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151 results on '"García-Moreno, José Manuel"'

2. Safety and efficacy of laquinimod for Huntington's disease (LEGATO-HD): a multicentre, randomised, double-blind, placebo-controlled, phase 2 study

Author

Guttman, Mark, Raymond, Lynn, Mendis, Tilak, Suchowersky, Oksana, Corey-Bloom, Jody, Geschwind, Michael D, Marshall, Frederick J, Marder, Karen S, Nance, Martha, Racette, Brad, Bang, Jee, Segro, Victoria, McDonell, Katherine, Kamholz, John, LeDoux, Mark S, Sanchez-Ramos, Juan, DeMichele, Giuseppe, Mariotti, Caterina, Squitieri, Ferdinando, Soliveri, Paola, Cortelli, Pietro, Muñoz García, José Esteban, Kulisevsky Bojarski, Jaime, López-Sendón Moreno, José Luis, Berganzo Corrales, Koldo, Cubo, Esther, García Moreno, José Manuel, Orth, Michael, Priller, Josef, Saft, Carsten, Weindl, Adolf, Winkler, Juergen, Craufurd, David, Miedzybrodzka, Zofia, Rickards, Hugh, Davies, Rhys Richard, Lahiri, Nayana, Ruddy, Deborah, Komati, Suresh K, Quarrell, Oliver William John, Correira Guedes, Leonor, Roos, Raymund A C, Zalyalova, Zuleykha, Illarioshkin, Sergey, Gustov, Aleksandr, Klempir, Jiri, Reilmann, Ralf, Anderson, Karen E, Feigin, Andrew, Tabrizi, Sarah J, Leavitt, Blair R, Stout, Julie C, Piccini, Paola, Schubert, Robin, Loupe, Pippa, Wickenberg, Anna, Borowsky, Beth, Rynkowski, Gail, Volkinshtein, Rita, Li, Thomas, Savola, Juha-Matti, Hayden, Michael, and Gordon, Mark Forrest

Published
2024
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6. Safety and efficacy of laquinimod for Huntington's disease (LEGATO-HD): a multicentre, randomised, double-blind, placebo-controlled, phase 2 study

Author

Reilmann, Ralf, primary, Anderson, Karen E, additional, Feigin, Andrew, additional, Tabrizi, Sarah J, additional, Leavitt, Blair R, additional, Stout, Julie C, additional, Piccini, Paola, additional, Schubert, Robin, additional, Loupe, Pippa, additional, Wickenberg, Anna, additional, Borowsky, Beth, additional, Rynkowski, Gail, additional, Volkinshtein, Rita, additional, Li, Thomas, additional, Savola, Juha-Matti, additional, Hayden, Michael, additional, Gordon, Mark Forrest, additional, Guttman, Mark, additional, Raymond, Lynn, additional, Mendis, Tilak, additional, Suchowersky, Oksana, additional, Corey-Bloom, Jody, additional, Geschwind, Michael D, additional, Marshall, Frederick J, additional, Marder, Karen S, additional, Nance, Martha, additional, Racette, Brad, additional, Bang, Jee, additional, Segro, Victoria, additional, McDonell, Katherine, additional, Kamholz, John, additional, LeDoux, Mark S, additional, Sanchez-Ramos, Juan, additional, DeMichele, Giuseppe, additional, Mariotti, Caterina, additional, Squitieri, Ferdinando, additional, Soliveri, Paola, additional, Cortelli, Pietro, additional, Muñoz García, José Esteban, additional, Kulisevsky Bojarski, Jaime, additional, López-Sendón Moreno, José Luis, additional, Berganzo Corrales, Koldo, additional, Cubo, Esther, additional, García Moreno, José Manuel, additional, Orth, Michael, additional, Priller, Josef, additional, Saft, Carsten, additional, Weindl, Adolf, additional, Winkler, Juergen, additional, Craufurd, David, additional, Miedzybrodzka, Zofia, additional, Rickards, Hugh, additional, Davies, Rhys Richard, additional, Lahiri, Nayana, additional, Ruddy, Deborah, additional, Komati, Suresh K, additional, Quarrell, Oliver William John, additional, Correira Guedes, Leonor, additional, Roos, Raymund A C, additional, Zalyalova, Zuleykha, additional, Illarioshkin, Sergey, additional, Gustov, Aleksandr, additional, and Klempir, Jiri, additional

Published
2024
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7. Assessment of the Effects of Physiotherapy on Back Care and Prevention of Non-Specific Low Back Pain in Children and Adolescents: A Systematic Review and Meta-Analysis.

Author

García-Moreno, José Manuel, Calvo-Muñoz, Inmaculada, Gómez-Conesa, Antonia, and López-López, José Antonio

Subjects
PHYSICAL therapy, HEALTH literacy, RESEARCH funding, TREATMENT effectiveness, META-analysis, DESCRIPTIVE statistics, SYSTEMATIC reviews, MEDLINE, HEALTH behavior, MEDICAL databases, ANALYSIS of variance, CONFIDENCE intervals, LUMBAR pain, PREVENTIVE health services, PSYCHOLOGY information storage & retrieval systems, EVALUATION, ADOLESCENCE, CHILDREN
Abstract

Non-specific low back pain (NSLBP) in children and adolescents has increased in recent years, and the evidence of the physiotherapy interventions in back care needs to be updated. Our main goal was to quantify the effects of preventive physiotherapy interventions on improving behavior and knowledge related to back care and prevention of NSLBP in children and adolescents. Based on two previous meta-analyses, Cochrane Library, MEDLINE, PEDro, Web of Science, LILACS, IBECS, PsycINFO, and IME databases and several journals were searched. Two researchers independently extracted data and assessed the risk of bias in the studies using the RoB2 tool. Data were described according to PRISMA guidelines. A total of 24 studies (28 reports) were included. In the posttest, the behavior variable obtained an overall effect size of d+ = 1.48 (95%CI: 0.40 to 2.56), and the knowledge variable obtained an effect size of d+ = 1.41 (95%CI: 1.05 to 1.76). Physiotherapy has demonstrated beneficial impacts on behavior and knowledge concerning back care and to prevent NSLBP in children and adolescents. Interventions focusing on postural hygiene and exercise should be preferred, especially those that are shorter in number of weeks, more intense, and incorporate as many intervention hours as possible. [ABSTRACT FROM AUTHOR]

Published
2024
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8. La economía que viene: los efectos de las relaciones sociales digitales sobre el rendimiento, la coordinación y la independencia laboral

Author

Requena Santos, Félix, García Moreno, José Manuel, Requena Santos, Félix, and García Moreno, José Manuel

Abstract

The workplace is one of the environments that has most adapted to changes that have occurred in the context of the information and communication age. This study examines the effects of information and communication technologies (ICT) on Spanish workers, specifically, on their work performance, ability to coordinate with colleagues and on the possibility of achieving greater work independence. Two studies by the Spanish Centre for Sociological Research (2014 and 2016) on Digital Social Networks are used to meet this objective. The results indicate a greater probability of improving performance, coordination and work independence when using some ICT. Differences are also found in sociodemographic and socioeconomic status variables, which increase this probability in some cases when users are aware of the potential of a network of strong ties., El trabajo es uno de los ámbitos que más se ha adaptado a los cambios debidos a la era de la información y la comunicación. Este estudio examina los efectos de las tecnologías de la información y la comunicación (TIC) en los trabajadores españoles: en su rendimiento laboral, en su capacidad de coordinación con los compañeros y en la posibilidad de lograr una mayor independencia laboral. Se han usado dos encuestas del CIS (2014 y 2016) sobre Redes Sociales Digitales. Los resultados indican que la probabilidad de mejorar el rendimiento, la coordinación y la independencia laboral es mayor cuando se usan algunas TIC, existiendo además diferencias sociodemográficas y de estatus socioeconómico, aumentando esa probabilidad, cuando se usa y se tiene conciencia del potencial de la red de lazos fuertes.

Published
2023

9. The Economy that Lies Ahead. The Effects of Digital Social Relations on Work Productivity, Coordination and Independence.

Author

Requena, Félix and García-Moreno, José Manuel

Subjects
*INFORMATION & communication technologies, *SOCIAL services, *LABOR productivity, *SOCIAL networks, *JOB performance, *SOCIOECONOMIC status, *SOCIOLOGICAL research, *DIGITAL divide
Abstract

The workplace is one of the environments that has most adapted to changes that have occurred in the context of the information and communication age. This study examines the effects of information and communication technologies (ICT) on Spanish workers, specifically, on their work performance, ability to coordinate with colleagues and on the possibility of achieving greater work independence. Two studies by the Spanish Centre for Sociological Research (2014 and 2016) on Digital Social Networks are used to meet this objective. The results indicate a greater probability of improving performance, coordination and work independence when using some ICT. Differences are also found in sociodemographic and socioeconomic status variables, which increase this probability in some cases when users are aware of the potential of a network of strong ties. [ABSTRACT FROM AUTHOR]

Published
2023
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18. Dissolução do casamento em homossexuais, a quem é atribuída a guarda dos filhos?

Author

Jimenez Cabello, Jose Manuel, Becerril Ruíz, Diego, and García Moreno, José Manuel

Subjects
divorcio, ruptura, matrimonio del mismo sexo, custodia, hijos, divorce, rupture, mariage homosexuel, garde, enfants, divorce, rupture, same-sex marriage, custody, children, divórcio, separação, casamento entre pessoas do mesmo sexo, custódia, filhos
Abstract

After the implementation of Law 15/2005, there are quite a few same sex couples who have married. After 15 years, many of them have dissolved, which means that many others have been involved in child custody allocation processes. This article aims to know how custody modalities are distributed after the divorce of same-sex marriages and what social variables influence them. For this, quantitative methodology is applied, using, specifically, the Statistics on Annulments, Separations and Divorces (INE) and applying descriptive and multivariate analyses. It is concluded that shared custody is an upward modality after the dissolution of these marriages, surpassing since 2016 the exclusive modality. In addition, variables such as the possession of dependent minor or elder children, the existence of the custody law of each Autonomous Community, the age of the spouses and the judgment of the sentence, are variables that influence its modality., Tras la puesta en marcha de la Ley 15/2005 son bastantes las parejas del mismo sexo que han contraído matrimonio. Tras 15 años, muchas de ellas se han disuelto, lo que conlleva que otras tantas se hayan visto envueltas en procesos de asignación de custodia de los hijos. El presente artículo pretende conocer cómo se distribuyen las modalidades de custodia tras el divorcio de matrimonios compuestos por cónyuges del mismo sexo y que variables sociales se relacionan con las mismas. Se hace uso de metodología cuantitativa utilizando, concretamente, la Estadística de Nulidades, Separaciones y Divorcios (INE) y aplicando análisis de tipo descriptivo y multivariante. Se concluye que la custodia compartida es una modalidad al alza tras la disolución de estos matrimonios, superando desde 2016 a la modalidad exclusiva. Además, variables como la tenencia de hijos menores o mayores dependientes, la existencia de ley en materia de custodia de cada comunidade autónoma, la edad de los cónyuges y el fallo de la sentencia, son variables que influyen en la modalidad de la misma., Après l’entrée en vigueur de la loi 15/2005, de nombreux couples de même sexe ont contracté mariage. Après 15 ans, beaucoup d’entre eux ont été dissous, ce qui signifie que beaucoup d’autres ont été impliqués dans des processus d’attribution de la garde des enfants. Cet article vise à savoir comment se répartissent les modalités de garde après le divorce dans les mariages composés de conjoints de même sexe et quelles variables sociales leur sont liées. Une méthodologie quantitative est utilisée, en particulier en utilisant les statistiques de nullité, de séparation et de divorce (INE) et en appliquant une analyse descriptive et multivariée. Il est conclu que la garde partagée est une modalité en augmentation après la dissolution de ces mariages, dépassant la modalité exclusive depuis 2016. En outre, des variables telles que la possession d’enfants mineurs ou âgés à charge, l’existence d’une loi sur la garde de chaque communauté autonome, l’âge des conjoints et la décision de justice, sont des variables qui influencent la modalité de celle-ci., Após a implementação da Lei 15/2005, existem muitos casais de gays que se casaram. Após cerca de 15 anos, muitos deles se dissolveram, o que significa que muitos outros se envolveram nos processos de alocação de guarda dos filhos. Este artigo tem como objetivo conhecer como as modalidades de custódia são distribuídas após o divórcio de casamentos homossexuais e quais variáveis ​​sociais as influenciam. Para isso, utiliza-se metodologia quantitativa utilizando, especificamente, a Estatística de Anulações, Separações e Divórcios (INE). Conclui-se que a guarda compartilhada é uma modalidade ascendente após a dissolução desses casamentos, superando desde 2016 a modalidade exclusiva. Além disso, variáveis ​​como a posse de filhos menores ou mais dependentes, a existência da lei de custódia de cada Comunidade Autônoma, a idade dos cônjuges e o julgamento da sentença, são variáveis ​​que determinam sua modalidade. &nbsp

Published
2021

19. Clinical and genetic characteristics of late-onset Huntington's disease

Author

Oosterloo, Mayke, Bijlsma, Emilia K., van Kuijk, Sander MJ., Minkels, Floor, de Die-Smulders, Christine EM., Bachoud-Lévi, Anne-Catherine, Bentivoglio, Anna-Rita, Biunno, Ida, Bonelli, Raphael M., Bronzova, Juliana, Burgunder, Jean-Marc, Dunnett, Stephen B., Ferreira, Joaquim J., Frich, Jan, Giuliano, Joe, Handley, Olivia J., Heiberg, Arvid, Illarioshkin, Sergey, Illmann, Torsten, Klempir, Jiri, Landwehrmeyer, G. Bernhard, Levey, Jamie, Mclean, Tim, Nielsen, Jørgen E., Koivisto, Susana Pro, Päivärinta, Markku, Pålhagen, Sven, Quarrell, Oliver, Ramos-Arroyo, Maria, Roos, Raymund A. C., Saft, Carsten, Sebastián, Ana Rojo, Tabrizi, Sarah J., Vandenberghe, Wim, Verellen-Dumoulin, Christine, Uhrova, Tereza, Wahlström+, Jan, Zaremba, Jacek (formerly Rödig, Verena, Baake, Barth, Katrin, Garde, Monica Bascuñana, Becanovic, Kristina, Bernard, Tomáš, Betz, Sabrina, Bos, Reineke, Come, Adrien, Guedes, Leonor Correia, Callaghan, Jenny, Capodarca, Selene, Charpentier, Sébastien, Vieira da Silva, Wildson, Di Renzo, Martina, Ecker, Daniel, Finisterra, Ana Maria, Fullam, Ruth, Genoves, Camille, Gilling, Mette, Horta, Andrea, Hvalstedt, Carina, Held, Christine, Hussain, Hasina, Koppers, Kerstin, Lamanna, Claudia, Laurà, Matilde, Descals, Asunción Martínez, Martinez-Horta, Saul, Mestre, Tiago, Minster, Sara, Monza, Daniela, Münkel, Kristina, Mütze, Lisanne, Oehmen, Martin, Padieu, Helene, Paterski, Laurent, Peppa, Nadia, Rindal, Beate, Rogers, Dawn, Røren (formerly Heinonen), Niini, Salgueiro, Ana, Šašinková, Pavla, Seliverstov, Yury, Taylor, Catherine, Timewell, Erika, Townhill, Jenny, Cubillo, Patricia Trigo, van Walsem, Marleen R., Witjes-Ané, Marie-Noelle, Witkowski, Grzegorz, Wright, Abigail, Yudina, Elizaveta, Zielonka, Daniel, Zielonka, Eugeniusz, Zinzi, Paola, Hecht, Karen, Herranhof, Brigitte, Holl (formerly Hödl), Anna, Kapfhammer, Hans-Peter, Koppitz, Michael, Lilek, Sabine, Magnet, Markus, Müller, Nicole, Otti, Daniela, Painold, Annamaria, Reisinger, Karin, Scheibl, Monika, Schöggl, Helmut, Ullah, Jasmin, Braunwarth, Eva-Maria, Brugger, Florian, Buratti, Lisa, Hametner, Eva-Maria, Hepperger, Caroline, Holas, Christiane, Hotter, Anna, Hussl, Anna, Larcher, Barbara, Mahlknecht, Philipp, Müller, Christoph, Pinter, Bernadette, Poewe, Werner, Reiter, Eva-Magdalena, Seppi, Klaus, Sprenger, Fabienne, Wenning, Gregor, Ladurner, Gunther, Lilek, Stefan, Sinadinosa, Daniela, Staffen, Wolfgang, Walleczek, Anna Maria, Linder, Christoph, Pirker, Walter, Liessens, Dirk, Calmeyn, Godelinde, Somers, Nele, Delvaux, Isabelle, Boogaerts, Andrea, Flamez, Anja, de Raedt, Sylvie, Alaerts, Nick, Slama, Hichem, Supiot, Frédéric, Constant, Eric, Gillardin, Anne-Françoise, Léonard, Marie-Claude, van de Wyngaerde, Françoise, Dupuis, Michel, Minet, Cécile, Ribaï, Pascale, Van Paemel, Dominique, van Reijen, Dimphna, Weckx, Petra, Kaiserova, Michaela, Šenkárová, Zuzana, Bezdíček, Ondřej, Klempíř, Jiří, Klempířová, Olga, Majerová-Ibarburu, Veronika, Nikolai, Tomáš, Roth, Jan, Stárková, Irena, Madsen, Louise Hasselstrøm, Møller, Anette Torvin, Hjermind, Lena, Jacobsen, Oda, Larsen, Ida Unmack, Lindquist, Suzanne, Nielsen, Jørgen, Regeur, Lisbeth, Roos, Peter, Stockholm, Jette, Vangsted-Hansen, Christina, Vinther-Jensen, Tua, Lolk, Annette, Lundsgaard, Marianne, Wermuth, Lene, Andersson, Christian, Nyberg, Clara, Sundblom, Jimmy, Peippo, Maarit, Sipponen, Marjatta, Bruun, Anu, Hartikainen, Paivi, Mäkipää, Seija, Ollokainen, Mari, Åman, Jaana, Kärppä, Mikko, Ignatius, Jaakko, Jääskeläinen, Outi, Kajula, Outi, Moilanen, Jukka, Mustonen, Aki, Santala, Maire, Eklund, Pia, Hiivola, Heli, Hyppönen, Hannele, Martikainen, Kirsti, Ojala, Marjut, Tähkäpää, Sirkku, Tuuha, Katri, Allain, Philippe, Bonneau, Dominique, Bost, Marie, Gohier, Bénédicte, Guérid, Marie-Anne, Olivier, Audrey, Prouzet, Julie, Prundean, Adriana, Scherer-Gagou, Clarisse, Verny, Christophe, Babiloni, Blandine, Bled, Déborah, Debruxelles, Sabrina, Duché, Charlotte, Fraisse, Sonia, Goizet, Cyril, Jameau, Laetitia, Lafoucrière, Danielle, Spampinato, Umberto, Couttier, Julien, Debilly, Bérengère, Delaigue, Christine, Derost, Philippe, Durif, Franck, Germain, Véronique, Legendre, Perrine, Loiseau, Sylvie, Marques, Ana, Ulla, Miguel, Vidal, Tiphaine, Badei, Farideh, Boissé, Marie-Françoise, Boudali, Lotfi, Cleret de Langavant, Laurent, Lemoine, Laurie, Morgado, Graca, Youssov, Katia, Annic, Agnès, Barthélémy, Recka, De Bruycker, Christelle, Cabaret, Maryline, Carette, Anne-Sophie, Carrière, Nicolas, Decorte, Eric, Defebvre, Luc, Delliaux, Marie, Delval, Arnaud, Depelchin, Alizé, Destee, Alain, Dewulf-Pasz, Nelly, Dondaine, Thibaut, Dugauquier, Florence, Dujardin, Kathy, Hopes, Lucie, Krystkowiak, Pierre, Lemaire, Marie-Hélène, Manouvrier, Sylvie, Mutez, Eugénie, Peter, Mireille, Plomhause, Lucie, Sablonnière, Bernard, Simonin, Clémence, Tard, Céline, Thibault-Tanchou, Stéphanie, Vuillaume, Isabelle, Bellonet, Marcellin, Blin, Stéphanie, Chen, Simone, Masmoudi, Kamel, Morin, Gilles, Roussel, Martine, Tir, Mélissa, Schüler, Béatrice, Wannepain, Sandrine, Zouitina, Yassine, Azulay, Jean-Philippe, Delfini, Marie, Eusebio, Alexandre, Fluchere, Frédérique, Guenam, Aicha, Mundler, Laura, Nguyen, Karine, Benaich, Sandra, Brice, Alexis, Boster, Sarah, Charles, Perrine, Durr, Alexandra, Ewenczyk, Claire, Francisque, Hélène, Jauffret, Céline, Justo, Damian, Kassar, Abdulrahman, Klebe, Stephan, Lesne, Fabien, Milani, Paolo, Monin, Marie-Lorraine, Monnier, Tiffany, Roze, Emmanuel, Tataru, Alina, Tchikviladzé, Maya, Bioux, Sandrine, Bliaux, Evangeline, Girard, Carole, Guyant-Maréchal, Lucie, Hannequin, Didier, Hannier, Véronique, Jourdain, Séverine, Maltête, David, Pouliquen, Dorothée, Anheim, Mathieu, Barun, Nadia, Lagha-Boukbiza, Ouhaid, Longato, Nadine, Marcel, Christophe, Phillipps, Clélie, Rudolf, Gabrielle, Steinmetz, Gisèle, Tranchant, Christine, Wagner, Caroline, Zimmermann, Marie-Agathe, Blondeau, Leily, Calvas, Fabienne, Cheriet, Samia, Delabaere, Helène, Demonet, Jean-François, Marquine, Laurent, Pariente, Jérémie, Pierre, Michèle, Pomies, Elsa, Rolland, Sandrine, Souyris, Corinne, Kosinski, Christoph Michael, Milkereit, Eva, Probst, Daniela, Reetz, Kathrin, Sass, Christian, Schiefer, Johannes, Schlangen, Christiane, Werner, Cornelius J., Beuth, Markus, Gelderblom, Harald, Priller, Josef, Prüß, Harald, Spruth, Eike, Thiel, Silvia, Andrich, Jürgen, Ellrichmann, Gisa, Herrmann, Lennard, Hoffmann, Rainer, Kaminski, Barbara, Kraus, Peter, Stamm, Christiane, Ganos, Christos, Stubbe, Lars, Tadic, Vera, Tübing, Jennifer, Lange, Herwig, Bosredon, Cecile, Hunger, Ulrike, Löhle, Matthias, Maass, Antonia, Ossig, Christiana, Schmidt, Simone, Storch, Alexander, Wolz, Annett, Wolz, Martin, Kohl, Zacharias, Kozay, Christina, Winkler, Jürgen, Bergmann, Ulrike, Böringer, Regina, Capetian, Philipp, Kammel, Gerit, Lambeck, Johann, Mächtel, Miriam, Meier, Simone, Rijntjes, Michel, Zucker, Birgit, Boelmans, Kai, Goerendt, Ines, Heinicke, Walburgis, Hidding, Ute, Lewerenz, Jan, Münchau, Alexander, Orth, Michael, Schmalfeld, Jenny, Zittel, Simone, Diercks, Gabriele, Dressler, Dirk, Francis, Flverly, Gayde-Stephan, Sabine, Gorzolla, Heike, Kramer, Bianca, Minschke, Rebecca, Schrader, Christoph, Tacik, Pawel, Ribbat+, Michael, Longinus, Bernhard, Möller, Carsten, Bürk, Katrin, Lüsebrink, Antje, Mühlau, Mark, Peinemann, Alexander, Städtler, Michael, Weindl, Adolf, Winkelmann, Juliane, Ziegler, Cornelia, Bechtel, Natalie, Beckmann, Heike, Bohlen, Stefan, Göpfert, Nicole, Hölzner, Eva, Reilmann, Ralf, Rohm, Stefanie, Rumpf, Silke, Schepers, Sigrun, Weber, Nathalia, Bachmeier, Michael, Dose, Matthias, Hofstetter, Nina, Marquard, Ralf, Mühlbäck, Alzbeta, Buck, Andrea, Connemann, Julia, Geitner, Carolin, Kesse, Andrea, Landwehrmeyer, Bernhard, Lezius, Franziska, Nepper, Solveig, Niess, Anke, Schneider, Ariane, Schwenk, Daniela, Süssmuth, Sigurd, Trautmann, Sonja, Vogel, Melanie, Weydt, Patrick, Musacchio, Thomas, Leypold, Christine, Nöth, Kerstin, Cormio, Claudia, Difruscolo, Olimpia, Franco, Giovanni, Nuzzi, Angela, Sciruicchio, Vittorio, Serpino, Claudia, de Tommaso, Marina, Calandra-Buonaura, Giovanna, Capellari, Sabina, Cortelli, Pietro, Gallassi, Roberto, Poda, Roberto, Scaglione, Cesa, Agosti, Chiara, Barlati, Sergio, Compostella, Silvia, Marchina, Eleonora, Padovani, Alessando, Figorilli, Michela, Marrosu, Francesco, Muroni, Antonella, Piras, Valeria, Vacca, Melisa, Bertini, Elisabetta, Bartoli, Caterina, Fortunato, Fernanda, Ghelli, Elena, Ginestroni, Andrea, Mechi, Claudia, Paganini, Marco, Piacentini, Silvia, Pradella, Silvia, Romoli, Anna Maria, Sorbi, Sandro, Abbruzzese, Giovanni, Bandettini di Poggio, Monica, Ferrandes, Giovanna, Mandich, Paola, Marchese, Roberta, Di Maria, Emilio, Tamburini, Tiziano, Albanese, Alberto, Castagliuolo, Simona, Castaldo, Anna, Di Donato, Stefano, Di Bella, Daniela, Gellera, Cinzia, Genitrini, Silvia, Mariotti, Caterina, Nanetti, Lorenzo, Panzeri, Marta, Paridi, Dominga, Soliveri, Paola, Spagnolo, Francesca, Taroni, Franco, Tomasello, Chiara, De Michele, Giuseppe, Di Maio, Luigi, Rinaldi, Carlo, Massarelli, Marco, Peluso, Silvio, Roca, Alessandro, Russo, Cinzia Valeria, Salvatore, Elena, Sorrentino, Pierpaolo, Tucci, Tecla, Cannella, Milena, Codella, Valentina, De Gregorio, Francesca, De Nicola, Annunziata, Elifani, Francesca, Esposito, Chiara, Martino, Tiziana, Mazzante, Irene, Petrollini, Martina, Simonelli, Maria, Vezza, Maurizio, Squitieri, Ferdinando, D'Alessio, Barbara, Lovo, Francesca, Bentivoglio, Anna Rita, Bove, Francesco, Catalli, Claudio, Di Giacopo, Raffaella, Fasano, Alfonso, Frontali, Marina, Guidubaldi, Arianna, Ialongo, Tamara, Jacopini, Gioia, Loria, Giovanna, Modoni, Anna, Petracca, Martina, Piano, Carla, Chiara, Piccininni, Quaranta, Davide, Romano, Silvia, Soleti, Francesco, Solito, Marcella, Spadaro, Maria, Torlizzi, Flavia, Coarelli, Giulia, Ferraldeschi, Michela, Ristori, Giovanni, van Hout, Monique S. E., van Vugt, Jeroen P. P., Marit de Weert, A., Verhoeven, Marloes, Dekker, Meike, Klooster, Jesper, Leenders, Nico, van Oostrom, Joost, Kremer, Berry, Baake, Verena, van den Bogaard, Simon J. A., Dumas, Eve M., t Hart, Ellen P., Hogenboom, Marye, Jacobs, Milou, Jurgens, Caroline, Kampstra, Anne, Schoonderbeek, Anne, Witjes-Ané, Marie-Noëlle, Duits, Annelien, Waber, Mirella, Verstappen, Carla, Blinkenberg, Ellen Økland, Hauge, Erik, Tyvoll, Hilde, Aaserud, Olaf, Aanonsen, Nils Olaf, Bjørgo, Kathrine, Borgerød, Nancy, Dramstad, Elisabeth, Fannemel, Madeleine, Frich, Jan C., Gørvell, Per F., Haggag, Kathrine, Johannessen, Cecilie Haggag, Retterstøl, Lars, Røsby, Oddveig, Rummel, Jutta, Sikiric, Alma, Stokke, Bodil, van Walsem, Marleen, Wehus, Ragnhild, Arntsen, Vibeke, Bjørnevoll, Inga, Sando, Sigrid Botne, Haug, Marte Gjøl, Størseth, Hanna Haugan, Østern, Rune, Paulsen, Julie, Dziadkiewicz, Artur, Konkel, Agnieszka, Narożańska, Ewa, Nowak, Malgorzata, Robowski, Piotr, Sitek, Emilia, Slawek, Jaroslaw, Soltan, Witold, Szinwelski, Michal, Arkuszewski, Michał, Błaszczyk, Magdalena, Boczarska-Jedynak, Magdalena, Ciach-Wysocka, Ewelina, Gorzkowska, Agnieszka, Jasińska-Myga, Barbara, Kaczmarczyk, Aleksandra, Kłodowska – Duda, Gabriela, Opala, Grzegorz, Rudzińska, Monika, Stompel, Daniel, Banaszkiewicz, Krzysztof, Boćwińska, Dorota, Bojakowska-Jaremek, Kamila, Dec, Małgorzata, Grabska, Natalia, Krawczyk, Malgorzata, Kubowicz, Ewelina, Malec-Litwinowicz, Michalina, Stenwak, Agata, Szczudlik, Andrzej, Szczygieł, Elżbieta, Wójcik, Magdalena, Wasielewska, Anna, Anna Bryl, Jacek Anioła, Ciesielska, Anna, Klimberg, Aneta, Marcinkowski, Jerzy, Samara, Husam, Sempołowicz, Justyna, Wiśniewski, Bartłomiej, Gogol (formerly Kalbarczyk), Anna, Janik, Piotr, Jamrozik, Zygmunt, Kaminska, Anna, Kwiecinski+, Hubert, Antczak, Jakub, Jachinska, Katarzyna, Krysa, Wioletta, Rakowicz, Maryla, Rola, Rafal, Ryglewicz, Danuta, Sienkiewicz-Jarosz, Halina, Stępniak, Iwona, Sułek, Anna, Zaremba, Jacek, Zdzienicka, Elzbieta, Ziora-Jakutowicz, Karolina, Januário, Cristina, Júlio, Filipa, Almeida, Manuel, Calado, Ana, Dias, Margarida, Morgado, Joana, Semedo, Cristina, Coelho, Miguel, Magalhães, Andreia, Mendes, Tiago, Neutel, Dulce, Rodrigues, Filipe, Valadas, Anabela, Costa, Cristina, Cardoso, Helena, Santos, Mariana, Cação, Gonçalo, Cavaco, Sara, Damásio, Joana, Fernandes, Joana, Gonçalves, Alexandra, Loureiro, Rui, Moreira, Inês, Magalhães, Marina, Salgado, Paula, Andrade, Carlos, Costa, Andreia, Garrett, Carolina, Gago, Miguel, Guimarães, Joana, Massano, João, Meireles, Joana, Monteiro, Ana, Khasanova, Diana, Zalyalova, Zuleykha, Klyushnikov, Sergey, Sidorova, Olga, Smirnov, Oleg, Antonova, Victoria, Kopishinskaya, Svetlana, Korotysh, Maria, Magzhanov, Rim, Saifullina, Elena, Kurbatov, Sergey, Solis, Pilar, Herrera, Carmen Durán, Moreno, Patrocinio Garcia, Bas, Jordi, Busquets, Núria, Calopa, Matilde, Classen, Serge Jaumà, Dedichá, Nadia Rodríguez, Buongiorno, María Teresa, María, Andrés de la Cerda Santa, Muñoz, Esteban, Santacruz, Pilar, Barbera, Miquel Aguilar, Pardo, Sonia Arribas, Guia, Dolors Badenes, Calzado, Noemi, Hernanz, Laura Casas, Tartari Díaz-Zorita, Juan Pablo, Catena, Judit López, Ferrer, Pilar Quiléz, Carruesco, Gemma Tome, Robert, Misericordia Floriach, Viladrich, Cèlia Mareca, Roca, Elvira, Ruiz Idiago, Jesús Miguel, Riballo, Antonio Villa, Campolongo, Antonia, Fernandez de Bobadilla, Ramon, Bojarsky, Jaime Kulisevsky, Pagonabarraga, Javier, Perez, Jesus Perez, Ribosa, Roser, Villa, Carolina, Acera Gil, Maria Angeles, Corrales, Koldo Berganzo, Gomez Esteban, Juan Carlos, González, Amaia, Merino, Beatriz Tijero, Cubo, Esther, Polo, Cecilia Gil, Mariscal, Natividad, Sánchez, Jesús, Romero, Sandra Gutierrez, Arbelo, José Matías, Malo de Molina, Rocío, Martín, Idaira, Periañez, Juan Manuel, Udaeta, Beatriz, Alonso-Frech, Fernando, Loarte, María del Valle, Barrero, Francisco, Morales, Blas, Frades, Belén, Villanueva, Marina Ávila, Zea Sevilla, Maria Ascension, Fenollar, María del Mar, García-Ramos García, Rocío, Villanueva, Clara, Bascuñana, Mónica, Ventura, Marta Fatás, Caldentey, Juan García, Ribas, Guillermo García, García de Yébenes, Justo, López-Sendón Moreno, José Luis, Barral, Verónica Mañanes, Feliz, Cici, García Ruíz, Pedro José, García, Ana, López, Rosa Guerrero, Bárcenas, Antonio Herranz, Martínez-Descals, Asunción, Pueyo, Angel Martínez, Martin, Veronica Puertas, Martínez, Noelia Rodríguez, Montojo, Teresa, Sainz Artiga, María José, Sánchez, Vicenta, Alarcón, María Dolores, Almagro, Carmen Antúnez, Diéguez, Esther, Fortuna, Lorenza, Legaz, Agustina, Manzanares, Salvadora, Muñoz, Juan Marín, Antequera Torres, María Martirio, Perea, Fuensanta Noguera, Vivancos, Laura, González, Sonia, Guisasola, Luis Menéndez, Prieto, Marta Para, Ribacoba, René, Salvador, Carlos, Lozano, Pablo Sánchez, Ramirez, Inés Legarda, Benito, Dolors Moragues, Arques, Penelope Navas, Lopera, Monica Rodriguez, Pastor, Barbara Vives, Gaston, Itziar, Garcia-Amigot, Fermin, Martinez-Jaurrieta, Maria Dolores, Ramos-Arroyo, Maria Antonia, Adarmes, Astrid, Bernal-Escudero, Maravilla, Carrillo, Fátima, Jesús, Silvia, Mir, Pablo, Vargas-González, Laura, Hermoso, Fátima Damas, García Moreno, José Manuel, Jaramillo, Javier Abril, Lucena, Carolina Mendez, Pacheco Cortegana, Eva María, Peña, José Chacón, Redondo, Luis, Sánchez, Violeta Sánchez, Fernandez, Cristina Melgar, Romero Lemos, María Dolores, Mata, Maite Paredes, Casado, Rocío Villagrán, Bosca, Maria, Burguera, Juan Andres, Brugada, Francisco Castera, Millán Salvador, Jose Maria, Vilaplana, Carmen Peiró, Solís, Pilar, Figuerola, Begoña Jeweinat, Palanca, Paloma Millan, Diago, Elena Bellosta, López del Val, Javier, Martinez, Laura Martinez, López, Elena, Høsterey-Ugander, Ulrika, Fredlund, Gunnel, Constantinescu, Radu, Lewin, Kajsa, Neleborn-Lingefjärd, Liselotte, Berglund, Maria, Berglund, Peter, Linnsand, Petra, Petersén, Åsa, Reimer, Jan, Widner, Håkan, Esmaeilzadeh, Mouna, Tedroff, Joakim, Winnberg, Elisabeth, Benaminov, Stanislav, Björnsson, Elisabeth, Merrick, Daniel, Paucar, Martin, Svenningsson, Per, Wallden, Tina, Berglund, Måns, Loutfi, Ghada, Olofsson, Carina, Stattin, Eva-Lena, Westman, Laila, Wikström, Birgitta, Ekwall, Camilla, Göller, Marie-Lousie, Johansson, Anders, Niemelä, Valter, Nyholm, Dag, Wiklund, Leif, Koehli, Jessica, Stebler, Yanik, Kaelin, Alain, Romero, Irene, Schüpbach, Michael, Zaugg, Sabine Weber, Esposito, Federica, Good, Jean-Marc, Paus, Karin, Vingerhoets, Francois, Wider+, Christian, Jung, Hans H., Petersen, Jens A., Ligon-Auer, Maria, Mihaylova, Violeta, Downie, Lorna, Jack, Roisin, Matheson, Kirsty, Miedzybrodzka, Zosia, Rae, Daniela, Simpson, Sheila A., Summers, Fiona, Ure, Alexandra, Vaughan, Vivien, Harrower, Timothy, Vernon, Nathan, Akhtar, Shahbana, Crooks, Jenny, Curtis, Adrienne, de Souza (Keylock), Jenny, Piedad, John, Rickards, Hugh, Wright, Jan, Haig-Brown, Diane, Craven, Janet, Pallett, Andrew, Simpson, Steve, Weekes, Rebecca, Coulthard, Elizabeth, Gethin, Louise, Hayward, Beverley, Sieradzan, Kasia, Barker, Roger A., O'Keefe, Deidre, Gerrtiz (nee Di Pietro), Anna, Fisher, Kate, Goodman, Anna, Hill, Susan, Mason, Sarah, Swain, Rachel, Guzman, Natalie Valle, Busse, Monica, Butcher, Cynthia, Dunnett, Stephen, Clenaghan, Catherine, Hunt, Sarah, Jones, Lesley, Jones, Una, Khalil, Hanan, Owen, Michael, Price, Kathleen, Rosser, Anne, Goudie, David, Buchanan, Lindsay, Mcfadyen, Paula, Tonner, Alison, Taylor, Anne-Marie, Edwards, Maureen, Carrie, Ho, Mcgill, Marie, Porteous, Mary, Pearson, Pauline, Irvine, Sarah, Brockie, Peter, Foster, Jillian, Johns, Nicola, Mckenzie, Sue, Rothery, Jean, Thomas, Gareth, Yates, Shona, Neumann, Christian, Patterson, Kirsten, Thomson, David, Deith, Catherine, Ireland, Jane, Ritchie, Stuart, Brown, Pauline, Burrows, Liz, Fletcher, Amy, Harding, Alison, Harrison, Kaye, Laver, Fiona, Silva, Mark, Thomson, Aileen, Chu, Carol, Evans, Carole, Gallentree, Deena, Hamer, Stephanie, Kraus, Alison, Markova, Ivana, Raman, Ashok, Rowett, Liz, Andrew, Alyson, Frost, Julie, Noad, Rupert, Cosgrove, Jeremy, Gallantree, Deena, Hobson, Emma, Jamieson, Stuart, Longthorpe, Mandy, Musgrave, Hannah, Peacy, Caroline, Toscano, Jean, Wild, Sue, Yardumian, Pam, Clayton, Carole, Dipple, Heather, Freire-Patino, Dawn, Hallam, Caroline, Middleton, Julia, Alusi, Sundus, Davies, Rhys, Foy, Kevin, Gerrans, Emily, Pate, Louise, Anjum, Uruj, Coebergh, Jan, Eddy, Charlotte, Lahiri, Nayana, Mcentagart, Meriel, Patton, Michael, Peterson, Maria, Rose, Sarah, Andrews, Thomasin, Dougherty, Andrew, Golding, Charlotte, Kavalier, Fred, Laing, Hana, Lashwood, Alison, Robertson, Dene, Ruddy, Deborah, Santhouse, Alastair, Whaite, Anna, Gosling (nee Brown), Stefanie, Bruno, Stefania, Chu, Elvina, Doherty, Karen, Haider, Salman, Hensman, Davina, Lewis, Monica, Novak, Marianne, Patel, Aakta, Robertson, Nicola, Rosser, Elisabeth, Tabrizi, Sarah, Taylor, Rachel, Warner, Thomas, Wild, Edward, Ackermann, Oda, Duport, Sophie, Scott, Adrienne, Stoy, Nicholas, Vaughn, Jenny, Arran, Natalie, Bek, Judith, Craufurd, David, Hare, Marianne, Howard, Liz, Huson, Susan, Johnson, Liz, Jones, Mary, Krishnamoorthy, Ashok, Murphy, Helen, Oughton, Emma, Partington-Jones, Lucy, Sollom, Andrea, Snowden, Julie, Stopford, Cheryl, Thompson, Jennifer, Trender-Gerhard, Iris, Verstraelen (formerly Ritchie), Nichola, Westmoreland, Leann, Cass, Ginette, Davidson, Lynn, Davison, Jill, Fullerton, Neil, Holmes, Katrina, Komati, Suresh, Mcdonnell, Sharon, Mohammed, Zeid, Morgan, Karen, Savage, Lois, Singh, Baldev, Wood, Josh, Knight, Caroline, O'Neill, Mari, Purkayastha, Debasish Das, Nemeth, Andrea H., Siuda, Gill, Valentine, Ruth, Dixon, Kathryn, Armstrong, Richard, Harrison, David, Hughes, Max, Large, Sandra, Donovan, John O., Palmer, Amy, Parkinson, Andrew, Soltysiak, Beverley, Timings, Leanne, Williams, Josh, Burn, John, Bailey, Wendy, Coleman, Caroline, Majeed, Tahir, Verstraelen (Ritchie), Nicola, Barrett, Wendy, Aileen, Ho, Bandmann, Oliver, Bradbury, Alyson, Fairtlough, Helen, Fillingham, Kay, Foustanos, Isabella, Gill, Paul, Kazoka, Mbombe, O'Donovan, Kirsty, Nevitt, Louise, Taylor, Cat, Tidswell, Katherine, Kipps, Christopher, Mackinnon, Lesley, Agarwal, Veena, Hayward, Elaine, Gunner, Kerry, Harris, Kayla, Anderson, Mary, Heywood, Melanie, Keys, Liane, Smalley, Sarah, El-Nimr, George, Duffell, Allison, Wood, Sue, Kennedy (nee Smith), Karen, Gowers, Lesley, Powell, Kingsley, Bethwaite, Pamela, Edwards, Rachel, Fuller, Kathleen, Phillips, Michelle, Tan, Louis, Lau, Puay Ngoh, Pica, Emmanuel, Roos, Raymund AC., Klinische Neurowetenschappen, MUMC+: MA Med Staf Spec Neurologie (9), MUMC+: KIO Kemta (9), Epidemiologie, RS: CAPHRI - R2 - Creating Value-Based Health Care, Klinische Genetica, MUMC+: DA KG Polikliniek (9), and RS: GROW - R4 - Reproductive and Perinatal Medicine

Subjects
Male, HD, 0301 basic medicine, Pediatrics, Neurology, Huntingtin Protein/genetics, FEATURES, Disease, Neuropsychological Tests, 0302 clinical medicine, Cognitive Dysfunction/psychology, Medicine, Family history, Postural Balance, Huntington Disease/genetics, Huntingtin Protein, education.field_of_study, Chorea/physiopathology, Huntington's disease, Sensation Disorders/physiopathology, Middle Aged, Dystonia, Settore MED/26 - NEUROLOGIA, Huntington Disease, neurodegenerative disorders, Sensation Disorders, Disease Progression, Female, medicine.symptom, Adult, medicine.medical_specialty, Population, Age of onset, Late-onset Huntington's disease, Geriatrics and Gerontology, Neurology (clinical), 03 medical and health sciences, AGE, Chorea, Humans, Cognitive Dysfunction, education, Dystonia/physiopathology, Gait Disorders, Neurologic/physiopathology, Gait Disorders, Neurologic, business.industry, medicine.disease, Gait, 030104 developmental biology, Trinucleotide Repeat Expansion, business, 030217 neurology & neurosurgery, Balance problems
Abstract

Background: The frequency of late-onset Huntington's disease (>59 years) is assumed to be low and the clinical course milder. However, previous literature on late-onset disease is scarce and inconclusive. Objective: Our aim is to study clinical characteristics of late-onset compared to common-onset HD patients in a large cohort of HD patients from the Registry database. Methods: Participants with late- and common-onset (30–50 years)were compared for first clinical symptoms, disease progression, CAG repeat size and family history. Participants with a missing CAG repeat size, a repeat size of ≤35 or a UHDRS motor score of ≤5 were excluded. Results: Of 6007 eligible participants, 687 had late-onset (11.4%) and 3216 (53.5%) common-onset HD. Late-onset (n = 577) had significantly more gait and balance problems as first symptom compared to common-onset (n = 2408) (P

Published
2019
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20. Staging Parkinson's Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life

Author

Santos García, Diego, Deus Fonticoba, María Teresa de, Paz González, J. M., Cores Bartolomé, C., Valdés Aymerich, L., Muñoz Enríquez, J. G., Suárez, E., Jesús, S., Aguilar Barberà, Miquel, Pastor, P., Planellas, L. L., Cosgaya, M., García Caldentey, J., Caballol, N., Legarda, I., Hernández-Vara, Jorge, Cabo, I., López Manzanares, L., González Aramburu, I., Ávila-Rivera, M. A, Catalán, M. J., Nogueira, V., Puente, V., García Moreno, José Manuel, Borrué, C., Solano Vila, B., Álvarez Sauco, M., Vela, Lydia, Escalante, S., Cubo, Esther, Carrillo Padilla, F., Martínez Castrillo, J. C., Sánchez Alonso, P., Alonso Losada, M. G., López Ariztegui, N., Gastón, I., Kulisevsky, Jaime, Blázquez Estrada, M., Seijo, M., Rúiz Martínez, J., Valero, C., Kurtis, M., Fàbregues-Boixar i Nebot, Oriol de, González Ardura, J., Ordás, C., López Díaz, L., Mir, P., Martinez-Martin, Pablo, COPPADIS Study Group, None, Universitat Autònoma de Barcelona, Institut Català de la Salut, [Santos García D, Paz González JM, Cores Bartolomé C, Valdés Aymerich L, Muñoz Enríquez JG] CHUAC, Complejo Hospitalario Universitario de A Coruña, A Coruña, Spain. [De Deus Fonticoba T] CHUF, Complejo Hospitalario Universitario de Ferrol, A Coruña, Spain. [Hernández Vara J, de Fábregues O] Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus, Universidad de Sevilla. Departamento de Medicina, [Santos Garcia, D.] Complejo Hosp Univ A Coruna, CHUAC, La Coruna, Spain, [Paz Gonzalez, J. M.] Complejo Hosp Univ A Coruna, CHUAC, La Coruna, Spain, [Cores Bartolome, C.] Complejo Hosp Univ A Coruna, CHUAC, La Coruna, Spain, [Valdes Aymerich, L.] Complejo Hosp Univ A Coruna, CHUAC, La Coruna, Spain, [Munoz Enriquez, J. G.] Complejo Hosp Univ A Coruna, CHUAC, La Coruna, Spain, [De Deus Fonticoba, T.] Complejo Hosp Univ Ferrol, CHUF, La Coruna, Spain, [Suarez, E.] Complejo Hosp Univ Ferrol, CHUF, La Coruna, Spain, [Jesus, S.] Univ Seville, Serv Neurol & Neurofisiol Clin, Unidad Trastornos Movimiento, Hosp Univ Virgen Rocio,CSIC,Inst Biomed Sevilla, Seville, Spain, [Mir, P.] Univ Seville, Serv Neurol & Neurofisiol Clin, Unidad Trastornos Movimiento, Hosp Univ Virgen Rocio,CSIC,Inst Biomed Sevilla, Seville, Spain, [Jesus, S.] Ctr Invest Biomed Red Enfermedades Neurodegnerat, CIBERNED, Madrid, Spain, [Gonzalez Aramburu, I.] Ctr Invest Biomed Red Enfermedades Neurodegnerat, CIBERNED, Madrid, Spain, [Kulisevsky, J.] Ctr Invest Biomed Red Enfermedades Neurodegnerat, CIBERNED, Madrid, Spain, [Mir, P.] Ctr Invest Biomed Red Enfermedades Neurodegnerat, CIBERNED, Madrid, Spain, [Martinez-Martin, P.] Ctr Invest Biomed Red Enfermedades Neurodegnerat, CIBERNED, Madrid, Spain, [Aguilar, M.] Hosp Univ Mutua Terrassa, Terrassa, Spain, [Pastor, P.] Hosp Univ Mutua Terrassa, Terrassa, Spain, [Planellas, L. L.] Hosp Clin Barcelona, Barcelona, Spain, [Cosgaya, M.] Hosp Clin Barcelona, Barcelona, Spain, [Garcia Caldentey, J.] Ctr Neurol Oms 42, Palma de Mallorca, Spain, [Caballol, N.] Hosp Moises Broggi, Consorci Sanitari Integral, Barcelona, Spain, [Legarda, I.] Hosp Univ Son Espases, Palma de Mallorca, Spain, [Hernandez Vara, J.] Hosp Univ Vall Hebron, Barcelona, Spain, [de Fabregues, O.] Hosp Univ Vall Hebron, Barcelona, Spain, [Cabo, I.] Complejo Hosp Univ Pontevedra CHOP, Pontevedra, Spain, [Seijo, M.] Complejo Hosp Univ Pontevedra CHOP, Pontevedra, Spain, [Lopez Manzanares, L.] Hosp Univ La Princesa, Madrid, Spain, [Gonzalez Aramburu, I.] Hosp Univ Marques Valdecilla, Santander, Spain, [Avila Rivera, M. A.] Hosp Gen Hosp, Consorci Sanitari Integral, Barcelona, Spain, [Catalan, M. J.] Hosp Univ Clin San Carlos, Madrid, Spain, [Nogueira, V.] Hosp Da Costa, Lugo, Spain, [Puente, V.] Hosp del Mar, Barcelona, Spain, [Garcia Moreno, J. M.] Hosp Univ Virgen Macarena, Seville, Spain, [Borrue, C.] Hosp Infanta Sofia, Madrid, Spain, [Solano Vila, B.] Inst Catala Salut, Inst Assistencia Sanitaria IAS, Girona, Spain, [Alvarez Sauco, M.] Hosp Gen Univ Elche, Elche, Spain, [Vela, L.] Fdn Hosp Alcorcon, Madrid, Spain, [Escalante, S.] Hosp Tortosa Verge Cinta IITVC, Tarragona, Spain, [Cubo, E.] Complejo Asistencial Univ Burgos, Burgos, Spain, [Carrillo Padilla, F.] Hosp Univ Canarias, San Cristobal De Laguna, Santa Cruz De T, Spain, [Martinez Castrillo, J. C.] Hosp Univ Ramon y Cajal, Madrid, Spain, [Sanchez Alonso, P.] Hosp Univ Puerta Hierro, Madrid, Spain, [Alonso Losada, M. G.] Complejo Hosp Univ Vigo CHUVI, Hosp Alvaro Cunqueiro, Vigo, Spain, [Lopez Ariztegui, N.] Complejo Hosp Toledo, Toledo, Spain, [Gaston, I.] Complejo Hosp Navarra, Pamplona, Spain, [Kulisevsky, J.] Hosp Santa Creu & Sant Pau, Barcelona, Spain, [Blazquez Estrada, M.] Hosp Univ Cent Asturias, Oviedo, Spain, [Ruiz Martinez, J.] Hosp Univ Donostia, San Sebastian, Spain, [Valero, C.] Hosp Arnau Vilanova, Valencia, Spain, [Kurtis, M.] Hosp Ruber Int, Madrid, Spain, [Gonzalez Ardura, J.] Hosp Univ Lucus Augusti HULA, Lugo, Spain, [Ordas, C.] Hosp Rey Juan Carlos, Madrid, Spain, [Lopez Diaz, L.] Complejo Hosp Univ Orense CHUO, Orense, Spain, and [COPPADIS Study Grp] Fdn Curemos Parkinson, C Juana Vega 23 2, La Coruna 15004, Spain

Subjects
medicine.medical_specialty, Discapacitats, Parkinson's disease, Article Subject, Degenerative Disorder, Parkinson, Malaltia de - Prognosi, Neuroscience (miscellaneous), Disease, Stage ii, personas::personas con discapacidad [DENOMINACIONES DE GRUPOS], Parkinson’s Disease, 03 medical and health sciences, 0302 clinical medicine, Quality of life, enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::enfermedades de los ganglios basales::trastornos parkinsonianos::enfermedad de Parkinson [ENFERMEDADES], Malaltia de Parkinson, Internal medicine, medicine, Motor and nonmotor symptoms (NMS), Stage (cooking), RC346-429, 030304 developmental biology, ambiente y salud pública::salud pública::medidas epidemiológicas::demografía::estado de salud::calidad de vida [ATENCIÓN DE SALUD], Subtypes, 0303 health sciences, Questionnaire, business.industry, Neurodegenerative disorder, medicine.disease, humanities, Scale, Psychiatry and Mental health, Environment and Public Health::Public Health::Epidemiologic Measurements::Demography::Health Status::Quality of Life [HEALTH CARE], Impact, Persons::Disabled Persons [NAMED GROUPS], Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Basal Ganglia Diseases::Parkinsonian Disorders::Parkinson Disease [DISEASES], Neurology. Diseases of the nervous system, Neurology (clinical), Stage iv, business, 030217 neurology & neurosurgery, Qualitat de vida - Avaluació, Research Article
Abstract

COPPADIS Study Group., [Introduction] In a degenerative disorder such as Parkinson’s disease (PD), it is important to establish clinical stages that allow to know the course of the disease. Our aim was to analyze whether a scale combining Hoehn and Yahr’s motor stage (H&Y) and the nonmotor symptoms burden (NMSB) (assessed by the nonmotor symptoms scale (NMSS)) provides information about the disability and the patient’s quality of life (QoL) with regard to a defined clinical stage., [Materials and Methods] Cross-sectional study in which 603 PD patients from the COPPADIS cohort were classified according to H&Y (1, stage I; 2, stage II; 3, stage III; 4, stage IV/V) and NMSB (A: NMSS = 0–20; B: NMSS = 21–40; C: NMSS = 41–70; D: NMSS ≥ 71) in 16 stages (HY.NMSB, from 1A to 4D). QoL was assessed with the PDQ-39SI, PQ-10, and EUROHIS-QOL8 and disability with the Schwab&England ADL (Activities of Daily Living) scale., [Results] A worse QoL and greater disability were observed at a higher stage of H&Y and NMSB (). Combining both (HY.NMSB), patients in stages 1C and 1D and 2C and 2D had significantly worse QoL and/or less autonomy for ADL than those in stages 2A and 2B and 3A and 3B, respectively (; e.g., PDQ-39SI in 1D [n = 15] vs 2A [n = 101]: 28.6 ± 17.1 vs 7.9 ± 5.8; )., [Conclusion] The HY.NMSB scale is simple and reflects the degree of patient involvement more accurately than the H&Y. Patients with a lower H&Y stage may be more affected if they have a greater NMS burden.

Published
2021

21. Parentalidad Postdivorcio: Características Relacionadas con la Asignación de la Custodia de Hijos e Hijas tras la Ruptura de Matrimonios Heterosexuales. El Caso de Andalucía

Author

Jiménez Cabello, José Manuel, Puertas Cañaveral, Inmaculada Cristina, Paniza Prados, José Luis, and García Moreno, José Manuel

Subjects
Cuantitativo, Divorcio, Heterosexuales, Divorce, Custodia, Heterosexual, Andalucía, Familia, Family, Custody, Andalusia, Quantitative
Abstract

Al Ministerio de Ciencia, Innovación y Universidades ya que la presente investigación cuenta con financiación del programa para la ayuda de formación de profesorado universitario (FPU). La presente investigación se centra en identificar la relación de determinadas variables sociales con la asignación de la custodia tras el divorcio de matrimonios heterosexuales en Andalucía. Para ello se emplea metodología cuantitativa, utilizando la Estadística de Nulidades, Separaciones y Divorcios (INE, 2017) y datos de indicadores económicos como el Producto Interior Bruto (2017). Su explotación permite tener en cuenta todo un conjunto de variables necesarias para comprender el fenómeno objeto de estudio. Se realizan análisis de tipo descriptivo y multivariante (análisis factorial y de correspondencias). Los principales resultados obtenidos confirman que variables como el número de hijos menores o mayores dependientes, el fallo de la sentencia y el PIB de cada provincia, están relacionadas significativamente con la modalidad de custodia finalmente asignada. Otras variables como la edad de los cónyuges o su nacionalidad no parecen tener asociación en la modalidad que se otorga. This research focuses on the analysis of the variables of a social nature that affect the assignment of custody after divorce from heterosexual marriages in Andalusia. For this, a quantitative methodology is used, using the Statistics of Nullities, Separations and Divorces (INE, 2017) and data from economic indicators such as Gross Domestic Product (2017). Its exploitation allows taking into account a whole set of variables necessary to understand the phenomenon under study. Descriptive and multivariate analyzes are carried out (factorial and correspondence analysis). The main results obtained confirm that variables such as the number of dependent minor children or dependent children of legal age, the judgment failure and the GDP of each province are significantly related to the custody modality finally assigned. Other variables such as the age of the spouses or their nationality do not seem to have an association in the modality that is granted. Ministerio de Ciencia, Innovación y Universidades (FPU)

Published
2021

22. Predictors of clinically significant quality of life impairment in Parkinson's disease

Author

Santos García, Diego, de Deus Fonticoba, Teresa, Cores Bartolomé, Carlos, Muñoz, G., Paz González, J. M., Martínez Miró, C., Suárez, E., Jesús, S., Aguilar Barberà, Miquel, Pastor, P., Planellas, L., Cosgaya, Marina, García Caldentey, J., Caballol, Nuria, Legarda, I., Hernández-Vara, Jorge, Cabo-Lopez, Iria, López Manzanares, L., González Aramburu, I., Ávila, Asunción, Catalán, M. J., Nogueira, V., Puente, V., Ruíz de Arcos, M., Borrué, Carmen, Solano Vila, B., Álvarez Sauco, M., Vela, Lydia, Escalante, Sonia, Cubo, Esther, Carrillo Padilla, Francisco, Martínez-Castrillo, Juan Carlos, Sánchez Alonso, P., Alonso Losada, M. G., López Ariztegui, N, Gastón, I., Clavero, P., Kulisevsky, Jaime, Blázquez Estrada, Marta, Seijo, M., Rúiz Martínez, J., Valero, C., Kurtis, M., Fàbregues-Boixar i Nebot, Oriol de, González-Ardura, J, Ordás, C., López Díaz, L. M., McAfee, D., Martinez-Martin, P., Mir, P., Adarmes, D. A., Almeria, Marta, Alonso-Cánovas, Araceli, Alonso Frech, Fernando, Alonso Redondo, Rubén, Álvarez, I., Aneiros Díaz, Á., Arnáiz, S., Arribas, S., Ascunce Vidondo, A., Bernardo Lambrich, N., Bejr-Kasem Marco, Helena, Botí, M. Ángeles, Buongiorno, M. T., Cabello González, C., Cámara, Ana, Canfield Medina, H., Carrillo, F., Casas, E., Cortina Fernández, A., Cots-Foraster, Anna, Crespo Cuevas, Ane Miren, Díez-Fairen, M., Dotor García-Soto, J., Erro, E., Estelrich Peyret, E., Fernández Guillán, N., Gámez, Pedro, Gallego, Miguel, García Campos, C., García Moreno, José Manuel, Gómez Garre, M. P., Gómez Mayordomo, V., González Aloy, J., González García, B., González Palmás, M. J., Toledo, G., Gabriel, R., Golpe Díaz, A., Grau Solá, M., Guardia, G., Horta, Andrea, Idoate Calderón, D., Infante, J., Labandeira, C., Labrador-Espinosa, Miguel A, Lacruz, F., Lage Castro, M., Lastres Gómez, S., López Seoane, B., Lucas del Pozo, S., Macías, Y., Mata, M., Martí Andres, G., Martí, M. J., Meitín, M. T., Menéndez González, M., Méndez del Barrio, C., Miranda Santiago, J., Casado, M., María, I., Moreno Diéguez, A., Novo Amado, A., Novo Ponte, S., Pagonabarraga Mora, Javier, Pareés, I., Pascual-Sedano, Berta María, Pérez Fuertes, A., Pérez Noguera, R., Planas-Ballvé, A., Prats, M. A., Prieto Jurczynska, C., Pueyo Morlans, M., Puig-Davi, Arnau, Redondo Rafales, N., Rodríguez Méndez, L., Rodríguez Pérez, A. B., Roldán, F., Sánchez-Carpintero, M., Sánchez Díez, G., Sánchez Rodríguez, A., Santacruz, P., Segundo Rodríguez, J. C., Sierra Peña, M., Tartari, J. P., Vargas, L., Villanueva, C., Vives-Pastor, B, Villar, M. D., Institut Català de la Salut, [Santos García D, Cores C, Muñoz G, Paz González JM, Martínez Miró C] CHUAC, Complejo Hospitalario Universitario de A Coruña, A Coruña, Spain. [de Deus Fonticoba T] CHUF, Complejo Hospitalario Universitario de Ferrol, A Coruña, Spain. [Hernández Vara J, de Fábregues O] Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus, Universidad de Cantabria, AbbVie Pharmaceuticals, Abbott Laboratories, Allergan Foundation, BIAL Foundation, Merz Pharma, UCB Pharma, Zambon, Ministerio de Economía y Competitividad (España), Instituto de Salud Carlos III, European Commission, Junta de Andalucía, Sociedad Andaluza de Neurología, Jacques and Gloria Gossweiler Foundation, Fundación Alicia Koplowitz, and Fundación Mutua Madrileña

Subjects
Quality of life, Qualitat de vida--Avaluació, Parkinson's disease, Parkinson, Malaltia de - Prognosi, Nervous System Diseases::Nervous System Diseases::Nervous System Diseases::Neurodegenerative Diseases::Parkinson Disease [DISEASES], Article, humanities, Environment and Public Health::Public Health::Epidemiologic Measurements::Demography::Health Status::Quality of Life [HEALTH CARE], Cellular and Molecular Neuroscience, enfermedades del sistema nervioso::enfermedades del sistema nervioso::enfermedades del sistema nervioso::enfermedades neurodegenerativas::enfermedad de Parkinson [ENFERMEDADES], Neurology, Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Progression::Clinical Deterioration [DISEASES], Neurology. Diseases of the nervous system, Neurology (clinical), Parkinson, Malaltia de, RC346-429, afecciones patológicas, signos y síntomas::procesos patológicos::atributos de la enfermedad::progresión de la enfermedad::deterioro clínico [ENFERMEDADES], Qualitat de vida - Avaluació, ambiente y salud pública::salud pública::medidas epidemiológicas::demografía::estado de salud::calidad de vida [ATENCIÓN DE SALUD]
Abstract

COPPADIS Study Group., Quality of life (QOL) plays an important role in independent living in Parkinson’s disease (PD) patients, being crucial to know what factors impact QoL throughout the course of the disease. Here we identified predictors of QoL impairment in PD patients from a Spanish cohort. PD patients recruited from 35 centers of Spain from the COPPADIS cohort from January 2016, to November 2017, were followed up during 2 years. Health-related QoL (HRQoL) and global QoL (GQoL) were assessed with the 39-item Parkinson’s disease Questionnaire (PDQ-39) and the EUROHIS-QOL 8-item index (EUROHIS-QOL8), respectively, at baseline (V0) and at 24 months ± 1 month (V2). Clinically significant QoL impairment was defined as presenting an increase (PDQ-39SI) or decrement (EUROHIS-QOL8) at V2 ≥ 10% of the score at baseline (V0). A comparison with a control group was conducted for GQoL. GQoL did not change significantly in PD patients (N = 507; p = 0.686) or in the control group (N = 119; p = 0.192). The mean PDQ-39SI was significantly increased in PD patients (62.7 ± 8.5 years old; 58.8% males; N = 500) by 21.6% (from 16.7 ± 13 to 20.3 ± 16.4; p, Mir P. has received honoraria from AbbVie, Abbott, Allergan, Bial, Merz, UCB and Zambon and have received grants from the Spanish Ministry of Economy and Competitiveness [PI16/01575] co-founded by ISCIII (Subdirección General de Evaluación y Fomento de la Investigación) and by Fondo Europeo de Desarrollo Regional (FEDER), the Consejería de Economía, Innovación, Ciencia y Empleo de la Junta de Andalucía [CVI-02526, CTS-7685], the Consejería de Salud y Bienestar Social de la Junta de Andalucía [PI-0437-2012, PI-0471-2013], the Sociedad Andaluza de Neurología, the Jacques and Gloria Gossweiler Foundation, the Fundación Alicia Koplowitz, the Fundación Mutua Madrileña.

Published
2021

23. Parentalidad postdivorcio: características relacionadas con la asignación de la custodia de hijos e hijas tras la ruptura de matrimonios heterosexuales. El caso de Andalucía

Author

Ministerio de Ciencia, Innovación y Universidades (MICINN). España, Jiménez Cabello, José Manuel, Puertas Cañaveral, Inmaculada, Paniza Prados, José Luis, García Moreno, José Manuel, Ministerio de Ciencia, Innovación y Universidades (MICINN). España, Jiménez Cabello, José Manuel, Puertas Cañaveral, Inmaculada, Paniza Prados, José Luis, and García Moreno, José Manuel

Abstract

La presente investigación se centra en identificar la relación de determinadas variables sociales con la asignación de la custodia tras el divorcio de matrimonios heterosexuales en Andalucía. Para ello se emplea metodología cuantitativa, utilizando la Estadística de Nulidades, Separaciones y Divorcios (INE, 2017) y datos de indicadores económicos como el Producto Interior Bruto (2017). Su explotación permite tener en cuenta todo un conjunto de variables necesarias para comprender el fenómeno objeto de estudio. Se realizan análisis de tipo descriptivo y multivariante (análisis factorial y de correspondencias). Los principales resultados obtenidos confirman que variables como el número de hijos menores o mayores dependientes, el fallo de la sentencia y el PIB de cada provincia, están relacionadas significativamente con la modalidad de custodia finalmente asignada. Otras variables como la edad de los cónyuges o su nacionalidad no parecen tener asociación en la modalidad que se otorga., This research focuses on the analysis of the variables of a social nature that affect the assignment of custody after divorce from heterosexual marriages in Andalusia. For this, a quantitative methodology is used, using the Statistics of Nullities, Separations and Divorces (INE, 2017) and data from economic indicators such as Gross Domestic Product (2017). Its exploitation allows taking into account a whole set of variables necessary to understand the phenomenon under study. Descriptive and multivariate analyzes are carried out (factorial and correspondence analysis). The main results obtained confirm that variables such as the number of dependent minor children or dependent children of legal age, the judgment failure and the GDP of each province are significantly related to the custody modality finally assigned. Other variables such as the age of the spouses or their nationality do not seem to have an association in the modality that is granted.

Published
2021

24. Asignación de la custodia tras el divorcio: diferencias y similitudes en el caso de disoluciones de parejas heterosexuales y homosexuales

Author

Becerril Ruiz, Diego, Jiménez Cabello, José Manuel, García Moreno, José Manuel, Becerril Ruiz, Diego, Jiménez Cabello, José Manuel, and García Moreno, José Manuel

Abstract

Custody assignment after divorce is an increasingly recurrent area of study. The literature on this topic has tended to consider the dissolution of only heterosexual couples. Therefore, this article examines the influence of certain social variables and detects potential differences or similarities between heterosexual and homosexual couples in Spain. Quantitative methodology was used, along with descriptive and multivariate analyses, with data from the Annulments, Separations and Divorces Statistics (ENSD) of the Spanish National Statistics Institute (INE). The main conclusion reached is that shared custody is more commonly assigned in homosexual couples as compared to heterosexual ones. The number of children, the presence of conflict during the divorce proceedings and the specific Spanish autonomous community are variables that are key to understanding the assigned custody modality., La asignación de la custodia es un ámbito de estudio cada vez más recurrente. La literatura muestra que el interés por esta temática se ha centrado, principalmente, en disoluciones de parejas heterosexuales. El presente artículo pretende conocer, para el caso de España, cómo influyen determinadas variables sociales, y detectar posibles diferencias o similitudes en el caso de parejas heterosexuales y homosexuales. Se utiliza metodología cuantitativa con análisis descriptivo y multivariante, usando la Estadística de Nulidades, Separaciones y Divorcios (ENSD) del Instituto Nacional de Estadística (INE). La conclusión principal es que la modalidad de custodia compartida está más presente en el caso de parejas homosexuales que en heterosexuales, siendo el número de hijos, la conflictividad en el proceso de divorcio y la comunidad autónoma (CC. AA.) claves para entender qué modalidad de custodia se asigna.

Published
2021

25. Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s disease

Author

Curemos el Párkinson, Martínez-Horta, Saúl, Bejr-Kasem, Helena, Horta-Barba, Andrea, Pascual-Sedano, Berta, Santos-García, Diego, Deus Fonticoba, T. de, Jesús Maestre, Silvia, Aguilar Barberá, Miquel, Planellas, Lluís, García Caldentey, Juan, Caballol, Nuria, Vives-Pastor, Bárbara, Hernández-Vara, Jorge, Cabo-Lopez, Iria, López-Manzanares, Lydia, González-Aramburu, Isabel, Ávila-Rivera, María A., Catalán, M. J., López-Díaz, Luis M., Puente, Víctor, García-Moreno, José Manuel, Borrué, Carmen, Solano Vila, Berta, Álvarez-Sauco, María, Vela, Lydia, Escalante, Sonia, Cubo, Esther, Carrillo Padilla, Francisco, Martínez-Castrillo, J. C., Sánchez Alonso, Pilar, Alonso Losada, María G., López-Ariztegui, Nuria, Gastón, Itziar, Blázquez-Estrada, Marta, Seijo-Martínez, Manuel, Ruiz Martínez, Javier, Valero, Caridad, Kurtis, Mónica, Fábregues-Boixar, Oriol de, González Ardura, Jessica, Prieto-Jurczynska, Cristina, Martínez-Martín, Pablo, Mir, Pablo, Kulisevsky, Jaime, Curemos el Párkinson, Martínez-Horta, Saúl, Bejr-Kasem, Helena, Horta-Barba, Andrea, Pascual-Sedano, Berta, Santos-García, Diego, Deus Fonticoba, T. de, Jesús Maestre, Silvia, Aguilar Barberá, Miquel, Planellas, Lluís, García Caldentey, Juan, Caballol, Nuria, Vives-Pastor, Bárbara, Hernández-Vara, Jorge, Cabo-Lopez, Iria, López-Manzanares, Lydia, González-Aramburu, Isabel, Ávila-Rivera, María A., Catalán, M. J., López-Díaz, Luis M., Puente, Víctor, García-Moreno, José Manuel, Borrué, Carmen, Solano Vila, Berta, Álvarez-Sauco, María, Vela, Lydia, Escalante, Sonia, Cubo, Esther, Carrillo Padilla, Francisco, Martínez-Castrillo, J. C., Sánchez Alonso, Pilar, Alonso Losada, María G., López-Ariztegui, Nuria, Gastón, Itziar, Blázquez-Estrada, Marta, Seijo-Martínez, Manuel, Ruiz Martínez, Javier, Valero, Caridad, Kurtis, Mónica, Fábregues-Boixar, Oriol de, González Ardura, Jessica, Prieto-Jurczynska, Cristina, Martínez-Martín, Pablo, Mir, Pablo, and Kulisevsky, Jaime

Abstract

[Background] Identifying modifiable risk factors for cognitive impairment in the early stages of Parkinson’s disease (PD) and estimating their impact on cognitive status may help prevent dementia (PDD) and the design of cognitive trials., [Methods] Using a standard approach for the assessment of global cognition in PD and controlling for the effects of age, education and disease duration, we explored the associations between cognitive status, comorbidities, metabolic variables and lifestyle variables in 533 PD participants from the COPPADIS study., [Results] Among the overall sample, 21% of participants were classified as PD-MCI (n = 114) and 4% as PDD (n = 26). The prevalence of hypertension, diabetes and dyslipidemia was significantly higher in cognitively impaired patients while no between-group differences were found for smoking, alcohol intake or use of supplementary vitamins. Better cognitive scores were significantly associated with regular physical exercise (p < 0.05) and cognitive stimulation (< 0.01). Cognitive performance was negatively associated with interleukin 2 (Il2) (p < 0.05), Il6 (p < 0.05), iron (p < 0.05), and homocysteine (p < 0.005) levels, and positively associated with vitamin B12 levels (p < 0.005)., [Conclusions] We extend previous findings regarding the positive and negative influence of various comorbidities and lifestyle factors on cognitive status in early PD patients, and reinforce the need to identify and treat potentially modifiable variables with the intention of exploring the possible improvement of the global cognitive status of patients with PD.

Published
2021

26. Staging Parkinson’s Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life

Author

Santos-García, Diego, Deus Fonticoba, T. de, Paz González, J. M., Cores Bartolomé, Carlos, Valdés Aymerich, Lorena, Muñoz Enríquez, J. G., Suárez, Ester, Jesús Maestre, Silvia, Aguilar Barberá, Miquel, Pastor, Pau, Planellas, Lluís, Cosgaya, Marina, García Caldentey, Juan, Caballol, Nuria, Legarda, Inés, Hernández-Vara, Jorge, Cabo-Lopez, Iria, López-Manzanares, Lydia, González-Aramburu, Isabel, Ávila-Rivera, María A., Catalán, M. J., Nogueira, Víctor, Puente, Víctor, García-Moreno, José Manuel, Borrué, Carmen, Solano Vila, Berta, Álvarez-Sauco, María, Vela, Lydia, Escalante, Sonia, Cubo, Esther, Carrillo Padilla, Francisco, Martínez-Castrillo, J. C., Sánchez Alonso, Pilar, Alonso, Gemma, López-Ariztegui, Nuria, Gastón, Itziar, Kulisevsky, Jaime, Blázquez-Estrada, Marta, Seijo-Martínez, Manuel, Ruiz Martínez, Javier, Valero, Caridad, Kurtis, Mónica, Fábregues-Boixar, Oriol de, Ardura, Jessica, Ordás, Carlos, López-Díaz, Luis M., Mir, Pablo, Martínez-Martín, Pablo, Santos-García, Diego, Deus Fonticoba, T. de, Paz González, J. M., Cores Bartolomé, Carlos, Valdés Aymerich, Lorena, Muñoz Enríquez, J. G., Suárez, Ester, Jesús Maestre, Silvia, Aguilar Barberá, Miquel, Pastor, Pau, Planellas, Lluís, Cosgaya, Marina, García Caldentey, Juan, Caballol, Nuria, Legarda, Inés, Hernández-Vara, Jorge, Cabo-Lopez, Iria, López-Manzanares, Lydia, González-Aramburu, Isabel, Ávila-Rivera, María A., Catalán, M. J., Nogueira, Víctor, Puente, Víctor, García-Moreno, José Manuel, Borrué, Carmen, Solano Vila, Berta, Álvarez-Sauco, María, Vela, Lydia, Escalante, Sonia, Cubo, Esther, Carrillo Padilla, Francisco, Martínez-Castrillo, J. C., Sánchez Alonso, Pilar, Alonso, Gemma, López-Ariztegui, Nuria, Gastón, Itziar, Kulisevsky, Jaime, Blázquez-Estrada, Marta, Seijo-Martínez, Manuel, Ruiz Martínez, Javier, Valero, Caridad, Kurtis, Mónica, Fábregues-Boixar, Oriol de, Ardura, Jessica, Ordás, Carlos, López-Díaz, Luis M., Mir, Pablo, and Martínez-Martín, Pablo

Abstract

[Introduction] In a degenerative disorder such as Parkinson’s disease (PD), it is important to establish clinical stages that allow to know the course of the disease. Our aim was to analyze whether a scale combining Hoehn and Yahr’s motor stage (H&Y) and the nonmotor symptoms burden (NMSB) (assessed by the nonmotor symptoms scale (NMSS)) provides information about the disability and the patient’s quality of life (QoL) with regard to a defined clinical stage., [Materials and Methods] Cross-sectional study in which 603 PD patients from the COPPADIS cohort were classified according to H&Y (1, stage I; 2, stage II; 3, stage III; 4, stage IV/V) and NMSB (A: NMSS = 0–20; B: NMSS = 21–40; C: NMSS = 41–70; D: NMSS ≥ 71) in 16 stages (HY.NMSB, from 1A to 4D). QoL was assessed with the PDQ-39SI, PQ-10, and EUROHIS-QOL8 and disability with the Schwab&England ADL (Activities of Daily Living) scale., [Results] A worse QoL and greater disability were observed at a higher stage of H&Y and NMSB (). Combining both (HY.NMSB), patients in stages 1C and 1D and 2C and 2D had significantly worse QoL and/or less autonomy for ADL than those in stages 2A and 2B and 3A and 3B, respectively (; e.g., PDQ-39SI in 1D [n = 15] vs 2A [n = 101]: 28.6 ± 17.1 vs 7.9 ± 5.8; )., [Conclusion] The HY.NMSB scale is simple and reflects the degree of patient involvement more accurately than the H&Y. Patients with a lower H&Y stage may be more affected if they have a greater NMS burden.

Published
2021

27. Lack of validation of variants associated with cervical dystonia risk: A GWAS replication study

Author

Gómez-Garre, Pilar, Huertas-Fernández, Ismael, Cáceres-Redondo, María Teresa, Alonso-Canovas, Araceli, Bernal-Bernal, Inmaculada, Blanco-Ollero, Alberto, Bonilla-Toribio, Marta, Burguera, Juan Andrés, Carballo, Manuel, Carrillo, Fatima, Catalán-Alonso, José M., Escamilla-Sevilla, Francisco, Espinosa-Rosso, Raul, Fernández-Moreno, María Carmen, García-Caldentey, Juan, García-Moreno, José Manuel, Giacometti-Silveira, Sandra, Gutiérrez-García, Javier, Jesús-Maestre, Silvia, López-Valdés, Eva, Martínez-Castrillo, Juan Carlos, Medialdea-Natera, María Pilar, Méndez-Lucena, Carolina, Mínguez-Castellanos, Adolfo, Moya, Miguel Angel, Ochoa-Sepulveda, Juan José, Ojea, Tomas, Rodríguez, Nuria, Rubio-Agusti, Ignacio, Sillero-Sánchez, Miriam, del Val, Javier, Vargas-González, Laura, and Mir, Pablo

Published
2014
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28. BDNF Val66Met polymorphism in primary adult-onset dystonia: A case-control study and meta-analysis

Author

Gómez-Garre, Pilar, Huertas-Fernández, Ismael, Cáceres-Redondo, María Teresa, Alonso-Canovas, Araceli, Bernal-Bernal, Inmaculada, Blanco-Ollero, Alberto, Bonilla-Toribio, Marta, Burguera, Juan Andrés, Carballo, Manuel, Carrillo, Fátima, Catalán-Alonso, María José, Escamilla-Sevilla, Francisco, Espinosa-Rosso, Raúl, Fernández-Moreno, María Carmen, García-Caldentey, Juan, García-Moreno, José Manuel, García-Ruiz, Pedro José, Giacometti-Silveira, Sandra, Gutiérrez-García, Javier, Jesús, Silvia, López-Valdés, Eva, Martínez-Castrillo, Juan Carlos, Martínez-Torres, Irene, Medialdea-Natera, María Pilar, Méndez-Lucena, Carolina, Mínguez-Castellanos, Adolfo, Moya, Miguel, Ochoa-Sepulveda, Juan José, Ojea, Tomás, Rodríguez, Nuria, Sillero-Sánchez, Miriam, Vargas-González, Laura, and Mir, Pablo

Published
2014
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29. La relación entre reformas legales y la asignación de la custodia compartida en España (2007-2017)

Author

Becerril Ruiz, Diego and García Moreno, José Manuel

Subjects
Divorcio, Marriage break, Divorce, Legislación familiar, Family legislation, Ruptura matrimonial, Custodia compartida, Shared custody
Abstract

La última década y media ha registrado transformaciones significativas en la legislación sobre rupturas matrimoniales. Una de las reformas con mayor impacto ha sido la posibilidad de la custodia compartida. A pesar de que estas regulaciones no han cesado de promulgarse, no existe un estudio como el presente, que relacione la legislación con la práctica de la custodia compartida en España. Este artículo utiliza como principal fuente de datos la Estadística de nulidades, separaciones y divorcios del INE, analizada a partir de sus microdatos. Se concluye que la existencia de una ley específica ha impulsado la custodia compartida, si bien esta práctica ha aumentado en aquellas comunidades autónomas donde ya era más frecuente con anterioridad. Ahora bien, otras variables intervienen en la asignación de custodias compartidas, como confirman los casos de Baleares o Comunidad Valenciana. Over the last decade and a half, the legislation on marital ruptures has experienced significant changes with the possibility of shared custody being one of the reforms with greater impact. Although these regulations have not ceased to be enacted, there is no study, such as this one, that relates legislation and practice of shared custody in Spain. This article uses the INE Statistics of nullities, separations and divorces, as the main data source analyzing it from its microdata. It is concluded that the existence of a specific law has triggered shared custodies; however, this practice has increased in those Autonomous Communities where it was previously more frequent. Yet, other variables also intervene in the assignment of shared custodies, as confirmed by the cases of the Balearic Islands or the Valencian Community.

Published
2020

30. La relación entre reformas legales y la asignación de la custodia compartida en España (2007-2017)

Author

Jiménez Cabello, José Manuel, Becerril Ruiz, Diego, García Moreno, José Manuel, Jiménez Cabello, José Manuel, Becerril Ruiz, Diego, and García Moreno, José Manuel

Abstract

Over the last decade and a half, the legislation on marital ruptures has experienced significant changes with the possibility of shared custody being one of the reforms with greater impact. Although these regulations have not ceased to be enacted, there is no study, such as this one, that relates legislation and practice of shared custody in Spain. This article uses the INE Statistics of nullities, separations and divorces, as the main data source analyzing it from its microdata. It is concluded that the existence of a specific law has triggered shared custodies; however, this practice has increased in those Autonomous Communities where it was previously more frequent. Yet, other variables also intervene in the assignment of shared custodies, as confirmed by the cases of the Balearic Islands or the Valencian Community., La última década y media ha registrado transformaciones significativas en la legislación sobre rupturas matrimoniales. Una de las reformas con mayor impacto ha sido la posibilidad de la custodia compartida. A pesar de que estas regulaciones no han cesado de promulgarse, no existe un estudio como el presente, que relacione la legislación con la práctica de la custodia compartida en España. Este artículo utiliza como principal fuente de datos la Estadística de nulidades, separaciones y divorcios del INE, analizada a partir de sus microdatos. Se concluye que la existencia de una ley específica ha impulsado la custodia compartida, si bien esta práctica ha aumentado en aquellas comunidades autónomas donde ya era más frecuente con anterioridad. Ahora bien, otras variables intervienen en la asignación de custodias compartidas, como confirman los casos de Baleares o Comunidad Valenciana.

Published
2020

31. Novel CACNA1A variant may cause cervical dystonia and cerebellar ataxia syndrome

Author

Fuerte, Alejandro, Pérez Noguera, R., Dotor, Julio, Royo Boronat, I., Álvarez de Andrés, S., García-Moreno, José Manuel, Fuerte, Alejandro, Pérez Noguera, R., Dotor, Julio, Royo Boronat, I., Álvarez de Andrés, S., and García-Moreno, José Manuel

Abstract

Pure spinocerebellar ataxias (SCA) are rare in isolation; they commonly appear in association with other neurological disorders. Very rarely, cerebellar ataxia (typically slowly progressive) is associated with isolated cervical dystonia. This combination of disorders gives rise to great diagnostic uncertainty. The literature includes reports of several recent cases of this association, which rule out the mutations causing common SCAs and do not identify a definite cause. It has been suggested that this combination of disorders may be a distinct clinical entity. We present the case of a patient with a syndrome of cervical dystonia and cerebellar ataxia similar to those reported in the literature, in which we detected an as yet undescribed pathogenic mutation that may be the cause of the syndrome, at least in our patient.

Published
2020

33. Mutational spectrum of GNAL , THAP1 and TOR1A genes in isolated dystonia: study in a population from Spain and systematic literature review

Author

Gómez‐Garre, Pilar, primary, Jesús, Silvia, additional, Periñán, María Teresa, additional, Adarmes, Astrid, additional, Alonso‐Canovas, Araceli, additional, Blanco‐Ollero, Alberto, additional, Buiza‐Rueda, Dolores, additional, Carrillo, Fátima, additional, Catalán‐Alonso, María José, additional, Val, Javier, additional, Escamilla‐Sevilla, Francisco, additional, Espinosa‐Rosso, Raúl, additional, Fernández‐Moreno, María Carmen, additional, García‐Moreno, José Manuel, additional, García‐Ruiz, Pedro José, additional, Giacometti‐Silveira, Sandra, additional, Gutiérrez‐García, Javier, additional, López‐Valdés, Eva, additional, Macías‐García, Daniel, additional, Martínez‐Castrillo, Juan Carlos, additional, Martínez‐Torres, Irene, additional, Medialdea‐Natera, María Pilar, additional, Mínguez‐Castellanos, Adolfo, additional, Moya, Miguel Ángel, additional, Ochoa‐Sepulveda, Juan José, additional, Ojea, Tomás, additional, Rodríguez, Nuria, additional, Sillero‐Sánchez, Miriam, additional, Tejera‐Parrado, Cristina, additional, and Mir, Pablo, additional

Published
2020
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34. DISOLUCIÓN MATRIMONIAL DE PAREJAS DEL MISMO SEXO: ¿A quién se atribuye la custodia de los hijos?

Author

Jimenez Cabello, José Manuel, Becerril Ruíz, Diego, and García Moreno, José Manuel

Subjects
SOCIAL factors, SAME-sex marriage, CUSTODY of children, CHILDREN of divorced parents, SOCIAL influence, MULTIVARIATE analysis, MINORS, DIVORCE
Abstract

Copyright of Sociologia, Problemas e Práticas is the property of Centro de Investigacao e Estudos de Sociologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022
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35. Daño cardiaco frente a hepático por consumo de bebidas energizantes en ratas cepa Holtzman

Author

García-Villacorta, Josue Salomón, Eustaquio-Cosme, Josué Paul, Esparza-Varas, Analis Lisseth, Gonzalez-Angulo, Leydi Thays, Flores-Quiñones, Gino Fabriccio, Floriano-Leiva, Marlen Adrián Alfredo, Gallegos-Ortiz, Sonia Julissa, De La Cruz-Araujo, Jonathan Waldir, García-Moreno, José Manuel, Espinoza-Cueva, Francis Emilio, Díaz-Cubas, Yuliset, Gonzalez-Bazán, Ángel Alejandro, De La Cruz-Vargas, Kevin, Enríquez-Flores, Jairo, Vergara-De-La-Rosa, Esteban Iván, Plasencia-Álvarez, Jorge, and Llerena-Vásquez, Cesar Francisco

Abstract

RESUMENObjetivo: El consumo de bebidas energéticas (BE) está aumentando principalmente en jóvenes, debido a que promete mejorar el estado de alerta, el rendimiento físico y cognitivo y evita la fatiga. En nuestro país, una BE tiene alta concentración de cafeína y azúcar por botella, y es altamente comercializada y barata. Sin embargo, las BE tienen efectos adversos como complicaciones cardiovasculares, neurales y gastrointestinales. Los estudios indican un mayor daño en hígado y corazón, señalados por altos niveles séricos de GOT y daño tisular. El objetivo de nuestro estudio es determinar si el corazón o hígado, presenta más daño por consumo de BE en ratas Holtzman. Métodos: Se clasificaron 32 ratas Holtzman macho aleatoriamente en dos grupos con tratamientos diferentes por administración oral. El Grupo 1 (Control) recibió agua potable y el Grupo 2 (Experimental) recibió una bebida energética de 5,49 ml / 260 g; ambos grupos durante 30 días. Se proporcionó aclimatación previa y alimento. Durante el período experimental, hubo cuatro extracciones de sangre para análisis de GOT sérico. Se sacrificaron por exanguinación bajo anestesia obteniendo muestras de corazón e hígado. Resultados: Se encontró aumento de la concentración sérica de GOT en el grupo experimental comparado con el control. El análisis histológico que evaluó congestión vascular, necrosis y edema en ambos tejidos, reveló que el corazón tenía mayor daño que el hígado. Conclusión: El tejido cardiaco presenta mayor daño que el tejido hepático por consumo de BE en ratas Holtzman macho, manifestados por incremento de GOT y alteraciones histopatológicas.Palabras clave: Bebidas energéticas, transaminasas glutámicas oxaloacéticas (GOT), daño cardiaco, daño hepático. DOI: http://dx.doi.org/10.17268/rmt.2019.v14i03.05

Published
2019

36. ¿Siguen vigentes los modelos teóricos clásicos de la inserción laboral juvenil?

Author

García Moreno, José Manuel and Feliciano Pérez, Laura

Subjects
Movilidad social, Mercado de trabajo, Juventud, Empleo, Formación
Abstract

La vigencia de cualquier teoría depende de que sus hipótesis resistan al paso del tiempo y a la evidencia empírica más allá de la época en que fueron planteadas. En este trabajo se realiza el esfuerzo de contrastar las teorías clásicas de la inserción laboral, tratando de validarlas nuevamente, pero con datos más recientes, para el contexto español y centrando la atención en la población joven de nuestro país entre 2006 y 2014 (todo el periodo que va desde los albores de la crisis económica -antes de 2007- hasta 2014, momento donde la economía española parecía mejorar). Con datos de diferentes fuentes (teóricas y estadísticas) se ha tratado de confirmar la actualidad o no de dichos planteamientos teóricos clásicos concluyendo que, con matices propios del contexto temporal elegido, muchas de las hipótesis de esas teorías siguen siendo útiles aún para el análisis, interpretación y explicación de la inserción laboral de los jóvenes en España., The validity of any theory depends on its hypothesis resisting the passage of time and empirical evidence beyond the time they were raised. In this paper an effort is made to contrast the classical theories of labor insertion, trying to validate them again, but with more recent data, for the Spanish context and focusing attention on the young population of our country between 2006 and 2014 (the entire period that goes from the dawn of the economic crisis - before 2007 - until 2014, when the Spanish economy seemed to improve). With data from different sources (theoretical and statistical) we have tried to confirm or not the current approach of such classical theoretical approaches, concluding that, with nuances of the chosen temporal context, many of the hypotheses of these theories are still useful for the analysis, the interpretation and explanation of the labor insertion of young people in Spain.

Published
2019

37. Identification of symbol digit modality test score extremes in Huntington's disease

Author

European Commission, Braisch, Ulrike, Muche, Rainer, Rothenbacher, Dietrich, Landwehrmeyer, Georg Bernhard, Long, Jeffrey D., Orth, Michael, Carrillo, Fátima, Cáceres-Redondo, María T., Mir, Pablo, Vargas-González, Laura, García-Moreno, José Manuel, European Commission, Braisch, Ulrike, Muche, Rainer, Rothenbacher, Dietrich, Landwehrmeyer, Georg Bernhard, Long, Jeffrey D., Orth, Michael, Carrillo, Fátima, Cáceres-Redondo, María T., Mir, Pablo, Vargas-González, Laura, and García-Moreno, José Manuel

Abstract

Studying individuals with extreme phenotypes could facilitate the understanding of disease modification by genetic or environmental factors. Our aim was to identify Huntington's disease (HD) patients with extreme symbol digit modality test (SDMT) scores. We first examined in HD the contribution of cognitive measures of the Unified Huntington's Disease Rating Scale (UHDRS) in predicting clinical endpoints. The language-independent SDMT was used to identify patients performing very well or very poorly relative to their CAG and age cohort. We used data from REGISTRY and COHORT observational study participants (5,603 HD participants with CAG repeats above 39 with 13,868 visits) and of 1,006 healthy volunteers (with 2,241 visits), included to identify natural aging and education effects on cognitive measures. Separate Cox proportional hazards models with CAG, age at study entry, education, sex, UHDRS total motor score and cognitive (SDMT, verbal fluency, Stroop tests) scores as covariates were used to predict clinical endpoints. Quantile regression for longitudinal language-independent SDMT data was used for boundary (2.5% and 97.5% quantiles) estimation and extreme score analyses stratified by age, education, and CAG repeat length. Ten percent of HD participants had an extreme SDMT phenotype for at least one visit. In contrast, only about 3% of participants were consistent SDMT extremes at two or more visits. The thresholds for the one-visit and two-visit extremes can be used to classify existing and new individuals. The identification of these phenotype extremes can be useful in the search for disease modifiers.

Published
2019

40. Mutational spectrum of GNAL, THAP1 and TOR1A genes in isolated dystonia: study in a population from Spain and systematic literature review.

Author

Gómez‐Garre, Pilar, Jesús, Silvia, Periñán, María Teresa, Adarmes, Astrid, Alonso‐Canovas, Araceli, Blanco‐Ollero, Alberto, Buiza‐Rueda, Dolores, Carrillo, Fátima, Catalán‐Alonso, María José, Val, Javier, Escamilla‐Sevilla, Francisco, Espinosa‐Rosso, Raúl, Fernández‐Moreno, María Carmen, García‐Moreno, José Manuel, García‐Ruiz, Pedro José, Giacometti‐Silveira, Sandra, Gutiérrez‐García, Javier, López‐Valdés, Eva, Macías‐García, Daniel, and Martínez‐Castrillo, Juan Carlos

Subjects
GENES, DYSTONIA, DNA analysis, AGE of onset
Abstract

Objective: We aimed to investigate the prevalence of TOR1A, GNAL and THAP1 variants as the cause of dystonia in a cohort of Spanish patients with isolated dystonia and in the literature. Methods: A population of 2028 subjects (including 1053 patients with different subtypes of isolated dystonia and 975 healthy controls) from southern and central Spain was included. The genes TOR1A, THAP1 and GNAL were screened using a combination of high‐resolution melting analysis and direct DNA resequencing. In addition, an extensive literature search to identify original articles (published before 10 August 2020) reporting mutations in TOR1A, THAP1 or GNAL associated to dystonia was performed. Results: Pathogenic or likely pathogenic variants in TOR1A, THAP1 and GNAL were identified in 0.48%, 0.57% and 0.29% of our patients, respectively. Five patients carried the variation p.Glu303del in TOR1A. A very rare variant in GNAL (p.Ser238Asn) was found as a putative risk factor for dystonia. In the literature, variations in TOR1A, THAP1 and GNAL accounted for about 6%, 1.8% and 1.1% of published dystonia patients, respectively. Conclusions: There is a different genetic contribution to dystonia of these three genes in our patients (about 1.3% of patients) and in the literature (about 3.6% of patients), probably due the high proportion of adult‐onset cases in our cohort. As regards age at onset, site of dystonia onset, and final distribution, in our population there is a clear differentiation between DYT‐TOR1A and DYT‐GNAL, with DYT‐THAP1 likely to be an intermediate phenotype. [ABSTRACT FROM AUTHOR]

Published
2021
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41. Can suitable candidates for levodopa/carbidopa intestinal gel therapy be identified using current evidence?

Author

Catalán Alonso, Maria José, Antonini, Angelo, Calopa Garriga, Matilde, Bajenaru, Ovidiu, Fàbregues, Oriol de, Mínguez Castellanos, Adolfo, Odin, Per, García Moreno, José Manuel, Pedersen, Stephen W., Pirtosek, Zvezdan, Kulisevsky Bojarski, Jaume, Hospital Clínico San Carlos, IRCCS Ospedale San Camillo, Hospital Universitari de Bellvitge, Carol Davila University of Medicine and Pharmacy, Vall d'Hebron Barcelona Hospital Campus, Complejo Hospitalario Universitario de Granada, Lund University, Hospital Universitario Virgen Macarena, University of Copenhagen, University Medical Centre Ljubljana, and Universitat Oberta de Catalunya

Subjects
duodopa, enfermedad de Parkinson, Parkinson's disease, infusió intraieiunal de levodopa/carbidopa, Intrajejunal infusion of levodopa/carbidopa, qualitat de vida, símptomes motors, motor symptoms, Parkinson, Enfermedad de, non-motor symptoms, infusión intrayeyunal de levodopa/carbidopa, quality of life, síntomas motores, símptomes no motors, calidad de vida, enfermetat de Parkinson, síntomas no motores, gel intestinal, Parkinson, Malaltia de, intestinal gel
Abstract

Advanced Parkinson's disease (APD) is characterized by increased functional disability, caused by motor complications, the presence of axial symptoms, and emergent disease- and drug-related non-motor symptoms. One of the advanced therapies available is intrajejunal infusion of levodopa/carbidopa intestinal gel (LCIG); however, patient selection for this treatment is sometimes difficult, particularly because of overlapping indications with other alternatives. In recent years, strong evidence has supported the use of LCIG in treating motor fluctuations associated with APD, and several clinical studies provide emerging evidence for additional benefits of LCIG treatment in certain patients. This article provides an overview of the published literature on the benefits, limitations, and drawbacks of LCIG in relation to PD symptoms, the psychosocial impact of the disease, and the quality of life of patients, with the aim of determining candidates for whom treatment with LCIG would be beneficial. According to current evidence, patients with APD (defined as inability to achieve optimal control of the disease with conventional oral treatment), a relatively well-preserved cognitive-behavioral status, and good family/caregiver would count as suitable candidates for LCIG treatment. Contraindications in the opinion of the authors are severe dementia and active psychosis.

Published
2017

43. Can suitable candidates for levodopa/carbidopa intestinal gel therapy be identified using current evidence?

Author

Catalán, Maria José, primary, Antonini, Angelo, additional, Calopa, Matilde, additional, Băjenaru, Ovidiu, additional, de Fábregues, Oriol, additional, Mínguez-Castellanos, Adolfo, additional, Odin, Per, additional, García-Moreno, José Manuel, additional, Pedersen, Stephen W., additional, Pirtošek, Zvezdan, additional, and Kulisevsky, Jaime, additional

Published
2017
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46. El trabajador social del siglo XXI

Author

Herrera Gómez, Manuel, Lima, Ana, Martínez, Mª Ángeles, Ayuso, Luis, García Moreno, José Manuel, and Ahedo, Josu

Subjects
UNIR claves, servicios sociales, libros, UNIR editorial, ciencias sociales, bienestar social, sociedad
Abstract

Si estás interesado en el libro consíguelo en www.amazon.es ¿Cuáles van a ser las funciones fundamentales del trabajador social en el siglo XXI? ¿Cómo ha influido el uso de Internet en los servicios sociales? ¿Qué rol deben desempeñar las asociaciones familiares? ¿Pueden surgir nuevos yacimientos de empleo en torno al denominado «cuarto sector»? En "El trabajador social del siglo XXI" los profesores Ana Lima, Manuel Herrera, Mª Ángeles Martínez, Luis Ayuso y José Manuel García Moreno ofrecen una respuesta detallada y completa sobre todas estas cuestiones. La actual situación de crisis ha afectado considerablemente a los servicios sociales y ha hecho tambalear el sistema de bienestar monopolizado por el Estado, produciendo al mismo tiempo un aumento del número de personas necesitadas y excluidas de la sociedad. En consecuencia, urge un replanteamiento y redefinición de la profesión de los trabajadores sociales, así como un plan de formación adecuado a las nuevas circunstancias. Un libro imprescindible para todos aquellos que quieran entender el presente y el futuro del trabajo social en España.

Published
2014

50. Training for employment: an analysis of the business sector context in Spain

Author

Martínez Martín, Rafael, García Moreno, José Manuel, Izcara Palacios, Simón Pedro, Martínez Martín, Rafael, García Moreno, José Manuel, and Izcara Palacios, Simón Pedro

Abstract

La formación profesional aparece como la principal política activa de empleo. Su importancia radica en la necesidad de que los empleadores cuenten con capital humano adecuado a las nuevas necesidades productivas, capaz de adaptarse a los cambios tecnológicos y de incrementar los niveles de competitividad. La formación juega un papel fundamental a la hora de conseguir niveles elevados de inserción profesional, y como instrumento que incide de forma notable en la profesionalización y especialización de los trabajadores. El papel de la formación en el mundo del trabajo está bien definido, desde un punto de vista teórico, pero no se debe obviar a uno de los principales actores en este proceso, como son los empresarios. Por ello, el principal objetivo de este artículo es el análisis de la formación continua en las empresas españolas., Vocational training appears as the main active employment policy. Its importance is in the necessity of employers to count on an adequate human capital to deal with the new demands of the production field, capable to adapt to technological changes and increase the levels of competitiveness. Training has an important role when obtaining high levels of professional insertion and as an instrument which has a major influence on the professionalization and specialization of the workers. The training role in the labour world is well defined from a theoretical point of view, but it must not be forgotten one of the main actors on this process, such as the entrepreneurs. Thus, the main objective of this article lays in the analysis of vocational training within the Spanish companies.

Published
2015

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