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The aim of the present study was to compare the efficacy and safety of fosfomycin combinational therapy with other antibiotics for the treatment of infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP). This retrospective cohort study examined 104 cases of sepsis caused by CRKP occurring between January 2012 and November 2014 in Shanghai Tenth People's Hospital. Three categories of patient outcome were assessed: Survival/mortality, duration of intensive care unit stays and duration of medical ventilation. Univariate ordinal analyses were adopted to evaluate the correlations between outcome and treatment. A total of 104 patients with physician-diagnosed CRKP were involved in the study. The overall mortality rate was 25.0%. The majority of the infections (84; 80.8%) were hospital acquired. Critical infections received more than one active antibiotic as therapy. Patients treated with fosfomycin combinational therapy were less likely to fail therapy (OR: 4.71, 95% CI: 1.03-21.65, P=0.034) and tended to have a shorter duration of mechanical ventilation. Gender (OR: 4.35, 95% CI: 1.08-3.60, P=0.037), history of chronic obstructive pulmonary disease (OR: 9.35, 95% CI: 0.06-0.19, P=0.007) and peripheral catheter use (OR: 3.00, 95% CI: 0.07-0.19, P=0.002) are risk factors for clinical outcome. Therefore, the use of fosfomycin combinational therapy for treatment of infection due to CRKP appears to be associated with improved survival rate.

Light-flavour Baijiu is a type of Chinese liquor with a pure and mild flavour produced by traditional spontaneous solid-state fermentation. The flavour of this liquor has been found to vary in the different periods of annual production. To explore the factors affecting flavour, the microbiota of the surrounding environment, starter and fermentation process in different periods were investigated. Results showed that the ester content and acidity of light-flavour Baijiu were significantly lower when annual production was resumed after a summer break. HCA plot of volatile flavour profile and bacterial PCoA results indicated that the differences occurred at later stages, mainly due to different structures of Lactobacillus. Correlation analysis by O2PLS indicated that Lactobacillus positively correlated with esters. Species-level analysis showed that the lack of L. acetotolerans on the surface of the jar might cause a lag in fermentation and lower ester content. Thereafter, L. acetotolerans was revived during fermentation and enriched on the surface of the jar, which promoted ester formation. As important sources of L. acetotolerans, the air and fermentation jars played a critical role during fermentation. Therefore, this systematic study on environmental microbial ecology is valuable for quality control and to explore environmental microbiota functions during spontaneous fermentation.

Harmful low molecular weight substances in fifteen commercially available disposable cups were qualitatively analyzed. Contents of several suspected low molecular weight substances containing 2,6-Di-tert-butyl-4-methylphenol,Oleamide, Dibutyl phthalate in 15 disposable cups were quantitatively analyzed. The amount of igration of low molecular weight substances (DBP) in three food simulants was analyzed.

In this paper, nano TiO2 loaded on activated carbon fiber(ACF) was prepared by hydrothermal method as TiO2/ACF photocatalytic.The material crystal structure, the superficial appearance of catalyst, were analyzed and measured by XRD and SEM images.Moreover, it used for photocatalytic oxidation As(Ⅲ).The effect of pH on the oxidation of As(Ⅲ) was studied. The oxidation of As(Ⅲ) efficiency increasing markedly with pH, and the catalytic efficiency is much higher in the alkaline environment than in the acidic environment.

Al–Sn co-doped ZnO thin films were fabricated onto quartz glass substrates by the sol-gel method. The surface morphology, electrical and optical properties at different post-deposition heating temperatures were investigated. The grains of preferred c-axis showed a well-mixed microstructure and the peak height was enhanced with the post-deposition heating temperature increasing from 400°C to 600°C. Doped films showed a preferential orientation along the (002) plane, while the preferential orientation changed to the (101) plane when temperature was higher than 500°C. The lowest resistivity 6×10–3Ω•cm was observed from samples made at 500°C, with an average 91.2% optical transmittance in the visible range. In this study, optical band gap of all the doped films were broadened, regardless of post–deposition heating temperature.

A polyurethane resin catalyst with the cross-linking silver (Ag) ion is successfully synthesized in this study, and its use as a catalyst in electroless copper deposition is also analyzed. FT-IR, SEM, EDX and electrochemical open circuit potential-time (OCP-t) technique are used to analyze the structure of the catalyst, the process of catalyzing copper deposition and induced rate of the electroless copper deposition. We also demonstrate that the polyurethane resin catalyst containing silver ion can be screen printed onto the PET substrate, then, a Cu pattern is successfully fabricated on the PET after electroless copper plating.

In this paper, the silicone rubber composed of carbon fibers was prepared. The influence of different concentration of carbon fibers on the conductivity, electromagnetic shielding interference effectiveness property of the silicone rubber was discussed from the point of view of condition of carbon fiber and silicone rubber. The results showed that there existed the extreme conductivity and shielding effectiveness (SE) across the tested frequency range from 2.6 GHz to 3.95 GHz of silicone rubber composites filled with carbon fibers. When the content of the carbon fibbers was 50 parts per hundred of rubber (phr), the SE values of composites were typically above 63 dB and close to the extremum. The compact packing structure of carbon fibers does not play an important role in improved the conductivity of composite. The SE of the composite depends on the conductivity of composite.

Ni-P alloy electrode was prepared by electroless plating on the Cu-Zn substrate. The surface morphology and textural properties of electrode were characterized by Scanning electron microscope(SEM), Energy dispersive spectroscopy(EDS) and X-ray diffraction(XRD). The performance of Ni-P alloy electrode was tested by cyclic voltammetry, chronoamperometry and electrochemical impedance spectroscopy.The results of cyclic voltammetry showed that: At room temperature, Ni-P alloy electrode had significant catalytic effect on the electrocatalytic oxidation of ethanol in alkaline solution. Results of chronoamperometry and electrochemical impedance spectroscopy further confirmed the catalytic effect of Ni-P alloy electrode on the electrochemical oxidation of ethanol.

As a simple and useful approach, vapor-phase photografting acrylic acid was used to modify the surface of PET films. Catalyst of silver nanoparticles was distributed on the photografting PET films equably after reducing by ascorbic acid. Topography of the pristine, grafting and metallized PET films was characterized by scanning electron microscope (SEM). XRD and FTIR-ATR were also used to analyze the electroless plating copper layer and the grafting PET film respectively.

In this paper，electroless Ni-P plating on copper substrate at 50 °C in ultrasonic field was carried out. The frequency of ultrasonic waves was 40 kHz. The effect of ultrasonic on the composition, plating rate and morphology of Ni-P deposite was investigated at the ultrasonic power of 40, 70 and 100 W. The experimental results showed Ni-P deposit could not be obtained without ultrasonic field at 50 °C. The content of nickel and the thickness of Ni-P deposit increased with the ultrasonic waves power increase. Ultrasonic irradiation power remarkably refines the nodule size of Ni-P particles. The collapse of cavities in solution seems to suppress the Z-direction growth of the nodule.

A 53-year-old man presented to our department with acute urinary retention and an approximate 8-year history of frequent urination, dysuria, poor urinary stream and nocturia. His prostate-specific antigen (PSA) values were normal (

Anodic coatings were obtained by micro-arc oxidation on AZ91HP magnesium alloys in a solution containing 10 g/L NaOH and 8 g/L phytic acid. The effects of electric parameters including frequency, final voltage, duty cycle and current density on the corrosion resistance of anodic coatings formed on the magnesium alloys were investigated by using an orthogonal experiment of four factors with three levels. The results show that the final voltage plays a main role on the coating properties. The orders of affecting corrosion resistance and coating thickness are separately ranked from high to low as, final voltage>duty cycle>current density>frequency and final voltage>current density>frequency>duty cycle. The final voltage influences the corrosion resistance of the anodized samples mainly by changing the surface morphology and coating thickness.

The aim of the present study was to compare the efficacy and safety of fosfomycin combinational therapy with other antibiotics for the treatment of infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP). This retrospective cohort study examined 104 cases of sepsis caused by CRKP occurring between January 2012 and November 2014 in Shanghai Tenth People's Hospital. Three categories of patient outcome were assessed: Survival/mortality, duration of intensive care unit stays and duration of medical ventilation. Univariate ordinal analyses were adopted to evaluate the correlations between outcome and treatment. A total of 104 patients with physician-diagnosed CRKP were involved in the study. The overall mortality rate was 25.0%. The majority of the infections (84; 80.8%) were hospital acquired. Critical infections received more than one active antibiotic as therapy. Patients treated with fosfomycin combinational therapy were less likely to fail therapy (OR: 4.71, 95% CI: 1.03–21.65, P=0.034) and tended to have a shorter duration of mechanical ventilation. Gender (OR: 4.35, 95% CI: 1.08–3.60, P=0.037), history of chronic obstructive pulmonary disease (OR: 9.35, 95% CI: 0.06–0.19, P=0.007) and peripheral catheter use (OR: 3.00, 95% CI: 0.07–0.19, P=0.002) are risk factors for clinical outcome. Therefore, the use of fosfomycin combinational therapy for treatment of infection due to CRKP appears to be associated with improved survival rate.

This meta-analysis was conducted to assess the association between fruit and vegetable intake and bladder cancer risk. Eligible studies published up to August 2014 were retrieved both through a computer search of PubMed, Embase and the Cochrane library and through a manual review of references. The summary relative risks with 95% confidence intervals (CIs) for the highest versus the lowest intakes of fruits and vegetables were calculated with random-effects models. Heterogeneity and publication bias were also evaluated. Potential sources of heterogeneity were detected with metaregression. Subgroup analyses and sensitivity analyses were also performed. A total of 27 studies (12 cohort and 15 case-control studies) were included in this meta-analysis. The summary relative risks for the highest versus lowest were 0.84 (95% CI: 0.72-0.96) for vegetable intake and 0.81 (95% CI: 0.73-0.89) for fruit intake. The dose-response analysis showed that the risk of bladder cancer decreased by 8% (relative risk=0.92; 95% CI: 0.87-0.97) and 9% (relative risk=0.91; 95% CI: 0.83-0.99) for every 200 g/day increment in vegetable and fruit consumption, respectively. Sensitivity analysis confirmed the stability of the results. Our findings suggest that intake of vegetables and fruits may significantly reduce the risk of bladder cancer. Further well-designed prospective studies are warranted to confirm these findings.

The Delta-like ligand 4 (Dll4) and Notch signaling pathway plays a key role in embryonic vascular development and tumor growth. In this study, we measured the expression of Dll4 in clear cell renal cell carcinoma (ccRCC) and explored the correlation between Dll4 and ccRCC. We used sh-Dll4 treatment in a nude mouse model to observe the effect that inhibition of the Dll4/Notch pathway had on angiogenesis and vasculogenesis. We found up-regulation of Dll4 to be closely correlated with distant metastasis and worse overall survival. Cox regression analysis showed that Dll4 might be a prognostic marker of ccRCC. Blockade of Dll4/Notch signaling inhibited tumor growth in the mouse model via anti-angiogenesis and anti-vasculogenesis effects. We concluded that Dll4 might be a novel therapeutic target for the treatment of ccRCC.

We systematically investigate the effect of pressure on the magnetic properties of GdCo2B2 on the basis of alternating current (AC) susceptibility, AC heat capacity and electrical resistivity measurements under pressures up to 2.2 GPa. A detailed magnetic phase diagram under pressure is determined. GdCo2B2 exhibits three anomalies that apparently reflect magnetic phase transitions, respectively, at temperatures T C = 20.5 K, T 1 = 18.0 K and T N = 11.5 K under ambient pressure. Under pressures up to 2.2 GPa, these anomalies are observed to slightly increase at T C and T 1, and they coincide with each other above 1.6 GPa. Conversely, they decrease at T N and disappear under pressures higher than 1.4 GPa. The results indicate that the low-temperature magnetic phases can be easily suppressed by pressure. Moreover, the spin-glass-like behavior of GdCo2B2 is examined in terms of magnetization, aging effect and frequency dependence of AC susceptibility. A separation between the zero-field-cooled (ZFC) and field-cooled (FC) magnetization curves becomes evident at a low magnetic field of 0.001 T. A long-time relaxation behavior is observed at 4 K. The freezing temperature T f increases with frequency increasing.

In digital optical computing, optical interconnections are the primitives of algorithm and architecture. In particular, perfect shuffle interconnections, butterfly interconnections, and crossover interconnections are widely studied; not only can they implement some simpler logic operations, they can also constitute more complex and more effective computing systems. Especially, the butterfly interconnection has many advantages over others in implementing digital systems. In this paper, we design an n-bit parallel full adder/subtractor.