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623 results on '"Gandjbakhch, Estelle"'

2. Abatacept/Ruxolitinib and Screening for Concomitant Respiratory Muscle Failure to Mitigate Fatality of Immune-Checkpoint Inhibitor Myocarditis.

Author

Salem, Joe-Elie, Bretagne, Marie, Abbar, Baptiste, Leonard-Louis, Sarah, Ederhy, Stéphane, Redheuil, Alban, Boussouar, Samia, Nguyen, Lee S, Procureur, Adrien, Stein, Frederic, Fenioux, Charlotte, Devos, Perrine, Gougis, Paul, Dres, Martin, Demoule, Alexandre, Psimaras, Dimitri, Lenglet, Timothee, Maisonobe, Thierry, De Chambrun, Marc Pineton, Hekimian, Guillaume, Straus, Christian, Gonzalez-Bermejo, Jesus, Klatzmann, David, Rigolet, Aude, Guillaume-Jugnot, Perrine, Champtiaux, Nicolas, Benveniste, Olivier, Weiss, Nicolas, Saheb, Samir, Rouvier, Philippe, Plu, Isabelle, Gandjbakhch, Estelle, Kerneis, Mathieu, Hammoudi, Nadjib, Zahr, Noel, Llontop, Claudia, Morelot-Panzini, Capucine, Lehmann, Lorenz, Qin, Juan, Moslehi, Javid J, Rosenzwajg, Michelle, Similowski, Thomas, and Allenbach, Yves

Subjects
Lung, Clinical Research, Rare Diseases, Humans, Myocarditis, Immune Checkpoint Inhibitors, Abatacept, Antineoplastic Agents, Immunological, Myotoxicity, Myositis, Respiratory Muscles, Oncology and Carcinogenesis
Abstract

Immune-checkpoint-inhibitor (ICI)-associated myotoxicity involves the heart (myocarditis) and skeletal muscles (myositis), which frequently occur concurrently and are highly fatal. We report the results of a strategy that included identification of individuals with severe ICI myocarditis by also screening for and managing concomitant respiratory muscle involvement with mechanical ventilation, as well as treatment with the CTLA4 fusion protein abatacept and the JAK inhibitor ruxolitinib. Forty cases with definite ICI myocarditis were included with pathologic confirmation of concomitant myositis in the majority of patients. In the first 10 patients, using recommended guidelines, myotoxicity-related fatality occurred in 60%, consistent with historical controls. In the subsequent 30 cases, we instituted systematic screening for respiratory muscle involvement coupled with active ventilation and treatment using ruxolitinib and abatacept. The abatacept dose was adjusted using CD86 receptor occupancy on circulating monocytes. The myotoxicity-related fatality rate was 3.4% (1/30) in these 30 patients versus 60% in the first quartile (P < 0.0001). These clinical results are hypothesis-generating and need further evaluation.SignificanceEarly management of respiratory muscle failure using mechanical ventilation and high-dose abatacept with CD86 receptor occupancy monitoring combined with ruxolitinib may be promising to mitigate high fatality rates in severe ICI myocarditis. See related commentary by Dougan, p. 1040. This article is highlighted in the In This Issue feature, p. 1027.

Published
2023

3. PFMG2025–integrating genomic medicine into the national healthcare system in France

Author

Abadie, Caroline, Abderrahmane, Aldja, Abdous, Ouarda, Abel, Carine, Ackermann, Oanez, Acquaviva, Cécile, Ader, Flavie, Adham, Salma, Adjaoud, Dalila, Afenjar, Alexandra, Aladjidi, Nathalie, Alary, Anne-Sophie, Albarel, Frédérique, Albert, Sabrina, Allard, Lise, Allix, Ingrid, Alunni, Violaine, Amado, Inês F., Amouroux, Cyril, André, Nicolas, Angelini, Chloé, Anheim, Mathieu, Sanfelliz, Ignacio Antolin, Aparicio, Thomas, Arfeuille, Chloé, Arlet, Jean-Benoît, Arnaud, Lionel, Arnaud, Pauline, Arnold, Guilhem, Attie-Bitach, Tania, Aubert-Mucca, Marion, Audo, Isabelle, Audrezet, Marie-Pierre, Auroux, Maxime, Auzanneau, Céline, Ayrignac, Xavier, Ba, Ibrahima, Bachelot, Anne, Bacq, Delphine, Bacrot, Séverine, Bader-Meunier, Brigitte, Baer, Sarah, Baert-Desurmont, Stéphanie, Bal-Theoleyre, Laurence, Balogoun, Ralyath, Baltzinger, Philippe, Banneau, Guillaume, Bar, Claire, Barbet, Audrey, Barcia, Giulia, Barjhoux, Laure, Barlier, Anne, Barlogis, Vincent, Barritault, Marc, Barth, Magalie, Barthod-Malat, Aurore, Baudouin-Cornu, Peggy, Baujat, Geneviève, Baurand, Amandine, Bay, Jacques-Olivier, Beau-Faller, Michèle, Beaudoin, Jean-Christophe, Bellance, Rémi, Bellanné-Chantelot, Christine, Bellera, Carine, Belot, Alexandre, Ben Abdeljelil, Raihane, Ben Sghaier, Rihab, Benadiba, Joy, Benard, Stéphanie, Beneteau, Claire, Benistan, Karelle, Benkerdou, Fouzia, Benkirane, Mehdi, Benoist, Jean-François, Benusiglio, Patrick R., Bergès, Camille, Bergougnoux, Anne, Bernadach, Maureen, Bernard, Emilien, Bernard, Valérie, Bernard, Virginie, Beroug, Dounia, Berrard, Aurélie, Bertherat, Jérôme, Berthet, Pascaline, Berthier, Clotilde, Bertholet-Thomas, Aurélia, Bertocchio, Jean-Philippe, Bertucci, François, Besse, Céline, Besse-Pinot, Elsa, Bessis, Didier, Beuvain, Pauline, Bezieau, Stéphane, Bidart, Marie, Bièche, Ivan, Biehler, Margaux, Bienvenu, Thierry, Bilan, Frédéric, Billon, Clarisse, Binquet, Christine, Bismuth, Elise, Bizaoui, Varoona, Blanc, Pierre, Blanché, Hélène, Blay, Jean-Yves, Bloch, Adrien, Bloch, Gilles, Bloch-Zupan, Agnes, Bocquet, Béatrice, Boedec, Morgane, Boileau, Catherine, Boissinot, Maureen, Boland, Anne, Bolze, Pierre-Adrien, Bonadona, Valérie, Bonastre, Julia, Bonello-Palot, Nathalie, Bonnard, Adeline-Alice, Borie, Raphaël, Botsen, Damien, Bouattour, Mohamed, Bouctot, Marion, Bouhours-Nouet, Natacha, Bouligand, Jérôme, Bouras, Ahmed, Bourgeron, Thomas, Bourges, Jean-Louis, Bourrat, Emmanuelle, Boursier, Guilaine, Bousquet, Guilhem, Bousquet, Philippe-Jean, Boussion, Simon, Boutaud, Lucile, Boutin, Julian, Bouvagnet, Patrice, Bouvattier, Claire, Boyault, Sandrine, Brac de la Perriere, Aude, Brahmi, Mehdi, Brard, Valentine, Brasseur, Mathilde, Brazzalotto, Nadège, Brémond-Gignac, Dominique, Briand-Suleau, Audrey, Briet, Claire, Bringuier, Pierre-Paul, Bris, Céline, Brischoux-Boucher, Elise, Brochard, Karine, Broly, Martin, Brosseau, Laura, Bruel, Ange-Line, Brunelle, Perrine, Bubien, Virginie, Buecher, Bruno, Buffet, Alexandre, Buisson, Adrien, Burglen, Lydie, Des Roziers, Cyril Burin, Burnichon, Nelly, Busa, Tiffany, Cabart, Mathilde, Cabet, Sara, Caille-Benigni, Charlotte, Caillot, Claire, Calvin, Christophe, Cambon-Thomsen, Anne, Cances, Claude, Cantan, Alexandre, Carausu, Liana, Carbasse, Aurélia, Carbonneil, Cédric, Cariou, Bertrand, Caron, Olivier, Carras, Sylvain, Cartalat, Stéphanie, Cassinari, Kévin, Castelle, Martin, Castéra, Laurent, Castinetti, Frédéric, Catteau, Julie, Caumes, Roseline, Caux, Aurélien, Cavaillé, Mathias, Cavé, Hélène, Caye-Eude, Aurélie, Cazeneuve, Cécile, Celse, Tristan, Celton, Noémie, Cenni, Camille, Cévost, Jasmin, Chaabna, Rania, Chabrol, Brigitte, Challet, Ilyas, Chalumeau, Clélia, Chambon, Pascal, Chansavang, Albain, Chanson, Jean-Baptiste, Chapelant, Sébastien, Charbit-Henrion, Fabienne, Charles, Perrine, Charrière, Sybil, Charron, Philippe, Chassaing, Nicolas, Chatron, Nicolas, Chaumette, Boris, Chaussain, Catherine, Chaussenot, Annabelle, Cheillan, David, Chenavier, Olivier, Chesneau, Bertrand, Chevalier, Louise-Marie, Chomienne, Christine, Chougnet, Cécile, Christin-Maitre, Sophie, Chuet, Marine, Clappier, Emmanuelle, Clet, Johanna, Cloteau, Mélanie, Cluzeau, Thomas, Cogan, Guillaume, Cogné, Benjamin, Cohen, Alicia, Cohen, Camille, Cohen-Haguenauer, Odile, Cohen-Solal, Martine, Colas, Chrystelle, Colin, Estelle, Collet, Corinne, Collin-Chavagnac, Delphine, Colliou, Eloïse, Collonge-Rame, Marie-Agnès, Colmard, Maxime, Coopman, Stéphanie, Coppin, Lucie, Coquan, Elodie, Cormier-Daire, Valérie, Corradini, Nadège, Corsini, Carole, Cossée, Mireille, Coste, Thibault, Cotteret, Sophie, Cottet, Rachel, Coubes, Christine, Coulet, Florence, Couque, Nathalie, Couratier, Philippe, Courbebaisse, Marie, Courbette, Olivier, Courdier, Cécile, Coursimault, Juliette, Courtin, Thomas, Courtois, Lucien, Coury, Fabienne, Coutos-Thévenot, Laure, Coutton, Charles, Creveaux, Isabelle, Crickx, Etienne, Crivelli, Louise, Cuggia, Marc, Cuisset, Laurence, Curcio, Hubert, Curie, Aurore, Cusin, Veronica, Da Costa, Noémie, Da Cruz, Lionel, Dahlen, Eric, Dardenne, Antoine, Dauriat, Benjamin, Dausse, Nell, De Becdelièvre, Alix, De Fraipont, Florence, De La Cruz, Elisa, De la Motte Rouge, Thibault, De Montgolfier, Sandrine, De Pauw, Antoine, De Reyniès, Aurélien, De Sainte Agathe, Jean-Madeleine, De Tayrac, Marie, Defachelles, Anne-Sophie, Degaud, Michaël, Deiller, Caroline, Delabesse, Eric, Delachaux, Leslie, Delahaye-Duriez, Andrée, Deleuze, Jean-François, Delhomelle, Hélène, Delmas, Christelle, Delnatte, Capucine, Delorme, Catherine, Delorme, Richard, Demeer, Bénédicte, Demilly, Caroline, Denizeau, Philippe, Denjoy, Isabelle, Denommé-Pichon, Anne-Sophie, Depienne, Christel, Derive, Nicolas, Dervillé, Flora, Portes, Vincent Des, Desguerre, Isabelle, Desnous, Béatrice, Desseignes, Camille, Devillard, Françoise, Deville, Manjula, Dewulf-Pasz, Nelly, Dhaenens, Claire-Marie, Dietrich, Klaus, Dieux, Anne, Diop, Mody, Disse, Emmanuel, Djaber, Samir, Cao, Christine Do, Dollfus, Hélène, Domenach, Louis, Donadieu, Jean, Donadille, Bruno, Dougé, Aurore, Dreyfus, Hélène, Drunat, Séverine, Dubois-Laforgue, Danièle, Dubourg, Christele, Dubucs, Charlotte, Dubus, Jean-Christophe, Duchmann, Matthieu, Ducray, François, Ducrotverdun, Marion, Duffaud, Florence, Duffourd, Yannis, Dufour, William, Duhil de Bénazé, Gwénaelle, Dulac, Yves, Dunand, Olivier, Dunoyer de Segonzac, Denis, Dupain, Célia, Duployez, Nicolas, Dupré, Anaïs, Dupré, Aurélien, Dupuis-Girod, Sophie, Duquet, Romain, Durand, Alice, Durand, Benjamin, Durand-Zaleski, Isabelle, Durando, Xavier, Durr, Alexandra, Eberst, Lauriane, Edery, Patrick, Egloff, Matthieu, El Chehadeh, Salima, El Khattabi, Laïla, Engel, Camille, Entresangle, Mathilde, Espérou, Hélène, Esselin, Florence, Etancelin, Pascaline, Evrevin, Clémence, Ewenczyk, Claire, Eychene, Alain, Eychenne, Thomas, Ezaru, Andra, Fabry, Vincent, Faivre, Laurence, Faoucher, Marie, Faure, Clémentine, Fauré, Julien, Fauret-Amsellem, Anne-Laure, Feigerlova, Eva, Feillet, François, Fenwarth, Laurène, Férec, Claude, Fergelot, Patricia, Ferrari, Anthony, Ferraro-Peyret, Carole, Feugeas, Jean-Paul, Fieschi, Claire, Fievet, Alice, Fila, Marc, Fillatre, Rémi, Filser, Mathilde, Fin, Bertrand, Fiore, Mathieu, Firmin, Nelly, Flandrin-Gresta, Pascale, Flechon, Aude, Fournier, Benjamin, Fragny, Cécile, Francois-Heude, Marie-Céline, Francou, Bruno, Frébourg, Thierry, Fressart, Véronique, Frétigny, Mathilde, Funalot, Benoit, Fusaro, Mathieu, Gaignard, Pauline, Gandjbakhch, Estelle, Ganne, Benjamin, Garde, Aurore, Gatinois, Vincent, Gaucher, Céline, Gaudillat, Léa, Gaulard, Philippe, Gauthier, Lucas, Gay-Bellile, Mathilde, Geneste, Damien, Geneviève, David, Genin, Emmanuelle, Genoux, Sandrine, Geoerger, Birgit, Geoffroy, Véronique, Georget, Mathieu, Gérard, Bénédicte, Gertych, Witold, Halem, Souad Gherbi, Ghorab, Karima, Gille, Romane, Gillet, Charlène, Gillibert-Yvert, Marion, Gilly, Olivier, Gimenez-Roqueplo, Anne-Paule, Giraud, Sophie, Girerd, Barbara, Girodon, François, Glazunova, Olga, Gobert, Delphine, Goizet, Cyril, Gokce-Samar, Zeynep, Golmard, Lisa, Gomez-Roca, Carlos, Gonzales, Emmanuel, Gorce, Magali, Gorenstein, Marie-Clémence, Gorrichon, Kévin, Gottrand, Frédéric, Gouas, Laetitia, Gourdon, Stéphanie, Gourdy, Pierre, Gouronc, Aurélie, Goursaud, Claire, Gousse, Gaëlle, Gouy, Evan, Goze-Martineau, Odile, Gozlan, Diane, Grabli, David, Gras, Margaux, Grelet, Maude, Gressin, Laetitia, Grivel, Nathalie, Grotto, Sarah, Grouthier, Virginie, Grunenwald, Solange, Grunewald, Olivier, Gueguen, Paul, Guérin, Cécile, Guerrot, Anne-Marie, Guey, Stéphanie, Guffon, Nathalie, Guichet, Agnès, Guièze, Romain, Guillaud-Bataille, Marine, Guillemin, Francis, Guillerm, Erell, Guillermin, Yann, Guillet-Pichon, Virginie, Guillou, Isabelle, Guimbaud, Rosine, Guimier, Anne, Guissart, Claire, Guittet, Eric, Guy, Nathalie, Hadchouel, Alice, Abdallah, Hamza Hadj, Hadj-Rabia, Smail, Hadjadj, Samy, Hage-Sleiman, Mehdi, Haioun, Corinne, Halawi, Sara, Hamza, Abderaouf, Hanau, Perrine, Hanna, Nadine, Harbuz, Radu, Hardy, Gaëlle, Hauspie, Carine, Hayette, Sandrine, Heard, Jean-Michel, Heiblig, Maël, Heide, Solveig, Heidet, Laurence, Henry, Marcia, Hentgen, Véronique, Héron, Bénédicte, Héron, Delphine, Hervé, Dominique, Herzig, Anthony, Hirsch, Pierre, Hommais, Antoine, Honnorat, Jérôme, Horta, Edgar, Houdayer, Claude, Houillier, Pascal, Huet, Sarah, Hugot, Jean-Pierre, Huguenin, Yoann, Humbert, Marc, Humbert-Asensio, Marie-Laure, Huot, Laure, Ifrah, Norbert, Illouz, Frédéric, Imbard, Apolline, Imbert-Bouteille, Marion, Isambert, Nicolas, Isidor, Bertrand, Italiano, Antoine, Itzykson, Raphaël, Jaillard, Sylvie, Jamilloux, Yvan, Janin, Alexandre, Januel, Louis, Javelot-Jacquelin, Cécile, Jeanne, Médéric, Jedraszak, Guillaume, Jéru, Isabelle, Jeunemaitre, Xavier, Jeziorski, Eric, Jobic, Florence, Joly, Philippe, Jonard, Laurence, Jondeau, Guillaume, Jones, Natalie, Jouannic, Jean-Marie, Jouinot, Anne, Jouk, Pierre-Simon, Jourdy, Yohann, Jousselin, Kévin, Jouvenceau, Anne, Jubert, Charlotte, Julia, Sophie, Jurquet, Anne-laure, Juven, Aurélien, Kamal, Maud, Kantapareddy, Pascal, Kaphan, Elsa, Karayan-Tapon, Lucie, Kasper, Edwige, Kerbellec, Lara, Keren, Boris, Khalifa, Emmanuel, Van Kien, Philippe Khau, Kheddouci, Sihem, Kientz, Caroline, Kim, Rathana, Knapke, Antjie, Koenig, Michel, isabelle Kone, Konyukh, Marina, Kormann, Raphaël, Kossorotoff, Manoelle, Kuentz, Paul, Kyndt, Florence, L'Haridon, Anaïs, Labrune, Philippe, Lackmy, Marilyn, Lacombe, Didier, Lacroix, Ludovic, Laffargue, Fanny, Lahlou, Ghizlene, Laizet, Yec'han, Lambert, Laetitia, Lamoril, Jérôme, Lamouroux, Audrey, Landais, Emilie, Landman, Samuel, Landry, Elise, Lapillonne, Hélène, Lapointe, Anne-Sophie, Larcher, Lise, Lardeux, Pierre, Largeaud, Laetitia, Larger, Etienne, Larrouquere, Louis, Lasolle, Hélène, Lasseaux, Eulalie, Latypova, Xenia, Laurens, Tiphany, Laurent, Camille, Laurent-Puig, Pierre, Lautrette, Géraldine, Lauvray, Thomas, Lavallart, Benoît, Lavenu-Bombled, Cécile, Laverdure, Noémie, Le Bris, Yannick, Le Chalony, Catherine, Le Du, Nathalie, Le Folgoc, Gaëlle, Le Gac, Gerald, Le Gall, Jessica, Le Guillou, Edouard, Le Guillou, Xavier, Le Guyader, Gwenaël, Le Ray, Maryannick, Le Saux, Olivia, Le Tourneau, Christophe, Lebecque, Benjamin, Lebellec, Loïc, Lebigot, Elise, Leblond, Pierre, Leboulanger, Nicolas, Lebras, Laure, Lebre, Anne-Sophie, Lebreton, Louis, Lecoquierre, François, Lefebvre, Mathilde, Legendre, Marine, Leglise, Camille, Legrand, Clémentine, Lehalle, Daphné, Lejeune, Catherine, Lemaitre, Christine, Leman, Raphaël, Lepage, Mathis, Lermine, Alban, Leroy, Karen, Lesca, Gaëtan, Lesieur-Sebellin, Marion, Letexier, Mélanie, Lethimonnier, Franck, Levaillant, Lucie, Levy, Jonathan, Levy, Yves, Lévy, Pascale, Lhermitte, Ludovic, Linglart, Agnès, Lionnet, Clément, Livon, Doriane, Lode, Laurence, Lodin, Magalie, Lopez, Jonathan, Lopez, Maureen, Lortholary, Alain, Louha, Malek, Louvrier, Camille, Ludwig, Thomas E., Luvet, Auriane, Lyonnet, Stanislas, Makowski, Caroline, Malan, Valérie, Mallaret, Martial, Mallet, Delphine, Mallet, Stéphanie, Malphettes, Marion, Manaud, Nathalie, Mancini, Pierre, Manfredi, Sylvain, Manouvrier, Sylvie, Mansard, Luke, Mansard, Sandrine, Mansour-Hendili, Lamisse, Mansuy, Ludovic, Maquet, Julien, Marçais, Ambroise, Marceau-Renaut, Alice, Marec-Berard, Perrine, Marelli, Cécilia, Marenne, Gaëlle, Marey, Isabelle, Margier, Jennifer, Margot, Henri, Marie, Guillaume, Marin, Victor, Marisa, Laetitia, Marlin, Sandrine, Marquant, Emeline, Marquet, Valentine, Marsili, Luisa, Martin, Amaury, Martinerie, Laetitia, Maruani, Anna, Marzin, Pauline, Massard, Christophe, Masson, Emmanuelle, Mathieu, Flavie, Mathieu, Marion, Mathoulin-Pelissier, Simone, Matthieu, Flore, Mauras, Mathilde, Maureille, Aurélien, Mazel, Benoit, Mazeres, Mary, Leer, Anne Mc, Melki, Isabelle, Menassa, Rita, Méneret, Aurélie, Menjard, Julie, Mercier, Anne, Merieau, Elodie, Merlin, Marie-Sophie, Merlio, Jean-Philippe, Meslier, Cécile, Mesnard, Laurent, Mestre-Godin, Sandrine, Metay, Corinne, Meunier, Sandrine, Meyer, Pierre, Michaud, Vincent, Michel-Calemard, Laurence, Mignot, Cyril, Miguet, Marguerite, Millat, Gilles, Mirault, Tristan, Miron de l'Espinay, Albane, Molac, Clémence, Molin, Arnaud, Mondet, Julie, Monin, Faustine, Monin, Pauline, Monneur, Audrey, Monnot, Sophie, Montani, David, Morel, Elodie, Morel, Godelieve, Morel, Valérie, Moretta, Jessica, Morice-Picard, Fanny, Morillon, Lucie, Morin, Carole, Morin-Meschin, Marie-Emmanuelle, Morlat, Philippe, Moshous, Despina, Mouret-Fourme, Emmanuelle, Moussy, Alice, Moutton, Sébastien, Mouzat, Kévin, Muletier, Romane, Muller, Jean, Muller, Marie, Nadaj-Pakleza, Aleksandra, Nambot, Sophie, Nathan, Nadia, Nava, Caroline, Nectoux, Juliette, Netter, Jeanne, Neumann, Florent, Neveu, Julien, Nevière, Zoé, Nguyen, Laetitia, Niclass, Tanguy, Nicolas, Gaël, Nicolas, Laury, Ningarhari, Massih, Nogues, Catherine, Novello, Cécile, Nowak, Frédérique, Odent, Sylvie, Odou, Marie-Françoise, Olaso, Robert, Otmani, Sarah, Ovaert, Caroline, Pacot, Laurence, Pages, Mélanie, Paillard, Catherine, Palmyre, Aurélien, Panagiotakaki, Eleni, Pannard, Myriam, Paoletti, Anne, Papadopoulou, Maria T., Papathanasiou, Matthildi, Paquis, Véronique, Parfait, Béatrice, Paris, Camille, Paris, Clara, Paris, Françoise, Pasmant, Eric, Pasquet, Marlène, Passet, Marie, Pastoret, Cédric, Patat, Olivier, Patay, Léa, Paul, Antoine, Pebrel-Richard, Céline, Peduto, Cristina, Peffault de Latour, Regis, Pegat, Antoine, Pelletier, Annick, Pelletier, Valérie, Pellisson, Fanny, Pennamen, Perrine, Pereira, Victor, Pernin-Grandjean, Julie, Péron, Julien, Perrier, Alexandre, Perrier, Lionel, Perrin, Laurence, Perthus, Isabelle, Petit, Arnaud, Petit, Audrey, Petit, Florence, Petit, François, Petrov, Yuliya, Peyre, Hugo, Philippe, Christophe, Piard, Juliette, Pierre-Noël, Elise, Pierron, Gaëlle, Pimouguet, Clément, Pingault, Véronique, Pinson, Stéphane, Pion, Emmanuelle, Plaisancié, Julie, Planes, Marc, Planté-Bordeneuve, Pauline, Plas, William, Plutino, Morgane, Poignie, Ludivine, Poinsignon, Vianney, Poirée, Marilyne, Pons, Nicolas, Pontier, Bénédicte, Porquet-Bordes, Valérie, Porteret, Camille, Potier, Delphine, Potier, Louis, Pouessel, Damien, Poujade, Laura, Preau, Marie, Preudhomme, Claude, Prieur, Fabienne, Probst, Vincent, Procaccio, Vincent, Prot-Bertoye, Caroline, Prunier, Delphine, Puechberty, Jacques, Pujalte, Mathilde, Qebibo, Leila, Quemener-Redon, Sylvia, Quérée, Isabelle, Quijano-Roy, Susana, Quirin, Nicolas, Racine, Caroline, Raimbault, Sandra, Raimbourg, Judith, Rajaoba, Marine, Rambaud, Thomas, Ramirez, Carole, Ramond, Francis, Ranguin, Kara, Rausell, Antonio, Ravel, Jean-Marie, Ravelli, Claudia, Raverot, Gerald, Ray-Coquard, Isabelle, Raynal, Caroline, Réant, Patricia, Rebours, Vinciane, Redon, Richard, Réguerre, Yves, Reix, Philippe, Renard, Cécile, Renaud, Mathilde, Rendu, John, Renoux, Céline, Rey, Romain, Reynaud, Rachel, Rhinan, Lucie, Riant, Florence, Riccardi, Florence, Richard, Pascale, Ricou, Agathe, Rigalleau, Vincent, Rio, Marlène, Rivière, Axelle, Robelin, Patrick, Robert, Marion, Robert, Thomas, Rohmer, Barbara, Romanet, Pauline, Romoli, Arnaud, Rondeau, Sophie, Rooryck, Caroline, Roquelaure, Bertrand, Rosain, Jérémie, Rossi, Massimiliano, Rossignol, Sylvie, Rothenbuhler, Anya, Rouel, Nadège, Rouillon, Marine, Roux, Anne-Francoise, Roux-Buisson, Nathalie, Rouzier, Cécile, Roze, Emmanuel, Ruaud, Lyse, Ruault, Valentin, Ruysschaert, Claire, Saada, Esma, Saadi - Ait El Mkadem, Samira, Saandi, Thoueiba, Sabour, Niki, Sacconi, Sabrina, Saffroy, Raphaël, Safraou, Hana, Saillour, Virginie, Pierre, Aude Saint, Saint-Martin, Cécile, Saintigny, Pierre, Salaun, Gaëlle, Salgado, David, Salle, Laurence, Samuel, Didier, Sanlaville, Damien, Sapey-Triomphe, Laure, Sarnacki, Sabine, Sarrazin, Elisabeth, Sarret, Catherine, Satre, Véronique, Saugier-Veber, Pascale, Saultier, Paul, Saumet, Laure, Schaefer, Elise, Scheyer, Nicolas, Schiff, Isabelle, Schleiermacher, Gudrun, Schleinitz, Nicolas, Schluth-Bolard, Caroline, Schneider, Anouck, Schwartz, Bertrand, Sebaoun, Jean-Marc, Serey-Gaut, Margaux, Serrier, Hassan, Servais, Aude, Serveaux-Dancer, Marine, Sevenet, Nicolas, Seyve, Antoine, Sibony-Cohen, Alicia, Sicre de Fontbrune, Flore, Sigaudy, Sabine, Sigaux, François, Simaga, Fatoumata, Simmet, Victor, Simon, Pauline, Simon, Sophie, Sirveaux, François, Smol, Thomas, Solé, Guilhem, Soler, Gwendoline, Solignac, Pauline, Soriani, Marie-Hélène, Soubeyran, Isabelle, Soulier, Jean, Spelle, Laurent, Sperelakis-Beedham, Brian, Spinazzi, Marco, Spodenkiewicz, Marta, Spraul, Anne, Squiban, Barbara, Srikaran, Arunya, Steffann, Julie, Stetco, Anamaria, Stoeva, Radka, Stojkovic, Tanya, Stoppa-Lyonnet, Dominique, Suarez, Felipe, Sujobert, Pierre, Svahn, Juliette, Ta, Minh-Chau, Tabet, Anne-Claude, Tachon, Gaëlle, Tallegas, Matthias, Tallet, Anne, Tambourin, Pierre-Edmond, Tandonnet, Julie, Tardy, Véronique, Tavernier, Emmanuelle, Tchernitchko, Dimitri, Teillon-Berranger, Marie-Hélène, Tenenbaum, Julie, Teoli, Jordan, Tessarech, Marine, Tessoulin, Benoit, Tharreau, Mylène, Thauvin-Robinet, Christel, Theou-Anton, Nathalie, Thevenon, Julien, Thomas, Anne, Thomas, Laure, Thomas, Quentin, Thomas-Teinturier, Cécile, Tieulie, Nathalie, Tinat, Julie, Tlemsani, Camille, Tondeur, Sylvie, Tosca, Lucie, Tosi, Diego, Tougeron, David, Touraine, Phlippe, Tournier-Lasserve, Elisabeth, Toutain, Annick, Mau-Them, Frédéric Tran, Tranchant, Christine, Trédan, Olivier, Trimouille, Aurélien, Trochu, Jean-Noël, Tronel, Vincent, Trouba, Cécile, Truchetet, Marie-Elise, Truffaux, Nathalène, Tsalamlal, Amel, Turlotte, Edouard, Turon, Violette, Tusseau, Maud, Uhrhammer, Nancy, Vaché, Christel, Valence, Stéphanie, Valentin, Thibaud, Valero, René, Valleix, Sophie, Vallet, Marion, Vanacker, Hélène, Vande-Perre, Pierre, Vandenbrouck, Yves, Vanlerberghe, Clémence, Vargas-Poussou, Rosa, Vatier, Camille, Vauchel, Vincent, Vaur, Dominique, Velo-Suarez, Lourdes, Venat, Laurence, Vera, Gabriella, Verebi, Camille, Verley, Célia, Verlingue, Loïc, Verny, Christophe, Veronese, Lauren, Verotte, Nelly, Verret, Benjamin, Vial, Yoann, Vialard, Francois, Viari, Alain, Vidailhet, Marie, Vidaud, Dominique, Vidaud, Michel, Vignes, Stéphane, Vigouroux, Clothilde, Villard, Laurent, Villeneuve, Laurent, Villié, Patricia, Villy, Marie-Charlotte, Vinauger, Lara, Vinceneux, Armelle, Vincenot, Anne, Vinciguerra, Christine, Vitobello, Antonio, Vourc'h, Patrick, Vozy, Aurore, Vuillaume-Winter, Marie-Laure, Vuillaumier-Barrot, Sandrine, Wahbi, Karim, Wallet, Cédrick, Walter, Thomas, Walther-Louvier, Ulrike, Watson, Sarah, Waymel, Anne-Christine, Weinhard, Sara, Wicker, Camille, Willems, Marjolaine, Wourms, Justine, Wyrebski, Antoine, Yauy, Kévin, Zaidan, Mohamad, Zaloszyc, Ariane, Zattara, Hélène, Zawadzki, Christophe, and Ziegler, Alban

Published
2025
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4. Systematic analysis of SCN5A variants associated with inherited cardiac diseases

Author

Hermida, Alexis, Jedraszak, Guillaume, Ader, Flavie, Denjoy, Isabelle, Fressart, Véronique, Maury, Phillipe, Beyls, Christophe, Bloch, Adrien, Clerici, Gaël, Daire, Elise, Defaye, Pascal, Dupin-Deguine, Delphine, Garçon, Loic, Klug, Didier, Ginglinger, Emmanuelle, Hermida, Jean-Sylvain, Jesel, Laurence, Khraiche, Diala, Kubala, Maciej, Lacotte, Jérôme, Laredo, Mikael, Leenhardt, Antoine, Le Guillou, Xavier, Lesaffre, Francois, Maltret, Alice, Magnin-Poull, Isabelle, Marijon, Eloi, Nambot, Sophie, Neyroud, Nathalie, Ninni, Sandro, Palmyre, Aurélien, Pasquie, Jean Luc, Proukhnitzky, Julie, Reant, Patricia, Richard, Pascale, Rollin, Anne, Rooryck, Caroline, Sacher, Frédéric, Schaefer, Elise, Vernier, Agathe, Winum, Pierre-François, Wahbi, Karim, Waintraub, Xavier, Waldmann, Victor, Weber, Sacha, Zouaghi, Amir, Charron, Philippe, Extramiana, Fabrice, and Gandjbakhch, Estelle

Published
2025
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5. Clinical impact of genetic testing in a large cohort of pediatric cardiomyopathies

Author

Ader, Flavie, Derridj, Neil, Brehin, Anne Claire, Domanski, Olivia, Baudelet, Jean Benoit, Gras, Pauline, Kuster, Alice, Benbrik, Nadir, Troadec, Yann, Denjoy, Isabelle, Bonnefoy, Ronan, Beyler, Constance, El Chehadeh, Salima, Schaeffer, Elise, Dupin-Deguine, Delphine, Bloch, Adrien, Rooryck, Caroline, Proukhnitzky, Julie, Bosser, Gilles, Vincenti, Marie, Gandjbakhch, Estelle, Charron, Philippe, Richard, Pascale, Bonnet, Damien, and Khraiche, Diala

Published
2025
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6. Temporal trends in population characteristics and type of device among primary prevention implantable cardioverter defibrillator recipients: The DAI-PP programme

Author

Frodi, Diana My, Boveda, Serge, Fournier, Victor, Kerkouri, Fawzi, Anselme, Frederic, Deharo, Jean-Claude, Extramiana, Fabrice, Fauchier, Laurent, Gandjbakhch, Estelle, Gras, Daniel, Hermida, Alexis, Jesel-Morel, Laurence, Leclercq, Christophe, Lellouche, Nicolas, Menet, Aymeric, Narayanan, Kumar, Piot, Olivier, Probst, Vincent, Sadoul, Nicolas, Taieb, Jerome, Defaye, Pascal, Marijon, Eloi, and Garcia, Rodrigue

Published
2025
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8. Management of conduction disease and arrhythmias in patients with cardiac amyloidosis: A position paper from the Working Group of Cardiac Pacing and Electrophysiology of the French Society of Cardiology

Author

Lellouche, Nicolas, Defaye, Pascal, Algalarrondo, Vincent, Gandjbakhch, Estelle, Fauchier, Laurent, Champ-Rigot, Laure, Delsarte, Laura, Extramiana, Fabrice, Marijon, Eloi, Martins, Raphael, Probst, Vincent, Garcia, Rodrigue, Combes, Stephane, Taieb, Jerome, Ait Said, Mina, Mette, Carole, Piot, Olivier, Boveda, Serge, Klug, Didier, Guenancia, Charles, Sacher, Frederic, and Maury, Philippe

Published
2025
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9. Abstract 4142400: Clinical implication and potential role of immunosuppression for myocarditis episodes in patients with desmoplakin cardiomyopathy: hope from the DSP-ERADOS Network?

Author

Gasperetti, Alessio, Peretto, Giovanni, Muller, Steven, Laredo, mikael, Carrick, Richard, Asatryan, Babken, Protonotarios, Alexandros, Murray, Brittney, Scheel, Paul, Pilichou, Kalliopi, Syrris, Petros, Jason, Max, Medo, Kristen, Rossi, Valentina, Saguner, Ardan, Hylind, Robyn, Abrams, Dominic, Cadrin-Tourigny, Julia, olivotto, iacopo, Biagini, Elena, Cox, Moniek, CHARRON, Philippe, Ware, James, Cal, Leonardo, smith, eric, Ingles, Jodie, Ader, Flavie, Peters, Stacey, russo, jeremy, Zentner, Dominica, Bahr, Eric, Carruth, Eric, Haggerty, Chris, Parikh, Victoria, Taylor, Matthew, Mestroni, Luisa, Sinagra, Gianfranco, Wilde, Arthur, Gandjbakhch, Estelle, Te Riele, Anneline, Van Tintelen, Peter, Elliott, Perry, Adamo, Luigi, James, Cynthia, Merlo, Marco, Lakdawala, Neal, Bauce, Barbara, Helms, Adam, Calkins, Hugh, and Gilotra, Nisha

Published
2024
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10. Distinct Substrates of Idiopathic Ventricular Fibrillation Revealed by Arrhythmia Characteristics on Implantable Cardioverter-Defibrillator

Author

Haïssaguerre, Michel, Sellal, Jean-Marc, Benali, Karim, de Becker, Benjamin, Defaye, Pascal, Pascale, Patrizio, Martins, Raphael, Mabo, Philippe, Xhaet, Olivier, Extramiana, Fabrice, Surget, Elodie, Lavergne, Thomas, Marijon, Eloi, Adragao, Pedro, Carvalho, Maria Salomé, Milliez, Paul-Ursmar, Laredo, Mickael, Gandjbakhch, Estelle, Giustetto, Carla, Gaita, Fiorenzo, Tilz, Roland, Jesel-Morel, Laurence, Steinfurt, Johannes, Arentz, Thomas, Knecht, Sebastien, Duytschaever, Mattias, Roten, Laurent, Reichlin, Tobias, Fatemi, Marjaneh, Mansourati, Jacques, Kouakam, Claude, Bessière, Francis, Chevalier, Philippe, Tadros, Rafik, Macle, Laurent, Gallego, Francisco, Hadjis, Alexios, Sacher, Frederic, Pereira, Dylan, Hourdain, Jerome, Deharo, Jean-Claude, Eschalier, Romain, Massoulié, Grégoire, Maury, Philippe, Latcu, Decebal Gabriel, Anselme, Frederic, Duchateau, Josselin, Tixier, Romain, Nademanee, Koonlawee, Nogami, Akihiko, de Groot, Natasja, Vigmond, Edward, Bernus, Olivier, Strik, Marc, Bordachar, Pierre, Cathala, Aude, Bouteiller, Xavier, Dubois, Remi, and Ploux, Sylvain

Published
2024
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11. Mode and Characteristics of Arrhythmia Initiation in Idiopathic Ventricular Fibrillation: A THESIS Substudy

Author

Asatryan, Babken, Baskar, Shankar, Berne, Paola, Blommaert, Dominique, Dormal, Fabien, Boccellino, Antonio, Ciconte, Giuseppe, Giustetto, Carla, Haqqani, Harris, Jackson, Liang J., DG, Latcu, Lellouche, Nicolas, Marai, Ibrahim, Nakahara, Shiro, Pannone, Luigi, de Asmundis, Carlo, Pavri, Behzad B., Porretta, Alessandra Pia, Pruvot, Etienne, Rosu, Radu, Scherr, Daniel, Steinfurt, Johannes, Yagishita, Atsuhiko, Belhassen, Bernard, Conte, Giulio, Steinberg, Christian, Whitaker, John, Khan, Habib R., Laredo, Mikael, Doldi, Florian, Ho, Reginald, Tadros, Rafik, Dinov, Boris, Chorin, Ehud, Hansom, Simon, Waintraub, Xavier, Eckardt, Lars, Jankelson, Lior, Peichl, Petr, Mellor, Greg, Sy, Raymond W., Rattanawong, Pattara, Stojkovic, Stefan, Garber, Leonid, Suna, Gonca, Kautzner, Josef, Chan, Kim Hoe, Srivathsan, Komandoor, Tedrow, Usha, Havranek, Stepan, Murgatroyd, Francis, Shauer, Ayelet, Winkel, Bo Gregers, Page, Stephen P., Milman, Anat, Lador, Adi, Ayou, Romeo, Sellal, Jean Marc, Chevalier, Philippe, García-Fernández, F. Javier, Reichlin, Tobias, Shah, Dipen, Nazer, Babak, Bermudez-Jimenez, Francisco, Nagase, Satoshi, Morita, Hiroshi, Nam, Gi-Byoung, Pappone, Carlo, Lambiase, Pier D., Strohmer, Bernhard, Stuehlinger, Markus, Gandjbakhch, Estelle, Schulze-Bahr, Eric, Krahn, Andrew D., and Tovia-Brodie, Oholi

Published
2024
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12. Systematic analysis of drug-associated myocarditis reported in the World Health Organization pharmacovigilance database.

Author

Nguyen, Lee, Cooper, Leslie, Kerneis, Mathieu, Funck-Brentano, Christian, Silvain, Johanne, Brechot, Nicolas, Hekimian, Guillaume, Ammirati, Enrico, Ben MBarek, Badr, Redheuil, Alban, Gandjbakhch, Estelle, Bihan, Kevin, Lebrun-Vignes, Bénédicte, Ederhy, Stephane, Dolladille, Charles, Moslehi, Javid, and Salem, Joe-Elie

Subjects
Adverse Drug Reaction Reporting Systems, Antineoplastic Agents, Antipsychotic Agents, Bayes Theorem, Cross-Sectional Studies, Data Management, Databases, Factual, Humans, Immunotherapy, Myocarditis, Pharmaceutical Preparations, Pharmacovigilance, Systems Analysis, World Health Organization
Abstract

While multiple pharmacological drugs have been associated with myocarditis, temporal trends and overall mortality have not been reported. Here we report the spectrum and main features of 5108 reports of drug-induced myocarditis, in a worldwide pharmacovigilance analysis, comprising more than 21 million individual-case-safety reports from 1967 to 2020. Significant association between myocarditis and a suspected drug is assessed using disproportionality analyses, which use Bayesian information component estimates. Overall, we identify 62 drugs associated with myocarditis, 41 of which are categorized into 5 main pharmacological classes: antipsychotics (n = 3108 reports), salicylates (n = 340), antineoplastic-cytotoxics (n = 190), antineoplastic-immunotherapies (n = 538), and vaccines (n = 790). Thirty-eight (61.3%) drugs were not previously reported associated with myocarditis. Antipsychotic was the first (1979) and most reported class (n = 3018). In 2019, the two most reported classes were antipsychotics (54.7%) and immunotherapies (29.5%). Time-to-onset between treatment start and myocarditis is 15 [interquartile range: 10; 23] days. Subsequent mortality is 10.3% and differs between drug classes with immunotherapies the highest, 32.5% and salicylates the lowest, 2.6%. These elements highlight the diversity of presentations of myocarditis depending on drug class, and show the emerging role of antineoplastic drugs in the field of drug-induced myocarditis.

Published
2022

14. Long-Term Arrhythmic Follow-Up and Risk Stratification of Patients With Desmoplakin-Associated Arrhythmogenic Right Ventricular Cardiomyopathy

Author

Gasperetti, Alessio, Carrick, Richard, Protonotarios, Alexandros, Laredo, Mikael, van der Schaaf, Iris, Syrris, Petros, Murray, Brittney, Tichnell, Crystal, Cappelletto, Chiara, Gigli, Marta, Medo, Kristen, Crabtree, Peter, Saguner, Ardan M., Duru, Firat, Hylind, Robyn, Abrams, Dominic, Lakdawala, Neal K., Massie, Charles, Cadrin-Tourigny, Julia, Targetti, Mattia, Olivotto, Iacopo, Graziosi, Maddalena, Cox, Moniek, Biagini, Elena, Charron, Philippe, Casella, Michela, Tondo, Claudio, Yazdani, Momina, Ware, James S., Prasad, Sanjay, Calò, Leonardo, Smith, Eric, Helms, Adam, Hespe, Sophie, Ingles, Jodie, Tandri, Harikrishna, Ader, Flavie, Mestroni, Luisa, Wilde, Arthur, Merlo, Marco, Gandjbakhch, Estelle, Calkins, Hugh, te Riele, Anneline S.J.M., Peter van Tintelen, J., Elliot, Perry, and James, Cynthia A.

Published
2024
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16. Position paper on sustainability in cardiac pacing and electrophysiology from the Working Group of Cardiac Pacing and Electrophysiology of the French Society of Cardiology

Author

Sacher, Frédéric, Bacquelin, Raoul, Bessiere, Francis, Ditac, Geoffroy, Duchateau, Josselin, Ait-Said, Mina, Boveda, Serge, Extramiana, Fabrice, Delsarte, Laura, Fauchier, Laurent, Gandjbakhch, Estelle, Garcia, Rodrigue, Klug, Didier, Lellouche, Nicolas, Marijon, Eloi, Martins, Raphael, Maury, Philipe, Mette, Carole, Piot, Olivier, Taieb, Jerome, and Defaye, Pascal

Published
2024
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17. Proposed diagnostic criteria for arrhythmogenic cardiomyopathy: European Task Force consensus report

Author

Corrado, Domenico, Anastasakis, Aris, Basso, Cristina, Bauce, Barbara, Blomström-Lundqvist, Carina, Bucciarelli-Ducci, Chiara, Cipriani, Alberto, De Asmundis, Carlo, Gandjbakhch, Estelle, Jiménez-Jáimez, Juan, Kharlap, Maria, McKenna, William J, Monserrat, Lorenzo, Moon, James, Pantazis, Antonis, Pelliccia, Antonio, Perazzolo Marra, Martina, Pillichou, Kalliopi, Schulz-Menger, Jeanette, Jurcut, Ruxandra, Seferovic, Petar, Sharma, Sanjay, Tfelt-Hansen, Jacob, Thiene, Gaetano, Wichter, Thomas, Wilde, Arthur, and Zorzi, Alessandro

Published
2024
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18. Rationale and design of the ARAMIS trial: Anakinra versus placebo, a double blind randomized controlled trial for the treatment of acute myocarditis

Author

Kerneis, Mathieu, Cohen, Fleur, Combes, Alain, Amoura, Zahir, Pare, Carine, Brugier, Delphine, Puymirat, Etienne, Abtan, Jeremie, Lattuca, Benoit, Dillinger, Jean-Guillaume, Hauguel-Moreau, Marie, Silvain, Johanne, Salem, Joe-Elie, Gandjbakhch, Estelle, Hekimian, Guillaume, Redheuil, Alban, Vicaut, Eric, and Montalescot, Gilles

Published
2023
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20. Rapid ventricular tachycardia in patients with tetralogy of Fallot and implantable cardioverter-defibrillator: Insights from the DAI-T4F nationwide registry

Author

Laredo, Mikael, Duthoit, Guillaume, Sacher, Frédéric, Anselme, Frédéric, Audinet, Caroline, Bessière, Francis, Bordachar, Pierre, Bouzeman, Abdeslam, Boveda, Serge, Bun, Sok Sithikun, Chassignolle, Morgane, Clerici, Gaël, Da Costa, Antoine, de Guillebon, Maxime, Defaye, Pascal, Elbaz, Nathalie, Eschalier, Romain, Extramiana, Fabrice, Fauchier, Laurent, Hermida, Alexis, Gandjbakhch, Estelle, Garcia, Rodrigue, Gourraud, Jean-Baptiste, Guenancia, Charles, Guy-Moyat, Benoit, Irles, Didier, Iserin, Laurence, Jourda, François, Koutbi, Linda, Labombarda, Fabien, Ladouceur, Magalie, Lagrange, Philippe, Lellouche, Nicolas, Mansourati, Jacques, Marquié, Christelle, Martins, Raphael, Massoulié, Grégoire, Mathiron, Amel, Maury, Philippe, Messali, Anne, Milhem, Antoine, Mondoly, Pierre, Nguyen, Cédric, Ninni, Sandro, Pasquié, Jean Luc, Pierre, Bertrand, Pujadas, Penelope, Sellal, Jean-Marc, Thambo, Jean-Benoit, Walton, Camille, Winum, Pierre, Zakine, Cyril, Zhao, Alexandre, Jouven, Xavier, Combes, Nicolas, Marijon, Eloi, and Waldmann, Victor

Published
2023
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22. Androgenic Effects on Ventricular Repolarization: A Translational Study From the International Pharmacovigilance Database to iPSC-Cardiomyocytes.

Author

Salem, Joe-Elie, Yang, Tao, Moslehi, Javid, Waintraub, Xavier, Gandjbakhch, Estelle, Bachelot, Anne, Hidden-Lucet, Francoise, Hulot, Jean-Sebastien, Knollmann, Bjorn, Lebrun-Vignes, Benedicte, Funck-Brentano, Christian, Glazer, Andrew, and Roden, Dan

Subjects
androgen antagonists, hypogonadism, long QT syndrome, testosterone, torsades de pointes, Androgens, Antineoplastic Agents, Benzamides, Cell Differentiation, Cells, Cultured, Databases, Factual, Humans, Hypogonadism, Induced Pluripotent Stem Cells, International Cooperation, Long QT Syndrome, Male, Myocytes, Cardiac, Nitriles, Pharmacovigilance, Phenylthiohydantoin, Risk, Torsades de Pointes, Translational Research, Biomedical
Abstract

BACKGROUND: Male hypogonadism, arising from a range of etiologies including androgen-deprivation therapies (ADTs), has been reported as a risk factor for acquired long-QT syndrome (aLQTS) and torsades de pointes (TdP). A full description of the clinical features of aLQTS associated with ADT and of underlying mechanisms is lacking. METHODS: We searched the international pharmacovigilance database VigiBase for men (n=6 560 565 individual case safety reports) presenting with aLQTS, TdP, or sudden death associated with ADT. In cardiomyocytes derived from induced pluripotent stem cells from men, we studied electrophysiological effects of ADT and dihydrotestosterone. RESULTS: Among subjects receiving ADT in VigiBase, we identified 184 cases of aLQTS (n=168) and/or TdP (n=68; 11% fatal), and 99 with sudden death. Of the 10 ADT drugs examined, 7 had a disproportional association (reporting odds ratio=1.4-4.7; P

Published
2019

23. Sex Differences in Outcomes of Tetralogy of Fallot Patients With Implantable Cardioverter-Defibrillators

Author

Akret, Chrystelle, Albenque, Jean-Paul, Algalarrondo, Vincent, Alonso, Christine, Amet, Denis, Ansselme, Frédéric, Asselin, Anouk, Audinet, Caroline, Badenco, Nicolas, Bader, Hugues, Badoz, Marc, Baudinaud, Pierre, Behar, Nathalie, Ben Kilani, Mouna, Bernard, Yvette, Bertaux, Géraldine, Bertrand, Cathy, Bessiere, Francis, Blangy, Hughes, Bonnet, Damien, Bordchar, Pierre, Bouzeman, Abdeslam, Boveda, Serge, Bru, Paul, Bun, Sok Sithikun, Carabelli, Adrien, Cardin, Christèle, Cauchemez, Bruno, Chalbia, Tej, Champ-Rigot, Laure, Chastre, Thomas, Chevallier, Philippe, Clementy, Nicolas, Clerici, Gaël, Combes, Nicolas, Combes, Stéphane, Da Costa, Antoine, De Chillou, Christian, De Guillebon, Maxime, Defaye, Pascal, Degand, Bruno, Deharo, Jean-Claude, Derval, Nicolas, Di Filippo, Sylvie, Domain, Guillaume, Dompnier, Antoine, Dulac, Arnaud, Duparc, Alexandre, Duplantier, D Cécile, Duthoit, Guillaume, El Bouazzaoui, Rim, Elbaz, Nathalie, Enache, Bogdan, Eschalier, Romain, Extramiana, Fabrice, Fauchier, Laurent, Fiorello, Pierre, Frey, Pierre, Freysz, Luc, Galand, Vincent, Gandjbakhch, Estelle, Garcia, Rodrigue, Gardey, Kevin, Geoffroy, Olivier, Godin, Bénédicte, Gourraud, Jean-Baptiste, Goussot, Samuel, Grimard, Caroline, Guenancia, Charles, Guichard, Jean-Baptiste, Guy-Moyat, Benoit, Haissaguerre, Michel, Halimi, Franck, Hamon, David, Hascoet, Sébastien, Hasni, Karim, Hermida, Alexis, Hermida, Jean-Sylvain, Hidden-Lucet, Françoise, Hocini, Mélèze, Hourdain, Jérome, Irles, Didier, Iserin, Laurence, Jacon, Peggy, Jauvert, Gaël, Jean, Frédéric, Johnson, Nicolas, Jourda, François, Khattar, Pierre, Khoueiry, Ziad, Koutbi, Rita, Labombarda, Fabien, Laborie, Guillaume, Lactu, Gabriel, Ladouceur, Magalie, Lagrange, Philippe, Lallemand, Pierre-Marc, Laredo, Mikael, Laurent, Gabriel, Lavergne, Thomas, Lazarus, Arnaud, Le Gloan, Laurianne, Leclercq, Christophe, Leenhardt, Antoine, Lellouche, Nicolas, Loose, Christophe, Mabo, Philippe, Maltret, Alice, Mandel, Franck, Mansourati, Jacques, Marijon, Eloi, Marquie, Christelle, Martins, Raphaël, Mathiron, Amel, Maupain, Carole, Maury, Philippe, Messali, Anne, Milhelm, Antoine, Milliez, Paul, Mirolo, Adrian, Mondoly, Pierre, Moubarak, Ghassan, Mourot, Stéphane, Nguyen, Cédric, Ollitrault, Jacky, Ollitrault, Pierre, Otmani, Akli, Pasquie, Jean-Luc, Pavin, Dominique, Perier, Marie-Cécile, Philibert, Séverinne, Poindron, Damien, Potelle, Charlotte, Probst, Vincent, Puie, Paul, Pujadas, Penelope, Rollin, Anne, Romeyer-Bouchard, Cécile, Sacher, Frédéric, Sadoul, Nicolas, Sagnard, Audrey, Sagnol, Pascal, Savoure, Arnaud, Scarlatti, Didier, Sellal, Jean Marc, Sharifzadehgan, Ardalan, Squara, Fabien, Tanese, Nikita, Thambo, Jean Benoit, Thomas, Olivier, Varlet, Emie, Venier, Sandrine, Stephanopoli, Quentin Voglimacci, Waintraub, Xavier, Waldmann, Victor, Walton, Camille, Wiart, Françoise, Winum, Pierre, Zakine, Cyril, Zhao, Alexandre, Zouaghi, Amir, Koutbi, Linda, Bessière, Francis, Marquié, Christelle, Bordachar, Pierre, Al Arnaout, Alain, Anselme, Frédéric, Chassignolle, Morgane, de Guillebon, Maxime, Massoulié, Grégoire, Narayanan, Kumar, Ninni, Sandro, Pierre, Bertrand, Pasquié, Jean-Luc, Thambo, Jean-Benoit, and Jouven, Xavier

Published
2022
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24. Malignant Purkinje ectopy induced by sodium channel blockers

Author

Escande, William, Gourraud, Jean-Baptiste, Haissaguerre, Michel, Gandjbakhch, Estelle, Lavergne, Thomas, Martins, Raphael, Cheniti, Ghassen, Krisai, Philipp, Hermida, Jean Sylvain, Maury, Philippe, Merino, Jose-Louis, Pasquié, Jean-Luc, Combes, Nicolas, Surget, Elodie, Duchateau, Josselin, Pambrun, Thomas, Derval, Nicolas, Hocini, Mélèze, Jaïs, Pierre, Postema, Pieter G., Nademanee, Koonlawee, Vigmond, Ed, Bernus, Olivier, Sacher, Frederic, and Probst, Vincent

Published
2022
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25. Lack of early etiologic investigations in young sudden cardiac death

Author

Sharifzadehgan, Ardalan, Gaye, Bamba, Bougouin, Wulfran, Narayanan, Kumar, Dumas, Florence, Karam, Nicole, Rischard, Julien, Plu, Isabelle, Waldmann, Victor, Algalarrondo, Vincent, Gandjbakhch, Estelle, Bruneval, Patrick, Beganton, Frankie, Alonso, Christine, Moubarak, Ghassan, Piot, Olivier, Lamhaut, Lionel, Jost, Daniel, Sideris, Georgios, Mansencal, Nicolas, Deye, Nicolas, Voicu, Sebastian, Megarbane, Bruno, Geri, Guillaume, Vieillard-Baron, Antoine, Lellouche, Nicolas, Extramiana, Fabrice, Wahbi, Karim, Varenne, Olivier, Cariou, Alain, Jouven, Xavier, and Marijon, Eloi

Published
2022
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28. Sex differences in the origin of Purkinje ectopy-initiated idiopathic ventricular fibrillation

Author

Surget, Elodie, Cheniti, Ghassen, Ramirez, F. Daniel, Leenhardt, Antoine, Nogami, Akihiko, Gandjbakhch, Estelle, Extramiana, Fabrice, Hidden-Lucet, Françoise, Pillois, Xavier, Benoist, David, Krisai, Philipp, Nakatani, Yosuke, Nakashima, Takashi, Takagi, Takamitsu, Kamakura, Tsukasa, André, Clémentine, Welte, Nicolas, Chauvel, Rémi, Tixier, Romain, Duchateau, Josselin, Pambrun, Thomas, Derval, Nicolas, Jaïs, Pierre, Sacher, Frédéric, Bernus, Olivier, Hocini, Mélèze, and Haïssaguerre, Michel

Published
2021
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29. Arrhythmia-induced cardiomyopathy: A potentially reversible cause of refractory cardiogenic shock requiring venoarterial extracorporeal membrane oxygenation

Author

Hékimian, Guillaume, Paulo, Nicolas, Waintraub, Xavier, Bréchot, Nicolas, Schmidt, Matthieu, Lebreton, Guillaume, Pineton de Chambrun, Marc, Muller, Grégoire, Franchineau, Guillaume, Bourcier, Simon, Nieszkowska, Ania, Masi, Paul, Leprince, Pascal, Combes, Alain, Gandjbakhch, Estelle, and Luyt, Charles-Edouard

Published
2021
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33. Prognostic value of ventricular arrhythmia in early post-infarction left ventricular dysfunction: the French nationwide WICD-MI study.

Author

Echivard, Mathieu, Sellal, Jean-Marc, Ziliox, Chloé, Marijon, Eloi, Bordachar, Pierre, Ploux, Sylvain, Benali, Karim, Marquié, Christelle, Docq, Clémence, Klug, Didier, Eschalier, Romain, Maille, Baptiste, Deharo, Jean-Claude, Babuty, Dominique, Genet, Thibaud, Gandjbakhch, Estelle, Costa, Antoine Da, Piot, Olivier, Minois, Damien, and Gourraud, Jean-Baptiste

Subjects
MYOCARDIAL infarction, VENTRICULAR fibrillation, VENTRICULAR arrhythmia, LEFT ventricular dysfunction, CARDIAC arrest
Abstract

Background and Aims Prophylactic implantable cardioverter–defibrillators (ICDs) are not recommended until left ventricular ejection fraction (LVEF) has been reassessed 40 to 90 days after an acute myocardial infarction. In the current therapeutic era, the prognosis of sustained ventricular arrhythmias (VAs) occurring during this early post-infarction phase (i.e. within 3 months of hospital discharge) has not yet been specifically evaluated in post-myocardial infarction patients with impaired LVEF. Such was the aim of this retrospective study. Methods Data analysis was based on a nationwide registry of 1032 consecutive patients with LVEF ≤ 35% after acute myocardial infarction who were implanted with an ICD after being prescribed a wearable cardioverter–defibrillator (WCD) for a period of 3 months upon discharge from hospital after the index infarction. Results ICDs were implanted either because a sustained VA occurred while on WCD (VA+/WCD, n = 72) or because LVEF remained ≤35% at the end of the early post-infarction phase (VA−/WCD, n = 960). The median follow-up was 30.9 months. Sustained VAs occurred within 1 year after ICD implantation in 22.2% and 3.5% of VA+/WCD and VA−/WCD patients, respectively (P <.0001). The adjusted multivariable analysis showed that sustained VAs while on WCD independently predicted recurrence of sustained VAs at 1 year (adjusted hazard ratio [HR] 6.91; 95% confidence interval [CI] 3.73–12.81; P <.0001) and at the end of follow-up (adjusted HR 3.86; 95% CI 2.37–6.30; P <.0001) as well as 1-year mortality (adjusted HR 2.86; 95% CI 1.28–6.39; P =.012). Conclusions In patients with LVEF ≤ 35%, sustained VA during the early post-infarction phase is predictive of recurrent sustained VAs and 1-year mortality. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Position paper concerning the competence, performance and environment required for the practice of ablation in children and in congenital heart disease

Author

Maury, Philippe, Thambo, Jean Benoit, Maltret, Alice, Combes, Nicolas, Hascoet, Sébastien, Derval, Nicolas, Ladouceur, Magalie, Acar, Philippe, Amedro, Pascal, Anselm, Frederic, Bajolle, Fanny, Basquin, Adeline, Belli, Emre, Bordachar, Pierre, Duthoit, Guillaume, Di Filippo, Sylvie, Fauchier, Laurent, Gandjbakhch, Estelle, Gras, Daniel, Gronier, Celine, Karsenty, Clement, Klug, Didier, Koutbi, Linda, Lacotte, Jérôme, Laurent, Gabriel, Laux, Daniela, Mansourati, Jacques, Marijon, Eloi, Ovaert, Caroline, Sacher, Frederic, Sadoul, Nicolas, Taieb, Jérôme, Waldmann, Victor, Warinfresse, Karine, Defaye, Pascal, Piot, Olivier, and Boveda, Serge

Published
2020
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35. Joint Position Paper of the Working Group of Pacing and Electrophysiology of the French Society of Cardiology and the French Society of Diagnostic and Interventional Cardiac and Vascular Imaging on magnetic resonance imaging in patients with cardiac electronic implantable devices

Author

Gandjbakhch, Estelle, Dacher, Jean-Nicolas, Taieb, Jerome, Chauvin, Michel, Anselme, Frederic, Bartoli, Axel, Boyer, Louis, Cassagnes, Lucie, Cochet, Hubert, Defaye, Pascal, Deharo, Jean-Claude, Dubourg, Benjamin, Fauchier, Laurent, Gras, Daniel, Klug, Didier, Laurent, Gabriel, Mansourati, Jacques, Marijon, Eloi, Maury, Philippe, Piot, Olivier, Pontana, François, Sacher, Frederic, Sadoul, Nicolas, Jacquier, Alexis, and Boveda, Serge

Published
2020
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36. Mode and Characteristics of Arrhythmia Initiation in Idiopathic Ventricular Fibrillation

Author

Belhassen, Bernard, primary, Conte, Giulio, additional, Steinberg, Christian, additional, Whitaker, John, additional, Khan, Habib R., additional, Laredo, Mikael, additional, Doldi, Florian, additional, Ho, Reginald, additional, Tadros, Rafik, additional, Dinov, Boris, additional, Chorin, Ehud, additional, Hansom, Simon, additional, Waintraub, Xavier, additional, Eckardt, Lars, additional, Jankelson, Lior, additional, Peichl, Petr, additional, Mellor, Greg, additional, Sy, Raymond W., additional, Rattanawong, Pattara, additional, Stojkovic, Stefan, additional, Garber, Leonid, additional, Suna, Gonca, additional, Kautzner, Josef, additional, Chan, Kim Hoe, additional, Srivathsan, Komandoor, additional, Tedrow, Usha, additional, Havranek, Stepan, additional, Murgatroyd, Francis, additional, Shauer, Ayelet, additional, Winkel, Bo Gregers, additional, Page, Stephen P., additional, Milman, Anat, additional, Lador, Adi, additional, Ayou, Romeo, additional, Sellal, Jean Marc, additional, Chevalier, Philippe, additional, García-Fernández, F. Javier, additional, Reichlin, Tobias, additional, Shah, Dipen, additional, Nazer, Babak, additional, Bermudez-Jimenez, Francisco, additional, Nagase, Satoshi, additional, Morita, Hiroshi, additional, Nam, Gi-Byoung, additional, Pappone, Carlo, additional, Lambiase, Pier D., additional, Strohmer, Bernhard, additional, Stuehlinger, Markus, additional, Gandjbakhch, Estelle, additional, Schulze-Bahr, Eric, additional, Krahn, Andrew D., additional, Tovia-Brodie, Oholi, additional, Asatryan, Babken, additional, Baskar, Shankar, additional, Berne, Paola, additional, Blommaert, Dominique, additional, Dormal, Fabien, additional, Boccellino, Antonio, additional, Ciconte, Giuseppe, additional, Giustetto, Carla, additional, Haqqani, Harris, additional, Jackson, Liang J., additional, DG, Latcu, additional, Lellouche, Nicolas, additional, Marai, Ibrahim, additional, Nakahara, Shiro, additional, Pannone, Luigi, additional, de Asmundis, Carlo, additional, Pavri, Behzad B., additional, Porretta, Alessandra Pia, additional, Pruvot, Etienne, additional, Rosu, Radu, additional, Scherr, Daniel, additional, Steinfurt, Johannes, additional, and Yagishita, Atsuhiko, additional

Published
2024
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37. Clinical differences between drug‐induced type 1 Brugada pattern and syndrome

Author

Sabbag, Avi, primary, Amoroso, Gisella, additional, Tomer, Orr, additional, Conte, Giulio, additional, Beinart, Roy, additional, Nof, Eyal, additional, Özkartal, Tardu, additional, Ollitrault, Pierre, additional, Laredo, Mikael, additional, Tovia‐Brodie, Oholi, additional, Gandjbakhch, Estelle, additional, de Benedictis, Michele, additional, ter Bekke, Rachel M. A., additional, and Milman, Anat, additional

Published
2024
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38. Clinical impact of post-mortem genetic testing in cardiac death and cardiomyopathy

Author

Marey Isabelle, Fressart Véronique, Rambaud Caroline, Fornes Paul, Martin Laurent, Grotto Sarah, Alembik Yves, Gorka Hervé, Millat Gilles, Gandjbakhch Estelle, Bordet Céline, Grandmaison Geoffroy Lorin de la, Richard Pascale, and Charron Philippe

Subjects
sudden death, cardiac death, cardiomyopathy, post-mortem, genetic testing, Medicine
Abstract

Post-mortem genetic analyses may help to elucidate the cause of cardiac death. The added value is however unclear when a cardiac disease is already suspected or affirmed. Our aim was to study the feasibility and medical impact of post-mortem genetic analyses in suspected cardiomyopathy. We studied 35 patients with cardiac death and suspected cardiomyopathy based on autopsy or clinical data. After targeted sequencing, we identified 15 causal variants in 15 patients (yield 43%) in sarcomeric (n = 8), desmosomal (n = 3), lamin A/C (n = 3) and transthyretin (n = 1) genes. The results had various impacts on families, i.e. allowed predictive genetic testing in relatives (15 families), planned early therapeutics based on the specific underlying gene (5 families), rectified the suspected cardiomyopathy subtype (2 families), assessed the genetic origin of cardiomyopathy that usually has an acquired cause (1 family), assessed the diagnosis in a patient with uncertain borderline cardiomyopathy (1 family), reassured the siblings because of a de novo mutation (2 families) and allowed prenatal testing (1 family). Our findings suggest that post-mortem molecular testing should be included in the strategy of family care after cardiac death and suspected cardiomyopathy, since genetic findings provide additional information useful for relatives, which are beyond conventional autopsy.

Published
2020
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40. Low rates of immediate coronary angiography among young adults resuscitated from sudden cardiac arrest

Author

Waldmann, Victor, Karam, Nicole, Rischard, Julien, Bougouin, Wulfran, Sharifzadehgan, Ardalan, Dumas, Florence, Narayanan, Kumar, Sideris, Georgios, Voicu, Sebastian, Gandjbakhch, Estelle, Jost, Daniel, Lamhaut, Lionel, Ludes, Bertrand, Plu, Isabelle, Beganton, Frankie, Wahbi, Karim, Varenne, Olivier, Megarbane, Bruno, Algalarrondo, Vincent, Extramiana, Fabrice, Lellouche, Nicolas, Celermajer, David S., Spaulding, Christian, Lafont, Antoine, Cariou, Alain, Jouven, Xavier, and Marijon, Eloi

Published
2020
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42. Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study

Author

Ekanem, Emmanuel, Neuzil, Petr, Reichlin, Tobias, Kautzner, Joseph, van der Voort, Pepijn, Jais, Pierre, Chierchia, Gian Battista, Bulava, Alan, Blaauw, Yuri, Skala, Tomas, Fiala, Martin, Duytschaever, Mattias, Szeplaki, Gabor, Schmidt, Boris, Massoullie, Grégoire, Neven, Kars, Thomas, Olivier, Vijgen, Johan, Gandjbakhch, Estelle, Scherr, Daniel, Johannessen, Arne, Keane, David, Boveda, Serge, Maury, Philippe, García-Bolao, Ignacio, Anic, Ante, Hansen, Peter Steen, Raczka, Franck, Lepillier, Antoine, Guyomar, Yves, Gupta, Dhiraj, Van Opstal, Jurren, Defaye, Pascal, Sticherling, Christian, Sommer, Philipp, Kucera, Pavel, Osca, Joaquin, Tabrizi, Fariborz, Roux, Antoine, Gramlich, Michael, Bianchi, Stefano, Adragão, Pedro, Solimene, Francesco, Tondo, Claudio, Russo, Antonio Dello, Schreieck, Jürgen, Luik, Armin, Rana, Obaida, Frommeyer, Gerrit, Anselme, Frédéric, Kreis, Ingo, Rosso, Raphael, Metzner, Andreas, Geller, Laszlo, Baldinger, Samuel H., Ferrero, Angel, Willems, Stephan, Goette, Andreas, Mellor, Greg, Mathew, Shibu, Szumowski, Lukasz, Tilz, Roland, Iacopino, Saverio, Jacobsen, Peter Karl, George, Andrikopoulos, Osmancik, Pavel, Spitzer, Stefan, Balasubramaniam, Richard, Parwani, Abdul Shokor, Deneke, Thomas, Glowniak, Andrzej, Rossillo, Antonio, Pürerfellner, Helmut, Duncker, David, Reil, Peter, Arentz, Thomas, Steven, Daniel, Olalla, Juan José, de Jong, Jonas S.S.G., Wakili, Reza, Abbey, Selim, Timo, Gottschling, Asso, Antonio, Wong, Tom, Pierre, Bertrand, Ewertsen, Niels Christian, Bergau, Leonard, Lozano-Granero, Cristina, Rivero, Maximo, Breitenstein, Alexander, Inkovaara, Jaakko, Fareh, Samir, Latcu, Decebal Gabriel, Linz, Dominik, Müller, Patrick, Ramos-Maqueda, Javier, Beiert, Thomas, Themistoclakis, Sakis, Meininghaus, Dirk Grosse, Stix, Günter, Tzeis, Stylianos, Baran, Jakub, Almroth, Henrik, Munoz, Daniel Rodriguez, de Sousa, João, Efremidis, Michalis, Balsam, Pawel, Petru, Jan, Küffer, Thomas, Peichl, Petr, Dekker, Lukas, Della Rocca, Domenico G., Moravec, Ondrej, Funasako, Moritoshi, Knecht, Sebastien, Jauvert, Gael, Chun, Julian, Eschalier, Romain, Füting, Anna, Zhao, Alexandre, Koopman, Pieter, Laredo, Mikael, Manninger, Martin, Hansen, Jim, O’Hare, Daniel, Rollin, Anne, Jurisic, Zrinka, Fink, Thomas, Chaumont, Corentin, Rillig, Andreas, Gunawerdene, Melanie, Martin, Claire, Kirstein, Bettina, Nentwich, Karin, Lehrmann, Heiko, Sultan, Arian, Bohnen, Jan, Turagam, Mohit K., Reddy, Vivek Y., Ekanem, Emmanuel, Neuzil, Petr, Reichlin, Tobias, Kautzner, Joseph, van der Voort, Pepijn, Jais, Pierre, Chierchia, Gian Battista, Bulava, Alan, Blaauw, Yuri, Skala, Tomas, Fiala, Martin, Duytschaever, Mattias, Szeplaki, Gabor, Schmidt, Boris, Massoullie, Grégoire, Neven, Kars, Thomas, Olivier, Vijgen, Johan, Gandjbakhch, Estelle, Scherr, Daniel, Johannessen, Arne, Keane, David, Boveda, Serge, Maury, Philippe, García-Bolao, Ignacio, Anic, Ante, Hansen, Peter Steen, Raczka, Franck, Lepillier, Antoine, Guyomar, Yves, Gupta, Dhiraj, Van Opstal, Jurren, Defaye, Pascal, Sticherling, Christian, Sommer, Philipp, Kucera, Pavel, Osca, Joaquin, Tabrizi, Fariborz, Roux, Antoine, Gramlich, Michael, Bianchi, Stefano, Adragão, Pedro, Solimene, Francesco, Tondo, Claudio, Russo, Antonio Dello, Schreieck, Jürgen, Luik, Armin, Rana, Obaida, Frommeyer, Gerrit, Anselme, Frédéric, Kreis, Ingo, Rosso, Raphael, Metzner, Andreas, Geller, Laszlo, Baldinger, Samuel H., Ferrero, Angel, Willems, Stephan, Goette, Andreas, Mellor, Greg, Mathew, Shibu, Szumowski, Lukasz, Tilz, Roland, Iacopino, Saverio, Jacobsen, Peter Karl, George, Andrikopoulos, Osmancik, Pavel, Spitzer, Stefan, Balasubramaniam, Richard, Parwani, Abdul Shokor, Deneke, Thomas, Glowniak, Andrzej, Rossillo, Antonio, Pürerfellner, Helmut, Duncker, David, Reil, Peter, Arentz, Thomas, Steven, Daniel, Olalla, Juan José, de Jong, Jonas S.S.G., Wakili, Reza, Abbey, Selim, Timo, Gottschling, Asso, Antonio, Wong, Tom, Pierre, Bertrand, Ewertsen, Niels Christian, Bergau, Leonard, Lozano-Granero, Cristina, Rivero, Maximo, Breitenstein, Alexander, Inkovaara, Jaakko, Fareh, Samir, Latcu, Decebal Gabriel, Linz, Dominik, Müller, Patrick, Ramos-Maqueda, Javier, Beiert, Thomas, Themistoclakis, Sakis, Meininghaus, Dirk Grosse, Stix, Günter, Tzeis, Stylianos, Baran, Jakub, Almroth, Henrik, Munoz, Daniel Rodriguez, de Sousa, João, Efremidis, Michalis, Balsam, Pawel, Petru, Jan, Küffer, Thomas, Peichl, Petr, Dekker, Lukas, Della Rocca, Domenico G., Moravec, Ondrej, Funasako, Moritoshi, Knecht, Sebastien, Jauvert, Gael, Chun, Julian, Eschalier, Romain, Füting, Anna, Zhao, Alexandre, Koopman, Pieter, Laredo, Mikael, Manninger, Martin, Hansen, Jim, O’Hare, Daniel, Rollin, Anne, Jurisic, Zrinka, Fink, Thomas, Chaumont, Corentin, Rillig, Andreas, Gunawerdene, Melanie, Martin, Claire, Kirstein, Bettina, Nentwich, Karin, Lehrmann, Heiko, Sultan, Arian, Bohnen, Jan, Turagam, Mohit K., and Reddy, Vivek Y.

Abstract

Pulsed field ablation (PFA) is an emerging technology for the treatment of atrial fibrillation (AF), for which pre-clinical and early-stage clinical data are suggestive of some degree of preferentiality to myocardial tissue ablation without damage to adjacent structures. Here in the MANIFEST-17K study we assessed the safety of PFA by studying the post-approval use of this treatment modality. Of the 116 centers performing post-approval PFA with a pentaspline catheter, data were received from 106 centers (91.4% participation) regarding 17,642 patients undergoing PFA (mean age 64, 34.7% female, 57.8% paroxysmal AF and 35.2% persistent AF). No esophageal complications, pulmonary vein stenosis or persistent phrenic palsy was reported (transient palsy was reported in 0.06% of patients; 11 of 17,642). Major complications, reported for ~1% of patients (173 of 17,642), were pericardial tamponade (0.36%; 63 of 17,642) and vascular events (0.30%; 53 of 17,642). Stroke was rare (0.12%; 22 of 17,642) and death was even rarer (0.03%; 5 of 17,642). Unexpected complications of PFA were coronary arterial spasm in 0.14% of patients (25 of 17,642) and hemolysis-related acute renal failure necessitating hemodialysis in 0.03% of patients (5 of 17,642). Taken together, these data indicate that PFA demonstrates a favorable safety profile by avoiding much of the collateral damage seen with conventional thermal ablation. PFA has the potential to be transformative for the management of patients with AF.

Published
2024

43. Proposed diagnostic criteria for arrhythmogenic cardiomyopathy:European Task Force consensus report

Author

Corrado, Domenico, Anastasakis, Aris, Basso, Cristina, Bauce, Barbara, Blomström-Lundqvist, Carina, Bucciarelli-Ducci, Chiara, Cipriani, Alberto, De Asmundis, Carlo, Gandjbakhch, Estelle, Jiménez-Jáimez, Juan, Kharlap, Maria, McKenna, William J., Monserrat, Lorenzo, Moon, James, Pantazis, Antonis, Pelliccia, Antonio, Perazzolo Marra, Martina, Pillichou, Kalliopi, Schulz-Menger, Jeanette, Jurcut, Ruxandra, Seferovic, Petar, Sharma, Sanjay, Tfelt-Hansen, Jacob, Thiene, Gaetano, Wichter, Thomas, Wilde, Arthur, Zorzi, Alessandro, Corrado, Domenico, Anastasakis, Aris, Basso, Cristina, Bauce, Barbara, Blomström-Lundqvist, Carina, Bucciarelli-Ducci, Chiara, Cipriani, Alberto, De Asmundis, Carlo, Gandjbakhch, Estelle, Jiménez-Jáimez, Juan, Kharlap, Maria, McKenna, William J., Monserrat, Lorenzo, Moon, James, Pantazis, Antonis, Pelliccia, Antonio, Perazzolo Marra, Martina, Pillichou, Kalliopi, Schulz-Menger, Jeanette, Jurcut, Ruxandra, Seferovic, Petar, Sharma, Sanjay, Tfelt-Hansen, Jacob, Thiene, Gaetano, Wichter, Thomas, Wilde, Arthur, and Zorzi, Alessandro

Abstract

Arrhythmogenic cardiomyopathy (ACM) is a heart muscle disease characterized by prominent “non-ischemic” myocardial scarring predisposing to ventricular electrical instability. Diagnostic criteria for the original phenotype, arrhythmogenic right ventricular cardiomyopathy (ARVC), were first proposed in 1994 and revised in 2010 by an international Task Force (TF). A 2019 International Expert report appraised these previous criteria, finding good accuracy for diagnosis of ARVC but a lack of sensitivity for identification of the expanding phenotypic disease spectrum, which includes left-sided variants, i.e., biventricular (ABVC) and arrhythmogenic left ventricular cardiomyopathy (ALVC). The ARVC phenotype together with these left-sided variants are now more appropriately named ACM. The lack of diagnostic criteria for the left ventricular (LV) phenotype has resulted in clinical under-recognition of ACM patients over the 4 decades since the disease discovery. In 2020, the “Padua criteria” were proposed for both right- and left-sided ACM phenotypes. The presently proposed criteria represent a refinement of the 2020 Padua criteria and have been developed by an expert European TF to improve the diagnosis of ACM with upgraded and internationally recognized criteria. The growing recognition of the diagnostic role of CMR has led to the incorporation of myocardial tissue characterization findings for detection of myocardial scar using the late‑gadolinium enhancement (LGE) technique to more fully characterize right, biventricular and left disease variants, whether genetic or acquired (phenocopies), and to exclude other “non-scarring” myocardial disease. The “ring-like’ pattern of myocardial LGE/scar is now a recognized diagnostic hallmark of ALVC. Additional diagnostic criteria regarding LV depolarization and repolarization ECG abnormalities and ventricular arrhythmias of LV origin are also provided. These proposed upgrading of diagnostic criteria represents a working framewor

Published
2024

44. A novel tool for arrhythmic risk stratification in desmoplakin gene variant carriers

Author

Electrofysiologie, Genetica Sectie Genoomdiagnostiek, Circulatory Health, Genetica Groep Van Tintelen, Child Health, Team Medisch, Carrick, Richard T, Gasperetti, Alessio, Protonotarios, Alexandros, Murray, Brittney, Laredo, Mikael, van der Schaaf, Iris, Dooijes, Dennis, Syrris, Petros, Cannie, Douglas, Tichnell, Crystal, Gilotra, Nisha A, Cappelletto, Chiara, Medo, Kristen, Saguner, Ardan M, Duru, Firat, Hylind, Robyn J, Abrams, Dominic J, Lakdawala, Neal K, Cadrin-Tourigny, Julia, Targetti, Mattia, Olivotto, Iacopo, Graziosi, Maddalena, Cox, Moniek, Biagini, Elena, Charron, Philippe, Compagnucci, Paolo, Casella, Michela, Conte, Giulio, Tondo, Claudio, Yazdani, Momina, Ware, James S, Prasad, Sanjay K, Calò, Leonardo, Smith, Eric D, Helms, Adam S, Hespe, Sophie, Ingles, Jodie, Tandri, Harikrishna, Ader, Flavie, Peretto, Giovanni, Peters, Stacey, Horton, Ari, Yao, Jessica, Schulze-Bahr, Eric, Dittman, Sven, Carruth, Eric D, Young, Katelyn, Qureshi, Maria, Haggerty, Chris, Parikh, Victoria N, Taylor, Matthew, Mestroni, Luisa, Wilde, Arthur, Sinagra, Gianfranco, Merlo, Marco, Gandjbakhch, Estelle, van Tintelen, J Peter, Te Riele, Anneline S J M, Elliot, Perry, Calkins, Hugh, Wu, Katherine C, James, Cynthia A, Electrofysiologie, Genetica Sectie Genoomdiagnostiek, Circulatory Health, Genetica Groep Van Tintelen, Child Health, Team Medisch, Carrick, Richard T, Gasperetti, Alessio, Protonotarios, Alexandros, Murray, Brittney, Laredo, Mikael, van der Schaaf, Iris, Dooijes, Dennis, Syrris, Petros, Cannie, Douglas, Tichnell, Crystal, Gilotra, Nisha A, Cappelletto, Chiara, Medo, Kristen, Saguner, Ardan M, Duru, Firat, Hylind, Robyn J, Abrams, Dominic J, Lakdawala, Neal K, Cadrin-Tourigny, Julia, Targetti, Mattia, Olivotto, Iacopo, Graziosi, Maddalena, Cox, Moniek, Biagini, Elena, Charron, Philippe, Compagnucci, Paolo, Casella, Michela, Conte, Giulio, Tondo, Claudio, Yazdani, Momina, Ware, James S, Prasad, Sanjay K, Calò, Leonardo, Smith, Eric D, Helms, Adam S, Hespe, Sophie, Ingles, Jodie, Tandri, Harikrishna, Ader, Flavie, Peretto, Giovanni, Peters, Stacey, Horton, Ari, Yao, Jessica, Schulze-Bahr, Eric, Dittman, Sven, Carruth, Eric D, Young, Katelyn, Qureshi, Maria, Haggerty, Chris, Parikh, Victoria N, Taylor, Matthew, Mestroni, Luisa, Wilde, Arthur, Sinagra, Gianfranco, Merlo, Marco, Gandjbakhch, Estelle, van Tintelen, J Peter, Te Riele, Anneline S J M, Elliot, Perry, Calkins, Hugh, Wu, Katherine C, and James, Cynthia A

Published
2024

45. Long-Term Arrhythmic Follow-Up and Risk Stratification of Patients With Desmoplakin-Associated Arrhythmogenic Right Ventricular Cardiomyopathy

Author

Team Onderzoek, Circulatory Health, Genetica, Genetica Groep Van Tintelen, Cancer, Child Health, Gasperetti, Alessio, Carrick, Richard, Protonotarios, Alexandros, Laredo, Mikael, van der Schaaf, Iris, Syrris, Petros, Murray, Brittney, Tichnell, Crystal, Cappelletto, Chiara, Gigli, Marta, Medo, Kristen, Crabtree, Peter, Saguner, Ardan M., Duru, Firat, Hylind, Robyn, Abrams, Dominic, Lakdawala, Neal K., Massie, Charles, Cadrin-Tourigny, Julia, Targetti, Mattia, Olivotto, Iacopo, Graziosi, Maddalena, Cox, Moniek, Biagini, Elena, Charron, Philippe, Casella, Michela, Tondo, Claudio, Yazdani, Momina, Ware, James S., Prasad, Sanjay, Calò, Leonardo, Smith, Eric, Helms, Adam, Hespe, Sophie, Ingles, Jodie, Tandri, Harikrishna, Ader, Flavie, Mestroni, Luisa, Wilde, Arthur, Merlo, Marco, Gandjbakhch, Estelle, Calkins, Hugh, te Riele, Anneline S.J.M., Peter van Tintelen, J., Elliot, Perry, James, Cynthia A., Team Onderzoek, Circulatory Health, Genetica, Genetica Groep Van Tintelen, Cancer, Child Health, Gasperetti, Alessio, Carrick, Richard, Protonotarios, Alexandros, Laredo, Mikael, van der Schaaf, Iris, Syrris, Petros, Murray, Brittney, Tichnell, Crystal, Cappelletto, Chiara, Gigli, Marta, Medo, Kristen, Crabtree, Peter, Saguner, Ardan M., Duru, Firat, Hylind, Robyn, Abrams, Dominic, Lakdawala, Neal K., Massie, Charles, Cadrin-Tourigny, Julia, Targetti, Mattia, Olivotto, Iacopo, Graziosi, Maddalena, Cox, Moniek, Biagini, Elena, Charron, Philippe, Casella, Michela, Tondo, Claudio, Yazdani, Momina, Ware, James S., Prasad, Sanjay, Calò, Leonardo, Smith, Eric, Helms, Adam, Hespe, Sophie, Ingles, Jodie, Tandri, Harikrishna, Ader, Flavie, Mestroni, Luisa, Wilde, Arthur, Merlo, Marco, Gandjbakhch, Estelle, Calkins, Hugh, te Riele, Anneline S.J.M., Peter van Tintelen, J., Elliot, Perry, and James, Cynthia A.

Published
2024

47. Flecainide to Prevent Atrial Arrhythmia After Patent Foramen Ovale Closure: AFLOAT Study, A Randomized Clinical Trial

Author

Hauguel-Moreau, Marie, Guedeney, Paul, Dauphin, Claire, Auffret, Vincent, Clerc, Jean-Michel, Marijon, Eloi, Elbaz, Meyer, Aldebert, Philippe, Beygui, Farzin, Abi Khalil, Wissam, Da Costa, Antoine, Macia, Jean-Christophe, Elhadad, Simon, Cayla, Guillaume, Iriart, Xavier, Laredo, Mikael, Rolland, Thomas, Temmar, Yassine, Gheorghiu, Maria Elisabeta, Brugier, Delphine, Silvain, Johanne, Hammoudi, Nadjib, Duthoit, Guillaume, Diallo, Abdourahmane, Vicaut, Eric, Montalescot, Gilles, Montalescot, Gilles, Guedeney, Paul, Silvain, Johanne, Zeitouni, Michel, Duthoit, Guillaume, Gandjbakhch, Estelle, Badenco, Nicolas, Waintraub, Xavier, Hermida, Alexis, Iriart, Xavier, Laforest, Gérald, Elbaz, Meyer, Mondoly, Pierre, Auffret, Vincent, Galand, Vincent, Barre, Valentin, Clerc, Jean Michel, Pierre, Bertrand, Saint Etienne, Christophe, Cayla, Guillaume, Macia, Jean Christophe, Dauphin, Claire, Tresorier, Romain, Boudias, Antoine, Abu Alrub, Saer, Marijon, Eloi, and Karam, Nicole

Published
2024
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50. NEXN Gene in Cardiomyopathies and Sudden Cardiac Deaths: Prevalence, Phenotypic Expression, and Prognosis

Author

Hermida, Alexis, primary, Ader, Flavie, additional, Millat, Gilles, additional, Jedraszak, Guillaume, additional, Maury, Phillipe, additional, Cador, Romain, additional, Catalan, Pierre-Antoine, additional, Clerici, Gaël, additional, Combes, Nicolas, additional, De Groote, Pascal, additional, Dupin-Deguine, Delphine, additional, Eschalier, Romain, additional, Faivre, Laurence, additional, Garcia, Patricia, additional, Guillon, Benoit, additional, Janin, Alexandre, additional, Kugener, Beatrice, additional, Lackmy, Marylin, additional, Laredo, Mikael, additional, Le Guillou, Xavier, additional, Lesaffre, François, additional, Lucron, Hugues, additional, Milhem, Antoine, additional, Nadeau, Gwenaël, additional, Nguyen, Karine, additional, Palmyre, Aurélien, additional, Perdreau, Elodie, additional, Picard, François, additional, Rebotier, Nicolas, additional, Richard, Pascale, additional, Rooryck, Caroline, additional, Seitz, Julien, additional, Verloes, Alain, additional, Vernier, Agathe, additional, Winum, Pierre, additional, Yabeta, Grace-A-Dieu, additional, Bouchot, Océane, additional, Chevalier, Philippe, additional, Charron, Philippe, additional, and Gandjbakhch, Estelle, additional

Published
2024
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